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Semantic dementia

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https://www.readbyqxmd.com/read/28625933/experience-for-caregivers-of-dependent-elderly-persons-with-dementia
#1
Alexandre Vallée, Jean-Noël Vallée
Dependent elderly people with dementia require constant attention and significant care most of which are provided by family caregivers. The aim of our study is to highlight the feelings of caregivers of elderly with dementia and dependent. This qualitative study based on grounded theory method with semi-structured interviews with caregivers of dependent elderly. A comparative analysis of interviews to interview was conducted to identify themes, from the codes compared on a semantic level. 39 caregivers were interviewed until data saturation...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28625695/arbitrary-and-semantic-associations-in%C3%A2-subjective-memory-impairment-and-amnestic-mild-cognitive-impairment-among-taiwanese-individuals-a-cross-sectional-study
#2
Hsin-Te Chang, Ta-Fu Chen, Ting-Wen Cheng, Ya-Mei Lai, Mau-Sun Hua
BACKGROUND/PURPOSE: Researchers have recently proposed a preclinical stage of dementia of Alzheimer's type (DAT), referred to as subjective memory impairment (SMI), with the aim of developing methods for the early detection of DAT and subsequent intervention. It has been proposed that the objective memory functions of individuals with SMI are normal; however, arbitrary and semantic associations are both used to describe the processes of memory. No previous studies have investigated these processes among individuals with SMI...
June 15, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28624827/qualitative-assessment-of-verbal-fluency-performance-in-frontotemporal-dementia
#3
Esther van den Berg, Lize C Jiskoot, Mariëlle J H Grosveld, John C van Swieten, Janne M Papma
BACKGROUND/AIMS: Verbal fluency is impaired in patients with frontotemporal dementia (FTD) and primary progressive aphasia (PPA). This study explored qualitative differences in verbal fluency (clustering of words, switching between strategies) between FTD and PPA variants. METHODS: Twenty-nine patients with behavioral variant FTD (bvFTD) and 50 with PPA (13 nonfluent/agrammatic, 14 semantic, and 23 logopenic) performed a semantic and letter fluency task. Clustering (number of multiword strings) and switching (number of transitions between clustered and nonclustered words) were recorded by two independent raters...
June 17, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28624681/semantic-word-category-processing-in-semantic-dementia-and-posterior-cortical-atrophy
#4
Zubaida Shebani, Karalyn Patterson, Peter J Nestor, Lara Z Diaz-de-Grenu, Kate Dawson, Friedemann Pulvermüller
There is general agreement that perisylvian language cortex plays a major role in lexical and semantic processing; but the contribution of additional, more widespread, brain areas in the processing of different semantic word categories remains controversial. We investigated word processing in two groups of patients whose neurodegenerative diseases preferentially affect specific parts of the brain, to determine whether their performance would vary as a function of semantic categories proposed to recruit those brain regions...
April 29, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28593829/communication-behaviors-associated-with-successful-conversation-in-semantic-variant-primary-progressive-aphasia
#5
Cathleen Taylor-Rubin, Karen Croot, Emma Power, Sharon A Savage, John R Hodges, Leanne Togher
BACKGROUND: Primary progressive aphasia (PPA) affects a range of language and cognitive domains that impact on conversation. Little is known about conversation breakdown in the semantic variant of PPA (svPPA, also known as semantic dementia). This study investigates conversation of people with svPPA. METHODS: Dyadic conversations about everyday activities between seven individuals with svPPA and their partners, and seven control pairs were video recorded and transcribed...
June 8, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28592456/csf-sapp%C3%AE-ykl-40-and-neurofilament-light-in-frontotemporal-lobar-degeneration
#6
Daniel Alcolea, Eduard Vilaplana, Marc Suárez-Calvet, Ignacio Illán-Gala, Rafael Blesa, Jordi Clarimón, Albert Lladó, Raquel Sánchez-Valle, José L Molinuevo, Guillermo García-Ribas, Yaroslau Compta, María José Martí, Gerard Piñol-Ripoll, Guillermo Amer-Ferrer, Aina Noguera, Ana García-Martín, Juan Fortea, Alberto Lleó
OBJECTIVE: To analyze the clinical utility of 3 CSF biomarkers and their structural imaging correlates in a large cohort of patients with different dementia and parkinsonian syndromes within the spectrum of frontotemporal lobar degeneration (FTLD). METHODS: We analyzed 3 CSF biomarkers (YKL-40, soluble β fragment of amyloid precursor protein [sAPPβ], neurofilament light [NfL]) and core Alzheimer disease (AD) biomarkers (β-amyloid1-42, total tau, phosphorylated tau) in patients with FTLD-related clinical syndromes (n = 159): behavioral variant of frontotemporal dementia (n = 68), nonfluent (n = 23) and semantic (n = 19) variants of primary progressive aphasia, progressive supranuclear palsy (n = 28), and corticobasal syndrome (n = 21)...
June 7, 2017: Neurology
https://www.readbyqxmd.com/read/28579952/brain-network-for-the-core-deficits-of-semantic-dementia-a-neural-network-connectivity-behavior-mapping-study
#7
Yan Chen, Keliang Chen, Junhua Ding, Yumei Zhang, Qing Yang, Yingru Lv, Qihao Guo, Zaizhu Han
Individuals with semantic dementia (SD) typically suffer from selective semantic deficits due to degenerative brain atrophy. Although some brain regions have been found to be correlated with the semantic impairments of SD patients, it is unclear if the damage is actually responsible for SD patients' semantic disorders because these findings were primarily obtained by examining the roles of local individual regions themselves without considering the influence of other regions that are functionally or structurally connected to the local individual regions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28579383/clinical-and-biological-phenotypes-of-frontotemporal-dementia-perspectives-for-disease-modifying-therapies
#8
S Gazzina, M A Manes, A Padovani, B Borroni
Frontotemporal Dementia (FTD) is a progressive neurodegenerative condition which encompasses a group of clinically, neuropathologically and genetically heterogeneous disorders characterized by selective involvement of the frontal and temporal lobes. FTD is characterized by changes in behaviour and personality, frontal executive deficits and language dysfunction. Different phenotypes have been defined on the basis of presenting clinical symptoms, behavioural variants of FTD (bvFTD) and primary progressive aphasia (PPA), which includes nonfluent/agrammatic variant PPA (avPPA) and semantic variant PPA (svPPA)...
June 1, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28549937/is-learning-episodic-memory-distinct-cognitive-and-neuroanatomic-correlates-of-immediate-recall-during-learning-trials-in-neurologically-normal-aging-and-neurodegenerative-cohorts
#9
K B Casaletto, G Marx, S Dutt, J Neuhaus, R Saloner, L Kritikos, B Miller, J H Kramer
Although commonly interpreted as a marker of episodic memory during neuropsychological exams, relatively little is known regarding the neurobehavior of "total learning" immediate recall scores. Medial temporal lobes are clearly associated with delayed recall performances, yet immediate recall may necessitate networks beyond traditional episodic memory. We aimed to operationalize cognitive and neuroanatomic correlates of total immediate recall in several aging syndromes. Demographically-matched neurologically normal adults (n=91), individuals with Alzheimer's disease (n=566), logopenic variant primary progressive aphasia (PPA) (n=34), behavioral variant frontotemporal dementia (n=97), semantic variant PPA (n=71), or nonfluent/agrammatic variant PPA (n=39) completed a neurocognitive battery, including the CVLT-Short Form trials 1-4 Total Immediate Recall; a majority subset also completed a brain MRI...
May 23, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28548549/semantic-verbal-fluency-impairment-is-detectable-in-patients-with-subjective-cognitive-decline
#10
Tomas Nikolai, Ondrej Bezdicek, Hana Markova, Hana Stepankova, Jiri Michalec, Miloslav Kopecek, Monika Dokoupilova, Jakub Hort, Martin Vyhnalek
Patients with subjective cognitive decline (SCD) are at higher risk for conversion to dementia due to Alzheimer's disease (AD). Semantic verbal fluency (SVF) seems to be impaired in the early stages of AD. The goal of the present study was to identify the discriminative potential of verbal fluency (VF) in patients with SCD to show if very early signs of cognitive decline may be detected in SCD. We examined 93 normal controls (NC) and 61 participants with SCD. Each participant was administered a comprehensive neuropsychological battery...
May 26, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28532703/reading-difficulties-in-primary-progressive-aphasia-in-a-regular-language-speaking-cohort-of-patients
#11
Jordi A Matías-Guiu, Fernando Cuetos, María Nieves Cabrera-Martín, María Valles-Salgado, Teresa Moreno-Ramos, José Luis Carreras, Jorge Matías-Guiu
Reading impairment is an important feature in Primary Progressive Aphasia (PPA). The Spanish orthography entails completely regular spelling to sound correspondences, so reading disorders may be different to English. In the current study, reading, phonological and semantic abilities of 35 patients with the three variants of PPA, and 13 healthy volunteers were assessed. Brain metabolism was concomitantly obtained from each participant using (18)F-fluorodeoxyglucose positron emission tomography imaging. Two main patterns of impairment were identified: difficulties in nonwords reading with preservation of exception words in agrammatic and logopenic aphasia, and the inverse pattern in semantic dementia...
May 19, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28509343/the-influence-of-vascular-risk-factors-on-cognitive-function-in-early-parkinson-s-disease
#12
Maxime Doiron, Mélanie Langlois, Nicolas Dupré, Martine Simard
OBJECTIVES: Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. METHODS: A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1...
May 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28494819/mild-cognitive-impairment-in-parkinson-s-disease-clustering-and-switching-analyses-in-verbal-fluency-test
#13
Iván Galtier, Antonieta Nieto, Jesús N Lorenzo, José Barroso
OBJECTIVES: Mild cognitive impairment is common in non-demented Parkinson disease patients (PD-MCI) and is considered as a risk factor for dementia. Executive dysfunction has been widely described in PD and the Verbal Fluency Tests (VFT) are often used for executive function assessment in this pathology. The Movement Disorder Society (MDS) published guidelines for PD-MCI diagnosis in 2012. However, no investigation has focused on the qualitative analysis of VFT in PD-MCI. The aim of this work was to study the clustering and switching strategies in VFT in PD-MCI patients...
May 12, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28481569/cognitive-modeling-as-an-interface-between-brain-and-behavior-measuring-the-semantic-decline-in-mild-cognitive-impairment
#14
Brendan T Johns, Vanessa Taler, David B Pisoni, Martin R Farlow, Ann Marie Hake, David A Kareken, Frederick W Unverzagt, Michael N Jones
Mild cognitive impairment (MCI) is characterised by subjective and objective memory impairment in the absence of dementia. MCI is a strong predictor for the development of Alzheimer's disease, and may represent an early stage in the disease course in many cases. A standard task used in the diagnosis of MCI is verbal fluency, where participants produce as many items from a specific category (e.g., animals) as possible. Verbal fluency performance is typically analysed by counting the number of items produced...
May 8, 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28472447/actigraphic-sleep-duration-and-fragmentation-in-older-women-associations-with-performance-across-cognitive-domains
#15
Adam P Spira, Katie L Stone, Susan Redline, Kristine E Ensrud, Sonia Ancoli-Israel, Jane A Cauley, Kristine Yaffe
Study Objectives: To determine the association of actigraphic sleep duration and fragmentation with cognition in community-dwelling older women. Methods: We studied 782 women (mean age = 87.4) of varied cognitive status from the Study of Osteoporotic Fractures who completed wrist actigraphy and the 3MS, California Verbal Learning Test-II-Short Form, digit span, verbal fluency tests, and the Trailmaking Test, Part B (Trails B). Total sleep time (TST) and wake after sleep onset (WASO) tertiles were our primary predictors...
May 2, 2017: Sleep
https://www.readbyqxmd.com/read/28462742/suicide-and-assisted-dying-in-dementia-what-we-know-and-what-we-need-to-know-a-narrative-literature-review
#16
J Diehl-Schmid, R Jox, S Gauthier, S Belleville, E Racine, C Schüle, G Turecki, S Richard-Devantoy
BACKGROUND: Evidence-based data on prevalence and risk factors of suicidal intentions and behavior in dementia are as scarce as the data on assisted dying. The present literature review aimed on summarizing the current knowledge and provides a critical discussion of the results. METHODS: A systematic narrative literature review was performed using Medline, Cochrane Library, EMBASE, PSYNDEX, PSYCINFO, Sowiport, and Social Sciences Citation Index literature. RESULTS: Dementia as a whole does not appear to be a risk factor for suicide completion...
May 2, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28462390/bladder-antimuscarinics-and-cognitive-decline-in-elderly-patients
#17
Daniela C Moga, Erin L Abner, Qishan Wu, Gregory A Jicha
INTRODUCTION: The evidence on the impact of bladder antimuscarinics initiation on cognitive function in older adults is inconsistent. METHODS: A retrospective analysis of data from the National Alzheimer's Coordinating Center (NACC) on enrollees 65 years and older evaluated the association between antimuscarinic initiation and cognitive decline. We defined decline from baseline (yes/no) for cognitive assessments included in the NACC Uniform Data Set 2.0 battery...
January 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/28455846/tool-use-in-neurodegenerative-diseases-planning-or-technical-reasoning
#18
Josselin Baumard, Mathieu Lesourd, Chrystelle Remigereau, Christophe Jarry, Frédérique Etcharry-Bouyx, Valérie Chauviré, François Osiurak, Didier Le Gall
Recent works showed that tool use can be impaired in stroke patients because of either planning or technical reasoning deficits, but these two hypotheses have not yet been compared in the field of neurodegenerative diseases. The aim of this study was to address the relationships between real tool use, mechanical problem-solving, and planning skills in patients with Alzheimer's disease (AD, n = 32), semantic dementia (SD, n = 16), and corticobasal syndrome (CBS, n = 9). Patients were asked to select and use ten common tools, to solve three mechanical problems, and to complete the Tower of London test...
April 29, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28455505/apoe-%C3%A9-4-effects-on-longitudinal-decline-in-olfactory-and-non-olfactory-cognitive-abilities-in-middle-aged-and-old-adults
#19
Maria Josefsson, Maria Larsson, Steven Nordin, Rolf Adolfsson, Jonas Olofsson
Characterizing aging-related decline trajectories in mental abilities, and relationships of the ɛ4 allele of the Apolipoprotein gene, helps to identify individuals at high risk for dementia. However, longitudinal changes in olfactory and non-olfactory cognitive abilities have not been investigated in relation to the ɛ4 allele. In the present study, participants from a large population-based study (657 middle-aged and 556 old) were tested over 10 years on their performance on an odor identification task and three non-olfactory cognitive tasks; MMSE, episodic memory, and semantic memory...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28452649/neighborhood-socioeconomic-status-and-cognitive-trajectories-in-a-diverse-longitudinal-cohort
#20
Oanh L Meyer, Dan Mungas, Jesse King, Ladson Hinton, Sarah Farias, Bruce Reed, Charles DeCarli, Estella Geraghty, Laurel Beckett
OBJECTIVES: Although individual-level socioeconomic status is associated with poor outcomes, less is known regarding how the social context might affect cognitive outcomes. We examined the effect of neighborhood socioeconomic status (NSES) on baseline cognitive function and trajectories of decline. METHODS: The sample (N = 480) came from a longitudinal cohort recruited to study cognitive function. Mixed effects models examined the influence of NSES on baseline and rate of change in executive function, semantic memory, and episodic memory...
January 23, 2017: Clinical Gerontologist
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