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Lynn W Bush, Louis E Bartoshesky, Karen L David, Benjamin Wilfond, Janet L Williams, Ingrid A Holm
Disclaimer: This article is designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality patient care. Adherence to the information contained in this article does not necessarily assure a successful medical outcome. This information and any associated recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, each provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Simon Burall
No abstract text is available yet for this article.
March 22, 2018: Nature
(no author information available yet)
No abstract text is available yet for this article.
March 22, 2018: Nature
Jaein Seo, B Douglas Smith, Elihu Estey, Ernest Voyard, Bernadette O' Donoghue, John F P Bridges
OBJECTIVE: Acute myeloid leukemia (AML) is a progressive blood cancer with few effective treatment options. As part of a patient-focused drug development (PFDD) initiative led by the Leukemia and Lymphoma Society (LLS), we sought to use a community-centered approach to develop and pilot an instrument to measure patient preferences for the benefits and risks of treating AML. METHODS: Instrument development was informed by a literature review, engagement with expert stakeholders (n = 12), engagement with community stakeholders, and pretesting...
March 22, 2018: Current Medical Research and Opinion
Alonso Hormazábal-Peralta, Javier Espinoza, Pablo Cáceres, Pablo A Lizana
OBJECTIVES: Physical activity (PA) has been shown to have multiple health and wellness benefits, but there is no such information for adolescents with high intellectual ability (HIA). Thus, the aim of this study is to assess body composition and PA in HIA Chilean adolescents. METHODS: Weight and body composition were measured by bioelectrical impedance in 73 adolescents (39 female) aged 14-18 years from the Valparaíso region of Chile. HIA was assessed via Raven's Progressive Matrices (> 75th percentile) and PA, via questionnaire...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jennifer Oates
AIM: The aim of this article is to present selected findings from a doctoral study on the subjective well-being and subjective experience of mental health problems in UK mental health nurses. Here the concept of 'nurses' well-being' is explored. METHOD: Data were drawn from a survey of 237 mental health nurses about their mental health and well-being and from interviews with 27 mental health nurses with personal experience of mental health problems and high subjective well-being...
March 22, 2018: Nursing Management (Harrow)
Lingci Zhao, Irina P Suarez, Diego F Gauto, Rodolfo M Rasia, Jin Wang
The intrinsically disordered protein domain DCL1-A is the first report of a complete double stranded RNA binding domain folding upon binding. DCL1-A recognizes the dsRNA by acquiring a well-folded structure after engagement with its interaction partner. Despite the structural characterization of the interaction complex underlying the recognition of dsRNA has been established, the dynamics of disorder-to-order transitions in the binding process remains elusive. Here we have developed a coarse-grained structure-based model with consideration of electrostatic interactions to explore the mechanism of the coupled folding and binding...
March 22, 2018: Physical Chemistry Chemical Physics: PCCP
Anna Maria Grugnetti, Cristina Arrigoni, Maria Antonietta Fusco, Arianna Magon, Adele Sgarella, Maria Luisa Gallotti, Giuseppina Grugnetti, Rosario Caruso
Distress could be often experienced by breast cancer patients with chemotherapy-induced alopecia. Those distress assessment is strategic to deliver care in a tailored way, enhancing the overall wellbeing. So far, those distress is measurable by the Chemotherapy-induced Alopecia Distress Scale (CADS), which is not yet available in Italian, due to there are no validation studies on this topic. For this reason, the aim of this study was to validate and adapt Chemotherapy-induced Alopecia Distress Scale within the Italian context (I-CADS)...
March 2018: Recenti Progressi in Medicina
Anne G Pereira, Michael Kim, Marcus Seywerd, Brooke Nesbitt, Michael B Pitt
BACKGROUND: Use of the electronic health record (EHR) is widespread in academic medical centers, and hands-on EHR experience in medical school is essential for new residents to be able to meaningfully contribute to patient care. As system-specific EHR training is not portable across institutions-even when the same EHR platform is used-students rotating across health systems are often required to spend time away from clinical training to complete each system's, often duplicative, EHR training regardless of their competency within the EHR...
January 2018: Applied Clinical Informatics
Yoko Miura
Retinal pigment epithelium (RPE), a monolayer of epithelial cells located between the neural retina and the choroid, plays a significant role in the maintenance of retinal function. Its in vivo imaging is still technically challenging in human eye. With the mouse eye, there is a possibility to look into the RPE through the sclera using two-photon microscopy (TPM). TPM is a two photon-excited nonlinear fluorescence microscopy that enables the observation of deep tissues up to several hundred micrometers. Since the simultaneous absorption of two photons occurs only at the focal plane, spatial resolution of the TPM is quite high, such that pinhole as used in a confocal microscope is not necessary...
2018: Methods in Molecular Biology
Shawna J Lee, Diana T Sanchez, Andrew Grogan-Kaylor, Joyce Y Lee, Analia Albuja
Objective To examine the association of father early engagement behaviors and infant low birth weight (LBW) among unmarried, urban couples. Methods Participants were from the Fragile Families and Child Wellbeing Study, a birth-cohort study of urban families. We conducted cross-sectional analyses of data from interviews with unmarried mothers and fathers (N = 2726) that took place at the time of their child's birth. Early engagement behaviors were based on fathers' self-report of whether during the pregnancy they gave mothers money to buy things for the baby, helped in other ways like providing transportation to prenatal clinics, and attended the birth...
March 21, 2018: Maternal and Child Health Journal
Jed D Gonzalo, Deanna Graaf, Amarpreet Ahluwalia, Dan R Wolpaw, Britta M Thompson
After emphasizing biomedical and clinical sciences for over a century, US medical schools are expanding experiential roles that allow students to learn about health care delivery while also adding value to patient care. After developing a program where all 1st-year medical students are integrated into interprofessional care teams to contribute to patient care, authors use a diffusion of innovations framework to explore and identify barriers, facilitators, and best practices for implementing value-added clinical systems learning roles...
March 21, 2018: Advances in Health Sciences Education: Theory and Practice
Matthew Chojnacki, Lori K Fenton
The Mars Science Laboratory rover Curiosity engaged in a monthlong campaign investigating the Bagnold dune field in Gale crater. What represents the first in situ investigation of a dune field on another planet has resulted in a number of discoveries. Collectively, the Curiosity rover team has compiled the most comprehensive survey of any extraterrestrial aeolian system visited to date with results that yield important insights into a number of processes, including sediment transport, bed form morphology and structure, chemical and physical composition of aeolian sand, and wind regime characteristics...
November 2017: Journal of Geophysical Research. Planets
Joanna Morrison, Issarapa Chunsuwan, Petch Bunnag, Petra C Gronholm, Georgia Lockwood Estrin
Introduction: In low-income and middle-income countries, it is estimated that one in every three preschool-age children are failing to meet cognitive or socioemotional developmental milestones. Thailand has implemented a universal national developmental screening programme (DSPM) for young children to enable detection of developmental disorders and early intervention that can improve child health outcomes. DSPM implementation is being hampered by low attendance at follow-up appointments when children fail the initial screening...
2018: BMJ Global Health
Ummuhan Isoglu-Alkac, M Numan Ermutlu, Gökçer Eskikurt, İlker Yücesir, Sernaz Demirel Temel, Tan Temel
Physical exercise and the training effects of repeated practice of skills over an extended period of time may have additive effects on brain networks and functions. Various motor skills and attentional styles can be developed by athletes engaged in different sports. In this study, the effects of fast ball sports and dance training on attention were investigated by event related potentials (ERP). ERP were recorded in auditory and visual tasks in professional dancer, professional fast ball sports athlete (FBSA) and healthy control volunteer groups consisting of twelve subjects each...
April 2018: Cognitive Neurodynamics
Michael S Parker, Ambikaipakan Balasubramaniam, Floyd R Sallee, Steven L Parker
Eukaryote ribosomal RNAs (rRNAs) have expanded in the course of phylogeny by addition of nucleotides in specific insertion areas, the expansion segments. These number about 40 in the larger (25-28S) rRNA (up to 2,400 nucleotides), and about 12 in the smaller (18S) rRNA (<700 nucleotides). Expansion of the larger rRNA shows a clear phylogenetic increase, with a dramatic rise in mammals and especially in hominids. Substantial portions of expansion segments in this RNA are not bound to ribosomal proteins, and may engage extraneous interactants, including messenger RNAs (mRNAs)...
2018: Frontiers in Genetics
Antonio A Nunez, Lily Yan, Laura Smale
For humans, activity during the night is correlated with multiple pathologies that may reflect a lack of harmony among components of the circadian system; however, it remains difficult to identify causal links between nocturnal activity and different pathologies based on the data available from epidemiological studies. Animal models that use forced activity or timed sleep deprivation provide evidence of circadian disruptions that may be at the core of the health risks faced by human night and shift workers...
2018: Frontiers in Endocrinology
Yari Gvion, Yossi Levi-Belz
Background: One of the main obstacles in studying suicide risk factors is the difference between cases in which the individual died by suicide and those in which the individual engaged in suicidal behavior. A promising strategy that overcomes this obstacle is the study of survivors of serious suicide attempt (SSA), i.e., an attempt that would have been lethal had it not been for the provision of rapid and effective emergency treatment. Serious suicide attempters are epidemiologically very much like those who died by suicide, and thus may serve as valid proxies for studying suicides...
2018: Frontiers in Psychiatry
Hayden B Bosworth, Barbara Ngouyombo, Jan Liska, Leah L Zullig, Caroline Atlani, Anne C Beal
Lipid-lowering medications have been shown to be efficacious, but adherence is suboptimal. This is a narrative, perspective review of recently published literature in the field of medication adherence research for lipid-lowering medications. We provide an overview of the impact of suboptimal adherence and use a World Health Organization framework (patient, condition, therapy, socioeconomic, and health system-related systems) to discuss factors that influence hyperlipidemia treatment adherence. Further, the review involves an evaluation of intervention strategies to increase hyperlipidemia treatment adherence with a special focus on mHealth interventions, patient reminders on packaging labels, nurse- and pharmacist-led interventions, and health teams...
2018: Patient Preference and Adherence
Jin-Yu Yang, Xiang-Yu Deng, Yi-Sheng Li, Xian-Cai Ma, Jian-Xiong Feng, Bing Yu, Yang Chen, Yi-Ling Luo, Xi Wang, Mei-Ling Chen, Zhi-Xin Fang, Fu-Xiang Zheng, Yi-Ping Li, Qian Zhong, Tie-Bang Kang, Li-Bing Song, Rui-Hua Xu, Mu-Sheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao
Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3'-terminus of tRNA at the acceptor stem...
March 21, 2018: Nature Communications
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