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https://www.readbyqxmd.com/read/28089985/giant-cell-arteritis-related-stroke-a-retrospective-multicenter-case-control-study
#1
Hubert de Boysson, Eric Liozon, Delphine Larivière, Maxime Samson, Jean-Jacques Parienti, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Kim Ly, Emmanuel Touzé, Bernard Bonnotte, Achille Aouba, Karim Sacré, Boris Bienvenu
OBJECTIVE: Our aim was to describe patients with giant cell arteritis (GCA)-related stroke and to compare them with a control group of GCA patients without stroke. METHODS: We created a retrospective multicenter cohort of patients with (1) GCA diagnosed according to the American College of Rheumatology criteria between 1995 and 2015, and (2) stroke occurring at the time of GCA diagnosis or occurring within 4 weeks of starting GCA therapy. The control group consisted of GCA patients without stroke...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28026734/-callus-distraction-in-the-treatment-of-post-traumatic-defects-of-the-femur-and-tibia
#2
R Veselý, V Procházka
PURPOSE OF THE STUDY Evaluation of the results in patients treated for post-traumatic defects by the method of callus distraction of the femur and tibia using a monolateral external fixator. MATERIAL AND METHODS The group comprised 42 patients, 38 men and 4 woman, who underwent callus distraction using a monolateral external fixator in the Trauma Hospital Brno in the period from 2003 to 2010. The average age of the patients on the day gradual callus distraction was commenced was 32 (18-64) years. Post-traumatic bone defects were treated in 31 patients and deformities resulting from resection of post-traumatic infection loci in 11 patients...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28025559/cancer-s-achilles-heel-apoptosis-and-necroptosis-to-the-rescue
#3
REVIEW
Atreyi Dasgupta, Motonari Nomura, Ryan Shuck, Jason Yustein
Apoptosis, and the more recently discovered necroptosis, are two avenues of programmed cell death. Cancer cells survive by evading these two programs, driven by oncogenes and tumor suppressor genes. While traditional therapy using small molecular inhibitors and chemotherapy are continuously being utilized, a new and exciting approach is actively underway by identifying and using synergistic relationship between driver and rescue genes in a cancer cell. Through these synthetic lethal relationships, we are gaining tremendous insights into tumor vulnerabilities and specific molecular avenues for induction of programmed cell death...
December 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28004000/utility-of-ultrasonography-in-assessing-the-effectiveness-of-extracorporeal-shock-wave-therapy-in-insertional-achilles-tendinopathy
#4
Yi Cheng, Jian Zhang, Yehua Cai
Introduction. The aim of this study was to investigate the utility of ultrasonography (US) for predicting and assessing the effectiveness of extracorporeal shock wave therapy (ESWT) in insertional Achilles tendinopathy (IAT). Methods. A total of 42 patients with an established diagnosis of chronic IAT were examined by US before ESWT and at 4 weeks and 12 weeks after ESWT. The thickness and cross-sectional area (CSA) of the Achilles tendon, size of calcific plaques, tendon structure score, and neovascularization score were measured at each time point...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27993144/disease-status-reasons-for-discontinuation-and-adverse-events-in-1038-italian-children-with-juvenile-idiopathic-arthritis-treated-with-etanercept
#5
Sara Verazza, Sergio Davì, Alessandro Consolaro, Francesca Bovis, Antonella Insalaco, Silvia Magni-Manzoni, Rebecca Nicolai, Denise Pires Marafon, Fabrizio De Benedetti, Valeria Gerloni, Irene Pontikaki, Francesca Rovelli, Rolando Cimaz, Achille Marino, Francesco Zulian, Giorgia Martini, Serena Pastore, Chiara Sandrin, Fabrizia Corona, Marta Torcoletti, Giovanni Conti, Claudia Fede, Patrizia Barone, Marco Cattalini, Elisabetta Cortis, Luciana Breda, Alma Nunzia Olivieri, Adele Civino, Rosanna Podda, Donato Rigante, Francesco La Torre, Gianfranco D'Angelo, Mauro Jorini, Romina Gallizzi, Maria Cristina Maggio, Rita Consolini, Alessandro De Fanti, Valentina Muratore, Maria Giannina Alpigiani, Nicolino Ruperto, Alberto Martini, Angelo Ravelli
BACKGROUND: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). METHODS: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000...
December 20, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27987208/poor-stem-cell-harvest-may-not-always-be-related-to-poor-mobilization-lessons-gained-from-a-mobilization-study-in-patients-with-%C3%AE-thalassemia-major
#6
Varnavas C Constantinou, Asimina Bouinta, Garyfalia Karponi, Fani Zervou, Penelope-Georgia Papayanni, George Stamatoyannopoulos, Achilles Anagnostopoulos, Evangelia Yannaki
BACKGROUND: Hematopoietic stem cell mobilization and leukapheresis in adult patients with β-thalassemia have recently been optimized in the context of clinical trials for obtaining hematopoietic stem cells for thalassemia gene therapy. In some patients, however, the yield of cluster of differentiation 34-positive (CD34+) cells was poor despite successful mobilization, and a modification of apheresis settings was mandatory for harvest rescue. STUDY DESIGN AND METHODS: Data were analyzed from 20 adult patients with β-thalassemia who were enrolled in a clinical trial of optimizing mobilization strategies for stem cell gene therapy...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27926828/harnessing-cancer-cell-metabolism-for-theranostic-applications-using-metabolic-glycoengineering-of-sialic-acid-in-breast-cancer-as-a-pioneering-example
#7
REVIEW
Haitham A Badr, Dina M M AlSadek, Motawa E El-Houseini, Christopher T Saeui, Mohit P Mathew, Kevin J Yarema, Hafiz Ahmed
Abnormal cell surface display of sialic acids - a family of unusual 9-carbon sugars - is widely recognized as distinguishing feature of many types of cancer. Sialoglycans, however, typically cannot be identified with sufficiently high reproducibility and sensitivity to serve as clinically accepted biomarkers and similarly, almost all efforts to exploit cancer-specific differences in sialylation signatures for therapy remain in early stage development. In this report we provide an overview of important facets of glycosylation that contribute to cancer in general with a focus on breast cancer as an example of malignant disease characterized by aberrant sialylation...
February 2017: Biomaterials
https://www.readbyqxmd.com/read/27922288/medial-gastrocnemius-myotendinous-junction-displacement-and-plantar-flexion-strength-in-patients-treated-with-immediate-rehabilitation-after-achilles-tendon-repair
#8
Carlos I De la Fuente, Roberto Peña Y Lillo, Rodrigo Ramirez Campillo, Pablo Ortega-Auriol, Mauricio Delgado, Joel Alvarez-Ruf, Gabriel Carreño
CONTEXT:  Pathologic plantar flexion frequently occurs after operative repair of the Achilles tendon (AT) because of immobilization and non-weight bearing in the first weeks of traditional rehabilitation. Novel rehabilitation strategies that apply mobilization and weight bearing have been proposed, but their effects on medial gastrocnemius myotendinous junction displacement (MJD) and isometric plantar-flexion strength (PFS) are unknown. OBJECTIVE:  To compare the effects of 12 weeks of immediate versus traditional rehabilitation on MJD and PFS in patients with percutaneous AT repair and to compare AT rupture scores (ATRSs) during follow-up...
December 6, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27874307/single-center-single-dose-open-label-randomized-two-period-crossover-study-on-the-bioavailability-of-methotrexate-administered-using-a-novel-prefilled-needle-free-delivery-system-zeneo
#9
Boris Bienvenu, Achille Aouba, Jacques-Eric Gottenberg, Celine Verstuyft
OBJECTIVE: ZENEO (Crossject, Chenôve, France) is a needle-free injection device. We performed a pharmacokinetic study to investigate the bioequivalence of methotrexate administered subcutaneously using either ZENEO or a conventional needle and syringe. RESEARCH DESIGN AND METHODS: This was a single-dose, open-label, laboratory-blind, randomized crossover study performed in adult healthy volunteers. Each participant received two methotrexate injections (each 25 mg), one via ZENEO and one via conventional injection, with a 21-28 day wash-out interval between dosing...
November 22, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27843949/low-energy-extracorporeal-shock-wave-therapy-in-the-treatment-of-chronic-insertional-achilles-tendinopathy-a-case-series
#10
Vito Pavone, Luca Cannavò, Antonio Di Stefano, Gianluca Testa, Luciano Costarella, Giuseppe Sessa
Introduction. We report the results of a series of 40 patients with chronic insertional Achilles tendinopathy treated with low-energy ESWT after the failure of a 3-month program of eccentric exercises alone. Methods and Materials. 40 patients, 28 (70%) males and 12 (30%) females, were treated between January and December 2014. All patients were previously treated with only eccentric exercises for a 3-month period. The treatment protocol included 4 sessions of ESWT with a 2-week interval, from 800 shots in each one (4 Hz, 14 KeV), together with eccentric exercises...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27825462/targeting-cell-adhesion-and-homing-as-strategy-to-cure-waldenstr%C3%A3-m-s-macroglobulinemia
#11
REVIEW
Steven T Pals, Marie José Kersten, Marcel Spaargaren
Most B-cell malignancies strictly depend on signals from the microenvironment for their survival and proliferation. This niche-dependency can be regarded as their Achilles' heel and provides an excellent target for therapy. Waldenström's macroglobulinemia (WM) is characterized by the accumulation of neoplastic post-germinal center B cells within the bone marrow (BM). Interestingly, one third of the patients carry activating mutations in the chemokine receptor CXCR4, a key mediator of B cell and plasma cell homing to the BM...
June 2016: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/27824237/focused-extracorporeal-shock-wave-therapy-combined-with-supervised-eccentric-training-for-supraspinatus-calcific-tendinopathy
#12
Ettore Carlisi, Claudio Lisi, Anna Dall'angelo, Serena Monteleone, Vincenza Nola, Carmine Tinelli, Elena Dalla Toffola
BACKGROUND: Extracorporeal shock wave therapy is effective in reducing shoulder pain and improving function in calcific supraspinatus tendinopathy. Eccentric exercise has been introduced as an effective treatment choice for Achilles tendinopathy, but poor evidence exists about its role in the treatment of rotator cuff tendinopathy. AIM: To investigate if adding a supervised eccentric training of the shoulder abductor muscles could improve the outcome of extracorporeal shock wave therapy...
November 8, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27815858/a-retrospective-study-of-azacitidine-treatment-in-patients-with-intermediate-2-or-high-risk-myelodysplastic-syndromes-in-a-real-world-clinical-setting-in-greece
#13
Vasiliki Pappa, Achilles Anagnostopoulos, Eleni Bouronikou, Evangelos Briasoulis, Ioannis Kotsianidis, Maria Pagoni, Panagiotis Zikos, Konstantinos Tsionos, Nora Viniou, John Meletis, Helen Papadaki, Anna Kioumi, Athanasios Galanopoulos, Elisavet-Christine Vervessou, Elias Poulakidas, Panagiotis Karmas, Kiki Karvounis, Argiris Symeonidis
For patients with intermediate-2 or high risk [according to the International Prognostic Scoring System (IPSS)] myelodysplastic syndromes (MDS), azacitidine treatment offers hematologic improvement (HI) but also has the potential to modify the natural disease course. 'RETRO-AZA-MDS-001', a retrospective chart review study was conducted from February to November 2012 across 17 hematology hospital sites of Greece, aiming to evaluate the clinical efficacy and safety profile of azacitidine in IPSS intermediate-2/high risk adult MDS patients in routine care...
November 4, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27790051/astym-therapy-improves-bilateral-hamstring-flexibility-and-achilles-tendinopathy-in-a-child-with-cerebral-palsy-a-retrospective-case-report
#14
Nicole A Scheer, Lucas R Alstat, Robert S Van Zant
PURPOSE: The purpose of this case report was to describe the use of Astym therapy to improve hamstring flexibility and Achilles tendinopathy in a child with cerebral palsy. CASE DESCRIPTION: An eight-year-old female with cerebral palsy was referred to physical therapy for the treatment of bilateral hamstring inflexibility and Achilles tendinopathy. Treatment focused on an Astym therapy protocol of eccentric exercise, stretching, active and passive range of motion, gait training, and a home exercise program...
2016: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/27781373/home-hemodialysis-associated-infection-the-achilles-heel-of-intensive-hemodialysis
#15
REVIEW
Clara K Poon, Christopher T Chan
Home hemodialysis (HHD) is emerging as an important alternate renal replacement therapy. Although there are multiple clinical advantages with HHD, concerns surrounding increased risks of infection in this group of patients remain a major barrier to its implementation. In contrast to conventional hemodialysis, infection related complication represents the major morbidity in this mode of renal replacement therapy. Vascular access related infection is an important cause of infection in this population. Use of central vein catheters and buttonhole cannulation in HHD are important modifiable risk factors for HHD associated infection...
October 25, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27765520/initial-treatment-of-congenital-idiopathic-clubfoot-prognostic-factors
#16
S El Batti, F Solla, J-L Clément, O Rosello, I Oborocianu, E Chau, V Rampal
BACKGROUND: The initial treatment of congenital idiopathic clubfoot (CIC) is nonoperative. Either the French physiotherapy method or the Ponseti casting method may be used. Whether either method is superior over the other remains unclear. However, the method used initially is not the only determinant of the final outcome. OBJECTIVE: The primary objective was to identify determinants of the final outcome as evaluated based on the need for surgical treatment and on the Ghanem-Seringe score...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27763655/periodontal-ligament-cells-as-alternative-source-for-cell-based-therapy-of-tendon-injuries-in-vivo-study-of-full-size-achilles-tendon-defect-in-a-rat-model
#17
C-F Hsieh, P Alberton, E Loffredo-Verde, E Volkmer, M Pietschmann, P E Müller, M Schieker, D Docheva
Tendon's natural healing potential is extremely low and inefficient, with significant dysfunction and disability due to hypocellularity and hypovascularity of tendon tissues. The application of stem cells can aid in significantly enhanced repair of tendon rupture; therefore, the main aim of this study is to assess the potential of using periodontal ligament cells (PDL), usually obtained from patients undergoing orthodontic treatment, as a novel cell source for cell-based therapy for tendon injuries in a clinically relevant rat full-size Achilles tendon defect...
October 20, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27723374/comparison-of-clinical-efficacy-among-endoscopy-assisted-radio-frequency-ablation-extracorporeal-shockwaves-and-eccentric-exercises-in-treatment-of-insertional-achilles-tendinosis
#18
Min Wei, Yujie Liu, Zhongli Li, Zhigang Wang
BACKGROUND: We sought to compare clinical efficacy among endoscopy-assisted radio-frequency ablation under local anesthesia, extracorporeal shockwaves (ESWs), and eccentric exercises in treating insertional Achilles tendinosis. METHODS: In this retrospective study, 78 patients diagnosed as having unilateral insertional Achilles tendinosis were enrolled. These participants underwent endoscopy-assisted radio-frequency ablation, ESWs, and eccentric calf muscle exercises between March 1, 2006, and February 28, 2011...
October 10, 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27722560/overcoming-the-achilles-heel-of-photodynamic-therapy
#19
REVIEW
Wenpei Fan, Peng Huang, Xiaoyuan Chen
Photodynamic therapy (PDT) has been applied to treat a wide range of medical conditions, including wet age-related macular degeneration psoriasis, atherosclerosis, viral infection and malignant cancers. However, the tissue penetration limitation of excitation light hinders the widespread clinical use of PDT. To overcome this "Achilles' heel", deep PDT, a novel type of phototherapy, has been developed for the efficient treatment of deep-seated diseases. Based on the different excitation sources, including near-infrared (NIR) light, X-ray radiation, and internal self-luminescence, a series of deep PDT techniques have been explored to demonstrate the advantages of deep cancer therapy over conventional PDT excited by ultraviolet-visible (UV-Vis) light...
November 21, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27716798/microneurotrophins-improve-survival-in-motor-neuron-astrocyte-co-cultures-but-do-not-improve-disease-phenotypes-in-a-mutant-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#20
Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3-5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan by a few months, thus highlighting the need for new and improved therapies. Neurotrophic factors (NTFs) are important for neuronal development, maintenance, and survival. NTF treatment has previously shown efficacy in pre-clinical ALS models...
2016: PloS One
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