Keigo Iemitsu, Rieko Sakai, Akira Maeda, Katarzyna Gadomuska, Shuhei Kogata, Daiki Yasufuku, Jun Matsui, Kazunori Masahata, Masafumi Kamiyama, Hiroshi Eguchi, Soichi Matsumura, Yoichi Kakuta, Hiroshi Nagashima, Hiroomi Okuyama, Shuji Miyagawa
OBJECTIVE: Innate immunity plays a vital role in xenotransplantation. A CD47 molecule, binding to the SIRPα expressed on monocyte/macrophage cells, can suppress cytotoxicity. Particularly, the SIRPα contains ITIM, which delivers a negative signal. Our previous study demonstrated that the binding between CL-P1 and surfactant protein-D hybrid (CL-SP-D) with SIRPα regulates macrophages' phagocytic activity. In this study, we examined the effects of human CD47 and CL-SP-D expression on the inhibition of xenograft rejection by neutrophils in swine endothelial cells (SECs)...
March 5, 2024: Transplant Immunology