keyword
https://read.qxmd.com/read/38497517/benefit-of-endovascular-treatment-for-primary-versus-secondary-medium-vessel-occlusion-a-multi-center-experience
#1
JOURNAL ARTICLE
Hai-Zhou Hu, Yong-Gang Zhao, Xin Liu, Xian-Hui Sun, Thanh N Nguyen, Hui-Sheng Chen
AIMS: This study aimed to compare the clinical outcomes and safety of endovascular treatment (EVT) in patients with primary versus secondary medium vessel occlusion (MeVO). METHODS: From the endovascular treatment for acute ischemic stroke in the China registry, we collected consecutive patients with MeVO who received EVT. The primary endpoint was a good outcome, defined as a modified Rankin Scale (mRS) 0 to 2 at 90 days. RESULTS: 154 patients were enrolled in the final analysis, including 74 primary MeVO and 80 secondary MeVO...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38495962/cerebral-infarction-due-to-post-traumatic-cerebral-vasospasm-in-a-12-year-old-female
#2
Daisuke Tanikawa, Yushiro Take, Nobuaki Naito, Akio Teranishi, Hiroki Kurita
Cerebral infarction due to post-traumatic cerebral vasospasm is rare. Although some modalities are recommended to detect post-traumatic cerebral vasospasm, its diagnosis remains controversial and challenging. Therefore, in this report, we will use a case report to highlight challenges and to delineate the characteristics of post-traumatic cerebral vasospasm in pediatric patients, including the diagnostic and treatment options. A 12-year-old female was admitted to our hospital following a motor vehicle collision...
March 2024: Curēus
https://read.qxmd.com/read/38495252/the-association-between-cyp2c19-genetic-polymorphism-and-prognosis-in-patients-receiving-endovascular-therapy
#3
JOURNAL ARTICLE
Wei Li, Xun Yang, Jing Chen, Jian-Wei Zhu, Ling-Huan Zeng, Hai-Hong Long, Zhi Chen, Jun Tang, Xiao-Fang Lan
BACKGROUND: Potentially substantial impacts on the prognosis have been observed in individuals undergoing endovascular treatment due to cytochrome P450 2c19 (C YP2C19 ) polymorphism. In an attempt to improve prognosis and lower the recurrence rate, this study investigated the CYP2C19 polymorphism in acute ischemic stroke patients. MATERIALS AND METHODS: A retrospective analysis was performed on 292 patients with cerebral infarction who had acute endovascular recanalization at the Department of Neurology of Chongqing Hospital of Traditional Chinese Medicine between May 2017 and 2019...
2024: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/38495237/the-pitfalls-of-nihss-time-for-a-new-clinical-acute-stroke-severity-scoring-system-in-the-emergency
#4
JOURNAL ARTICLE
Archita Makharia, Ayush Agarwal, Divyani Garg, Venugopalan Y Vishnu, M V Padma Srivastava
Stroke is the second leading cause of death and a major cause of disability worldwide. Stroke severity scales serve as reliable means to track a patient's neurological deficit, predict outcome, and guide treatment decisions in clinical practice. The National Institute of Health Stroke Scale (NIHSS) was introduced over 30 years ago, marking a significant milestone in the field of stroke. Over the years, there have been notable advancements in acute stroke care. Despite several modifications made to NIHSS, none has yet succeeded in effectively capturing all the complex effects of a stroke...
2024: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/38494461/blood-pressure-targets-after-successful-reperfusion-in-mechanical-thrombectomy-for-acute-ischemic-stroke-an-updated-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#5
JOURNAL ARTICLE
Edgar Paulo da Silva Neto, Lucas Fernandes Ferreira, Ana Luisa Carvalho de Cardozo Hernandez, Eberval Gadelha Figueiredo, João Paulo Mota Telles
BACKGROUND: This study sought to determine whether intensive blood pressure (BP) control for patients with successful reperfusion following acute ischemic stroke (AIS) is beneficial, compared to conventional BP management. METHODS: PubMed, Embase, and Cochrane databases were systematically searched for randomized controlled trials (RCTs) on the subject. The studied outcomes included dependency or death at 90 days (modified Rankin Scale [mRS] 3-6); severe disability at 90 days (mRS 3-5); mortality at 90 days; and symptomatic intracranial hemorrhage...
March 18, 2024: Neurological Sciences
https://read.qxmd.com/read/38493062/temperature-management-in-acute-brain-injury-a-narrative-review
#6
REVIEW
Eva Esther Tejerina Álvarez, José Ángel Lorente Balanza
Temperature management has been used in patients with acute brain injury resulting from different conditions, such as post-cardiac arrest hypoxic-ischaemic insult, acute ischaemic stroke, and severe traumatic brain injury. However, current evidence offers inconsistent and often contradictory results regarding the clinical benefit of this therapeutic strategy on mortality and functional outcomes. Current guidelines have focused mainly on active prevention and treatment of fever, while therapeutic hypothermia (TH) has fallen into disuse, although doubts persist as to its effectiveness according to the method of application and appropriate patient selection...
March 15, 2024: Medicina intensiva
https://read.qxmd.com/read/38489969/fibrinogen-deposition-promotes-neuroinflammation-and-fibrin-derived-%C3%AE-377-395-peptide-ameliorates-neurological-deficits-after-ischemic-stroke
#7
JOURNAL ARTICLE
Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan
BACKGROUND: Fibrin(ogen) deposition in the central nervous system (CNS) contributes to neuropathological injury; however, its role in ischemic stroke is unknown. In this study, we identified fibrinogen as a novel proinflammatory regulator of post-stroke neuroinflammation and revealed the neuro-protection effect of fibrin-derived γ377-395 peptide in stroke. METHODS: Fibrinogen depletion and fibrinogen-derived γ377-395 peptide treatment were performed 2 h after establishing a permanent middle cerebral artery occlusion (pMCAO) model...
March 14, 2024: International Immunopharmacology
https://read.qxmd.com/read/38488379/health-inequity-and-time-from-pediatric-stroke-onset-to-arrival
#8
JOURNAL ARTICLE
Akshat M Pai, Teresa To, Gabrielle A deVeber, Daniel Nichol, Andrea Kassner, Birgit Ertl-Wagner, Mubeen F Rafay, Nomazulu Dlamini
BACKGROUND: Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the association between health inequity and onset-to-arrival in a pediatric comprehensive stroke center. METHODS: A retrospective observational study was conducted on a consecutive cohort of children (>28 days-18 years) diagnosed with acute arterial ischemic stroke (AIS) between 2004 and 2019...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38488357/ctp-defined-large-core-is-a-better-predictor-of-poor-outcome-for-endovascular-treatment-than-aspects-defined-large-core
#9
JOURNAL ARTICLE
Yi Sui, Wenhuo Chen, Chushuang Chen, Yanting Chang, Andrew Bivard, Peng Wang, Yu Geng, Mark Parsons, Longting Lin
BACKGROUND: Recent trials confirmed the effectiveness of endovascular therapy in patients with large ischemic cores. Yet the optimal neuroimaging modalities to define large core remains unclear. We tried to address this question by comparing the functional outcomes in patients receiving thrombectomy selected by either noncontrast computed tomography Alberta Stroke Program Early Computed Tomography Score (ASPECTS) or Computed Tomography perfusion (CTP). METHODS: This study retrospectively selected patients enrolled in the International Stroke Perfusion Registry between August 2011 and April 2022...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38487760/the-effect-of-out-of-hours-admission-on-mortality-in-patients-who-underwent-thrombectomy-due-to-ischemic-stroke
#10
JOURNAL ARTICLE
Kadir Küçükceran, Mustafa Kürşat Ayrancı, Abdullah Sadık Girişgin, Sedat Koçak, Zerrin Defne Dündar, Osman Koç
BACKGROUND: It is important to investigate the factors that may delay the diagnosis and treatment process of ischemic stroke. The aim of this study was to investigate whether in-hospital mortality increased in patients who presented to the emergency department out-of-hours and underwent thrombectomy. METHODS: A total of 59 patients who applied to the emergency department between January 1, 2018 and November 1, 2021 and underwent thrombectomy due to ischemic stroke were included in the study...
March 1, 2024: Journal of Acute Medicine
https://read.qxmd.com/read/38487322/isolated-insular-stroke-topography-is-the-answer-with-respect-to-outcome-and-cardiac-involvement
#11
JOURNAL ARTICLE
Fedra Kuris, Sara Tartaglia, Roberto Sperotto, Laura Ceccarelli, Daniele Bagatto, Simone Lorenzut, Giovanni Merlino, Francesco Janes, Carolina Gentile, Roberto Marinig, Lorenzo Verriello, Mariarosaria Valente, Giada Pauletto
BACKGROUND AND PURPOSE: Isolated insular strokes (IIS) are a rare occurrence due to the frequent concomitant involvement of adjacent territories, supplied by the M2 segment of the middle cerebral artery (MCA), and clinical aspects are sometimes contradictory. We aimed to describe clinical and radiological characteristics of a pure IIS case series, focusing on its functional outcome and cardiac involvement. METHODS: We identified 15 isolated insular ischemic strokes from a pool of 563 ischemic strokes occurred between January 2020 and December 2021...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38487124/a-study-of-factors-affecting-functional-outcomes-in-patients-with-successful-recanalization-by-mechanical-thrombectomy
#12
JOURNAL ARTICLE
Ichiro Deguchi, Takashi Osada, Toru Nakagami, Shinya Kohyama, Shinichi Takahashi
BACKGROUND AND PURPOSE: Reperfusion therapy is typically performed in cases with acute cerebral infarction. Mechanical thrombectomy (MT) achieves superior recanalization and favorable outcomes. However, some patients have poor functional prognosis despite successful recanalization. We investigated factors affecting functional prognosis after MT with good reperfusion. METHODS: Among the 205 consecutive cases with ischemic stroke treated with MT at our center from January 1, 2019 to March 31, 2021, 168 with successful recanalization were included...
February 2024: Curēus
https://read.qxmd.com/read/38484864/the-role-of-dorsolateral-striatum-in-the-effects-of-deep-cerebellar-stimulation-mediated-motor-recovery-following-ischemic-stroke-in-rodents
#13
JOURNAL ARTICLE
Hugh H Chan, Nicole D Mathews, Hemen Khanna, Nymisha Mandava, Olivia Hogue, Andre G Machado, Kenneth B Baker
Despite great advances in acute care and rehabilitation, stroke remains the leading cause of motor impairment in the industrialized world. We have developed a deep brain stimulation (DBS)-based approach for post-stroke rehabilitation that has shown reproducible effects in rodent models and has been recently translated to humans. Mechanisms underlying the rehabilitative effects of this novel therapy have been largely focused on the ipsilesional cortex, including cortical reorganization, synaptogenesis, neurogenesis and greater expression of markers of long-term potentiation...
March 12, 2024: Experimental Neurology
https://read.qxmd.com/read/38483761/atrial-fibrillation-complicating-acute-myocardial-infarction-prevalence-impact-and-management-considerations
#14
REVIEW
Besher Sadat, Haider Al Taii, Muhie Sabayon, Chockalingam A Narayanan
PURPOSE OF REVIEW: Atrial fibrillation (AF) and myocardial infarction (MI) often coexist, and this overlapping nature leads to heightened morbidity and increases the need for comprehensive risk management strategies. The precise trajectory and implications of atrial fibrillation complicating myocardial infarction remain subjects of debate, with divergent reports presenting varying accounts. This review seeks to provide an in-depth exploration of the existing literature to cover the predictors, implication, and available management of new onset atrial fibrillation (NOAF) complicating acute myocardial infarction (AMI)...
March 14, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38482520/recombinant-human-heavy-chain-ferritin-nanoparticles-serve-as-ros-scavengers-for-the-treatment-of-ischemic-stroke
#15
JOURNAL ARTICLE
Mi Qi, Yajuan Cheng, Ke Liu, Jingxing Cai, Tianyu Liu, Xiaoying Wu, Huili Tang, He Huang, Qinbiao Chen, Xiaoguang Zhou
PURPOSE: Ischemic stroke is a high-incidence disease that threatens human well-being. The potent neuroprotective effects render reactive oxygen species (ROS) scavengers potential agents for acute ischemic stroke therapy. Challenges such as inadequate permeability across the blood-brain barrier (BBB), limited half-life, and adverse effects hinder the widespread utilization of small molecule and inorganic ROS scavengers. Thus, there is an urgent demand for efficacious neuroprotective agents targeting ischemic stroke...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38481954/post-event-follow-up-costs-in-patients-with-atherosclerotic-cardiovascular-disease-in-spain
#16
JOURNAL ARTICLE
Icíar Martínez López, Jorge Francisco Gómez Cerezo, José M Gámez, Isabel Egocheaga Cabello, Mar Castellanos, Raquel Campuzano Ruiz, Vivencio Barrios, Vicente Pallarés-Carratalá, José Manuel Rodríguez, Nuria Morant Talamante, Javier Parrondo, José María Mostaza
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is one of the main causes of morbidity and mortality in developed countries and entails high resources use and costs for health systems. The risk of suffering future cardiovascular (CV) events and the consequent resources use is higher in those patients who have already had a previous cardiovascular event. The objective of the study was to determine the average annual cost of patients with a new or recurrent atherosclerotic CV event during the 2 years after the event...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38481899/outcomes-of-mechanical-thrombectomy-in-patients-with-neurological-disorders-a-national-inpatient-sample-database-analysis
#17
JOURNAL ARTICLE
Mohammad El-Ghanem, Hael Abdulrazeq, Leonardo Brasiliense, Hamza Abbad, Pedro Aguilar-Salinas, Fawaz Al-Mufti, Travis Dumont
INTRODUCTION: Mechanical thrombectomy (MT) has changed the standard of care for patients presenting with acute ischemic stroke (AIS). The window of treatment has significantly increased the number of patients who would benefit from intervention and operators may be confronted with patients harboring preexistent neurological disorders. Still, the epidemiology of patients with AIS and neurological disorders has not been established. METHODS: This is a retrospective study, which utilizes data from the National Inpatient Sample (NIS) between 2012 and 2016...
February 2024: Curēus
https://read.qxmd.com/read/38481016/blood-pressure-after-successful-endovascular-therapy-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#18
REVIEW
Khaled Gharaibeh, Nameer Aladamat, Adam T Mierzwa, Rahul Rao, Hisham Alhajala, Sami Al Kasab, Mohammad Anadani, Richard Burgess, Syed Zaidi, Mouhammad Jumaa
OBJECTIVE: There are limited data evaluating the optimum blood pressure (BP) goal post mechanical thrombectomy (MT) and its effect on outcomes of patients with large vessel occlusions (LVO). The objective of this study was to compare the efficacy and safety of intensive versus conventional BP control after reperfusion with MT via a systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: We searched PubMed and Embase to obtain articles related to BP control post MT through September 2023...
March 13, 2024: Annals of Neurology
https://read.qxmd.com/read/38477243/-advisability-of-carotid-endarterectomy-in-asymptomatic-patients
#19
JOURNAL ARTICLE
D A Korshunov, V A Kulbak, A V Chupin
OBJECTIVE: To determine the optimal treatment strategy for patients with asymptomatic carotid stenosis. MATERIAL AND METHODS: The authors reviewed clinical guidelines for the management of patients with asymptomatic carotid stenosis 60-99%, as well as medical studies and meta-analyses comparing carotid endarterectomy and optimal drug therapy in asymptomatic patients between 1993 and 2023. RESULTS: The choice of treatment strategy for patients with asymptomatic carotid artery stenosis is still a controversial issue...
2024: Khirurgiia
https://read.qxmd.com/read/38476422/assessment-of-onset-to-door-time-in-acute-ischemic-stroke-and-factors-associated-with-delay-at-a-tertiary-care-center-in-south-india
#20
JOURNAL ARTICLE
Ashika Anees, Praveen Panicker, Thomas Iype, K R Sreelekha
OBJECTIVES: Intravenous thrombolysis is an effective treatment of acute ischemic stroke but has a narrow therapeutic time window of 3-4.5 h. Pre-hospital delay is a major barrier to patients becoming eligible for thrombolysis. This single-center study assessed the factors causing longer onset-to-door (OTD) time to identify measures that will help decrease the delay. MATERIALS AND METHODS: Patients with acute ischemic stroke presenting to the emergency department from August to October 2022 were included in the study...
2024: Journal of Neurosciences in Rural Practice
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