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https://www.readbyqxmd.com/read/29128643/transcriptional-profiles-of-plasticity-for-desiccation-stress-in-drosophila
#1
Allannah S Clemson, Carla M Sgrò, Marina Telonis-Scott
We examined the transcriptional responses of desiccation resistance candidate genes in populations of Drosophila melanogaster divergent for desiccation resistance and in capacity to improve resistance via phenotypic plasticity. Adult females from temperate and tropical eastern Australian populations were exposed to a rapid desiccation hardening (RDH) treatment, and groups without RDH to acute desiccation stress, and temporally profiled transcript expression of 12 candidate desiccation genes during, and in recovery from stress...
November 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29123984/transmembrane-thioredoxin-related-protein-tmx1-is-reversibly-oxidized-in-response-to-protein-accumulation-in-the-endoplasmic-reticulum
#2
Yoshiyuki Matsuo, Kiichi Hirota
Numerous secretory and membrane proteins undergo post-translational modifications in the endoplasmic reticulum (ER), and the formation of disulfide bonds is a modification that is critical for proper protein folding. The mammalian ER contains a large family of oxidoreductases that are considered to catalyze thiol/disulfide exchange and ensure the maintenance of a redox environment within the ER. Disruption of ER homeostasis causes an accumulation of misfolded and unfolded proteins, a condition termed ER stress...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29083257/a-combination-antioxidant-therapy-to-inhibit-nox2-and-activate-nrf2-decreases-secondary-brain-damage-and-improves-functional-recovery-after-traumatic-brain-injury
#3
Raghavendar Chandran, TaeHee Kim, Suresh L Mehta, Eshwar Udho, Vishal Chanana, Pelin Cengiz, HwuiWon Kim, Chanul Kim, Raghu Vemuganti
Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both NADPH oxidase 2 (NOX2) that increases and transcription factor Nrf2 that decreases reactive oxygen species (ROS) are induced after TBI. As the post-injury functional outcome depends on the balance of these opposing molecular pathways, we evaluated the effect of TBI on the motor and cognitive deficits and cortical contusion volume in NOX2 and Nrf2 knockout mice...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29037399/comparison-of-heat-strain-recovery-in-different-anti-heat-stress-clothing-ensembles-after-work-to-exhaustion
#4
Yijie Zhao, Wen Yi, Albert P C Chan, Daniel W M Chan
A hot environment combined with physically demanding tasks can subject workers to a higher risk of heat stress. A series of regulations and guidelines have been proposed to design appropriate anti-heat stress work uniform to reduce body heat strain. The present study aimed to examine heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion in the heat. 10 healthy males performed intermittent treadmill running/walking to exhaustion, followed by 30min passive recovery sitting in a climatic chamber, which simulated the hot and humid outdoor environment (34°C temperature, 60% relative humidity, 0...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29017969/vigorous-exercise-mobilizes-cd34-hematopoietic-stem-cells-to-peripheral-blood-via-the-%C3%AE-2-adrenergic-receptor
#5
Nadia H Agha, Forrest L Baker, Hawley E Kunz, Rachel Graff, Rod Azadan, Chad Dolan, Mitzi S Laughlin, Chitra Hosing, Melissa M Markofski, Richard A Bond, Catherine M Bollard, Richard J Simpson
Acute dynamic exercise mobilizes CD34+ hematopoietic stem cells (HSCs) to the bloodstream, potentially serving as an economical adjuvant to boost the collection of HSCs from stem cell transplant donors. The mechanisms responsible for HSC mobilization with exercise are unknown but are likely due to hemodynamic perturbations, endogenous granulocyte-colony stimulating factor (G-CSF), and/or β2-adrenergic receptor (β2-AR) signaling. We characterized the temporal response of HSC mobilization and plasma G-CSF following exercise, and determined the impact of in vivo β-AR blockade on the exercise-induced mobilization of HSCs...
October 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28942275/castasterone-confers-copper-stress-tolerance-by-regulating-antioxidant-enzyme-responses-antioxidants-and-amino-acid-balance-in-b-juncea-seedlings
#6
Poonam Yadav, Ravdeep Kaur, Mukesh Kumar Kanwar, Anket Sharma, Vinod Verma, Geetika Sirhindi, Renu Bhardwaj
The aim of the present study was to explore the effect of exogenous application of castasterone (CS) on physiologic and biochemical responses in Brassica juncea seedlings under copper (Cu) stress. Seeds were pre-soaked in different concentrations of CS and grown for 7 days under various levels of Cu. The exposure of B. juncea to higher levels of Cu led to decrease of morphologic parameters, with partial recovery of length and fresh weight in the CS pre-treated seedlings. Metal content was high in both roots and shoots under Cu exposure while the CS pre-treatment reduced the metal uptake...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28899584/evaluating-the-past-to-improve-the-future-a-qualitative-study-of-icu-patients-experiences
#7
Kristin Dahle Olsen, Marit Nester, Britt Sætre Hansen
BACKGROUND: The recovery period for patients who have been in an intensive care unitis often prolonged and suboptimal. Anxiety, depression and post-traumatic stress disorder are common psychological problems. Intensive care staff offer various types of intensive aftercare. Intensive care follow-up aftercare services are not standard clinical practice in Norway. OBJECTIVE: The overall aim of this study is to investigate how adult patients experience theirintensive care stay their recovery period, and the usefulness of an information pamphlet...
September 9, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28890580/the-role-of-compost-in-stabilizing-the-microbiological-and-biochemical-properties-of-zinc-stressed-soil
#8
Rafał Strachel, Jadwiga Wyszkowska, Małgorzata Baćmaga
The progressive development of civilization and intensive industrialization has contributed to the global pollution of the natural environment by heavy metals, especially the soil. Degraded soils generally contain less organic matter, and thus, their homeostasis is more often disturbed, which in turn manifests in changes in biological and physicochemical properties of the soil. Therefore, new possibilities and solutions for possible neutralization of these contaminations are sought, inter alia, through reclamation of degraded land...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28846122/single-osteopathic-manipulative-therapy-session-dampens-acute-autonomic-and-neuroendocrine-responses-to-mental-stress-in-healthy-male-participants
#9
Mauro Fornari, Luca Carnevali, Andrea Sgoifo
Context: The efficacy of osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) is supported by observational data and patient feedback, but there is still a need for objective, quantitative biomarkers that allow measurement of the underlying mechanisms. No study exploring the protective potential of OMTh for mental stress has been published, to the authors' knowledge. Objectives: To explore the modulating effect of OMTh on autonomic neural regulation of the heart and verifiy its ability to influence the activity of the hypothalmic-pituitary-adrenocortical axis...
September 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28841765/enabling-a-disaster-resilient-workforce-attending-to-individual-stress-and-collective-trauma
#10
Victoria H Raveis, Nancy VanDevanter, Christine T Kovner, Robyn Gershon
PURPOSE: Superstorm Sandy forced the evacuation and extended shutdown of New York University Langone Medical Center. This investigation explored how nurses were impacted by the disasters and how they can best be supported in their nursing responsibilities. DESIGN: Sequential mixed methods were used to explore the psychosocial issues nurses experienced throughout the course of this natural disaster and its lingering aftermath. METHODS: In-depth interviews were conducted from April to June 2013 with a subsample of nurses who participated in the evacuation deployment (n = 16)...
August 25, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28771098/physical-preparation-recommendations-for-elite-rugby-sevens-performance
#11
Jake Schuster, Dan Howells, Julien Robineau, Anthony Couderc, Alex Natera, Nick Lumley, Tim J Gabbett, Nick Winkelman
Rugby Sevens, a new Olympic sport, features high intensity intermittent running and contact efforts over short match durations, normally six times across two to three days in a tournament format. Elite Rugby Sevens seasons often include over a dozen competitive tournaments across less than nine months, demanding deliberate and careful training-stress balance and workload management alongside development of the necessary physical qualities required for competition. Focus on running and repeated power skills, strength, and match-specific conditioning capacities is advised...
August 3, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28741153/recovery-of-acl-function-after-dynamic-intraligamentary-stabilization-is-resultant-to-restoration-of-acl-integrity-and-scar-tissue-formation
#12
Atesch Ateschrang, Sufian S Ahmad, Ulrich Stöckle, Steffen Schroeter, Willem Schenk, Marc Daniel Ahrend
PURPOSE: Dynamic intraligamentary stabilization (DIS) is recognized as a ligament preserving technique for the treatment of acute anterior cruciate ligament (ACL) injuries. The aim of this study was to assess the integrity and morphology of the recovered ACL after DIS repair. METHODS: The cohort comprised 47 patients with an acute proximal ACL rupture undergoing DIS repair. All patients underwent diagnostic arthroscopy after a minimum postoperative interval of 6 months for semi-quantitative evaluation of ACL integrity, function and scar tissue formation...
July 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28690573/changes-of-swimmers-emotional-states-during-the-preparation-of-national-championship-do-recovery-stress-states-matter
#13
Philippe Vacher, Michel Nicolas, Guillaume Martinent, Laurent Mourot
This study examined the trajectories of emotional states and their within-person synergies with perceived stress and recovery during a 4-month training period preceding the French swimming championships. A Multilevel Growth Curve Analysis approach was used with 16 high level swimmers. Five waves of assessments of emotional states, perceived stress and recovery were completed. Results indicated that emotional states were characterized by distinct trajectories during the training period preceding a major competition...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28662152/does-external-pneumatic-compression-treatment-between-bouts-of-overreaching-resistance-training-sessions-exert-differential-effects-on-molecular-signaling-and-performance-related-variables-compared-to-passive-recovery-an-exploratory-study
#14
Cody T Haun, Michael D Roberts, Matthew A Romero, Shelby C Osburn, Christopher B Mobley, Richard G Anderson, Michael D Goodlett, David D Pascoe, Jeffrey S Martin
PURPOSE: We sought to compare the effects of external pneumatic compression (EPC) and sham when used concurrently with resistance training on performance-related outcomes and molecular measures related to recovery. METHODS: Twenty (N = 20) resistance-trained male participants (aged 21.6±2.4 years) were randomized to balanced sham or EPC intervention groups. The protocol consisted of 3 consecutive days of heavy, voluminous back squat exercise followed by EPC/sham treatment (Days2-4) and 3 consecutive days of recovery (Days5-7) with EPC/sham only on Days5-6...
2017: PloS One
https://www.readbyqxmd.com/read/28632902/impaired-hippocampal-glucose-metabolism-during-and-after-flurothyl-induced-seizures-in-mice-reduced-phosphorylation-coincides-with-reduced-activity-of-pyruvate-dehydrogenase
#15
Tanya S McDonald, Karin Borges
OBJECTIVE: To determine changes in glucose metabolism and the enzymes involved in the hippocampus ictally and postictally in the acute mouse flurothyl seizure model. METHODS: [U-(13) C]-Glucose was injected (i.p.) prior to, or following a 5 min flurothyl-induced seizure. Fifteen minutes later, mice were killed and the total metabolite levels and % (13) C enrichment were analyzed in the hippocampal formation using gas chromatography-mass spectrometry. Activities of key metabolic and antioxidant enzymes and the phosphorylation status of pyruvate dehydrogenase were measured, along with lipid peroxidation...
July 2017: Epilepsia
https://www.readbyqxmd.com/read/28614117/role-of-amp-activated-protein-kinase-in-kidney-tubular-transport-metabolism-and-disease
#16
Roshan Rajani, Nuria M Pastor-Soler, Kenneth R Hallows
PURPOSE OF REVIEW: AMP-activated protein kinase (AMPK) is a metabolic sensor that regulates cellular energy balance, transport, growth, inflammation, and survival functions. This review explores recent work in defining the effects of AMPK on various renal tubular epithelial ion transport proteins as well as its role in kidney injury and repair in normal and disease states. RECENT FINDINGS: Recently, several groups have uncovered additional functions of AMPK in the regulation of kidney and transport proteins...
September 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28597618/effects-of-resistance-training-overtraining-and-early-specialization-on-youth-athletes
#17
Benjamin K Walters, Connor R Read, A Reed Estes
INTRODUCTION: In 2014, 60 million youth ages 6-18 participated in some form of generalized athletics. 3.5 million children are injured annually participating in organized sport or recreational activities. While sound physical education can decrease the burden of youth sports injuries, the median annual physical education budget of $764 for United States elementary, middle and high schools may not allow enough flexibility to apply evidenced-based guidelines. EVIDENCE ACQUISITION: The topics were selected after a careful review of the 2016 National Strength and Conditioning Association Position Statement on Long-Term Athletic Development...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28595610/the-efficacy-and-safety-of-danggui-sayuk-ga-osuyu-saenggang-tang-on-korean-patients-with-cold-hypersensitivity-in-the-hands-study-protocol-for-a-pilot-double-blind-randomized-placebo-controlled-parallel-group-clinical-trial
#18
Youme Ko, Ho-Yeon Go, Yoon-Young Cho, Ji-Hye Shin, Tae-Hoon Kim, Dong-Jun Choi, Jin-Moo Lee, Jun-Bok Jang, Yun-Kyung Song, Seong-Gyu Ko, Seung-Ho Sun, Chan-Yong Jeon
BACKGROUND: In recent years, cold hypersensitivity in the hands (CHH) has become a common ailment of women in Korea. It can lead to gynecological problems such as irregular menstruation, miscarriage, and infertility. Traditionally, Korean herbal medicine has been the primary treatment method used to balance thermoregulation in the human body; however, its effectiveness has not been confirmed through systematic study. Thus, in this trial, we will investigate the feasibility of a full randomized clinical trial, Danggui-Sayuk-Ga-Osuyu-Saenggang-tang (DSGOST) in Korean women with CHH...
June 8, 2017: Trials
https://www.readbyqxmd.com/read/28590761/proteome-wide-adaptations-of-mouse-skeletal-muscles-during-a-full-month-in-space
#19
Georg Tascher, Thomas Brioche, Pauline Maes, Angèle Chopard, Donal O'Gorman, Guillemette Gauquelin-Koch, Stéphane Blanc, Fabrice Bertile
The safety of space flight is challenged by a severe loss of skeletal muscle mass, strength, and endurance that may compromise the health and performance of astronauts. The molecular mechanisms underpinning muscle atrophy and decreased performance have been studied mostly after short duration flights and are still not fully elucidated. By deciphering the muscle proteome changes elicited in mice after a full month aboard the BION-M1 biosatellite, we observed that the antigravity soleus incurred the greatest changes compared with locomotor muscles...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28539916/endophytic-fungi-piriformospora-indica-mediated-protection-of-host-from-arsenic-toxicity
#20
Shayan Mohd, Jagriti Shukla, Aparna S Kushwaha, Kapil Mandrah, Jai Shankar, Nidhi Arjaria, Prem N Saxena, Ram Narayan, Somendu K Roy, Manoj Kumar
Complex intercellular interaction is a common theme in plant-pathogen/symbiont relationship. Cellular physiology of both the partners is affected by abiotic stress. However, little is known about the degree of protection each offers to the other from different types of environmental stress. Our current study focused on the changes in response to toxic arsenic in the presence of an endophytic fungus Piriformospora indica that colonizes the paddy roots. The primary impact of arsenic was observed in the form of hyper-colonization of fungus in the host root and resulted in the recovery of its overall biomass, root damage, and chlorophyll due to arsenic toxicity...
2017: Frontiers in Microbiology
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