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8-hydroxy-2-deoxyguanosine

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https://www.readbyqxmd.com/read/29454986/nano-sized-tio-2-ntio-2-induces-metabolic-perturbations-in-physarum-polycephalum-macroplasmodium-to-counter-oxidative-stress-under-dark-conditions
#1
Zhi Zhang, Zhi Cheng Liang, Jian Hua Zhang, Sheng Li Tian, Jun Le Qu, Jiao Ning Tang, Shi De Liu
Nano-sized TiO2 (nTiO2 ) exerts an oxidative effect on cells upon exposure to solar or UV irradiation and ecotoxicity of the nTiO2 is an urgent concern. Little information is available regarding the effect of TiO2 on cells under dark conditions. Metabolomics is a unique approach to the discovery of biomarkers of nTiO2 cytotoxicity, and leads to the identification of perturbed metabolic pathways and the mechanism underlying nTiO2 toxicity. In the present study, gas chromatography mass spectrometry (GC/MS)-based metabolomics was performed to investigate the effect of nTiO2 on sensitive cells (P...
February 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454324/investigation-of-the-anti-cataractogenic-mechanisms-of-curcumin-through-in-vivo-and-in-vitro-studies
#2
Jing Cao, Tao Wang, Meng Wang
BACKGROUND: Cataract is the leading cause of blindness in elderly people worldwide, especially in developing countries. Studies to identify strategies that can prevent or retard cataract formation are urgently required. This study aimed to investigate the potential mechanism of the cytoprotective effects of curcumin in in vivo and in vitro experiments. METHODS: Male Wistar rats were randomly divided into three groups: the control group, the model group (administered 20 μmol/kg sodium selenite), and the curcumin group (pretreated with 75 mg/kg body weight curcumin 24 h prior to the administration of sodium selenite)...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29448021/risk-assessment-of-silica-nanoparticles-on-liver-injury-in-metabolic-syndrome-mice-induced-by-fructose
#3
Jianmei Li, Xiwei He, Yang Yang, Mei Li, Chenke Xu, Rong Yu
This study aims to assess the effects and the mechanisms of silica nanoparticles (SiNPs) on hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose. Here, we found that SiNPs exposure lead to improved insulin resistance in metabolic syndrome mice, but markedly worsened hepatic ballooning, inflammation infiltration, and fibrosis. Moreover, SiNPs exposure aggravated liver injury in metabolic syndrome mice by causing serious DNA damage. Following SiNPs exposure, liver superoxide dismutase and catalase activities in metabolic syndrome mice were stimulated, which is accompanied by significantly increased malondialdehyde and 8-hydroxy-2-deoxyguanosine levels as compared to normal mice...
February 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29250610/increased-neuronal-dna-rna-oxidation-in-the-frontal-cortex-of-mice-subjected-to-unpredictable-chronic-mild-stress
#4
Alfred M Maluach, Keith A Misquitta, Thomas D Prevot, Corey Fee, Etienne Sibille, Mounira Banasr, Ana C Andreazza
Background: Chronic stress is implicated in the development of various psychiatric illnesses including major depressive disorder. Previous reports suggest that patients with major depressive disorder have increased levels of oxidative stress, including higher levels of DNA/RNA oxidation found in postmortem studies, especially within brain regions responsible for the cognitive and emotional processes disrupted in the disorder. Here, we aimed to investigate whether unpredictable chronic mild stress in mice induces neuronal DNA/RNA oxidation in the prelimbic, infralimbic, and cingulate cortices of the frontal cortex and the basolateral amygdala and to explore potential associations with depressive-like behaviors...
January 2017: Chronic Stress
https://www.readbyqxmd.com/read/29234143/risk-of-glomerular-filtration-rate-decline-in-patients-with-hypertrophic-cardiomyopathy-and-obstructive-sleep-apnoea
#5
Shao-Yun Wang, Jing Luo, Yi-Fei Dong, Xu-Yang Liu, Ying-Li Fan, Ming Deng, Da-Wei Chen, Ping Li, Xiao-Shu Cheng
Sleep apnoea is associated with chronic kidney diseases. A high obstructive sleep apnoea (OSA) prevalence is shown in patients with hypertrophic cardiomyopathy (HCM). Whether the presence of OSA would affect the renal function of patients with HCM is unknown. Forty-five consecutive patients with HCM were divided into the HCM OSA- and OSA+ groups. Forty-three patients with OSA without HCM were recruited as controls. Clinical indices, including estimated glomerular filtration rate (eGFR) and urine 8-hydroxy-2-deoxyguanosine (8-OHdG), were measured...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168129/flavone-protects-hbe-cells-from-dna-double-strand-breaks-caused-by-pm2-5
#6
Xing Ren, Yong Tang, Jiameng Sun, Jianbo Feng, Leilei Chen, Huixi Chen, Sijing Zeng, Changhui Chen, Xinqiu Li, Haixia Zhu, Zhaojun Zeng
Ambient air particulate matter 2.5 (PM2.5) contains many harmful components that can enter the circulatory system and produce reactive oxygen species (ROS) in body. Oxidative stress and DNA damage induced by ROS may affect any cellular macromolecule and lead to DNA double-strand breaks (DSBs). Flavonoids, widely distributed in some herbs and berries, have been proved having anti-oxidative or anti-cancer efficacy. In this study, we investigated whether Flavone, a kind of flavonoids, can protect human bronchial epithelial cells (HBE) from DSBs caused by PM2...
November 22, 2017: Human Cell
https://www.readbyqxmd.com/read/29142399/the-effect-of-thymoquinone-on-nuclear-factor-kappa-b-levels-and-oxidative-dna-damage-on-experimental-diabetic-rats
#7
Ayşe Usta, Semiha Dede
Background: Thymoquinone (TQ), the basic bioactive phytochemical constituent of seed oil of Nigella sativa, is one of these herbal drugs known for antidiabetic effects. This study was carried out to assess the effects of the possible role of TQ on nuclear factor kappa B (NF-κB) and oxidative DNA damage levels in experimental diabetic rats. Materials and Methods: Twenty-eight male Wistar Albino rats (200-250 g) were used as experimental subjects. The rats were divided into four groups, including the control, control supplemented with TQ (CT), diabetic (D), and diabetic supplemented with TQ (DT), each containing seven rats...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29126143/understanding-how-dogs-age-longitudinal-analysis-of-markers-of-inflammation-immune-function-and-oxidative-stress
#8
Janet E Alexander, Alison Colyer, Richard M Haydock, Michael G Hayek, JeanSoon Park, Rafael de Cabo
As in human populations, advances in nutrition and veterinary care have led to an increase in the lifespan of companion animals. Detrimental physiological changes occurring later in life must be understood before interventions can be made to slow or reduce them. One important aspect of human aging is upregulation of the inflammatory response and increase in oxidative damage resulting in pathologies linked to chronic inflammation. To determine whether similar processes occur in the aging dog, changes in markers of inflammation and oxidative stress were investigated in 80 Labrador retrievers from adulthood to the end of life...
November 6, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29111472/assessment-of-8-hydroxy-2-deoxyguanosine-activity-gene-expression-and-antioxidant-enzyme-activity-on-rainbow-trout-oncorhynchus-mykiss-tissues-exposed-to-biopesticide
#9
Gonca Alak, Arzu Ucar, Veysel Parlak, Aslı Çilingir Yeltekin, Ismail Hakkı Taş, Doğukan Ölmez, Esat Mahmut Kocaman, Mustafa Yılgın, Muhammed Atamanalp, Telat Yanık
The goal of this study was to determinate toxicity mechanism of biopesticide with antioxidant enzymes parameters such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and malondialdehyde (MDA) levels, oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), transcriptional changes of heat shock protein 70 (HSP70), and cytochromes P4501A (CYP1A), sod, cat, and gpx in liver and gill tissues of Oncorhynchus mykiss. For this aim, plant-based (natural pesticides, azadirachtin (AZA)) and synthetic pesticides (deltamethrin (DLM)) were exposed on the fish at different concentrations (0...
December 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29076300/improvement-of-persistent-detrusor-overactivity-through-treatment-with-a-phytotherapeutic-agent-wsy-1075-after-relief-of-bladder-outlet-obstruction
#10
Su Jin Kim, Seung Hwan Jeon, Eun Bi Kwon, Hyun Cheol Jeong, Sae Woong Choi, Woong Jin Bae, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Sung Yeoun Hwang, Sae Woong Kim
PURPOSE: Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of the phytotherapeutic agent WSY-1075 on persistent detrusor overactivity (DO) after the relief of bladder outlet obstruction (BOO). MATERIALS AND METHODS: Rats were assigned to 3 groups: control (n=6), persistent DO (n=6), and persistent DO treated with the phytotherapeutic agent WSY-1075 (n=6). Persistent DO after relief of partial BOO was generated in the rat model, and 6 of the rats with this condition were orally administered WSY-1075...
October 25, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29068452/alleviation-of-oxidative-stress-mediated-nephropathy-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-and-onion-allium-cepa-in-streptozotocin-induced-diabetic-rats
#11
Seetur R Pradeep, Krishnapura Srinivasan
Oxidative stress plays a major role in the progression of diabetes and the pathogenesis of diabetic nephropathy. In this study, the beneficial influence of dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) on oxidative stress-mediated renal injury was evaluated in streptozotocin-induced diabetic rats. Diabetes was induced in adult Wistar rats by the administration of streptozotocin (i.p. 45 mg kg(-1)). Dietary interventions were made with 10% fenugreek seeds or 3% onion (freeze-dried) or their combination for 6 weeks...
October 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28963060/dna-versus-rna-oxidation-in-parkinson-s-disease-which-is-more-important
#12
K Gmitterová, J Gawinecka, U Heinemann, P Valkovič, I Zerr
BACKROUND: 8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurodegenerative disorders. OBJECTIVE: The primary aim of our study was to assess the differences of investigated markers between patient groups and subsequently study the influence of clinical factors that might modify the levels of investigated markers during the disease progression...
September 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28960787/antioxidant-activities-of-novel-resveratrol-analogs-in-breast-cancer
#13
Anwesha Chatterjee, Amruta Ronghe, Subhash B Padhye, David A Spade, Nimee K Bhat, Hari K Bhat
The objective of the present study was to characterize the role of novel resveratrol (Res) analogs: 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1, 2-diol} (HPIMBD) and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) as potent antioxidants against breast cancer. Non-neoplastic breast epithelial cell lines MCF-10A and MCF-10F were treated with 17β-estradiol (E2), Res, HPIMBD, and TIMBD for up to 72 h. mRNA and protein levels of antioxidant genes, superoxide dismutase 3 (SOD3) and N-quinoneoxidoreductase-1 (NQO1) and transcription factors, nuclear factor erythroid 2-related factor (Nrf) 1, 2 and 3 were quantified after the above treatments...
September 28, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28959650/use-of-anabolic-androgenic-steroids-produces-greater-oxidative-stress-responses-to-resistance-exercise-in-strength-trained-men
#14
Hamid Arazi, Heidar Mohammadjafari, Abbas Asadi
The aim of this study was to determine the effect of anabolic androgenic steroids (AAS) use on oxidative stress responses to a single session of resistance exercise in strength-trained men. Twenty-three strength trained men, with 11 self-reporting regular AAS use and 12 self-reporting never taking AAS (NAAS) volunteered to participate in this study. Blood draws were obtained pre and post resistance exercise in order to evaluate changes in oxidative stress biomarkers levels (i.e., 8-hydroxy-2-deoxyguanosine [8-OHdG], malondialdehyde [MDA], and nitric oxide [NO]), antioxidant defense systems (i...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28946755/elevated-dna-damage-oxidative-stress-and-impaired-response-defense-system-inflicted-in-patients-with-myocardial-infarction
#15
Sumayya Shahzad, Asif Hasan, Abul Faiz Faizy, Somaiya Mateen, Naureen Fatima, Shagufta Moin
BACKGROUND: Ischemic tissue damage in myocardial infarction (MI) is allied with the exaggerated production of reactive oxygen species (ROS) beyond the countering capability of chain-breaking radical scavengers, fallouts in the form of oxidatively burdened myocardial tissue. METHODS: One hundred and twenty five patients with MI were included in the study to evaluate the dynamics of redox status of patients by monitoring the antioxidant potential, biomarkers of oxidative stress, lipid indices, RBC membrane damage when compared to healthy individuals in patients with MI congregated on the basis of Global Registry of Acute Coronary Events (GRACE) score, risk factors, and age...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28938766/dietary-effects-of-bacillus-subtilis-fmbj-on-the-antioxidant-capacity-of-broilers-at-an-early-age
#16
Lili Zhang, Kaiwen Bai, Jingfei Zhang, Wen Xu, Qiang Huang, Tian Wang
This study was designed to evaluate the usage of Bacillus subtilis fmbj (BS fmbj) in broiler diets, and its effects on the antioxidant capacity of broilers at an early age. A total of 240 day-old male Arbor Acres (AA) broilers were randomly assigned to 4 groups, namely the control (CON) group (fed basal diets with 0 cfu/kg BS fmbj), the BS-1 group (fed basal diet with 0.2 × 1011 cfu/kg BS fmbj), BS-2 group (fed basal diet with 0.3 × 1011 cfu/kg BS fmbj), and BS-3 group (fed basal diet with 0.4 × 1011 cfu/kg BS fmbj)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28929426/the-protective-effect-of-whole-honey-and-phenolic-extract-on-oxidative-dna-damage-in-mice-lymphocytes-using-comet-assay
#17
Ni Cheng, Yuan Wang, Wei Cao
In this study, the antioxidant activity and the protective effect against hydrogen peroxide-induced DNA damage were assessed for five honeys of different botanical origin. Seven phenolic acids were detected in the honey samples. Ferulic acid was the most abundant phenolic acid detected in longan honey, jujube honey and buckwheat honey. Ellagic acid, p-hydroxybenzoic acid and protocatechuic acid were the main phenolic acids detected in vitex honey. Of all honey samples tested, the highest total phenolic content and antioxidant activity were found in buckwheat honey, whereas the lowest total phenolic content and antioxidant activity were found in locust honey...
September 19, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28869188/risk-assessment-of-environmental-exposure-to-heavy-metals-in-mothers-and-their-respective-infants
#18
Iman Al-Saleh, Reem Al-Rouqi, Rola Elkhatib, Mai Abduljabbar, Tahreer Al-Rajudi
Exposure to heavy metals can cause renal injury, which has been well documented in occupational exposure. Studies of low exposure in the general population, however, are still scarce, particularly for vulnerable populations such as mothers and young children. This study evaluated exposure to heavy metals, and biomarkers of renal function and oxidative stress in 944 lactating mothers and their infants and investigated the role of the interaction between heavy metals and oxidative stress in altering renal function...
November 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28867383/protective-effects-of-kinetin-against-aluminum-chloride-and-d-galactose-induced-cognitive-impairment-and-oxidative-damage-in-mouse
#19
Yunpeng Wei, Dan Liu, Yin Zheng, Honglian Li, Chaoshuang Hao, Wuqing Ouyang
Increasing evidence indicates that aluminum exposure and oxidative stress play crucial roles in the initiation and development of Alzheimer's disease (AD). Aluminum chloride (AlCl3) and d-galactose (d-gal) combined treatment of mice is considered as an easy and cheap way to obtain an animal model of AD. Kinetin is a plant cytokinin, which is also reported to exert neuro-protective effects in vivo and in vitro. Thus, in this study, neuro-protective effects of kinetin were investigated in an AD model of mice induced by AlCl3 and d-gal...
September 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28866865/increased-levels-of-mitochondrial-dna-copy-number-in-patients-with-vitiligo
#20
H Vaseghi, M Houshmand, Z Jadali
BACKGROUND: Oxidative stress is known to be involved in the pathogenesis of autoimmune diseases such as vitiligo. Evidence suggests that the human mitochondrial DNA copy number (mtDNAcn) is vulnerable to damage mediated by oxidative stress. The purpose of this study was to examine and compare peripheral blood mtDNAcn and oxidative DNA damage byproducts (8-hydroxy-2-deoxyguanosine; 8-OHdG) in patients with vitiligo and healthy controls (HCs). METHODS: The relative mtDNAcn and the oxidative damage (formation of 8-OHdG in mtDNA) of each sample were determined by real-time quantitative PCR...
October 2017: Clinical and Experimental Dermatology
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