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https://www.readbyqxmd.com/read/28324932/an-ict-and-mobile-health-integrated-approach-to-optimize-patients-education-on-hypertension-and-its-management-by-physicians-the-patients-optimal-strategy-of-treatment-post-pilot-study
#1
Fabio Albini, Xiaoqiu Liu, Camilla Torlasco, Davide Soranna, Andrea Faini, Renata Ciminaghi, Ada Celsi, Matteo Benedetti, Antonella Zambon, Marco di Rienzo, Gianfranco Parati
INTRODUCTION: Uncontrolled hypertension is largely attributed to unsatisfactory doctor's engagement in its optimal management and to poor patients' compliance to therapeutic interventions. ICT and mobile Health solutions might improve these conditions, being widely available and providing highly effective communication strategies. OBJECTIVE: To evaluate whether ICT and mobile Health tools are able to improve hypertension control by improving doctors' engagement and by increasing patients' education and involvement, and their compliance to lifestyle modification and prescribed drug therapy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324915/alcohol-related-blackouts-negative-alcohol-related-consequences-and-motivations-for-drinking-reported-by-newly-matriculating-transgender-college-students
#2
Larry A Tupler, Daniel Zapp, William DeJong, Maryam Ali, Sarah O'Rourke, John Looney, H Scott Swartzwelder
BACKGROUND: Many transgender college students struggle with identity formation and other emotional, social, and developmental challenges associated with emerging adulthood. A potential maladaptive coping strategy employed by such students is heavy drinking. Prior literature has suggested greater consumption and negative alcohol-related consequences (ARCs) in transgender students compared with their cisgender peers, but little is known about their differing experiences with alcohol-related blackouts (ARBs)...
March 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28324816/sex-differences-and-hormonal-modulation-of-ethanol-enhanced-risk-taking-in-rats
#3
Kathryn G Wallin-Miller, Jordyn Chesley, Juliana Castrillon, Ruth I Wood
BACKGROUND: Ethanol (EtOH) intake correlates with increased risk-taking, and sex differences exist in both EtOH use and risk-taking in humans and rats. However, the interaction of sex and gonadal hormones to affect risk-taking under the influence of EtOH has not been determined. This was the focus of the current study. METHODS: Adult Long-Evans rats (n=18 males and females) were gonadectomized and received hormone replacement at physiologic levels or blank implants (n=7-9/group)...
March 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28324800/breast-textiloma-an-unending-medico-legal-issue-about-a-case-report
#4
Marwa Boussaid, Med Amin Mesrati, Rania Jouirou, Nouha Abdejlil, Abdelfeteh Zakhama, Ali Chadly, Abir Aissaoui
INTRODUCTION: Textiloma is a mass composed of retained surgical textile foreign body. It is a rare iatrogenic complication that can engage the doctor's responsibility. The aim of this manuscript is to report an unusual case of breast Textiloma mimicking a recurrent tumor and to highlight its medico-legal implications. PRESENTATION OF CASE: A 47-year-old lady, without past medical history, was diagnosed with a breast infiltring intraductal carcinoma. She was treated with mastectomy...
March 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28324695/imagining-the-future-the-core-episodic-simulation-network-dissociates-as-a-function-of-timecourse-and-the-amount-of-simulated-information
#5
Preston P Thakral, Roland G Benoit, Daniel L Schacter
Neuroimaging data indicate that episodic memory (i.e., remembering specific past experiences) and episodic simulation (i.e., imagining specific future experiences) are associated with enhanced activity in a common set of neural regions, often referred to as the core network. This network comprises the hippocampus, parahippocampal cortex, lateral and medial parietal cortex, lateral temporal cortex, and medial prefrontal cortex. Evidence for a core network has been taken as support for the idea that episodic memory and episodic simulation are supported by common processes...
February 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28324649/sulfonamides-as-selective-nav1-7-inhibitors-optimizing-potency-pharmacokinetics-and-metabolic-properties-to-obtain-atropisomeric-quinolinone-am-0466-that-affords-robust-in-vivo-activity
#6
Russell F Graceffa, Alessandro A Boezio, Jessica Able, Steven Altmann, Loren M Berry, Christiane M Boezio, John R Butler, Margaret Y Chu-Moyer, Melanie Cooke, Erin F DiMauro, Thomas A Dineen, Elma Feric Bojic, Robert S Foti, Robert T Fremeau, Angel Guzman-Perez, Hua Gao, Hakan Gunaydin, Hongbing Huang, Liyue Huang, Christopher Ilch, Michael Jarosh, Thomas Kornecook, Charles R Kreiman, Daniel S La, Joseph Ligutti, Benjamin Charles Milgram, Min-Hwa Jasmine Lin, Isaac E Marx, Hanh Nho Nguyen, Emily A Peterson, Gwen Rescourio, John Roberts, Laurie B Schenkel, Roman Shimanovich, Brian Andrew Sparling, John Stellwagen, Kristin Taborn, Karina R Vaida, Jean Wang, John T S Yeoman, Violeta L Yu, Dawn Zhu, Bryan D Moyer, Matthew M Weiss
Due to its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demonstrate high levels of selectivity over other NaV isoforms. Herein, we report the discovery and optimization of a novel series of atropisomeric quinolinone sulfonamide inhibitors of NaV1.7, which demonstrate nanomolar inhibition of NaV1.7 and exhibit high levels of selectivity over other sodium channel isoforms...
March 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28324279/soil-organic-matter-as-sole-indicator-of-soil-degradation
#7
S E Obalum, G U Chibuike, S Peth, Y Ouyang
Soil organic matter (SOM) is known to play vital roles in the maintenance and improvement of many soil properties and processes. These roles, which largely influence soil functions, are a pool of specific contributions of different components of SOM. The soil functions, in turn, normally define the level of soil degradation, viewed as quantifiable temporal changes in a soil that impairs its quality. This paper aims at providing a generalized assessment of the current state of knowledge on the usefulness of SOM in monitoring soil degradation, based on its influence on the physical, chemical and biological properties and processes of soils...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28324220/understanding-when-a-partner-is-not-in-the-mood-sexual-communal-strength-in-couples-transitioning-to-parenthood
#8
Amy Muise, James J Kim, Emily A Impett, Natalie O Rosen
Situations in which one partner is interested in having sex but the other partner is not "in the mood" are common in relationships. We extend previous work on sexual communal strength-the motivation to be responsive to a partner's sexual needs-to demonstrate that in addition to the motivation to meet a partner's need to have sex, the motivation to be understanding about a partner's need not to engage in sex is uniquely associated with sexual and relationship satisfaction. In Study 1, we adapted a measure of sexual communal strength for having sex (SCSS) to create a new measure of sexual communal strength for not having sex (SCSN)...
March 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28324146/beliefs-about-the-potential-impacts-of-exploiting-non-timber-forest-products-predict-voluntary-participation-in-monitoring
#9
Alice Dantas Brites, Carla Morsello
Harvesting and trading non-timber forest products is advocated as a win-win strategy for conservation and development, yet it can produce negative ecological and socioeconomic impacts. Hence, monitoring exploitation outcomes is essential, and participatory monitoring has been suggested to be the most suitable approach. Among possible approaches, participatory monitoring is preferred because it is likely to increase people's awareness and beliefs regarding impacts or potential impacts, thus inducing behavioral changes, although the evidence in this regard is contradictory...
March 21, 2017: Environmental Management
https://www.readbyqxmd.com/read/28323938/loss-of-action-via-neurotensin-leptin-receptor-neurons-disrupts-leptin-and-ghrelin-mediated-control-of-energy-balance
#10
Juliette A Brown, Raluca Bugescu, Thomas Mayer, Adriana Gata-Garcia, Gizem Kurt, Hillary L Woodworth, Gina M Leinninger
The hormones ghrelin and leptin act via the lateral hypothalamic area (LHA) to modify energy balance but the underlying neural mechanisms remain unclear. We investigated how leptin and ghrelin engage LHA neurons to modify energy balance behaviors and whether there is any cross-talk between leptin and ghrelin-responsive circuits. We demonstrate that ghrelin activates LHA neurons expressing Hypocretin/Orexin (OX) to increase food intake. Leptin mediates anorectic actions via separate neurons expressing the long form of the leptin receptor (LepRb), many of which co-express the neuropeptide neurotensin (Nts); we refer to these as NtsLepRb neurons...
March 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323907/resveratrol-inhibits-androgen-production-of-human-adrenocortical-h295r-cells-by-lowering-cyp17-and-cyp21-expression-and-activities
#11
Nesa Marti, Nadia Bouchoucha, Kay-Sara Sauter, Christa E Flück
Resveratrol, a natural compound found in grapes, became very popular for its suggested protective effects against aging. It was reported to have similar positive effects on the human metabolism as caloric restriction. Recently, positive effects of resveratrol on steroid biosynthesis in cell systems and in humans suffering from polycystic ovary syndrome have also been reported, but the exact mechanism of this action remains unknown. Sirtuins seem targeted by resveratrol to mediate its action on energy homeostasis...
2017: PloS One
https://www.readbyqxmd.com/read/28323880/randomized-controlled-trials-in-central-vascular-access-devices-a-scoping-review
#12
Mari Takashima, Gillian Ray-Barruel, Amanda Ullman, Samantha Keogh, Claire M Rickard
BACKGROUND: Randomized controlled trials evaluate the effectiveness of interventions for central venous access devices, however, high complication rates remain. Scoping reviews map the available evidence and demonstrate evidence deficiencies to focus ongoing research priorities. METHOD: A scoping review (January 2006-December 2015) of randomized controlled trials evaluating the effectiveness of interventions to improve central venous access device outcomes; including peripherally inserted central catheters, non-tunneled, tunneled and totally implanted venous access catheters...
2017: PloS One
https://www.readbyqxmd.com/read/28323868/-waiting-for-daas-a-retrospective-chart-review-of-patients-with-untreated-hepatitis-c-in-rwanda
#13
Neil Gupta, Jules Kabahizi, Constance Mukabatsinda, Timothy David Walker, Emmanuel Musabeyezu, Athanase Kiromera, Jennifer Ilo Van Nuil, Kevin Steiner, Joia Mukherjee, Sabin Nsanzimana, Aimable Mbituyumuremyi
BACKGROUND: Access to treatment for hepatitis C virus (HCV) in sub-Saharan Africa is extremely limited. With the advent of direct acting antivirals (DAAs), highly effective and easy-to-deliver oral regimens are now available on the global market. This study was conducted to understand the background and characteristics of a national cohort of patients with HCV infection enrolled in care and awaiting therapy with DAAs. METHODS AND FINDINGS: We conducted a retrospective chart review of all adult patients with confirmed HCV infection who were currently enrolled in care and treatment at the four existing hepatitis referral centers in Rwanda...
2017: PloS One
https://www.readbyqxmd.com/read/28323820/selective-stalling-of-human-translation-through-small-molecule-engagement-of-the-ribosome-nascent-chain
#14
Nathanael G Lintner, Kim F McClure, Donna Petersen, Allyn T Londregan, David W Piotrowski, Liuqing Wei, Jun Xiao, Michael Bolt, Paula M Loria, Bruce Maguire, Kieran F Geoghegan, Austin Huang, Tim Rolph, Spiros Liras, Jennifer A Doudna, Robert G Dullea, Jamie H D Cate
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel. We further show that PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. Using ribosome profiling, we demonstrate that PF-06446846 is highly selective for the inhibition of PCSK9 translation...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28323677/transferable-training-modules-building-environmental-education-opportunities-with-and-for-mexican-community-health-workers-promotores-de-salud
#15
Denise Moreno Ramírez, Lourdes Vea, James A Field, Paul B Baker, A Jay Gandolfi, Raina M Maier
Community health workers (promotores de salud) have the ability to empower communities to mitigate negative health outcomes. Current training efforts in environmental topics are lacking. This project addressed this gap by developing 4 transferable training modules on environmental health. By applying a series of surveys, interviews, and trainings, we evaluated their relevance. Partners provided favorable feedback for 3 of the 4 modules. It was also learned that the development method could be improved by engaging technically trained promotores de salud in the role of co-creators...
March 20, 2017: Family & Community Health
https://www.readbyqxmd.com/read/28323608/from-doctors-stories-to-doctors-stories-and-back-again
#16
Marcia Day Childress
Stories have always been central to medicine, but during the twentieth century bioscience all but eclipsed narrative's presence in medical practice. In Doctors' Stories, published in 1991, Kathryn Montgomery excavated medicine's narrative foundations and functions to reveal new possibilities for how to conceive and characterize medicine. Physicians' engagement with stories has since flourished, especially through the narrative medicine movement, although in the twenty-first century this has been challenged by the health care industry's business-minded and data-driven clinical systems...
March 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28323549/feasibility-of-an-electronic-participant-information-system-for-adult-day-services-a-qualitative-study-of-staff-perspectives
#17
Yujun Liu, Christina Voskanova Tyhurst, Shannon E Jarrott
Adult day services (ADS) professionals have begun to explore assessment systems focused on participants. Barriers include inadequate technology, software costs, and personnel requirements. We present data from staff interviews at an ADS with an electronic participant information system. Contrary to reports about difficulties learning to use electronic systems, staff found the system manageable and data meaningful. We identify ways that community-based centers can build partnerships and utilize software to integrate assessment and electronic records to improve center performance and participant outcomes...
February 7, 2017: Home Health Care Services Quarterly
https://www.readbyqxmd.com/read/28323445/neuropsychology-in-south-africa
#18
Sharon Truter, Menachem Mazabow, Alejandra Morlett Paredes, Diego Rivera, Juan Carlos Arango-Lasprilla
This survey forms part of an international research study conducted in 39 countries and is the first to describe the characteristics of individuals engaged in the practice of neuropsychology in South Africa (SA). The purpose was to analyze the characteristics of individuals working in the profession of neuropsychology in order to understand their background, professional training, current work situation, assessment and diagnostic procedures, rehabilitation techniques, teaching responsibilities, and research activities...
March 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28323439/patient-perceptions-of-treatment-delivery-platforms-for-cognitive-behavioral-therapy-for-insomnia
#19
Janet M Y Cheung, Delwyn J Bartlett, Carol L Armour, Tracey-Lea Laba, Bandana Saini
OBJECTIVE: Stepped care has given rise to the proliferation of abbreviated CBT-I programs and delivery formats. This includes interventions delivered by allied health professionals and those delivered electronically through the Internet. This article aims to explore patient perceptions between electronic and face-to-face (FTF) delivery platforms for (abbreviated) CBT-I. PARTICIPANTS: Patients with insomnia from specialist sleep or psychology clinics and those from the general community in Sydney, Australia...
March 21, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28320071/adherence-to-national-exercise-guidelines-by-patients-attending-emergency-departments-a-multi-site-survey
#20
Paul Berlingeri, Neil Cunningham, David McD Taylor, Jonathan Knott, Daniel McLean, Rex Gavan, Luke Plant, Hayley Chen, Tracey Weiland
OBJECTIVE: The proportion of adults in Australia meeting or exceeding the national guidelines for physical activity has remained relatively static over the past 10 years. The research objective was to measure self-reported physical activity and sedentary behaviour among ED patients in accordance with Australia's current physical activity and sedentary behaviour guidelines, revised in 2014. METHODS: A convenience sample of participants was recruited from three EDs in Melbourne between February and May 2016...
March 20, 2017: Emergency Medicine Australasia: EMA
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