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8-hydroxy-2-deoxyguanosine

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https://www.readbyqxmd.com/read/29926661/-improvement-of-hydrogen-on-liver-oxidative-stress-injury-in-chronic-intermittent-hypoxia-rats
#1
Sheng-Chang Yang, Ling-Ling Chen, Tian Fu, Wen-Ya Li, En-Sheng Ji
OBJECTIVE: To explore the effects of hydrogen on liver injury in chronic intermittent hypoxia rats and the related oxidative stress mechanism. METHODS: Twenty-four male adult SD rats were randomly divided into 3 groups( n =8):the normoxia group (Norm), the chronic intermittent hypoxia group (CIH), the chronic intermittent hypoxia and hydrogen group (H2 + CIH). Rats in Norm group were exposed in air, those in the other 2 groups suffered from chronic intermittent hypoxia conditions for 5 weeks...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926392/borax-supplementation-alleviates-hematotoxicity-and-dna-damage-in-rainbow-trout-oncorhynchus-mykiss-exposed-to-copper
#2
Gonca Alak, Veysel Parlak, Mehmet Enes Aslan, Arzu Ucar, Muhammed Atamanalp, Hasan Turkez
Heavy metals have harmful effects on health of both ecosystems and organisms to their accumulation ability. Copper (Cu) is an essential element for organism survival, but EPA considers Cu as a priority pollutant. On the other hand, boron has well-defined biological effects in living organisms including cytoprotection and genoprotection, although borax (BX) metabolism is poorly described in fish. Moreover, the effects of boron supplementation against Cu-induced hematotoxicity and DNA damage in aquatic organisms are still undetermined...
June 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29891761/the-effects-of-beta-hydroxy-beta-methylbutyrate-free-acid-supplementation-and-resistance-training-on-oxidative-stress-markers-a-randomized-double-blind-placebo-controlled-study
#3
Hamid Arazi, Abbas Asadi, Katsuhiko Suzuki
The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variables in responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group ( n = 8) or a placebo supplementation group ( n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed...
June 11, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29793105/copd-rat-model-is-more-susceptible-to-cold-stress-and-pm-2-5-exposure-and-the-underlying-mechanism
#4
Kai Zhang, Lei Guo, Qiaozhen Wei, Quanquan Song, Jiangtao Liu, Jingping Niu, Li Zhang, Ye Ruan, Bin Luo
The purpose of this study is to verify the hypothesis that chronic obstructive pulmonary disease (COPD) model rat is more susceptible to cold stress and fine particulate matter (PM2.5 ) exposure than the healthy rat, and explore the related mechanism. COPD rat model, established with cigarette smoke and lipopolysaccharide intratracheal instillation, were exposed to cold stress (0 °C) and PM2.5 (0, 3.2, 12.8 mg/ml). After that, the levels of superoxide dismutase, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), monocyte chemotactic protein 1 (MCP-1) and angiotensin Ⅱ (Ang-Ⅱ) in lung were measured, as well as the expression levels of lung 8-hydroxy-2-deoxyguanosine (8-OHdG), nuclear factor kappa B (NF-κB), heme-oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2)...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29782990/a-certain-role-of-sod-cat-imbalance-in-pathogenesis-of-autism-spectrum-disorders
#5
Konstantin Yenkoyan, Hayk Harutyunyan, Aida Harutyunyan
The real impact of reactive oxygen species, antioxidant enzymes, mitochondrial dysfunction and chronic inflammation on the development of autism spectrum disorders (ASD) remains unclear, and even controversial. In this study we compared the plasma levels of antioxidant enzymes and their cofactors, markers of oxidative damage, and the respiratory burst in peripheral blood polymorphonuclear leukocytes (PMNL) as surrogate marker of chronic inflammation obtained from 10 children (4-10 year old) who met DSM-5 criteria and their siblings...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29775776/the-probable-roles-of-valsartan-in-alleviating-chronic-obstructive-pulmonary-disease-following-co-exposure-to-cold-stress-and-fine-particulate-matter
#6
Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo
Angiotensin II (ANG II) might play an important role in the co-effects of cold stress and fine particulate matter (PM2.5 ) on chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate the roles of valsartan in alleviating COPD following co-exposure to cold stress and PM2.5 . Both the two intervention factors are carried out upon COPD rats with the intervention of valsartan. Blockade of angiotensin receptor by valsartan decreases the levels of malondialdehyde in the normal temperature and tumor necrosis factor-α under cold stress significantly...
May 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29753073/glycine-transporter-1-and-glycine-receptor-mediate-the-antioxidant-effect-of-glycine-in-diabetic-rat-islets-and-ins-1-cells
#7
Lei Chen, Junqing Zhang, Changhong Li, Ziwei Wang, Jingjing Li, Dan Zhao, Suxia Wang, Hong Zhang, Youyuan Huang, Xiaohui Guo
Oxidative stress is the main inducer of β-cell damage, which underlies the pathogenesis of diabetes. Evidence suggests that glycine, a recognized antioxidant, may improve β-cell function; however, its mechanism in protecting diabetic β-cells against oxidative stress has not been directly investigated. Using a streptozotocin-induced diabetic rat model and INS-1 pancreatic β-cells, we evaluated whether glycine can attenuate diabetic β-cell damage induced by oxidative stress. In diabetic rats, glycine stimulated insulin secretion; enhanced plasma glutathione (GSH), catalase and superoxide dismutase levels; reduced plasma 8-hydroxy-2 deoxyguanosine and islet p22phox levels; and improved islet β-cell mitochondrial degeneration and insulin granule degranulation...
May 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29752343/unexpected-role-of-the-human-cytomegalovirus-contribute-to-essential-hypertension-in-the-kazakh-chinese-population-of-xinjiang
#8
Qian Feng, Jing Hui, Na Tang, Yong-Min Liu, Hua Zhong, Zhen Li, La-Mei Wang, Yuan-Yuan Qu, Feng-Mei Deng, Fang He
Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin-angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension remain unclear. Our group previously demonstrated an association between EH and HCMV infection in Kazakh Chinese; Here, we investigated the relationship between HCMV infection and other clinicopathological features in 720 Kazakhs individuals with or without hypertension (n = 360 each; age, 18-80)...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29685007/neuroprotection-of-ulinastatin-on-transient-cerebral-ischemia-via-antioxidative-mechanisms
#9
H X Hu, D H Xu, W N Ju, C Ma, X Wang, X L Liu
Ulinastatin [also called urinary trypsin inhibitor (UTI)] has beneficial effects on cerebral ischemic injury evoked by cardiac arrest (CA). However, the underlying mechanisms are unknown. The purpose of this report was to determine the involvement of antioxidative signal pathway of the hippocampus in effects of UTI in the process of neurological functions after transient cerebral ischemia. CA was induced by asphyxia followed by cardiopulmonary resuscitation in rats. Western blot analysis and ELISA were used to examine expression of Nrf2-antioxidant response element (ARE) and superoxide dismutases (SOD), and the levels of products of oxidative stress...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29613814/grape-seed-procyanidins-extract-attenuates-cisplatin-induced-oxidative-stress-and-testosterone-synthase-inhibition-in-rat-testes
#10
Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang, Yingbiao Sun
Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as antisolid tumors drugs. However, it could cause testicular damage related with oxidative stress and testosterone synthesis disorder. Studies reported that grape seed procyanidins extract (GSPE) could improve CIS induced-testes lesion via scavenging free radicals in animals, although its mechanisms were unclear. Therefore, the purpose of the present study was to explore the antagonistic mechanisms of GSPE on CIS-induced testes lesion...
April 3, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29581965/involvement-of-cholinergic-dysfunction-and-oxidative-damage-in-the-effects-of-simulated-weightlessness-on-learning-and-memory-in-rats
#11
Yongliang Zhang, Qiong Wang, Hailong Chen, Xinmin Liu, Ke Lv, Tingmei Wang, Yanli Wang, Guohua Ji, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented. Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box test. Additionally, parameters about cholinergic activity and oxidative stress were tested. Results showed that longer-than-14 d HU led to the inferior performances in the behavioral tasks...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29571109/yucca-schidigera-extract-modulates-the-lead-induced-oxidative-damage-nephropathy-and-altered-inflammatory-response-and-glucose-homeostasis-in-japanese-quails
#12
Mayada R Farag, Mahmoud Alagawany, Mohamed E Abd El-Hack, Sabry A A El-Sayed, Sarah Y A Ahmed, Dalia H Samak
The present study was conducted to explore the toxic effects of lead (Pb) on the physiological responses of Japanese quails and to investigate the potential modulatory role of Yucca schidigera extract (YSE) against these effects. 360 mature Japanese quails (at 2 months of age) were used and the experiment was lasted for 8 weeks. The birds were divided into six equal groups as follow: control (basal diet, BD), BD+Pb (100 mg/kg diet), BD+YSE (100 mg/kg diet), BD+YSE (200 mg/kg diet), BD+Pb (100 mg/kg diet) +YSE (100 mg/kg diet) and BD+ Pb (100 mg/kg diet) + YSE (200 mg/kg diet)...
July 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29557530/neuroprotective-efficiency-of-mangifera-indica-leaves-extract-on-cadmium-induced-cortical-damage-in-rats
#13
Naif E Al Omairi, Omyma K Radwan, Yahea A Alzahrani, Rami B Kassab
Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 served as vehicle control group, groups 2, 3 and 4 received MLE (100, 200, 300 mg /kg b.wt, respectively). Group 5 was treated with CdCl2 (5 mg/kg b.wt). Groups 6, 7 and 8 were co-treated with MLE and CdCl2 using the same doses...
March 20, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29479980/effects-of-cinnamic-acid-on-complications-of-diabetes
#14
Hatice Gül Anlar, Merve Bacanlı, Tuğbagül Çal, Sevtap Aydın, Nuray Arı, Ülkü Ündeğer Bucurgat, Arif Ahmet Başaran, Ayşe Nurşen Başaran
Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29454986/nano-sized-tio-2-ntio-2-induces-metabolic-perturbations-in-physarum-polycephalum-macroplasmodium-to-counter-oxidative-stress-under-dark-conditions
#15
Zhi Zhang, Zhi Cheng Liang, Jian Hua Zhang, Sheng Li Tian, Jun Le Qu, Jiao Ning Tang, Shi De Liu
Nano-sized TiO2 (nTiO2 ) exerts an oxidative effect on cells upon exposure to solar or UV irradiation and ecotoxicity of the nTiO2 is an urgent concern. Little information is available regarding the effect of TiO2 on cells under dark conditions. Metabolomics is a unique approach to the discovery of biomarkers of nTiO2 cytotoxicity, and leads to the identification of perturbed metabolic pathways and the mechanism underlying nTiO2 toxicity. In the present study, gas chromatography mass spectrometry (GC/MS)-based metabolomics was performed to investigate the effect of nTiO2 on sensitive cells (P...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454324/investigation-of-the-anti-cataractogenic-mechanisms-of-curcumin-through-in-vivo-and-in-vitro-studies
#16
Jing Cao, Tao Wang, Meng Wang
BACKGROUND: Cataract is the leading cause of blindness in elderly people worldwide, especially in developing countries. Studies to identify strategies that can prevent or retard cataract formation are urgently required. This study aimed to investigate the potential mechanism of the cytoprotective effects of curcumin in in vivo and in vitro experiments. METHODS: Male Wistar rats were randomly divided into three groups: the control group, the model group (administered 20 μmol/kg sodium selenite), and the curcumin group (pretreated with 75 mg/kg body weight curcumin 24 h prior to the administration of sodium selenite)...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29448021/risk-assessment-of-silica-nanoparticles-on-liver-injury-in-metabolic-syndrome-mice-induced-by-fructose
#17
Jianmei Li, Xiwei He, Yang Yang, Mei Li, Chenke Xu, Rong Yu
This study aims to assess the effects and the mechanisms of silica nanoparticles (SiNPs) on hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose. Here, we found that SiNPs exposure lead to improved insulin resistance in metabolic syndrome mice, but markedly worsened hepatic ballooning, inflammation infiltration, and fibrosis. Moreover, SiNPs exposure aggravated liver injury in metabolic syndrome mice by causing serious DNA damage. Following SiNPs exposure, liver superoxide dismutase and catalase activities in metabolic syndrome mice were stimulated, which is accompanied by significantly increased malondialdehyde and 8-hydroxy-2-deoxyguanosine levels as compared to normal mice...
July 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29250610/increased-neuronal-dna-rna-oxidation-in-the-frontal-cortex-of-mice-subjected-to-unpredictable-chronic-mild-stress
#18
Alfred M Maluach, Keith A Misquitta, Thomas D Prevot, Corey Fee, Etienne Sibille, Mounira Banasr, Ana C Andreazza
Background: Chronic stress is implicated in the development of various psychiatric illnesses including major depressive disorder. Previous reports suggest that patients with major depressive disorder have increased levels of oxidative stress, including higher levels of DNA/RNA oxidation found in postmortem studies, especially within brain regions responsible for the cognitive and emotional processes disrupted in the disorder. Here, we aimed to investigate whether unpredictable chronic mild stress in mice induces neuronal DNA/RNA oxidation in the prelimbic, infralimbic, and cingulate cortices of the frontal cortex and the basolateral amygdala and to explore potential associations with depressive-like behaviors...
January 2017: Chronic Stress
https://www.readbyqxmd.com/read/29234143/risk-of-glomerular-filtration-rate-decline-in-patients-with-hypertrophic-cardiomyopathy-and-obstructive-sleep-apnoea
#19
Shao-Yun Wang, Jing Luo, Yi-Fei Dong, Xu-Yang Liu, Ying-Li Fan, Ming Deng, Da-Wei Chen, Ping Li, Xiao-Shu Cheng
Sleep apnoea is associated with chronic kidney diseases. A high obstructive sleep apnoea (OSA) prevalence is shown in patients with hypertrophic cardiomyopathy (HCM). Whether the presence of OSA would affect the renal function of patients with HCM is unknown. Forty-five consecutive patients with HCM were divided into the HCM OSA- and OSA+ groups. Forty-three patients with OSA without HCM were recruited as controls. Clinical indices, including estimated glomerular filtration rate (eGFR) and urine 8-hydroxy-2-deoxyguanosine (8-OHdG), were measured...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168129/flavone-protects-hbe-cells-from-dna-double-strand-breaks-caused-by-pm2-5
#20
Xing Ren, Yong Tang, Jiameng Sun, Jianbo Feng, Leilei Chen, Huixi Chen, Sijing Zeng, Changhui Chen, Xinqiu Li, Haixia Zhu, Zhaojun Zeng
Ambient air particulate matter 2.5 (PM2.5) contains many harmful components that can enter the circulatory system and produce reactive oxygen species (ROS) in body. Oxidative stress and DNA damage induced by ROS may affect any cellular macromolecule and lead to DNA double-strand breaks (DSBs). Flavonoids, widely distributed in some herbs and berries, have been proved having anti-oxidative or anti-cancer efficacy. In this study, we investigated whether Flavone, a kind of flavonoids, can protect human bronchial epithelial cells (HBE) from DSBs caused by PM2...
April 2018: Human Cell
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