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Acute pulmonary edema

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https://www.readbyqxmd.com/read/29451512/-antegrade-and-retrograde-approach-through-the-venous-graft-for-treating-a-chronic-total-occlusion-in-a-patient-with-acute-coronary-syndrome-complicated-by-pulmonary-edema
#1
Francesco Gallo, Matteo Tebaldi, Carlo Tumscitz
Percutaneous treatment of chronic total occlusions (CTO) is one of the major challenges in contemporary interventional cardiology. These lesions are identified in 15% to 30% of all patients referred for coronary angiography. Percutaneous coronary intervention (PCI) of CTOs is technically challenging and requires familiarity with advanced interventional techniques as well as specialty equipment. The choice of strategy and materials is based on clinical features and coronary anatomy; the correct choice is essential to improve the success probability...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29434972/tanshinone-ii-is-a-potent-candidate-for-treatment-of-lipopolysaccharide-induced-acute-lung-injury-in-rat-model
#2
Ling Li, Yong-Gang Zhang, Yu-Fei Tan, Jing-Jing Zhao, Hua-Ru Zhang, Bing Zhao
The present study aimed to investigate the effect of tanshinone II, isolated from Salvia miltiorrhiza Bunge, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. Male Sprague-Dawley rats were divided into three groups: Control, LPS and tanshinone II. Animals in the tanshinone II and LPS groups were administered 10 mg/kg LPS, whereas those in the control group received an equal volume of normal saline. Tanshinone II treatment group were injected with 30 nm/kg tanshinone II at 1 h after LPS administration...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29430450/diagnosis-of-acute-respiratory-distress-syndrome-by-exhaled-breath-analysis
#3
REVIEW
Lieuwe D J Bos
The acute respiratory distress syndrome (ARDS) is a complication of critical illness that is characterized by acute onset, protein rich, pulmonary edema. There is no treatment for ARDS, other than the reduction of additional ventilator induced lung injury. Prediction or earlier recognition of ARDS could result in preventive measurements and might decrease mortality and morbidity. Exhaled breath contains volatile organic compounds (VOCs), a collection of hundreds of small molecules linked to several physiological and pathophysiological processes...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29430449/new-insights-into-the-mechanisms-of-pulmonary-edema-in-acute-lung-injury
#4
REVIEW
Raquel Herrero, Gema Sanchez, Jose Angel Lorente
Appearance of alveolar protein-rich edema is an early event in the development of acute respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant increase in the permeability of the alveolar epithelial barrier, and represents one of the main factors that contribute to the hypoxemia in these patients. Damage of the alveolar epithelium is considered a major mechanism responsible for the increased pulmonary permeability, which results in edema fluid containing high concentrations of extravasated macromolecules in the alveoli...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29426049/-ards-an-update-part-1-epidemiology-pathophysiology-and-diagnosis
#5
Rolf Dembinski, Frank Mielck
The Acute Respiratory Distress Syndrome (ARDS) is defined by hypoxemic respiratory failure caused by inflammatory response within the lung usually requiring invasive mechanical ventilation. Despite more than 50 years of research numerous issues regarding epidemiology, pathophysiology and diagnosis remain unclear until today: Due to rather unspecific clinical diagnostic criteria incidence of ARDS varies considerably in clinical trials with a range from 4 to 79 cases per 100 000 persons per year. Consequently, mortality is also highly variable from about 40 to 60% in severe ARDS...
February 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29407089/basal-functional-status-predicts-one-year-mortality-after-a-heart-failure-hospitalization-in-elderly-patients-the-rica-prospective-study
#6
David Chivite, Francesc Formiga, Xavier Corbella, Alicia Conde-Martel, Óscar Aramburu, Margarita Carrera, Melitón Francisco Dávila, José Pérez-Silvestre, Luis Manzano, Manuel Montero-Pérez-Barquero
BACKGROUND: Dependence for basic activities of the daily living (ADL) relates to adverse outcomes in elderly acute heart failure (AHF) patients. METHODS: We evaluated patients ≥75years admitted because of AHF, divided according to preadmission Barthel Index (BI) category: severe (BI 0-60), moderate (BI 61-90) and slight dependence or independence for basic ADL (BI 91-100). We compared their baseline characteristics and used logistic regression models to determine whether a BI≤60 confers higher one-year mortality risk...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29406471/life-threatening-accidental-intravenous-epinephrine-overdose-in-a-12-year-old-boy
#7
Maya Caroline André, Jürg Hammer
Reports on accidental intravenous epinephrine overdose in children are extremely rare, although medication errors in the management of pediatric anaphylaxis seem to be frequent. We report a case of a 12-year-old boy presenting with a long-lasting skin rash and dyspnea who was incorrectly diagnosed with early anaphylactic shock and was treated with 10-fold the recommended dose administered by the wrong route (intravenous instead of intramuscular). He reacted with acute loss of consciousness and acute cardiorespiratory failure due to arterial hypotension, ischemic heart failure, and severe pulmonary edema...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29400365/sensitivity-and-specificity-of-ultrasound-for-the-diagnosis-of-acute-pulmonary-edema-a-systematic-review-and-meta-analysis
#8
Yan Wang, Zhiyang Shen, Xuefeng Lu, Yanhua Zhen, Huixia Li
AIMS: This study aimed to determine the sensitivity and specificity of ultrasound for the diagnosis of acute pulmonary edema by meta-analysis. MATERIALS AND METHODS: A systematic search was conducted through the following databases: Cochrane, PubMed, EMBASE and Ovid MEDLINE. Prospective cohort and prospective case-control studies that reported sensitivity and specificity of lung ultrasound in diagnosis of acute pulmonary edema were selected. An independent review of citations was carried out for inclusion and data extraction...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29397882/effectiveness-of-rescue-percutaneous-balloon-aortic-valvuloplasty-in-patients-with-severe-aortic-stenosis-and-acute-heart-failure
#9
Marc Eugène, Marina Urena, Jérémie Abtan, José-Luis Carrasco, Walid Ghodbane, Patrick Nataf, Alec Vahanian, Dominique Himbert
The prognosis of patients with cardiogenic shock (CS) or refractory pulmonary edema because of severe aortic stenosis remains poor. The purpose of this study was to assess the outcomes of rescue percutaneous balloon aortic valvuloplasty (PBAV) in the transcatheter aortic valve implantation (TAVI) era. Patients were consecutively included between 2008 and 2016. CS was defined as ≥1 sign of systemic hypoperfusion and need of catecholamines. Refractory pulmonary edema was defined as not controlled by optimal medical treatment...
December 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397306/anti-inflammatory-roles-of-mesenchymal-stromal-cells-during-acute-streptococcus-pneumoniae-pulmonary-infection-in-mice
#10
Takahiro Asami, Makoto Ishii, Ho Namkoong, Kazuma Yagi, Sadatomo Tasaka, Takanori Asakura, Shoji Suzuki, Tetsuro Kamo, Satoshi Okamori, Hirofumi Kamata, Haiyue Zhang, Ahmed E Hegab, Naoki Hasegawa, Tomoko Betsuyaku
BACKGROUND: Pneumonia is the fourth leading cause of death worldwide, and Streptococcus pneumoniae is the most commonly associated pathogen. Increasing evidence suggests that mesenchymal stromal cells (MSCs) have anti-inflammatory roles during innate immune responses such as sepsis. However, little is known about the effect of MSCs on pneumococcal pneumonia. METHODS: Bone marrow-derived macrophages (BMDMs) were stimulated with various ligands in the presence or absence of MSC-conditioned medium...
January 31, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29393375/expression-level-of-12-amino-acid-triggering-receptor-on-myeloid-cells-like-transcript-1-derived-peptide-alleviates-lipopolysaccharide-induced-acute-lung-injury-in-mice
#11
Ruili Shi, Jiancheng Zhang, Zhang Peng, Shiying Yuan, Sumin Gao, Lin Chen, Yin Yuan
Acute lung injury (ALI) is a critical illness with a high morbidity and mortality rate due to severe inflammation in the lungs. The effects and underlying mechanism of the triggering receptor expressed on myeloid cells‑1 (TREM‑1)‑like transcript‑1‑derived peptide (LR12) on ALI remain unclear. The aim of the present study was to determine whether LR12 attenuates lipopolysaccharide (LPS)‑induced ALI and elucidate the mechanism underlying it. Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group...
January 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29386890/phenotyping-copd-exacerbations-using-imaging-and-blood-based-biomarkers
#12
Nawaf M Alotaibi, Virginia Chen, Zsuzsanna Hollander, Cameron J Hague, Darra T Murphy, Jonathon A Leipsic, Mari L DeMarco, J Mark FitzGerald, Bruce M McManus, Raymond T Ng, Don D Sin
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are caused by a variety of different etiologic agents. Our aim was to phenotype COPD exacerbations using imaging (chest X-ray [CXR] and computed tomography [CT]) and to determine the possible role of the blood tests (C-reactive protein [CRP], the N-terminal prohormone brain natriuretic peptide [NT-proBNP]) as diagnostic biomarkers. Materials and methods: Subjects who were hospitalized with a primary diagnosis of AECOPD and who had had CXRs, CT scans, and blood collection for CRP and NT-proBNP were assessed in this study...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29384478/discrimination-between-bycatch-and-other-causes-of-cetacean-and-pinniped-stranding
#13
Yara Bernaldo de Quirós, Meghan Hartwick, David S Rotstein, Michael M Garner, Andrea Bogomolni, William Greer, Misty E Niemeyer, Greg Early, Frederick Wenzel, Michael Moore
The challenge of identifying cause of death in discarded bycaught marine mammals stems from a combination of the non-specific nature of the lesions of drowning, the complex physiologic adaptations unique to breath-holding marine mammals, lack of case histories, and the diverse nature of fishing gear. While no pathognomonic lesions are recognized, signs of acute external entanglement, bulging or reddened eyes, recently ingested gastric contents, pulmonary changes, and decompression-associated gas bubbles have been identified in the condition of peracute underwater entrapment (PUE) syndrome in previous studies of marine mammals...
January 31, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29382659/prognostic-value-of-the-acute-to-chronic-glycemic-ratio-at-admission-in-acute-myocardial-infarction-a-prospective-study
#14
Giancarlo Marenzi, Nicola Cosentino, Valentina Milazzo, Monica De Metrio, Milena Cecere, Susanna Mosca, Mara Rubino, Jeness Campodonico, Marco Moltrasio, Ivana Marana, Marco Grazi, Gianfranco Lauri, Alice Bonomi, Fabrizio Veglia, Roberto Manfrini, Antonio L Bartorelli
OBJECTIVE: Acute hyperglycemia is a powerful predictor of poor prognosis in acute myocardial infarction (AMI), particularly in patients without diabetes. This emphasizes the importance of an acute glycemic rise rather than glycemia level at admission alone. We investigated in AMI whether the combined evaluation of acute and chronic glycemic levels, as compared with admission glycemia alone, may have a better prognostic value. RESEARCH DESIGN AND METHODS: We prospectively measured admission glycemia and estimated average chronic glucose levels (mg/dL) by the following formula: [(28...
January 30, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29374925/-influences-of-ulinastatin-on-acute-lung-injury-and-time-phase-changes-of-coagulation-parameters-in-rats-with-burn-blast-combined-injuries
#15
W Liu, J K Chai
Objective: To explore the influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with severe burn-blast combined injuries. Methods: One hundred and ninety-two Sprague-Dawley rats were divided into pure burn-blast combined injury group, ulinastatin+ burn-blast combined injury group, and sham injury group according to the random number table, with 64 rats in each group. Two groups of rats with combined burn-blast injuries were inflicted with moderate blast injuries with the newly self-made explosive device...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29366758/transcriptomic-profiling-reveals-gene-expression-kinetics-in-patients-with-hypoxia-and-high-altitude-pulmonary-edema
#16
Li Yuhong, Wuren Tana, Bai Zhengzhong, Tang Feng, Ga Qin, Yang Yingzhong, Guan Wei, Wang Yaping, Charles Langelier, Matthew T Rondina, Ri-Li Ge
OBJECTIVE: High altitude pulmonary edema (HAPE) is a life threatening condition occurring in otherwise healthy individuals who rapidly ascend to high altitude. However, the molecular mechanisms of its pathophysiology are not well understood. The objective of this study is to evaluate differential gene expression in patients with HAPE during acute illness and subsequent recovery. METHODS: Twenty-one individuals who ascended to an altitude of 3780 m were studied, including 12 patients who developed HAPE and 9 matched controls without HAPE...
January 20, 2018: Gene
https://www.readbyqxmd.com/read/29364998/usefulness-of-radiological-signs-of-pulmonary-congestion-in-predicting-failed-spontaneous-breathing-trials
#17
Ana Carolina Peçanha Antonio, Cassiano Teixeira, Priscylla Souza Castro, Ana Paula Zanardo, Marcelo Basso Gazzana, Marli Knorst
Inspiratory fall in intrathoracic pressure during a spontaneous breathing trial (SBT) may precipitate cardiac dysfunction and acute pulmonary edema. We aimed to determine the relationship between radiological signs of pulmonary congestion prior to an SBT and weaning outcomes. This was a post hoc analysis of a prospective cohort study involving patients in an adult medical-surgical ICU. All enrolled individuals met the eligibility criteria for liberation from mechanical ventilation. Tracheostomized subjects were excluded...
July 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29362281/-takotsubo-cardiomyopathy-and-neurogenic-pulmonary-edema-following-fibrinolytic-therapy-for-embolic-stroke-a-case-report
#18
Takehiro Kitagawa, Junkoh Yamamoto, Makoto Kureshima, Hitoshi Maeda, Shigeru Nishizawa
A 79-year-old man presented with left hemiparesis and disturbance of consciousness. Brain magnetic resonance(MR)imaging revealed an infarction in the right insular cortex. MR angiography showed a defect in the inferior trunk of the right middle cerebral artery. The patient was treated with alteplase about 2.5 h after onset. Immediately after the intravenous alteplase administration, the hemiparesis improved. However, his respiratory condition unexpectedly worsened 10 h after onset. Chest radiography demonstrated an infiltrative shadow in both lung fields...
January 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29357510/gbt1118-a-compound-that-increases-the-oxygen-affinity-of-hemoglobin-improves-survival-in-murine-hypoxic-acute-lung-injury
#19
Nathan D Putz, Ciara M Shaver, Kobina Dufu, Chien-Ming Li, Qing Xu, Athiwat Hutchaleelaha, Josh Lehrer-Graiwer, Susan M Majka, Lorraine B Ware, Julie A Bastarache
BACKGROUND: Acute respiratory distress syndrome (ARDS) is characterized by lung inflammation and pulmonary edema leading to arterial hypoxemia and death if the hypoxemia is severe. Strategies to correct hypoxemia have the potential to improve clinical outcomes in ARDS. The goal of this study was to evaluate the potential of hemoglobin modification as a novel therapy for ARDS-induced hypoxemia. METHODS: The therapeutic effect of two different doses of GBT1118, a compound that increases the oxygen affinity of hemoglobin was evaluated in a murine model of acute lung injury induced by intra-tracheal LPS instillation 24 hours prior to exposure to 5% or 10% hypoxia...
December 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29345368/therapeutic-effect-of-lipoxin-a4-%C3%A2-in-malaria-induced-acute-lung-injury
#20
Tatiana A Pádua, Natalia D Torres, André L P Candéa, Maria Fernanda Souza Costa, Johnatas D Silva, João Luiz Silva-Filho, Fabio T M Costa, Patricia R M Rocco, Mariana C Souza, Maria G Henriques
Acute lung injury (ALI) models are characterized by neutrophil accumulation, tissue damage, alteration of the alveolar capillary membrane, and physiological dysfunction. Lipoxin A4  (LXA4 ) is an anti-inflammatory eicosanoid that was demonstrated to attenuate lipopolysaccharide-induced ALI. Experimental models of severe malaria can be associated with lung injury. However, to date, a putative effect of LXA4  on malaria (M)-induced ALI has not been addressed. In this study, we evaluated whether LXA4 exerts an effect on M-ALI...
January 3, 2018: Journal of Leukocyte Biology
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