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Penny kris-etherton

Anuja Dokras, Martin Playford, Penny M Kris-Etherton, Allen R Kunselman, Christy M Stetter, Nancy I Williams, Carol L Gnatuk, Stephanie J Estes, David B Sarwer, Kelly C Allison, Christos Coutifaris, Nehal Mehta, Richard S Legro
OBJECTIVE: To study the effects of oral contraceptive pills (OCP), the first line treatment for PCOS, on HDL-C function (reverse cholesterol efflux capacity) and lipoprotein particles measured by NMR spectroscopy. DESIGN: Secondary analysis of a randomized controlled trial (OWL-PCOS) of OCP or Lifestyle (intensive lifestyle modification) or Combined (OCP+Lifestyle) treatment for 16 weeks. PATIENTS: 87 overweight/obese women with PCOS at two academic centers...
February 15, 2017: Clinical Endocrinology
Marie-Pierre St-Onge, Jamy Ard, Monica L Baskin, Stephanie E Chiuve, Heather M Johnson, Penny Kris-Etherton, Krista Varady
Eating patterns are increasingly varied. Typical breakfast, lunch, and dinner meals are difficult to distinguish because skipping meals and snacking have become more prevalent. Such eating styles can have various effects on cardiometabolic health markers, namely obesity, lipid profile, insulin resistance, and blood pressure. In this statement, we review the cardiometabolic health effects of specific eating patterns: skipping breakfast, intermittent fasting, meal frequency (number of daily eating occasions), and timing of eating occasions...
January 30, 2017: Circulation
Zhijun Wu, Zhe Huang, Wei Jin, Eric B Rimm, Alice H Lichtenstein, Penny M Kris-Etherton, Shouling Wu, Xiang Gao
BACKGROUND: Most previous studies regarding chronic inflammation and risk of myocardial infarction (MI) have lacked repeated measures of high-sensitivity C-reactive protein (hs-CRP) and/or white blood cell (WBC) count over time. We examined whether cumulative average and longitudinal changes in these biomarkers were associated with subsequent MI risk. METHODS: In this prospective, community-based study, we included 82544 Chinese participants [66796 men and 15748 women; mean (SD) age 55...
December 28, 2016: Clinical Chemistry
Chesney K Richter, Ann C Skulas-Ray, Trent L Gaugler, Joshua D Lambert, David N Proctor, Penny M Kris-Etherton
BACKGROUND: Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects. OBJECTIVE: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (∼1 lb...
February 2017: American Journal of Clinical Nutrition
Xiaoran Liu, Penny M Kris-Etherton, Sheila G West, Benoît Lamarche, David J A Jenkins, Jennifer A Fleming, Cindy E McCrea, Shuaihua Pu, Patrick Couture, Philip W Connelly, Peter J H Jones
OBJECTIVE: To determine the effect of diets low in saturated fatty acids and high in monounsaturated fatty acids (MUFA) or polyunsaturated fatty acids on body composition in participants at risk for metabolic syndrome (MetS). METHODS: This study was a randomized, crossover, controlled feeding study. Participants (n = 101, ages 49.5 ± 1.2, BMI 29.4 ± 0.4 kg/m(2) ) were randomized to five isocaloric diets containing treatment oils: Canola, CanolaOleic, CanolaDHA, Corn/Safflower, and Flax/Safflower...
November 2016: Obesity
Linda Van Horn, Jo Ann S Carson, Lawrence J Appel, Lora E Burke, Christina Economos, Wahida Karmally, Kristie Lancaster, Alice H Lichtenstein, Rachel K Johnson, Randal J Thomas, Miriam Vos, Judith Wylie-Rosett, Penny Kris-Etherton
In 2013, the American Heart Association and American College of Cardiology published the "Guideline on Lifestyle Management to Reduce Cardiovascular Risk," which was based on a systematic review originally initiated by the National Heart, Lung, and Blood Institute. The guideline supports the American Heart Association's 2020 Strategic Impact Goals for cardiovascular health promotion and disease reduction by providing more specific details for adopting evidence-based diet and lifestyle behaviors to achieve those goals...
November 29, 2016: Circulation
Kate J Bowen, William S Harris, Penny M Kris-Etherton
Early secondary prevention trials of fish and omega-3 polyunsaturated fatty acid (PUFA) capsules reported beneficial effects on cardiovascular disease (CVD) outcomes, including all-cause mortality and sudden cardiac death. These clinical findings, as well as observational and experimental data, demonstrated that omega-3 PUFAs reduced the risk of coronary outcomes and overall mortality and were the basis for recommendations made in the early 2000s to increase omega-3 PUFA intake. In the last 6 years, however, results from both primary and secondary prevention trials have generally failed to show a beneficial effect of omega-3 PUFA supplementation, bringing current recommendations into question...
November 2016: Current Treatment Options in Cardiovascular Medicine
John Cawley, Chad Meyerhoefer, Leah G Gillingham, Penny Kris-Etherton, Peter J H Jones
AIMS: Diets high in saturated fat are associated with elevated risk of heart disease. This study estimates the savings in direct (medical care) costs and indirect (job absenteeism) costs in the US from reductions in heart disease associated with substituting monounsaturated fats (MUFA) for saturated fats. MATERIALS AND METHODS: A four-part model of the medical care cost savings from avoided heart disease was estimated using data on 247,700 adults from the 2000-2010 Medical Expenditure Panel Survey (MEPS)...
February 2017: Journal of Medical Economics
Marie-France Hivert, Ross Arena, Daniel E Forman, Penny M Kris-Etherton, Patrick E McBride, Russell R Pate, Bonnie Spring, Jennifer Trilk, Linda V Van Horn, William E Kraus
No abstract text is available yet for this article.
October 11, 2016: Circulation
Anuja Dokras, David B Sarwer, Kelly C Allison, Lauren Milman, Penny M Kris-Etherton, Allen R Kunselman, Christy M Stetter, Nancy I Williams, Carol L Gnatuk, Stephanie J Estes, Jennifer Fleming, Christos Coutifaris, Richard S Legro
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with reduced health-related quality of life (HRQOL) and increased prevalence of depressive and anxiety disorders. The impact of PCOS-specific treatments on these co-morbidities is unclear. OBJECTIVE: To assess the impact of weight loss and decreasing hyperandrogenism on HRQOL and mood and anxiety disorders in women with PCOS. DESIGN/SETTING/PARTICIPANTS: A secondary analysis of a randomized controlled trial (OWL-PCOS) of preconception treatment conducted at two academic centers in women (age, 18-40 years; body mass index, 27-42 kg/m(2)) with PCOS defined by Rotterdam criteria...
August 2016: Journal of Clinical Endocrinology and Metabolism
Richard S Legro, William C Dodson, Allen R Kunselman, Christy M Stetter, Penny M Kris-Etherton, Nancy I Williams, Carol L Gnatuk, Stephanie J Estes, Kelly C Allison, David B Sarwer, Michael P Diamond, William D Schlaff, Peter R Casson, Gregory M Christman, Kurt T Barnhart, G Wright Bates, Rebecca Usadi, Scott Lucidi, Valerie Baker, Heping Zhang, Esther Eisenberg, Christos Coutifaris, Anuja Dokras
CONTEXT: In overweight/obese women with polycystic ovary syndrome (PCOS), the relative benefit of delaying infertility treatment to lose weight vs seeking immediate treatment is unknown. OBJECTIVE: We compared the results of two, multicenter, concurrent clinical trials treating infertility in women with PCOS. DESIGN, SETTING, AND PARTICIPANTS: This was a secondary analysis of two randomized trials conducted at academic health centers studying women 18-40 years of age who were overweight/obese and infertile with PCOS...
July 2016: Journal of Clinical Endocrinology and Metabolism
Jane F Ferguson, Hooman Allayee, Robert E Gerszten, Folami Ideraabdullah, Penny M Kris-Etherton, José M Ordovás, Eric B Rimm, Thomas J Wang, Brian J Bennett
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome...
June 2016: Circulation. Cardiovascular Genetics
Darwin R Labarthe, Larry B Goldstein, Elliott M Antman, Donna K Arnett, Gregg C Fonarow, Mark J Alberts, Laura L Hayman, Amit Khera, James F Sallis, Stephen R Daniels, Ralph L Sacco, Suhui Li, Leighton Ku, Paula M Lantz, Jennifer G Robinson, Mark A Creager, Linda Van Horn, Penny Kris-Etherton, Aruni Bhatnagar, Laurie P Whitsel
BACKGROUND: American Heart Association (AHA) public policy advocacy strategies are based on its Strategic Impact Goals. The writing group appraised the evidence behind AHA's policies to determine how well they address the association's 2020 cardiovascular health (CVH) metrics and cardiovascular disease (CVD) management indicators and identified research needed to fill gaps in policy and support further policy development. METHODS AND RESULTS: The AHA policy research department first identified current AHA policies specific to each CVH metric and CVD management indicator and the evidence underlying each policy...
May 3, 2016: Circulation
Jennifer A Fleming, Penny M Kris-Etherton
The 2013 AHA/ACC Clinical Guideline for the Management of Overweight and Obesity recommends a reduced energy diet for weight loss regardless of the macronutrient content. However, diet composition may affect the maintenance of weight loss. In general, a healthful dietary pattern with reduced portion sizes, low energy dense foods, and physical activity are successful for many. Certain populations, such as those with insulin resistance, may find reductions in carbohydrate and higher levels of unsaturated fats to be more effective and promote greater adherence...
June 2016: Current Obesity Reports
Shana J Kim, Russell J de Souza, Vivian L Choo, Vanessa Ha, Adrian I Cozma, Laura Chiavaroli, Arash Mirrahimi, Sonia Blanco Mejia, Marco Di Buono, Adam M Bernstein, Lawrence A Leiter, Penny M Kris-Etherton, Vladimir Vuksan, Joseph Beyene, Cyril Wc Kendall, David Ja Jenkins, John L Sievenpiper
BACKGROUND: Obesity is a risk factor for developing several diseases, and although dietary pulses (nonoil seeds of legumes such as beans, lentils, chickpeas, and dry peas) are well positioned to aid in weight control, the effects of dietary pulses on weight loss are unclear. OBJECTIVE: We summarized and quantified the effects of dietary pulse consumption on body weight, waist circumference, and body fat by conducting a systematic review and meta-analysis of randomized controlled trials...
May 2016: American Journal of Clinical Nutrition
Arianna Carughi, Mary Jo Feeney, Penny Kris-Etherton, Victor Fulgoni, Cyril W C Kendall, Mònica Bulló, Densie Webb
Certain dietary patterns, in which fruits and nuts are featured prominently, reduce risk of diabetes and cardiovascular disease. However, estimated fruit consumption historically in the U.S. has been lower than recommendations. Dried fruit intake is even lower with only about 6.9 % of the adult population reporting any consumption. The 2015 Dietary Guidelines Advisory Committee identified a gap between recommended fruit and vegetable intakes and the amount the population consumes. Even fewer Americans consume tree nuts, which are a nutrient-dense food, rich in bioactive compounds and healthy fatty acids...
March 5, 2016: Nutrition Journal
Huicui Meng, Yujin Lee, Zhaoyong Ba, Jiayu Peng, Junli Lin, Alexander S Boyer, Jennifer A Fleming, Emily J Furumoto, Robert F Roberts, Penny M Kris-Etherton, Connie J Rogers
SCOPE: Probiotics can modulate immunity and reduce upper respiratory tract infections (URTI) in humans; however few studies have examined both outcomes in the same trial. The goal of the current study was to investigate the effect of Bifidobacterium animalis subsp. lactis BB-12, on natural killer (NK) and T-cell function in conjunction with self-reported cold/flu outcomes in healthy adults. METHODS AND RESULTS: In a randomized, partially blinded, four-period crossover study, healthy adults (n = 30) were recruited, and received four treatments for 4 weeks in a random order: (i) yogurt smoothies alone (YS); smoothies with BB-12 added (ii) before (PRE) or (iii) after (POST) yogurt fermentation, or (iv) BB-12 capsule (CAP)...
May 2016: Molecular Nutrition & Food Research
Shuaihua Pu, Peter Eck, David J A Jenkins, Philip W Connelly, Benoît Lamarche, Penny M Kris-Etherton, Sheila G West, Xiaoran Liu, Peter J H Jones
Fatty acid ethanolamides (FAE), a group of lipid mediators derived from long-chain fatty acids (FA), mediate biological activities including activation of cannabinoid receptors, stimulation of fat oxidation and regulation of satiety. However, how circulating FAE levels are influenced by FA intake in humans remains unclear. The objective of the present study was to investigate the response of six major circulating FAE to various dietary oil treatments in a five-period, cross-over, randomised, double-blind, clinical study in volunteers with abdominal obesity...
March 28, 2016: British Journal of Nutrition
Terry A Jacobson, Kevin C Maki, Carl E Orringer, Peter H Jones, Penny Kris-Etherton, Geeta Sikand, Ralph La Forge, Stephen R Daniels, Don P Wilson, Pamela B Morris, Robert A Wild, Scott M Grundy, Martha Daviglus, Keith C Ferdinand, Krishnaswami Vijayaraghavan, Prakash C Deedwania, Judith A Aberg, Katherine P Liao, James M McKenney, Joyce L Ross, Lynne T Braun, Matthew K Ito, Harold E Bays, W Virgil Brown, James A Underberg
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non-high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk for atherosclerotic cardiovascular disease. This document represents a continuation of the National Lipid Association recommendations developed by a diverse panel of experts who examined the evidence base and provided recommendations regarding the following topics: (1) lifestyle therapies; (2) groups with special considerations, including children and adolescents, women, older patients, certain ethnic and racial groups, patients infected with human immunodeficiency virus, patients with rheumatoid arthritis, and patients with residual risk despite statin and lifestyle therapies; and (3) strategies to improve patient outcomes by increasing adherence and using team-based collaborative care...
November 2015: Journal of Clinical Lipidology
Huicui Meng, Zhaoyong Ba, Yujin Lee, Jiayu Peng, Junli Lin, Jennifer A Fleming, Emily J Furumoto, Robert F Roberts, Penny M Kris-Etherton, Connie J Rogers
PURPOSE: Probiotic bacteria modulate immune parameters and inflammatory outcomes. Emerging evidence demonstrates that the matrix used to deliver probiotics may influence the efficacy of probiotic interventions in vivo. The aims of the current study were to evaluate (1) the effect of one species, Bifidobacterium animalis subsp. lactis BB-12 at a dose of log10 ± 0.5 CFUs/day on immune responses in a randomized, partially blinded, 4-period crossover, free-living study, and (2) whether the immune response to BB-12 differed depending on the delivery matrix...
November 30, 2015: European Journal of Nutrition
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