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https://www.readbyqxmd.com/read/28332704/risk-of-discontinuation-of-antipsychotic-long-acting-injections-vs-oral-antipsychotics-in-real-life-prescribing-practice-a-community-based-study
#1
H Verdoux, E Pambrun, M Tournier, J Bezin, A Pariente
OBJECTIVE: To compare the risk of discontinuation of ambulatory antipsychotic treatment in persons treated with antipsychotic long-acting injections (LAIs) or by oral antipsychotics (OAPs). METHODS: The study was performed in a representative sample of persons newly treated with OAPs (n = 6904) affiliated to the French Insurance Healthcare system. The risk of all-cause discontinuation was compared in patients prescribed OAPs (n = 246) vs. matched patients prescribed LAIs (n = 246) using multivariate survival analyses...
March 23, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28324143/rapid-customised-operon-assembly-by-yeast-recombinational-cloning
#2
Michael A Liu, Johanna J Kenyon, Jason Lee, Peter R Reeves
We have developed a system called the Operon Assembly Protocol (OAP), which takes advantage of the homologous recombination DNA repair pathway in Saccharomyces cerevisiae to assemble full-length operons from a series of overlapping PCR products into a specially engineered yeast-Escherichia coli shuttle vector. This flexible, streamlined system can be used to assemble several operon clones simultaneously, and each clone can be expressed in the same E. coli tester strain to facilitate direct functional comparisons...
March 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28192989/in-situ-electrochemical-afm-and-cluster-ion-profiled-xps-characterization-of-an-insulating-polymeric-membrane-as-a-substrate-for-immobilizing-biomolecules
#3
Maria E E Carbone, James E Castle, Rosanna Ciriello, Anna M Salvi, Jon Treacy, Peter Zhdan
The electrochemical oxidation of ortho-aminophenol (oAP) by cyclic voltammetry (CV), on platinum substrates in neutral solution, produces a polymeric film (PoAP) that grows to a limiting thickness of about 10 nm. The insulating film has potential use as a bioimmobilizing substrate, with its specificity depending on the orientation of its molecular chains. Prior investigations suggest that the film consists of alternating quinoneimine and oAP units, progressively filling all the platinum sites during the electrosynthesis...
March 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28159806/oscillatory-lower-body-negative-pressure-impairs-working-memory-task-related-functional-hyperemia-in-healthy-volunteers
#4
Sana Merchant, Marvin S Medow, Paul Visintainer, Courtney Terilli, Julian M Stewart
Neurovascular coupling (NVC) describes the link between an increase in task related neural activity and increased cerebral blood flow denoted "functional hyperemia". We previously showed induced cerebral blood flow oscillations suppressed functional hyperemia; conversely functional hyperemia also suppressed cerebral blood flow oscillations. We used lower body negative pressure (OLBNP) oscillations to force oscillations in middle cerebral artery cerebral blood flow velocity (CBFv). Here, we used N-Back testing, an intellectual memory challenge as a neural activation task, to test the hypothesis that OLBNP-induced oscillatory cerebral blood flow (OCBF) can reduce functional hyperemia and NVC produced by a working memory task, and can interfere with working memory...
February 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28139897/oral-antiplatelet-agents-for-the-management-of-acute-coronary-syndromes-a-review-for-nurses-and-allied-healthcare-professionals
#5
REVIEW
Tania Gesheff, Cescelle Barbour
PURPOSE: We review the use of oral antiplatelet (OAP) therapies in acute coronary syndrome (ACS) management for nurse practitioners (NPs), focusing on current guideline recommendations. DATA SOURCES: Treatment guidelines and clinical articles from PubMed. CONCLUSIONS: Guidelines recommend that dual antiplatelet therapy with a P2Y12 inhibitor and aspirin be initiated for ACS management. The P2Y12 inhibitor clopidogrel has established efficacy, but is associated with suboptimal and delayed platelet inhibition and variability in response...
January 31, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28130334/blockade-of-camkii-depresses-conduction-preferentially-in-the-right-ventricular-outflow-tract-and-promotes-ischemic-ventricular-fibrillation-in-the-rabbit-heart
#6
Mark Warren, Katie Joyce Sciuto, Tyson G Taylor, Vivek Garg, Natalia S Torres, Junko Shibayama, Kenneth W Spitzer, Alexey V Zaitsev
Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates the principle ion channels mediating cardiac excitability and conduction, but how this regulation translates to the normal and ischemic heart remains unknown. Diverging results on CaMKII regulation of Na+ channels further prevent predicting how CaMKII activity regulates excitability and conduction in the intact heart. To address this deficiency, we tested the effects of the CaMKII blocker KN-93 (1 and 2.75 μM) and its inactive analog KN92 (2...
January 27, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28122793/real-world-insights-on-the-initiation-and-treatment-duration-of-oral-antiplatelets-in-acute-coronary-syndromes-a-retrospective-cohort-study
#7
Marc J Claeys, Christophe Beauloye, Suzanne Pourbaix, Peter R Sinnaeve
AIMS: This study is a real world, observational study evaluating the treatment persistence of oral antiplatelet (OAP) therapy during a one-year follow-up in patients after an acute coronary syndrome (ACS). METHODS AND RESULTS: Data on diagnosis, comorbidities, follow-up, OAP treatment, reasons, and decision maker for treatment discontinuation in patients who were discharged from a hospital in Belgium after an ACS between 1 July 2012 and 1 June 2013 were collected by cardiologists from 18 centres, up to 360 days from discharge...
January 24, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28027883/role-of-the-h-bond-between-l53-and-t56-for-aquaporin-4-epitope-in-neuromyelitis-optica
#8
Francesco Pisani, Laura Simone, Concetta Domenica Gargano, Manuela De Bellis, Antonio Cibelli, Maria Grazia Mola, Giacomo Catacchio, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Aquaporin-4 (AQP4) is the CNS water channel organized into well-ordered protein aggregates called Orthogonal Arrays of Particles (OAPs). Neuromyelitis Optica (NMO) is an autoimmune disease caused by anti-OAP autoantibodies (AQP4-IgG). Molecular Dynamics (MD) simulations have identified an H-bond between L53 and T56 as the key for AQP4 epitope and therefore of potential interest for drug design in NMO field. In the present study, we have experimentally tested this MD-prediction using the classic mutagenesis approach...
December 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27881527/clinical-factors-associated-with-initiation-of-and-persistence-with-adp-receptor-inhibiting-oral-antiplatelet-treatment-after-acute-coronary-syndrome-a-nationwide-cohort-study-from-finland
#9
Tuire Prami, Houssem Khanfir, Anna Deleskog, Pål Hasvold, Ville Kytö, Eeva Reissell, Juhani Airaksinen
OBJECTIVES: To study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS). DESIGN: Observational, retrospective, cohort study linking real-life patient-level register data. SETTING: Nationwide drug usage study using data of patients with ACS discharged from hospitals in Finland. PARTICIPANTS: The study population consisted of 54 416 patients (aged ≥18 years) following hospital admission for unstable angina pectoris or myocardial infarction during 2009-2013...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27863801/long-acting-injectable-antipsychotics-for-the-prevention-of-relapse-in-patients-with-recent-onset-psychotic-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Taro Kishi, Kazuto Oya, Nakao Iwata
This meta-analysis of randomized controlled trials (RCTs) investigated the advantages of long-acting injectable antipsychotics (LAI-APs) over oral antipsychotics (OAPs) with regard to efficacy and safety for patients with recent-onset psychotic disorders. Effect sizes and 95% confidence intervals (95%CIs) were calculated. We identified five RCTs (1022 patients, mean study duration=18±7.59 months) that compared LAI-APs (paliperidone or risperidone) with OAPs. Pooled LAI-APs did not outperform OAPs in terms of the preventing of relapse (N=3, n=875)...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27843565/systematic-reviews-causes-of-non-adherence-to-p2y12-inhibitors-in-acute-coronary-syndromes-and-response-to-intervention
#11
Nina Johnston, John Weinman, Lucy Ashworth, Peter Smethurst, Jad El Khoury, Clare Moloney
To understand the factors associated with non-adherence to oral antiplatelet (OAP) therapy in acute coronary syndromes (ACS), and where interventions have modified these factors. Linked systematic reviews were undertaken in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines, using CINAHL Plus, MEDLINE, PsycINFO and PubMed databases. The searches were limited to studies available in English and published from 2000 onwards; last run in June 2015. Review 1: factors...
2016: Open Heart
https://www.readbyqxmd.com/read/27835873/proteomic-identification-of-the-oncoprotein-stat3-as-a-target-of-a-novel-skp1-inhibitor
#12
Xin Cheng, Yong-Qiang Liu, Gui-Zhen Wang, Li-Na Yang, Yong-Zhi Lu, Xin-Chun Li, Bo Zhou, Li-Wei Qu, Xiao-Lu Wang, Yong-Xian Cheng, Jinsong Liu, Sheng-Ce Tao, Guang-Biao Zhou
The S phase kinase-associated protein 1 (Skp1), an adaptor protein of the Skp1-Cul1-F-box protein complex, binds the ubiquitin E3 ligase Skp2 and is critical to its biological functions. Targeting of Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation and degradation of Skp2 and mitotic arrest of lung cancer cells. Here, by using a proteome microarray containing 16,368 proteins and a biotinylated 6-OAP, we identified 99 proteins that could bind 6-OAP, with Skp1 and STAT3 sitting at the central position of the 6-OAP interactome...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27512641/remediation-of-copper-contaminated-soil-by-using-different-particle-sizes-of-apatite-a-field-experiment
#13
Jinfeng Xing, Tiantian Hu, Long Cang, Dongmei Zhou
The particle size of apatite is one of the critical factors that influence the adsorption of heavy metals on apatite in the remediation of heavy metal contaminated soils using apatite. However, little research has been done evaluating the impact of different particle sizes of apatite on immobilization remediation of heavy metal polluted soils in field. In this study, the adsorption isothermal experiments of copper on three kinds of apatite was tested, and the field experiment by using different particle sizes apatite [nano-hydroxyapatite (NAP), micro-hydroxyapatite (MAP), ordinary particle apatite (OAP)] at a same dosage of 25...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27499361/safety-and-tolerability-of-long-acting-injectable-versus-oral-antipsychotics-a-meta-analysis-of-randomized-controlled-studies-comparing-the-same-antipsychotics
#14
Fuminari Misawa, Taishiro Kishimoto, Katsuhiko Hagi, John M Kane, Christoph U Correll
OBJECTIVE: We aimed to assess whether long-acting injectable antipsychotics (LAIs), which are initiated in a loading strategy or overlapping with oral antipsychotics (OAPs) and which cannot be stopped immediately, are associated with greater safety/tolerability issues than OAPs. METHOD: Systematic review and meta-analysis of randomized controlled trials (RCTs) comparing LAIs and OAPs, including only LAI-OAP pairs of the same OAP (allowing oral risperidone and paliperidone as comparators for either risperidone or paliperidone LAI)...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27474744/accumulation-of-peptidoglycan-o-acetylation-leads-to-altered-cell-wall-biochemistry-and-negatively-impacts-pathogenesis-factors-of-campylobacter-jejuni
#15
Reuben Ha, Emilisa Frirdich, David Sychantha, Jacob Biboy, Michael E Taveirne, Jeremiah G Johnson, Victor J DiRita, Waldemar Vollmer, Anthony J Clarke, Erin C Gaynor
Campylobacter jejuni is a leading cause of bacterial gastroenteritis in the developed world. Despite its prevalence, its mechanisms of pathogenesis are poorly understood. Peptidoglycan (PG) is important for helical shape, colonization, and host-pathogen interactions in C. jejuni Therefore, changes in PG greatly impact the physiology of this organism. O-acetylation of peptidoglycan (OAP) is a bacterial phenomenon proposed to be important for proper cell growth, characterized by acetylation of the C6 hydroxyl group of N-acetylmuramic acid in the PG glycan backbone...
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27401589/inherited-thrombophilia-in-women-with-poor-apl-related-obstetric-history-prevalence-and-outcomes-survey-of-208%C3%A2-cases-from-the-european-registry-on-obstetric-antiphospholipid-syndrome-cohort
#16
Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Enrique Esteve-Valverde, Amelia Ruffatti, Angela Tincani, Elmina Lefkou, Maria Tiziana Bertero, Gerard Espinosa, Emmanuel Coloma, Sara de Carolis, Patrizia Rovere-Querini, Valentina Canti, Elisa Picardo, Micaela Fredi, Arsene Mekinian
AIM: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. METHODS: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. RESULTS: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS)...
August 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27395067/pregnancy-outcome-in-women-with-obstetric-and-thrombotic-antiphospholipid-syndrome-a-retrospective-analysis-and-a-review-of-additional-treatment-in-pregnancy
#17
Karoline Mayer-Pickel, Katharina Eberhard, Uwe Lang, Mila Cervar-Zivkovic
Antiphospholipid syndrome (APS) is associated with pregnancy complications such as recurrent early fetal loss (RFL), fetal death, preeclampsia (PE), and intrauterine growth restriction (obstetric APS/OAPS). Other clinical manifestations are venous and/or arterial thromboses (thrombotic APS/TAPS). The data of 37 pregnancies with OAPS and 37 pregnancies with TAPS were analyzed and compared. Overall, the most frequent APS antibodies (aPl) were LA as well as "triple-positivity"; LA antibodies were significantly more frequent in women with TAPS (67...
July 9, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27184512/-prevalence-and-severity-of-hypertensive-emergencies-and-outbreaks-in-the-hospital-emergency-department-of-chu-timone-at-marseille-follow-up-in-three-months-of-hospitalized-patients
#18
H Guiga, G Sarlon-Bartoli, F Silhol, W Radix, P Michelet, B Vaïsse
GOAL: Evaluation of the prevalence and severity of hypertensive emergencies and crisis in an Emergency Service of Timone hospital in Marseille and follow-up of 3 months of hospitalized emergencies. METHODS: This study was conducted in the Emergency Department between April 1 and June 30, 2015. All patients with BP>180 and/or 110mmHg was recorded and classified in true emergencies (presence of visceral pain) and hypertensive isolated crisis. A phone follow-up patients was organized...
June 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27153579/args-oap-online-analysis-pipeline-for-antibiotic-resistance-genes-detection-from-metagenomic-data-using-an-integrated-structured-arg-database
#19
Ying Yang, Xiaotao Jiang, Benli Chai, Liping Ma, Bing Li, Anni Zhang, James R Cole, James M Tiedje, Tong Zhang
MOTIVATION: Environmental dissemination of antibiotic resistance genes (ARGs) has become an increasing concern for public health. Metagenomics approaches can effectively detect broad profiles of ARGs in environmental samples; however, the detection and subsequent classification of ARG-like sequences are time consuming and have been severe obstacles in employing metagenomic methods. We sought to accelerate quantification of ARGs in metagenomic data from environmental samples. RESULTS: A Structured ARG reference database (SARG) was constructed by integrating ARDB and CARD, the two most commonly used databases...
August 1, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27086079/mortality-risk-associated-with-long-acting-injectable-antipsychotics-a-systematic-review-and-meta-analyses-of-randomized-controlled-trials
#20
Taro Kishi, Shinji Matsunaga, Nakao Iwata
Long-acting injectable (LAI) antipsychotics (LAI-APs) have several advantages over oral medications, but deaths reported in Japan during the early post-marketing phase vigilance period have raised safety concerns. We conducted a series of meta-analyses to assess whether LAI-APs affect the mortality of patients with schizophrenia. Three categorical meta-analyses of randomized controlled trials (RCTs) were performed to compare all-cause death (primary outcome) and death due to suicide: individual and pooled LAI-APs vs placebo, individual and pooled LAI-APs vs oral antipsychotics (OAPs), and head-to-head comparisons of LAI-APs...
November 2016: Schizophrenia Bulletin
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