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https://www.readbyqxmd.com/read/28211878/pre-descemets-endothelial-keratoplasty-the-pdek-clamp-for-successful-pdek
#1
H S Dua, D G Said
PurposeTo design and produce a clamp that enables good handling of donor sclera-corneal disks, allows air to be injected in the corneal stroma and consistently provides pre-Descemets endothelial keratoplasty (PDEK) tissue by creation of a type-1 big bubble (BB) avoiding a type-2BB by shutting the fenestrations in the periphery of the pre-Descemets layer and preventing escape of air.Patients and methodsA clamp with spring loaded handles attached to two rings of 9 mm diameter and 1 mm width with a side port for insertion of a needle for air injection was designed and produced...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28210178/a-steep-peripheral-ring-in-irregular-cornea-topography-real-or-an-instrument-error
#2
Alicia Galindo-Ferreiro, Alberto Galvez-Ruiz, Silvana A Schellini, Julio Galindo-Alonso
PURPOSE: To demonstrate that the steep peripheral ring (red zone) on corneal topography after myopic laser in situ keratomileusis (LASIK) could possibly due to instrument error and not always to a real increase in corneal curvature. METHODS: A spherical model for the corneal surface and modifying topography software was used to analyze the cause of an error due to instrument design. This study involved modification of the software of a commercially available topographer...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28194552/a-novel-synthetic-small-molecule-yf-452-inhibits-tumor-growth-through-antiangiogenesis-by-suppressing-vegf-receptor-2-signaling
#3
Yongrui Liu, Yuan He, Feifei Yang, Xiaonan Cong, Jinhua Wang, Shihong Peng, Dan Gao, Weifang Wang, Liping Lan, Xuexiang Ying, Mingyao Liu, Yihua Chen, Zhengfang Yi
Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway...
February 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28192590/tomographic-findings-after-implantation-of-ferrara-intrastromal-corneal-ring-segments-in-keratoconus
#4
João Marcelo Lyra, Daniela Lyra, Guilherme Ribeiro, Leonardo Torquetti, Paulo Ferrara, Aydano Machado
PURPOSE: To analyze and compare changes to the anterior and posterior corneal surfaces after Ferrara intracorneal ring segment (ICRS) (AJL, Boecillo, Spain) implantation and to correlate those changes with visual outcomes. METHODS: This retrospective case series study comprised consecutive patients with keratoconus implanted with the Ferrara ICRS. Computed tomography scans of the two corneal surfaces were obtained preoperatively and postoperatively with a rotating Scheimpflug imaging system...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28165027/potential-role-of-corneal-epithelial-cell-derived-exosomes-in-corneal-wound-healing-and-neovascularization
#5
Kyu-Yeon Han, Jennifer A Tran, Jin-Hong Chang, Dimitri T Azar, James D Zieske
Specific factors from the corneal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated. Given that exosomes are known to transfer bioactive molecules among cells and play crucial roles in wound healing, angiogenesis, and cancer, we hypothesized that corneal epithelial cell-derived exosomes may gain access to the underlying stromal fibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events essential for corneal wound healing...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28125853/post-lens-tear-turbidity-and-visual-quality-after-scleral-lens-wear
#6
Gonzalo Carracedo, Maria Serramito-Blanco, Alba Martin-Gil, Zicheng Wang, Candela Rodriguez-Pomar, Jesús Pintor
BACKGROUND: The aim was to evaluate the turbidity and thickness of the post-lens tear layer and its effect on visual quality in patients with keratoconus after the beginning of lens wear and before lens removal at the end of eight hours. METHODS: Twenty-six patients with keratoconus (aged 36.95 ± 8.95 years) participated voluntarily in the study. The sample was divided into two groups: patients with intrastromal corneal ring (ICRS group) and patients without ICRS (KC group)...
January 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28109903/an-apposition-compound-eye-adapted-for-nocturnal-vision-in-the-moth-midge-clogmia-albipunctata-williston-diptera-psychodidae
#7
Lei-Po Jia, Ai-Ping Liang
Morphology and anatomy, dark/light adaptational changes and optics of the compound eyes of the nocturnal moth midge Clogmia albipunctata (Williston) are studied. Its apposition type of eye consists of approximately 260 well-separated ommatidia. Each ommatidium features a biconvex corneal lens covered by corneal nipples measuring around 17nm in height; a crystalline cone of the acone type; and an open (laterally fused) rhabdom formed by eight retinular cells (R1-R8). The corneal lens, whose biological significance is addressed, is composed of a thick yellow-coloured inner lens unit (ILU) surrounded by a thin, colourless outer lens unit (OLU)...
January 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28096650/refractive-and-visual-outcomes-after-keraring-intrastromal-corneal-ring-segment-implantation-for-keratoconus-assisted-by-femtosecond-laser-at-6-months-follow-up
#8
Mohamed A Heikal, Marwa Abdelshafy, Tarek T Soliman, Abdelmonem M Hamed
PURPOSE: We attempted to evaluate the efficacy of femtosecond laser-assisted intrastromal corneal ring segment implantation in patients with keratoconus (KC). PATIENTS AND METHODS: A retrospective interventional consecutive clinical study was conducted on patients with KC who were treated with femtosecond laser Keraring implantation. All procedures were performed at Ebsar Eye Center in the period from January 5, 2015, to February 28, 2016. RESULTS: Thirty eyes of 20 patients were included in this study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#9
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28068449/repeated-cross-linking-after-a-short-time-does-not-provide-any-additional-biomechanical-stiffness-in-the-mouse-cornea-in-vivo
#10
David Tabibian, Sabine Kling, Arthur Hammer, Olivier Richoz, Farhad Hafezi
PURPOSE: To study whether repeated collagen cross-linking (CXL) performed in vivo in mice shows an additive effect on mechanical corneal stiffness. METHODS: In this experimental study, epithelium-off CXL was performed in a total of 18 eyes from male C57BL/6 mice, with 0.27%-riboflavin solution applied for 20 minutes, followed by ultraviolet-A (UVA) irradiation (365 nm, 9mW/cm(2)) for 2:50 minutes (fluence 1.53 J/cm(2)). CXL was performed as either a single (1×CXL) or a repeated (2×CXL) treatment...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28060075/removal-and-repositioning-of-intracorneal-ring-segments-improving-corneal-topography-and-clinical-outcomes-in-keratoconus-and-ectasia
#11
Kahei Chan, Peter S Hersh
PURPOSE: To evaluate the efficacy of removal and relocation of intracorneal ring segments for improving outcomes in treatment of keratoconus and corneal ectasia. METHODS: This is a retrospective case series conducted at a cornea and refractive surgery subspecialty practice setting. Patients with previous insertion of 2 intracorneal ring segments underwent surgical removal and repositioning of segments because of unsatisfactory visual and topographic outcomes. The principal outcomes included uncorrected and corrected visual acuities, manifest refraction, topography-derived maximum keratometry (Kmax), inferior-superior topography power difference (I - S), and higher-order aberration profile derived from wavefront analysis...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060059/efficacy-of-intrastromal-corneal-ring-segments-combined-with-flash-collagen-cross-linking-in-keratoconus
#12
Carlos H Gordillo, Juan C Grandin, Roger Zaldivar, Roberto Zaldivar, Adriana C Lotfi
PURPOSE: To evaluate outcomes, efficacy, and safety of intrastromal corneal ring segment implantation for treatment of keratoconus combined with collagen cross-linking (CXL) with 1-year follow-up. METHODS: One hundred nineteen eyes of 82 patients with keratoconus (37 females) underwent femtosecond (Intralase FS; Abbott Medical Optics, Inc) laser-assisted intrastromal corneal ring segment implantation (INTRASEG; Gamma Vision) with flash CXL (18 mW/cm for 5 minutes)...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060027/advantages-of-anterior-segment-optical-coherence-tomography-evaluation-of-the-kayser-fleischer-ring-in-wilson-disease
#13
Mittanamalli S Sridhar
PURPOSE: To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT. METHODS: This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent slit-lamp examination of the cornea and AS-OCT (Optovue RTVue Premier)...
March 2017: Cornea
https://www.readbyqxmd.com/read/28009397/corneal-collagen-crosslinking-for-corneal-ectasias-a-review
#14
David P S O'Brart
PURPOSE: To review the published literature on corneal collagen crosslinking (CXL). METHODS: Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. RESULTS: Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements...
December 6, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28005433/combined-special-capsular-tension-ring-and-toric-iol-implantation-for-management-of-astigmatism-and-high-axial-myopia-with-cataracts
#15
Yang Zhao, Jiaxin Li, Ke Yang, Xiao Li, Siquan Zhu
AIM: This study aimed to compare the effects of toric intraocular lens (IOL) implantation with a capsular tension ring and toric IOL implantation only in patients with axial myopic astigmatism who had undergone cataract surgery. METHODS: Of 34 patients with axial myopia, 16 patients who had received IOL and capsular tension ring (CTR) implantation were included in the combined group and 18 patients who received toric IOL implantation only were included in the simple group...
December 22, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27984365/mid-term-results-of-a-single-intrastromal-corneal-ring-segment-for-mild-to-moderate-progressive-keratoconus
#16
Mohammad Miraftab, Hassan Hashemi, Farhad Hafezi, Soheila Asgari
PURPOSE: To study the mid-term effects of implanting a single intracorneal ring segment (ICRS) for treatment of mild to moderate progressive keratoconus. METHODS: This retrospective study was conducted on patients with progressive keratoconus treated with ICRS. The mean follow-up time was 15.2 ± 8.8 (range, 7-26) months before and 27.8 ± 7.5 (range, 18-35) months after surgery. Patients received no other treatment during this time. Of the cases studied, 59.1% had inferior keratoconus...
December 14, 2016: Cornea
https://www.readbyqxmd.com/read/27984362/efficacy-of-intrastromal-corneal-ring-segments-combined-with-flash-collagen-cross-linking-in-keratoconus
#17
Carlos H Gordillo, Juan C Grandin, Roger Zaldivar, Roberto Zaldivar, Adriana C Lotfi
PURPOSE: To evaluate outcomes, efficacy, and safety of intrastromal corneal ring segment implantation for treatment of keratoconus combined with collagen cross-linking (CXL) with 1-year follow-up. METHODS: One hundred nineteen eyes of 82 patients with keratoconus (37 females) underwent femtosecond (Intralase FS; Abbott Medical Optics, Inc) laser-assisted intrastromal corneal ring segment implantation (INTRASEG; Gamma Vision) with flash CXL (18 mW/cm for 5 minutes)...
December 14, 2016: Cornea
https://www.readbyqxmd.com/read/27930793/intracorneal-ring-segments-implantation-for-corneal-ectasia
#18
Natalia T Giacomin, Glauco R Mello, Carla S Medeiros, Alyin Kiliç, Cristine C Serpe, Hirlana G Almeida, Newton Kara-Junior, Marcony R Santhiago
PURPOSE: To provide an overview of the predictability, safety, and efficacy of intrastromal corneal ring segment (ICRS) implantation as a tool to improve visual acuity and its association with other techniques such as corneal collagen cross-linking (CXL), addressing biomechanical outcomes, models, surgical planning and technique, indications, contraindications, and complications in ectatic corneas. METHODS: Literature review. RESULTS: ICRSs have been used to regularize the corneal shape and reduce corneal astigmatism and higher order aberrations, improve visual acuity to acceptable limits, and delay, or eventually prevent, a corneal keratoplasty in keratoconic eyes...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27918353/removal-and-repositioning-of-intracorneal-ring-segments-improving-corneal-topography-and-clinical-outcomes-in-keratoconus-and-ectasia
#19
Kahei Chan, Peter S Hersh
PURPOSE: To evaluate the efficacy of removal and relocation of intracorneal ring segments for improving outcomes in treatment of keratoconus and corneal ectasia. METHODS: This is a retrospective case series conducted at a cornea and refractive surgery subspecialty practice setting. Patients with previous insertion of 2 intracorneal ring segments underwent surgical removal and repositioning of segments because of unsatisfactory visual and topographic outcomes. The principal outcomes included uncorrected and corrected visual acuities, manifest refraction, topography-derived maximum keratometry (Kmax), inferior-superior topography power difference (I - S), and higher-order aberration profile derived from wavefront analysis...
December 1, 2016: Cornea
https://www.readbyqxmd.com/read/27911382/a-simple-mechanical-procedure-to-create-limbal-stem-cell-deficiency-in-mouse
#20
Neda Afsharkhamseh, Elham Ghahari, Medi Eslani, Ali R Djalilian
Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with conjunctiva. Patients suffer from recurrent corneal defects, pain, inflammation, and loss of vision. Previously, a murine model of LSCD was described and compared to two other models. The goal was to produce a consistent mouse model of LSCD that both mimics the phenotype in humans and lasts long enough to make it possible to study the disease pathophysiology and to evaluate new treatments...
November 17, 2016: Journal of Visualized Experiments: JoVE
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