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ORGANIC PSYCHIATRY

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https://www.readbyqxmd.com/read/28417518/what-outcomes-do-dutch-healthcare-professionals-perceive-as-important-before-participation-in-moral-case-deliberation
#1
Janine de Snoo-Trimp, Guy Widdershoven, Mia Svantesson, Riekie de Vet, Bert Molewijk
BACKGROUND: There has been little attention paid to research on the outcomes of clinical ethics support (CES) or critical reflection on what constitutes a good CES outcome. Understanding how CES users perceive the importance of CES outcomes can contribute to a better understanding, use of and normative reflection on CES outcomes. OBJECTIVE: To describe the perceptions of Dutch healthcare professionals on important outcomes of moral case deliberation (MCD), prior to MCD participation, and to compare results between respondents...
May 2017: Bioethics
https://www.readbyqxmd.com/read/28416808/ptchd1-deficiency-induces-excitatory-synaptic-and-cognitive-dysfunctions-in-mouse
#2
D C Ung, G Iacono, H Méziane, E Blanchard, M-A Papon, M Selten, J-R van Rhijn, R Montjean, J Rucci, S Martin, A Fleet, M-C Birling, S Marouillat, R Roepman, M Selloum, A Lux, R-A Thépault, P Hamel, K Mittal, J B Vincent, O Dorseuil, H G Stunnenberg, P Billuart, N Nadif Kasri, Y Hérault, F Laumonnier
Synapse development and neuronal activity represent fundamental processes for the establishment of cognitive function. Structural organization as well as signalling pathways from receptor stimulation to gene expression regulation are mediated by synaptic activity and misregulated in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability (ID). Deleterious mutations in the PTCHD1 (Patched domain containing 1) gene have been described in male patients with X-linked ID and/or ASD...
April 18, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28406368/prn-medication-administration-in-a-geriatric-psychiatric-hospital-chart-review-and-nursing-perspective
#3
Lori Harper, John R Reddon, Courtney J Hunt, Heather Royan
OBJECTIVE: To improve patient care/outcome, an evaluation was conducted of nursing procedures and protocols for pro re nata (PRN) medications. METHODS: A 14-day chart review was conducted for 27 patients with mood and thought disorders (MTD) and for 24 patients with organic disorders (OD) at a geriatric psychiatric hospital, and a questionnaire was completed by 20 nurses. RESULTS: 377 PRNs were administered to patients in the MTD and OD units (240 and 137, respectively)...
March 24, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28400639/association-of-dermatoses-with-duration-and-quantum-of-alcohol-intake-a-comparative-cross-sectional-study
#4
Yugal Kishor Sharma, Pankaj Shukla, Roopa Nayak, Preeti Kothari, Aayush Gupta
BACKGROUND: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only. AIM: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. MATERIALS AND METHODS: Adult males, totaling 196, ascertained to fulfill the Royal College of Psychiatry criteria for chronic alcoholism by the de-addiction center and referred for dermatological consult were enrolled as cases, and similar number of age-/sex-matched teetotallers, as controls...
March 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28399107/-exogenous-organic-disease-of-the-brain-is-a-paradoxical-problem-of-clinical-psychiatry
#5
B N Piven
The author considers an important issue of clinical psychiatry - mental or exogenous organic disorders. An analysis of publications of 9 Russian psychiatric journals for the period 2011-2015 and program reports of the XV and XVI Russian psychiatric congresses shows that very small attention is given to this pathology. According to the author's opinion, many aspects of this problem are unexplored or controversial. Some different interpretations of the term 'exogenous organic' makes it uninformative. There are not clear ideas about the structure of the clinical exogenous-organic disorders; their prevalence in different populations is not well studied; their combination with other mental illnesses requires further studies...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28391708/moral-insanity-and-psychological-disorder-the-hybrid-roots-of-psychiatry
#6
David W Jones
This paper traces the significance of the diagnosis of 'moral insanity' (and the related diagnoses of 'monomania' and ' manie sans délire') to the development of psychiatry as a profession in the nineteenth century. The pioneers of psychiatric thought were motivated to explore such diagnoses because they promised public recognition in the high status surroundings of the criminal court. Some success was achieved in presenting a form of expertise that centred on the ability of the experts to detect quite subtle, 'psychological' forms of dangerous madness within the minds of offenders in France and more extensively in England...
April 1, 2017: History of Psychiatry
https://www.readbyqxmd.com/read/28373691/blocking-human-fear-memory-with-the-matrix-metalloproteinase-inhibitor-doxycycline
#7
D R Bach, A Tzovara, J Vunder
Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance. On the basis of studies in cell cultures and slice preparations, it is hypothesised that synaptic remodelling required for threat learning involves the extracellular enzyme matrix metalloproteinase (MMP) 9. However, in vivo evidence for this proposal is lacking. Here we investigate human Pavlovian fear conditioning under the blood-brain barrier crossing MMP inhibitor doxycyline in a pre-registered, randomised, double-blind, placebo-controlled trial...
April 4, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28348379/genetic-evidence-for-role-of-integration-of-fast-and-slow-neurotransmission-in-schizophrenia
#8
A Devor, O A Andreassen, Y Wang, T Mäki-Marttunen, O B Smeland, C-C Fan, A J Schork, D Holland, W K Thompson, A Witoelar, C-H Chen, R S Desikan, L K McEvoy, S Djurovic, P Greengard, P Svenningsson, G T Einevoll, A M Dale
The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified hundreds of risk variants potentially implicated in the disease. Further, novel statistical methodology designed for polygenic architecture revealed more potential risk variants. This can provide a link between individual genetic factors and the mechanistic underpinnings of SCZ. Intriguingly, a large number of genes coding for ionotropic and metabotropic receptors for various neurotransmitters-glutamate, γ-aminobutyric acid (GABA), dopamine, serotonin, acetylcholine and opioids-and numerous ion channels were associated with SCZ...
March 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28347522/keep-calm-and-carry-on-mental-disorder-is-not-more-organic-than-any-other-medical-condition
#9
J A Micoulaud-Franchi, C Quiles, M Masson
Psychiatry as a discipline should no longer be grounded in the dualistic opposition between organic and mental disorders. This non-dualistic position refusing the partition along functional versus organic lines is in line with Jean Delay, and with Robert Spitzer who wanted to include in the definition of mental disorder discussed by the DSM-III task force the statement that "mental disorders are a subset of medical disorders". However, it is interesting to note that Spitzer and colleagues ingeniously introduced the definition of "mental disorder" in the DSM-III in the following statement: "there is no satisfactory definition that specifies precise boundaries for the concept "mental disorder" (also true for such concepts as physical disorder and mental and physical health)"...
March 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28337648/diagnosis-and-treatment-of-alternating-hemiplegia-of-childhood
#10
REVIEW
Melanie Masoud, Lyndsey Prange, Jeffrey Wuchich, Arsen Hunanyan, Mohamad A Mikati
The diagnosis and treatment of patients with Alternating Hemiplegia of Childhood (AHC) and related disorders should be provided by a multidisciplinary team experienced with the spectrum of presentations of this disease, with its related disorders, with its complex and fluctuating manifestations, and with cutting edge advances occurring in the field. Involvement in research to advance the understanding of this disease and partnership with international collaborators and family organizations are also important...
February 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28327856/-interinstitutional-relations-for-person-centered-health
#11
Miguel R Jorge
Since 2005, when the World Psychiatric Association has launched its Institutional Program on Psychiatry for the Person, many different organizations have worked together to advance medical care from a disease-oriented challenge to a focus centered in the whole person. Nowadays, over 30 organizations are related in promoting person-centered medicine, from which some initiatives are highlighted.
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28326745/evaluation-of-the-psychometric-properties-of-the-brief-internalized-stigma-of-mental-illness-scale-ismi-10
#12
Marie Ociskova, Jan Prasko, Dana Kamaradova, Marketa Marackova, Michaela Holubova
OBJECTIVES: A significant number of psychiatric patients stigmatize themselves because of their mental struggles. Such self-stigmatization has an adverse impact on patients' well-being and effectiveness of the treatment of mental disorders. The goal of this study was to standardize the brief Internalized Stigma of Mental Illness Scale (ISMI-10), which could be used in studies targeting the self-stigma among the psychiatric patients. METHOD: 354 psychiatric patients participated in the study between the years 2012 and 2014...
December 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28324134/-between-psyche-and-brain-state-of-the-art-in-psychiatry
#13
T Fuchs
Since its development around 1800 psychiatry has been oscillating between the poles of the sciences and the humanities, being directed towards subjective experience on the one hand and towards the neural substrate on the other hand. Today, this dualism seems to have been overcome by a naturalism, which identifies subjective experience with neural processes, according to Griesinger's frequently quoted statement "mental diseases are brain diseases". The progress achieved by the neurobiological paradigm on the level of a fundamental science is in contrast to the tendency to isolate mental illnesses from the patients' social relationships and to neglect subjectivity and intersubjectivity in their explanation...
March 21, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28289282/the-schizophrenia-and-autism-associated-gene-transcription-factor-4-regulates-the-columnar-distribution-of-layer-2-3-prefrontal-pyramidal-neurons-in-an-activity-dependent-manner
#14
S C Page, G R Hamersky, R A Gallo, M D Rannals, N E Calcaterra, M N Campbell, B Mayfield, A Briley, B N Phan, A E Jaffe, B J Maher
Disruption of the laminar and columnar organization of the brain is implicated in several psychiatric disorders. Here, we show in utero gain-of-function of the psychiatric risk gene transcription factor 4 (TCF4) severely disrupts the columnar organization of medial prefrontal cortex (mPFC) in a transcription- and activity-dependent manner. This morphological phenotype was rescued by co-expression of TCF4 plus calmodulin in a calcium-dependent manner and by dampening neuronal excitability through co-expression of an inwardly rectifying potassium channel (Kir2...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28287191/-history-of-clinical-psychiatry-of-sapienza-university-of-rome-in-policlinico-umberto-i
#15
Maria Antonietta Coccanari De' Fornari, Angela Iannitelli, Massimo Biondi
The present article intends to go over the history of the Psychiatric Clinic of the Sapienza University of Rome, starting from the beginning of the teaching of Psychiatry at Santa Maria della Pietà mental hospital, back in 1871, to the eventual founding, at the University "La Sapienza" and the Umberto I general hospital, of the Institute of Psychiatric Clinic and next of the Nervous and Mental Diseases' Clinic with the enclosed specialization school in Psychiatry. A detailed overview is supplied on the characters of the eminent scientists who have succeeded over time at the head of the Clinic and on the description of its different organization, conceived by each of them because of their educational and cultural roots...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28267146/new-dimensions-and-new-tools-to-realize-the-potential-of-rdoc-digital-phenotyping-via-smartphones-and-connected-devices
#16
J Torous, J-P Onnela, M Keshavan
Mobile and connected devices like smartphones and wearable sensors can facilitate the collection of novel naturalistic and longitudinal data relevant to psychiatry at both the personal and population level. The National Institute of Mental Health's Research Domain Criteria framework offers a useful roadmap to organize, guide and lead new digital phenotyping data towards research discoveries and clinical advances.
March 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28262169/effect-of-call-organization-on-burnout-and-quality-of-life-in-psychiatry-residents
#17
Timothy M Scarella, Julia Nelligan, Jacqueline Roberts, Robert J Boland
We aimed to measure the effects of a residency program's mid-year shift from 24-h call to night float on resident burnout and quality of life. At the end of the year, residents who started the year with 24-h call had worse burnout and quality of life, with statistical significance and large effect sizes. Exposure to a twenty-four hour call system, when compared to a full year of night float, may be associated with increased burnout and decreased quality of life, though measuring this effect is not straightforward...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28221900/mental-health-disorders-associated-with-foodborne-pathogens
#18
Declan J Bolton, Lucy J Robertson
Human infections with foodborne pathogenic organisms are relatively well described in terms of their overt physical symptoms, such as diarrhea, abdominal cramps, vomiting, fever, and associated sequelae. Indeed, some of these are key for diagnosis and treatment, although it should be noted that, for some foodborne pathogens, the physical symptoms might be more diffuse, particularly those associated with some of the foodborne parasites. In contrast, the impact of these pathogens on mental health is less well described, and symptoms such as depression, anxiety, and general malaise are usually ignored when foodborne infections are recorded...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28202296/psychosis-in-the-ed-a-case-of-nmda-receptor-antibody-encephalitis
#19
Joseph Fisher, Clifford Ellingson, Noah Tolby
Anti-N-methyl-d-aspartate antibody receptor (NMDAR) encephalitis is a newly recognized disease increasing in diagnostic frequency. A 27-year-old female presented with symptoms of oral dyskinesia, tachycardia, and altered mental status following a three-month history of depression, lethargy, catatonia, and auditory hallucinations. We utilized our facilities neurology and psychiatry consult services, performed a lumbar puncture (LP), and requested NMDAR antibody titers. Following admission the Anti-NMDAR antibody titer was elevated warranting treatment with intravenous immunoglobulin (IVIG), corticosteroids, and later rituximab...
February 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28162191/-the-chinese-expert-consensus-on-clinical-practice-of-medically-unexplained-symptoms
#20
(no author information available yet)
"Medically unexplained symptoms" (MUS) are commonly seen in all clinical specialties. The preliminary investigations in China show a prevalence of MUS in 4.15%-18.2% of clinical patients. Based on international and national guidelines and the most advanced studies, a Chinese expert consensus on clinical practice of MUS is reached through three rounds of discussion seminars by 25 experts from various specialties including psychiatry, internal medicine, surgery, gynecology-obstetrics, otorhinolar-yngology and traditional Chinese medicine...
February 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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