Tilman Kühn, Nicole Kalotai, Anna M Amini, Julia Haardt, Andreas Lehmann, Annemarie Schmidt, Anette E Buyken, Sarah Egert, Sabine Ellinger, Anja Kroke, Stefan Lorkowski, Sandrine Louis, Matthias B Schulze, Lukas Schwingshackl, Roswitha Siener, Gabriele I Stangl, Bernhard Watzl, Armin Zittermann, Katharina Nimptsch
PURPOSE: It has been proposed that a higher habitual protein intake may increase cancer risk, possibly via upregulated insulin-like growth factor signalling. Since a systematic evaluation of human studies on protein intake and cancer risk based on a standardised assessment of systematic reviews (SRs) is lacking, we carried out an umbrella review of SRs on protein intake in relation to risks of different types of cancer. METHODS: Following a pre-specified protocol (PROSPERO: CRD42018082395), we retrieved SRs on protein intake and cancer risk published before January 22th 2024, and assessed the methodological quality and outcome-specific certainty of the evidence using a modified version of AMSTAR 2 and NutriGrade, respectively...
April 21, 2024: European Journal of Nutrition