keyword
https://read.qxmd.com/read/38466274/clopidogrel-plus-aspirin-vs-aspirin-alone-in-patients-with-acute-mild-to-moderate-stroke-the-atamis-randomized-clinical-trial
#21
JOURNAL ARTICLE
Hui-Sheng Chen, Yu Cui, Xin-Hong Wang, Yu-Tong Ma, Jing Han, Ying-Jie Duan, Jiang Lu, Li-Ying Shen, Yong Liang, Wei-Zhong Wang, Hui Wang, Yong Zhao, Jin-Tao Zhang, Yu-Lin Song, Xiao-Mei He, Run-Hui Li, Ding-Bo Tao, Jing Li, Shu-Man Huang, Ni Wang, Mei Hong, Chong Meng, Wei Zhang, Duo-Lao Wang, Thanh N Nguyen
IMPORTANCE: Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking. OBJECTIVE: To evaluate whether dual antiplatelet therapy is superior to single antiplatelet among patients with mild to moderate ischemic stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter, open-label, blinded end point, randomized clinical trial conducted at 66 hospitals in China from December 20, 2016, through August 9, 2022...
March 11, 2024: JAMA Neurology
https://read.qxmd.com/read/38465813/-treatment-of-patients-with-ishemic-stroke-in-the-vertebral-basilar-system-in-acute-period-experience-of-using-the-neuroprotective-drug-mexidol
#22
JOURNAL ARTICLE
Z A Goncharova, I V Chernikova, V A Nazarova, V V Tolmacheva, K G Ovsepian
OBJECTIVE: To assess the clinical efficacy and safety of Mexidol in patients in acute period of ishemic stroke in the vertebral-basilar system (iiVBS). MATERIAL AND METHODS: An open randomized comparative study involved 52 patients. 32 of them received Mexidol (mail group, MG) and 20 received therapy without neuroprotective drugs. Assessment of the severity of clinical manifestations of iiVBS was performed using the Hoffenberth scale, stroke severity was assessed using the NIHSS, the modified Rankin Scale was used to assess the degree of disability in patients after stroke, neuropsychological examination of patients was performed using the Montreal Cognitive Assessment (MoCA), dynamics were compared on the Hospital Anxiety and Depression Scale (HADS), Subjective assessment scale for asthenia (MFI-20), the patients' quality of life was assessed using the EQ-5D...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38465097/carotid-free-floating-thrombus-treated-with-a-combined-technique-using-embotrap-iii-for-distal-protection
#23
Yoichiro Nagao, Yuichiro Inatomi, Masaki Naganuma, Toshiro Yonehara, Makoto Nakajima
Carotid free-floating thrombus (FFT) is a rare condition in patients with acute ischemic stroke. Recently, endovascular therapy for carotid FFT has been increasingly reported, but the strategy has not yet been established. We report a case of an acute stroke patient with a carotid FFT, who was successfully treated with a combination of the direct aspiration first-pass technique (ADAPT) and the Embotrap III (Cerenovus, Irvine, CA), specifically designed to prevent distal embolization. We propose the utility of distal embolic protection with Embotrap III for the treatment of patients with carotid FFT...
February 2024: Curēus
https://read.qxmd.com/read/38461762/impact-of-dementia-status-on-intravenous-thrombolysis-and-endovascular-treatment-for-acute-ischemic-stroke-retrospective-study
#24
JOURNAL ARTICLE
Jonathan Naftali, Gal Tsur, Eitan Auriel, Rani Barnea, Michael Findler, Guy Raphaeli, Ran Brauner, Keshet Pardo, Alain Perlow, Galit Weinstein, Penina Weiss, Amir Glik, Ophir Keret
INTRODUCTION: Individuals with dementia are underrepresented in interventional studies for acute ischemic stroke (AIS). This research gap creates a bias against their treatment in clinical practice. Our goal was to compare the safety and efficacy of intravenous-thrombolysis (t-PA) and endovascular treatment (EVT) in individuals with or without pre-AIS dementia. METHOD: A retrospective study of AIS patients receiving t-PA or EVT between 2019 and 2022. Patients were classified as dementia on a case-by-case review of baseline assessment...
March 7, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38460777/computed-tomography-perfusion-deficit-volume-predicts-the-functional-outcome-of-endovascular-therapy-for-basilar-artery-occlusion
#25
JOURNAL ARTICLE
Yiying Pan, Pengjun Chen, Shunyang Chen, Yanjun Li, Junhe Wang, Shuiwei Xia, Jie Rao, Ruijie Gao, Chenying Lu, Jiansong Ji
OBJECTIVES: To investigate the relationship between baseline computed tomography perfusion deficit volumes and functional outcomes in patients with basilar artery occlusion (BAO) undergoing endovascular therapy. METHODS: This was a single-center study in which the data of 64 patients with BAO who underwent endovascular therapy were retrospectively analyzed. All the patients underwent multi-model computed tomography on admission. The posterior-circulation Acute Stroke Prognosis Early Computed Tomography Score was applied to assess the ischemic changes...
March 7, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38459953/the-effectiveness-and-safety-of-human-urinary-kallidinogenase-in-acute-ischemic-stroke-patients-undergoing-endovascular-therapy
#26
JOURNAL ARTICLE
Mengmeng Wang, Changwei Guo, Jie Yang, Jing Li, Jinrong Hu, Zhouzhou Peng, Meng Guo, Lingyu Zhang, Fengli Li, Qingwu Yang, Wenjie Zi, Pengfei Wang
The effectiveness and safety of human urinary kallidinogenase (HUK) in acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) due to large vessel occlusion (LVO) was unclear. A pooled analysis was performed using individual data from the DEVT and RESCUE BT trials. Patients were divided into two groups based on HUK treatment. The primary outcome was the 90-day modified Rankin Scale (mRS) score. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH) within 48 hours...
March 9, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38459676/impact-of-carotid-stenosis-on-the-outcome-of-stroke-patients-submitted-to-reperfusion-treatments-a-narrative-review
#27
REVIEW
Giovanna Viticchi, Lorenzo Falsetti, Claudia Altamura, Chiara Di Felice, Fabrizio Vernieri, Marco Bartolini, Mauro Silvestrini
Intravenous thrombolysis (IT) and mechanical thrombectomy (MD) are the two interventional approaches that have changed the outcome of patients with acute ischemic stroke (AIS). Ipsilateral and contralateral carotid stenosis (ICS, CCS) play an important role in regulating cerebral hemodynamics, both in chronic and acute situations such as AIS. Several studies have explored their role in the incidence and severity of stroke, but very few have investigated the possible impact of ICS and CCS on the efficacy of interventional procedures...
March 11, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38458504/procedural-blood-pressure-and-contrast-extravasation-on-dual-energy-computed-tomography-after-endovascular-stroke-treatment
#28
JOURNAL ARTICLE
M M Q Robbe, F M E Pinckaers, R G C Santegoeds, M J Bos, R J van Oostenbrugge, W H van Zwam, J Staals, A A Postma
BACKGROUND: Blood brain barrier disruption (BBBD) can be visualized by contrast extravasation (CE) after endovascular treatment (EVT) in patients with acute ischemic stroke. Elevated blood pressure is a risk factor for BBBD. However, the association between procedural blood pressure and CE post-EVT is unknown. METHODS: In this single-center retrospective study, we analyzed 501 eligible patients who received a dual energy CT (DECT) immediately post-EVT for acute ischemic stroke...
March 6, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38457772/remote-ischemic-conditioning-with-medical-management-or-reperfusion-therapy-for-acute-ischemic-stroke-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Qi Li, Jinxiu Guo, Hui-Sheng Chen, Rolf Ankerlund Blauenfeldt, David C Hess, Fernando Pico, Pooja Khatri, Bruce C V Campbell, Xinggang Feng, Mohamad Abdalkader, Jeffrey L Saver, Raul G Nogueira, Bingwu Jiang, Bing Li, Min Yang, Hongfei Sang, Qingwu Yang, Zhongming Qiu, Yi Dai, Thanh N Nguyen
BACKGROUND AND OBJECTIVES: Remote ischemic conditioning (RIC) is a low-cost, accessible, and noninvasive neuroprotective treatment strategy, but its efficacy and safety in acute ischemic stroke are controversial. With the publication of several randomized controlled trials (RCTs) and the recent results of the RESIST trial, it may be possible to identify the patient population that may (or may not) benefit from RIC. This systematic review and meta-analysis aims to evaluate the effectiveness and safety of RIC in patients with ischemic stroke receiving different treatments by pooling data of all randomized controlled studies to date...
April 9, 2024: Neurology
https://read.qxmd.com/read/38457578/unconsciousness-as-the-main-nonfocal-symptom-of-anterior-circulation-transient-ischemic-attack-a-case-report
#30
JOURNAL ARTICLE
Xiaomeng Dong, Ziliang Zhang, Bin Li, Wenbin Ma, Jinbo Chen, Yipeng Su
RATIONALE: Unconsciousness is a nonfocal symptom of transient ischemic attack (TIA) that is frequently observed in patients with vertebrobasilar artery stenosis or occlusion. Conversely, loss of consciousness due to anterior circulation involvement (e.g., middle cerebral artery [MCA]) is a rare occurrence in TIA. PATIENT CONCERNS: This report describes a rare case in a 59-year-old woman who experienced recurrent episodes of altered consciousness because of the occlusion or stenosis of her MCAs...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457555/in-hospital-initiation-of-a-pcsk9-inhibitor-in-patients-with-acute-coronary-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#31
JOURNAL ARTICLE
Wenhai Shi, Yong Xu, Lin Zhou, Wuwan Wang, Wei Huang, Bo Zhou
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to be effective and safe in patients with stable angina and previous myocardial infarction. However, evidence for initiating their use in patients hospitalized with acute coronary syndrome (ACS) is limited. This systematic review and meta-analysis was performed to provide more clinical evidence. METHODS: PubMed, Embase, OVID, Cochrane Library and ClinicalTrials.gov were systematically searched for eligible randomized controlled trials up to March 20, 2023...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456303/thrombolysis-for-wake-up-stroke-versus-non-wake-up-unwitnessed-stroke-eos-individual-patient-data-meta-analysis
#32
JOURNAL ARTICLE
Naruhiko Kamogawa, Kaori Miwa, Kazunori Toyoda, Märit Jensen, Manabu Inoue, Sohei Yoshimura, Mayumi Fukuda-Doi, Takanari Kitazono, Florent Boutitie, Henry Ma, Peter Ringleb, Ona Wu, Lee H Schwamm, Steven Warach, Werner Hacke, Stephen M Davis, Geoffrey A Donnan, Christian Gerloff, Götz Thomalla, Masatoshi Koga
BACKGROUND: Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups. METHODS: Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0...
March 8, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38456149/higher-fibrinogen-and-neutrophil-to-lymphocyte-ratio-are-associated-with-the-early-poor-response-to-intravenous-thrombolysis-in-acute-ischemic-stroke
#33
JOURNAL ARTICLE
Mingzhu Deng, Kangping Song, Yangping Tong, Sufen Chen, Wei Xu, Guohua He, Jue Hu, Hui Xiao, Changmin Wan, Zhen Wang, Fangyi Li
BACKGROUND: Inflammation and platelet activation play pivotal roles in acute ischemic stroke (AIS) pathogenesis. Early response to thrombolysis is a vital indicator for the long-term prognosis of AIS. However, the correlation between fibrinogen or the neutrophil-to-lymphocyte ratio (NLR) and the early response to intravenous thrombolysis in patients with AIS remains unclear. METHODS: AIS patients undergoing intravenous thrombolysis were enrolled between January 2018 and May 2023...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38455102/human-dental-pulp-stem-stromal-cells-in-clinical-practice
#34
EDITORIAL
Mohammed E Grawish
Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical concerns and can be successfully cryopreserved and thawed. The therapeutic effects of DPSCs derived from animal or human sources have been extensively studied through in-vitro and in-vivo animal experiments and the findings indicated that DPSCs are effective not only for dental diseases but also for systemic diseases...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38454606/targeting-lipid-nanoparticles-to-the-blood-brain-barrier-to-ameliorate-acute-ischemic-stroke
#35
JOURNAL ARTICLE
Jia Nong, Patrick M Glassman, Vladimir V Shuvaev, Sahily Reyes-Esteves, Helene C Descamps, Raisa Y Kiseleva, Tyler E Papp, Mohamad-Gabriel Alameh, Ying K Tam, Barbara L Mui, Serena Omo-Lamai, Marco E Zamora, Tea Shuvaeva, Evguenia Arguiri, Xijing Gong, Taylor V Brysgel, Ai Wen Tan, Ashley G Woolfork, Aalim Weljie, Christoph A Thaiss, Jacob W Myerson, Drew Weissman, Scott E Kasner, Hamideh Parhiz, Vladimir R Muzykantov, Jacob S Brenner, Oscar A Marcos-Contreras
Effective delivery of mRNA or small molecule drugs to the brain is a significant challenge in developing treatment for acute ischemic stroke. To address the problem, we have developed targeted nanomedicine to increase drug concentrations in endothelial cells of the blood-brain barrier (BBB) of the injured brain. Inflammation during ischemic stroke causes continuous neuronal death and increase of the infarct volume. To enable targeted delivery to the inflamed BBB, we conjugated lipid nanocarriers with antibodies that bind cell adhesion molecules expressed at the BBB...
March 6, 2024: Molecular Therapy
https://read.qxmd.com/read/38454521/orbital-infarction-syndrome-following-mechanical-thrombectomy-in-internal-carotid-artery-occlusion-a-case-report
#36
JOURNAL ARTICLE
Binh Q Tran, Lanh C Nguyen, Tinh T Trinh, An T T Vo, Minh V Do, Minh Q Tran, Khanh C Tran, Loan H T Tran, Duc T Ha
BACKGROUND: Orbital ischemic syndrome is a rare entity. The clinical signs typically demonstrate acute loss of visual acuity, chemosis, proptosis, ptosis, and total ophthalmoparesis. We report a case of a man who suffered an acute internal carotid artery occlusion and developed orbital ischemic syndrome after a mechanical thrombectomy. CASE PRESENTATION: A 57-year-old Vietnamese (Kinh ethnicity) man was brought to the emergency room with complaints of a speech disturbance, facial palsy, and severe weakness of the left arm and leg, which had started 4 hours earlier, after waking up...
March 8, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38453601/influence-of-intracranial-hemorrhage-on-clinical-outcome-in-acute-vertebrobasilar-artery-occlusion-undergoing-endovascular-treatment
#37
JOURNAL ARTICLE
N Li, M Hong, X Chen, W Sun, Z Chen, L Chen, S Li, H Ge, F Peng
BACKGROUND AND PURPOSE: The effect of intracranial hemorrhage (ICH) on the outcome of patients with large-vessel occlusion undergoing endovascular treatment (EVT) has mainly focused on the anterior circulation. Knowledge of the relationship between ICH and outcomes in patients with acute vertebrobasilar artery occlusion (VBAO) receiving EVT is limited. We aimed to assess whether ICH is a prognostic marker for acute VBAO following EVT. METHODS: Patients who underwent EVT for acute VBAO in the acute posterior circulation ischemic stroke (PERSIST) registry were included...
March 6, 2024: Revue Neurologique
https://read.qxmd.com/read/38453424/gpvi-as-an-effective-antithrombotic-target
#38
JOURNAL ARTICLE
Alexandre Slater, Sophia Khattak, Mark R Thomas
Glycoprotein (GP) VI plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target. The primary role of GPVI on the surface of platelets is a signalling receptor for collagen, which is one of the most potent thrombotic sub-endothelial components that is exposed by atherosclerotic plaque rupture. Inhibition of GPVI has therefore been investigated as a strategy for treatment and prevention of atherothrombosis, such as during stroke and acute coronary syndromes. A range of specific GPVI inhibitors have been characterised and 2 of these inhibitors, glenzocimab and revacept, have completed phase II clinical trials in ischemic stroke...
March 7, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
https://read.qxmd.com/read/38452748/advances-in-prehospital-management-of-intracerebral-hemorrhage
#39
REVIEW
Laura Catherine Gioia, George Nunes Mendes, Alexandre Yves Poppe, Christian Stapf
BACKGROUND: Spontaneous acute intracerebral hemorrhage (ICH) is associated with greater stroke-related disability and mortality. Hematoma expansion (HME), an important treatment target in acute ICH, is time-dependent, with a greater probability of hematoma growth occurring <3 hours from ICH onset. SUMMARY: Promising treatment options to reduce HME include early intensive blood pressure (BP) reduction and the administration of hemostatic or anticoagulant reversal agents, yet large phase III clinical trials have so far failed to show overwhelming benefit for these interventions in acute ICH...
March 7, 2024: Cerebrovascular Diseases
https://read.qxmd.com/read/38450968/time-dependent-systolic-blood-pressure-within-72%C3%A2-h-after-endovascular-treatment-in-large-vessel-occlusion-stroke
#40
JOURNAL ARTICLE
Xin Jiang, Jinghuan Fang, Lijie Gao, Shuju Dong, Jian Wang, Fayun Hu, Li He
BACKGROUND: The association of systolic blood pressure (SBP) and ischemic stroke outcome has recently been proved to be varied at different time points within 72 h after acute ischemic stroke onset; however, the specific status of how SBP affects prognosis at different time points within 72 h after endovascular treatment (EVT) among patients with large vessel occlusion (LVO) remains unclear. METHODS: Consecutive LVO patients treated with EVT were enrolled in our study...
March 2024: Brain and Behavior
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