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valvular heart diseases

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https://www.readbyqxmd.com/read/29332266/association-between-the-interferon-gamma-874-t-a-polymorphism-and-the-severity-of-valvular-damage-in-patients-with-rheumatic-heart-disease
#1
Erhan Teker, A Basak Akadam-Teker, Oguz Ozturk, Allison Pinar Eronat, Kivanc Yalin, S Ebru Golcuk, Zehra Bugra
Interferon gamma (IFN-γ) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-γ +874 T/A polymorphism and the severity of valvular damage in the Turkish population. The IFN-γ genotypes were determined in 152 RHD patients and 151 healthy controls by ARMS-PCR...
January 13, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29329764/-analysis-of-mortality-and-hospital-stay-in-cardiac-surgery-in-mexico-2015-data-from-the-national-cardiology-institute
#2
Alejandra Rodríguez-Hernández, Martha García-Torres, Eduardo Bucio Reta, Francisco Martín Baranda-Tovar
OBJECTIVE: To analyse hospital mortality in patients subjected to cardiac surgery in Mexico during the year 2015, and identify the mortality risks factors, and its correlation with days of hospital stay in the cardiovascular intensive care unit. METHOD: The database of Cardiovascular Intensive Care of the National Institute of Cardiology was examined for this cases and controls study that included only adult patients subjected to cardiac surgery during the year 2015...
January 9, 2018: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29326109/current-recommendations-for-anticoagulant-therapy-in-patients-with-valvular-heart-disease-and-atrial-fibrillation-the-acc-aha-and-esc-eacts-guidelines-in-harmony%C3%A2-but-not-lockstep
#3
EDITORIAL
John Preston Erwin, Bernard Iung
No abstract text is available yet for this article.
January 11, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29325012/systematic-review-of-the-cost-effectiveness-of-transcatheter-interventions-for-valvular-heart-disease
#4
Gialama Fotini, Prezerakos Panagiotis, Apostolopoulos Vasilis, Nikolaos Maniadakis
Objectives: Transcatheter aortic valve implantation (TAVI) and transcatheter mitral valve repair (TMVR) are increasingly used for managing patients with valvular heart disease to whom surgery presents a high-risk. As these are costly procedures, a systematic review of studies concerned with their economic assessment was undertaken. Methods: The search was performed in PubMed and the Cochrane Library and followed recommended methodological steps. Studies were screened and their data were retrieved and were synthesized using a narrative approach...
January 9, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29324479/a-systematic-review-of-epidemiology-treatment-and-prognosis-of-heart-failure-in-adults-in-ethiopia
#5
Tenaadam A Tsega, Biniyam G Demissei
BACKGROUND: Systematic characterization of heart failure in adults in Ethiopia is lacking currently. In this review, we sought to summarize the available scientific evidence on the epidemiology, treatment and prognosis of heart failure in adults in Ethiopia. METHODS: A systematic review of PUBMED, EMBASE and SCOPUS was conducted for studies published between January 1990 and July 2017. Studies reporting on incidence, prevalence, treatment or prognosis of heart failure in individuals older than 14 years of age were included...
January 10, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29322712/a-cross-sectional-study-of-cardiovascular-involvement-in-systemic-lupus-erythematosus-in-an-urban-indian-tertiary-care-centre-with-emphasis-on-2-d-echocardiography
#6
Seema Kini, Chetan Vekhande, Vikram Londhey
Background: Cardiovascular manifestations are responsible for considerable morbidity and mortality in patients with SLE. A wide range of manifestations due to active lupus, like pericarditis, valvular affection, myocarditis, and less commonly pulmonary hypertension, are described. This study was undertaken to study cardiovascular manifestations in SLE, with a focus on echocardiography findings, in an urban Indian setting. Methodology: Fifty consecutive cases of SLE following up in the Rheumatology Clinic of TNMC and BYL Nair Charitable hospital, an Indian tertiary care hospital were studied...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29315310/dysregulation-of-valvular-interstitial-cell-let-7c-mir-17-mir-20a-and-mir-30d-in-naturally-occurring-canine-myxomatous-mitral-valve-disease
#7
Vicky K Yang, Albert K Tai, Terry P Huh, Dawn M Meola, Christine M Juhr, Nicholas A Robinson, Andrew M Hoffman
Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. In primary VIC lines from diseased and control valves, miRNA expression was profiled using RT-qPCR and next generation sequencing...
2018: PloS One
https://www.readbyqxmd.com/read/29305714/diagnoses-of-cardiovascular-disease-or-substance-addiction-abuse-in-us-adults-treated-for-adhd-with-stimulants-or-atomoxetine-is-use-consistent-with-product-labeling
#8
Kathleen A Fairman, Lindsay E Davis, Alyssa M Peckham, David A Sclar
BACKGROUND: Among US adults, utilization of pharmacotherapy for attention-deficit hyperactivity disorder (ADHD) has increased more than ninefold since 1995-1996. Potential contraindications to ADHD pharmacotherapy include serious cardiovascular disease (CVD) and, for stimulants, addictions and bipolar disorder (BPD). OBJECTIVE: To assess the prevalence of potential contraindications among adults treated with ADHD pharmacotherapy. METHODS: A retrospective cohort analysis was performed using the Truven Health MarketScan® database...
January 5, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29302947/fenfluramine-phentermine-is-associated-with-an-increase-in-cellular-proliferation-ex-vivo-and-in-vitro
#9
Nalini M Rajamannan
BACKGROUND: Fenfluraminephentermine (FenPhen) has been implicated in accelerated valvular heart disease, characterized by valvular regurgitation and thickening, and resembling the histopathologic lesions found in carcinoid. The study aim was to determine whether cellular proliferation is present in FenPhen-exposed valves, by utilizing an in-vitro model to test whether FenPhen has a direct mitogenic effect on cardiac valvular cells, as compared to serotonin. METHODS: Ex-vivo valves were tested for proliferation in surgically removed FenPhen-exposed valves (n = 10) and compared to proliferation levels in normal human cardiac valves removed at autopsy (n = 10)...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29302263/radiofrequency-catheter-ablation-of-atrioventricular-nodal-reentry-tachycardia-in-children-and-adolescents-a-single-center-experience
#10
Myung Chul Hyun
Purpose: Atrioventricular nodal reentry tachycardia (AVNRT) is less common in pediatric patients than in adult patients. Thus, data for pediatric AVNRT patients are insufficient. Hence, we aimed to analyze the patient characteristics, treatment, and any recurrences in pediatric AVNRT patients. Methods: We reviewed the records of 50 pediatric AVNRT patients who had undergone radiofrequency catheter ablation (RFCA) between January 1998 and December 2016 at a single regional center...
December 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29301463/hospitalization-associated-disability-in-older-adults-with-valvular-heart-disease-incidence-risk-factors-and-its-association-with-care-processes
#11
Maren Jonckers, Bastiaan Van Grootven, Ester Willemyns, Miek Hornikx, Anthony Jeuris, Christophe Dubois, Marie-Christine Herregods, Mieke Deschodt
BACKGROUND: The aim of this study was to determine the incidence and recovery of hospitalisation-associated disability (HAD), the associated risk factors, and the link with care processes in patients aged 70 years or older hospitalised with valvular heart disease (VHD). METHODS: Prospective cohort study performed on the cardiology and cardiac surgery units of University Hospitals Leuven, Belgium. HAD was defined as the loss of independence to complete one of the Activities of Daily Living (ADLs) between hospital admission and discharge...
January 4, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29300877/the-year-in-cardiology-2017-valvular-heart-disease
#12
Lars Søndergaard, Antti Saraste, Christina Christersson, Alec Vahanian
No abstract text is available yet for this article.
January 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29297190/pulmonary-valve-and-right-ventricular-outflow-tract-surgery-in-adults-23-year-experience
#13
Marcin Szczechowicz, Sabreen Mkalaluh, Mina Farag, Ahmed Mashhour, Tsvetomir Loukanov, Jacek Kolcz, Matthias Karck, Alexander Weymann
BACKGROUND: Surgery of the pulmonary valve, right ventricular outflow tract, and pulmonary artery falls under the domain of paediatric cardiac surgery. However, 97 adult patients underwent such operations in our establishment from 1993 to 2016. AIM: This study aims to analyse preoperative risk factors, intraoperative data, postoperative outcomes, and long-term survival to identify the potential predictors of mortality and high-risk patients.
 METHODS: We divided our patient cohort into three groups in accordance with surgical indications: 17 patients with pulmonary valve endocarditis (group A), 70 patients with congenital defects involving the pulmonary valve (group B), and 10 patients who underwent pulmonary valve surgery for other indications, like tumor or other acquired valvular disease (group C)...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29296623/clarion-call-for-histopathological-clot-analysis-in-cryptogenic-ischemic-stroke-implications-for-diagnosis-and-treatment
#14
Sonu Bhaskar, Dennis Cordato, Cecilia Cappelen-Smith, Andrew Cheung, David Ledingham, David Celermajer, Christopher Levi
Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed "cryptogenic" complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29285810/von-willebrand-factor-revisited
#15
Senan J Yasar, Obai Abdullah, William Fay, Sudarshan Balla
Degenerative aortic valve stenosis is the most common valvular heart disease seen in developed countries. Since the implementation of transcatheter aortic valve replacement, there has been a surge of efforts to improve procedural technique as well as reduce mortality. Until recently, the mainstay method of assessment of valve implantation as well as paravalvular regurgitation has relied heavily on imaging techniques including transesophageal echocardiography and aortic root angiography. There has been a lot of scientific inquiry to identify biomarkers in the management of patients with aortic stenosis...
December 28, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29284990/the-impact-of-risk-factors-and-comorbidities-on-the-incidence-of-atrial-fibrillation
#16
Nabil Naser, Mirza Dilic, Azra Durak, Mehmed Kulic, Esad Pepic, Elnur Smajic, Zumreta Kusljugic
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in clinical practice and its prevalence increases with age. Patients who develop AF also have cardiovascular risk factors, structural heart disease, and comorbidities, all of which can increase mortality. AF causes a significant economic burden with the increasing trend in AF prevalence and hospitalizations. Research Objectives: The objective of our study is to evaluate the impact of the most common known risk factors on the incidence of atrial fibrillation as an important precursor of cardiac and cerebrovascular morbidity and mortality among our patients in Bosnia and Herzegovina during median follow up period (September 2006 - September 2016)...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29284509/should-high-risk-patients-with-concomitant-severe-aortic-stenosis-and-mitral-valve-disease-undergo-double-valve-surgery-in-the-tavr-era
#17
Pey-Jen Yu, Allan Mattia, Hugh A Cassiere, Rick Esposito, Frank Manetta, Nina Kohn, Alan R Hartman
BACKGROUND: Significant mitral regurgitation in patients undergoing transcatheter aortic valve replacement (TAVR) is associated with increased mortality. The aim of this study is to determine if surgical correction of both aortic and mitral valves in high risk patients with concomitant valvular disease would offer patients better outcomes than TAVR alone. METHODS: A retrospective analysis of 43 high-risk patients who underwent concomitant surgical aortic valve replacement and mitral valve surgery from 2008 to 2012 was performed...
December 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29284450/cardiovascular-magnetic-resonance-in-the-evaluation-of-heart-valve-disease
#18
REVIEW
G S Gulsin, A Singh, G P McCann
BACKGROUND: Over the last 25 years, cardiovascular magnetic resonance imaging (CMR) has emerged as an alternative to echocardiography for assessment of valvular heart disease (VHD). Although echo remains the first-line imaging modality for the assessment of patients with VHD, CMR can now provide a comprehensive assessment in many instances. Using a combination of techniques, CMR provides information on valve anatomy and enables quantitative analysis of the severity of the valve lesion...
December 29, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/29281101/sildenafil-for-improving-outcomes-in-patients-with-corrected-valvular-heart-disease-and-persistent-pulmonary-hypertension-a-multicenter-double-blind-randomized-clinical-trial
#19
Javier Bermejo, Raquel Yotti, Rocío García-Orta, Pedro L Sánchez-Fernández, Mario Castaño, Javier Segovia-Cubero, Pilar Escribano-Subías, José Alberto San Román, Xavier Borrás, Angel Alonso-Gómez, Javier Botas, María G Crespo-Leiro, Sonia Velasco, Antoni Bayés-Genís, Amador López, Roberto Muñoz-Aguilera, Eduardo de Teresa, José R González-Juanatey, Arturo Evangelista, Teresa Mombiela, Ana González-Mansilla, Jaime Elízaga, Javier Martín-Moreiras, José M González-Santos, Eduardo Moreno-Escobar, Francisco Fernández-Avilés
Aims: We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD). Methods and results: The sildenafil for improving outcomes after valvular correction (SIOVAC) study was a multricentric, randomized, parallel, and placebo-controlled trial that enrolled stable adults with mean pulmonary artery pressure ≥ 30 mmHg who had undergone a successful valve replacement or repair procedure at least 1 year before inclusion...
December 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29277857/percutaneous-mitral-valve-interventions-and-heart-failure
#20
Abhishek Sharma, Sunny Goel, Sahil Agarwal
Mitral regurgitation (MR) is the most frequent Valvular Heart Disease (VHD) and is an important cause of heart failure. MR can be caused by primary valve abnormality (Degenerative MR/Primary MR) or it can be secondary to cardiomyopathy (Functional MR/Secondary MR). Medical management alleviates symptoms but does not alter the progression of the disease. Current guidelines recommend surgery for moderate-to-severe (Grade > 3) MR in patients with symptoms or evidence of left ventricular dysfunction. Despite current practice guidelines, the majority of patients with severe MR do not undergo surgery...
December 27, 2017: Advances in Experimental Medicine and Biology
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