Youzhuang Zhu, Qun Li, Guilin Liu, Fang Sheng, Xiaotian Zhang, Lili Jiang, Shaona Li, Jianshuai He, Zhijin Zou, Baobo Zhang, Changyao Wang, Xin Jiang, Yang Zhao
INTRODUCTION: Rebound pain, transient and acute postoperative pain after the disappearance of regional block anesthesia, has been a concern in recent years. Insufficient preemptive analgesia and hyperalgesia induced by regional block are the main mechanisms. At present, the evidence for the treatment of rebound pain is limited. The esketamine, as an antagonist of the N-methyl-D-aspartate receptor, has been proven to prevent hyperalgesia. Therefore, this trial aims to evaluate the impact of esketamine on postoperative rebound pain in patients undergoing total knee arthroplasty...
2023: Frontiers in Neurology