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https://www.readbyqxmd.com/read/29235432/impact-of-informal-caregiving-on-cognitive-function-and-well-being-in-canada
#1
Sasha Mallya, Alexandra J Fiocco
BACKGROUND: With a rise in the aging population and a consequential rise in persons diagnosed with dementia comes an increase in the number of informal caregivers who are caring for a loved one. The objective of the proposed study was to assess the neurocognitive and psychological effects of caring for a person with dementia or a related neurodegenerative disease in a sample of Canadian informal caregivers. METHODS: Fifty-seven informal caregivers of a person with dementia or a related neurodegenerative disease (mean age = 66...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29228211/asymmetry-of-post-mortem-neuropathology-in-behavioural-variant-frontotemporal-dementia
#2
David J Irwin, Corey T McMillan, Sharon X Xie, Katya Rascovsky, Vivianna M Van Deerlin, H Branch Coslett, Roy Hamilton, Geoffrey Aguirre, Edward B Lee, Virginia M Y Lee, John Q Trojanowski, Murray Grossman
Antemortem behavioural and anatomic abnormalities have largely been associated with right hemisphere disease in behavioural-variant frontotemporal dementia, but post-mortem neuropathological examination of bilateral hemispheres remains to be defined. Here we measured the severity of post-mortem pathology in both grey and white matter using a validated digital image analysis method in four cortical regions sampled from each hemisphere in 26 patients with behavioural-variant frontotemporal dementia, including those with frontotemporal degeneration (i...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29213520/brazilian-transcultural-adaptation-of-an-instrument-on-communicative-strategies-of-caregivers-of-elderly-with-dementia
#3
Lais Lopes Delfino, Ricardo Shoiti Komatsu, Caroline Komatsu, Anita Liberalesso Neri, Meire Cachioni
Communication with patients with dementia may be a difficult task for caregivers. OBJECTIVE: The aim of this study was to produce a Brazilian transcultural adaptation of an instrument developed in Canada, called the Small Communication Strategies Scale, composed of 10 items constructed from 10 communicative strategies most recurrent in a literature survey. METHODS: Drawing on understanding of the construction of the Small Communication Strategies Scale (SCSS), a Brazilian Portuguese version of the instrument was devised through the following steps: translation, back-translation and semantic-cultural adaptation by a specialized linguist in English-Portuguese translations and application of the comprehension test for the version produced in a group of caregivers of elderly individuals with dementia...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213519/language-and-communication-non-pharmacological-interventions-in-patients-with-alzheimer-s-disease-a-systematic-review-communication-intervention-in-alzheimer
#4
Aline Nunes da Cruz Morello, Tatiane Machado Lima, Lenisa Brandão
Alzheimer's disease considerably compromises communication skills. Language changes become more prominent as the disease progresses. Deterioration of language and cognition reduces the ability of holding conversations, which has a negative impact on social interaction. OBJECTIVE: To conduct a systematic review of the literature for articles reporting interventions focused on the language and communication of people with Alzheimer's disease (AD) without use of medication. METHODS: We performed a search using the keywords Alzheimer's disease, language, communication, cognition, cognitive intervention, rehabilitation and therapy, and their corresponding Portuguese and Spanish terms, on the SciELO, LILACS, PubMed and PsychINFO databases...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213499/an-interdisciplinary-approach-aiding-the-diagnosis-of-primary-progressive-aphasia-a-case-report
#5
Nadia Shigaeff, Mayra Zanetti, Sibelle de Almeida Tierno, Ana Beatriz Galhardi Di Tommaso, Thais Cristina Marques, Fábio Gazelato de Mello Franco
Frontotemporal dementia (FTD) is one of the most common causes of early-onset dementia with primary progressive aphasia (PPA) being the second-most-frequent form of this degenerative disease. Despite the similarity with progressive dementia (especially in early stages of Alzheimer´s disease), three types of PPA can be differentiated: semantic, agrammatic and logopenic (subtype discussed in this study). To date, no medications have been shown to improve or stabilize cognitive deficits in patients with PPA. We report the case of a 62-year-old woman with difficulty naming objects and planning...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29209781/age-dependent-cognitive-dysfunction-in-untreated-hereditary-transthyretin-amyloidosis
#6
Ana Martins da Silva, Sara Cavaco, Joana Fernandes, Raquel Samões, Cristina Alves, Márcio Cardoso, Jeffery W Kelly, Cecília Monteiro, Teresa Coelho
Central nervous system (CNS) involvement in hereditary transthyretin (TTR) amyloidosis has been described in patients whose disease course was modified by liver transplant. However, cognitive dysfunction has yet to be investigated in those patients. Moreover, CNS involvement in untreated patients or asymptomatic mutation carriers remains to be studied. A series of 340 carriers of the TTRVal30Met mutation (180 symptomatic and 160 asymptomatic) underwent a neuropsychological assessment, which included the Dementia Rating Scale-2 (DRS-2), auditory verbal learning test, semantic fluency, phonemic fluency, and trail making test...
December 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29202669/the-relationship-between-smell-identification-and-neuropsychological-domains-results-from-a-sample-of-community-dwelling-adults-suspected-of-dementia
#7
William F Goette, Amy E Werry, Andrew L Schmitt
OBJECTIVE: This study aimed to test the theoretical relationships between smell identification and cognitive tasks based on existing neuroimaging and anatomical findings. METHOD: Utilizing data collected from a memory assessment clinic, theory-derived mediation and moderation models were tested. The sample used in this study consisted of 103 (39 male, 64 female) individuals referred for memory assessments. The sample's mean education was 12.4 years (SD = 3.2), and the mean age of the sample was 77...
December 4, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29201014/impaired-interoceptive-accuracy-in-semantic-variant-primary-progressive-aphasia
#8
Charles R Marshall, Chris J D Hardy, Lucy L Russell, Camilla N Clark, Katrina M Dick, Emilie V Brotherhood, Rebecca L Bond, Catherine J Mummery, Jonathan M Schott, Jonathan D Rohrer, James M Kilner, Jason D Warren
Background: Interoception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects. Interoceptive impairment may contribute to the profound socioemotional symptoms that characterize frontotemporal dementia (FTD) syndromes, but remains poorly defined. Methods: Patients representing all major FTD syndromes and healthy age-matched controls performed a heartbeat counting task as a measure of interoceptive accuracy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29186630/music-models-aberrant-rule-decoding-and-reward-valuation-in-dementia
#9
Camilla N Clark, Hannah L Golden, Oliver McCallion, Jennifer M Nicholas, Miriam H Cohen, Catherine F Slattery, Ross W Paterson, Phillip D Fletcher, Catherine J Mummery, Jonathan D Rohrer, Sebastian J Crutch, Jason D Warren
Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterised. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia syndromes and Alzheimer's disease relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved ('finished') or unresolved ('unfinished'); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation)...
November 24, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29186313/the-latent-structure-and-test-retest-stability-of-connected-language-measures-in-the-wisconsin-registry-for-alzheimer-s-prevention-wrap
#10
Kimberly D Mueller, Rebecca L Koscik, Lindsay R Clark, Bruce P Hermann, Sterling C Johnson, Lyn S Turkstra
Introduction: While it is well known that discourse-related language functions are impaired in the dementia phase of Alzheimer's Disease (AD), the presymptomatic temporal course of discourse dysfunction are not known earlier in the course of AD. To conduct discourse-related studies in this phase of AD, validated psychometric instruments are needed. This study investigates the latent structure, validity, and test-retest stability of discourse measures in a late-middle-aged normative group who are relatively free from sporadic AD risk factors...
November 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29182360/relationship-between-smell-identification-testing-and-the-neuropsychological-assessment-of-dementia-in-community-dwelling-adults
#11
William Goette, Andrew Schmitt, Avery Clark
The objective of this research was to investigate the relationship of the University of Pennsylvania Smell Identification Test (UPSIT) with neuropsychological tests and identify the utility of the UPSIT in detecting cognitive impairment. This research was an archival study of neuropsychological test results obtained from 70 clients (30 male/40 female) of a community-based memory clinic. The sample had an average age of 69.7 (SD = 9.7) and education of 14.6 (SD = 2.8) years. Hypotheses were tested using correlations, receiver operating characteristic (ROC) curves, and logistic regression...
November 28, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29166955/brain-arterial-diameters-and-cognitive-performance-the-northern-manhattan-study
#12
Jose Gutierrez, Erin Kulick, Yeseon Park Moon, Chuanhui Dong, Ken Cheung, Bagci Ahmet, Yaakov Stern, Noam Alperin, Tatjana Rundek, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind
OBJECTIVES: To test the hypothesis that brain arterial diameters are associated with cognitive performance, particularly in arteries supplying domain-specific territories. METHODS: Stroke-free participants in the Northern Manhattan Study were invited to have a brain MRI from 2003-2008. The luminal diameters of 13 intracranial arterial segments were obtained using time-of-flight magnetic resonance angiogram (MRA), and then averaged and normalized into a global score and region-specific arterial diameters...
November 23, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29159036/eeg-oscillations-during-word-processing-predict-mci-conversion-to-alzheimer-s-disease
#13
Ali Mazaheri, Katrien Segaert, John Olichney, Jin-Chen Yang, Yu-Qiong Niu, Kim Shapiro, Howard Bowman
Only a subset of mild cognitive impairment (MCI) patients progress to develop a form of dementia. A prominent feature of Alzheimer's disease (AD) is a progressive decline in language. We investigated if subtle anomalies in EEG activity of MCI patients during a word comprehension task could provide insight into the likelihood of conversion to AD. We studied 25 amnestic MCI patients, a subset of whom developed AD within 3-years, and 11 elderly controls. In the task, auditory category descriptions (e.g., 'a type of wood') were followed by a single visual target word either semantically congruent (i...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29107846/relevance-of-raised-cerebrospinal-fluid-monocyte-levels-in-patients-with-frontotemporal-dementia
#14
Matthias Pawlowski, Gero Lueg, Catharina C Gross, Andreas Johnen, Julia Krämer, Matthias Weckesser, Heinz Wiendl, Sven G Meuth, Thomas Duning
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. In this study, we performed comprehensive immune cell profiling in the cerebrospinal fluid (CSF) and peripheral blood of patients with FTD. Thirty-two patients with behavioral variant frontotemporal dementia and 25 patients with primary progressive aphasia were included and compared to 14 healthy elderly controls. All patients underwent neuropsychological examination, magnetic resonance imaging, voxel-based diffusion tensor imaging, and peripheral blood and CSF immune cell profiling by multiparameter flow cytometry...
October 13, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29105852/frontotemporal-lobar-degeneration-due-to-p301l-tau-mutation-showing-apathy-and-severe-frontal-atrophy-but-lacking-other-behavioral-changes-a-case-report-and-literature-review
#15
Tomoko Miki, Osamu Yokota, Shintaro Takenoshita, Yoko Mori, Kiyohiro Yamazaki, Yuki Ozaki, Shu-Ichi Ueno, Takashi Haraguchi, Hideki Ishizu, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
The clinical features in cases that have mutations in the microtubule-associated protein tau gene but lack prominent behavioral changes remain unclear. Here, we describe detailed clinical and pathological features of a case carrying the P301L tau mutation that showed only apathy until the middle stage of the course. The mother of this case was suspected to have mild cognitive decline at age 46. However, before she was fully examined, she had a subarachnoid hemorrhage at age 49 and died at age 53. An autopsy was not done...
November 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29098943/vitamin-intake-is-associated-with-improved-visuospatial-and-verbal-semantic-memory-in-middle-aged-individuals
#16
Miles Flitton, Ian A Macdonald, Helen M Knight
OBJECTIVES: Factors maintaining cognitive health are still largely unknown. In particular, the cognitive benefits associated with vitamin intake and vitamin supplementation are disputed. We investigated self-reported vitamin intake and serum vitamin levels with performance in cognitive factors sensitive to dementia progression in two large middle-aged general population cohorts. METHODS: Survey data were used to assess regular vitamin intake in 4400 NCDS 1958 and 1177 TwinsUK cohort members, and serum homocysteine and B vitamin levels were measured in 675 individuals from the TwinsUK study...
November 3, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29065116/serum-igf-1-is-associated-with-cognitive-functions-in-early-drug-na%C3%A3-ve-parkinson-s-disease
#17
Marina Picillo, Rosario Pivonello, Gabriella Santangelo, Claudia Pivonello, Riccardo Savastano, Renata Auriemma, Marianna Amboni, Sara Scannapieco, Angela Pierro, Annamaria Colao, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease. METHODS: Serum IGF-1 levels were determined in 405 early, drug-naïve PD patients and 191 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI)...
2017: PloS One
https://www.readbyqxmd.com/read/29054264/using-artificial-neural-networks-to-select-the-parameters-for-the-prognostic-of-mild-cognitive-impairment-and-dementia-in-elderly-individuals
#18
REVIEW
A J C C Lins, M T C Muniz, A N M Garcia, A V Gomes, R M Cabral, C J A Bastos-Filho
BACKGROUND AND OBJECTIVES: A huge number of solutions based on computational systems have been recently developed for the classification of cognitive abnormalities in older people, so that individuals at high risk of developing neurodegenerative diseases, such as Cognitive Impairment and Alzheimer?s disease, can be identified before the manifestation of the diseases. Several factors are related to these pathologies, making the diagnostic process a hard problem to solve. This paper proposes a computational model based on the artificial neural network to classify data patterns of older adults...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#19
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28993004/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-for-a-specific-neuropsychological-pattern
#20
REVIEW
M Planton, N Raposo, J-F Albucher, J Pariente
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years...
November 2017: Revue Neurologique
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