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https://www.readbyqxmd.com/read/28524813/a-multifunctional-nanocomplex-for-enhanced-cell-uptake-endosomal-escape-and-improved-cancer-therapeutic-effect
#1
Patrick V Almeida, Mohammad-Ali Shahbazi, Alexandra Correia, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
AIM: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. MATERIALS & METHODS: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. RESULTS: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemocompatibilities...
May 19, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28507843/a-new-local-flap-nipple-reconstruction-technique-using-dermal-bridge-and-preoperatively-designed-tattoo
#2
Takako Komiya, Yoshiko Iwahira
BACKGROUND: Nipple-areolar reconstruction is the final step in breast reconstruction. Reconstruction using local flaps and tattooing is useful in cases of bilateral reconstruction, a small nipple-areolar complex (NAC) as the donor site, and avoiding disturbance of the normal side and other body parts. However, this method can cause projection loss and color fading of the nipple. Moreover, the breast mound is reconstructed with an implant. METHODS: We performed nipple-areolar reconstruction of 90 nipples using clover-designed flaps oriented at 120 degrees and tattooing after breast silicone implantation in 64 women...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28497022/patients-satisfaction-with-anatomic-polyurethane-implants
#3
REVIEW
Guillermo Vázquez
This paper presents patients satisfaction using anatomical polyurethane breast implants. We performed surgery on 525 patients, 370 of which were primary and 155 were secondary to various causes such as capsular contracture, ruptured implants, volume changes, and incorrect positioning of the implant. The advantages of silicone polyurethane covers shown high level of patient satisfaction, low incidence of capsular contracture, and absence of implant rotation, and late seroma.
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497020/silicone-breast-implant-rupture-a-review
#4
REVIEW
Christopher Hillard, Jason D Fowler, Ruth Barta, Bruce Cunningham
Silicone breast implants have been in use for nearly 6 decades. In this time they have undergone significant changes in design and use. They have been subject to intense scrutiny with regard to safety and efficacy, including an almost 10 years moratorium on their use. The current generations of implants have been followed via the manufacturer's Core studies in order to obtain long term data regarding safety and complications. The results of the more recent studies are compiled in this review. Rupture rates are initially very low and begin to increase after 6-8 years of implantation...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497018/breast-implant-design
#5
REVIEW
G Patrick Maxwell, Allen Gabriel
Breast Augmentation remains as one of the most common procedures performed in the United States. This article explores the evolution of breast implants with special emphasis on the advancement of the silicone implants.
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28466365/women-with-silicone-breast-implants-and-autoimmune-inflammatory-syndrome-induced-by-adjuvants-description-of-three-patients-and-a-critical-review-of-the-literature
#6
REVIEW
Slavica Pavlov-Dolijanovic, Nada Vujasinovic Stupar
Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud's phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases)...
May 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28458972/follistatin-and-the-breast-implant-capsule
#7
Brett A Frenkiel, Peter Temple-Smith, David de Kretser, Graeme J Southwick
BACKGROUND: Breast capsular contracture remains an elusive problem faced by plastic surgeons and is the leading long-term complication after breast implantation. Follistatin (Fst) is a protein with known anti-inflammatory and antifibrotic properties and has the potential to limit the severity of diseases associated with inflammation and fibrosis such as capsular contracture. The aim of this study was to examine the effect of Fst288 on capsular fibrosis around silicone implants in a mouse model...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28457080/the-ongoing-debate-regarding-long-term-safety-of-silicone-breast-augmentation-rages
#8
EDITORIAL
Yair Levy, Noa Ruhrman-Shahar
No abstract text is available yet for this article.
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28457073/association-between-enlarged-axillary-lymph-nodes-and-silicone-breast-implant-ruptures-seen-on-magnetic-resonance-imaging
#9
Eyal Klang, Michal M Amitai, Stephen Raskin, Noa Rozendorn, Nicholas Keddel, Jana Pickovsky, Miri Sklair-Levy
BACKGROUND: Silicone breast augmentation is a common cosmetic surgery. Previous case reports demonstrated lymphadenopathy in the presence of implant ruptures. OBJECTIVES: To investigate the association between enlarged axillary lymph nodes and silicone implant ruptures as seen on breast magnetic resonance imaging (MRI). METHODS: Two groups were derived retrospectively from breast MRI reports in our institution for the period December 2011-May 2014...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28438322/water-fat-dixon-sequences-in-the-evaluation-of-breast-implants-proposal-of-a-time-effective-rapid-approach-in-the-clinical-practice
#10
M Marcon, A S Becker, E J Ulbrich, T Frauenfelder, A Boss
AIM: To evaluate the diagnostic accuracy achieved from a fat-water Dixon sequence alone compared to a combination of a silicone-specific magnetic resonance imaging (MRI) sequence and a water-specific MRI sequence in the assessment of breast implants. MATERIALS AND METHODS: In this institutional review board (IRB)-approved study the integrity of breast implants was assessed retrospectively in 27 patients undergoing breast MRI at 3 T. A qualitative evaluation of (set 1) a silicon-selective water-saturated short tau inversion recovery (STIR) sequence in combination with a water-only Dixon dataset (total acquisition time 7 minutes 17 seconds), and of (set 2) fat-only and water-only Dixon datasets (4 minutes 8 seconds) was performed by two readers independently evaluating the following features: margin definition of the implant, water suppression homogeneity, image quality, presence of artefacts and their effects on the imaging interpretation, and diagnostic confidence...
April 21, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28437235/breast-augmentation-and-reconstruction-from-a-regenerative-medicine-point-of-view-state-of-the-art-and-future-perspectives
#11
Luke E Visscher, Matthew Cheng, Mohit Chhaya, Madeline L Hintz, Jan-Thorsten Schantz, Phong Tran, Owen Ung, Clement Wong, Dietmar W Hutmacher
Breast reconstruction and augmentation are very common procedures, yet the prevailing current methods utilize silicone implants that may have significant local complications requiring reoperation. Lipofillling is increasingly used to contour and is considered safe, however, its utility is limited by significant volume loss. A new approach could offer an alternative and increase the scope of patient choice. A small number of teams around the world are investigating a breast tissue engineering (TE) paradigm. Conventional breast TE concepts are based on seeding a scaffold with the patients' own stem cells...
May 4, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28383881/a-versatile-carbonic-anhydrase-ix-targeting-ligand-functionalized-porous-silicon-nanoplatform-for-dual-hypoxia-cancer-therapy-and-imaging
#12
Agne Janoniene, Zehua Liu, Lina Baranauskiene, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni Hirvonen, Hongbo Zhang, Vilma Petrikaite, Hélder A Santos
Hypoxia occurs in most solid tumors, and it has been shown to be an independent prognostic indicator of a poor clinical outcome for patients with various cancers. Therefore, constructing a nanosystem specifically targeting cancer cells under hypoxia conditions is a promising approach for cancer therapy. Herein, we develop a porous silicon (PSi)-based nanosystem for targeted cancer therapy. VD11-4-2, a novel inhibitor for carbonic anhydrase IX (CA IX), is anchored on PSi particles (VD-PSi). As CA IX is mainly expressed on the cancer cell membrane under hypoxia condition, this nanocomplex inherits a strong affinity toward hypoxic human breast adenocarcinoma (MCF-7) cells; thus, a better killing efficiency for the hypoxia-induced drug resistance cancer cell is observed...
April 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28379860/silicone-breast-implants-and-autoimmune-rheumatic-diseases-myth-or-reality
#13
Jan Willem Cohen Tervaert, Maartje J Colaris, René R van der Hulst
PURPOSE OF REVIEW: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system...
April 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376261/theoretical-investigation-of-the-noise-performance-of-active-pixel-imaging-arrays-based-on-polycrystalline-silicon-thin-film-transistors
#14
Martin Koniczek, Larry E Antonuk, Youcef El-Mohri, Albert K Liang, Qihua Zhao
PURPOSE: Active matrix flat-panel imagers, which typically incorporate a pixelated array with one a-Si:H thin-film transistor (TFT) per pixel, have become ubiquitous by virtue of many advantages, including large monolithic construction, radiation tolerance, and high DQE. However, at low exposures such as those encountered in fluoroscopy, digital breast tomosynthesis and breast computed tomography, DQE is degraded due to the modest average signal generated per interacting x-ray relative to electronic additive noise levels of ~1000 e, or greater...
April 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28362737/depth-encoded-optical-coherence-elastography-for-simultaneous-volumetric-imaging-of-two-tissue-faces
#15
Qi Fang, Luke Frewer, Philip Wijesinghe, Wes M Allen, Lixin Chin, Juliana Hamzah, David D Sampson, Andrea Curatolo, Brendan F Kennedy
Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time...
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28347699/effect-of-adipose-derived-stem-cells-on-acellular-dermal-matrix-engraftment-in-a-rabbit-model-of-breast-reconstruction
#16
Ung Sik Jin, Ki Yong Hong, Young-Il Hwang
Acellular dermal matrix (ADM) is frequently used in implant-based breast reconstruction. Although there are several advantages, ADM implantation also increases the risk of certain complications. Recently, ADM seeded with adipose-derived stem cells (ADSCs) were shown to induce angiogenesis and improve wound healing. This study aimed to investigate the effects of ADSCs on ADM engraftment in a rabbit model of implant-based breast reconstruction. Silicone implants were inserted to submuscular pocket of 16 female New Zealand rabbits using ADM with or without seeding of fluorescent PKH26-labelled rabbit ADSCs...
June 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28342376/label-free-silicon-nanodots-featured-ratiometric-fluorescent-aptasensor-for-lysosomal-imaging-and-ph-measurement
#17
Yanan Zhang, Shan Guo, Shibo Cheng, Xinghu Ji, Zhike He
The homeostasis of lysosomal pH is crucial in cell physiology. Developing small fluorescent nanosensors for lysosome imaging and ratiometric measurement of pH is highly demanded yet challenging. Herein, a pH-sensitive fluorescein tagged aptamer AS1411 has been utilized to covalently modify the label-free fluorescent silicon nanodots via a crosslinker for construction of a ratiometric pH biosensor. The established aptasensor exhibits the advantages of ultrasmall size, hypotoxicity, excellent pH reversibility and good photostability, which favors its application in an intracellular environment...
March 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28333220/implementation-of-an-integrated-biodimensional-method-of-breast-augmentation-with-anatomic-highly-cohesive-silicone-gel-implants-short-term-results-with-the-first-620-consecutive-cases
#18
Paolo Montemurro, Mouchammed Agko, Alessandro Quattrini Li, Stefano Avvedimento, Per Hedén
Background: The previously described Akademikliniken (AK) method is a comprehensive approach to breast augmentation with form stable implants that has been shown to afford favorable outcomes when applied by experienced surgeons. Objectives: To evaluate outcomes of a surgeon newly adopting this method at the beginning of his career. Methods: A retrospective review of patients undergoing dual plane subpectoral augmentation with Style 410 implants between April 2009 and December 2014 was undertaken...
February 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28331364/silicone-induced-granuloma-of-breast-implant-capsule-sigbic-similarities-and-differences-with-anaplastic-large-cell-lymphoma-alcl-and-their-differential-diagnosis
#19
REVIEW
Eduardo de Faria Castro Fleury, Milena Morais Rêgo, Luciana Costa Ramalho, Veronica Jorge Ayres, Rodrigo Oliveira Seleti, Carlos Alberto Pecci Ferreira, Decio Roveda
Primary breast lymphoma is a rare disease and accounts for 0.5% of cases of breast cancer. Most primary breast lymphomas develop from B cells, and the involvement of T cells is rare. Anaplastic large cell lymphoma (ALCL) is a recently discovered T-cell lymphoma associated with breast implants. Only a few cases have been reported to date. It is believed that the incidence of ALCL is increasing because of the increasing number of breast implants. The clinical presentation is variable and can manifest as a palpable mass in the breast or armpit, breast pain, or capsular contracture...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28329506/n%C3%A3-dulos-subcut%C3%A3-neos-faciales-de-3-meses-de-evoluci%C3%A3-n
#20
Antonio Martinez-Lopez, Israel Pérez-Lopez, Daniel Sánchez-Cano, Ricardo Ruiz-Villaverde
Siliconomas are subcutaneous nodules that usuallyappear as a consequence of the migration of freesilicon implanted in other locations. They are morefrequent in women with abnormal breast implants,such as poly implant prostheses (PIP), but they may alsoappear after illegal injection of free silicone. We reporta 57-year-old woman who attended our Dermatologyclinic complaining of relapsing facial panniculitis ofunknown origin. After a thorough work-up, thesenodules were determined to be the consequence ofdermal filler made with fluid silicone, which had beeninjected 20 years prior...
February 15, 2017: Dermatology Online Journal
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