keyword
MENU ▼
Read by QxMD icon Read
search

Phagocytic activity of neutrophils

keyword
https://www.readbyqxmd.com/read/29672626/engystol-reduces-onset-of-experimental-respiratory-syncytial-virus-induced-respiratory-inflammation-in-mice-by-modulating-macrophage-phagocytic-capacity
#1
Sabine Wronski, Julia Dannenmaier, Sabine Schild, Olaf Macke, Laura Müller, Yvonne Burmeister, Bernd Seilheimer, Meike Müller
BACKGROUND: Respiratory viruses such as respiratory syncytial virus (RSV) or rhinovirus are one of the major causes for respiratory tract infections causing common cold disease. Respiratory viral infections range from mild symptoms in adults to serious illness especially in the very young or elderly as well as patients suffering from lung diseases or being immunocompromised due to other reasons. Engystol (EGY-2) is a multicomponent, multitarget preparation consisting of Vincetoxicum hirundinaria and Sulfur in various dilutions...
2018: PloS One
https://www.readbyqxmd.com/read/29670351/cellular-interaction-of-a-layer-by-layer-based-drug-delivery-system-depending-on-material-properties-and-cell-types
#2
Mandy Brueckner, Steffen Jankuhn, Eva-Maria Jülke, Uta Reibetanz
Background: Drug delivery systems (DDS) and their interaction with cells are a controversial topic in the development of therapeutic concepts and approaches. On one hand, DDS are very useful for protected and targeted transport of defined dosages of active agents. On the other hand, their physicochemical properties such as material, size, shape, charge, or stiffness have a huge impact on cellular uptake and intracellular processing. Additionally, even identical DDS can undergo a completely diverse interaction with different cell types...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29664835/phagocytosis-by-fibrocytes-as-a-mechanism-to-decrease-bacterial-burden-and-increase-survival-in-sepsis
#3
Dalis Collins, Christopher Fry, Bethany B Moore, Jean A Nemzek
Fibrocytes are unique cells with innate and adaptive immune functions, but these mechanisms have not been fully explored. The aim of this study was to explain the mechanism by which adoptive transfer of exogenous fibrocytes improved bacterial clearance and increased sepsis survival. Initial flow cytometry-based, in vitro assays demonstrated phagocytosis by fibrocytes and intracellular bacterial killing was confirmed by direct plating of cell lysates after exposure to live bacteria. Intravenous adoptive transfer of fibrocytes at the time of cecal ligation and puncture (CLP) or two hours after CLP in mice increased survivability...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29652311/-inflammatory-factors-and-immunophenotypes-in-adjustment-disorders
#4
T P Klyushnik, V B Nikitina, L V Androsova, T P Vetlugina, S A Zozulya, M M Aksenov, N A Bokhan
AIM: To identify inflammatory and autoimmune markers (enzymatic activity of leukocyte elastase (LE), functional α1-proteinase inhibitor (α1-PI), the level of autoantibodies to neurospecific antigens S100b and myelin basic protein (MBP)) as well as phagocytic activity of blood neutrophils of patients with disorders of adaptation, to determine certain immunophenotypes and analyze their possible relationships with disease characteristics. MATERIAL AND METHODS: The study included 40 patients with adaptation disorders, mostly women...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29618478/nadph-oxidase-activation-regulates-apoptotic-neutrophil-clearance-by-murine-macrophages
#5
Juhi Bagaitkar, Jing Huang, Melody Yue Zeng, Nancy K Pech, Darlene A Monlish, Lizet J Perez-Zapata, Irina Miralda, Laura G Schuettpelz, Mary C Dinauer
The phagocyte NADPH oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that have both antimicrobial and immunoregulatory functions. Inactivating mutations in NADPH oxidase alleles cause chronic granulomatous disease (CGD), characterized by enhanced susceptibility to life-threatening microbial infections and inflammatory disorders, and hypomorphic NADPH oxidase alleles are associated with autoimmunity. Impaired apoptotic cell (AC) clearance is implicated as an important contributing factor in chronic inflammation and autoimmunity, but the role of NADPH oxidase-derived ROS in this process is incompletely understood...
April 4, 2018: Blood
https://www.readbyqxmd.com/read/29605448/neutrophils-and-redox-stress-in-the-pathogenesis-of-autoimmune-disease
#6
REVIEW
Laurence Glennon-Alty, Angela P Hackett, Elinor A Chapman, Helen L Wright
Polymorphonuclear leukocytes, or neutrophils, are specialist phagocytic cells of the innate immune system. Their primary role is host defence against micro-organisms, which they kill via phagocytosis, followed by release of reactive oxygen species (ROS) and proteolytic enzymes within the phagosome. ROS are generated via the action of the NADPH oxidase (also known as NOX2), in a process termed the 'Respiratory Burst'. This process consumes large amounts of oxygen, which is converted into the highly-reactive superoxide radical O2 - and H2 O2 ...
March 29, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29602776/mitocryptides-from-human-mitochondrial-dna-encoded-proteins-activate-neutrophil-formyl-peptide-receptors-receptor-preference-and-signaling-properties
#7
Michael Gabl, Martina Sundqvist, Andre Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Phagocytic neutrophils express formyl peptide receptors (FPRs; FPR1 and FPR2) that distinctly recognize peptides starting with an N-formylated methionine (fMet). This is a hallmark of bacterial metabolism; similar to prokaryotes, the starting amino acid in synthesis of mitochondrial DNA-encoded proteins is an fMet. Mitochondrial cryptic peptides (mitocryptides; MCTs) with an N-terminal fMet could be identified by our innate immune system; however, in contrast to our knowledge about bacterial metabolites, very little is known about the recognition profiles of MCTs...
March 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29572472/diversity-of-innate-immune-cell-subsets-across-spatial-and-temporal-scales-in-an-eae-mouse-model
#8
Céline Caravagna, Alexandre Jaouën, Sophie Desplat-Jégo, Keith K Fenrich, Elise Bergot, Hervé Luche, Pierre Grenot, Geneviève Rougon, Marie Malissen, Franck Debarbieux
In both multiple sclerosis and its model experimental autoimmune encephalomyelitis (EAE), the extent of resident microglia activation and infiltration of monocyte-derived cells to the CNS is positively correlated to tissue damage. To address the phenotype characterization of different cell subsets, their spatio-temporal distributions and contributions to disease development we induced EAE in Thy1-CFP//LysM-EGFP//CD11c-EYFP reporter mice. We combined high content flow cytometry, immunofluorescence and two-photon imaging in live mice and identified a stepwise program of inflammatory cells accumulation...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29564980/diclofenac-1-3-4-oxadiazole-derivatives-biology-oriented-drug-synthesis-biods-in-search-of-better-non-steroidal-non-acid-antiinflammatory-agents
#9
Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan, Shakil Ahmed, Abeer Raza, Shahnaz Perveen
BACKGROUND: Inflammation is defined as the response of immune system cells to damaged or injured tissues The major symptoms of inflammation include increased blood flow, cellular influx, edema, elevated cellular metabolism, reactive oxygen species (ROS) nitric oxide (NO) and vasodilation. This normally protective mechanism against harmful agents when this normal mechanism becomes dysregulated that can cause serious illnesses including ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthritis, sepsis, and chronic pulmonary inflammation ...
March 21, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29551862/evaluation-of-peripheral-neutrophil-functions-in-aggressive-periodontitis-patients-and-their-family-members-in-indian-population-an-assessment-of-neutrophil-chemotaxis-phagocytosis-and-microbicidal-activity
#10
Rahul Suresh Bhansali, Ramreddy Krishnarao Yeltiwar, Kishore Bhat
Background: Association of neutrophil function abnormalities with localized aggressive periodontitis (LAP) has been reported in Indian population. There are no published studies on the familial aggregation of aggressive periodontitis (AP) and neutrophil function abnormalities associated with it in Indian population. The present study aimed to assess neutrophil chemotaxis, phagocytosis, and microbicidal activity in AP patients and their family members of Indian origin, who may or may not be suffering from AP...
November 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29539422/extracellular-neutrophil-proteases-are-efficient-regulators-of-il-1-il-33-and-il-36-cytokine-activity-but-poor-effectors-of-microbial-killing
#11
Danielle M Clancy, Graeme P Sullivan, Hannah B T Moran, Conor M Henry, Emer P Reeves, Noel G McElvaney, Ed C Lavelle, Seamus J Martin
Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil proteases play an important role in the coordination and escalation of inflammatory reactions, but how this is achieved has been obscure. IL-1 family cytokines are important initiators of inflammation and are typically released via necrosis but require proteolytic processing for activation...
March 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29528132/platelet-leucocyte-aggregation-is-augmented-in-cirrhosis-and-further-increased-by-platelet-transfusion
#12
S Støy, V C Patel, J P Sturgeon, G K Manakkat Vijay, T Lisman, W Bernal, D L Shawcross
BACKGROUND: Thrombocytopenia and circulating dysfunctional immune cells are commonly observed in patients with cirrhosis. Platelets may form complexes with neutrophils, monocytes and T cells modulating their function. We recently reported increased frequencies of platelet-complexed neutrophils in cirrhosis with evidence of neutrophil activation upon contact with healthy platelets in vitro. Whether this occurs in vivo following platelet transfusion and contributes to systemic inflammation and endothelial activation is unknown...
March 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29520273/extracellular-vesicles-released-from-mycobacterium-tuberculosis-infected-neutrophils-promote-macrophage-autophagy-and-decrease-intracellular-mycobacterial-survival
#13
Violeta D Alvarez-Jiménez, Kahiry Leyva-Paredes, Mariano García-Martínez, Luis Vázquez-Flores, Víctor Gabriel García-Paredes, Marcia Campillo-Navarro, Israel Romo-Cruz, Víctor Hugo Rosales-García, Jessica Castañeda-Casimiro, Sirenia González-Pozos, José Manuel Hernández, Carlos Wong-Baeza, Blanca Estela García-Pérez, Vianney Ortiz-Navarrete, Sergio Estrada-Parra, Jeanet Serafín-López, Isabel Wong-Baeza, Rommel Chacón-Salinas, Iris Estrada-García
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the lungs, macrophages and neutrophils are the first immune cells that have contact with the infecting mycobacteria. Neutrophils are phagocytic cells that kill microorganisms through several mechanisms, which include the lytic enzymes and antimicrobial peptides that are found in their lysosomes, and the production of reactive oxygen species. Neutrophils also release extracellular vesicles (EVs) (100-1,000 nm in diameter) to the extracellular milieu; these EVs consist of a lipid bilayer surrounding a hydrophilic core and participate in intercellular communication...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29518426/cd40-ligand-deficiency-causes-functional-defects-of-peripheral-neutrophils-that-are-improved-by-exogenous-ifn-%C3%AE
#14
Otavio Cabral-Marques, Tabata Takahashi França, Ashraf Al-Sbiei, Lena Friederike Schimke, Taj Ali Khan, Claudia Feriotti, Tania Alves da Costa, Osvaldo Reis Junior, Cristina Worm Weber, Janaíra Fernandes Ferreira, Fabiola Scancetti Tavares, Claudia Valente, Regina Sumiko Watanabe Di Gesu, Asif Iqbal, Gabriela Riemekasten, Gustavo Pessini Amarante-Mendes, José Alexandre Marzagão Barbuto, Beatriz Tavares Costa-Carvalho, Paulo Vitor Soeiro Pereira, Maria J Fernandez-Cabezudo, Vera Lucia Garcia Calich, Luigi D Notarangelo, Troy R Torgerson, Basel K Al-Ramadi, Hans D Ochs, Antonio Condino-Neto
BACKGROUND: Patients with X-linked Hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) deficiency often present episodic, cyclic or chronic neutropenia, suggesting abnormal neutrophil development in the absence of CD40L-CD40 interaction. However, even when not neutropenic and despite immunoglobulin (Ig) replacement therapy, CD40L-deficient patients are susceptible to life-threatening infections caused by opportunistic pathogens, suggesting impaired function of phagocytes and the need of novel therapeutic approaches...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29515586/the-neutrophil-s-choice-phagocytose-vs-make-neutrophil-extracellular-traps
#15
REVIEW
Angelo A Manfredi, Giuseppe A Ramirez, Patrizia Rovere-Querini, Norma Maugeri
Neutrophils recognize particulate substrates of microbial or endogenous origin and react by sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps (NETs) outside the cell, thus modifying and alerting the environment and bystander leukocytes. The signals that determine the choice between phagocytosis and the generation of NETs are still poorly characterized. Neutrophils that had phagocytosed bulky particulate substrates, such as apoptotic cells and activated platelets, appear to be "poised" in an unresponsive state...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29511657/effect-of-rapid-weight-loss-and-glutamine-supplementation-on-immunosuppression-of-combat-athletes-a-double-blind-placebo-controlled-study
#16
Aline C C Tritto, Mariane T Amano, Maria E De Cillo, Vinicius A Oliveira, Sandro H Mendes, Caroline Yoshioka, Hamilton Roschel, Niels Olsen S Camara, Bruno Gualano, Guilherme G Artioli
The role of plasma glutamine concentration and glutamine supplementation on immunosuppression was investigated in combat athletes. Twenty-three male athletes were randomly assigned to receive glutamine (21 g/day, n=12) or placebo (ovalbumin, n=11) for 10 days. Six athletes who did not lose weight served as controls. Athletes were assessed 21 days before (-21d), 1 day before (-1d) and 5 days after (+5d) a competition. Weight reduction was similar between glutamine (-8.2%± 4.1%) and placebo (-8.5%±2.4%) and negligible in control (-0...
February 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29486352/histological-and-transcriptomic-responses-of-two-immune-organs-the-spleen-and-head-kidney-in-nile-tilapia-oreochromis-niloticus-to-long-term-hypersaline-stress
#17
Chang Xu, Erchao Li, Yantong Suo, Yujie Su, Minghui Lu, Qun Zhao, Jian G Qin, Liqiao Chen
Hyperosmotic stress can adversely affect fish immunity, but little is known about the histological and transcriptomic responses of immune organs in fish in a hyperosmotic environment. This study evaluated the effects of long-term hypersaline conditions (16‰) on the growth, histology and transcriptomics of the two main immune organs, the spleen and head kidney, in Nile tilapia Oreochromis niloticus relative to those reared in freshwater for eight weeks. No differences in weight gain and specific growth rate were found between fish reared under these two salinities...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29477577/similarities-and-differences-between-the-responses-induced-in-human-phagocytes-through-activation-of-the-medium-chain-fatty-acid-receptor-gpr84-and-the-short-chain-fatty-acid-receptor-ffa2r
#18
Martina Sundqvist, Karin Christenson, André Holdfeldt, Michael Gabl, Jonas Mårtensson, Lena Björkman, Regis Dieckmann, Claes Dahlgren, Huamei Forsman
GPR84 is a recently de-orphanized member of the G-protein coupled receptor (GPCR) family recognizing medium chain fatty acids, and has been suggested to play important roles in inflammation. Due to the lack of potent and selective GPR84 ligands, the basic knowledge related to GPR84 functions is very limited. In this study, we have characterized the GPR84 activation profile and regulation mechanism in human phagocytes, using two recently developed small molecules that specifically target GPR84 agonistically (ZQ16) and antagonistically (GLPG1205), respectively...
February 22, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29477410/role-of-heme-oxygenase-1-in-potentiation-of-phagocytic-activity-of-macrophages-by-taurine-chloramine-implications-for-the-resolution-of-zymosan-a-induced-murine-peritonitis
#19
Wonki Kim, Seung Hyeon Kim, Jeong-Hoon Jang, Chaekyun Kim, Kyeojin Kim, Young-Ger Suh, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Surh
Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrophils under inflammatory conditions. In the present study, we investigated the effect of TauCl on resolution of acute inflammation caused by fungal infection using a zymosan A-induced murine peritonitis model...
February 9, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29476818/immune-defense-of-emodin-enriched-diet-in-clarias-batrachus-against-aeromonas-hydrophila
#20
Ramasamy Harikrishnan, Sundaram Jawahar, Subramanian Thamizharasan, Bilal Ahmad Paray, Mohammad K Al-Sadoon, Chellam Balasundaram
This study investigates the effect of emodin enriched diet on growth, hematology, and immune response in walking catfish, Clarias batrachus against Aeromonas hydrophila. The basal (control) diet supplemented with emodin at 0.0, 0.1, 0.2, or 0.4 g kg-1 was fed to the experimental groups for a period of four weeks. Feeding infected fish with 0.2 g kg-1 and 0.4 g kg-1 emodin enriched diets resulted in an overall weight gain, enhanced PER and FCR when compared to other diets. The survival rates were 98...
February 21, 2018: Fish & Shellfish Immunology
keyword
keyword
63512
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"