keyword
MENU ▼
Read by QxMD icon Read
search

therapy for achille

keyword
https://www.readbyqxmd.com/read/27874307/single-center-single-dose-open-label-randomized-two-period-crossover-study-on-the-bioavailability-of-methotrexate-administered-using-a-novel-prefilled-needle-free-delivery-system-zeneo
#1
Boris Bienvenu, Achille Aouba, Jacques-Eric Gottenberg, Celine Verstuyft
OBJECTIVE: ZENEO (Crossject, Chenôve, France) is a needle-free injection device. We performed a pharmacokinetic study to investigate the bioequivalence of methotrexate administered subcutaneously using either ZENEO or a conventional needle and syringe. RESEARCH DESIGN AND METHODS: This was a single-dose, open-label, laboratory-blind, randomized crossover study performed in adult healthy volunteers. Each participant received two methotrexate injections (each 25 mg), one via ZENEO and one via conventional injection, with a 21-28 day wash-out interval between dosing...
November 22, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27843949/low-energy-extracorporeal-shock-wave-therapy-in-the-treatment-of-chronic-insertional-achilles-tendinopathy-a-case-series
#2
Vito Pavone, Luca Cannavò, Antonio Di Stefano, Gianluca Testa, Luciano Costarella, Giuseppe Sessa
Introduction. We report the results of a series of 40 patients with chronic insertional Achilles tendinopathy treated with low-energy ESWT after the failure of a 3-month program of eccentric exercises alone. Methods and Materials. 40 patients, 28 (70%) males and 12 (30%) females, were treated between January and December 2014. All patients were previously treated with only eccentric exercises for a 3-month period. The treatment protocol included 4 sessions of ESWT with a 2-week interval, from 800 shots in each one (4 Hz, 14 KeV), together with eccentric exercises...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27825462/targeting-cell-adhesion-and-homing-as-strategy-to-cure-waldenstr%C3%A3-m-s-macroglobulinemia
#3
REVIEW
Steven T Pals, Marie José Kersten, Marcel Spaargaren
Most B-cell malignancies strictly depend on signals from the microenvironment for their survival and proliferation. This niche-dependency can be regarded as their Achilles' heel and provides an excellent target for therapy. Waldenström's macroglobulinemia (WM) is characterized by the accumulation of neoplastic post-germinal center B cells within the bone marrow (BM). Interestingly, one third of the patients carry activating mutations in the chemokine receptor CXCR4, a key mediator of B cell and plasma cell homing to the BM...
June 2016: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/27824237/focused-extracorporeal-shock-wave-therapy-combined-with-supervised-eccentric-training-for-supraspinatus-calcific-tendinopathy
#4
Ettore Carlisi, Claudio Lisi, Anna Dall'angelo, Serena Monteleone, Vincenza Nola, Carmine Tinelli, Elena Dalla Toffola
BACKGROUND: Extracorporeal shock wave therapy is effective in reducing shoulder pain and improving function in calcific supraspinatus tendinopathy. Eccentric exercise has been introduced as an effective treatment choice for Achilles tendinopathy, but poor evidence exists about its role in the treatment of rotator cuff tendinopathy. AIM: To investigate if adding a supervised eccentric training of the shoulder abductor muscles could improve the outcome of extracorporeal shock wave therapy...
November 8, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27815858/a-retrospective-study-of-azacitidine-treatment-in-patients-with-intermediate-2-or-high-risk-myelodysplastic-syndromes-in-a-real-world-clinical-setting-in-greece
#5
Vasiliki Pappa, Achilles Anagnostopoulos, Eleni Bouronikou, Evangelos Briasoulis, Ioannis Kotsianidis, Maria Pagoni, Panagiotis Zikos, Konstantinos Tsionos, Nora Viniou, John Meletis, Helen Papadaki, Anna Kioumi, Athanasios Galanopoulos, Elisavet-Christine Vervessou, Elias Poulakidas, Panagiotis Karmas, Kiki Karvounis, Argiris Symeonidis
For patients with intermediate-2 or high risk [according to the International Prognostic Scoring System (IPSS)] myelodysplastic syndromes (MDS), azacitidine treatment offers hematologic improvement (HI) but also has the potential to modify the natural disease course. 'RETRO-AZA-MDS-001', a retrospective chart review study was conducted from February to November 2012 across 17 hematology hospital sites of Greece, aiming to evaluate the clinical efficacy and safety profile of azacitidine in IPSS intermediate-2/high risk adult MDS patients in routine care...
November 4, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27790051/astym-therapy-improves-bilateral-hamstring-flexibility-and-achilles-tendinopathy-in-a-child-with-cerebral-palsy-a-retrospective-case-report
#6
Nicole A Scheer, Lucas R Alstat, Robert S Van Zant
PURPOSE: The purpose of this case report was to describe the use of Astym therapy to improve hamstring flexibility and Achilles tendinopathy in a child with cerebral palsy. CASE DESCRIPTION: An eight-year-old female with cerebral palsy was referred to physical therapy for the treatment of bilateral hamstring inflexibility and Achilles tendinopathy. Treatment focused on an Astym therapy protocol of eccentric exercise, stretching, active and passive range of motion, gait training, and a home exercise program...
2016: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/27781373/home-hemodialysis-associated-infection-the-achilles-heel-of-intensive-hemodialysis
#7
REVIEW
Clara K Poon, Christopher T Chan
Home hemodialysis (HHD) is emerging as an important alternate renal replacement therapy. Although there are multiple clinical advantages with HHD, concerns surrounding increased risks of infection in this group of patients remain a major barrier to its implementation. In contrast to conventional hemodialysis, infection related complication represents the major morbidity in this mode of renal replacement therapy. Vascular access related infection is an important cause of infection in this population. Use of central vein catheters and buttonhole cannulation in HHD are important modifiable risk factors for HHD associated infection...
October 25, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27765520/initial-treatment-of-congenital-idiopathic-clubfoot-prognostic-factors
#8
S El Batti, F Solla, J-L Clément, O Rosello, I Oborocianu, E Chau, V Rampal
BACKGROUND: The initial treatment of congenital idiopathic clubfoot (CIC) is nonoperative. Either the French physiotherapy method or the Ponseti casting method may be used. Whether either method is superior over the other remains unclear. However, the method used initially is not the only determinant of the final outcome. OBJECTIVE: The primary objective was to identify determinants of the final outcome as evaluated based on the need for surgical treatment and on the Ghanem-Seringe score...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27763655/periodontal-ligament-cells-as-alternative-source-for-cell-based-therapy-of-tendon-injuries-in-vivo-study-of-full-size-achilles-tendon-defect-in-a-rat-model
#9
C-F Hsieh, P Alberton, E Loffredo-Verde, E Volkmer, M Pietschmann, P E Müller, M Schieker, D Docheva
Tendon's natural healing potential is extremely low and inefficient, with significant dysfunction and disability due to hypocellularity and hypovascularity of tendon tissues. The application of stem cells can aid in significantly enhanced repair of tendon rupture; therefore, the main aim of this study is to assess the potential of using periodontal ligament cells (PDL), usually obtained from patients undergoing orthodontic treatment, as a novel cell source for cell-based therapy for tendon injuries in a clinically relevant rat full-size Achilles tendon defect...
October 20, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27723374/comparison-of-clinical-efficacy-among-endoscopy-assisted-radio-frequency-ablation-extracorporeal-shockwaves-and-eccentric-exercises-in-treatment-of-insertional-achilles-tendinosis
#10
Min Wei, Yujie Liu, Zhongli Li, Zhigang Wang
BACKGROUND: We sought to compare clinical efficacy among endoscopy-assisted radio-frequency ablation under local anesthesia, extracorporeal shockwaves (ESWs), and eccentric exercises in treating insertional Achilles tendinosis. METHODS: In this retrospective study, 78 patients diagnosed as having unilateral insertional Achilles tendinosis were enrolled. These participants underwent endoscopy-assisted radio-frequency ablation, ESWs, and eccentric calf muscle exercises between March 1, 2006, and February 28, 2011...
October 10, 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27722560/overcoming-the-achilles-heel-of-photodynamic-therapy
#11
REVIEW
Wenpei Fan, Peng Huang, Xiaoyuan Chen
Photodynamic therapy (PDT) has been applied to treat a wide range of medical conditions, including wet age-related macular degeneration psoriasis, atherosclerosis, viral infection and malignant cancers. However, the tissue penetration limitation of excitation light hinders the widespread clinical use of PDT. To overcome this "Achilles' heel", deep PDT, a novel type of phototherapy, has been developed for the efficient treatment of deep-seated diseases. Based on the different excitation sources, including near-infrared (NIR) light, X-ray radiation, and internal self-luminescence, a series of deep PDT techniques have been explored to demonstrate the advantages of deep cancer therapy over conventional PDT excited by ultraviolet-visible (UV-Vis) light...
November 21, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27716798/microneurotrophins-improve-survival-in-motor-neuron-astrocyte-co-cultures-but-do-not-improve-disease-phenotypes-in-a-mutant-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#12
Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3-5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan by a few months, thus highlighting the need for new and improved therapies. Neurotrophic factors (NTFs) are important for neuronal development, maintenance, and survival. NTF treatment has previously shown efficacy in pre-clinical ALS models...
2016: PloS One
https://www.readbyqxmd.com/read/27701126/management-of-open-distal-lower-extremity-wounds-with-exposed-tendons-using-porcine-urinary-bladder-matrix
#13
Scott E Geiger, Olivier A Deigni, John Tracy Watson, Bruce A Kraemer
: Open wounds of the distal third of the leg and foot with an exposed tendon present a challenge in wound management and in attaining stable, durable coverage. The mobility of the tendon often leads to chronic inflammation that impedes wound closure, while the desiccation of the exposed tendon leads to progressive tendon necrosis. For the authors' cases, the ability of extracellular matrix (ECM) products to modulate wound bed inflammation and facilitate constructive remodeling of a wound seemed a reasonable approach in treating these wounds, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures...
September 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27698099/bcl2-inhibition-by-venetoclax-targeting-the-achilles-heel-of-the-acute-myeloid-leukemia-stem-cell
#14
Vinod A Pullarkat, Edward M Newman
Venetoclax is an oral drug with an excellent side-effect profile that has the potential to revolutionize acute myeloid leukemia (AML) therapy in two areas. Venetoclax-based combination therapies could be a bridge to hematopoietic cell transplant with curative intent for patients with refractory/relapsed AML, and venetoclax-based therapy could provide meaningful survival prolongation for older patients with AML who are not candidates for more aggressive therapies. Cancer Discov; 6(10); 1082-3. ©2016 AACR.See related article by Konopleva and colleagues, p...
October 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27696255/vision-statement-for-multiple-myeloma-future-directions
#15
Kenneth C Anderson
There has been great progress in the management and patient outcome in multiple myeloma due to the use of novel agents including immunomodulatory drugs and proteasome inhibitors; nonetheless, novel agents remain an urgent need. The three promising Achilles heals or vulnerabilities to be targetted in novel therapies include: protein degradation by the ubiquitin proteasome or aggresome pathways; restoring autologous antimyeloma immunity; and targeting aberrant biology resulting from constitutive and ongoing DNA damage in tumour cells...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27639439/comparison-of-peritendinous-hyaluronan-injections-versus-extracorporeal-shock-wave-therapy-in-the-treatment-of-painful-achilles-tendinopathy-a-randomized-clinical-efficacy-and-safety-study
#16
Nils Lynen, Thierry De Vroey, Imke Spiegel, Frederik Van Ongeval, Niels-Jan Hendrickx, Gaëtane Stassijns
OBJECTIVE: To compare the safety and efficacy of hyaluronan (HA) injections with standard extracorporeal shock wave therapy (ESWT) in the treatment of painful midportion Achilles tendinopathy. DESIGN: Multinational, prospective, randomized controlled, blinded-observer trial. SETTING: Ambulatory care. PARTICIPANTS: Adults presenting Achilles midportion tendinopathy for at least 6 weeks and a pain score of at least 40 mm (Huskisson, visual analogue scale (VAS), 100 mm)...
September 14, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27639176/incidence-of-bk-virus-infection-after-kidney-transplantation-is-independent-of-type-of-immunosuppressive-therapy
#17
Josephine Radtke, Nina Dietze, Lutz Fischer, Eike-Gert Achilles, Jun Li, Silke Scheidat, Friedrich Thaiss, Bjoern Nashan, Martina Koch
BACKGROUND: BK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival. METHODS: We retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n=232) or living donation (n=116) between 2008 and 2013. A total of 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor (CNI), and mycophenolic acid (MPA, n=219) or everolimus (n=47); 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n=38) or everolimus (n=44)...
September 17, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27638588/synaptic-failure-the-achilles-tendon-of-sphingolipidoses
#18
Ludovico Cantuti-Castelvetri, Ernesto R Bongarzone
The presence of life-threatening neurological symptoms in more than two-thirds of lysosomal storage diseases (LSDs) underscores how vulnerable the nervous system is to lysosomal failure. Neurological dysfunction in LSDs has historically been attributed to the disruption of neuronal and glial homeostasis resulting from the progressive jamming of the endosomal/lysosomal pathway. In neurons, a dysfunctional endosomal-lysosomal system can elicit dire consequences. Given that neurons are largely postmitotic after birth, one can clearly understand that the inability of these cells to proliferate obliterates any possibility of diluting stored lysosomal material by means of cellular division...
November 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27638530/-hmgb1-as-metabolic-weapon-in-the-arsenal-of-natural-killer-cells
#19
G Gdynia
The German Nobel Prize winner Otto Warburg discovered the importance of glycolysis in cancer cells in the 1920s. Nearly one century later the inhibition of tumor glycolysis in cancer cells could literally be the Achilles Heel in cancer therapy. Surprisingly, we could show that Natural Killer (NK) cells pursue this strategy. They employ specific metabolic weapons to eliminate cancer cells by targeting tumor glycolysis. In colon cancer cells a specifically modified form of high mobility group box 1 (HMGB1) protein released by NK cells induced a previously unknown form of cell death...
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27627685/low-level-laser-therapy-and-cryotherapy-as-mono-and-adjunctive-therapies-for-achilles-tendinopathy-in-rats
#20
Sturla Haslerud, Rodrigo Alvaro Brandão Lopes-Martins, Lúcio Frigo, Jan Magnus Bjordal, Rodrigo Labat Marcos, Ingvill Fjell Naterstad, Liv Heide Magnussen, Jon Joensen
BACKGROUND AND OBJECTIVE: Low-level laser therapy (LLLT) and cryotherapy are widely used treatments in the acute phase of tendon injury. The aim of this study was to investigate the interaction of these two treatments on tendon inflammation and mechanical properties. MATERIALS AND METHODS: Six groups of six Wistar rats were used in this study. The Achilles tendons of the healthy control group were not subjected to injury or treatment. The tendons of the injured nontreated group (ING) were injured, but not treated...
September 14, 2016: Photomedicine and Laser Surgery
keyword
keyword
63520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"