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https://www.readbyqxmd.com/read/29765406/the-differentiation-balance-of-bone-marrow-mesenchymal-stem-cells-is-crucial-to-hematopoiesis
#1
REVIEW
Jiang Wu, Weiwei Zhang, Qian Ran, Yang Xiang, Jiang F Zhong, Shengwen Calvin Li, Zhongjun Li
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29704570/proteomic-analysis-of-the-effect-of-plant-derived-smoke-on-soybean-during-recovery-from-flooding-stress
#2
Xinyue Li, Shafiq Ur Rehman, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Takuya Yamaguchi, Yukari Sunohara, Hiroshi Matsumoto, Setsuko Komatsu
Flooding negatively affects the growth of soybean, whereas the plant-derived smoke enhances seedling growth of crops. To clarify the mechanism underlying the recovery from flooding stress, proteomic analysis was performed based on morphological results. Growth of soybean seedlings was inhibited under flooding stress, but it recovered after water removal following treatment with plant-derived smoke. Sucrose/starch metabolism and glycolysis were suppressed in smoke-treated flooded soybean compared to flooded soybean...
April 25, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684504/schwann-cell-plasticity-is-regulated-by-a-weakened-intrinsic-antioxidant-defense-system-in-acute-peripheral-nerve-injury
#3
Wenjing Lv, Binbin Deng, Weisong Duan, Yuanyuan Li, Yakun Liu, Zhongyao Li, Wei Xia, Chunyan Li
The biological effects of the transcription factor NF-E2-related factor 2 (Nrf2) in acute peripheral nervous system (PNS) injury have not been adequately elucidated. By analyzing the results of Nrf2 knockout and Nrf2 activation experiments, we found the following: (1) The antioxidant system was rapidly inactivated after acute PNS injury in a partly Nrf2-dependent manner, giving rise to a temporary state of oxidative stress, and then slowly and partially recovered following regeneration. (2) Nrf2 knockout promoted the reprogramming and proliferation of Schwann cells and inhibited myelination, as well as the redifferentiation of repair Schwann cells...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29625388/crocin-reverses-unilateral-renal-ischemia-reperfusion-injury-induced-augmentation-of-oxidative-stress-and-toll-like-receptor-4-activity
#4
Hadeer O Abou-Hany, Hoda Atef, Eman Said, Hassan A Elkashef, Hatem A Salem
Renal Ischemia (RI) usually develops as a secondary manifestation of hypertension, various cardiovascular disorders and renal transplantation. It exerts hypoxic oxidative stress to kidneys, together with stimulation of several immune-mediated inflammatory cascades. Such events eventually damage renal tubules and glomeruli, driving acute kidney injury (AKI) and ultimately, renal failure. Crocin; the main bioactive constituent of Crocus sativus extract has been reported to demonstrate numerous pharmacological merits...
March 27, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29604069/moderate-and-severe-hypoxia-elicit-divergent-effects-on-cardiovascular-function-and-physiological-rhythms
#5
Melissa A Allwood, Brittany A Edgett, Ashley L Eadie, Jason S Huber, Nadya Romanova, Philip J Millar, Keith R Brunt, Jeremy A Simpson
Hypoxia is both a consequence and cause of many acute and chronic diseases. Severe hypoxia causes hypertension with cardiovascular sequelae, however, the rare studies using moderate severities of hypoxia support that it can be beneficial, suggesting hypoxia may not always be detrimental. Comparisons between studies are difficult due to varied classifications of hypoxic severities, methods of delivery and use of anaesthetics. Thus, to investigate the long-term effects of moderate hypoxia on cardiovascular health, radio-telemetry was used to obtain in vivo physiological measurements in unanaesthetized mice during 24-hours of either moderate (FI O2  = 0...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29581653/effects-of-mechanical-bed-massage-on-exercise-induced-back-fatigue-in-athletes
#6
Houyong Zhong, Wichai Eungpinichpong, Xingze Wang, Uraiwon Chatchawan, Sawitri Wanpen, Orawan Buranruk
[Purpose] The study aimed to preliminarily investigate the effects of mechanical-bed massage on exercise-induced back fatigue in athletes. [Subjects and Methods] Twelve male college athletes, randomly allocated to experimental or control groups, were instructed to perform reverse sit-up for 8 sessions until they became fatigued. The experimental group received a 20-min mechanical-bed massage session, while the control group rested on a bed for the same period of time. Visual Analogue Scale (VAS) on perceived back muscle fatigue, back muscle endurance, and Heart Rate Variability (HRV) parameters including stress index (SI), HRV index, SDNN, RMSSD, pNN50, LF, HF, and LF/HF were analyzed...
March 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29554594/atorvastatin-dose-dependently-promotes-mouse-lung-repair-after-emphysema-induced-by-elastase
#7
Adriana Correa Melo, Isabella Cattani-Cavalieri, Marina Valente Barroso, Nicolas Quesnot, Lycia Brito Gitirana, Manuella Lanzetti, Samuel Santos Valença
Emphysema results in a proteinase - antiproteinase imbalance, inflammation and oxidative stress. Our objective was to investigate whether atorvastatin could repair mouse lungs after elastase-induced emphysema. Vehicle (50 μL) or porcine pancreatic elastase (PPE) was administered on day 1, 3, 5 and 7 at 0.6 U intranasally. Male mice were divided into a control group (sham), PPE 32d (sacrificed 24 h after 32 days), PPE 64d (sacrificed 24 h after 64 days), and atorvastatin 1, 5 and 20 mg treated from day 33 until day 64 and sacrificed 24 h later (A1 mg, A5 mg and A20 mg, respectively)...
March 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29510097/implementing-a-thoracic-enhanced-recovery-program-lessons-learned-in-the-first-year
#8
Linda W Martin, Bethany M Sarosiek, Meredith A Harrison, Traci Hedrick, James M Isbell, Alexander S Krupnick, Christine L Lau, J Hunter Mehaffey, Robert H Thiele, Dustin M Walters, Randal S Blank
BACKGROUND: To minimize the stress of operations, improve the patient experience, reduce variability, and optimize resource utilization, we implemented a thoracic enhanced recovery after surgery (ERAS) protocol and evaluated progress after 1 year. METHODS: Two protocols were developed: video-assisted thoracic surgery (ERAS-VATS) and thoracotomy (ERAS-T). Each incorporated preoperative patient education, carbohydrate loading, opioid-sparing analgesia, conservative fluid management, and early ambulation...
March 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29501008/effects-of-nutrient-restriction-and-arginine-treatment-on-oxidative-stress-in-the-ovarian-tissue-of-ewes-during-the-luteal-phase
#9
Yi-Xuan Guo, Hai-Tao Nie, Chen-Jie Xu, Guo-Min Zhang, Ling-Wei Sun, Ting-Ting Zhang, Zhen Wang, Xu Feng, Pei-Hua You, Feng Wang
The aim of this study was to determine whether nutrient restriction and arginine treatment affect energy metabolism changes and oxidative stress through the mitochondrial pathway in the ovarian tissue of ewes during the luteal phase. On days 6-15 of the estrous cycle, 24 multiparous Hu sheep (BW = 43.56 ± 1.53 kg) were randomly assigned to three groups: control group (CG; n = 6), restriction group (RG; n = 9), and l-arginine group (AG; n = 9) administered Arg treatment (or vehicle) three times per day...
June 2018: Theriogenology
https://www.readbyqxmd.com/read/29489843/dj-1-based-peptide-nd-13-promote-functional-recovery-in-mouse-model-of-focal-ischemic-injury
#10
Lior Molcho, Tali Ben-Zur, Yael Barhum, Daniel Offen
Stroke is a leading cause of death worldwide and inflicts serious long-term damage and disability. The vasoconstrictor Endothelin-1, presenting long-term neurological deficits associated with excitotoxicity and oxidative stress is being increasingly used to induce focal ischemic injury as a model of stroke. A DJ-1 based peptide named ND-13 was shown to protect against glutamate toxicity, neurotoxic insults and oxidative stress in various animal models. Here we focus on the benefits of treatment with ND-13 on the functional outcome of focal ischemic injury...
2018: PloS One
https://www.readbyqxmd.com/read/29474520/stability-indicating-rp-hplc-method-for-estimation-of-potential-impurities-in-ledipasvir-and-characterization-of-a-new-degradation-impurity
#11
R Siva Kumar, K V Sravan Kumar, L Kondareddy, K R Yogeshwara, Gangrade Manish, Jayachandran Jeenet, Kanyawar Nitesh
A new sensitive and stability indicating reverse phase high-performance liquid chromatography method has been developed for the quantitative determination of potential impurities of Ledipasvir, active pharmaceutical ingredient. Efficient chromatographic separation was achieved on waters × select column contains C18 stationary phase in gradient mode, quantitation at wavelength of 325 nm and mobile phase A is 50 mM ammonium formate pH 3.5 and mobile phase B is acetonitrile with flow rate 1.2 mL. The method was validated according to International Council for Hormonisation guideline, linearity studies has shown correlation coefficient value greater than 0...
February 21, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29472318/fork-protection-and-therapy-resistance-in-hereditary-breast-cancer
#12
Sharon B Cantor, Jennifer A Calvo
The BRCA-Fanconi anemia (FA) pathway preserves the genome and suppresses cancer and is a main determinant of chemotherapeutic efficacy. The hereditary breast cancer genes BRCA1 and BRCA2 function in DNA double-strand break repair mediating distinct steps of homologous recombination (HR). More recently, independent of DNA repair, functions in the replication stress response have come to light, providing insight as to how the BRCA-FA pathway also balances genome preservation with proliferation. The BRCA-FA proteins associate with the replisome and contribute to the efficiency and recovery of replication following perturbations that slow or arrest DNA replication...
February 22, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29454544/mapping-the-spatiotemporal-evolution-of-solute-transport-in-articular-cartilage-explants-reveals-how-cartilage-recovers-fluid-within-the-contact-area-during-sliding
#13
Brian T Graham, Axel C Moore, David L Burris, Christopher Price
The interstitial fluid within articular cartilage shields the matrix from mechanical stresses, reduces friction and wear, enables biochemical processes, and transports solutes into and out of the avascular extracellular matrix. The balanced competition between fluid exudation and recovery under load is thus critical to the mechanical and biological functions of the tissue. We recently discovered that sliding alone can induce rapid solute transport into buried cartilage contact areas via a phenomenon termed tribological rehydration...
April 11, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29450135/development-of-a-specific-index-to-detect-malnutrition-in-athletes-validity-in-weight-class-or-intermittent-fasted-athletes
#14
François D Desgorces, Christophe Moinard, Mounir Chennaoui, Jean-François Toussaint, Cyril Petibois, Philippe Noirez
Fasted or weight-category athletes manage their training under strict diet conditions that could impair the stress-recovery balance and result in acute or chronic fatigue. However, to date, no validated biomarker are available to quantify this phenomena. The aim of this study was to assess the validity of a specific index combining plasma albumin and weight change to detect nutrition-related risks of fatigue increase and under-performance in athletes experiencing particular nutritional conditions. An athlete's nutrition risk index (ANRI) equation, based on data from lightweight and heavyweight rowers, was developed using relationship between plasma albumin concentrations combined to weight changes with sport performance and overtraining scores and was tested by odds ratio for failure...
June 2017: Biochimie open
https://www.readbyqxmd.com/read/29345524/recovery-and-performance-in-sport-consensus-statement
#15
Michael Kellmann, Maurizio Bertollo, Laurent Bosquet, Michel Brink, Aaron Coutts, Rob Duffield, Daniel Erlacher, Shona Halson, Anne Hecksteden, Jahan Heidari, Romain Meeusen, Iñigo Mujika, Claudio Robazza, Sabrina Skorski, Ranel Venter, Jürgen Beckmann
The relationship between recovery and fatigue and its impact on performance has attracted the interest of sports science for many years. An adequate balance between stress (training and competition load, other life demands) and recovery is essential for athletes to achieve continuous high-level performance. Research has focused on the examination of physiological and psychological recovery strategies to compensate external and internal training and competition loads. A systematic monitoring of recovery and the subsequent implementation of recovery routines aims at maximizing performance and preventing negative developments such as underrecovery, non-functional overreaching, the overtraining syndrome, injuries, or illnesses...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29343237/subtypes-in-clinical-burnout-patients-enrolled-in-an-employee-rehabilitation-program-differences-in-burnout-profiles-depression-and-recovery-resources-stress-balance
#16
Kathrin Bauernhofer, Daniela Bassa, Markus Canazei, Paulino Jiménez, Manuela Paechter, Ilona Papousek, Andreas Fink, Elisabeth M Weiss
BACKGROUND: Burnout is generally perceived a unified disorder with homogeneous symptomatology across people (exhaustion, cynicism, and reduced professional efficacy). However, increasing evidence points to intra-individual patterns of burnout symptoms in non-clinical samples such as students, athletes, healthy, and burned-out employees. Different burnout subtypes might therefore exist. Yet, burnout subtypes based on burnout profiles have hardly been explored in clinical patients, and the samples investigated in previous studies were rather heterogeneous including patients with various physical, psychological, and social limitations, symptoms, and disabilities...
January 17, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29338020/autonomic-stress-reactivity-and-craving-in-individuals-with-problematic-internet-use
#17
Tania Moretta, Giulia Buodo
The link between autonomic stress reactivity and subjective urge/craving has been less systematically examined in behavioral addictions (i.e. problematic Internet use) than in substance use disorders. The present study investigated whether problematic Internet users (PU) show enhanced autonomic stress reactivity than non-PU, indexed by lower Heart Rate Variability (HRV) and higher Skin Conductance Level (SCL) reactivity during the Trier Social Stress Test (TSST), whether greater reactivity is related to stronger Internet craving, and whether problematic Internet usage is associated with some dysfunctional psychological features...
2018: PloS One
https://www.readbyqxmd.com/read/29247887/protective-role-of-exogenous-phytohormones-on-redox-status-in-pea-seedlings-under-copper-stress
#18
Marouane Ben Massoud, Lamia Sakouhi, Inès Karmous, Yao Zhu, Ezzedine El Ferjani, David Sheehan, Abdelilah Chaoui
The present work aims to provide insight on the role of phytohormone application in developing efficient practical defense strategies to improve plants tolerance under heavy metal contamination. For this purpose, pea (Pisum sativum L.) seeds were germinated in an aqueous solution of 200μM CuCl2 up to the 3rd day and then continued to germinate in the presence of distilled water (stress cessation) or were subjected to following combinations: Cu+1μM IAA and Cu+1μM GA3 for 3 additional days. The results showed that copper excess induced oxidative stress in germinating seeds, which resulted in changes of the redox state of glutathione and cysteine, and proteomics revealed Cu-induced modifications of thiols (SH) and carbonyls (CO) (indicators of protein oxidation)...
February 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#19
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29215751/proteomic-response-of-the-rat-liver-in-differential-swimming-modes
#20
Liang Chen, Yanhua Yang, Yiting Wang, Lipeng Qiu, Hengchuan Xia, Aiai Wang, Hailong Liu, Hongfei Shi, Keping Chen
Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between 2 swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to 2-dimensional electrophoresis (2DE)...
December 7, 2017: Clinical and Experimental Pharmacology & Physiology
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