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Inflammatory aortic aneurism

Domenico Milite, Fabio Pilon, Alessandra Ferrari, Daniela Danieli, Alessandro Desole
We report a case of epithelioid angiosarcoma of the abdominal aortic wall after endovascular treatment for abdominal aortic aneurysm (EVAR). A 60-year-old male, treated 7 years before with EVAR, presented with abdominal back pain, general fatigue, and fever. It was assumed to be a graft infection with periaortic tissue compatible with an inflammatory reaction. The endograft was therefore completely removed and a Dacron silver aorto-bisiliac graft was implanted. After a few days the patient worsened, the angio-computed tomography scan showed a progressive increase of the periaortic mass and numerous small nodules in the abdomen were also detected...
August 2016: Annals of Vascular Surgery
Olivier Espitia, Maxime Samson, Thomas Le Gallou, Jérôme Connault, Cedric Landron, Christian Lavigne, Cristina Belizna, Julie Magnant, Claire de Moreuil, Pascal Roblot, François Maillot, Elisabeth Diot, Patrick Jégo, Cécile Durant, A Masseau, Jean-Marie Brisseau, Pierre Pottier, Alexandra Espitia-Thibault, Anabele Dos Santos, François Perrin, Mathieu Artifoni, Antoine Néel, Julie Graveleau, Philippe Moreau, Hervé Maisonneuve, Georges Fau, Jean-Michel Serfaty, Mohamed Hamidou, Christian Agard
OBJECTIVES: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. METHODS: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >2mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared...
June 2016: Autoimmunity Reviews
Luigi Fabrizio Rodella, Rita Rezzani, Francesca Bonomini, Michele Peroni, Marco Angelo Cocchi, Lena Hirtler, Stefano Bonardelli
To date, the pathogenesis of abdominal aortic aneurism (AAA) still remains unclear. As such, the aim of this study was to evaluate changes of the aortic structure during AAA. We analysed the microscopic frame of vessels sections, starting from the primum movens leading to abnormal dilatation. AAA samples were collected and processed through various staining methods (Verhoeff-Van Gieson, Masson Goldner, Sirius Red). Subsequently, the vessel morphology and collagenic web of the tunica media and adventitia were determined and the amount of type I and type III collagen was measured...
April 2016: Acta Histochemica
Derek Lacey, Peter Hickey, Benedicta D Arhatari, Lorraine A O'Reilly, Leona Rohrbeck, Helen Kiriazis, Xiao-Jun Du, Philippe Bouillet
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic inflammatory diseases that together affect 2-3% of the population. RA and AS predominantly involve joints, but heart disease is also a common feature in RA and AS patients. Here we have studied a new spontaneous mutation that causes severe polyarthritis in bone phenotype spontaneous mutation 1 (BPSM1) mice. In addition to joint destruction, mutant mice also develop aortic root aneurism and aorto-mitral valve disease that can be fatal depending on the genetic background...
August 4, 2015: Proceedings of the National Academy of Sciences of the United States of America
Andrea Benedetto Galosi, Carlo Grilli Cicilioni, Giulia Sbrollini, Andrea Angelini, Guevar Maselli, Luciano Carbonari
We report a case of Inflammatory Abdominal Aortic Aneurysm (IAAA) producing bilateral hydro-ureteronephrosis. A 74-year-old patient presented to urologist office for bilateral hydronephrosis detected by kidney and bladder ultrasound (US). Patient reported lower urinary tract symptoms and inconstant and slight low back pain irradiated to inguinal region dating 3 weeks. Renal function, urine analysis and abdominal examination were normal. However the repeated ultrasound in the urologist office revealed abdominal aortic aneurism extended to iliac vessels...
December 2014: Archivio Italiano di Urologia, Andrologia
Yuekang Xu, Petra Lindemann, Javier Vega-Ramos, Jian-Guo Zhang, Jose A Villadangos
The cysteine protease inhibitor cystatin C is thought to be secreted by most cells and eliminated in the kidneys, so its concentration in plasma is diagnostic of kidney function. Low extracellular cystatin C is linked to pathologic protease activity in cancer, arthritis, atherosclerosis, aortic aneurism, and emphysema. Cystatin C forms non-inhibitory dimers and aggregates by a mechanism known as domain swapping, a property that reportedly protects against Alzheimer disease but can also cause amyloid angiopathy...
April 4, 2014: Journal of Biological Chemistry
M Peyre, C Laroche, C Etchecopar, P Brosset
INTRODUCTION: Kawasaki disease (KD) is the most common cause of acquired heart disease in developed countries. Ten percent of patients with KD develop coronary aneurism. Ten percent of patients treated with intravenous immunoglobulin (IgIV) have persistent coronary dilatations, which sustains the search for new therapies. We describe 2 cases of refractory KD and discuss the therapeutic options. CLINICAL REPORT: A 3-year-old child and a 3-month-old infant had refractory KD...
July 2013: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Stephanie Schulte, Jiusong Sun, Peter Libby, Lindsey Macfarlane, Chongxiu Sun, Marco Lopez-Ilasaca, Guo-Ping Shi, Galina K Sukhova
An imbalance between cysteinyl cathepsins and their principal endogenous inhibitor cystatin C (CystC) may favor proteolysis in the pathogenesis of human abdominal aortic aneurysms (AAA), yet a direct role of CystC in AAA remains unproven. This study used CystC and apolipoprotein E (ApoE) compound mutant (CystC(-/-)ApoE(-/-)) mice to examine directly the role of cysteine protease/protease inhibitor imbalance in AAA formation in angiotensin II-induced AAA. CystC-deficiency increased lumenal diameter and lesion size compared with control mice...
July 2010: American Journal of Pathology
Przemysław P Szyber, Artur Pupka, Dariusz Janczak, Stanisław Pawłowski, Artur Ruciński, Piotr Szyber
THE PURPOSE: Every foreign body injected into an organism causes an inflammatory condition. Among other things leukocytes take part in it. The healing of a vascular prosthesis means gradual subsiding of an inflammatory condition. The process can be monitored with the series of scintigraphy following decrease of an area of concentrating of Technetium-labeled leukocytes. The purpose of work was an appraisal of the healing of both types of prostheses in cases of patients operated because of aneurism of abdominal aorta...
2009: Polimery W Medycynie
M El Kouache, L Marmade, M Tribak, S Moughil, A Bensouda, J Filal, A Benomar, M-T Ouazzani, S Abir, M-H Benomar
Aortic regurgitation caused by non-specific aortitis is relatively rare, and is now considered as an important risk factor related to mortality. Aortic valve replacement surgery is the only curative treatment. Aneurismal dilatation of the ascending thoracic aorta associated with aortic regurgitation is a rare involvement in Takayasu, there are many difficult problems in surgical treatment of this lesion, because of its inflammatory nature, so steroid therapy before and after surgery is therefore vital. We report the cases of tow young Moroccans women (32-35 years-old) with an ascending aortic aneurism associated to aortic insufficiency...
August 2008: Annales de Cardiologie et D'angéiologie
Ming-fang Liao, Zai-ping Jing, Jun-min Bao, Zhi-qing Zhao, Zhi-jun Mei, Qing-shen Lu, Xiang Feng, Rui Feng, Su-zen Zhang, Xiao-yan Li
BACKGROUND: Nitric oxide (NO) is an important mediator in the pathophysiology of many vascular diseases. However, the definite role of NO in human abdominal aortic aneurysm (AAA) formation is unclear. The aim of this study was to investigate production of NO and expression of inducible nitric oxide synthase (iNOS), and their possible role in AAA. METHODS: A total of 28 patients with AAA, 10 healthy controls, and 8 patients with arterial occlusive disease were enrolled into this study...
February 20, 2006: Chinese Medical Journal
P Bourlet, J M Garcier, A Alfidja, E Lipiecka, T Chahid, C Privat, A Ravel, L Boyer
The purpose was to illustrate that single or multirow spiral CT angiography has become the main modality for the examination of the abdominal aorta. Our multidisciplinary group investigates weekly 15 abdominal aortas, with a single slice spiral CT since 1995, and a 4 row detector spiral CT since 1999. CT scans protocols and parameters optimization for the 2 CT systems are described. Indications and results of CT to investigate the various abdominal aortic diseases are illustrated and discussed: aneurisms (pretherapeutic staging, selection of indications of endovascular stent-grafting); obstructive aorto-arteriopathies (pretherapeutic staging, follow up after endovascular revascularization); dissection (diagnosis, pretherapeutic staging, follow up); inflammatory diseases; normal patterns and principal complications after surgery...
January 2005: Journal de Radiologie
J M Casas, M V Acha
Giant cell arteritis is a vasculitis of large and medium size arteries, especially those of the aortic arch with an extracranial distribution, but also the aorta and some of its larger branches. It is characterised by the presence of mononuclear inflammatory infiltrates close to the internal elastic lamina formed by lymphocytes and macrophages, which in slightly more than 50% of the cases contain multinucleate giant cells. The morbidity associated with this disease is related to phenomena of distal ischemia to the luminal stenosis of the inflamed arteries, and to a lesser extent to the formation of aneurisms due to the weakening of the arterial wall...
January 2003: Anales del Sistema Sanitario de Navarra
E Hachulla, J P Bérégi
Aortitis can be a component of a variety of diseases, such as Takayasu arteritis, giant cell arteritis, Behçet's syndrome, Cogan's syndrome, spondylarthropathies, rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, Erdheim-Chester's disease and a variety of infectious processes like syphilis, Salmonella and others. The presentation is variable: aortic valve regurgitation, aneurysm, dissection, stenosis of the aorta or its initial branches. Sometimes systemic manifestations are at first presentation like fever or inflammatory syndrome...
October 2001: Journal des Maladies Vasculaires
M Gargiulo, A Stella, M Caputo, S Brusori, L Pedrini, S Tarantini, T Curti
The sub-renal abnormalities of the lower vena cava (LVC) (left LVC, double LVC) are determined by a deterioration of the alteration process of supra-cardinal veins. Though they are rare, it is necessary to look for them during surgery of abdominal aorta in order to lower the risk of iatrogenic venous injuries. You will find below the description of six cases of sub-renal lower vena cava abnormality (3 double LVC, 3 left LVC) associated with an abdominal aorta aneurism (4 non specific aneurisms, 2 inflammations ones) as well as the diagnostic aspects and the technical issues they cause during the reconstruction of a non specific and inflammation aneurism of the abdominal aorta...
July 1993: Phlébologie
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