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https://www.readbyqxmd.com/read/29776002/the-chaos-of-hospitalisation-for-patients-with-critical-limb-ischaemia-approaching-major-amputation
#1
Susan Monaro, Sandra West, Jana Pinkova, Janice Gullick
AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families when major amputation has been advised for critical limb ischaemia (CLI). BACKGROUND: CLI creates significant burden to the health system and the family, particularly as the person with CLI approaches amputation. Major amputation is often offered as a late intervention for CLI in response to the marked deterioration of an ischaemic limb, and functional decline from reduced mobility, intractable pain, infection and/or toxaemia...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775956/typology-of-new-psychoactive-substance-use-among-the-general-australian-population
#2
Rachel Sutherland, Amy Peacock, Amanda Roxburgh, Monica J Barratt, Lucinda Burns, Raimondo Bruno
AIM: The aim of this study was to examine the typology of Australian illicit drug consumers to determine whether those who use new psychoactive substances (NPS) differ from those using other illicit substances. METHODS: Data were from the 2013 National Drug Strategy Household Survey, a representative population study; analyses were limited to participants reporting past year illicit drug use (including NPS; n = 3309). Latent class analysis identified groups based on past year substance use, and a weighted multivariable, multinomial regression model was used to examine characteristics associated with group membership...
May 3, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29775838/deconstructing-skill-learning-and-its-physiological-mechanisms
#3
Danny Spampinato, Pablo Celnik
Acquiring complex motor skills involves learning a number of distinct motor components. Two fundamental elements that constitute a skill are the internal representation (i.e., the calibration of a sensorimotor map) and the sequence of movements needed to execute the task. Learning each of these likely rely on different neural substrates such as the cerebellum and primary motor cortex (M1), and physiological mechanisms. However, the specific neurophysiological processes underlying the acquisition of these components remains poorly understood...
March 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29775775/knowledge-and-learning-of-verb-biases-in-amnesia
#4
Rachel Ryskin, Zhenghan Qi, Natalie V Covington, Melissa Duff, Sarah Brown-Schmidt
Verb bias-the co-occurrence frequencies between a verb and the syntactic structures it may appear with-is a critical and reliable linguistic cue for online sentence processing. In particular, listeners use this information to disambiguate sentences with multiple potential syntactic parses (e.g., Feel the frog with the feather.). Further, listeners dynamically update their representations of specific verbs in the face of new evidence about verb-structure co-occurrence. Yet, little is known about the biological memory systems that support the use and dynamic updating of verb bias...
May 15, 2018: Brain and Language
https://www.readbyqxmd.com/read/29775542/exercise-and-circulating-bdnf-mechanisms-of-release-and-implications-for-the-design-of-exercise-interventions
#5
Jeremy James Walsh, Michael E Tschakovsky
Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism underlying these exercise-induced benefits and is the subject of considerable attention in the exercise-brain health literature...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29775478/treadmilling-analysis-reveals-new-insights-into-dynamic-ftsz-ring-architecture
#6
Diego A Ramirez-Diaz, Daniela A García-Soriano, Ana Raso, Jonas Mücksch, Mario Feingold, Germán Rivas, Petra Schwille
FtsZ, the primary protein of the bacterial Z ring guiding cell division, has been recently shown to engage in intriguing treadmilling dynamics along the circumference of the division plane. When coreconstituted in vitro with FtsA, one of its natural membrane anchors, on flat supported membranes, these proteins assemble into dynamic chiral vortices compatible with treadmilling of curved polar filaments. Replacing FtsA by a membrane-targeting sequence (mts) to FtsZ, we have discovered conditions for the formation of dynamic rings, showing that the phenomenon is intrinsic to FtsZ...
May 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29775423/successfully-striving-for-happiness-socially-engaged-pursuits-predict-increases-in-life-satisfaction
#7
Julia M Rohrer, David Richter, Martin Brümmer, Gert G Wagner, Stefan C Schmukle
Happiness is considered a highly desirable attribute, but whether or not individuals can actively steer their lives toward greater well-being is an open empirical question. In this study, respondents from a representative German sample reported, in text format, ideas for how they could improve their life satisfaction. We investigated which of these ideas predicted changes in life satisfaction 1 year later. Active pursuits per se-as opposed to statements about external circumstances or fortune-were not associated with changes in life satisfaction ( n = 1,178)...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29775227/choosing-to-decline-finding-common-ground-through-the-perspective-of-shared-decision-making
#8
Michele Megregian, Marianne Nieuwenhuijze
Respectful communication is a key component of any clinical relationship. Shared decision making is the process of collaboration that occurs between a health care provider and patient in order to make health care decisions based upon the best available evidence and the individual's preferences. A midwife and woman (and her support persons) engage together to make health care decisions, using respectful communication that is based upon the best available evidence and the woman's preferences, values, and goals...
May 18, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29775141/effects-of-structured-group-reminiscence-therapy-on-the-life-satisfaction-of-institutionalized-older-adults-in-taiwan
#9
Yao Ching-Teng, Lin Chia-Ju, Liu Hsiu-Yueh
Health issues common among older adults living in institution settings include poor life satisfaction and depression conditions. Engagement in appropriate group reminiscence therapy programs could alleviate these health issues among older adults in long-term care institutions. This study tested the effectiveness of a structured group reminiscence therapy protocol on the life satisfaction of institutionalized older adults. A quasi-experimental design was applied. A convenience sample of older adults was drawn from two nursing homes in southern Taiwan...
May 18, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29775113/how-does-leadership-manifest-in-the-patient-therapist-interaction-among-physiotherapists-in-primary-health-care-a-qualitative-study
#10
Eva Rasmussen-Barr, Mairi Savage, Mia Von Knorring
OBJECTIVES: Health care is undergoing changes and this requires the participation and leadership of all health-care professions. While numerous studies have explored leadership competence among physicians and nurses, the physiotherapy profession has received but limited attention. The aim of this study was to explore how leadership manifests in the patient-therapist interaction among physiotherapists in primary health care and how the physiotherapists themselves relate their perception of leadership to their clinical practice...
May 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29774666/-engagement-ring-image-conveys-regrettable-outcome-for-aged-patients-with-non-small-cell-lung-cancer
#11
Hiromichi Yamane, Hiroyuki Nishie, Nobuaki Ochi, Tomoko Yamagishi, Nozomu Nakagawa, Yasunari Nagasaki, Hidekazu Nakanishi, Nagio Takigawa
No abstract text is available yet for this article.
May 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29774654/a-photoactivatable-%C3%AE-5%C3%AE-1-specific-integrin-ligand
#12
Aranzazu Del Campo, Roshna V Nair, Aleeza Farrukh
The integrin α5β1 is overexpressed in colon, breast, ovarian, lung and brain tumors and has been identified as key component in mechanosensing. In order to study how dynamic changes of α5β1 engagement affect cellular behaviour, photoactivatable derivatives of α5β1 specific ligands are presented in this article. A photoremovable protecting group (PRPG) was introduced into the ligand structure at a relevant position for integrin recognition. The presence of the chromophore temporally inhibited ligand bioactivity...
May 18, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29774476/japanese-physicians-attitudes-toward-end-of-life-discussion-with-pediatric-patients-with-cancer
#13
Saran Yoshida, Chitose Ogawa, Ken Shimizu, Mariko Kobayashi, Hironobu Inoguchi, Yoshio Oshima, Chikako Dotani, Rika Nakahara, Masashi Kato
PURPOSE: We explored pediatricians' practices and attitudes concerning end-of-life discussions (EOLds) with pediatric patients with cancer, and identified the determinants of pediatricians' positive attitude toward having EOLds with pediatric patients. METHODS: A multicenter questionnaire survey was conducted with 127 pediatricians specializing in the treatment of pediatric cancer. RESULTS: Forty-two percent of participants reported that EOLds should be held with the young group of children (6-9 years old), 68% with the middle group (10-15 years old), and 93% with the old group (16-18 years old)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29774442/integrated-models-of-care-for-individuals-with-opioid-use-disorder-how-do-we-prevent-hiv-and-hcv
#14
REVIEW
Katherine M Rich, Joshua Bia, Frederick L Altice, Judith Feinberg
PURPOSE OF REVIEW: To describe models of integrated and co-located care for opioid use disorder (OUD), hepatitis C (HCV), and HIV. RECENT FINDINGS: The design and scale-up of multidisciplinary care models that engage, retain, and treat individuals with HIV, HCV, and OUD are critical to preventing continued spread of HIV and HCV. We identified 17 models within primary care (N = 3), HIV specialty care (N = 5), opioid treatment programs (N = 6), transitional clinics (N = 2), and community-based harm reduction programs (N = 1), as well as two emerging models...
May 17, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29774358/successful-ageing-in-singapore-prevalence-and-correlates-from-a-national-survey-of-older-adults
#15
Mythily Subramaniam, Edimansyah Abdin, Janhavi A Vaingankar, Rajeswari Sambasivam, Esmond Seow, Louisa Picco, Hong Choon Chua, Rathi Mahendran, Li Ling Ng, Siow Ann Chong
INTRODUCTION: The current study aimed to estimate the overall prevalence and sociodemographic correlates of successful ageing, as defined by Rowe and Kahn, among a national sample of multiethnic adults aged 60 years and older in Singapore. METHODS: Data from older adults who participated in the Well-being of the Singapore Elderly study were analysed in the present study. Successful ageing included five indicators: no major diseases; no disability; high cognitive functioning; high physical functioning; and active engagement with life...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29774264/development-of-a-health-promotion-programme-to-improve-awareness-of-factors-that-affect-fertility-and-evaluation-of-its-reach-in-the-first-5-years
#16
Karin Hammarberg, Robert J Norman, Sarah Robertson, Robert McLachlan, Janet Michelmore, Louise Johnson
Awareness among people of reproductive age about the factors that influence fertility and reproductive outcomes, including medically assisted reproduction outcomes, is generally low. To improve awareness about the potentially modifiable factors that affect fertility and reproductive outcomes, 'Your Fertility', a fertility health promotion programme funded by the Australian Government, was established in 2011. This paper describes the development and evaluation of the reach of the Your Fertility programme from its inception in 2011 to June 2016...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774062/-in-vivo-imaging-biomarkers-of-neuroinflammation-in-the-development-and-assessment-of-stroke-therapies-towards-clinical-translation
#17
REVIEW
Bastian Zinnhardt, Maximilian Wiesmann, Lisa Honold, Cristina Barca, Michael Schäfers, Amanda J Kiliaan, Andreas H Jacobs
Modulation of the inflammatory microenvironment after stroke opens a new avenue for the development of novel neurorestorative therapies in stroke. Understanding the spatio-temporal profile of (neuro-)inflammatory imaging biomarkers in detail thereby represents a crucial factor in the development and application of immunomodulatory therapies. The early integration of quantitative molecular imaging biomarkers in stroke drug development may provide key information about (i) early diagnosis and follow-up, (ii) spatio-temporal drug-target engagement (pharmacodynamic biomarker), (iii) differentiation of responders and non-responders in the patient cohort (inclusion/exclusion criteria; predictive biomarkers), and (iv) the mechanism of action...
2018: Theranostics
https://www.readbyqxmd.com/read/29774007/the-influence-of-sexual-orientation-on-the-perceived-fit-of-male-applicants-for-both-male-and-female-typed-jobs
#18
Heather M Clarke, Kara A Arnold
Research demonstrates the bias faced by individuals engaged in occupations that are perceived as inconsistent with their gender. The lack of fit model and role congruity theory explain how gender stereotypes give rise to the perception that an individual lacks the attributes necessary to be successful in a gender-incongruent job. Men employed in jobs traditionally held by women are perceived as wimpy and undeserving of respect. The majority of studies in this area have, however, failed to account for the sexual orientation of the individual being rated...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29773982/training-rats-using-water-rewards-without-water-restriction
#19
Pamela Reinagel
High-throughput behavioral training of rodents has been a transformative development for systems neuroscience. Water or food restriction is typically required to motivate task engagement. We hypothesized a gap between physiological water need and hedonic water satiety that could be leveraged to train rats for water rewards without water restriction. We show that when Citric Acid (CA) is added to water, female rats drink less, yet consume enough to maintain long term health. With 24 h/day access to a visual task with water rewards, rats with ad lib CA water performed 84% ± 18% as many trials as in the same task under water restriction...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#20
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
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