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Acute pulmonary edema

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https://www.readbyqxmd.com/read/29040215/role-of-receptor-for-advanced-glycation-end-products-in-regulating-lung-fluid-balance-in-lipopolysaccharide-induced-acute-lung-injury-and-infection-related-acute-respiratory-distress-syndrome
#1
Hao Wang, Tao Wang, Zhicheng Yuan, Yufang Cao, Yongfang Zhou, Junyun He, Yongchun Shen, Ni Zeng, Luqi Dai, Fuqiang Wen, Lei Chen
Receptor for advanced glycation end products (RAGE) is implicated in inflammatory responses in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), but its role in pulmonary edema formation remains unclear, especially in infection-related ARDS mainly caused by pneumonia or sepsis. In this study, we investigated the role of RAGE in alveolar fluid regulation by using RAGE gene knockout (RAGE) mice in a murine ALI model induced by lipopolysaccharide (LPS), and by comparing soluble RAGE (sRAGE) levels in serum and bronchial alveolar lavage fluid (BALF) between ARDS patients and control subjects...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/29034214/pathogenic-cd8-t-cells-cause-increased-levels-of-vegf-a-in-experimental-malaria-associated-acute-respiratory-distress-syndrome-but-therapeutic-vegfr-inhibition-is-not-effective
#2
Thao-Thy Pham, Melissa Verheijen, Leen Vandermosten, Katrien Deroost, Sofie Knoops, Kathleen Van den Eynde, Louis Boon, Chris J Janse, Ghislain Opdenakker, Philippe E Van den Steen
Malaria is a severe disease and kills over 400,000 people each year. Malarial complications are the main cause of death and include cerebral malaria and malaria-associated acute respiratory distress syndrome (MA-ARDS). Despite antimalarial treatment, lethality rates of MA-ARDS are still between 20 and 80%. Patients develop pulmonary edema with hemorrhages and leukocyte extravasation in the lungs. The vascular endothelial growth factor-A (VEGF-A) and the placental growth factor (PlGF) are vascular permeability factors and may be involved in the disruption of the alveolar-capillary membrane, leading to alveolar edema...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29033043/in%C3%A2-vivo-lung-perfusion-rehabilitates-sepsis-induced-lung-injury
#3
J Hunter Mehaffey, Eric J Charles, Sarah Schubert, Morgan Salmon, Ashish K Sharma, Dustin Money, Mark H Stoler, Victor E Laubach, Curtis G Tribble, Mark E Roeser, Irving L Kron
BACKGROUND: Sepsis is the leading cause of lung injury in adults and can lead to acute respiratory distress syndrome (ARDS). Using a novel technique of isolated in vivo lung perfusion (IVLP), we hypothesized that normothermic IVLP will improve oxygenation and compliance in a porcine model of sepsis-induced lung injury. METHODS: Mature adult swine (n = 8) were administered lipopolysaccharide (LPS; 50 μg/kg over 2 hours) via the external jugular vein, followed by sternotomy and central extracorporeal membrane oxygenation (ECMO) cannulation (right atrium to ascending aorta)...
September 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#4
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29024080/randomized-comparison-of-balloon-aortic-valvuloplasty-performed-with-or-without-rapid-cardiac-pacing-the-pacing-versus-no-pacing-pnp-study
#5
Gianni Dall'Ara, Antonio Marzocchi, Nevio Taglieri, Carolina Moretti, Giulio Rodinò, Matteo Chiarabelli, Paolo Bottoni, Cinzia Marrozzini, Maria Rita Sabattini, Maria-Letizia Bacchi-Reggiani, Claudio Rapezzi, Francesco Saia
OBJECTIVES: To compare the effectiveness and safety of balloon aortic valvuloplasty (BAV) performed with or without rapid ventricular pacing (RP). BACKGROUND: BAV technique is poorly standardized. METHODS: One hundred consecutive patients were randomly assigned 1:1 between BAV performed with or without RP. Exclusion criteria were an immediate indication for surgical or transcatheter aortic valve replacement, presentation in cardiogenic shock or pulmonary edema refractory to medical stabilization...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29017959/8-isoprostane-is-an-early-biomarker-for-oxidative-stress-in-chlorine-induced-acute-lung-injury
#6
Linda Elfsmark, Lina Ågren, Christine Akfur, Anders Bucht, Sofia Jonasson
Inhalation of chlorine (Cl2) may cause oxidative acute lung injury (ALI) characterized by pulmonary edema, pneumonitis, and hyperreactive airways. The aim of the study was to identify possible biomarkers for Cl2-induced ALI. Female BALB/c mice were exposed to Cl2 for 15min using two protocols 1) concentration-dependent response (25-200ppm) and 2) time-kinetics (2h-14days post-exposure). Exposure to 50-200ppm Cl2 caused a concentration-dependent inflammatory response with increased expression of IL-1β, IL-6 and CXCL1/KC in bronchoalveolar lavage fluid 2-6h after exposure which was followed by increased lung permeability and a neutrophilic inflammation 12-24h post-exposure...
October 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28988328/acacetin-attenuates-mice-endotoxin-induced-acute-lung-injury-via-augmentation-of-heme-oxygenase-1-activity
#7
Dongdong Wu, Yanan Wang, Heng Zhang, Minghua Du, Tanshi Li
Acacetin, a natural product, has a wide spectrum of biological activities such as antioxidant properties. In the present study, we examined whether Acacetin has any beneficial role on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and, if so, whether its effect is mediated via heme oxygenase-1 (HO-1), an antioxidant enzyme playing an important role in ALI. Male BALB/c mice were stimulated with LPS intratracheal instillation to induce ALI. Acacetin was administrated 2 h after LPS challenge. Samples were harvested 10 h after LPS administration...
October 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28982733/atp-catabolism-by-tissue-non-specific-alkaline-phosphatase-contributes-to-development-of-ards-in-influenza-infected-mice
#8
Parker S Woods, Lauren May Doolittle, Judy M Hickman-Davis, Ian Christopher Davis
Influenza A viruses are highly contagious respiratory pathogens that are responsible for significant morbidity and mortality worldwide on an annual basis. We have shown previously that influenza infection of mice leads to increased ATP and adenosine accumulation in the airway lumen. Moreover, we demonstrated that A1-adenosine receptor activation contributes significantly to influenza-induced acute respiratory distress syndrome (ARDS). However, we found that development of ARDS in influenza-infected mice does not require catabolism of ATP to adenosine by ecto-5'-nucleotidase (CD73)...
October 5, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28982177/adipose-derived-stem-cells-attenuate-pulmonary-microvascular-hyperpermeability-after-smoke-inhalation
#9
Koji Ihara, Satoshi Fukuda, Baigalmaa Enkhtaivan, Raul Trujillo, Dannelys Perez-Bello, Christina Nelson, Anita Randolph, Suzan Alharbi, Hira Hanif, David Herndon, Donald Prough, Perenlei Enkhbaatar
BACKGROUND: Pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS). Smoke inhalation causes ARDS, thus significantly increasing the mortality of burn patients. Adipose-derived stem cells (ASCs) exert potent anti-inflammatory properties. The goal of the present study was to test the safety and ecfficacy of ASCs, in a well-characterized clinically relevant ovine model of ARDS. METHODS: Female sheep were surgically prepared. ARDS was induced by cooled cotton smoke inhalation...
2017: PloS One
https://www.readbyqxmd.com/read/28972558/treatments-for-pulmonary-ricin-intoxication-current-aspects-and-future-prospects
#10
REVIEW
Yoav Gal, Ohad Mazor, Reut Falach, Anita Sapoznikov, Chanoch Kronman, Tamar Sabo
Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor beans), is one of the most lethal toxins known, particularly if inhaled. Ricin is considered a potential biological threat agent due to its high availability and ease of production. The clinical manifestation of pulmonary ricin intoxication in animal models is closely related to acute respiratory distress syndrome (ARDS), which involves pulmonary proinflammatory cytokine upregulation, massive neutrophil infiltration and severe edema...
October 3, 2017: Toxins
https://www.readbyqxmd.com/read/28971978/activation-of-the-sweet-taste-receptor-t1r3-by-the-artificial-sweetener-sucralose-regulates-the-pulmonary-endothelium
#11
Elizabeth O Harrington, Alexander Vang, Julie Braza, Aparna Shil, Havovi Chichger
A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular permeability. In these settings, loss of barrier integrity is mediated by cell-contact disassembly and actin-remodelling. Studies into molecular mechanisms responsible for improving microvascular barrier function are therefore vital in the development of therapeutic targets for reducing vascular permeability in ARDS. The sweet taste receptor, T1R3 is a GPCR, activated following exposure to sweet molecules, to trigger a gustducin-dependent signal cascade...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28971158/scorpion-related-cardiomyopathy-and-acute-pulmonary-edema-in-a-child-who-is-stung-by-leiurus-abdullahbayrami
#12
Mehmet Dokur, Mustafa Dogan, Ersen Aydin Yagmur
Venom of Leiurus abdullahbayrami (Scorpiones: Buthidae) is an extremely toxic one and it stimulates voltage-gated sodium and potassium channels. In case of a stung by this scorpion; excessive catecholamine release occur and it impairs left ventricle contractility and consequently a heart failure occurs (scorpion sting-related cardiomyopathy). In addition to this cardiac-induced acute pulmonary, edema may occur in severe cases too. An 11-year-old male child who was stung by a scorpion (species: Leiurus abdullahbayrami) consulted to the Emergency Room...
September 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28966363/accidental-selenium-toxicosis-in-lambs
#13
Christina M McKenzie, Ahmad N Al-Dissi
Acute selenium toxicosis occurred in 3-week-old lambs after accidental over-supplementation by intramuscular injection and caused dyspnea, cyanosis, and sudden death. Pathological lesions included myocardial necrosis, skeletal muscle necrosis, pulmonary edema, hydrothorax, and hydropericardium.
October 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28963443/fasudil-alleviates-lps-induced-lung-injury-by-restoring-aquaporin-5-expression-and-inhibiting-inflammation-in-lungs
#14
Jing-Jing Wang, Hui Kong, Jian Xu, Yan-Li Wang, Hong Wang, Wei-Ping Xie
Fasudil, a selective rho kinase (ROCK) inhibitor, has been reported to play a beneficial role in systemic?inflammation?in acute?lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains unclear. Using hematoxylin-and-eosin (HE) staining, immunohistochemistry, enzyme-linked immunosorbent assay, quantitative real time PCR and Western blotting, we found that fasudil attenuated LPS-induced lung injury, decreased lung edema, and suppressed inflammatory responses including leukocyte infiltration and IL-6 production...
September 30, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28962147/naringenin-ameliorates-lps-induced-acute-lung-injury-through-its-anti-oxidative-and-anti-inflammatory-activity-and-by-inhibition-of-the-pi3k-akt-pathway
#15
Minghong Zhao, Chao Li, Fujun Shen, Meijuan Wang, Ning Jia, Chunbin Wang
The aim of the present study was to explore the effect of naringenin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a mouse model, as well as the underlying mechanism. The animals were randomly assigned to four groups: PBS-treated healthy control (Control), LPS-induced ALI (LPS), vehicle-treated ALI (LPS + Vehicle), and naringenin-treated ALI (LPS + Nar) group. Naringenin (100 mg/kg) was administered orally for 4 consecutive days, starting 3 days prior to induction of ALI. The survival rates of mice, lung wet/dry weight ratios, lung injury score, protein levels of bronchoalveolar lavage fluid (BALF), lactate dehydrogenase (LDH) activity in the BALF, lung myeloperoxidase (MPO) activity, the number of infiltrated neutrophils and reactive oxygen species (ROS) levels (H2O2 and malondialdehyde) were assessed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28954201/rhesus-theta-%C3%AE-defensin-1-attenuates-endotoxin-induced-acute-lung-injury-by-inhibiting-proinflammatory-cytokines-and-neutrophil-recruitment
#16
Jordanna G Jayne, Timothy J Bensman, Justin B Schaal, A Young J Park, Elza Kimura, Dat Tran, Michael E Selsted, Paul M Beringer
Acute lung injury (ALI) is a clinical syndrome characterized by acute respiratory failure and is associated with substantial morbidity and mortality. Rhesus theta defensin-1 (RTD-1) is an antimicrobial peptide with immunomodulatory activity. As airway inflammation and neutrophil recruitment and activation are hallmarks of ALI, we evaluated the therapeutic efficacy of RTD-1 in pre-clinical models of the disease. We investigated the effect of RTD-1 on neutrophil chemotaxis and macrophage-driven pulmonary inflammation with human peripheral neutrophils and LPS-stimulated murine alveolar macrophage (MH-S) cells...
September 27, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28953499/cystic-fibrosis-transmembrane-conductance-regulator-potentiation-as-a-therapeutic-strategy-for-pulmonary-edema-a-proof-of-concept-study-in-pigs
#17
Xiaopeng Li, Luis G Vargas Buonfiglio, Ryan J Adam, David A Stoltz, Joseph Zabner, Alejandro P Comellas
OBJECTIVES: To determine the feasibility of using a cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770/Kalydeco, Vertex Pharmaceuticals, Boston, MA), as a therapeutic strategy for treating pulmonary edema. DESIGN: Prospective laboratory animal investigation. SETTING: Animal research laboratory. SUBJECTS: Newborn and 3 days to 1 week old pigs. INTERVENTIONS: Hydrostatic pulmonary edema was induced in pigs by acute volume overload...
September 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28952011/non-invasive-ventilation-in-acute-cardiogenic-pulmonary-edema-how-to-do-it
#18
Tommaso Maraffi, Anna Maria Brambilla, Roberto Cosentini
No abstract text is available yet for this article.
September 26, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28941533/pathophysiology-and-management-of-acute-respiratory-distress-syndrome-in-children
#19
REVIEW
Sabrina M Heidemann, Alison Nair, Yonca Bulut, Anil Sapru
Acute respiratory distress syndrome (ARDS) is a syndrome of noncardiogenic pulmonary edema and hypoxia that accompanies up to 30% of deaths in pediatric intensive care units. Pediatric ARDS (PARDS) is diagnosed by the presence of hypoxia, defined by oxygenation index or Pao2/Fio2 ratio cutoffs, and new chest infiltrate occurring within 7 days of a known insult. Hallmarks of ARDS include hypoxemia and decreased lung compliance, increased work of breathing, and impaired gas exchange. Mortality is often accompanied by multiple organ failure...
October 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28936958/-application-of-lung-ultrasound-examination-in-severe-high-altitude-pulmonary-edema
#20
Dehua Ma, Haiyong Bao, Hong Zhang, Haixia Shi, Chengrong Li, Wantai Li, Shengnian Zhong, Mei Liu, Ming Hou
OBJECTIVE: To investigate the application value of lung ultrasonic on severe high altitude pulmonary edema. METHODS: A prospective, single-blind, case-control study was conducted. Sixty patients with severe high altitude pulmonary edema admitted to Qinghai University Affiliated Hospital from February 2015 to May 2017 were enrolled. The patients were divided into 2 500-3 000 m group, 3 000-3 500 m group and 3 500-4 200 m group according to different altitudes,with 20 patients in each group...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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