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ischaemic heart diseases

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https://www.readbyqxmd.com/read/29136331/risk-factor-management-in-a-contemporary-australian-population-at-increased-cardiovascular-disease-risk
#1
D J Campbell, J M Coller, F F Gong, M McGrady, D L Prior, U Boffa, L Shiel, D Liew, R Wolfe, A J Owen, H Krum, C M Reid
BACKGROUND: Effective management of cardiovascular and chronic kidney disease risk factors offers longer, healthier lives and savings in health care. We examined risk factor management in participants of the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) study, a self-selected population at increased cardiovascular disease risk recruited from members of a health insurance fund in Melbourne and Shepparton, Australia. METHODS: Inclusion criteria were age ≥60 years with one or more of self-reported ischaemic or other heart disease, irregular or rapid heart rhythm, cerebrovascular disease, renal impairment, or treatment for hypertension or diabetes for ≥2 years...
November 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29135296/-ischaemic-heart-disease-in-cancer-patients-questions-and-problems
#2
Petra Gulácsi-Bárdos, Miklós Szokol, Mária Lódi, Dániel Czuriga, István Czuriga, István Édes, András Nagy, Balázs Sármán
Cardiovascular and oncologic diseases are the causes of more than 50 percent of mortality in Europe. In 2015 oncologic and cardiovascular mortality reached 70 percent in Hungary. Patients who receive anticancer therapies are at a 2- to 7-fold greater long-term risk of acute coronary syndrome; also concomittant oncologic diseases further increase the mortality of myocardial infarction. Unfortunately there is not enough data concerning cardiovascular treatment of oncologic patients because they were excluded from most of the studies and registries...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29120327/capillary-pericytes-mediate-coronary-no-reflow-after-myocardial-ischaemia
#3
Fergus M O'Farrell, Svetlana Mastitskaya, Matthew Hammond-Haley, Felipe Freitas, Wen Rui Wah, David Attwell
After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, followed by reperfusion, blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region. Capillary blockages colocalised strongly with pericytes, where capillary diameter was reduced by 37%...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29114078/patient-selection-for-high-sensitivity-cardiac-troponin-testing-and-diagnosis-of-myocardial-infarction-prospective-cohort-study
#4
MULTICENTER STUDY
Anoop S V Shah, Yader Sandoval, Ala Noaman, Anne Sexter, Amar Vaswani, Stephen W Smith, Mathew Gibbins, Megan Griffiths, Andrew R Chapman, Fiona E Strachan, Atul Anand, Martin A Denvir, Philip D Adamson, Michelle S D'Souza, Alasdair J Gray, David A McAllister, David E Newby, Fred S Apple, Nicholas L Mills
Objective To evaluate how selection of patients for high sensitivity cardiac troponin testing affects the diagnosis of myocardial infarction across different healthcare settings.Design Prospective study of three independent consecutive patient populations presenting to emergency departments.Setting Secondary and tertiary care hospitals in the United Kingdom and United States.Participants High sensitivity cardiac troponin I concentrations were measured in 8500 consecutive patients presenting to emergency departments: unselected patients in the UK (n=1054) and two selected populations of patients in whom troponin testing was requested by the attending clinician in the UK (n=5815) and the US (n=1631)...
November 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29106545/extracellular-vesicles-in-diagnostics-and-therapy-of-the-ischaemic-heart-position-paper-from-the-working-group-on-cellular-biology-of-the-heart-of-the-european-society-of-cardiology
#5
Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal Marthe Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Cinzia Perrino, Fabrice Prunier, Susmita Sahoo, Ray Michel Schiffelers, Rainer Schulz, Linda Wilhelmina Van Laake, Kirsti Ytrehus, Péter Ferdinandy
Extracellular vesicles (EVs) - particularly exosomes and microvesicles - are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction...
November 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29101264/increased-coronary-heart-disease-and-stroke-hospitalisations-from-ambient-temperatures-in-ontario
#6
Li Bai, Qiongsi Li, Jun Wang, Eric Lavigne, Antonio Gasparrini, Ray Copes, Abderrahmane Yagouti, Richard T Burnett, Mark S Goldberg, Sabit Cakmak, Hong Chen
OBJECTIVE: To assess the associations between ambient temperatures and hospitalisations for coronary heart disease (CHD) and stroke. METHODS: Our study comprised all residents living in Ontario, Canada, 1996-2013. For each of 14 health regions, we fitted a distributed lag non-linear model to estimate the cold and heat effects on hospitalisations from CHD, acute myocardial infarction (AMI), stroke and ischaemic stroke, respectively. These effects were pooled using a multivariate meta-analysis...
November 3, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29101149/quantifying-the-role-of-modifiable-risk-factors-in-the-differences-in-cardiovascular-disease-mortality-rates-between-metropolitan-and-rural-populations-in-australia-a-macrosimulation-modelling-study
#7
Laura Alston, Karen Louise Peterson, Jane P Jacobs, Steven Allender, Melanie Nichols
OBJECTIVES: The study aimed (1) to quantify differences in modifiable risk factors between urban and rural populations, and (2) to determine the number of rural cardiovascular disease (CVD) and ischaemic heart disease (IHD) deaths that could be averted or delayed if risk factor levels in rural areas were equivalent to metropolitan areas. SETTING: National population estimates, risk factor prevalence, CVD and IHD deaths data were analysed by rurality using a macrosimulation Preventable Risk Integrated Model for chronic disease risk...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29101147/protocol-for-the-happy-hearts-study-cardiovascular-screening-for-the-early-detection-of-future-adverse-cardiovascular-outcomes-in-middle-aged-and-older-women-a-prospective-observational-cohort-study
#8
Kevin F Boreskie, D Scott Kehler, Eduardo C Costa, Pedro C Cortez, Ivan Berkowitz, Naomi C Hamm, Teri L Moffatt, Andrew N Stammers, Dustin E Kimber, Brett M Hiebert, David E Kent, Denise E Cornish, Heather Blewett, Thang Nguyen, Rakesh C Arora, Shaelyn M Strachan, Brittany N Semenchuk, Jacqueline L Hay, Jay N Cohn, Todd A Duhamel
INTRODUCTION: Efforts to identify individuals at a higher risk for adverse cardiovascular outcomes focus on traditional risk factors, such as age, sex, smoking status, blood pressure and and cholesterol; however, this approach does not directly assess cardiovascular function and may underestimate the risk of experiencing adverse cardiovascular outcomes in women. This prospective, observational cohort study will examine the ability of the Heart Attack Prevention Program for You (HAPPY) Hearts screening protocol, a series of non-invasive procedures to identify middle-aged and older women who are at an elevated risk for experiencing an adverse cardiovascular event in the 5-year period after screening...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29095881/a-core-outcome-set-for-adult-cardiac-surgery-trials-a-consensus-study
#9
Carina Benstoem, Ajay Moza, Patrick Meybohm, Christian Stoppe, Rüdiger Autschbach, Declan Devane, Andreas Goetzenich
BACKGROUND: Invasive off- or on-pump cardiac surgery (elective and emergency procedures, excluding transplants are routinely performed to treat complications of ischaemic heart disease. Randomised controlled trials (RCT) evaluate the effectiveness of treatments in the setting of cardiac surgery. However, the impact of RCTs is weakened by heterogeneity in outcome measuring and reporting, which hinders comparison across trials. Core outcome sets (COS, a set of outcomes that should be measured and reported, as a minimum, in clinical trials for a specific clinical field) help reduce this problem...
2017: PloS One
https://www.readbyqxmd.com/read/29084175/spatiotemporal-changes-in-fine-particulate-matter-pollution-and-the-associated-mortality-burden-in-china-between-2015-and-2016
#10
Luwei Feng, Bo Ye, Huan Feng, Fu Ren, Shichun Huang, Xiaotong Zhang, Yunquan Zhang, Qingyun Du, Lu Ma
In recent years, research on the spatiotemporal distribution and health effects of fine particulate matter (PM2.5) has been conducted in China. However, the limitations of different research scopes and methods have led to low comparability between regions regarding the mortality burden of PM2.5. A kriging model was used to simulate the distribution of PM2.5 in 2015 and 2016. Relative risk (RR) at a specified PM2.5 exposure concentration was estimated with an integrated exposure-response (IER) model for different causes of mortality: lung cancer (LC), ischaemic heart disease (IHD), cerebrovascular disease (stroke) and chronic obstructive pulmonary disease (COPD)...
October 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29084020/use-of-implantable-cardioverter-defibrillator-in-nonischaemic-cardiomyopathy-a-u-turn
#11
Fiorenzo Gaita, Davide Castagno, Matteo Anselmino
: Use of implantable cardioverter defibrillator (ICD) in primary prevention has been shown to reduce the risk of death among patients with severe left ventricular systolic dysfunction (LVSD) due to ischaemic cardiomyopathy. However, among patients with heart failure and severe LVSD who do not have coronary artery disease, the evidence of ICD benefit is less robust. As a matter of fact, data supporting the use of ICD in such patients are limited to a few randomized controlled clinical trials that included a small number of patients, subgroup analysis of larger trials or meta-analysis...
October 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29082834/kidney-function-is-associated-with-short-term-mid-term-and-long-term-clinical-outcome-after-coronary-angiography-and-intervention
#12
Andrie G Panayiotou, Jonas Spaak, Majid Kalani
BACKGROUND: Patients with kidney dysfunction are at risk of developing ischaemic heart disease. We investigated the association between eGFR and early-, mid- and long-term clinical outcome in patients undergoing coronary angiography and intervention. METHODS: Retrospective study on 4968 patients with complete data on eGFR, 65% male and aged 32-80 years, admitted to Danderyd University Hospital, Stockholm, Sweden for coronary angiography and intervention from 2006 to 2008...
October 30, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29072438/economic-burden-of-smoking-in-iran-a-prevalence-based-annual-cost-approach
#13
Satar Rezaei, Behzad Karami Matin, Mohammad Hajizadeh, Mohammad Bazyar, Ali Akbari Sari
Objectives: The burden of smoking on the health system and society is significant. The current study aimed to estimate the annual direct and indirect costs of smoking in Iran for the year 2014. Methods: A prevalence-based diseasespecific approach was used to determine costs associated with the three most common smoking-related diseases: lung cancer (LC), chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD). Data on healthcare utilization were obtained from an original survey, hospital records and questionnaires...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071437/effect-of-long-term-remote-ischemic-conditioning-in-patients-with-chronic-ischemic-heart-failure
#14
Kasper Pryds, Roni Ranghøj Nielsen, Anders Jorsal, Mona Sahlholdt Hansen, Steffen Ringgaard, Jens Refsgaard, Won Yong Kim, Annemette Krintel Petersen, Hans Erik Bøtker, Michael Rahbek Schmidt
Remote ischemic conditioning (RIC) protects against acute ischemia-reperfusion injury and may also have beneficial effects in patients with stable cardiovascular disease. We investigated the effect of long-term RIC treatment in patients with chronic ischaemic heart failure (CIHF). In a parallel group study, 22 patients with compensated CIHF and 21 matched control subjects without heart failure or ischemic heart disease were evaluated by cardiac magnetic resonance imaging, cardiopulmonary exercise testing, skeletal muscle function testing, blood pressure measurement and blood sampling before and after 28 ± 4 days of once daily RIC treatment...
October 25, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29069478/cannulation-strategy-for-centrifugal-flow-ventricular-assist-device-implantation-late-after-arterial-switch-operation
#15
Ziv Beckerman, Hari Tunuguntla, Charles D Fraser, Iki Adachi
The field of paediatric ventricular assist device (VAD) support is growing rapidly. Among paediatric patients, those with complex congenital heart disease represent a challenging population for VAD support. This report describes a patient with a remote history of an arterial switch operation for d -transposition of the great arteries who developed ischaemic cardiomyopathy necessitating centrifugal-flow VAD support as a bridge to cardiac transplantation. Because of the unique anatomy and the complicated vascular situation, implantation of the centrifugal-flow VAD and subsequent explantation for cardiac transplantation required modifications to the standard surgical approach...
October 24, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29069369/high-resolution-three-dimensional-late-gadolinium-enhanced-cardiac-magnetic-resonance-imaging-to-identify-the-underlying-substrate-of-ventricular-arrhythmia
#16
Alexia Hennig, Marjorie Salel, Frederic Sacher, Claudia Camaioni, Soumaya Sridi, Arnaud Denis, Michel Montaudon, François Laurent, Pierre Jais, Hubert Cochet
Aims: Cardiac magnetic resonance (CMR) is recommended as a second-line method to diagnose ventricular arrhythmia (VA) substrate. We assessed the diagnostic yield of CMR including high-resolution late gadolinium-enhanced (LGE) imaging. Methods and results: Consecutive patients with sustained ventricular tachycardia (VT), non-sustained VT (NSVT), or ventricular fibrillation/aborted sudden death (VF/SCD) underwent a non-CMR diagnostic workup according to current guidelines, and CMR including LGE imaging with both a conventional breath-held and a free-breathing method enabling higher spatial resolution (HR-LGE)...
October 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29066842/screening-and-identification-of-critical-transcription-factors-involved-in-the-protection-of-cardiomyocytes-against-hydrogen-peroxide-induced-damage-by-yixin-shu
#17
Jingjing Zhang, Ya Geng, Feifei Guo, Fangbo Zhang, Mingwei Liu, Lei Song, Yuexiang Ma, Defeng Li, Yi Zhang, Haiyu Xu, Hongjun Yang
Oxidative stress initiates harmful cellular responses, such as DNA damage and protein denaturation, triggering a series of cardiovascular disorders. Systematic investigations of the transcription factors (TFs) involved in oxidative stress can help reveal the underlying molecular mechanisms and facilitate the discovery of effective therapeutic targets in related diseases. In this study, an integrated strategy which integrated RNA-seq-based transcriptomics techniques and a newly developed concatenated tandem array of consensus TF response elements (catTFREs)-based proteomics approach and then combined with a network pharmacology analysis, was developed and this integrated strategy was used to investigate critical TFs in the protection of Yixin-shu (YXS), a standardized medical product used for ischaemic heart disease, against hydrogen peroxide (H2O2)-induced damage in cardiomyocytes...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056992/association-of-polymorphisms-of-platelet-receptors-gpia-807c-t-gpvi-13254t-c-and-p2y12-34c-t-and-h1-h2-haplotype-with-increased-risk-of-periprocedural-bleeding-in-patients-undergoing-coronary-angiography-percutaneous-coronary-intervention
#18
Magdalena Sionova, Peter Blasko, Stepan Jirous, David Vindis, Richard Rokyta, Zuzana Motovska
INTRODUCTION: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-risk patients. AIM: To analyse the association between single nucleotide polymorphisms (SNPs) of crucial haemostatic platelet receptors (GPIa, GPVI, P2Y12) and the risk of periprocedural bleeding complications related to CAG/PCI...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29053020/cardiovascular-outcomes-for-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-in-the-health-improvement-network-thin-in-the-uk
#19
Lucía Cea Soriano, F Gerry R Fowkes, Saga Johansson, Alaster M Allum, Luis A García Rodriguez
Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantified risk factors for cardiovascular outcomes in patients with peripheral artery disease. Methods Among patients in The Health Improvement Network (THIN) aged 50-89 years in 2000-2010, a symptomatic peripheral artery disease cohort ( n = 28,484) and a matched comparison cohort without peripheral artery disease ( n = 113,940) were identified using Read codes...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29051568/synchrotron-radiation-circular-dichroism-spectroscopy-reveals-structural-divergences-in-hdl-bound-apoa-i-variants
#20
Rita Del Giudice, Oktawia Nilsson, Joan Domingo-Espín, Jens O Lagerstedt
Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) provides cardiovascular protection. Synchrotron radiation circular dichroism (SRCD) spectroscopy was used to analyze the dynamic solution structure of the apoA-I protein in the apo- and HDL-states and the protein structure conversion in HDL formation. Wild-type apoA-I protein was compared to human variants that either are protective (R173C, Milano) or lead to increased risk for ischaemic heart disease (A164S). Comparable secondary structure distributions in the HDL particles, including significant levels of beta strand/turn, were observed...
October 19, 2017: Scientific Reports
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