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8-hydroxy-2-deoxyguanosine

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https://www.readbyqxmd.com/read/28963060/dna-versus-rna-oxidation-in-parkinson-s-disease-which-is-more-important
#1
K Gmitterová, J Gawinecka, U Heinemann, P Valkovič, I Zerr
BACKROUND: 8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurodegenerative disorders. OBJECTIVE: The primary aim of our study was to assess the differences of investigated markers between patient groups and subsequently study the influence of clinical factors that might modify the levels of investigated markers during the disease progression...
September 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28960787/antioxidant-activities-of-novel-resveratrol-analogs-in-breast-cancer
#2
Anwesha Chatterjee, Amruta Ronghe, Subhash B Padhye, David A Spade, Nimee K Bhat, Hari K Bhat
The objective of the present study was to characterize the role of novel resveratrol (Res) analogs: 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1, 2-diol} (HPIMBD) and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) as potent antioxidants against breast cancer. Non-neoplastic breast epithelial cell lines MCF-10A and MCF-10F were treated with 17β-estradiol (E2), Res, HPIMBD, and TIMBD for up to 72 h. mRNA and protein levels of antioxidant genes, superoxide dismutase 3 (SOD3) and N-quinoneoxidoreductase-1 (NQO1) and transcription factors, nuclear factor erythroid 2-related factor (Nrf) 1, 2 and 3 were quantified after the above treatments...
September 28, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28959650/use-of-anabolic-androgenic-steroids-produces-greater-oxidative-stress-responses-to-resistance-exercise-in-strength-trained-men
#3
Hamid Arazi, Heidar Mohammadjafari, Abbas Asadi
The aim of this study was to determine the effect of anabolic androgenic steroids (AAS) use on oxidative stress responses to a single session of resistance exercise in strength-trained men. Twenty-three strength trained men, with 11 self-reporting regular AAS use and 12 self-reporting never taking AAS (NAAS) volunteered to participate in this study. Blood draws were obtained pre and post resistance exercise in order to evaluate changes in oxidative stress biomarkers levels (i.e., 8-hydroxy-2-deoxyguanosine [8-OHdG], malondialdehyde [MDA], and nitric oxide [NO]), antioxidant defense systems (i...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28946755/elevated-dna-damage-oxidative-stress-and-impaired-response-defense-system-inflicted-in-patients-with-myocardial-infarction
#4
Sumayya Shahzad, Asif Hasan, Abul Faiz Faizy, Somaiya Mateen, Naureen Fatima, Shagufta Moin
BACKGROUND: Ischemic tissue damage in myocardial infarction (MI) is allied with the exaggerated production of reactive oxygen species (ROS) beyond the countering capability of chain-breaking radical scavengers, fallouts in the form of oxidatively burdened myocardial tissue. METHODS: One hundred and twenty five patients with MI were included in the study to evaluate the dynamics of redox status of patients by monitoring the antioxidant potential, biomarkers of oxidative stress, lipid indices, RBC membrane damage when compared to healthy individuals in patients with MI congregated on the basis of Global Registry of Acute Coronary Events (GRACE) score, risk factors, and age...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28938766/dietary-effects-of-bacillus-subtilis-fmbj-on-the-antioxidant-capacity-of-broilers-at-an-early-age
#5
Lili Zhang, Kaiwen Bai, Jingfei Zhang, Wen Xu, Qiang Huang, Tian Wang
This study was designed to evaluate the usage of Bacillus subtilis fmbj (BS fmbj) in broiler diets, and its effects on the antioxidant capacity of broilers at an early age. A total of 240 day-old male Arbor Acres (AA) broilers were randomly assigned to 4 groups, namely the control (CON) group (fed basal diets with 0 cfu/kg BS fmbj), the BS-1 group (fed basal diet with 0.2 × 1011 cfu/kg BS fmbj), BS-2 group (fed basal diet with 0.3 × 1011 cfu/kg BS fmbj), and BS-3 group (fed basal diet with 0.4 × 1011 cfu/kg BS fmbj)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28929426/the-protective-effect-of-whole-honey-and-phenolic-extract-on-oxidative-dna-damage-in-mice-lymphocytes-using-comet-assay
#6
Ni Cheng, Yuan Wang, Wei Cao
In this study, the antioxidant activity and the protective effect against hydrogen peroxide-induced DNA damage were assessed for five honeys of different botanical origin. Seven phenolic acids were detected in the honey samples. Ferulic acid was the most abundant phenolic acid detected in longan honey, jujube honey and buckwheat honey. Ellagic acid, p-hydroxybenzoic acid and protocatechuic acid were the main phenolic acids detected in vitex honey. Of all honey samples tested, the highest total phenolic content and antioxidant activity were found in buckwheat honey, whereas the lowest total phenolic content and antioxidant activity were found in locust honey...
September 19, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28869188/risk-assessment-of-environmental-exposure-to-heavy-metals-in-mothers-and-their-respective-infants
#7
Iman Al-Saleh, Reem Al-Rouqi, Rola Elkhatib, Mai Abduljabbar, Tahreer Al-Rajudi
Exposure to heavy metals can cause renal injury, which has been well documented in occupational exposure. Studies of low exposure in the general population, however, are still scarce, particularly for vulnerable populations such as mothers and young children. This study evaluated exposure to heavy metals, and biomarkers of renal function and oxidative stress in 944 lactating mothers and their infants and investigated the role of the interaction between heavy metals and oxidative stress in altering renal function...
August 4, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28867383/protective-effects-of-kinetin-against-aluminum-chloride-and-d-galactose-induced-cognitive-impairment-and-oxidative-damage-in-mouse
#8
Yunpeng Wei, Dan Liu, Yin Zheng, Honglian Li, Chaoshuang Hao, Wuqing Ouyang
Increasing evidence indicates that aluminum exposure and oxidative stress play crucial roles in the initiation and development of Alzheimer's disease (AD). Aluminum chloride (AlCl3) and d-galactose (d-gal) combined treatment of mice is considered as an easy and cheap way to obtain an animal model of AD. Kinetin is a plant cytokinin, which is also reported to exert neuro-protective effects in vivo and in vitro. Thus, in this study, neuro-protective effects of kinetin were investigated in an AD model of mice induced by AlCl3 and d-gal...
September 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28866865/increased-levels-of-mitochondrial-dna-copy-number-in-patients-with-vitiligo
#9
H Vaseghi, M Houshmand, Z Jadali
BACKGROUND: Oxidative stress is known to be involved in the pathogenesis of autoimmune diseases such as vitiligo. Evidence suggests that the human mitochondrial DNA copy number (mtDNAcn) is vulnerable to damage mediated by oxidative stress. The purpose of this study was to examine and compare peripheral blood mtDNAcn and oxidative DNA damage byproducts (8-hydroxy-2-deoxyguanosine; 8-OHdG) in patients with vitiligo and healthy controls (HCs). METHODS: The relative mtDNAcn and the oxidative damage (formation of 8-OHdG in mtDNA) of each sample were determined by real-time quantitative PCR...
October 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28844187/evaluation-of-oxidative-status-in-patients-with-chronic-periodontitis-and-polycystic-ovary-syndrome-a-cross-sectional-study
#10
Ebru Saglam, Cenk Fatih Canakcı, Saime Ozbek Sebin, Nesrin Saruhan, Metin Ingec, Hümeyra Canakcı, Ufuk Sezer
BACKGROUND: The aim of the present study was to investigate the salivary and serum 8-hydroxy-2´-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels as well as total antioxidant status (TAS), in females with chronic periodontitis (CP) and polycystic ovary syndrome (PCOS), compared to healthy females. METHODS: Four groups, each consisting of 22 individuals, respectively women with both PCOS and CP (PCOSCP), systemically healthy women with CP (CP), periodontally healthy women with PCOS (PCOSPH) and periodontally and systemically healthy women (PH)...
August 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28834388/dry-eye-disease-and-oxidative-stress
#11
REVIEW
Sophia Seen, Louis Tong
Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease...
August 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28830012/early-oxidative-stress-dna-damage-and-inflammation-resulting-from-subcutaneous-injection-of-sulfur-mustard-into-mice
#12
Xiaorui Zhang, Yizhou Mei, Tongxing Wang, Feng Liu, Ning Jiang, Wenxia Zhou, Yongxiang Zhang
Oxidative stress, DNA damage repair, and inflammation are three important reactions of sulfur mustard (SM) exposure. But molecular related chronological events in the earlier stage of SM exposure model are still unclear. In the research, reactive oxygen species (ROS) was measured by using flow cytometry. Cytokines were tested in Luminex method. Myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS), 8-hydroxy-2-deoxyguanosine (8-OHdG) and glutathione (GSH) activity or levels in serum were determined by commercially available kits...
July 17, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28808206/the-effect-of-sunblock-against-oxidative-stress-in-farmers-a-pilot-study
#13
Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Ji Yeoun Lee, Heon Kim
Farmers are frequently exposed to ultraviolet (UV) radiation which causes various diseases by inducing oxidative stress. This study aimed to assess the effects of sunblock on oxidative stress in the body. Eighty-seven farmers were divided into two groups: those who wore sunblock for five days and those who did not. The total antioxidant capacity (TAC) in urine, which is an antioxidant indicator, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in urine, an oxidative stress indicator, were measured. The urinary TAC of sunblock users was significantly higher than that of non-users, but urinary 8-OHdG levels were not significantly different...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28774949/renoprotective-effect-of-topiroxostat-via-antioxidant-activity-in-puromycin-aminonucleoside-nephrosis-rats
#14
Yosuke Kawamorita, Takeshi Shiraishi, Yoshifuru Tamura, Takanori Kumagai, Shigeru Shibata, Yoshihide Fujigaki, Makoto Hosoyamada, Takahiko Nakagawa, Shunya Uchida
Topiroxostat is a novel inhibitor of xanthine oxidase, and is postulated to exert a renoprotective effect. Puromycin aminonucleoside nephrosis (PAN) is a rat model of minimal change nephrotic syndrome. In this study, we examined whether topiroxostat ameliorates the kidney injury in PAN rats that was induced by a single intraperitoneal injection of PA (100 mg/kg body weight). Rats were divided into four groups: control rats, PAN rats, control rats treated with topiroxostat (1.0 mg/kg/day), and PAN rats treated with topiroxostat...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28754587/8-hydroxy-2-deoxyguanosine-ameliorates-high-fat-diet-induced-insulin-resistance-and-adipocyte-dysfunction-in-mice
#15
Joo Young Huh, Inji Jung, Lingjuan Piao, Hunjoo Ha, Myung-Hee Chung
8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been recently shown to exert anti-inflammatory effects through inhibition of Rac1. Inflammation in adipose tissue is a hallmark of obesity-induced insulin resistance, but the therapeutic potential of 8-OHdG in treatment of metabolic diseases has not been fully elucidated. The aim of this study was to examine the effect of exogenously administered 8-OHdG on adipose tissue and whole body metabolism. In cultured adipocytes, 8-OHdG inhibited adipogenesis and reversed TNFα-induced insulin resistance...
September 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28726514/increased-blood-8-hydroxy-2-deoxyguanosine-levels-in-methamphetamine-users-during-early-abstinence
#16
Ming-Chyi Huang, Ying-Ching Lai, Shih-Ku Lin, Chun-Hsin Chen
BACKGROUND: Reactive oxygen species (ROS) are thought to play a role in the adverse physical and mental consequences of methamphetamine usage. The oxidative DNA adduct 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a well-known biomarker of ROS-induced DNA damage. Currently, there is insufficient clinical information about methamphetamine-induced oxidative DNA damage. OBJECTIVES: This study examined differences in blood levels of 8-OHdG between methamphetamine users and non-users as well as alterations in 8-OHdG levels after 2 weeks of methamphetamine abstinence...
July 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28650728/minor-constituents-in-rice-bran-oil-and-sesame-oil-play-a-significant-role-in-modulating-lipid-homeostasis-and-inflammatory-markers-in-rats
#17
Poorna C R Yalagala, Dhavamani Sugasini, Talahalli Ravichandra Ramaprasad, Belur Ramaswamy Lokesh
The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented with 10 wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver, and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28646259/chronic-administration-of-s-allylcysteine-activates-nrf2-factor-and-enhances-the-activity-of-antioxidant-enzymes-in-the-striatum-frontal-cortex-and-hippocampus
#18
Úrzula Franco-Enzástiga, Ricardo A Santana-Martínez, Carlos A Silva-Islas, Diana Barrera-Oviedo, María Elena Chánez-Cárdenas, Perla D Maldonado
Oxidative stress plays an important role in neurodegenerative diseases and aging. The cellular defense mechanisms to deal with oxidative damage involve the activation of transcription factor related to NF-E2 (Nrf2), which enhances the transcription of antioxidant and phase II enzyme genes. S-allylcysteine (SAC) is an antioxidant with neuroprotective properties, and the main organosulfur compound in aged garlic extract. The ability of SAC to activate the Nrf2 factor has been previously reported in hepatic cells; however this effect has not been studied in normal brain...
June 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28612585/pancreatic-cancer-is-associated-with-peripheral-leukocyte-oxidative-dna-damage
#19
Ashraf Mohamadkhani, Akram Pourshams, Jessica Viti, Filippo Cellai, Kamran Mortazavi, Maryam Sharafkhah, Masoud Sotoudeh, Reza Malekzadeh, Paolo Boffetta, Marco Peluso
Background: DNA damage accumulation has been linked to the cancer phenotype. The purpose of this study was to compare the levels of DNA base 8-hydroxy-2′-deoxyguanosine (8-OHdG) and C-reactive protein (CRP) inflammatory markers in healthy controls and pancreatic cancer patients from a hospital-based case-control study. Materials and Methods: Fifty-five pancreatic cancer patients and 55 healthy controls were enrolled from a pool of patients referred to the Endoscopic Ultrasound (EUS) center. Analysis of DNA content of peripheral blood cells was conducted for 8-OHdG with the 32P-postlabelling assay...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28551561/oxidative-stress-and-respiratory-symptoms-due-to-human-exposure-to-polycyclic-aromatic-hydrocarbons-pahs-in-kumasi-ghana
#20
Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M M Nakayama, Kwadwo A Asante, Elvis Baidoo, Christian Obirikorang, Aksorn Saengtienchai, Norikazu Isoda, Collins Nimako, Hazuki Mizukawa, Mayumi Ishizuka
Studies of polycyclic aromatic hydrocarbons (PAHs) and its metabolites in PM10, soils, rat livers and cattle urine in Kumasi, Ghana, revealed high concentrations and cancer potency. In addition, WHO and IARC have reported an increase in cancer incidence and respiratory diseases in Ghana. Human urine were therefore collected from urban and control sites to: assess the health effects associated with PAHs exposure using malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG); identify any association between OH-PAHs, MDA, 8-OHdG with age and sex; and determine the relationship between PAHs exposure and occurrence of respiratory diseases...
September 2017: Environmental Pollution
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