keyword
https://read.qxmd.com/read/38301863/repetitive-head-trauma-and-apoe4-induce-chronic-cerebrovascular-alterations-that-impair-tau-elimination-from-the-brain
#21
JOURNAL ARTICLE
Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Milica Koprivica, Arianna Cembran, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeier
Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports have been associated with the accumulation of extracellular tau in the brain, which may contribute to the pathogenesis of neurodegenerative tauopathies. The expression of the apolipoprotein E4 (apoE4) isoform has been associated with higher levels of tau in the brain, and worse clinical outcomes after r-mTBI, though the influence of apoE genotype on extracellular tau dynamics in the brain is poorly understood. We recently demonstrated that extracellular tau can be eliminated across blood-brain barrier (BBB), which is progressively impaired following r-mTBI...
April 2024: Experimental Neurology
https://read.qxmd.com/read/38263241/cerebral-autoregulation-in-traumatic-brain-injury-ultra-low-frequency-pressure-reactivity-index-and-intracranial-pressure-across-age-groups
#22
JOURNAL ARTICLE
Paolo Gritti, Marco Bonfanti, Rosalia Zangari, Ezio Bonanomi, Alessia Farina, Giulio Pezzetti, Isabella Pelliccioli, Luca Longhi, Maria Di Matteo, Andrea Viscone, Gabriele Lando, Gaia Cavalleri, Simonetta Gerevini, Francesco Biroli, Ferdinando Luca Lorini
BACKGROUND: The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this index has been shown to be a predictor of outcome in adult and pediatric patients with traumatic brain injury (TBI), a comprehensive evaluation of low sampling rate data collection (0.0033 Hz averaged over 5 min) on cerebrovascular reactivity has never been performed. OBJECTIVE: To evaluate the performance and predictive power of the UL-PRx for 12-month outcome measures, alongside all International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) models and in different age groups...
January 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38257592/non-invasive-estimation-of-intracranial-pressure-derived-cerebrovascular-reactivity-using-near-infrared-spectroscopy-sensor-technology-in-acute-neural-injury-a-time-series-analysis
#23
JOURNAL ARTICLE
Alwyn Gomez, Logan Froese, Tobias J G Bergmann, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Abrar Islam, Kevin Y Stein, Izabella Marquez, Younis Ibrahim, Frederick A Zeiler
The contemporary monitoring of cerebrovascular reactivity (CVR) relies on invasive intracranial pressure (ICP) monitoring which limits its application. Interest is shifting towards near-infrared spectroscopic regional cerebral oxygen saturation (rSO2 )-based indices of CVR which are less invasive and have improved spatial resolution. This study aims to examine and model the relationship between ICP and rSO2 -based indices of CVR. Through a retrospective cohort study of prospectively collected physiologic data in moderate to severe traumatic brain injury (TBI) patients, linear mixed effects modeling techniques, augmented with time-series analysis, were utilized to evaluate the ability of rSO2 -based indices of CVR to model ICP-based indices...
January 13, 2024: Sensors
https://read.qxmd.com/read/38253324/early-pharmacologic-therapy-in-patients-with-blunt-cerebrovascular-injury-and-tbi-is-it-safe-and-effective-an-east-multicenter-study
#24
JOURNAL ARTICLE
William Kelley, Khaled Zreik, Anna Gergen, Jamie Williams, Lewis E Jacobson, Jeffry Nahmias, Anthony Tatar, Jason Murry, Areg Grigorian, Adrian Ong, Deborah M Stein, Thomas M Scalea, Margaret H Lauerman
BACKGROUND: Blunt cerebrovascular injury (BCVI) with concurrent traumatic brain injury (TBI) presents increased risk of both ischemic stroke and bleeding. This study investigated the safety and survival benefit of BCVI treatment (antithrombotic and/or anticoagulant therapy) in this population. We hypothesized that treatment would be associated with fewer and later strokes in patients with BCVI and TBI without increasing bleeding complications. METHODS: Patients with head AIS >0 were selected from a database of BCVI patients previously obtained for an observational trial...
January 22, 2024: American Surgeon
https://read.qxmd.com/read/38245634/the-value-of-computed-tomography-angiography-in-predicting-the-surgical-effect-and-prognosis-of-severe-traumatic-brain-injury
#25
MULTICENTER STUDY
Junhui Chen, Wei Zhao, Xiaoming Zhu, Likun Yang, Chengjun Geng, Xu Zhang, Yuhai Wang
It is difficult to predict the surgical effect and outcome of severe traumatic brain injury (TBI) before surgery. This study aims to approve an evaluation method of computed tomography angiography (CTA) to predict the effect of surgery and outcome in severe TBI. Between January 2010 and January 2020, we retrospectively reviewed 358 severe TBI patients who underwent CTA at admission and reexamination. CTA data were evaluated for the presence of cerebrovascular changes, including cerebrovascular shift (CS), cerebral vasospasm (CVS), large artery occlusion (LAO), and deep venous system occlusion (DVSO)...
January 20, 2024: Scientific Reports
https://read.qxmd.com/read/38229824/rehabilitation-of-traumatic-acute-subdural-hematoma-and-subarachnoid-hemorrhage-a-case-report
#26
Amisha P Zade, Shruti S Bhoge, Nikita H Seth, Pratik Phansopkar
A head injury or cerebrovascular illness may be the cause of acute intracranial hemorrhage. Making a precise diagnosis is challenging since diagnostic imaging might be challenging in both situations. In this case report, an aneurysmal rupture related head injury resulted in an acute subdural hematoma (SHD) after the patient lost consciousness. A 54-year-old male was found in a state of unconsciousness on the ground and was brought to the nearest hospital. Computed tomography (CT) scan showed an oblique fracture involving the bilateral frontal and right parietal bones along with underlying SDH, subarachnoid hemorrhage (SAH), and hemorrhagic contusion along with midline shift...
December 2023: Curēus
https://read.qxmd.com/read/38218407/deferoxamine-reduces-endothelial-ferroptosis-and-protects-cerebrovascular-function-after-experimental-traumatic-brain-injury
#27
JOURNAL ARTICLE
Yidan Liang, Yanglingxi Wang, Chao Sun, Yi Xiang, Yongbing Deng
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly contributes to poor patient outcomes. Recent studies revealed the involvement of iron metabolism in neuronal survival, yet its effect on vasculature remains unclear. This study aims to explore the impact of endothelial ferroptosis on cerebrovascular function in TBI. A Controlled Cortical Impact (CCI) model was established in mice, resulting in a significant increase in iron-related proteins such as TfR1, FPN1, and FTH, as well as oxidative stress biomarker 4HNE...
January 11, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38203813/effects-of-low-level-blast-on-neurovascular-health-and-cerebral-blood-flow-current-findings-and-future-opportunities-in-neuroimaging
#28
REVIEW
Madison O Kilgore, W Brad Hubbard
Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood flow (CBF). The development of cognitive issues and behavioral abnormalities after LLB, or subconcussive blast exposure, is insidious due to the lack of acute symptoms. One major hallmark of LLB exposure is the initiation of neurovascular damage followed by the development of neurovascular dysfunction. Preclinical studies of LLB exposure demonstrate impairment to cerebral vasculature and the blood-brain barrier (BBB) at both early and long-term stages following LLB...
January 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38178989/intracranial-dynamics-biomarkers-at-traumatic-cerebral-vasospasm
#29
JOURNAL ARTICLE
Alexey O Trofimov, Svetlana Y Trofimova, Darya I Agarkova, Kseniia A Trofimova, Oxana Semyachkina-Glushkovskaya, Dmitriy Atochin, Olga A Bragina, Edwin M Nemoto, Denis E Bragin
INTRODUCTION: Patients who suffer severe traumatic brain injury (sTBI) and cerebral vasospasm (CVS) frequently have posttraumatic cerebral ischemia (PCI). THE RESEARCH QUESTION: was to study changes in cerebral microcirculatory bed parameters in sTBI patients with CVS and with or without PCI. MATERIAL AND METHODS: A total of 136 severe TBI patients were recruited in the study. All patients underwent perfusion computed tomography, intracranial pressure monitoring, and transcranial Doppler...
2024: Brain Spine
https://read.qxmd.com/read/38167367/functional-improvements-associated-with-cranioplasty-after-stroke-and-traumatic-brain-injury-a-cohort-study
#30
JOURNAL ARTICLE
F Coelho, G S Noleto, D J F Solla, P N Martins, A F Andrade, M J Teixeira, W S Paiva, R Anghinah
OBJECTIVE: Decompressive craniectomy is part of the acute management of several neurosurgical illnesses, and is commonly followed by cranioplasty. Data are still scarce on the functional and cognitive outcomes following cranioplasty. We aim to evaluate these outcomes in patients who underwent cranioplasty following traumatic brain injury (TBI) or stroke. METHODS: In this prospective cohort, we assessed 1-month and 6-month neuropsychological and functional outcomes in TBI and stroke patients who underwent cranioplasty at a Brazilian tertiary center...
December 2023: Brain Impairment: a Multidisciplinary Journal of the Australian Society for the Study of Brain Impairment
https://read.qxmd.com/read/38167027/impact-of-nqo1-dysregulation-in-cns-disorders
#31
REVIEW
Li Yuhan, Maryam Khaleghi Ghadiri, Ali Gorji
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous system (CNS). Impairment of the NQO1 activity in the CNS can result in abnormal neurotransmitter release and clearance, increased oxidative stress, and aggravated cellular injury/death. Furthermore, it can cause disturbances in neural circuit function and synaptic neurotransmission...
January 2, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38157533/evaluating-mortality-and-6-month-functional-outcomes-of-patients-with-dural-venous-sinus-thrombosis-in-traumatic-brain-injury
#32
JOURNAL ARTICLE
Mark D Johnson, Giancarlo J Ventre, Joel Kaye, Hemchandra B Patel, Asad Naveed, Charles J Prestigiacomo, Laura B Ngwenya
OBJECTIVE: Patients with dural venous sinus thrombosis (DVST) in select populations following traumatic brain injury (TBI), including those with blunt mechanism or depressed skull fractures, have been shown to have an increased risk of mortality. The purpose of this study was to assess these findings in a mixed population of head trauma patients. METHODS: The authors performed a case-control study using propensity score matching by reviewing 17 years (2004-2021) of data from their institutional trauma registry...
December 29, 2023: Journal of Neurosurgery
https://read.qxmd.com/read/38156075/cerebrovascular-pressure-reactivity-measures-index-comparison-and-clinical-outcome-in-patients-with-traumatic-brain-injury-treated-according-to-an-intracranial-pressure-focused-management-rejection-of-the-null-hypothesis
#33
JOURNAL ARTICLE
Axel Risinger Liljegren, Camilla Brorsson, Marcus Karlsson, Lars-Owe D Koskinen, Nina Sundström
The aim was to investigate whether the pressure reactivity indices PRx, long-PRx (L-PRx), and pressure reactivity (PR) are interchangeable as measures of vascular reactivity, and whether they correlate with clinical outcome when an intracranial pressure (ICP)-targeted treatment regimen is applied in patients with traumatic brain injury (TBI). Patients with TBI ( n  = 29) that arrived at the hospital within 24 h of injury were included. PRx and L-PRx were derived from Pearson correlations between mean arterial pressure (MAP) and ICP over a short- and long-time interval...
2023: Neurotrauma reports
https://read.qxmd.com/read/38128696/medical-management-of-traumatic-vertebral-artery-injury-is-safe-regardless-of-the-severity-of-injury
#34
JOURNAL ARTICLE
Hans K Boggs, Roger T Tomihama, Zachary Tran, Kaushik Mukherjee, David Turay, Emelyn Magtanong, Andrew Pop, Sharon C Kiang
OBJECTIVES: Management of traumatic vertebral artery injury (VAI) remains under debate. Current consensus reserves surgical or endovascular management for high-grade injury in order to prevent stroke. We sought to evaluate the factors that influence posterior fossa stroke outcomes following traumatic VAI. METHODS: A search of the prospectively maintained PROOVIT Trauma Registry of patients older than 18 years of age with a diagnosis of VAI was performed at a Level 1 Trauma Center from 2013-2019...
December 19, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/38125961/mechanical-thrombectomy-and-parent-artery-occlusion-for-acute-basilar-artery-occlusion-due-to-vertebral-fracture-and-artery-dissection-a-case-report
#35
Shin Hirota, Satoru Takahashi, Masataka Yoshimura, Sakyo Hirai, Takamaro Takei, Asumi Orihara, Hirotaka Sagawa, Hikaru Wakabayashi, Shoko Fuji, Shinji Yamamoto, Kazutaka Sumita
OBJECTIVE: Basilar artery occlusion (BAO) secondary to traumatic vertebral artery (VA) dissection caused by vertebral fracture is a rare cause of acute ischemic stroke, and optimal management, such as antithrombotic agents, surgical fixation, and parent artery occlusion (PAO), has been controversial. We report a case in which mechanical thrombectomy and PAO were performed for a BAO due to right VA dissection caused by a transverse foramen fracture of the axis vertebra. CASE PRESENTATION: A patient in her 80s suffered from a backward fall, and a neck CT revealed a fracture and dislocation of the right lateral mass of the axis and a compressed transverse foramen...
2023: Journal of neuroendovascular therapy
https://read.qxmd.com/read/38110079/analysis-of-extracranial-cerebrovascular-injuries-clinical-predictors-of-management-and-outcomes
#36
JOURNAL ARTICLE
Hans K Boggs, Sharon C Kiang, Zachary Tran, Kaushik Mukherjee, Roger T Tomihama
OBJECTIVE: Optimal management of traumatic extracranial cerebrovascular injuries (ECVI) remains undefined. We sought to evaluate the factors that influence management, and neurologic outcomes (stroke and brain death) following traumatic ECVI. METHOD: A retrospective review of a single level 1 trauma center's prospectively maintained data registry of patients older than 18 years of age with a diagnosis of ECVI was performed from 2013-2019. Injuries limited to the external carotid artery were excluded...
December 16, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/38095819/time-spent-above-optimal-cerebral-perfusion-pressure-is-not-associated-with-failure-to-improve-in-outcome-in-traumatic-brain-injury
#37
JOURNAL ARTICLE
Kevin Y Stein, Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Younis Ibrahim, Abrar Islam, Izabella Marquez, Fiorella Amenta, Tobias Bergmann, Frederick A Zeiler
BACKGROUND: Optimal cerebral perfusion pressure (CPPopt) has emerged as a promising personalized medicine approach to the management of moderate-to-severe traumatic brain injury (TBI). Though literature demonstrating its association with poor outcomes exists, there is yet to be work done on its association with outcome transition due to a lack of serial outcome data analysis. In this study we investigate the association between various metrics of CPPopt and failure to improve in outcome over time...
December 14, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38069842/microglial-histone-deacetylase-2-is-dispensable-for-functional-and-histological-outcomes-in-a-mouse-model-of-traumatic-brain-injury
#38
JOURNAL ARTICLE
Yue Zhang, Yongfang Zhao, Yana Wang, Jiaying Li, Yichen Huang, Fan Lyu, Yangfan Wang, Pengju Wei, Yiwen Yuan, Yi Fu, Yanqin Gao
The Class-I histone deacetylases (HDACs) mediate microglial inflammation and neurological dysfunction after traumatic brain injury (TBI). However, whether the individual Class-I HDACs play an indispensable role in TBI pathogenesis remains elusive. HDAC2 has been shown to upregulate pro-inflammatory genes in myeloid cells under brain injuries such as intracerebral hemorrhage, thereby worsening outcomes. Thus, we hypothesized that HDAC2 drives microglia toward a pro-inflammatory neurotoxic phenotype in a murine model of controlled cortical impact (CCI)...
December 9, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38043751/post-traumatic-headache-pathophysiology-in-paediatric-concussion-a-systematic-review
#39
REVIEW
Feiven Fan, Vicki Anderson, Thilanka Morawakage, Noor Khan, Jesse S Shapiro, Vera Ignjatovic, Michael Takagi
Post-traumatic headache (PTH) represents the most common acute and persistent symptom following concussion in children, yet the underlying pathophysiology remains unclear. This systematic review sought to: (i) rigorously examine the current evidence of PTH pathophysiology in paediatric concussion (0-18 years), (ii) assess the quality of evidence, and (iii) provide directions for future research in accordance with PRISMA guidelines. Eligible studies (n = 19) totalling 1214 concussion participants investigated cerebrovascular function (n = 6), white matter integrity (n = 3), functional connectivity (n = 3), electrophysiology (n = 1), neurometabolics (n = 2), biological fluid markers (n = 4), vestibular and oculomotor function (n = 4); two studies used a multi-modal approach...
January 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38030876/dynamics-of-intracranial-pressure-and-cerebrovascular-reactivity-during-intrahospital-transportation-of-traumatic-brain-injury-patients-in-coma
#40
JOURNAL ARTICLE
Alexey O Trofimov, Darya I Agarkova, Kseniia A Trofimova, Dmitriy N Atochin, Edwin M Nemoto, Denis E Bragin
BACKGROUND: Intrahospital transportation (IHT) of patients with traumatic brain injury (TBI) is common and may have adverse consequences, incurring inherent risks. The data on the frequency and severity of clinical complications linked with IHT are contradictory, and there is no agreement on whether it is safe or potentially challenging for neurocritical care unit patients. Continuous intracranial pressure (ICP) monitoring is essential in neurointensive care. The role of ICP monitoring and management of cerebral autoregulation impairments in IHT of patients with severe TBI is underinvestigated...
November 29, 2023: Neurocritical Care
keyword
keyword
63503
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.