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https://www.readbyqxmd.com/read/28639369/a-network-analysis-to-compare-biomarker-profiles-in-patients-with-and-without-diabetes-mellitus-in-acute-heart-failure
#1
Abhinav Sharma, Biniyam G Demissei, Jasper Tromp, Hans L Hillege, John G Cleland, Christopher M O'Connor, Marco Metra, Piotr Ponikowski, John R Teerlink, Beth A Davison, Michael M Givertz, Daniel M Bloomfield, Howard Dittrich, Dirk J van Veldhuisen, Gad Cotter, Justin A Ezekowitz, Mohsin A F Khan, Adriaan A Voors
AIMS: It is unclear whether distinct pathophysiological processes are present among patients with acute heart failure (AHF), with and without diabetes. Network analysis of biomarkers may identify correlative associations that reflect different pathophysiological pathways. METHODS AND RESULTS: We analysed a panel of 48 circulating biomarkers measured within 24 h of admission for AHF in a subset of patients enrolled in the PROTECT trial. In patients with and without diabetes, we performed a network analysis to identify correlations between measured biomarkers...
June 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28636084/co-morbidities-and-bleeding-in-elderly-patients-with-haemophilia-a-survey-of-the-german-austrian-and-swiss-society-of-thrombosis-and-haemostasis-research-gth
#2
W Miesbach, S-E Reitter-Pfoertner, R Klamroth, F Langer, H-H Wolf, A Tiede, B Siegmund, U Scholz, P R Müller, H Eichler, I Pabinger
BACKGROUND: Nowadays patients with haemophilia survive longer due to improvements in haemophilia care. It has been hypothesized that the bleeding type and frequency may vary with age and are influenced by co-morbidities and co-medication in elderly patients. OBJECTIVES: To investigate a large group of patients older than 60 years of age with haemophilia concerning haemophilia treatment, bleeding pattern changes, co-morbidities, co-medication, bleeding sites and patient mortality...
June 21, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28630772/severe-rhabdomyolysis-due-to-presumed-drug-interactions-between-atorvastatin-with-amlodipine-and-ticagrelor
#3
Iouri Banakh, Kavi Haji, Ross Kung, Sachin Gupta, Ravindranath Tiruvoipati
Atorvastatin and ticagrelor combination is a widely accepted therapy for secondary prevention of ischaemic heart disease. However, rhabdomyolysis is a well-known rare side effect of statins which should be considered when treatments are combined with cytochrome P450 3A4 enzyme inhibitors. We report a case of atorvastatin and ticagrelor associated severe rhabdomyolysis that progressed to multiorgan failure requiring renal replacement therapy, inotropes, intubation, and mechanical ventilation. Despite withdrawal of the precipitating cause and the supportive measures including renal replacement therapy, creatinine kinase increased due to ongoing rhabdomyolysis rapidly progressing to upper and lower limbs weakness...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28630219/a-rare-case-of-sigmoid-colon-perforation-with-subsequent-psoas-abscess-collection-with-extensive-involvement-of-the-sartorius-muscle
#4
Ali Wadood, Abdulrahman Odeh, Khizer Rana, Shafquat Zaman
A middle-aged man was admitted with worsening hip pain, fevers and reduced mobility. These symptoms were preceded by a mechanical fall but despite regular analgesia, symptoms did not resolve. His prior medical history included ischaemic heart disease, hypertension and hypercholesterolaemia. A trauma and orthopaedic review revealed a painful left hip with reduced range of motion. In addition, some mild tenderness in the left iliac fossa was noted. Blood tests revealed markedly raised inflammatory markers. Plain radiographs and ultrasound were normal...
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28627763/suspected-methadone-toxicity-from-hospital-to-autopsy-bed
#5
Jaber Gharehdaghi, Asieh Takalloo-Bakhtiari, Hossein Hassanian-Moghaddam, Nasim Zamani, Mohammad-Javad Hedayatshode
High mortality rates have been reported for methadone in both adults and children. We aimed to determine the pattern of toxicity, possible underlying diseases and treatment challenges in patients referred to our center with early diagnosis of methadone toxicity and who later died. Medical files of all methadone-poisoned patients who had been admitted to a referral center of toxicology between March 2011 and March 2016, died during the hospital stay and sent for autopsy to Legal Medicine Organization were retrospectively evaluated...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28626956/markedly-increased-incidence-of-critical-illness-in-adults-with-type-1-diabetes
#6
R A Marrie, E A C Sellers, H Chen, R Fransoo, C N Bernstein, C A Hitchon, C A Peschken, A Garland
AIMS: To compare the incidence of and mortality after intensive care unit admission in adults with paediatric-onset Type 1 diabetes vs the general population. METHODS: Using population-based administrative data from Manitoba, Canada, we identified 814 cases of paediatric-onset Type 1 diabetes, and 3579 general population controls matched on age, sex and region of residence. We estimated the incidence of intensive care unit admission in adulthood, and compared the findings between populations using incidence rate ratios and multivariable Cox proportional hazards regression, adjusting for age, sex, comorbidity and socio-economic status...
June 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28618916/who-needs-secondary-prevention
#7
Ines Frederix, Paul Dendale, Jean-Paul Schmid
Secondary prevention for ischaemic heart disease can be defined as a comprehensive set of measures, aiming to reduce the recurrence of cardiovascular disease and to improve long-term prognosis. Despite its proven efficacy, uptake and adherence rates remain poor. This paper summarises the available European recommendations for secondary prevention in varying ischaemic heart disease populations, including those patients with specific co-morbidities. The scientific evidence supporting these recommendations is provided...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28618914/role-of-the-polypill-for-secondary-prevention-in-ischaemic-heart-disease
#8
José M Castellano, Valentín Fuster, Catriona Jennings, Eva Prescott, Héctor Bueno
In 2011, for the first time in the history of humankind, non-communicable diseases became the leading cause of death worldwide. This change in trend is obviously multifactorial and very complex, as it is the paradoxical result of social, economic and health system growth worldwide. Vaccination and infectious diseases control, changing dietary habits worldwide, sedentary behaviour, globalisation, industrialisation (resulting in a shift from manual to sedentary labour), tobacco and sugary beverage surges in low- and middle-income countries and rapid urbanisation have all played a role in this epidemic transition...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28618904/antiplatelet-and-antithrombotic-treatment-for-secondary-prevention-in-ischaemic-heart-disease
#9
Maddalena Lettino, Sergio Leonardi, Elia De Maria, Sigrun Halvorsen
Platelets play a key role in the pathogenesis of acute coronary syndromes and this is why antiplatelet drugs are essential, both in the acute phase and in the long-term follow-up in preventing recurrent myocardial infarction, stroke and cardiovascular death. Aspirin is the most used agent and still remains the first choice drug for lifelong administration in secondary prevention after myocardial infarction. Dual antiplatelet therapy, targeting more than one pathway of platelet activation, has significantly improved the outcome of patients with acute coronary syndromes despite an increased risk of bleeding complications...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28617184/patient-perceptions-of-experience-with-cardiac-rehabilitation-after-isolated-heart-valve-surgery
#10
Tina B Hansen, Selina K Berg, Kirstine L Sibilitz, Ann D Zwisler, Tone M Norekvål, Anne Lee, Niels Buus
BACKGROUND: Little evidence exists on whether cardiac rehabilitation is effective for patients after heart valve surgery. Yet, accepted recommendations for patients with ischaemic heart disease continue to support it. To date, no studies have determined what heart valve surgery patients prefer in a cardiac rehabilitation programme, and none have analysed their experiences with it. AIMS: The purpose of this qualitative analysis was to gain insight into patients' experiences in cardiac rehabilitation, the CopenHeartVR trial...
June 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28608759/challenges-in-secondary-prevention-after-acute-myocardial-infarction-a-call-for-action
#11
Massimo F Piepoli, Ugo Corrà, Paul Dendale, Ines Frederix, Eva Prescott, Jean Paul Schmid, Margaret Cupples, Christi Deaton, Patrick Doherty, Pantaleo Giannuzzi, Ian Graham, Tina Birgitte Hansen, Catriona Jennings, Ulf Landmesser, Pedro Marques-Vidal, Christiaan Vrints, David Walker, Hector Bueno, Donna Fitzsimons, Antonio Pelliccia
Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and approximately 50% of major coronary events occur in those with a previous hospital discharge diagnosis of ischaemic heart disease. The people behind these numbers spur this call for action. Prevention after myocardial infarction is crucial to reduce risk and suffering...
June 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28607164/cochrane-corner-stem-cell-therapy-for-chronic-ischaemic-heart-disease-and-congestive-heart-failure
#12
EDITORIAL
Sheila A Fisher, Carolyn Doree, Anthony Mathur, David P Taggart, Enca Martin-Rendon
No abstract text is available yet for this article.
June 12, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28602670/the-applicability-of-the-american-college-of-cardiology-appropriate-use-criteria-for-myocardial-perfusion-scintigraphy-in-australia
#13
Chee Loong Chow, Francis A Ponnuthurai, Kevin C Allman, William van Gaal
BACKGROUND: The American College of Cardiology (ACC) Appropriate Use Criteria (AUC) for radionuclide myocardial perfusion scans (MPS) was developed to promote its rational use in the assessment of stable ischaemic heart disease (IHD). We sought to validate the applicability of this document in the Australian context. METHODS: 1009 consecutive patients who underwent MPS were retrospectively audited at a single major metropolitan hospital in Victoria, Australia. Appropriateness was assigned based on the 2013 ACC AUC, and common indications and predictors of positive scan results were examined...
May 17, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28598987/ethnicity-and-the-first-diagnosis-of-a-wide-range-of-cardiovascular-diseases-associations-in-a-linked-electronic-health-record-cohort-of-1-million-patients
#14
Julie George, Rohini Mathur, Anoop Dinesh Shah, Mar Pujades-Rodriguez, Spiros Denaxas, Liam Smeeth, Adam Timmis, Harry Hemingway
BACKGROUND: While the association of ethnic group with individual cardiovascular diseases has been studied, little is known about ethnic differences in the initial lifetime presentation of clinical cardiovascular disease in contemporary populations. METHODS AND RESULTS: We studied 1,068,318 people, aged ≥30 years and free from diagnosed CVD at baseline (90.9% White, 3.6% South Asian and 2.9% Black), using English linked electronic health records covering primary care, hospital admissions, acute coronary syndrome registry and mortality registry (CALIBER platform)...
2017: PloS One
https://www.readbyqxmd.com/read/28596432/obstructive-sleep-apnoea-and-related-comorbidities-in-incident-idiopathic-pulmonary-fibrosis
#15
Thomas Gille, Morgane Didier, Marouane Boubaya, Loris Moya, Angela Sutton, Zohra Carton, Fanny Baran-Marszak, Danielle Sadoun-Danino, Dominique Israël-Biet, Vincent Cottin, Frederic Gagnadoux, Bruno Crestani, Marie-Pia d'Ortho, Pierre-Yves Brillet, Dominique Valeyre, Hilario Nunes, Carole Planès
The objectives of this prospective study were: 1) to determine the prevalence and determinants of obstructive sleep apnoea (OSA) in patients with newly diagnosed idiopathic pulmonary fibrosis (IPF); 2) to determine whether OSA was associated with cardiovascular disease (CVD) as well as increased oxidative stress and levels of IPF biomarkers in the blood.A group of 45 patients with newly diagnosed IPF attended polysomnography. The prevalence of CVD and the severity of coronary artery calcification were investigated by high-resolution computed tomography...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28594802/-remote-results-of-carotid-endarterectomy-in-patients-with-type-2-diabetes-mellitus
#16
Iu I Kazakov, A P Kas'ianenko, N Iu Sokolova, A V Bakulina, A O Iakovlev
The authors comparatively analysed the remote results of carotid endarterectomy and risk factors for unfavourable outcomes in patients with and without type 2 diabetes mellitus (DM). The outcomes of carotid endarterectomy were studied in a total of 168 patients, with the follow-up terms up to 8 years. Depending on the presence or absence of DM, the patients were divided into two groups. Group One comprised 79 patients with an atherosclerotic lesion of the internal carotid artery and accompanying DM, with Group Two consisting of 89 non-diabetic patients...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28591770/inferolateral-early-repolarization-among-non-ischaemic-sudden-cardiac-death-victims
#17
Lauri T A Holmström, Mira A Haukilahti, Jani T Tikkanen, Aapo L Aro, Tuomas V Kenttä, Marja-Leena Kortelainen, Heikki V Huikuri, Matti J Junttila
Aim: Inferolateral early repolarization (ER) has been associated with an increased risk of sudden cardiac death (SCD). However, this association is thought to be mainly due to ischaemic SCD. The association of ER and non-ischaemic SCD has not been studied. The aim was to evaluate whether inferolateral ER is associated with non-ischaemic SCD. Methods and results: Study population consists of 275 consecutive victims of non-ischaemic SCD with 12-lead ECG and control group of general population cohort with 10 864 subjects...
June 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28587251/pharmacokinetics-and-tissue-distribution-kinetics-of-puerarin-in-rats-using-indirect-competitive-elisa
#18
Hui Kong, Xueqian Wang, Rongfeng Shi, Yan Zhao, Jinjun Cheng, Xin Yan, Xiaoman Liu, Yongzhi Wang, Meiling Zhang, Qingguo Wang, Huihua Qu
Puerarin (PUE) is a compound isolated from the roots of Pueraria lobata. We studied the pharmacokinetics and tissue distribution kinetics of PUE in Sprague-Dawley rats following intraperitoneal administration of three concentrations. Indirect competitive ELISA based on an anti-PUE monoclonal antibody was used to determine the concentration of PUE in the blood, heart, liver, spleen, lung, kidney, hippocampus, cerebral cortex, and striatum. The plasma and tissue distribution kinetic characteristics following a single injection of PUE (20, 40 and 80 mg/kg) were calculated using a non-compartment model...
June 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28579310/a-comparative-analysis-of-novel-cardiovascular-biomarkers-in-patients-with-chronic-heart-failure
#19
Michael Lichtenauer, Peter Jirak, Bernhard Wernly, Vera Paar, Ilonka Rohm, Christian Jung, Christiana Schernthaner, Johannes Kraus, Lukas J Motloch, Atilla Yilmaz, Uta C Hoppe, P Christian Schulze, Daniel Kretzschmar, Rudin Pistulli
BACKGROUND: Heart failure (HF) with reduced ejection fraction remains a major therapeutic challenge. The aim of this study was to investigate the role of novel cardiovascular biomarkers, i.e. soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR) and heart-type fatty acid binding protein (H-FABP) in patients with ischaemic (ICM) or dilative cardiomyopathy (DCM). MATERIALS AND METHODS: A total of 200 patients were enrolled in this study: 65 were diagnosed with DCM and 59 patients suffering from ICM were included...
May 31, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28575378/long-term-outcomes-of-different-ablation-strategies-for-ventricular-tachycardia-in-patients-with-structural-heart-disease-systematic-review-and-meta-analysis
#20
David F Briceño, Jorge Romero, Pedro A Villablanca, Alejandra Londoño, Juan C Diaz, Ilir Maraj, Syeda Atiqa Batul, Nidhi Madan, Jignesh Patel, Anand Jagannath, Sanghamitra Mohanty, Prasant Mohanty, Carola Gianni, Domenico Della Rocca, Ahlam Sabri, Soo G Kim, Andrea Natale, Luigi Di Biase
Aims: To compare the long-term outcomes of standard ablation of stable ventricular tachycardia (VT) vs. substrate modification, and of complete vs. incomplete substrate modification in patients with structural heart disease (SHD) presenting with VT. Methods and results: An electronic search was performed using major databases. The main outcomes were a composite of long-term ventricular arrhythmia (VA) recurrence and all-cause mortality of standard ablation of stable VT vs...
May 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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