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https://www.readbyqxmd.com/read/28214892/baicalin-attenuates-cardiac-dysfunction-and-myocardial-remodeling-in-a-chronic-pressure-overload-mice-model
#1
Yanqing Zhang, Pingping Liao, Meng'en Zhu, Wei Li, Dan Hu, Siming Guan, Long Chen
BACKGROUND/AIMS: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects of baicalin on cardiac hypertrophy induced by pressure overload and explored the potential mechanisms involved. METHODS: C57BL/6J-mice were treated with baicalin or vehicle following transverse aortic constriction or Sham surgery for up to 8 weeks, and at different time points, cardiac function and heart size measurement and histological and biochemical examination were performed...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213739/does-influence-at-work-modify-the-relation-between-high-occupational-physical-activity-and-risk-of-heart-disease-in-women
#2
Karen Allesøe, Andreas Holtermann, Reiner Rugulies, Mette Aadahl, Eleanor Boyle, Karen Søgaard
PURPOSE: To investigate whether influence at work modifies the association between demanding and strenuous occupational physical activity (OPA) and risk of ischaemic heart disease (IHD). METHODS: A sample of 12,093 nurses aged 45-64 years from the Danish Nurse Cohort Study was followed for 20.6 years by individual linkage to incident IHD in the Danish National Patient Registry. Information on OPA, influence at work, other occupational factors and known risk factors for IHD was collected by self-report in 1993...
February 17, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28207997/chronically-elevated-bilirubin-protects-from-cardiac-reperfusion-injury-in-the-male-gunn-rat
#3
Bhavisha Bakrania, Eugene F Du Toit, Kevin J Ashton, Karl-Heinz Wagner, John P Headrick, Andrew C Bulmer
AIMS: Bilirubin is associated with reduced risk of cardiovascular disease, as evidenced in conditions of mild hyperbilirubinaemia (Gilbert's Syndrome). Little is known regarding myocardial stress-resistance in hyperbilirubinemic conditions or whether life-long exposure modifies cardiac function, which might contribute to protection from cardiovascular disease. METHODS: Hyperbilirubinemic rats and littermate controls underwent echocardiography at 3, 6 and 12 mo of age, with hearts subsequently assessed for resistance to 30 min of ischaemia...
February 16, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28204828/tieg1-deficiency-confers-enhanced-myocardial-protection-in-the-infarcted-heart-by-mediating-the-pten-akt-signalling-pathway
#4
Mingqiu Cen, Pengfei Hu, Zhaobin Cai, Tianfu Fang, Jiancheng Zhang, Ming Lu
The transforming growth factor (TGF)-β-inducible early gene-1 (TIEG1) plays a crucial role in modulating cell apoptosis and proliferation in a number of diseases, including pancreatic cancer, leukaemia and osteoporosis. However, the functional role of TIEG1 in the heart has not been fully defined. In this study, we first investigated the role of TIEG1 in ischaemic heart disease. For in vitro experiments, cardiomyocytes were isolated from both TIEG1 knockout (KO) and wile-type (WT) mice, and the apoptotic ratios were evaluated after a 48‑h ischaemic insult...
February 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28187168/outcomes-of-ventricular-tachycardia-ablation-in-patients-with-structural-heart-disease-the-impact-of-electrical-storm
#5
Bashar Aldhoon, Dan Wichterle, Petr Peichl, Robert Čihák, Josef Kautzner
AIMS: To investigate predictors of long-term outcomes after catheter ablation (CA) for ventricular tachycardia (VT) and the impact of electrical storm (ES) prior to index ablation procedures. METHODS: We studied consecutive patients with structural heart disease and VT (n = 328; age: 63±12 years; 88% males; 72% ischaemic cardiomyopathy; LVEF: 32±12%) who had undergone CA. According to presenting arrhythmia at baseline, they were divided into ES (n = 93, 28%) and non-ES groups...
2017: PloS One
https://www.readbyqxmd.com/read/28182567/risk-of-cardiovascular-disease-among-patients-with-sarcoidosis-a-population-based-retrospective-cohort-study-1976-2013
#6
Patompong Ungprasert, Cynthia S Crowson, Eric L Matteson
A higher incidence of cardiovascular disease (CVD) has been observed in several chronic inflammatory diseases. However, data on sarcoidosis are limited.In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976-2013 were identified based on comprehensive medical record review. 345 sex- and age-matched comparators were also identified from the same underlying population. Medical records were individually reviewed for CVD, including coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular accident, transient ischaemic attack, peripheral arterial disease and abdominal aortic aneurysm...
December 23, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28176973/changes-in-ischaemic-ecg-abnormalities-and-subsequent-risk-of-cardiovascular-disease
#7
Takeshi Sawai, Hironori Imano, Isao Muraki, Mina Hayama-Terada, Yuji Shimizu, Renzhe Cui, Akihiko Kitamura, Masahiko Kiyama, Takeo Okada, Tetsuya Ohira, Kazumasa Yamagishi, Mitsumasa Umesawa, Tomoko Sankai, Hiroyasu Iso
OBJECTIVE: The prognostic importance of changes in ischaemic ECG abnormalities over time (especially ST-T abnormalities) among Asians has not been fully investigated. We examined the associations between changes in ischaemic abnormalities upon serial ECG (improvement, persistence, deterioration) and cardiovascular disease (CVD) risk. METHODS: A prospective study cohort was conducted with 9374 men and women aged 40-69 years in four communities. Participants had multiple ECGs at study entry and during the next 10 years, and were followed up for a median period of 23...
2017: Heart Asia
https://www.readbyqxmd.com/read/28168827/auckland-cataract-study-2-clinical-outcomes-of-phacoemulsification-cataract-surgery-in-a-public-teaching-hospital
#8
Bia Z Kim, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: A contemporary benchmark for the most common ophthalmic surgery. BACKGROUND: To assess patient characteristics and outcomes of contemporary phacoemulsification cataract surgery in a New Zealand public teaching hospital setting. DESIGN: Prospective observational study. PARTICIPANTS: Consecutive cases (N = 500) of phacoemulsification surgery between April and June 2015. METHODS: An independent observer assessed all clinical and surgical data pre-operatively and 4-6 weeks post-operatively...
February 7, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28167486/removal-of-all-ovarian-tissue-versus-conserving-ovarian-tissue-at-time-of-hysterectomy-in-premenopausal-patients-with-benign-disease-study-using-routine-data-and-data-linkage
#9
Jemma Mytton, Felicity Evison, Peter J Chilton, Richard J Lilford
OBJECTIVE:  To conduct a nationwide study of associations between removal of all ovarian tissue versus conservation of at least one ovary at the time of hysterectomy and important health outcomes (ischaemic heart disease, cancer, and all cause mortality). STUDY DESIGN AND SETTING:  Retrospective analysis of the English Hospital Episode Statistics database linked to national registers of deprivation indices and of deaths. PARTICIPANTS:  113 679 patients aged 35-45 who had had a hysterectomy for benign conditions between April 2004 and March 2014...
February 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28165383/a-comparison-of-spatio-temporal-disease-mapping-approaches-including-an-application-to-ischaemic-heart-disease-in-new-south-wales-australia
#10
Craig Anderson, Louise M Ryan
The field of spatio-temporal modelling has witnessed a recent surge as a result of developments in computational power and increased data collection. These developments allow analysts to model the evolution of health outcomes in both space and time simultaneously. This paper models the trends in ischaemic heart disease (IHD) in New South Wales, Australia over an eight-year period between 2006 and 2013. A number of spatio-temporal models are considered, and we propose a novel method for determining the goodness-of-fit for these models by outlining a spatio-temporal extension of the Moran's I statistic...
February 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28164802/the-clinical-use-of-stress-echocardiography-in-non-ischaemic-heart-disease-recommendations-from-the-european-association-of-cardiovascular-imaging-and-the-american-society-of-echocardiography
#11
Patrizio Lancellotti, Patricia A Pellikka, Werner Budts, Farooq A Chaudhry, Erwan Donal, Raluca Dulgheru, Thor Edvardsen, Madalina Garbi, Jong Won Ha, Garvan C Kane, Joe Kreeger, Luc Mertens, Philippe Pibarot, Eugenio Picano, Thomas Ryan, Jeane M Tsutsui, Albert Varga
A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynamics under physiological or pharmacological conditions. Due to its diagnostic and prognostic value, SE has become widely implemented to assess various conditions other than ischaemic heart disease. It has thus become essential to establish guidance for its applications and performance in the area of non-ischaemic heart disease...
February 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28163831/endothelial-progenitor-cells-exploring-the-pleiotropic-effects-of-statins
#12
REVIEW
Kully Sandhu, Mamas Mamas, Robert Butler
Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct and or death after a myocardial infarction, prior to any significant change in lipid profile. Therefore, pleiotropic mechanisms, other than lowering lipid profile alone, must account for this effect. One such proposed pleiotropic mechanism is the ability of statins to augment both number and function of endothelial progenitor cells...
January 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28158544/one-in-four-major-ischaemic-heart-disease-events-are-fatal-and-60-are-pre-hospital-deaths-a-national-data-linkage-study-anzacs-qi-8
#13
Corina Grey, Rod Jackson, Morten Schmidt, Majid Ezzati, Perviz Asaria, Daniel J Exeter, Andrew J Kerr
No abstract text is available yet for this article.
January 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28157267/myocardial-fibrosis-biomedical-research-from-bench-to-bedside
#14
REVIEW
Mariann Gyöngyösi, Johannes Winkler, Isbaal Ramos, Quoc-Tuan Do, Hüseyin Firat, Kenneth McDonald, Arantxa González, Thomas Thum, Javier Díez, Frédéric Jaisser, Anne Pizard, Faiez Zannad
Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur in response to cardiac ischaemic insults, systemic diseases, drugs, or any other harmful stimulus affecting the circulatory system or the heart itself. Myocardial fibrosis alters the architecture of the myocardium, facilitating the development of cardiac dysfunction, also inducing arrhythmias, influencing the clinical course and outcome of heart failure patients. Focusing on myocardial fibrosis may potentially improve patient care through the targeted diagnosis and treatment of emerging fibrotic pathways...
February 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28143840/educational-intervention-to-improve-effectiveness-in-treatment-and-control-of-patients-with-high-cardiovascular-risk-in-low-resource-settings-in-argentina-study-protocol-of-a-cluster-randomised-controlled-trial
#15
Pablo Gulayin, Vilma Irazola, Alfredo Lozada, Martin Chaparro, Marilina Santero, Laura Gutierrez, Rosana Poggio, Andrea Beratarrechea, Adolfo Rubinstein
INTRODUCTION: Hypercholesterolaemia is estimated to cause 2.6 million deaths annually and one-third of the cases of ischaemic heart disease. In Argentina, the prevalence of hypercholesterolaemia increased between 2005 and 2013 from 27.9% to 29.8%. Only one out of four subjects with a self-reported diagnosis of coronary heart disease is taking statins. Since 2014, statins (simvastatin 20 mg) are part of the package of drugs provided free-of-charge for patients according to cardiovascular disease (CVD) risk stratification...
January 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28134590/supervised-exercise-therapy-in-the-management-of-peripheral-arterial-disease-an-assessment-of-compliance
#16
Thomas M Aherne, Elrasheid A H Kheirelseid, Michael Boland, Shane Carr, Thekra Al-Zabi, Khalid Bashar, Daragh Moneley, Austin Leahy, Noel McCaffrey, Peter Naughton
BACKGROUND: Supervised exercise therapy (SET) is an effective option in the management of peripheral arterial disease (PAD). Unfortunately, poor compliance remains prevalent. This study aimed to assess patient exercise compliance and to identify factors influencing symptomatic improvement and SET participation. PATIENTS AND METHODS: Data regarding attendance at SET for this cohort study were extracted from a prospectively maintained database of patients with claudication attending SET at Dublin City University...
January 30, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28132542/-atypical-complaint-in-myocardial-ischaemia-belching
#17
Nóra Turi-Kováts, Hrisula Arabadzisz, András Zsoldos, János Tomcsányi
While educating non-medical personnel on acute coronary syndrome we often emphasize the importance of early recognition and urgent transfer to acute cardiac center of patients with acute myocardial infarction. Aside from typical symptoms of chest tightness and pain radiating to shoulder, arm and jaw, angina often presents with atypical, non-cardiac complaints. These symptoms, often suggesting gastrointestinal problems, can sometimes mislead even the most experienced physicians. We would like to present the case of an 83-year-old woman with several decades long history of ischaemic heart disease, who recently developed a new anginal symptom: lound, uncontrollable belching...
February 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28130690/the-role-of-patient-s-systemic-characteristics-and-plateletcrit-in-developing-toxic-anterior-segment-syndrome-after-uneventful-phaco-surgery-a-case-control-study
#18
Serpil Yazgan, Ugur Celik, Orhan Ayar, Suat Hayri Ugurbas, Burcu Celik, Mehmet Orçun Akdemir, Silay Canturk Ugurbas, Atilla Alpay
PURPOSE: To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. DESIGN: A retrospective case-control study. METHODS: The study group consisted of 26 eyes of 26 patients who underwent uneventful phaco surgery and who went on to develop TASS, while the control group included 39 subjects who had routine phaco surgery in the same session by the same surgeon...
January 27, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28122419/factors-influencing-choice-of-pre-hospital-transportation-of-patients-with-potential-acute-coronary-syndrome-an-observational-study
#19
Tim Lavery, Jaimi H Greenslade, William A Parsonage, Tracey Hawkins, Emily Dalton, Christopher Hammett, Louise Cullen
OBJECTIVE: To determine factors associated with ambulance use in patients with confirmed and potential acute coronary syndrome presenting to the ED. METHODS: A convenience sample of patients (n = 247) presenting to the ED from April 2014 to January 2015 with suspected acute coronary syndrome were included in the study. Data on mode of transport and patient demographics were collected from the Emergency Department Information System database. Clinical data were collected from chart records and information systems...
January 25, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28121181/resting-heart-rate-trajectories-and-myocardial-infarction-atrial-fibrillation-ischaemic-stroke-and-death-in-the-general-population-the-troms%C3%A3-study
#20
Ekaterina Sharashova, Tom Wilsgaard, Maja-Lisa Løchen, Ellisiv B Mathiesen, Inger Njølstad, Tormod Brenn
Background Resting heart rate is an established risk factor for cardiovascular disease, but long-term individual resting heart rate trajectories and their effect on cardiovascular disease morbidity and mortality have not yet been described. Methods This large population-based longitudinal study included 14,208 men and women aged 20 years or older, not pregnant and not using blood pressure medications, who attended at least two of the three Tromsø Study surveys conducted between 1986-2001. Resting heart rate was measured using an automated Dinamap device...
January 1, 2017: European Journal of Preventive Cardiology
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