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Recovery and adaptation

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https://www.readbyqxmd.com/read/28213914/novel-method-to-assess-intrinsic-heart-rate-recovery-in-ambulatory-ecg-recordings-tracks-cardioprotective-effects-of-chronic-autonomic-regulation-therapy-in-patients-enrolled-in-the-anthem-hf-study
#1
Gerrard M Carlson, Imad Libbus, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Postexercise heart rate recovery (HRR) is a powerful and independent predictor of mortality. Autonomic regulation therapy (ART) with chronic vagus nerve stimulation (VNS) has been shown to improve ventricular function in patients with chronic heart failure. However, the effect of ART on HRR in patients with heart failure remains unknown. METHODS: A new measure involving quantification of intrinsic HRR was developed for 24-hr ambulatory ECG (AECG) recordings based on spontaneous heart rate changes observed during daily activity in patients with symptomatic heart failure and reduced ejection fraction...
February 17, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28213240/sensitive-and-precise-monitoring-of-phosphatidylethanol-in-human-blood-as-a-biomarker-for-alcohol-intake-by-ultrasound-assisted-dispersive-liquid-liquid-microextraction-combined-with-liquid-chromatography-tandem-mass-spectrometry
#2
Siming Wang, Ruiyue Yang, Fusui Ji, Hongxia Li, Jun Dong, Wenxiang Chen
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted dispersive liquid-liquid microextraction was developed and validated for the measurements of PEth (16:0/18:1, 16:0/18:2, 16:0/16:0, and 18:1/18:1) in human blood. The influences of several variables for sample extraction and MS detection were carefully investigated...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28206802/exploring-the-post-deployment-reintegration-experiences-of-veterans-with-ptsd-and-their-significant-others
#3
I Magaly Freytes, Jennifer H LeLaurin, Susan L Zickmund, Rosana D Resende, Constance R Uphold
Veterans with family support have better functional recovery and reintegration outcomes. However, families' ability to support the veteran with PTSD's rehabilitation and reintegration oftentimes is hindered by interpersonal challenges. We report findings of a qualitative study that examined OEF/OIF veterans with PTSD/TBI and their significant others' (SOs') perceptions of family functioning. We conducted 24 in-depth interviews with 12 veteran/SO dyads using an adapted version of the Family Assessment Device Structured Interview...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28203643/establishing-elements-of-a-synthetic-biology-platform-for-vaccinia-virus-production-biobrick%C3%A2-design-serum-free-virus-production-and-microcarrier-based-cultivation-of-cv-1-cells
#4
Shuchang Liu, Ludmila Ruban, Yaohe Wang, Yuhong Zhou, Darren N Nesbeth
Vaccinia virus (VACV) is an established vector for vaccination and is beginning to prove effective as an oncolytic agent. Industrial production of VACV stands to benefit in future from advances made by synthetic biology in genome engineering and standardisation. The CV-1 cell line can be used for VACV propagation and has been used extensively with the CRISPR/Cas9 system for making precise edits of the VACV genome. Here we take first steps toward establishing a scalable synthetic biology platform for VACV production with CV-1 cells featuring standardised biological tools and serum free cell cultivation...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28202528/distinct-levels-of-radioresistance-in-lgr5-colonic-epithelial-stem-cells-versus-lgr5-small-intestinal-stem-cells
#5
Guoqiang Hua, Chu Wang, Yan Pan, Zhaoshi Zeng, Sang Gyu Lee, Maria Laura Martin, Adriana Haimovitz-Friedman, Zvi Fuks, Philip B Paty, Richard N Kolesnick
While small and large intestines possess seemingly similar Wnt-driven Leucine-rich repeat-containing G protein coupled receptor 5 (Lgr5)+ adult epithelial stem cells, we report here that the two organs exhibit distinct mechanisms of tissue response to ionizing radiation. Employing Lgr5-lacZ transgenic mice and Lgr5 in situ hybridization, we found colonic epithelial stem cells (CESC) markedly more radioresistant in vivo than small intestinal crypt base columnar stem cells (CBC) (D0 6.0±0.3 Gy vs. 1.3±0.1, respectively; p0...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28199867/plant-wide-modelling-of-phosphorus-transformations-in-wastewater-treatment-systems-impacts-of-control-and-operational-strategies
#6
K Solon, X Flores-Alsina, C Kazadi Mbamba, D Ikumi, E I P Volcke, C Vaneeckhaute, G Ekama, P A Vanrolleghem, D J Batstone, K V Gernaey, U Jeppsson
The objective of this paper is to report the effects that control/operational strategies may have on plant-wide phosphorus (P) transformations in wastewater treatment plants (WWTP). The development of a new set of biological (activated sludge, anaerobic digestion), physico-chemical (aqueous phase, precipitation, mass transfer) process models and model interfaces (between water and sludge line) were required to describe the required tri-phasic (gas, liquid, solid) compound transformations and the close interlinks between the P and the sulfur (S) and iron (Fe) cycles...
February 6, 2017: Water Research
https://www.readbyqxmd.com/read/28199759/bioinspired-design-of-a-robust-elastomer-with-adaptive-recovery-via-triazolinedione-click-chemistry
#7
Jing Huang, Lijie Zhang, Zhenghai Tang, Siwu Wu, Nanying Ning, Haibin Sun, Baochun Guo
It is a significant but challenging task to simultaneously reinforce and functionalize diene rubbers. Inspired by "sacrificial bonds", the authors engineer sacrificial hydrogen bonds formed by pendent urazole groups in crosslinked solution-polymerized styrene butadiene rubber (SSBR) via triazolinedione click chemistry. This post-crosslinking modification reveals the effects of the sacrificial bonds based on a consistent covalent network. The "cage effect" of the pre-crosslinked network facilitates the heterogeneous distribution of urazole groups, leading to the formation of hydrogen-bonded multiplets...
February 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28197888/stop-adding-insult-to-injury-identifying-and-managing-risk-factors-for-the-progression-of-acute-kidney-injury-in-children
#8
Wesley Hayes
Acute kidney injury (AKI) is common in children admitted to hospital. Whilst some recover normal kidney function following an acute kidney insult, a significant proportion experience long-term sequelae. The aim of this review is to summarize current understanding of the processes that can lead to sequelae following AKI. Kidney injury, repair, recovery and progression are described. Risk factors for progression are outlined, and potential strategies to stratify the risk of progression in children with AKI are discussed...
February 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28194315/screening-of-faba-bean-vicia-faba-l-accessions-to-acidity-and-aluminium-stresses
#9
Kiflemariam Y Belachew, Frederick L Stoddard
BACKGROUND: Faba bean is an important starch-based protein crop produced worldwide. Soil acidity and aluminium toxicity are major abiotic stresses affecting its production, so in regions where soil acidity is a problem, there is a gap between the potential and actual productivity of the crop. Hence, we set out to evaluate acidity and aluminium tolerance in a range of faba bean germplasm using solution culture and pot experiments. METHODS: A set of 30 accessions was collected from regions where acidity and aluminium are or are not problems...
2017: PeerJ
https://www.readbyqxmd.com/read/28192618/intra-annual-plasticity-of-growth-mediates-drought-resilience-over-multiple-years-in-tropical-seedling-communities
#10
Michael J O'Brien, Robert Ong, Glen Reynolds
Precipitation patterns are changing across the globe causing more severe and frequent drought for many forest ecosystems. Although research has focused on the resistance of tree populations and communities to these novel precipitation regimes, resilience of forests is also contingent on recovery following drought, which remains poorly understood, especially in aseasonal tropical forests. We used rainfall exclusion shelters to manipulate the inter-annual frequency of drought for diverse seedling communities in a tropical forest and assessed resistance, recovery and resilience of seedling growth and mortality relative to everwet conditions...
February 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28190338/towards-streamlined-identification-of-dioxin-like-compounds-in-environmental-samples-through-integration-of-suspension-bioassay
#11
Hongxia Xiao, Markus Brinkmann, Beat Thalmann, Andreas Schiwy, Sigrid Große Brinkhaus, Christine Achten, Kathrin Eichbaum, Carolin Gembé, Thomas Benjamin Seiler, Henner Hollert
Effect-directed analysis (EDA) is a powerful strategy to identify biologically active compounds in environmental samples. However, in current EDA studies, fractionation and handling procedures are laborious, consist of multiple evaporation steps, and thus bear the risk of contamination and decreased recoveries of the target compounds. The low resulting throughput has been one of the major bottlenecks of EDA. Here, we propose a high-throughput EDA (HT-EDA) work-flow combining reversed phase high-performance liquid chromatography (HPLC) fractionation of samples into 96-well microplates, followed by toxicity assessment in the micro-EROD bioassay with the wild-type rat hepatoma H4IIE cells, and chemical analysis of bioactive fractions...
February 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28188782/lipid-and-carotenoid-cooperation-driven-adaptation-to-light-and-temperature-stress-in-synechocystis-sp-pcc6803
#12
Tomas Zakar, Eva Herman, Sindhujaa Vajravel, Laszlo Kovacs, Jana Knoppová, Josef Komenda, Ildiko Domonkos, Mihaly Kis, Zoltan Gombos, Hajnalka Laczko-Dobos
Polyunsaturated lipids are important components of photosynthetic membranes. Xanthophylls are the main photoprotective agents, can assist in protection against light stress, and are crucial in the recovery from photoinhibition. We generated the xanthophyll- and polyunsaturated lipid-deficient ROAD mutant of Synechocystis sp. PCC6803 (Synechocystis) in order to study the little-known cooperative effects of lipids and carotenoids (Cars). Electron microscopic investigations confirmed that in the absence of xanthophylls the S-layer of the cellular envelope is missing...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28188207/use-of-endophytic-and-rhizosphere-bacteria-to-improve-phytoremediation-of-arsenic-contaminated-industrial-soils-by-autochthonous-betula-celtiberica
#13
Victoria Mesa, Alejandro Navazas, Ricardo González-Gil, Aida González, Nele Weyens, Béatrice Lauga, Jose Luis R Gallego, Jesús Sánchez, Ana Isabel Peláez
The aim of the study was to investigate the potential of indigenous arsenic-tolerant bacteria to enhance arsenic phytoremediation by autochthonous pseudometallophyte Betula celtiberica The first goal was to perform an initial analysis of the entire rhizosphere and endophytic bacterial communities of the above-named accumulator plant, including the cultivable bacterial species. B. celtiberica's microbiome was dominated by taxa related to Flavobacteriales, Burkholderiales, and Pseudomonadales, specially the Pseudomonas and Flavobacterium genera...
February 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28187702/adaptation-response-of-pseudomonas-fragi-on-refrigerated-solid-matrix-to-a-moderate-electric-field
#14
Wenbo Chen, Honghai Hu, Chunjiang Zhang, Feng Huang, Dequan Zhang, Hong Zhang
BACKGROUND: Moderate electric field (MEF) technology is a promising food preservation strategy since it relies on physical properties-rather than chemical additives-to preserve solid cellular foods during storage. However, the effectiveness of long-term MEF exposure on the psychrotrophic microorganisms responsible for the food spoilage at cool temperatures remains unclear. RESULTS: The spoilage-associated psychrotroph Pseudomonas fragi MC16 was obtained from pork samples stored at 7 °C...
February 10, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28185801/lived-experience-of-having-a-child-with-stroke-a%C3%A2-qualitative-study
#15
Syrine Soufi, Stéphane Chabrier, Laurent Bertoletti, Silvy Laporte, Stéphane Darteyre
OBJECTIVE: To assess the lived experience of parents whose child has suffered a stroke. METHODS: A qualitative study model was chosen, comprising in-depth interviews with parents separately or altogether. A semi-structured interview guide was used. Interviews were audio-recorded, transcribed verbatim and analysed using constant comparison and content analysis. Participant checking was performed. Thirteen families of children aged 1 month to 17 years, having suffered ischaemic or haemorrhagic arterial stroke within one to five years, were recruited...
January 25, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28182105/neuroplastic-correlates-in-the-mpfc-underlying-the-impairment-of-stress-coping-ability-and-cognitive-flexibility-in-adult-rats-exposed-to-chronic-mild-stress-during-adolescence
#16
Yu Zhang, Feng Shao, Qiong Wang, Xi Xie, Weiwen Wang
Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28-41) CMS induced transient alterations in anhedonia that did not persist into adulthood after a 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors in the forced swimming test and a greater number of trials to reach criterion in the set-shifting task, suggesting the impaired ability to cope with stressors and the cognitive flexibility that allows adaptation to dynamic environments during adulthood...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28177740/modified-sprint-interval-training-protocols-part-i-physiological-responses
#17
Hashim Islam, Logan K Townsend, Tom J Hazell
Adaptations to sprint interval training (SIT) are observed with brief (≤15s) work bouts highlighting peak power generation as an important metabolic stimulus. This study examined the effects of manipulating SIT work bout and recovery period duration on energy expenditure (EE) during and post-exercise, as well as post-exercise fat oxidation rates. Nine active males completed a resting control session (CTRL) and three SIT sessions in randomized order: 1) 30:240 (4 x 30 s bouts, 240 s recovery); 2) 15:120 (8 x 15 s bouts, 120 s recovery); 3) 5:40 (24 x 5 s bouts, 40 s recovery)...
December 8, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177701/acute-upregulation-of-pgc-1%C3%AE-mrna-correlates-with-training-induced-increases-in-sdh-activity-in-human-skeletal-muscle
#18
Jacob T Bonafiglia, Brittany A Edgett, Brittany L Baechler, Matthew William Nelms, Craig A Simpson, Joe Quadrilatero, Brendon J Gurd
The purpose of the present study was to determine if acute responses in pgc-1α, vegfa, sdha, and gpd1/2 mRNA expression predict their associated chronic skeletal muscle molecular (SDH/GPD activity and substrate storage) and morphological (fibre type composition and capillary density) adaptations following training. Skeletal muscle biopsies were collected from fourteen recreationally active men (age: 22.0 ± 2.4 years) before (PRE) and 3 hours after (3HR) the completion of an acute bout of SIT (eight, 20-second intervals at ~170% VO2peak work rate separated by 10 seconds of recovery)...
February 2, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28167230/adaptation-to-a-blood-pressure-telemetry-system-revealed-by-measures-of-activity-agility-and-operant-learning-in-mice
#19
Anfisa Popova, Darya Tsvirkun, Oleg Dolgov, Konstantin Anokhin, Jeffrey Alberts, Evgeniia Lagereva, Marc-Antoine Custaud, Guillemette Gauquelin-Koch, Olga Vinogradova, Alexander Andreev-Andrievskiy
INTRODUCTION: Implantable telemetry enables continuous monitoring of physiological functions in freely moving animals and can greatly complement pharmacological research. Despite its miniaturization, a sensor/transmitter constitutes 5% or more of a mouse's bodyweight. The aim of the present study was to evaluate whether factors related to the presence of a probe/transmitter influence the ambulatory activity, strength, agility, or operant, motivated behaviors of this small rodent. METHODS: Adult male mice (C57BL/6N, 22-25g, 9-10weeks; implanted n=26, intact n=45) were evaluated during week-long tests, conducted three and eight weeks after surgical implantation of the PA-C10 blood pressure probe...
February 3, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28165342/epicardial-yap-taz-orchestrate-an-immunosuppressive-response-following-myocardial-infarction
#20
Vimal Ramjee, Deqiang Li, Lauren J Manderfield, Feiyan Liu, Kurt A Engleka, Haig Aghajanian, Christopher B Rodell, Wen Lu, Vivienne Ho, Tao Wang, Li Li, Anamika Singh, Dasan M Cibi, Jason A Burdick, Manvendra K Singh, Rajan Jain, Jonathan A Epstein
Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling is a multifaceted process that includes activation of fibroblasts and a complex immune response. T-regulatory cells (Tregs), a subset of CD4+ T cells, have been shown to suppress the innate and adaptive immune response and limit deleterious remodeling following myocardial injury. However, the mechanisms by which injured myocardium recruits suppressive immune cells remain largely unknown...
February 6, 2017: Journal of Clinical Investigation
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