Riccardo Dore, Sarah Christine Sentis, Kornelia Johann, Nuria Lopez-Alcantara, Julia Resch, Akila Chandrasekar, Helge Müller-Fielitz, Lars Christian Moeller, Dagmar Fuehrer, Markus Schwaninger, Benedikt Obermayer, Robert Opitz, Jens Mittag
Background: Thyroid hormones regulate cardiac functions mainly through direct actions in the heart and by binding to the thyroid hormone receptor (TR) isoforms α1 and β. While the role of the most abundantly expressed isoform, TRα1, is widely studied and well characterized, the role of TRβ in regulating heart functions is still poorly understood, primarily due to the accompanying elevation of circulating thyroid hormone in TRβ knockout mice (TRβ-KO). However, their hyperthyroidism is ameliorated at thermoneutrality, which allows studying the role of TRβ without this confounding factor...
April 8, 2024: Thyroid: Official Journal of the American Thyroid Association