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Silicone breast

Qinqin Huang, Fu-Bing Wang, Chun-Hui Yuan, Zhaobo He, Lang Rao, Bo Cai, Bolei Chen, Susu Jiang, Zhiqiang Li, Jincao Chen, Wei Liu, Feng Guo, Zheng Ao, Shi Chen, Xing-Zhong Zhao
Background: Circulating tumor cells (CTCs) are a burgeoning topic in cancer biomarker discovery research with minimal invasive blood draws. CTCs can be used as potential biomarkers for disease prognosis, early cancer diagnosis and pharmacodynamics. However, the extremely low abundance of CTCs limits their clinical utility because of technical challenges such as the isolation and subsequent detailed molecular and functional characterization of rare CTCs from patient blood samples. Methods: In this study, we present a novel density gradient centrifugation method employing biodegradable gelatin nanoparticles coated on silicon beads for the isolation, release, and downstream analysis of CTCs from colorectal and breast cancer patients...
2018: Theranostics
Alireza Alikhani, Milad Gharooni, Hamed Abiri, Fatemeh Farokhmanesh, Mohammad Abdolahad
Monitoring the pH dependent behavior of normal and cancer cells by impedimetric biosensor based on Silicon Nanowires (SiNWs) was introduced to diagnose the invasive cancer cells. Autophagy as a biologically activated process in invasive cancer cells during acidosis, protect them from apoptosis in lower pH which presented in our work. As the autophagy is the only activated pathways which can maintain cellular proliferation in acidic media, responses of SiNW-ECIS in acidified cells could be correlated to the probability of autophagy activation in normal or cancer cells...
February 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Burcin Ustbas, Deniz Kilic, Ayhan Bozkurt, Mustafa Erkin Aribal, Ozge Akbulut
A silicone-based composite breast phantom is fabricated to be used as an education model in ultrasonography training. A matrix of silicone formulations is tracked to mimic the ultrasonography and tactile response of human breast tissue. The performance of two different additives: (i) silicone oil and (ii) vinyl-terminated poly (dimethylsiloxane) (PDMS) are monitored by a home-made acoustic setup. Through the use of 75 wt% vinyl-terminated PDMS in two-component silicone elastomer mixture, a sound velocity of 1...
March 2, 2018: Ultrasonics
Hina M Ismail, Chris G Pretty, Matthew K Signal, Marcus Haggers, J Geoffrey Chase
Finite element (FE) models are increasingly used to validate experimental data in breast cancer. This research constructed a biomechanical FE model for breast shaped phantoms used to develop and validate a mechanical vibration based screening system. Such models do not currently exist but would enhance development of this screening technology. Three phantoms were modelled: healthy, with 10 and 20 mm inclusions. The overall goal was to create models with enough accuracy to replace experimental phantoms in providing data to optimize diagnostic algorithms for digital image-based elasto-tomography (DIET) screening technologies...
March 10, 2018: Medical & Biological Engineering & Computing
Jae Bong Kim, Hyeon Jun Jeon, Jeong Woo Lee, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Shin-Hyung Park, Min Hee Park, Jae-Sung Bae, Jung Dug Yang
As the availability of breast reconstruction using implants is becoming widespread and many implant recipients undergo radiation therapy, there is an increasing interest in understanding the potential complications associated with capsule-tissue interactions in response to irradiation. Accordingly, our medical institution designed an animal experiment to investigate the effects of irradiation on capsular contracture. A total of 40 mice (C57BL6) were divided into four groups according to whether or not they received irradiation and the time from implantation to irradiation...
March 9, 2018: Journal of Plastic Surgery and Hand Surgery
Akiyo Yoshimura, Seiko Okumura, Masataka Sawaki, Masaya Hattori, Junko Ishiguro, Yayoi Adachi, Haruru Kotani, Naomi Gondo, Ayumi Kataoka, Madoka Iwase, Sakura Onishi, Kayoko Sugino, Mitsuo Terada, Nanae Horisawa, Makiko Mori, Nobue Takaiso, Ikuo Hyodo, Hiroji Iwata
BACKGROUND: Contralateral risk-reducing mastectomy (CRRM) for breast cancer patients with BRCA mutations has been reported to not only reduce breast cancer incidence but also to improve survival. The National Comprehensive Cancer Network guidelines recommend providing CRRM to women with BRCA mutations who desire CRRM after risk-reduction counseling. However, in Japan, CRRM cannot be performed generally because it is not covered by health insurance. Thus, we conducted a feasibility study to confirm the safety of CRRM...
March 8, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Larry S Nichter, Robert A Hardesty, Gregg M Anigian
BACKGROUND: The structured breast implant utilizes different technology than saline or silicone gel implants, making it a third type of implant. FDA and Health Canada granted approval in November 2014.This implant is filled with saline, but has an internal structure consisting of a series of nested shells that support the upper pole when upright and control fluid movement. It combines certain key features and benefits of saline and silicone gel implants. Like saline, the filler is only saline, which women like for peace of mind in case of rupture/deflation...
February 24, 2018: Plastic and Reconstructive Surgery
Robert El-Haddad, Béatrice Lafarge-Claoue, Charles Garabedian, Sylvain Staub
Objective: Observational studies are essential for ensuring patient safety, decreasing complications, and developing better surgical techniques and implants. The primary objective of this study is to demonstrate the safety and efficacy of Sebbin breast implants in both augmentation and reconstruction cohorts. Methods: This prospective, multicenter, observational 10-year study conducted in France included 205 patients (385 implants) who underwent breast augmentation (n = 166) or reconstruction (n = 39) with Sebbin round silicone gel implants...
2018: Eplasty
Yasushi Mizuno, Hiroharu Imoto, Natsuko Takahashi, Chihiro Ichikawa, Hiroaki Nishioka
No abstract text is available yet for this article.
February 27, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
D A Mendes, D F Veiga, J Veiga-Filho, A B A T Loyola, L F Paiva, N F Novo, M Sabino-Neto, L M Ferreira
Concepts regarding the best way to treat a surgical wound vary, in literature, ranging from no dressing use to dressing maintenance for 24 to 48 hours or until suture removal. This study aimed to evaluate the influence of the length of dressing maintenance after breast augmentation with implants on cutaneous colonization and surgical site infection. This is a two-arm, parallel group, randomized clinical trial. Eighty patients who were candidates for augmentation mammoplasty with silicone implants were randomly allocated to two groups, in which the dressing was removed on postoperative day 1 (group A, n = 40) or postoperative day 6 (group B, n = 40)...
February 20, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Yifei Wang, Md Azahar Ali, Edmond K C Chow, Liang Dong, Meng Lu
The rapid growth of point-of-care tests demands for biosensors with high sensitivity and small size. This paper demonstrates an optofluidic metasurface that combines silicon-on-insulator (SOI) nanophotonics and nanofluidics to realize a high-performance, lateral flow-through biosensor. The metasurface is made of a periodic array of silicon nanoposts on an SOI substrate, and functionalized with specific receptor molecules. Bonding of a polydimethylsiloxane slab directly onto the surface results in an ultracompact biosensor, where analyte solutions are restricted to flow only in the space between the nanoposts...
February 17, 2018: Biosensors & Bioelectronics
Rafael Daibert DE Souza Motta, Ana Claudia Weck Roxo, Fabio Xerfan Nahas, Fernando Serra-Guimarães
OBJECTIVES: to assess the degree of patient satisfaction after undergoing breast augmentation and compare three different, easy, inexpensive and universal methods of preoperative choice of breast implant volume. METHODS: a prospective study was carried out at University Hospital Pedro Ernesto of State University of Rio de Janeiro, in 94 women from Rio de Janeiro, aged 18 to 49 years, submitted to breast augmentation mammaplasty with breast implant due to hypomastia...
February 19, 2018: Revista do Colégio Brasileiro de Cirurgiões
Niranjan Tachamo, Anthony Donato, Bidhya Timilsina, Salik Nazir, Saroj Lohani, Rashmi Dhital, Sijan Basnet
Cosmetic injections with silicone and polymethylmethacrylate are not FDA-approved for augmentation of body parts such as breast, buttock or legs, but they have been widely used for decades. Cosmetic injections can cause foreign body granulomas and occasionally severe and life-threatening hypercalcemia. We aimed to systematically analyze the published literature on cosmetic injection-associated hypercalcemia. Methods We searched relevant articles on hypercalcemia associated with various cosmetic injections and extracted relevant data on demographics, cosmetic injections used, severity of hypercalcemia, management and outcomes...
February 16, 2018: European Journal of Endocrinology
Mark L Jewell, William P Adams
In the fourth quarter of 2017, the US FDA reviewed and approved a request by one of the breast implant manufacturers for a change in the Directions for Use (DFU) that removed warnings regarding the use of Betadine (povidone-iodine [PI] 10% solution, 1% available iodine [Purdue Frederick Company, Stamford, CT], also available in generic formulations [Aplicare, Inc., Meriden, CT]). Previously, in 2000, there were concerns by the FDA that PI would degrade the silicone elastomer shell. This change in the DFU represents an important advance that will benefit patients through the permitted use of PI to reduce the risk of bacterial contamination of implant surfaces...
February 14, 2018: Aesthetic Surgery Journal
Giuseppe Cappellano, Christian Ploner, Susanne Lobenwein, Sieghart Sopper, Paul Hoertnagl, Christina Mayerl, Nikolaus Wick, Gerhard Pierer, Georg Wick, Dolores Wolfram
The most common complication of silicone breast implants is capsular contracture (massive scar formation around the implant). We postulate that capsular contracture is always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts and macrophages have been used as cell types to evaluate in vitro the biocompatibility of breast implant surfaces. Moreover, also T cells have been found at the implant site at the initial stage of fibrous capsule formation...
2018: PloS One
Jeffery E Illman, Simone B Terra, Allison J Clapp, Katie N Hunt, Robert T Fazzio, Sejal S Shah, Katrina N Glazebrook
OBJECTIVES: This article reviews our experience and describes the literature findings of granulomatous diseases of the breast and axilla. METHODS: After approval of the Institutional Review Board was obtained, the surgical pathological records from January 2000 to January 2017 were searched for the keyword granulomatous. Clinical, imaging and histology findings were reviewed by both a fellowship-trained radiologist and a breast-imaging consultant radiologist, reviewing 127 patients (age range, 32-86 years; 126 women and 1 man)...
February 5, 2018: Insights Into Imaging
Efthymios P Papageorgiou, Hui Zhang, Bernhard E Boser, Catherine Park, Mekhail Anwar
We introduce a novel amorphous silicon absorption filter that has high rejection for all angles of incident light for wavelengths below approximately 700 nm. This filter is used for microscopic cancer tissue detection in a small intraoperative contact fluorescence imaging system that requires excitation light at oblique angles. Our 15 μm thick filter presents over five orders of magnitude rejection at 633 nm, making it compatible with several clinically tested fluorophores, including IR700DX. We have demonstrated imaging of fluorescently labeled human epidermal growth factor receptor 2+ breast cancer tissue using the filter, and we can reliably detect microscopic clusters of breast cancer cells with only a 75 ms integration time...
February 1, 2018: Optics Letters
Shin Hyuk Kang, Suk Yoon Jang, Jeong Hyun Ryou, Woo Seob Kim, Han Koo Kim, Tae Hui Bae, Mi Kyung Kim
BACKGROUND: In the field of plastic surgery, capsular contracture after silicone breast implant surgery is a major clinical problem. This experimental study confirms that the synthetic tryptophan metabolite N-(3',4'-dimethoxycinnamonyl) anthranilic acid (Tranilast) reduces capsule formation and prevents capsular contracture. METHODS: Eighteen New Zealand white rabbits were divided into 2 groups. In the experimental group, implants were inserted into each rabbit, and oral synthetic tryptophan metabolite was administered daily at a dose of 5 mg/kg in 10 mL of saline...
January 31, 2018: Annals of Plastic Surgery
Yoav Barnea, Dennis C Hammond, Yuval Geffen, Shiri Navon-Venezia, Keren Goldberg
Background: Infection and capsular contracture are two of the most significant complications of breast-implant surgery. Both complications are associated with bacterial contamination of the implant surface. Plasma activation of the surface of a silicone breast implant changes its surface properties from water repelling (hydrophobic) to water absorbing (hydrophilic), thus making it possible for antibacterial irrigants to temporarily adsorb onto the implant surface. Objective: To support our hypothesis that by changing the surface properties we could render antibacterial irrigation more effective in inhibiting bacterial growth on a breast implant shell...
January 25, 2018: Aesthetic Surgery Journal
P Castus, O Heymans, P Melin, L Renwart, C Henrist, E Hayton, S Mordon, F M Leclère
INTRODUCTION: The reinsertion of an infected implant when peri-prosthetic infection occurs early after breast augmentation or breast reconstruction remains controversial. In this experimental study, the authors tried to remove bacteria, and their biofilm, from the colonized surface of breast prostheses, without damaging their integrity. MATERIALS AND METHODS: A total of 112 shell samples of silicone breast prostheses, smooth (SPSS) and textured (TPSS), were colonized by S...
January 23, 2018: Aesthetic Plastic Surgery
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