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Burns evaluation

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https://www.readbyqxmd.com/read/29329593/targeting-ectodysplasin-promotor-by-crispr-dcas9-effector-effectively-induces-the-reprogramming-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-sweat-gland-like-cells
#1
Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs)...
January 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29327480/membrane-active-peptide-pv3-efficiently-eradicates-multidrug-resistant-pseudomonas-aeruginosa-in-a-mouse-model-of-burn-infection
#2
Hamed Memariani, Delavar Shahbazzadeh, Jean-Marc Sabatier, Kamran Pooshang Bagheri
The aim of this study was to evaluate the topical bactericidal activity of peptide PV3 against a MDR isolate of Pseudomonas aeruginosa in a mouse model of burn infection. The structural analysis of PV3 by circular dichroism spectroscopy indicated a low peptide helical content in water, whereas a high helical content was observed in the presence of the more hydrophobic 50% (v/v) trifluoroethanol/water buffer. A confocal microscopy analysis indicated that the main action of PV3 occurred at the membrane of bacteria...
January 12, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29327283/persea-americana-mill-crude-extract-exhibits-antinociceptive-effect-on-uvb-radiation-induced-skin-injury-in-mice
#3
Viviane C K N Deuschle, Indiara Brusco, Mariana Piana, Henrique Faccin, Leandro Machado de Carvalho, Sara Marchesan Oliveira, Carine Viana
Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. americana leaf extract in a UVB irradiation-induced burn model in mice and performed a gel-formulation stability study. The antinociceptive and anti-inflammatory effect was evaluated through mechanical allodynia, paw oedema, and inflammatory cell infiltration...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29325546/development-and-evaluation-of-a-measure-of-patient-reported-symptoms-of-blepharitis
#4
Kamran Hosseini, Linda B Bourque, Ron D Hays
BACKGROUND: Blepharitis is an ocular surface disease and chronic ophthalmic condition. This paper reports on the development of psychometric evaluation of a patient-reported measure of blepharitis symptoms. METHODS: Self-reports of 13 blepharitis symptoms collected in a Phase 3 multi-site, randomized, double-masked, 4-arm parallel group, clinical trial of 907 individuals with blepharitis (mean age = 62, range: 19-93; 57% female) were analyzed. Symptoms asked about were: eyes that itch; eyes that burn; eyelids feel heavy or puffy; feel like something is in your eye; dry eyes; gritty eyes; irritated eyes; eyes that tear or water; crusty eyes; flaking from your eyelids; eyelids that are stuck together; red eyes or eyelids; and debris like pieces of skin or dandruff in your eyes...
January 11, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29324432/an-overview-of-clinical-and-health-economic-evidence-regarding-porcine-small-intestine-submucosa-extracellular-matrix-in-the-management-of-chronic-wounds-and-burns
#5
Leo M Nherera, Marco Romanelli, Paul Trueman, Valentina Dini
Small intestine submucosa (SIS) has been extensively evaluated in preclinical models and developed into commercially produced medical technologies intended for use in several different indications. The SIS extracellular matrix cellular and/or tissue-based product is a commercially available, porcine-derived SIS dressing. The purpose of this review was to consider the role of the SIS dressing in the management of chronic wounds and burns. Using a variety of search terms from the literature to describe the SIS dressing, the following databases were searched: PubMed, York Centre for Reviews and Dissemination database, National Health Service Economic Evaluation database, Health Technology Assessment database, and the Cochrane Library...
December 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29323928/association-between-household-air-pollution-exposure-and-chronic-obstructive-pulmonary-disease-outcomes-in-13-low-and-middle-income-country-settings
#6
Trishul Siddharthan, Matthew R Grigsby, Dina Goodman, Muhammad Chowdhury, Adolfo Rubenstein, Vilma Irazola, Laura Gutierrez, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert Jones, Frederick van Gemert, Robert A Wise, William Checkley
RATIONALE: Forty percent of households worldwide burn biomass fuels for energy, which may be most the important contributor to household air pollution. OBJECTIVE: To examine the association between household air pollution exposure and COPD outcomes in 13 resource-poor settings. METHODS: We analyzed data from 12,396 adult participants living in 13 resource-poor, population-based settings. Household air pollution exposure was defined as using biomass materials as the primary fuel source in the home...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29322537/comparative-evaluations-of-hypertrophic-scar-formation-in-in-vivo-models
#7
Myeongjin Kim, Hyejin Kim, Hyun Wook Kang
BACKGROUND AND OBJECTIVE: Hypertrophic scar (HTS) results from a connective tissue reaction to trauma, inflammation, surgery, or burn on skin. In spite of various techniques for wound generation, the degree of scar in animal models after healing is still unpredictable and less reproducible. The objective of the current study was to identify the appropriate method to create the maximal HTS tissue in a reliable manner by comparing three different methods in vivo. MATERIALS AND METHODS: A 27 ICR mice were tested for the in vivo evaluations...
January 11, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29321849/population-genomics-and-geographical-parthenogenesis-in-japanese-harvestmen-opiliones-sclerosomatidae-leiobunum
#8
Mercedes Burns, Marshal Hedin, Nobuo Tsurusaki
Naturally occurring population variation in reproductive mode presents an opportunity for researchers to test hypotheses regarding the evolution of sex. Asexual reproduction frequently assumes a geographical pattern, in which parthenogenesis-dominated populations are more broadly dispersed than their sexual conspecifics. We evaluate the geographical distribution of genomic signatures associated with parthenogenesis using nuclear and mitochondrial DNA sequence data from two Japanese harvestman sister taxa, Leiobunum manubriatum and Leiobunum globosum...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321048/danish-first-aid-books-compliance-with-the-new-evidence-based-non-resuscitative-first-aid-guidelines
#9
Theo Walther Jensen, Thea Palsgaard Møller, Søren Viereck, Jens Roland, Thomas Egesborg Pedersen, Freddy K Lippert
BACKGROUND: The European Resuscitation Council (ERC) released new guidelines on resuscitation in 2015. For the first time, the guidelines included a separate chapter on first aid for laypersons. We analysed the current major Danish national first aid books to identify potential inconsistencies between the current books and the new evidence-based first aid guidelines. METHODS: We identified first aid books from all the first aid courses offered by major Danish suppliers...
January 10, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29320878/exercise-training-for-improving-outcomes-post-burns-a-systematic-review-and-meta-analysis
#10
Orlando Flores, Zephanie Tyack, Kellie Stockton, Robert Ware, Jennifer D Paratz
OBJECTIVES: To determine the effectiveness of different modalities of exercise and to evaluate the safety of exercise-based interventions post-burns. DATA SOURCES: Six databases were searched from inception to October 2017 using "burn," "exercise" and synonyms as keywords. Relevant authors, key journals and reference lists of included studies were hand-searched. REVIEW METHODS: Articles reporting on exercise interventions in patients post-burn and considering physical, physiological or psychological outcomes were considered...
January 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29320573/an-evaluation-of-three-dimensional-photogrammetric-and-morphometric-techniques-for-estimating-volume-and-mass-in-weddell-seals-leptonychotes-weddellii
#11
Roxanne S Beltran, Brandi Ruscher-Hill, Amy L Kirkham, Jennifer M Burns
Body mass dynamics of animals can indicate critical associations between extrinsic factors and population vital rates. Photogrammetry can be used to estimate mass of individuals in species whose life histories make it logistically difficult to obtain direct body mass measurements. Such studies typically use equations to relate volume estimates from photogrammetry to mass; however, most fail to identify the sources of error between the estimated and actual mass. Our objective was to identify the sources of error that prevent photogrammetric mass estimation from directly predicting actual mass, and develop a methodology to correct this issue...
2018: PloS One
https://www.readbyqxmd.com/read/29319815/chemical-analysis-and-simulated-pyrolysis-of-tobacco-heating-system-2-2-compared-to-conventional-cigarettes
#12
Xiangyu Li, Yanbo Luo, Xingyi Jiang, Hongfei Zhang, Fengpeng Zhu, Shaodong Hu, Hongwei Hou, Qingyuan Hu, Yongqiang Pang
Introduction: Tobacco Heating System 2.2 (THS 2.2, marketed as iQOS), is a heat-not-burn (HNB) tobacco product that has been successfully introduced to global markets. Despite its expanding market, few independent and systematic researches into THS 2.2 have been carried out to date. Methods: We tested a comprehensive list of total particulate matter (TPM), water, tar, nicotine, propylene glycol, glycerin, carbon monoxide, volatile organic compounds, aromatic amines, hydrogen cyanide, ammonia, N-nitrosamines, phenol, and polycyclic aromatic hydrocarbon under both ISO and HCI regimes...
January 8, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29319738/the-use-of-nanoparticles-in-wound-treatment-a-systematic-review
#13
Maria Michelle Pereira Silva, Maria Isis Freire de Aguiar, Andrea Bezerra Rodrigues, Maira Di Ciero Miranda, Michell Ângelo Marques Araújo, Isaura Letícia Tavares Palmeira Rolim, Angela Maria Alves E Souza
OBJECTIVE: To analyze the effects of nanoparticle-based dressings on the wound healing process in in vitro animals and human cells based on scientific evidence. METHOD: A systematic review of the literature in LILACS, PubMed and Science Direct databases. The articles were selected and evaluated for the level of evidence by the application of STROBE. RESULTS: The sample consisted of 12 articles. The application of the products occurred in surgical wounds, burns, infected wounds and gingival ulcers in laboratory animals, as well as in vitro tests, demonstrating that among other advantages, the nanoparticle-based dressings increased the healing speed, had good antibacterial capacity and were non cytotoxic agents...
January 8, 2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29315336/hyperphosphatemia-is-associated-with-high-mortality-in-severe-burns
#14
George Kuo, Cheng-Chia Lee, Shih-Yi Yang, Yen-Chang Hsiao, Shiow-Shuh Chuang, Su-Wei Chang, Kun-Hua Tu, Pei-Chun Fan, Ya-Chung Tian, Yung-Chang Chen, Chih-Hsiang Chang
INTRODUCTION: Phosphate level is often deranged during acute illness, regardless of the presence of kidney injury or not. A few studies described that hypophosphatemia may associated with outcome in patients admitted to the burn unit, but the literatures for hyperphosphatemia is limited. Our study aims to evaluate if hyperphosphatemia, one of the sign of severe tissue damage or kidney injury, will associate with mortality of patients with severe burns. MATERIALS AND METHODS: The study was a post hoc analysis of prospectively collected data from patients admitted to the burn unit between September 2006 and December 2011...
2018: PloS One
https://www.readbyqxmd.com/read/29305105/assessing-the-feasibility-of-implementing-low-cost-virtual-reality-therapy-during-routine-burn-care
#15
Cameron G Ford, Ellen M Manegold, Cameron L Randall, Ariel M Aballay, Christina L Duncan
Burn care often involves procedures that result in significant pain experiences for patients which, in turn, can lead to poorer physical and psychological health outcomes. Distraction and virtual reality (VR) are an effective adjunct to pharmacological interventions in reducing pain. Much of the research that has demonstrated efficacy for VR in burn care has involved expensive and extensive technology. Thus, identifying cost-effective, feasible, acceptable, and effective approaches to apply distraction within routine burn care is important...
January 2, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29302918/in-vivo-evaluation-of-bacterial-cellulose-acrylic-acid-wound-dressing-hydrogel-containing-keratinocytes-and-fibroblasts-for-burn-wounds
#16
Najwa Mohamad, Evelyn Yun Xi Loh, Mh Busra Fauzi, Min Hwei Ng, Mohd Cairul Iqbal Mohd Amin
The healing of wounds, including those from burns, currently exerts a burden on healthcare systems worldwide. Hydrogels are widely used as wound dressings and in the field of tissue engineering. The popularity of bacterial cellulose-based hydrogels has increased owing to their biocompatibility. Previous study demonstrated that bacterial cellulose/acrylic acid (BC/AA) hydrogel increased the healing rate of burn wound. This in vivo study using athymic mice has extended the use of BC/AA hydrogel by the addition of human epidermal keratinocytes and human dermal fibroblasts...
January 4, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29300328/the-human-exposure-potential-from-propylene-releases-to-the-environment
#17
REVIEW
David A Morgott
A detailed literature search was performed to assess the sources, magnitudes and extent of human inhalation exposure to propylene. Exposure evaluations were performed at both the community and occupational levels for those living or working in different environments. The results revealed a multitude of pyrogenic, biogenic and anthropogenic emission sources. Pyrogenic sources, including biomass burning and fossil fuel combustion, appear to be the primary contributors to atmospheric propylene. Despite a very short atmospheric lifetime, measurable levels could be detected in highly remote locations as a result of biogenic release...
January 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29297087/biobrane-dressing-for-paediatric-burns-in-singapore-a-retrospective-review
#18
Cong Fan, Chong Han Pek, Yong Chen Por, Gale Jue Shuang Lim
INTRODUCTION: The ideal burn dressing for children should aim to alleviate pain, decrease length of hospital stay and minimise complications, such as conversion and infection. The current literature is still inconclusive with regard to the gold standard burn dressing for the paediatric population. METHODS: We retrospectively reviewed children with superficial partial thickness burns admitted to our paediatric burn unit from January 2014 to April 2015. A total of 30 patients were included in our study, of which 13 had Biobrane dressing...
January 3, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29296762/whole-exome-sequencing-in-evaluation-of-patients-with-venous-thromboembolism
#19
Eun-Ju Lee, Daniel J Dykas, Andrew D Leavitt, Rodney M Camire, Eduard Ebberink, Pablo García de Frutos, Kavitha Gnanasambandan, Sean X Gu, James A Huntington, Steven R Lentz, Koen Mertens, Christopher R Parish, Alireza R Rezaie, Peter P Sayeski, Caroline Cromwell, Noffar Bar, Stephanie Halene, Natalia Neparidze, Terri L Parker, Adrienne J Burns, Anne Dumont, Xiaopan Yao, Cassius Iyad Ochoa Chaar, Jean M Connors, Allen E Bale, Alfred Ian Lee
Genetics play a significant role in venous thromboembolism (VTE), yet current clinical laboratory-based testing identifies a known heritable thrombophilia (factor V Leiden, prothrombin gene mutation G20210A, or a deficiency of protein C, protein S, or antithrombin) in only a minority of VTE patients. We hypothesized that a substantial number of VTE patients could have lesser-known thrombophilia mutations. To test this hypothesis, we performed whole-exome sequencing (WES) in 64 patients with VTE, focusing our analysis on a novel 55-gene extended thrombophilia panel that we compiled...
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295606/novel-application-of-cultured-epithelial-autografts-cea-with-expanded-mesh-skin-grafting-over-an-artificial-dermis-or-dermal-wound-bed-preparation
#20
Sadanori Akita, Kenji Hayashida, Hiroshi Yoshimoto, Masaki Fujioka, Chikako Senju, Shin Morooka, Gozo Nishimura, Nobuhiko Mukae, Kazuo Kobayashi, Kuniaki Anraku, Ryuichi Murakami, Akiyoshi Hirano, Masao Oishi, Shintaro Ikenoya, Nobuyuki Amano, Hiroshi Nakagawa
Cultured epithelial autografts (CEA) with highly expanded mesh skin grafts were used for extensive adult burns covering more than 30% of the total body surface area. A prospective study on eight patients assessed subjective and objective findings up to a 12-month follow-up. The results of wound healing for over 1:6 mesh plus CEA, gap 1:6 mesh plus CEA, and 1:3 mesh were compared at 3, 6, and 12 months using extensibility, viscoelasticity, color, and transepidermal water loss by a generalized estimating equation (GEE) or generalized linear mixed model (GLMM)...
December 25, 2017: International Journal of Molecular Sciences
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