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https://www.readbyqxmd.com/read/29132397/kinase-profiling-of-liposarcomas-using-rnai-and-drug-screening-assays-identified-druggable-targets
#1
Deepika Kanojia, Manoj Garg, Jacqueline Martinez, Anand M T, Samuel B Luty, Ngan B Doan, Jonathan W Said, Charles Forscher, Jeffrey W Tyner, H Phillip Koeffler
BACKGROUND: Liposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic targets. However, very limited knowledge exists of therapeutic critical kinase targets in liposarcoma that could be potentially used in disease management. METHODS: Large RNAi and small-molecule tyrosine kinase inhibitor screens were performed against the proliferative capacity of liposarcoma cell lines of different subtypes...
November 13, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29126330/-management-of-complications-of-pancreatic-anastomoses
#2
Georg F Weber, Axel Schmid, Michael Uder, Robert Grützmann
Background The pancreatic anastomosis may be the Achilles heel in pancreatic surgery. When a postoperative pancreatic fistula develops, be it mild or severe, in some cases life-threatening, POPF-associated complications can occur. Objectives Possibilities for the prophylaxis, diagnosis and therapy of POPF and POPF-associated complications in an interdisciplinary setting. Results Differentiated diagnostic and therapeutic management of POPF grade A - C is supported by recent studies to reduce morbidity and mortality...
November 10, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29095573/severity-and-multiplicity-of-microvascular-complications-are-associated-with-qt-interval-prolongation-in-patients-with-type-2-diabetes
#3
Shunsuke Kobayashi, Mototsugu Nagao, Akira Asai, Izumi Fukuda, Shinichi Oikawa, Hitoshi Sugihara
AIMS/INTRODUCTION: A prolonged QT interval plays a causal role in life-threatening arrhythmia and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes. MATERIALS AND METHODS: Patients with type 2 diabetes (n = 219) admitted to our hospital for glycemic control were enrolled. QT interval was measured manually in lead II on the electrocardiogram and corrected for heart rate using Bazett's formula (QTc)...
November 2, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29078827/insertional-tendinopathy-of-the-achilles-debridement-primary-repair-and-when-to-augment
#4
REVIEW
Rachel J Shakked, Steven M Raikin
Insertional Achilles tendinopathy is a degenerative enthesopathy associated with pain and dysfunction. Nonsurgical management is first attempted for a period of 3 to 6 months and may consist of physical therapy with eccentric training and other modalities. Surgical treatment can be successful with a variety of approaches. A thorough debridement through a midline tendon-splitting approach is associated with high satisfaction rates. Flexor hallucis longus transfer to augment the repair is considered in older, heavier patients or if more than 50% of the tendon was debrided...
December 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/29074337/fluorquinolones-and-the-risk-of-achilles-tendon-disorders-update-on-a-neglected-complication
#5
REVIEW
A L Godoy-Santos, H Bruschini, J Cury, M Srougi, Netto C de Cesar, L F Fonseca, N Maffulli
Fluoroquinolones (FQ) has been considered the first-line therapy for uncomplicated urinary infections. It has been associated with Achilles tendon disorders, especially during the first month of treatment. OBJECTIVE: To evaluate the current evidence and to identify associated risk factors which increase the incidence of this complication. METHODS: Data sources searched included PubMed, MedLine and Scopus from January 1988 to June 2017. RESULTS: A total of 79 articles were used, ciprofloxacin representing the most common drug...
October 23, 2017: Urology
https://www.readbyqxmd.com/read/29054815/whole-brain-radiotherapy-or-autologous-stem-cell-transplantation-as-consolidation-strategies-after-high-dose-methotrexate-based-chemoimmunotherapy-in-patients-with-primary-cns-lymphoma-results-of-the-second-randomisation-of-the-international-extranodal-lymphoma
#6
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested...
October 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29050239/application-of-in-vivo-imaging-techniques-to-monitor-therapeutic-efficiency-of-plx4720-in-an-experimental-model-of-microsatellite-instable-colorectal-cancer
#7
Sarah Rohde, Tobias Lindner, Stefan Polei, Jan Stenzel, Luise Borufka, Sophie Achilles, Eric Hartmann, Falko Lange, Claudia Maletzki, Michael Linnebacher, Änne Glass, Sarah Marie Schwarzenböck, Jens Kurth, Alexander Hohn, Brigitte Vollmar, Bernd Joachim Krause, Robert Jaster
OBJECTIVES: Patient-derived tumor cell lines are a powerful tool to analyze the sensitivity of individual tumors to specific therapies in mice. An essential prerequisite for such an approach are reliable quantitative techniques to monitor tumor progression in vivo. METHODS: We have employed HROC24 cells, grown heterotopically in NMRI Foxn1(nu) mice, as a model of microsatellite instable colorectal cancer to investigate the therapeutic efficiencies of 5'-fluorouracil (5'-FU) and the mutant BRAF inhibitor PLX4720, a vemurafenib analogue, by three independent methods: external measurement by caliper, magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29024514/therapeutic-potential-of-haecs-for-early-achilles-tendon-defect-repair-through-regeneration
#8
Barbara Barboni, Valentina Russo, Valentina Gatta, Nicola Bernabò, Paolo Berardinelli, Annunziata Mauro, Alessandra Martelli, Luca Valbonetti, Aurelio Muttini, Oriana Di Giacinto, Maura Turriani, Antonietta Silini, Giuseppe Calabrese, Michele Abate, Ornella Parolini, Liborio Stuppia, Mauro Mattioli
Cell-based therapy hold great promise for tendon disorders, a widespread debilitating musculoskeletal condition. Even if the cell line remains to be defined, preliminary evidences have proven that amniotic-derived cells possess in vitro and in vivo a great tenogenic potential. The present study investigated the efficacy of transplanted human amniotic epithelial cells (hAECs) by testing their early regenerative properties and mechanisms involved on a validated ovine Achilles tendon partial defect performed on 29 animals...
October 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28992843/-extracorporeal-shock-wave-therapy-in-chronic-achilles-tendinopathy
#9
EDITORIAL
Lotte Hasselbalch, Per Hölmich
Extracorporeal shock wave therapy (ESWT) has shown promising results in treating epicondylitis lateralis humeri and fasciitis plantaris. This study investigates whether the evidence supports ESWT as part of the conservative treatment regime of chronic Achilles tendinopathy. The differences in diagnosing chronic Achilles tendinopathy, the use of different ESWT-machines and the difference in the evaluating methods for pain make it difficult to compare the studies. There is, however, a clear tendency toward ESWT having a positive treatment effect on chronic Achilles tendinopathy at both the insertion and the mid-portion...
October 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28990575/a-systematic-review-of-the-concept-and-clinical-applications-of-bone-marrow-aspirate-concentrate-in-tendon-pathology
#10
Mohamed A Imam, James Holton, Saman Horriat, Ahmed S Negida, Florian Grubhofer, Rohit Gupta, Ali Narvani, Martyn Snow
Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC...
2017: SICOT-J
https://www.readbyqxmd.com/read/28989041/deciphering-molecular-mechanisms-of-arginine-deiminase-based-therapy-comparative-response-analysis-in-paired-human-primary-and-recurrent-glioblastomas
#11
Claudia Maletzki, Yvonne Rosche, Christin Riess, Aline Scholz, Doreen William, Carl Friedrich Classen, Bernd Kreikemeyer, Michael Linnebacher, Tomas Fiedler
Arginine auxotrophy constitutes the Achilles' heel for several tumors, among them glioblastoma multiforme (GBM). Hence, arginine-depleting enzymes such as arginine deiminase (ADI) from Streptococcus pyogenes are promising for treatment of primary and maybe even refractory GBM. Based on our previous study in which ADI-susceptibility was shown on a panel of patient-derived GBM cell lines, we here aimed at deciphering underlying molecular mechanisms of ADI-mediated growth inhibition. We found that ADI (35 mU/mL) initially induces a cellular stress-response that is characterized by upregulation of genes primarily belonging to the heat-shock protein family...
October 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#12
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
October 4, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28978032/vitamin-c-and-doxycycline-a-synthetic-lethal-combination-therapy-targeting-metabolic-flexibility-in-cancer-stem-cells-cscs
#13
Ernestina Marianna De Francesco, Gloria Bonuccelli, Marcello Maggiolini, Federica Sotgia, Michael P Lisanti
Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28954794/the-effectiveness-of-extracorporeal-shockwave-therapy-in-common-lower-limb-conditions-a-systematic-review-including-quantification-of-patient-rated-pain-reduction
#14
REVIEW
Vasileios Korakakis, Rodney Whiteley, Alexander Tzavara, Nikolaos Malliaropoulos
OBJECTIVE: To evaluate extracorporeal shockwave therapy (ESWT) in treating Achilles tendinopathy (AT), greater trochanteric pain syndrome (GTPS), medial tibial stress syndrome (MTSS), patellar tendinopathy (PT) and proximal hamstring tendinopathy (PHT). DESIGN: Systematic review. ELIGIBILITY CRITERIA: Randomised and non-randomised studies assessing ESWT in patients with AT, GTPS, MTSS, PT and PHT were included. Risk of bias and quality of studies were evaluated...
September 27, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28926470/acceptability-and-practicality-of-the-turkish-translation-of-pediatric-gait-arm-legs-and-spine-in-turkish-children
#15
Ezgi Deniz Batu, Özge Keniş Coşkun, Hafize Emine Sönmez, Duygu Karali, Elif Arslanoğlu Aydin, Yelda Bilginer, Evrim Karadağ Saygi, Seza Özen
BACKGROUND: The pediatric Gait, Arms, Leg, and Spine (pGALS) is a practical questionnaire for musculoskeletal (MSK) system evaluation in school-age children. OBJECTIVE: The aim of this study was to evaluate the acceptability/practicality of pGALS Turkish translation in Turkey (cross-sectional study). METHODS: The Turkish translation of pGALS was administered to children (4-18 years) who attended to the Pediatric Emergency Department of Hacettepe University, Ankara, Turkey, and the outpatient clinic of the Physical Therapy and Rehabilitation Department of Marmara University, Istanbul, Turkey, during 1 month in 2016...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28921035/-midportion-achilles-tendinopathy
#16
REVIEW
J Weber, T Buchhorn
Although the incidence of midportion Achilles tendinopathy is under 1% in the general population, it is quite a common disease in runners that is characterized by the symptom triad of pain, swelling and impaired physical performance. Pain and swelling are located in the area 2 to 7 cm proximal the tendon insertion onto the calcaneus.Diagnosis is made by adequate clinical symptoms and corresponding findings in sonography and/or magnetic resonance imaging scans. Histopathologically, mostly degenerative changes in the tendon structure are found, sometimes accompanied by intra- and paratendinous inflammation...
September 18, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28915713/the-reverse-warburg-effect-is-likely-to-be-an-achilles-heel-of-cancer-that-can-be-exploited-for-cancer-therapy
#17
REVIEW
Yaojie Fu, Shanshan Liu, Shanghelin Yin, Weihong Niu, Wei Xiong, Ming Tan, Guiyuan Li, Ming Zhou
Although survival outcomes of cancer patients have been improved dramatically via conventional chemotherapy and targeted therapy over the last decades, there are still some tough clinical challenges that badly needs to be overcome, such as anticancer drug resistance, inevitable recurrences, cancer progression and metastasis. Simultaneously, accumulated evidence demonstrates that aberrant glucose metabolism termed 'the Warburg effect' in cancer cell is closely associated with malignant phenotypes. In 2009, a novel 'two-compartment metabolic coupling' model, also named 'the reverse Warburg effect', was proposed and attracted lots of attention...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901791/determinants-of-1-year-survival-in-critically-ill-acute-leukemia-patients-a-grrr-oh-study
#18
Márcio Tavares, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs...
September 13, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28901376/mechanical-loading-modulates-heterotopic-ossification-in-calcific-tendinopathy-through-the-mtorc1-signaling-pathway
#19
Guorong Chen, Huaji Jiang, Xinggui Tian, Jiajun Tang, Xiaochun Bai, Zhongmin Zhang, Liang Wang
Excessive mechanical loading is a major factor affecting heterotopic ossification (HO), which is a major pathological alteration in calcific tendinopathy. However, physical therapies with mechanical loading as the functional element have exhibited promising results in the treatment of calcific tendinopathy. The dual effects that mechanical loading may have on the pathogenesis and rehabilitation of calcified tendinopathy remain unclear. The present study was designed to investigate the effects of mechanical loading on HO in calcific tendinopathy...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898538/longitudinal-slit-procedure-combined-with-negative-pressure-wound-therapy-for-exposed-achilles-tendons
#20
Tino Wetzig, Diana Kohn
No abstract text is available yet for this article.
September 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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