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Syringic acid

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https://www.readbyqxmd.com/read/29350343/syringic-acid-a-phenolic-acid-promotes-osteoblast-differentiation-by-stimulation-of-runx2-expression-and-targeting-of-smad7-by-mir-21-in-mouse-mesenchymal-stem-cells
#1
B Arumugam, K Balagangadharan, N Selvamurugan
Syringic acid (SA), a phenolic acid, has been used in Chinese and Indian medicine for treating diabetes but its role in osteogenesis has not yet been investigated. In the present study, at the molecular and cellular levels, we evaluated the effects of SA on osteoblast differentiation. At the cellular level, there was increased alkaline phosphatase (ALP) activity and calcium deposition by SA treatment in mouse mesenchymal stem cells (mMSCs). At the molecular level, SA treatment of these cells stimulated expression of Runx2, a bone transcription factor, and of osteoblast differentiation marker genes such as ALP, type I collagen, and osteocalcin...
January 19, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29333387/physicochemical-and-antioxidant-properties-of-honeys-from-the-sundarbans-mangrove-forest-of-bangladesh
#2
M Rabiul Islam, Tahmina Pervin, Hemayet Hossain, Badhan Saha, Sheikh Julfikar Hossain
This study evaluated the physicochemical, nutritional, antioxidant, and phenolic properties of ten honey samples from the Sundarbans mangrove forest, Bangladesh. The average pH, electrical conductivity, total dissolved solid, ash, moisture, hydroxymethyl furfural, titrable acidity, and absorbance were 4.3, 0.38 mS/cm, 187.5 ppm, 0.14%, 17.88%, 4.4 mg/kg, 37.7 meq/kg, and 483 mAU, respectively. In the honeys, the average contents of Ca, Cu, Fe, K, Mg, Mn, and Na were 95.5, 0.19, 6.4, 302, 39.9, 3.4, and 597 ppm, respectively, whereas Cd, Cr, Pb, and Ni were not found...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29329862/active-compounds-antioxidant-activity-and-%C3%AE-glucosidase-inhibitory-activity-of-different-varieties-of-chaenomeles-fruits
#3
Jing Miao, Xia Li, Chengcheng Zhao, Xiaoxiao Gao, Ying Wang, Wenyuan Gao
Chaenomeles is an important source for food industry in China, and its planting area is expanding year by year. This study was conducted to evaluate different varieties of Chaenomeles by comparing the chemical compositions, antioxidant activity and α-glucosidase inhibitory activity of peels and fleshes from twelve varieties of Chaenomeles. In the results, peels of Chaenomeles contain more phenolics, flavonoids and triterpenes, and show better antioxidant activity and α-glucosidase inhibitory activity than their fleshes...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29327072/naproxen-is-transformed-via-acetogenesis-and-syntrophic-acetate-oxidation-by-a-methanogenic-wastewater-consortium
#4
Sarah J Wolfson, Abigail W Porter, Julia K Campbell, Lily Y Young
Over-the-counter pharmaceutical compounds can serve as microbial substrates in wastewater treatment processes as well as in the environment. The metabolic pathways and intermediates produced during their degradation, however, are poorly understood. In this study, we investigate an anaerobic wastewater community that metabolizes naproxen via demethylation. Enriched cultures, established from anaerobic digester inocula receiving naproxen as the sole carbon source, transformed naproxen to 6-O-desmethylnaproxen (DMN) within 22 days...
January 11, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29310216/an-on-line-solid-phase-extraction-disc-packed-with-a-phytic-acid-induced-3d-graphene-based-foam-for-the-sensitive-hplc-pda-determination-of-bisphenol-a-migration-in-disposable-syringes
#5
Qiuhong Yao, Yufeng Feng, Connieal Tan, Shujun Xia, Li Zhao, Shuya Wang, Yiru Wang, Xi Chen
In this study, an on-line SPE-disc filled with phytic acid induced 3D graphene-based foam (PAGF) has been applied to the determination of the migration of bisphenol A (BPA) in disposable syringes. The approach is of quick, easy, sensitive and environmentally-friendly. Experimental conditions were investigated and optimized including the character of enriched material and the amount of migrated BPA under different temperature, time and pH conditions. The experimental results reveal that the approach presents a wide linear range between the signal response and the concentration of BPA from 1 to 1000ngmL-1, as well as the detection limit of 0...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29306012/preliminary-study-and-bioinformatics-analysis-on-the-potential-role-of-cagq-in-type-iv-secretion-system-of-h-pylori
#6
Yizheng Yao, Yixin Shen, Linqi Zhu, Ying Ni, Hua Wang, Shihe Shao
Helicobacter pylori (H.pylori), is a major causative agent of chronic gastritis, gastric carcinoma and duodenal ulcer. Remarkably, H.pylori carries cytotoxin-associated gene pathogenicity island (CagPAI) which encodes a type IV secretion system (T4SS). T4SS is capable of forming a syringe-like structure to deliver oncoprotein cytotoxin-associated Antigen (CagA) into gastric epithelial cells and resulting in a cascade of events in host cells, such as induction of pro-inflammatory cytokines, alteration of cellular gene expression and cytoskeletal rearrangements...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29282887/air-assisted-dispersive-liquid-liquid-microextraction-based-on-a-new-hydrophobic-deep-eutectic-solvent-for-the-preconcentration-of-benzophenone-type-uv-filters-from-aqueous-samples
#7
Dandan Ge, Yi Zhang, Yixiu Dai, Shumin Yang
Deep eutectic solvents are considered as new and green solvents that can be widely used in analytical chemistry such as microextraction. In the present work, a new dl-menthol-based hydrophobic deep eutectic solvent was synthesized and used as extraction solvents in an air-assisted dispersive liquid-liquid microextraction method for preconcentration and extraction of benzophenone-type UV filters from aqueous samples followed by high-performance liquid chromatography with diode array detection. In an experiment, the deep eutectic solvent formed by dl-menthol and decanoic acid was added to an aqueous solution containing the UV filters, and then the mixture was sucked up and injected five times by using a glass syringe, and a cloudy state was achieved...
December 28, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29278307/biotransformation-of-plant-derived-phenolic-acids
#8
REVIEW
Ruchanok Tinikul, Pirom Chenprakhon, Somchart Maenpuen, Pimchai Chaiyen
Phenolic acids are abundant biomass feedstock that can be derived from the processing of lignin or other byproducts from agro-industrial waste. Although phenolic acids such as p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, vanillic acid, cinnamic acid, gallic acid, syringic acid and ferulic acid can be used directly in various applications, their value can be significantly increased when they are further modified to high value-added compounds. This review summarizes and discusses the new advances in cell free and whole-cell biocatalysis technologies for reactions important for conversion of phenolic acids including esterification, decarboxylation, amination, halogenation, hydroxylation and ring-breakage reactions...
December 26, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29247285/antioxidant-based-eutectics-of-irbesartan-viable-multicomponent-forms-for-the-management-of-hypertension
#9
Jamshed Haneef, Renu Chadha
The present research work highlights the development of multicomponent solid form of the antihypertensive drug irbesartan (IRB) to improve its biopharmaceutical attributes. Mechanochemical synthesis of a new solid form of IRB with coformers having antioxidant properties (syringic acid, nicotinic acid, and ascorbic acid) resulted into three eutectic mixtures (EMs). Formation of eutectic was ascertained by differential scanning calorimetry whereas exact stoichiometry (50/50% w/w) was established by phase diagram and Tamman's triangle...
December 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29229878/uptake-of-phenolic-compounds-from-plant-foods-in-human-intestinal-caco-2-cells
#10
Gavirangappa Hithamani, Dhanya Kizhakayil, Krishnapura Srinivasan
In continuation of our studies on the bioaccessibility of phenolic compounds from food grains as influenced by domestic processing, we examined the uptake of phenolics from native/sprouted finger millet (Eleucine coracana) and green gram (Vigna radiata) and native/heat-processed onion (Allium cepa) in human Caco-2 cells. Absorption of pure phenolic compounds, as well as the uptake of phenolic compounds from finger millet, green gram, and onion, was investigated in Caco-2 monolayer model. Transport of individual phenolic compounds from apical compartment to the basolateral compartment across Caco-2 monolayer was also investigated...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29228826/synthesis-physicochemical-properties-and-ocular-pharmacokinetics-of-thermosensitive-in-situ-hydrogels-for-ganciclovir-in-cytomegalovirus-retinitis-treatment
#11
Qiyue Wang, Chunmeng Sun, Bohui Xu, Jiasheng Tu, Yan Shen
Ganciclovir (GCV) is one of the most widely used antiviral drugs for the treatment of cytomegalovirus (CMV) retinitis. In this context, the aim of this study was to design in situ thermosensitive hydrogels for GCV ocular delivery by intravitreal injection to achieve sustained drug release behavior and improved ocular bioavailability in the treatment of CMV retinitis. A thermosensitive poly-(β-butyrolactone-co-lactic acid)-polyethylene glycol-poly (β-butyrolactone-co-lactic acid) (PBLA-PEG-PBLA) triblock copolymer was synthesized by ring-opening polymerization and characterization...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29227020/determination-of-herbicides-in-environmental-water-samples-by-simultaneous-in-syringe-magnetic-stirring-assisted-dispersive-liquid-liquid-microextraction-and-silylation-followed-by-gc-ms
#12
Ruth Suárez, Sabrina Clavijo, Alba González, Víctor Cerdà
An on line, fast, simple, selective and sensitive method has been developed for the determination of three herbicides belonging to the following families: triazines (atrazine), chloroacetamide (alachlor) and phenoxy (2,4-dichlorophenoxyacetic acid) in water samples. The method involves an in-syringe magnetic stirring-assisted dispersive liquid-liquid microextraction along with simultaneous silylation prior to their determination by gas chromatography with mass spectrometry. Extraction, derivatization and preconcentration have been simultaneously performed using acetone as dispersive solvent, N-methyl-N-tert-butyldimethylsilyltrifluoroacetamide as derivatization agent and trichloroethylene as extraction solvent...
December 11, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29223063/phytochemical-study-of-the-trunk-bark-of-citharexylum-spinosum-l-growing-in-tunisia-isolation-and-structure-elucidation-of-iridoid-glycosides
#13
Ilyes Saidi, Pierre Waffo-Téguo, Asma E L Ayeb-Zakhama, Fethia Harzallah-Skhiri, Axel Marchal, Hichem Ben Jannet
A phytochemical investigation of the trunk bark ethyl acetate extract of Citharexylum spinosum L. has led to the isolation of four previously undescribed iridoid glycosides, tunispinosides A-D, and five known phenylethanoid glycosides, verbascoside, leucosceptoside A, martynoside, isoverbascoside and plantainoside C, together with 4-hydroxy-2,6-dimethoxyphenyl 6'-O-vanilloyl-β-D-glucopyranoside, two 8,3'-neolignan glycosides, plucheosides D1-D2, coniferyl aldehyde, vanillic acid, syringic acid, ferulic acid and tyrosol...
December 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29211033/in-vitro-and-in-vivo-antioxidant-and-anti-hyperglycemic-activities-of-moroccan-oat-cultivars
#14
Ilias Marmouzi, El Mostafa Karym, Nezha Saidi, Bouchra Meddah, Mourad Kharbach, Azlarab Masrar, Mounya Bouabdellah, Layachi Chabraoui, Khalid El Allali, Yahia Cherrah, My El Abbes Faouzi
Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, p-hydroxybenzoic, caffeic, salicylic, syringic, sinapic, p-coumaric and chlorogenic acids...
December 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29206116/new-pharmaceutical-salts-containing-pyridoxine
#15
Aleksandar Cvetkovski, Valeria Ferretti, Valerio Bertolasi
Two mixed crystals were obtained by crystallizing the active pharmaceutical ingredient pyridoxine [systematic name: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, PN] with (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid (ferulic acid) and 4-hydroxy-3,5-dimethoxybenzoic acid (syringic acid). PN and the coformers crystallize in the form of pharmaceutical salts in a 1:1 stoichiometric ratio, namely 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, C8H12NO3+·C9H9O5-, and 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium 4-hydroxy-3,5-dimethoxybenzoate monohydrate, C8H12NO3+·C10H11O5-·H2O, the proton exchange between PN and the acidic partner being supported by the differences of the pKa values of the two components and by the C-O bond lengths of the carboxylate groups...
December 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29201056/development-of-a-rapid-and-simple-method-to-remove-polyphenols-from-plant-extracts
#16
Imali Ranatunge, Subshini Adikary, Piumi Dasanayake, Chamira Dilanka Fernando, Preethi Soysa
Polyphenols are secondary metabolites of plants, which are responsible for prevention of many diseases. Polyvinylpolypyrrolidone (PVPP) has a high affinity towards polyphenols. This method involves the use of PVPP column to remove polyphenols under centrifugal force. Standards of gallic acid, epigallocatechin gallate, vanillin, and tea extracts (Camellia sinensis) were used in this study. PVPP powder was packed in a syringe with different quantities. The test samples were layered over the PVPP column and subjected to centrifugation...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/29195662/differentiation-of-modern-and-ancient-varieties-of-common-wheat-by-quantitative-capillary-electrophoretic-profile-of-phenolic-acids
#17
Roberto Gotti, Elisa Amadesi, Jessica Fiori, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli
Phenolic compounds have received great attention among the health promoting phytochemicals in common wheat (Triticum aestivum L.), mainly because of their strong antioxidant properties. In the present study a simple Capillary Zone Electrophoresis (CZE) method with UV detection was optimized and validated for the quantitation of six of the most important phenolic acids in whole grain i.e., sinapic, ferulic, syringic, p-coumaric, vanillic and p-hydroxybenzoic acid. The separation was achieved in a running buffer composed of sodium phosphate solution (50 mM) in water/methanol 80:20 (v/v) at pH 6...
November 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29174441/hollow-microneedle-mediated-micro-injections-of-a-liposomal-hpv-e743-63-synthetic-long-peptide-vaccine-for-efficient-induction-of-cytotoxic-and-t-helper-responses
#18
Koen van der Maaden, Jeroen Heuts, Marcel Camps, Maria Pontier, Anton Terwisscha van Scheltinga, Wim Jiskoot, Ferry Ossendorp, Joke Bouwstra
Recent studies have shown that intradermal vaccination has great potential for T cell-mediated cancer immunotherapy. However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a digitally controlled hollow microneedle injection system (DC-hMN-iSystem) with an ultra-low dead volume was developed to perform micro-injections (0.25-10μL) into skin in an automated manner. A synthetic long peptide derived from human papilloma virus formulated in cationic liposomes, which was used as a therapeutic cancer vaccine, was administered intradermally by using the DC-hMN-iSystem...
November 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29174315/workshop-report-nucleic-acid-delivery-devices-for-hiv-vaccines-workshop-proceedings-national-institute-of-allergy-and-infectious-diseases-bethesda-maryland-usa-may-21-2015
#19
Bruce G Weniger, Ian E Anglin, Tina Tong, Michael Pensiero, Jeffrey K Pullen
On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tissues of animal models and humans. Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities...
November 21, 2017: Vaccine
https://www.readbyqxmd.com/read/29166774/a-syringic-acid-derivative-and-two-iridoid-glycosides-from-the-roots-of-stachys-geobombycis-and-their-antioxidant-properties
#20
Xianli Zhou, Sixin Huang, Pengcheng Wang, Qin Luo, Xiao Huang, Qin Xu, Jiangke Qin, Chengqin Liang, Xu Chen
A new derivative of syringic acid, stageobester A (1) and two iridoid glycosides which including a new one, stageoboside A (2), were isolated from the roots of Stachys geobombycis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all the isolates were tested for their antioxidant capacity. Compounds 1 and 2 showed moderate antioxidant activities against DPPH radical, with IC50 values of 113.33 ± 1.53 and 40.33 ± 2.08 mg/L, respectively...
November 22, 2017: Natural Product Research
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