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https://www.readbyqxmd.com/read/28806777/a-synthetic-sickness-screen-for-senescence-re-engagement-targets-in-mutant-cancer-backgrounds
#1
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents and an incomplete understanding of the signalling events underlying this complex process. In order to address this issue we undertook a large-scale morphological siRNA screen for inducers of senescence phenotypes in the human melanoma cell line A375P...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28806753/accelerometer-derived-physical-activity-and-sedentary-time-by-cancer-type-in-the-united-states
#2
Keith M Thraen-Borowski, Keith P Gennuso, Lisa Cadmus-Bertram
The 2003-2004 and 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES) were among the first population-level studies to incorporate objectively measured physical activity and sedentary behavior, allowing for greater understanding of these behaviors. However, there has yet to be a comprehensive examination of these data in cancer survivors, including short- and long-term survivors of all cancer types. Therefore, the purpose of this analysis was to use these data to describe activity behaviors in short- and long-term cancer survivors of various types...
2017: PloS One
https://www.readbyqxmd.com/read/28806744/sustainability-of-knowledge-implementation-in-a-low-and-middle-income-context-experiences-from-a-facilitation-project-in-vietnam-targeting-maternal-and-neonatal-health
#3
Leif Eriksson, Anna Bergström, Dinh Thi Phuong Hoa, Nguyen Thu Nga, Ann Catrine Eldh
BACKGROUND: In a previous trial in Vietnam, a facilitation strategy to secure evidence-based practice in primary care resulted in reduced neonatal mortality over a period of three years. While little is known as to what ensures sustainability in the implementation of community-based strategies, the aim of this study was to investigate factors promoting or hindering implementation, and sustainability of knowledge implementation strategies, by means of the former Neonatal Knowledge Into Practice (NeoKIP) trial...
2017: PloS One
https://www.readbyqxmd.com/read/28806713/activity-groups-for-persons-with-dementia-personal-predictors-of-participation-engagement-and-mood
#4
Jiska Cohen-Mansfield
This study examined the relationship between personal characteristics and attendance, engagement, sleep, and mood outcomes of persons with dementia participating in group activities. The purpose of this study is to examine which persons with dementia benefit most from group interventions. Sixty-nine persons with dementia were observed by research and therapeutic recreation staff during 10 types of group activities (reading aloud with discussion, choral-singing, baking, creative storytelling, brain games, active games, exercise, reminiscence poetry, holiday newsletter, and holiday discussions) on multiple outcomes (attendance duration, sleep, engagement, active participation, attitude, and positive mood)...
July 25, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28806618/public-sentiment-and-discourse-about-zika-virus-on-instagram
#5
E K Seltzer, E Horst-Martz, M Lu, R M Merchant
OBJECTIVE: Social media have strongly influenced the awareness and perceptions of public health emergencies, and a considerable amount of social media content is now shared through images, rather than text alone. This content can impact preparedness and response due to the popularity and real-time nature of social media platforms. We sought to explore how the image-sharing platform Instagram is used for information dissemination and conversation during the current Zika outbreak. STUDY DESIGN: This was a retrospective review of publicly posted images about Zika on Instagram...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28806614/altered-interaction-with-environmental-reinforcers-in-major-depressive-disorder-relationship-to-anhedonia
#6
Joanna E Szczepanik, Maura L Furey, Allison C Nugent, Ioline D Henter, Carlos A Zarate, Carl W Lejuez
Anhedonia-defined as loss of interest or pleasure-is one of two core symptoms of major depressive disorder (MDD). Anhedonia may involve decreased enjoyment of potentially rewarding activities and decreased motivation to engage in such activities. Increased engagement with reinforcers-activities with the potential to be positive experiences-is a frequent target of cognitive-behavioral therapies. Nevertheless, how environmental reinforcers are perceived, and how decisions to approach or avoid them are made by individuals with MDD, is largely unknown...
August 3, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28806555/environmental-and-socio-economic-sustainability-appraisal-of-contaminated-land-remediation-strategies-a-case-study-at-a-mega-site-in-china
#7
Yinan Song, Deyi Hou, Junli Zhang, David O'Connor, Guanghe Li, Qingbao Gu, Shupeng Li, Peng Liu
Green and sustainable remediation (GSR) has become a global trend in the contaminated land remediation field. Growing numbers of countries have adopted GSR procedures published in regulatory and/or technical guidance. China is fast becoming one of the largest remediation markets in the world, and is beginning to engage with GSR. Among other efforts, a taskforce is currently developing the first Chinese technical standard on GSR. This paper presents the context positioning and development of a sustainable remediation assessment indicator set for China...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28806495/international-uptake-of-a-proven-intervention-to-reduce-death-and-dependency-in-acute-stroke-a-cross-sectional-survey-following-the-qasc-trial
#8
Sandy Middleton, Dominik Bruch, Cintia Martinez-Garduno, Simeon Dale, Maria McNamara
BACKGROUND: Uptake of proven interventions requires dedicated resources that may only result in local implementation, thus precluding international practice change. We explored international uptake through online dissemination of the fever, sugar, and swallow (FeSS) protocols from the Quality in Acute Stroke Care (QASC) trial, which showed decreased death and dependency by 15.7% 90-day poststroke. AIMS: To identify: (a) the clinical discipline of healthcare professionals who downloaded the QASC resources; (b) the purpose for downloading; (c) successful implementation of any or all the FeSS protocols; (d) barriers to implementation; and (e) associations with self-reported successful implementation...
August 14, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28806465/safe-infant-sleep-practices-parental-engagement-education-and-behavior-change
#9
Sunah S Hwang, Michael J Corwin
Although the incidence of sudden unexpected infant death declined by nearly 50% in the 1990s, there has been little improvement in the past 15 years. Significant disparities in infant sleep practices and sleep-associated death exist, particularly by maternal race/ethnicity. This article provides a brief overview of recent observational and intervention studies related to infant sleep practices to describe the context and motivation for the population-based Study of Attitudes and Factors Effecting Infant Care (SAFE)...
August 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28806409/the-paradox-of-helping-contradictory-effects-of-scaffolding-people-with-aphasia-to-communicate
#10
Alex Gillespie, Julie Hald
When interacting with people with aphasia, communication partners use a range of subtle strategies to scaffold, or facilitate, expression and comprehension. The present article analyses the unintended effects of these ostensibly helpful acts. Twenty people with aphasia and their main communication partners (n = 40) living in the UK were video recorded engaging in a joint task. Three analyses reveal that: (1) scaffolding is widespread and mostly effective, (2) the conversations are dominated by communication partners, and (3) people with aphasia both request and resist help...
2017: PloS One
https://www.readbyqxmd.com/read/28806374/long-acting-reversible-contraception-among-homeless-women-veterans-with-chronic-health-conditions-a-retrospective-cohort-study
#11
Lori M Gawron, Andrew Redd, Ying Suo, Warren Pettey, David K Turok, Adi V Gundlapalli
BACKGROUND: US women Veterans are at increased risk of homelessness and chronic health conditions associated with unintended pregnancy. Veterans Health Administration (VHA) provision of long-acting reversible contraception (LARC) can assist in healthy pregnancy planning. OBJECTIVES: To evaluate perinatal risk factors and LARC exposure in ever-homeless women Veterans. RESEARCH DESIGN: A retrospective cohort study of women Veterans using VHA administrative data from fiscal years 2002-2015...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806373/patient-aligned-care-team-engagement-to-connect-veterans-experiencing-homelessness-with-appropriate-health-care
#12
Adi V Gundlapalli, Andrew Redd, Daniel Bolton, Megan E Vanneman, Marjorie E Carter, Erin Johnson, Matthew H Samore, Jamison D Fargo, Thomas P O'Toole
BACKGROUND: Veterans experiencing homelessness frequently use emergency and urgent care (ED). OBJECTIVE: To examine the effect of a Patient-aligned Care Team (PACT) model tailored to the unique needs of Veterans experiencing homelessness (H-PACT) on frequency and type of ED visits in Veterans Health Administration (VHA) medical facilities. RESEARCH DESIGN: During a 12-month period, ED visits for 3981 homeless Veterans enrolled in (1) H-PACT at 20 VHA medical centers (enrolled) were compared with those of (2) 24,363 homeless Veterans not enrolled in H-PACT at the same sites (nonenrolled), and (3) 23,542 homeless Veterans at 12 non-H-PACT sites (usual care) using a difference-in-differences approach...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806371/transgender-veterans-satisfaction-with-care-and-unmet-health-needs
#13
Keren Lehavot, Jodie G Katon, Tracy L Simpson, Jillian C Shipherd
BACKGROUND: Transgender individuals are overrepresented among Veterans. However, little is known regarding their satisfaction with Veterans Administration (VA) care and unmet health needs. OBJECTIVES: This study examined transgender Veterans' satisfaction with VA medical and mental health care, prevalence of delaying care, and correlates of these outcomes. RESEARCH DESIGN: We used data from transgender Veterans collected in 2014 through an online, national survey...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806367/creating-a-toolkit-to-reduce-disparities-in-patient-engagement
#14
Shimrit Keddem, Aneeza Z Agha, Judith A Long, Rachel M Werner, Judy A Shea
BACKGROUND: Patient engagement has become a major focus of health care improvement efforts nationally. Although evidence suggests patient engagement can be beneficial to patients, it has not been consistently defined, operationalized, or translated into practice. OBJECTIVES: Our objective was to develop a toolkit to help providers increase patient engagement and reduce disparities in patient engagement. RESEARCH DESIGN: We used qualitative interviews and observations with staff at primary care sites nationally to identify patient engagement practices and resources used to engage patients...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806277/nursing-faculty-attitudes-and-practices-related-to-online-teaching
#15
Lisa Broussard, Kathleen Wilson
Online education as a teaching methodology is relatively new in higher education in comparison to traditional face-to-face instruction. There is often concern that the quality of online classes is inferior and that academic rigor is compromised when faculty are not engaged with students in a classroom. The purpose of this pilot study was to assess nursing faculty attitudes and practices regarding online teaching. Findings indicated that overall, faculty feel that achievement of student learning outcomes in online and hybrid settings is comparable to face-to-face and report excitement with most aspects of teaching online...
August 10, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28806230/a-multifaceted-model-to-evaluate-interprofessional-education-in-clinical-nurse-specialist-programs
#16
Heather Becker, Gayle M Timmerman, Carole Delville, EunJin Seo
PURPOSE: Preparing students to engage in team-based healthcare is a major focus of clinical nurse specialist (CNS) education programs. A robust evaluation plan is needed to monitor achievement of key outcomes in this complex undertaking. DESCRIPTION: Informed by the work of Kirkpatrick and Stufflebeam, an evaluation model that incorporates multiple information sources about process and outcomes related to interprofessional (IP) education is proposed. OUTCOME: Improvements in scores on attitude and competency measures suggest that the program had the desired effects on students' attitudes and self-efficacy for IP collaboration and was validated by faculty clinical observations of IP communication and teamwork...
September 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28806202/alzheimer-s-disease-caregiver-s-health-and-important-resources-next-steps-in-intervention-research
#17
Kharah M Ross, Judith E Carroll
In this issue of Psychosomatic Medicine, Mausbach and colleagues report that Alzheimer's disease (AD) caregivers who engage in more pleasant leisure activities had lower blood pressure over 5 years compared to those who engage in fewer leisure activities. This novel finding suggests that something as simple as taking more walks in the park or more time for reading books could protect the physical health of caregivers. In this editorial, we review possible mechanisms linking pleasant leisure activities with lower blood pressure in caregivers, and discuss potential barriers that prevent caregivers from engaging in pleasant leisure activities...
August 11, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28806127/therapeutic-communication-in-mental-health-nursing-aesthetic-and-metaphoric-processes-in-the-engagement-with-challenging-patients
#18
Jeremy Mills
No abstract text is available yet for this article.
August 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28806101/homeless-women-s-service-use-barriers-and-motivation-for-participating-in-substance-use-treatment
#19
Carole C Upshur, Darlene Jenkins, Linda Weinreb, Lillian Gelberg, Elizabeth Aaker Orvek
BACKGROUND: Homeless women are at high risk for substance use disorder (SUD), and are a growing proportion of the homeless population. However, homeless women experience barriers to engaging in substance use services. OBJECTIVES: Among homeless women with SUD, to explore service use, motivation to change, service barriers, and willingness to have substance use and mental health problems addressed in primary health care. METHODS: Women with SUD were sampled from 11 Health Care for the Homeless (HCH) primary care clinics in 9 states, yielding 241 with either an alcohol or drug use disorder who then completed questions about SUD services...
August 14, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28806037/quality-focus-beneficiary-and-family-engagement
#20
Stephan D Schroeder
No abstract text is available yet for this article.
September 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
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