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Francesco Pisani, Laura Simone, Concetta Domenica Gargano, Manuela De Bellis, Antonio Cibelli, Maria Grazia Mola, Giacomo Catacchio, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Aquaporin-4 (AQP4) is the CNS water channel organized into well-ordered protein aggregates called Orthogonal Arrays of Particles (OAPs). Neuromyelitis Optica (NMO) is an autoimmune disease caused by anti-OAP autoantibodies (AQP4-IgG). Molecular Dynamics (MD) simulations have identified an H-bond between L53 and T56 as the key for AQP4 epitope and therefore of potential interest for drug design in NMO field. In the present study, we have experimentally tested this MD-prediction using the classic mutagenesis approach...
December 24, 2016: Biochimica et Biophysica Acta
Tuire Prami, Houssem Khanfir, Anna Deleskog, Pål Hasvold, Ville Kytö, Eeva Reissell, Juhani Airaksinen
OBJECTIVES: To study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS). DESIGN: Observational, retrospective, cohort study linking real-life patient-level register data. SETTING: Nationwide drug usage study using data of patients with ACS discharged from hospitals in Finland. PARTICIPANTS: The study population consisted of 54 416 patients (aged ≥18 years) following hospital admission for unstable angina pectoris or myocardial infarction during 2009-2013...
November 22, 2016: BMJ Open
Taro Kishi, Kazuto Oya, Nakao Iwata
This meta-analysis of randomized controlled trials (RCTs) investigated the advantages of long-acting injectable antipsychotics (LAI-APs) over oral antipsychotics (OAPs) with regard to efficacy and safety for patients with recent-onset psychotic disorders. Effect sizes and 95% confidence intervals (95%CIs) were calculated. We identified five RCTs (1022 patients, mean study duration=18±7.59 months) that compared LAI-APs (paliperidone or risperidone) with OAPs. Pooled LAI-APs did not outperform OAPs in terms of the preventing of relapse (N=3, n=875)...
December 30, 2016: Psychiatry Research
Nina Johnston, John Weinman, Lucy Ashworth, Peter Smethurst, Jad El Khoury, Clare Moloney
To understand the factors associated with non-adherence to oral antiplatelet (OAP) therapy in acute coronary syndromes (ACS), and where interventions have modified these factors. Linked systematic reviews were undertaken in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines, using CINAHL Plus, MEDLINE, PsycINFO and PubMed databases. The searches were limited to studies available in English and published from 2000 onwards; last run in June 2015. Review 1: factors...
2016: Open Heart
Xin Cheng, Yong-Qiang Liu, Gui-Zhen Wang, Li-Na Yang, Yong-Zhi Lu, Xin-Chun Li, Bo Zhou, Li-Wei Qu, Xiao-Lu Wang, Yong-Xian Cheng, Jinsong Liu, Sheng-Ce Tao, Guang-Biao Zhou
The S phase kinase-associated protein 1 (Skp1), an adaptor protein of the Skp1-Cul1-F-box protein complex, binds the ubiquitin E3 ligase Skp2 and is critical to its biological functions. Targeting of Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation and degradation of Skp2 and mitotic arrest of lung cancer cells. Here, by using a proteome microarray containing 16,368 proteins and a biotinylated 6-OAP, we identified 99 proteins that could bind 6-OAP, with Skp1 and STAT3 sitting at the central position of the 6-OAP interactome...
November 7, 2016: Oncotarget
Jinfeng Xing, Tiantian Hu, Long Cang, Dongmei Zhou
The particle size of apatite is one of the critical factors that influence the adsorption of heavy metals on apatite in the remediation of heavy metal contaminated soils using apatite. However, little research has been done evaluating the impact of different particle sizes of apatite on immobilization remediation of heavy metal polluted soils in field. In this study, the adsorption isothermal experiments of copper on three kinds of apatite was tested, and the field experiment by using different particle sizes apatite [nano-hydroxyapatite (NAP), micro-hydroxyapatite (MAP), ordinary particle apatite (OAP)] at a same dosage of 25...
2016: SpringerPlus
Fuminari Misawa, Taishiro Kishimoto, Katsuhiko Hagi, John M Kane, Christoph U Correll
OBJECTIVE: We aimed to assess whether long-acting injectable antipsychotics (LAIs), which are initiated in a loading strategy or overlapping with oral antipsychotics (OAPs) and which cannot be stopped immediately, are associated with greater safety/tolerability issues than OAPs. METHOD: Systematic review and meta-analysis of randomized controlled trials (RCTs) comparing LAIs and OAPs, including only LAI-OAP pairs of the same OAP (allowing oral risperidone and paliperidone as comparators for either risperidone or paliperidone LAI)...
October 2016: Schizophrenia Research
Reuben Ha, Emilisa Frirdich, David Sychantha, Jacob Biboy, Michael E Taveirne, Jeremiah G Johnson, Victor J DiRita, Waldemar Vollmer, Anthony J Clarke, Erin C Gaynor
Campylobacter jejuni is a leading cause of bacterial gastroenteritis in the developed world. Despite its prevalence, its mechanisms of pathogenesis are poorly understood. Peptidoglycan (PG) is important for helical shape, colonization, and host-pathogen interactions in C. jejuni Therefore, changes in PG greatly impact the physiology of this organism. O-acetylation of peptidoglycan (OAP) is a bacterial phenomenon proposed to be important for proper cell growth, characterized by acetylation of the C6 hydroxyl group of N-acetylmuramic acid in the PG glycan backbone...
October 21, 2016: Journal of Biological Chemistry
Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Enrique Esteve-Valverde, Amelia Ruffatti, Angela Tincani, Elmina Lefkou, Maria Tiziana Bertero, Gerard Espinosa, Emmanuel Coloma, Sara de Carolis, Patrizia Rovere-Querini, Valentina Canti, Elisa Picardo, Micaela Fredi, Arsene Mekinian
AIM: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. METHODS: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. RESULTS: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS)...
August 2016: American Journal of Reproductive Immunology: AJRI
Karoline Mayer-Pickel, Katharina Eberhard, Uwe Lang, Mila Cervar-Zivkovic
Antiphospholipid syndrome (APS) is associated with pregnancy complications such as recurrent early fetal loss (RFL), fetal death, preeclampsia (PE), and intrauterine growth restriction (obstetric APS/OAPS). Other clinical manifestations are venous and/or arterial thromboses (thrombotic APS/TAPS). The data of 37 pregnancies with OAPS and 37 pregnancies with TAPS were analyzed and compared. Overall, the most frequent APS antibodies (aPl) were LA as well as "triple-positivity"; LA antibodies were significantly more frequent in women with TAPS (67...
July 9, 2016: Clinical Reviews in Allergy & Immunology
H Guiga, G Sarlon-Bartoli, F Silhol, W Radix, P Michelet, B Vaïsse
GOAL: Evaluation of the prevalence and severity of hypertensive emergencies and crisis in an Emergency Service of Timone hospital in Marseille and follow-up of 3 months of hospitalized emergencies. METHODS: This study was conducted in the Emergency Department between April 1 and June 30, 2015. All patients with BP>180 and/or 110mmHg was recorded and classified in true emergencies (presence of visceral pain) and hypertensive isolated crisis. A phone follow-up patients was organized...
June 2016: Annales de Cardiologie et D'angéiologie
Ying Yang, Xiaotao Jiang, Benli Chai, Liping Ma, Bing Li, Anni Zhang, James R Cole, James M Tiedje, Tong Zhang
MOTIVATION: Environmental dissemination of antibiotic resistance genes (ARGs) has become an increasing concern for public health. Metagenomics approaches can effectively detect broad profiles of ARGs in environmental samples; however, the detection and subsequent classification of ARG-like sequences are time consuming and have been severe obstacles in employing metagenomic methods. We sought to accelerate quantification of ARGs in metagenomic data from environmental samples. RESULTS: A Structured ARG reference database (SARG) was constructed by integrating ARDB and CARD, the two most commonly used databases...
August 1, 2016: Bioinformatics
Taro Kishi, Shinji Matsunaga, Nakao Iwata
Long-acting injectable (LAI) antipsychotics (LAI-APs) have several advantages over oral medications, but deaths reported in Japan during the early post-marketing phase vigilance period have raised safety concerns. We conducted a series of meta-analyses to assess whether LAI-APs affect the mortality of patients with schizophrenia. Three categorical meta-analyses of randomized controlled trials (RCTs) were performed to compare all-cause death (primary outcome) and death due to suicide: individual and pooled LAI-APs vs placebo, individual and pooled LAI-APs vs oral antipsychotics (OAPs), and head-to-head comparisons of LAI-APs...
November 2016: Schizophrenia Bulletin
S R Windon, S D Jepsen, S D Scheer
Quality of life is a broad concept that presents a challenge to measure as a scientific category. Quality of life encompasses a broad range of variables based on an individual's expression of life satisfaction, perceptions, values, feelings of subjective well-being, and happiness. This study identified and examined factors that influenced the quality of life of Ohio farmers with disabilities who were enrolled in the Ohio AgrAbility Program (OAP) (n = 55) and participated in this study (60% response rate). A 34-item questionnaire was created...
January 2016: Journal of Agricultural Safety and Health
D Batouche, K Elhalimi, N Benatta, N Chaib, S Abas-Sini, Y Touhami, M A Negadi, Z Mentouri
OBJECTIFS: Les indications de prescription des diurétiques sont diverses notamment en milieu de réanimation. Elles peuvent être bien conduites sous réserve d'un monitorage de la volémie. Ce travail, a pour objectif d'évaluer l'utilisation des diurétiques en réanimation au niveau des indications de prescriptions. MéTHODES: Étude monocentrique rétrospective incluant tous les patients hospitalisés en réanimation pédiatrique sur une période de janvier 1997 à décembre 2014, chez qui une prescription des diurétiquesétait indiquée...
December 2015: Annales de Cardiologie et D'angéiologie
D Batouche, N Benatta, K El Halimi, L Sadaoui, M A Negadi, Z Mentouri
OBJECTIFS: Le syndrome de Bardet Biedl (SBB) est une maladie héréditaire rare à transmission autosomique récessive entrainant une atteinte multiviscérale dont l'anomalie rénale reste la plus grave. L'objectif est de décrire la forme clinique de l'hypertension artérielle compliquant une insuffisance rénale chronique en acutisation. MéTHODES: Nous rapportons 3 cas d'enfants hospitalisés dans le service de réanimation pédiatrique, dans un tableau d'insuffisance rénale chronique secondaire à une néphropathie tubulo-interstitielle, compliquée d'une encéphalopathie hypertensive...
December 2015: Annales de Cardiologie et D'angéiologie
N Mtaoua, N B Mefteh, A Sayhi, N Ridene, E Rbia, N B Kahla, A Khelil
OBJECTIFS: La dyspnée est un motif fréquent de consultation aux urgences. Elle pose des difficultés diagnostiques dues à la multiplicité des étiologies, aux atypies sémiologiques et aux difficultés d'interprétation des examens complémentaires, essentiellement chez le sujet âgé. Le but du travail est d'étudier le profil épidémiologique des sujets âgés consultant pour une dyspnée aux urgences, d'énumérer les différentes explorations de première intention à pratiquer, et de préciser les principales étiologies...
December 2015: Annales de Cardiologie et D'angéiologie
M Mekki, N B Mefteh, A Sayhi, N Ridene, M Mtaoua, E Rbia, N B Kahla, A Khelil
OBJECTIFS: La dyspnée est un motif de recours et d'admission fréquent aux urgences. Le type de la dyspnée, son mode de survenue, ses facteurs déclenchant, son caractère (inspiratoire, expiratoire) sont des éléments importants de l'interrogatoire. MéTHODES: Il s'agit d'une étude rétrospective, menée au SAU de l'Hôpital Maamouri de Nabeul, durant une année, incluant tout patient se présentant pour une dyspnée. Celle post-traumatique n'a pas été retenue dans notre série...
December 2015: Annales de Cardiologie et D'angéiologie
D Batouche, K Elhalimi, N Benatta, L Sadaoui, S Zohret, N Boucherit, M Berexi-Reguig, F Benhamed, M Negadi, Z Mentouri
OBJECTIFS: L'hypertension artérielle maligne (HTAm), affection rare en pédiatrie, est particulière par sa présentation clinique qui est souvent trompeuse et par ses étiologies. Nous décrivons l'aspect clinique et étiologique de HTAm. MéTHODES: Étude rétrospective des dossiers d'enfants admis durant 20 ans en réanimation pédiatrique où nous avons relevé les cas ayant présenté une HTAm. RéSULTATS: 66 patients ont été inclus soit une prévalence de 0,6 %. L'âge des patients varie de 12 mois à 16 ans...
December 2015: Annales de Cardiologie et D'angéiologie
H Guiga, G Sarlon Bartoli, F Silhol, W Radix, B Vaïsse
OBJECTIFS: Étudier la prévalence et la gravité des urgences et des poussées hypertensives dans un Service d'Urgence Hospitalière de CHU, et effectuer un suivi à 3 mois des patients hospitalisés. MéTHODES: Cette étude prospective a été réalisée dans le Service des Urgences entre le 1(er)(a)vril et le 31 juin 2015 : tous les patients avec une PA > 180 et/ou 110mmHg ont été comptabilisés et classés en urgences vraies (présence d'une souffrance viscérale) et en poussées hypertensives isolées...
December 2015: Annales de Cardiologie et D'angéiologie
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