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https://www.readbyqxmd.com/read/29351477/mathematical-analysis-of-circadian-disruption-and-metabolic-re-entrainment-of-hepatic-gluconeogenesis-the-intertwining-entraining-roles-of-light-and-feeding
#1
Seul-A Bae, Ioannis P Androulakis
The circadian rhythms influence the metabolic activity from molecular level to tissue, organ, and host level. Disruption of the circadian rhythms manifest to the host's health as metabolic syndromes including obesity, diabetes, and elevated plasma glucose, eventually leading to cardiovascular diseases. Therefore, it is imperative to understand the mechanism behind the relationship between circadian rhythms and metabolism. To start answering this question, we propose a semi-mechanistic mathematical model to study the effect of circadian disruption on hepatic gluconeogenesis in humans...
January 9, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29350109/tertiary-care-experience-of-sorafenib-in-the-treatment-of-progressive-radioiodine-refractory-differentiated-thyroid-carcinoma-a-korean-multicenter-study
#2
Mijin Kim, Tae Hyuk Kim, Dong Yeob Shin, Dong-Jun Lim, Eui Young Kim, Won Bae Kim, Jae Hoon Chung, YoungKee Shong, Bo Hyun Kim, Won Gu Kim
BACKGROUND: Sorafenib, a multi-kinase inhibitor, is approved for the treatment of patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). In this study, we evaluated the efficacy and safety of sorafenib in real-world clinical practice and compared the results with those of the DECISION trial. We also evaluated the clinical features associated with better clinical outcomes after sorafenib treatment. METHODS: This multicenter, retrospective cohort study evaluated 98 patients with progressive RAI-refractory DTC who were treated with sorafenib in six tertiary hospitals in Korea...
January 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29350102/preoperative-clinical-and-sonographic-predictors-for-lateral-cervical-lymph-node-metastases-in-sporadic-medullary-thyroid-carcinoma
#3
Hye-Seon Oh, Hyemi Kwon, Eyun Song, MinJi Jeon, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Suck Joon Hong, Won Bae Kim, YoungKee Shong, Jung Hwan Baek, Won Gu Kim
<b><i>Background</i></b> Total thyroidectomy and cervical lymph node (LN) dissection is generally recommended in patients with medullary thyroid carcinoma (MTC). However, there is no clear evidence for whom to perform prophylactic lateral neck dissection in MTC patients without evident lateral cervical lymph node (LCLN) metastasis in preoperative images. This study evaluated the preoperative features for predicting the LCLN metastasis of MTC. <b><i>Methods</i></b> We included 26 MTC patients with LCLN metastasis at initial surgery (N1b group) and 47 MTC patients without any LN metastasis or recurrence of disease (N0-NED group)...
January 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29349943/environmental-and-body-concentrations-of-heavy-metals-at-sites-near-and-distant-from-industrial-complexes-in-ulsan-korea
#4
Joo Hyun Sung, Inbo Oh, Ahra Kim, Jiho Lee, Chang Sun Sim, Cheolin Yoo, Sang Jin Park, Geun Bae Kim, Yangho Kim
BACKGROUND: Industrial pollution may affect the heavy metal body burden of people living near industrial complexes. We determined the average concentrations of atmospheric heavy metals in areas close to and distant from industrial complexes in Korea, and the body concentrations of these heavy metals in residents living near and distant from these facilities. METHODS: The atmospheric data of heavy metals (lead and cadmium) were from the Regional Air Monitoring Network in Ulsan...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349865/superfast-room-temperature-activation-of-sno2-thin-films-via-atmospheric-plasma-oxidation-and-their-application-in-planar-perovskite-photovoltaics
#5
Haejun Yu, Hye-In Yeom, Jong Woo Lee, Kisu Lee, Doyk Hwang, Juyoung Yun, Jaehoon Ryu, Jungsup Lee, Sohyeon Bae, Seong Keun Kim, Jyongsik Jang
The power conversion efficiency (PCE) of perovskite solar cells (PSCs) has now exceeded 20%; thus, research focus has shifted to establishing the foundations for commercialization. One of the pivotal themes is to curtail the overall fabrication time, to reduce unit cost, and mass-produce PSCs. Additionally, energy dissipation during the thermal annealing (TA) stage must be minimized by realizing a genuine low-temperature (LT) process. Here, tin oxide (SnO2 ) thin films (TFs) are formulated at extremely high speed, within 5 min, under an almost room-temperature environment (<50 °C), using atmospheric Ar/O2 plasma energy (P-SnO2 ) and are applied as an electron transport layer of a "n-i-p"-type planar PSC...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29348826/interaction-of-macrophages-with-apoptotic-cells-inhibits-transdifferentiation-and-invasion-of-lung-fibroblasts
#6
Yong-Bae Kim, Young-So Yoon, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang
The invasion of activated fibroblasts is a key mechanism of tissue fibrosis pathology. The recognition and uptake of apoptotic cells can induce the anti-fibrogenic programming of macrophages. We demonstrate that after interacting with apoptotic cells, macrophages secrete bioactive molecules that antagonize TGF-β1-induced increases in myofibroblast (fibroproliferative) phenotypic markers and reduce the enhanced invasive capacity of TGF-β1- or EGF-treated mouse lung fibroblasts (MLg). Furthermore, numerous treatment strategies prevented the anti-fibrotic effects of conditioned media, including transfection of macrophages with COX-2 or RhoA siRNAs or treatment of MLg cells with receptor antagonists for prostaglandin E2 (PGE2), PGD2, or hepatocyte growth factor (HGF)...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348730/black-ginseng-activates-akt-signaling-thereby-enhancing-myoblast-differentiation-and-myotube-growth
#7
Soo-Yeon Lee, Ga-Yeon Go, Tuan Anh Vuong, Jee Won Kim, Sullim Lee, Ayoung Jo, Jun Min An, Su-Nam Kim, Dong-Wan Seo, Jin-Seok Kim, Yong Kee Kim, Jong-Sun Kang, Sang-Jin Lee, Gyu-Un Bae
Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348685/overexpression-of-adhesion-molecules-and-barrier-molecules-is-associated-with-differential-infiltration-of-immune-cells-in-non-small-cell-lung-cancer
#8
Young Kwang Chae, Wooyoung M Choi, William H Bae, Jonathan Anker, Andrew A Davis, Sarita Agte, Wade T Iams, Marcelo Cruz, Maria Matsangou, Francis J Giles
Immunotherapy is emerging as a promising option for lung cancer treatment. Various endothelial adhesion molecules, such as integrin and selectin, as well as various cellular barrier molecules such as desmosome and tight junctions, regulate T-cell infiltration in the tumor microenvironment. However, little is known regarding how these molecules affect immune cells in patients with lung cancer. We demonstrated for the first time that overexpression of endothelial adhesion molecules and cellular barrier molecule genes was linked to differential infiltration of particular immune cells in non-small cell lung cancer...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348362/draft-genome-sequence-of-a-multistress-tolerant-yeast-pichia-kudriavzevii-ng7
#9
Hyun Joo Park, Hyeok-Jin Ko, Haeyoung Jeong, Sun Hee Lee, Hyun-Jun Ko, Jung-Hoon Bae, Bong Hyun Sung, Jong-In Han, Jung-Hoon Sohn
Pichia kudriavzevii NG7 is a multistress-tolerant yeast, isolated from grape skins. Here, we report the draft genome sequence of P. kudriavzevii NG7, to understand its biochemical regulation and metabolic pathways.
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29348335/complete-genome-sequence-of-the-african-green-monkey-simian-foamy-virus-serotype-3-strain-fv2014-sfvcae_fv2014
#10
Subhiksha Nandakumar, Eunhae H Bae, Arifa S Khan
The full-length sequence of simian foamy virus serotype 3 (SFV-3) strain FV2014, an African green monkey (Chlorocebus aethiops) isolate, was obtained using high-throughput sequencing. SFVcae_FV2014 consisted of 13,127 bp and had a genomic organization similar to those of other SFVs but was distinct from SFV strain LK3, isolated from the same monkey species.
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29348170/crispr-rna-and-anti-crispr-protein-binding-to-the-xanthomonas-albilineans-csy1-csy2-heterodimer-in-the-type-i-f-crispr-cas-system
#11
Suji Hong, Donghyun Ka, Seo Jeong Yoon, Nayoung Suh, Migyeong Jeong, Jeong-Yong Suh, Euiyoung Bae
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins provide microbial adaptive immunity against bacteriophages. In type I-F CRISPR-Cas systems, multiple Cas proteins (Csy1-4) comprise a surveillance complex (Csy complex) with CRISPR RNA (crRNA) for target recognition. Here, we report the biochemical characterization of the Csy1-Csy2 subcomplex from Xanthomonas albilineans, including the analysis of its interaction with crRNA and also AcrF2, an anti-CRISPR (Acr) protein from a phage that infects Pseudomonas aeruginosa The X...
January 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29347815/control-over-electron-phonon-interaction-by-dirac-plasmon-engineering-in-the-bi2se3-topological-insulator
#12
Chihun In, Sangwan Sim, Beom Kim, Hyemin Bae, Hyunseung Jung, Woosun Jang, Myungwoo Son, Jisoo Moon, Maryam Salehi, Seung Young Seo, Aloysius Soon, Moon-Ho Ham, Hojin Lee, Seongshik Oh, Dohun Kim, Moon-Ho Jo, Hyunyong Choi
Understanding the mutual interaction between electronic excitations and lattice vibrations is key for electronic transport and optoelectronic phenomena. Dynamic manipulation of such interaction is elusive as it requires varying the material composition on the atomic level. In turn, recent studies on topological insulators (TIs) have revealed the coexistence of a strong phonon resonance and topologically protected Dirac plasmon, both in the terahertz (THz) frequency range. Here, using these intrinsic characteristics of TIs, we demonstrate a new methodology for controlling electron-phonon interaction by lithographically engineered Dirac surface plasmons in the Bi2Se3 TI...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29347628/opposing-effects-of-cationic-antimicrobial-peptides-and-divalent-cations-on-bacterial-lipopolysaccharides
#13
Matthew Smart, Aruna Rajagopal, Wing-Ki Liu, Bae-Yeun Ha
The permeability of the bacterial outer membrane, enclosing Gram-negative bacteria, depends on the interactions of the outer, lipopolysaccharide (LPS) layer, with surrounding ions and molecules. We present a coarse-grained model for describing how cationic amphiphilic molecules (e.g., antimicrobial peptides) interact with and perturb the LPS layer in a biologically relevant medium, containing monovalent and divalent salt ions (e.g., Mg^{2+}). In our approach, peptide binding is driven by electrostatic and hydrophobic interactions and is assumed to expand the LPS layer, eventually priming it for disruption...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345591/should-antithrombotic-treatment-strategies-in-east-asians-differ-from-caucasians-focused-on-acs-or-pci-treated-patients
#14
Jae Seok Bae, Jong-Hwa Ahn, Udaya Tantry, Paul A Gurbel, Young-Hoon Jeong
With over 1.5 billion people, East Asians are the most populous race in the world. Health status in this population is an important global issue. In the contemporary trials of antithrombotic treatment, East Asian patients have a lower risk for atherothrombotic diseases (especially, coronary artery disease [CAD]) and a higher risk for bleeding (especially, gastrointestinal bleeding and hemorrhagic stroke). Despite these observations, antithrombotic treatment strategies in East Asian patients are mainly based on the American or European guidelines that are derived from randomized, controlled trials including mostly Caucasians...
January 16, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29345459/bifunctional-hybrid-catalysts-with-perovskite-laco0-8fe0-2o3-nanowires-and-reduced-graphene-oxide-sheets-for-an-efficient-li-o2-battery-cathode
#15
Jong Guk Kim, Youngmin Kim, Yuseong Noh, Seonhwa Lee, Yoongon Kim, Won Bae Kim
In this paper, bifunctional catalysts consisting of perovskite LaCo0.8Fe0.2O3 nanowires (LCFO NWs) with reduced graphene oxide (rGO) sheets were prepared for use in lithium-oxygen (Li-O2) battery cathodes. The structure and morphology of bifunctional LCFO@rGO catalysts were characterized by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The prepared LCFO@rGO composite was explored as a cathode catalyst for Li-O2 batteries, resulted in an outstanding discharge capacity (ca...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29345408/the-effect-of-eradication-of-helicobacter-pylori-on-gastric-cancer-prevention-in-healthy-asymptomatic-populations
#16
Suh Eun Bae, Kee Don Choi, Jaewon Choe, Seon Ok Kim, Hee Kyong Na, Ji Young Choi, Ji Yong Ahn, Kee Wook Jung, JeongHoon Lee, Do Hoon Kim, Hye-Sook Chang, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Although many epidemiologic studies have evaluated the effect of Helicobacter pylori eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether H. pylori eradication would affect the incidence of gastric cancer in healthy asymptomatic populations. MATERIALS AND METHODS: We performed a retrospective cohort study in 38 984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29344304/atherosclerosis-is-exacerbated-by-chitinase-3-like-1-in-amyloid-precursor-protein-transgenic-mice
#17
Yu Yeon Jung, Ki Cheon Kim, Mi Hee Park, Youngsik Seo, Heonyong Park, Min Hee Park, Jun Chang, Dae Youn Hwang, Sang Bae Han, Sanghyeon Kim, Dong Ju Son, Jin Tae Hong
Although the important role of amyloid precursor protein (APP) in vascular diseases associated with Alzheimer's disease (AD) has been demonstrated, the underlying molecular mechanisms and physiological consequences are unclear. We aimed to evaluate vascular inflammation and atherosclerosis in Swedish mutant of human APP transgenic (APPsw-Tg) and ApoE-/-/APPsw-Tg mice. We also aimed to explore the mechanisms underlying any changes observed in these mice compared with non-Tg controls. Methods: The transgenic and non-Tg mouse strains were subjected to partial ligation of the left carotid artery to induce atherosclerotic changes, which were measured using histological approaches, immunohistochemistry, quantitative polymerase chain reaction, and gene expression microarrays...
2018: Theranostics
https://www.readbyqxmd.com/read/29343847/neural-substrates-of-purely-endogenous-self-regulatory-control-of-attention
#18
Suk Won Han, Hyunji Shin, Dahee Jeong, Shinyoung Jung, Eunhee Bae, Joo Yeon Kim, Hyeon-Man Baek, Kyoheon Kim
Stimulus-driven orienting of attention toward a novel, salient stimulus is a highly adaptive behavior. In an opposing vein, it is also crucial to endogenously redirect attention to other stimuli of behavioral significance if the attended stimulus was evaluated to be unimportant. This stimulus-driven orienting and subsequent reorienting of attention are known to be mediated by similar neural substrates. However, this might be because reorienting was triggered by a sensory transition exogenously capturing attention, such as an abrupt onset of a new stimulus...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343846/author-correction-coda-integrating-multi-level-context-oriented-directed-associations-for-analysis-of-drug-effects
#19
Hasun Yu, Jinmyung Jung, Seyeol Yoon, Mijin Kwon, Sunghwa Bae, Soorin Yim, Jaehyun Lee, Seunghyun Kim, Yeeok Kang, Doheon Lee
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343784/tensile-stress-effect-on-epitaxial-bifeo3-thin-film-grown-on-ktao3
#20
In-Tae Bae, Tomohiro Ichinose, Myung-Geun Han, Yimei Zhu, Shintaro Yasui, Hiroshi Naganuma
Comprehensive crystal structural study is performed for BiFeO3 (BFO) film grown on KTaO3 (KTO) substrate using transmission electron microscopy (TEM) and x-ray diffraction (XRD). Nano-beam electron diffraction (NBED) combined with structure factor calculation and high resolution TEM images clearly reveal that the crystal structure within BFO thin film is rhombohedral BFO, i.e., bulk BFO phase. Epitaxial relationship found by NBED indicates the BFO film grows in a manner that minimizes lattice mismatch with KTO...
January 17, 2018: Scientific Reports
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