keyword
MENU ▼
Read by QxMD icon Read
search

CD71

keyword
https://www.readbyqxmd.com/read/29769438/cytometry-tof-identifies-alveolar-macrophage-subtypes-in-acute-respiratory-distress-syndrome
#1
Eric D Morrell, Alice Wiedeman, S Alice Long, Sina A Gharib, T Eoin West, Shawn J Skerrett, Mark M Wurfel, Carmen Mikacenic
Studies in human peripheral blood monocyte-derived macrophages in vitro have shown clear evidence that multiple macrophage polarization states exist. The extent to which different alveolar macrophage (AM) polarization states exist in homeostasis or in the setting of severe injury such as acute respiratory distress syndrome (ARDS) is largely unknown. We applied single-cell cytometry TOF (CyTOF) to simultaneously measure 36 cell-surface markers on CD45+ cells present in bronchoalveolar lavage from healthy volunteers, as well as mechanically ventilated subjects with and without ARDS...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29735482/cd71-erythroid-suppressor-cells-promote-fetomaternal-tolerance-through-arginase-2-and-pdl-1
#2
Cole Delyea, Najmeh Bozorgmehr, Petya Koleva, Garett Dunsmore, Shima Shahbaz, Vivian Huang, Shokrollah Elahi
Survival of the allogeneic pregnancy depends on the maintenance of immune tolerance to paternal alloantigens at the fetomaternal interface. Multiple localized mechanisms contribute to the fetal evasion from the mother's immune rejection as the fetus is exposed to a wide range of stimulatory substances such as maternal alloantigens, microbes and amniotic fluids. In this article, we demonstrate that CD71+ erythroid cells are expanded at the fetomaternal interface and in the periphery during pregnancy in both humans and mice...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29720425/canonical-tgf-%C3%AE-signaling-pathway-represses-human-nk-cell-metabolism
#3
Vanessa Zaiatz-Bittencourt, David K Finlay, Clair M Gardiner
Cytokines stimulate rapid metabolic changes in human NK cells, including increases in both glycolysis and oxidative phosphorylation pathways. However, how these are subsequently regulated is not known. In this study, we demonstrate that TGF-β can inhibit many of these metabolic changes, including oxidative phosphorylation, glycolytic capacity, and respiratory capacity. TGF-β also inhibited cytokine-induced expression of the transferrin nutrient receptor CD71. In contrast to a recent report on murine NK cells, TGF-β-mediated suppression of these metabolic responses did not involve the inhibition of the metabolic regulator mTORC1...
May 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29701016/functional-integrity-and-gene-expression-profiles-of-human-cord-blood-derived-hematopoietic-stem-and-progenitor-cells-generated-in-vitro
#4
Roberto Dircio-Maldonado, Patricia Flores-Guzman, Julieta Corral-Navarro, Ileana Mondragón-García, Alfredo Hidalgo-Miranda, Fredy Omar Beltran-Anaya, Alberto Cedro-Tanda, Lourdes Arriaga-Pizano, Odette Balvanera-Ortiz, Hector Mayani
To date, different experimental strategies have been developed for the ex vivo expansion of human hematopoietic stem (HSCs) and progenitor (HPCs) cells. This has resulted in significant advances on the use of such expanded cells in transplantation settings. To this day, however, it is still unclear to what extent those stem and progenitor cells generated in vitro retain the functional and genomic integrity of their freshly isolated counterparts. In trying to contribute to the solving of this issue, in the present study we have selected and purified three different hematopoietic cell populations: HSCs (CD34+ CD38- CD45RA- CD71- Lin- cells), myeloid progenitor cells (CD34+ CD38+ CD45RA+ CD71- Lin- cells), and erythroid progenitor cells (CD34+ CD38+ CD45RA- CD71+ Lin- cells), obtained directly from fresh human umbilical cord blood (UCB) units or generated in vitro under particular culture conditions...
April 26, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29691917/an-immunological-age-index-in-bipolar-disorder-a-confirmatory-factor-analysis-of-putative-immunosenescence-markers-and-associations-with-clinical-characteristics
#5
Lucas B Rizzo, Walter Swardfager, Pawan Kumar Maurya, Maiara Zeni Graiff, Mariana Pedrini, Elson Asevedo, Ana Cláudia Cassinelli, Moisés E Bauer, Quirino Cordeiro, Jan Scott, Elisa Brietzke, Hugo Cogo-Moreira
OBJECTIVES: The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. METHODS: Forty-four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence-related parameters were assessed: proportions of late-differentiated cells (e.g., CD3+CD8+CD28-CD27- and CD3-CD19+IgD-CD27-), and the expression of CD69, CD71, and CD152 after stimulation...
April 25, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29675416/free-floating-mesothelial-cells-in-pleural-fluid-after-lung-surgery
#6
Arne Kienzle, Andrew B Servais, Alexandra B Ysasi, Barry C Gibney, Cristian D Valenzuela, Willi L Wagner, Maximilian Ackermann, Steven J Mentzer
Objectives: The mesothelium, the surface layer of the heart, lung, bowel, liver, and tunica vaginalis, is a complex tissue implicated in organ-specific diseases and regenerative biology; however, the mechanism of mesothelial repair after surgical injury is unknown. Previous observations indicated seeding of denuded mesothelium by free-floating mesothelial cells may contribute to mesothelial healing. In this study, we investigated the prevalence of mesothelial cells in pleural fluid during the 7 days following pulmonary surgery...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29606356/tumor-induced-generation-of-splenic-erythroblast-like-ter-cells-promotes-tumor-progression
#7
Yanmei Han, Qiuyan Liu, Jin Hou, Yan Gu, Yi Zhang, Zhubo Chen, Jia Fan, Weiping Zhou, Shuangjian Qiu, Yonghong Zhang, Tao Dong, Ning Li, Zhengping Jiang, Ha Zhu, Qian Zhang, Yuanwu Ma, Lianfeng Zhang, Qingqing Wang, Yizhi Yu, Nan Li, Xuetao Cao
Identifying tumor-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding cancer as a systemic disease. Nevertheless, how primary tumor-induced non-leukocyte populations in distal organs contribute to systemic spread remains poorly defined. Here, we report one population of tumor-inducible, erythroblast-like cells (Ter-cells) deriving from megakaryocyte-erythroid progenitor cells with a unique Ter-119+ CD45- CD71+ phenotype. Ter-cells are enriched in the enlarged spleen of hosts bearing advanced tumors and facilitate tumor progression by secreting neurotrophic factor artemin into the blood...
March 28, 2018: Cell
https://www.readbyqxmd.com/read/29606255/recent-advances-in-the-physiopathology-of-iga-nephropathy
#8
Renato C Monteiro
Immunoglobulin A nephropathy or Berger's disease is the most common type of primary glomerulonephritis, which is characterized by IgA1-containing immune-deposits in the glomerular mesangium. Microscopic haematuria and proteinuria are the most common presentations. Mesangial cell proliferation with IgA deposition is found on renal biopsy. Mechanims of the disease implicate at least four key molecules have been implicated in immune complex formation: galactose-deficient IgA1, autoantibodies anti-galactose-deficient-IgA1, soluble CD89 (Fc receptor for IgA) and the CD71 mesangial IgA receptor (transferrin receptor)...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29572500/basophil-lineage-commitment-in-acute-promyelocytic-leukemia-predicts-for-severe-bleeding-after-starting-therapy
#9
Sergio Matarraz, Pilar Leoz, Carlos Fernández, Enrique Colado, María Carmen Chillón, María Belén Vidriales, Marcos González, Daniel Rivera, Carlos Salvador Osuna, Teresa Caballero-Velázquez, Vincent Van Der Velden, Mojca Jongen-Lavrencic, Oliver Gutiérrez, Ana Yeguas Bermejo, Luis García Alonso, Monique Bourgeois García, Cristina De Ramón Sánchez, Gloria García-Donas, Aránzazu García Mateo, Isabel Recio, Javier Sánchez-Real, Andrea Mayado, María Laura Gutiérrez, Paloma Bárcena, Susana Barrena, Antonio López, Jacques Van Dongen, Alberto Orfao
Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly diagnosed acute promyelocytic leukemia patients, particularly focusing on the identification of basophil-related features, and their potential association with severe bleeding episodes and patient overall survival...
March 23, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29552772/n-p-coumaroyl-serotonin-induces-cell-cycle-arrest-and-apoptosis-in-breast-cancer-cells
#10
Michail Mitsis, George A Alexiou, Evrysthenis Vartholomatos, Georgios Markopoulos, Diamanto Lazari, Entela Hodaj, Dimitrios Nastos, Panagiota Zagorianakou, Vasiliki Galani, Athanasios P Kyritsis
PURPOSE: Breast cancer is the most commonly diagnosed malignancy among women. Breast cancer cells may develop resistance to current chemotherapy, thus new chemotherapeutic agents are urgently needed. METHODS: A major number of drugs with anticancer activity have been isolated from plants. Herewith, we investigated for the first time the effect of N-(p-coumaroyl) serotonin (CS), isolated from Centaurea seed on a drug-resistant breast carcinoma (MCF-7) cells. Viability and proliferation of the cells were examined with trypan blue exclusion assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29549430/cells-with-hematopoietic-potential-reside-within-mouse-proepicardium
#11
Ewa Jankowska-Steifer, Justyna Niderla-Bielińska, Bogdan Ciszek, Marek Kujawa, Mateusz Bartkowiak, Aleksandra Flaht-Zabost, Daria Klosinska, Anna Ratajska
During embryonic development, hematopoietic cells are present in areas of blood-vessel differentiation. These hematopoietic cells emerge from a specific subpopulation of endothelial cells called the hemogenic endothelium. We have previously found that mouse proepicardium contained its own population of endothelial cells forming a network of vascular tubules. We hypothesize that this EC population contains cells of hematopoietic potential. Therefore, we investigated an in vitro hematopoietic potential of proepicardial cell populations...
March 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29505894/human-ipsc-derived-mesenchymal-stem-cells-encapsulated-in-pegda-hydrogels-mature-into-valve-interstitial-like-cells
#12
Aline L Y Nachlas, Siyi Li, Rajneesh Jha, Monalisa Singh, Chunhui Xu, Michael E Davis
Despite recent advances in tissue engineered heart valves (TEHV), a major challenge is identifying a cell source for seeding TEHV scaffolds. Native heart valves are durable because valve interstitial cells (VICs) maintain tissue homeostasis by synthesizing and remodeling the extracellular matrix. This study demonstrates that induced pluripotent stem cells (iPSC)-derived mesenchymal stem cells (iMSCs) can be derived from iPSCs using a feeder-free protocol and then further matured into VICs by encapsulation within 3D hydrogels...
April 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29495220/-study-on-apoptosis-cytochrome-c-and-mitochondrial-membrane-potential-in-cd71-nucleated-erythrocytes-in-patients-with-chronic-mountain-sickness
#13
S Y Wang, S Cui, Z Q Li, L H Ji, J Ma, H H Liu, G Y Zhang, S H Suo, R L Ge
Objective: To investigate the changes of CD71(+) nucleated erythrocyte apoptosis, cytochrome C (Cyt-C) and mitochondrial membrane potential (MMP) in bone marrow of chronic mountain sickness (CMS). Methods: 14 patients with CMS and 15 patients with simple old fracture were divided into CMS group and control group, respectively.Bone marrow mononuclear cells (BMMNC) were separated, marked with CD71 monoclonal antibody and stained with Annexin V-FITC/PI.Then the apoptotic index of CD71(+) nucleated erythrocytes was determined by flow cytometry...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29488316/receptor-ligand-and-parasite-protein-protein-interactions-in-plasmodium-vivax-analysing-rhoptry-neck-proteins-2-and-4
#14
Maritza Bermúdez, Gabriela Arévalo-Pinzón, Laura Rubio, Olivier Chaloin, Sylviane Muller, Hernando Curtidor, Manuel Alfonso Patarroyo
Elucidating receptor-ligand and protein-protein interactions represents an attractive alternative for designing effective Plasmodium vivax control methods. This article describes the ability of P. vivax rhoptry neck proteins 2 and 4 (RON2 and RON4) to bind to human reticulocytes. Biochemical and cellular studies have shown that two PvRON2- and PvRON4-derived conserved regions specifically interact with protein receptors on reticulocytes marked by the CD71 surface transferrin receptor. Mapping each protein fragment's binding region led to defining the specific participation of two 20 amino acid-long regions selectively competing for PvRON2 and PvRON4 binding to reticulocytes...
February 27, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29477874/molecular-characterization-of-%C3%AE-and-%C3%AE-thalassemia-in-the-yulin-region-of-southern-china
#15
Sheng He, Jihui Li, Dong Ming Li, Shang Yi, Xiongcai Lu, Yudi Luo, Yi Liang, Chunfeng Feng, Biyan Chen, Chenguang Zheng, Xiaoxia Qiu
Thalassemia is one of the most common hereditary blood disorders. Epidemiological data regarding the prevalence and distribution of mutations is important for planning a thalassemia control program. To reveal the prevalence of thalassemia and mutation spectrum in the Yulin region of southern China, we screened 130,318 individuals from Yulin region by hematological and genetic analysis. Totally, 24,886 (19.10%) subjects were diagnosed with thalassemia, including 16,308 (12.51%) subjects with α-thalassemia alone, 6658 (5...
May 20, 2018: Gene
https://www.readbyqxmd.com/read/29417981/immunoexpression-of-iga-receptors-cd89-cd71-in-dermatitis-herpetiformis
#16
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elzbieta Kaczmarek, Marian Dmochowski
INTRODUCTION: The role of IgA receptors in dermatitis herpetiformis (DH) pathogenesis is still unknown. CD89 and CD71 may be associated with immune response during DH development. The purpose of this study was to perform semiquantitative analysis of simultaneous immunoexpression of CD89 and CD71 in DH and IgA/neutrophil-mediated non-DH dermatoses (IgAN) in relation to specific IgA autoantibodies/antibodies (tissue and epidermal transglutaminases, nonapeptides of gliadin - eTG/tTG/npG) as well neutrophil activation via the release of neutrophil elastase (NE)...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29389020/cd71-erythroid-cells-from-neonates-born-to-women-with-preterm-labor-regulate-cytokine-and-cellular-responses
#17
Derek Miller, Roberto Romero, Ronald Unkel, Yi Xu, Felipe Vadillo-Ortega, Sonia S Hassan, Nardhy Gomez-Lopez
Neonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates...
April 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29340063/a-molecular-signature-of-dormancy-in-cd34-cd38-acute-myeloid-leukaemia-cells
#18
Mazin Gh Al-Asadi, Grace Brindle, Marcos Castellanos, Sean T May, Ken I Mills, Nigel H Russell, Claire H Seedhouse, Monica Pallis
Dormant leukaemia initiating cells in the bone marrow niche are a crucial therapeutic target for total eradication of acute myeloid leukaemia. To study this cellular subset we created and validated an in vitro model employing the cell line TF-1a, treated with Transforming Growth Factor β1 (TGFβ1) and a mammalian target of rapamycin inhibitor. The treated cells showed decreases in total RNA, Ki-67 and CD71, increased aldehyde dehydrogenase activity, forkhead box 03A (FOX03A) nuclear translocation and growth inhibition, with no evidence of apoptosis or differentiation...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29330927/defined-serum-free-medium-for-bioreactor-culture-of-an-immortalized-human-erythroblast-cell-line
#19
Esmond Lee, Zhong Ri Lim, Hong-Yu Chen, Bin Xia Yang, Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jaichandran Sivalingam, Shaul Reuveny, Yuin-Han Loh, Steve Kah-Weng Oh
Anticipated shortages in donated blood supply have prompted investigation of alternative approaches for in vitro production of red blood cells (RBCs), such as expansion of conditional immortalization erythroid progenitors. However, there is a bioprocessing challenge wherein factors promoting maximal cell expansion and growth-limiting inhibitory factors are yet to be investigated. The authors use an erythroblast cell line (ImEry) derived from immortalizing CD71+CD235a+ erythroblast from adult peripheral blood for optimization of expansion culture conditions...
January 13, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29291011/transferrin-receptor-1-upregulation-in-primary-tumor-and-downregulation-in-benign-kidney-is-associated-with-progression-and-mortality-in-renal-cell-carcinoma-patients
#20
Christopher J Greene, Kristopher Attwood, Nitika J Sharma, Kenneth W Gross, Gary J Smith, Bo Xu, Eric C Kauffman
The central dysregulated pathway of clear cell (cc) renal cell carcinoma (RCC), the von Hippel Lindau/hypoxia inducible factor-α axis, is a key regulator of intracellular iron levels, however the role of iron uptake in human RCC tumorigenesis and progression remains unknown. We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients. TfR1 immunohistochemistry was performed in over 1500 cores from 574 renal cell tumor patient tissues (primary tumors, matched benign kidneys, metastases) and non-neoplastic tissues from 36 different body sites...
December 5, 2017: Oncotarget
keyword
keyword
63580
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"