keyword
https://read.qxmd.com/read/38492727/stroke-prevention-in-blunt-cerebrovascular-injury-role-of-aspirin-81-mg
#1
JOURNAL ARTICLE
Sina Asaadi, Christopher B Khoury, Julia Han, Martin G Rosenthal, Allen G Murga, Justin Dye, Kaushik Mukherjee, Miguel Lopez-Gonzalez, Ian Kershisnik, Marie L Crandall, Maryam B Tabrizi
BACKGROUND: The stroke rate in blunt cerebrovascular injury (BCVI) varies from 25% without treatment to less than 8% with antithrombotic therapy (ATT). There is no consensus on the optimal management to prevent stroke BCVI. We investigated the efficacy and safety of oral Aspirin (ASA) 81 mg to prevent BCVI-related stroke compared to historically reported stroke rates with ASA 325 mg and heparin. METHOD: A single-center retrospective study included adult trauma patients who received oral ASA 81 mg for BCVI management between 2013 and 2022...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38491407/bilateral-vertebral-artery-injury-leads-to-brain-death-following-traumatic-brain-injury-a-case-report
#2
JOURNAL ARTICLE
Vera Irawany, Vizzi A F Nasution, Noorcahya Amalia
BACKGROUND: Vertebral artery injury is a rare condition in trauma settings. In the advanced stages, it causes death. CASE: A 31-year-old Sundanese woman with cerebral edema, C2-C3 anterolisthesis, and Le Fort III fracture after a motorcycle accident was admitted to the emergency room. On the fifth day, she underwent arch bar maxillomandibular application and debridement in general anesthesia with a hyperextended neck position. Unfortunately, her rigid neck collar was removed in the high care unit before surgery...
March 16, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38486211/prognostic-value-of-near-infrared-spectroscopy-regional-oxygen-saturation-and-cerebrovascular-reactivity-index-in-acute-traumatic-neural-injury-a-canadian-high-resolution-traumatic-brain-injury-cahr-tbi-cohort-study
#3
JOURNAL ARTICLE
Alwyn Gomez, Logan Froese, Donald Griesdale, Eric P Thelin, Rahul Raj, Levi van Iperenburg, Jeanette Tas, Marcel Aries, Kevin Y Stein, Clare Gallagher, Francis Bernard, Andreas H Kramer, Frederick A Zeiler
BACKGROUND: Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2 ) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high spatial resolution. However, the prognostic utility of these parameters has not yet been determined. This study aimed to identify threshold values of rSO2 and rSO2 -based CVR at which outcomes worsened following traumatic brain injury (TBI). METHODS: A retrospective multi-institutional cohort study was performed...
March 14, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38468559/transcranial-doppler-ultrasound-and-concussion-supplemental-symptoms-with-physiology-a-systematic-review
#4
JOURNAL ARTICLE
Matthew Neill, Joel Burma, Lauren N Miutz, Courtney Kennedy, Linden Penner, Kailey Newel, Jonathan Smirl
Sport-related concussion (SRC) can impair the cerebrovasculature both acutely and chronically. Transcranial Doppler (TCD) ultrasound assessment has the potential to illuminate the mechanisms of impairment and provide an objective evaluation of SRC. The current systematic review investigated studies employing TCD ultrasound assessment of intracranial arteries across three broad categories of cerebrovascular regulation: neurovascular coupling (NVC), cerebrovascular reactivity (CVR), and dynamic cerebral autoregulation (dCA)...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38468544/neurovascular-coupling-in-acutely-concussed-adolescent-patients
#5
JOURNAL ARTICLE
Patricia Roby, Anne E Mozel, Matthew F Grady, Tina Master, Kristy B Arbogast
Neurovascular coupling (NVC) uniquely describes cerebrovascular response to neural activation and has demonstrated impairments following concussion in adult patients. It is currently unclear how adolescent patients experience impaired neurovascular coupling acutely following concussion during this dynamic phase of physiological development. The purpose of this study was to investigate NVC in acutely concussed adolescent patients relative to controls. We recruited patients presenting to a sports medicine practice within 28 days of a concussion or a musculoskeletal injury (controls)...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38468047/computational-fractal-based-analysis-of-mr-susceptibility-weighted-imaging-swi-in-neuro-oncology-and-neurotraumatology
#6
JOURNAL ARTICLE
Antonio Di Ieva
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique able to depict the magnetic susceptibility produced by different substances, such as deoxyhemoglobin, calcium, and iron. The main application of SWI in clinical neuroimaging is detecting microbleedings and venous vasculature. Quantitative analyses of SWI have been developed over the last few years, aimed to offer new parameters, which could be used as neuroimaging biomarkers. Each technique has shown pros and cons, but no gold standard exists yet...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38467046/infantile-traumatic-pericallosal-aneurysm-illustrative-case
#7
JOURNAL ARTICLE
Zachary S Hubbard, Conor M Cunningham, Brian F Saway, Matthew J Triano, Aaron T Miller, Guilherme Porto, Libby Kosnik Infinger, Alejandro M Spiotta
BACKGROUND: Traumatic aneurysms are a rare sequela of nonaccidental head trauma in infants. The rate of nonaccidental trauma (NAT) in the pediatric population is increasing; therefore, traumatic aneurysms are an important consideration in the evaluation of pediatric patients with abusive head trauma. OBSERVATIONS: A 24-day-old infant with no significant past medical or birth history presented with twitching and poor oral intake for 1 day. The patient was found to have bilateral subdural hematomas, multifocal contusions, and traumatic subarachnoid hemorrhage...
March 11, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38445389/lack-of-association-of-informant-reported-traumatic-brain-injury-and-chronic-traumatic-encephalopathy
#8
JOURNAL ARTICLE
Julia Elizabeth Culhane, Colleen Jackson, Yorghos Tripodis, Christopher Nowinski, Kristen Dams-O'Connor, Erica Pettway, Madeline Uretsky, Bobak Abdolmohammadi, Evan Nair, Brett Martin, Joseph Palmisano, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Lee E Goldstein, Neil W Kowall, Robert C Cantu, Robert A Stern, Bertrand Huber, John Crary, Jesse Mez, Thor D Stein, Ann C McKee, Michael L Alosco
Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear if a history of traumatic brain injury (TBI) is sufficient to precipitate CTE neuropathology. We examined the association between TBI and CTE neuropathology in 580 deceased individuals exposed to RHIs from football. TBI was assessed using a modified version of the Ohio State University TBI Identification Method Short Form administered to informants. 22 donors had no TBI, 213 had at least one TBI without LOC, 345 had TBI with LOC, and, of those with a history of TBI with LOC, 36 had at least one msTBI (LOC >30 minutes)...
March 6, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38443709/dose-dependent-tranexamic-acid-blunting-of-penumbral-leukocyte-mobilization-and-blood-brain-barrier-permeability-following-traumatic-brain-injury-an-in-vivo-murine-study
#9
JOURNAL ARTICLE
Matthew C Culkin, Priyanka Bele, Anastasia P Georges, Patricia Santos, Grace Niziolek, Lewis J Kaplan, Douglas H Smith, Jose L Pascual
BACKGROUND: Early posttraumatic brain injury (TBI) tranexamic acid (TXA) may reduce blood-brain barrier (BBB) permeability, but it is unclear if this effect is fixed regardless of dose. We hypothesized that post-TBI TXA demonstrates a dose-dependent reduction of in vivo penumbral leukocyte mobilization, BBB microvascular permeability, and enhancement of neuroclinical recovery. METHODS: CD1 male mice (n = 40) were randomly assigned to TBI by controlled cortical impact (injury [I]) or sham TBI (S), followed by intravenous bolus of either saline (placebo [P]) or TXA (15, 30, or 60 mg/kg)...
March 5, 2024: Neurocritical Care
https://read.qxmd.com/read/38425208/visualization-of-the-intracranial-pressure-and-time-burden-in-childhood-brain-trauma-what-we-have-learnt-one-decade-on-with-kidsbrainit
#10
JOURNAL ARTICLE
Bavo Kempen, Bart Depreitere, Ian Piper, Juan Sahuquillo, Stefan Mircea Iencean, Hari Krishnan Kanthimathinathan, Julian Zipfel, Arta Barzdina, Stefano Pezzato, Patricia A Jones, Tsz-Yan Milly M Lo
To validate the intracranial pressure (ICP) dose-response visualization plot for the first time in a novel prospectively collected pediatric traumatic brain injury (pTBI) data set from the multi-center multi-national KidsBrainIT consortium. Prospectively collected minute-by-minute ICP and mean arterial blood pressure time series of 104 pTBI patients were categorized in ICP intensity-duration episodes. These episodes were correlated with the 6-month Glasgow Outcome Score (GOS) and displayed in a color-coded ICP dose-response plot...
February 29, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38388365/non-pharmacological-interventions-for-traumatic-brain-injury
#11
REVIEW
Charles K Davis, Vijay Arruri, Pallavi Joshi, Raghu Vemuganti
Heterogeneity and variability of symptoms due to the type, site, age, sex, and severity of injury make each case of traumatic brain injury (TBI) unique. Considering this, a universal treatment strategy may not be fruitful in managing outcomes after TBI. Most of the pharmacological therapies for TBI aim at modifying a particular pathway or molecular process in the sequelae of secondary injury rather than a holistic approach. On the other hand, non-pharmacological interventions such as hypothermia, hyperbaric oxygen, preconditioning with dietary adaptations, exercise, environmental enrichment, deep brain stimulation, decompressive craniectomy, probiotic use, gene therapy, music therapy, and stem cell therapy can promote healing by modulating multiple neuroprotective mechanisms...
February 22, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38373483/investigating-neuropathological-changes-and-underlying-neurobiological-mechanisms-in-the-early-stages-of-primary-blast-induced-traumatic-brain-injury-insights-from-a-rat-model
#12
JOURNAL ARTICLE
Xiyan Zhu, Xiang Chu, Hao Wang, Zhikang Liao, Hongyi Xiang, Wenbing Zhao, Li Yang, Pengfei Wu, Xing Liu, Diyou Chen, Jingru Xie, Wei Dai, Lei Li, Jianmin Wang, Hui Zhao
The utilization of explosives and chemicals has resulted in a rise in blast-induced traumatic brain injury (bTBI) in recent times. However, there is a dearth of diagnostic biomarkers and therapeutic targets for bTBI due to a limited understanding of biological mechanisms, particularly in the early stages. The objective of this study was to examine the early neuropathological characteristics and underlying biological mechanisms of primary bTBI. A total of 83 Sprague Dawley rats were employed, with their heads subjected to a blast shockwave of peak overpressure ranging from 172 to 421 kPa in the GI, GII, and GIII groups within a closed shock tube, while the body was shielded...
February 17, 2024: Experimental Neurology
https://read.qxmd.com/read/38367075/nervous-system-response-to-neurotrauma-a-narrative-review-of-cerebrovascular-and-cellular-changes-after-neurotrauma
#13
REVIEW
Hossam Tharwat Ali, Idris Sula, Abrar AbuHamdia, Sewar A Elejla, Ahmed Elrefaey, Hiba Hamdar, Mohamed Elfil
Neurotrauma is a significant cause of morbidity and mortality worldwide. For instance, traumatic brain injury (TBI) causes more than 30% of all injury-related deaths in the USA annually. The underlying cause and clinical sequela vary among cases. Patients are liable to both acute and chronic changes in the nervous system after such a type of injury. Cerebrovascular disruption has the most common and serious effect in such cases because cerebrovascular autoregulation, which is one of the main determinants of cerebral perfusion pressure, can be effaced in brain injuries even in the absence of evident vascular injury...
February 17, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38353190/cerebellar-infarction-from-a-vertebral-artery-dissection-after-blunt-chest-injury-a-case-report
#14
JOURNAL ARTICLE
Daniella Lamour, Joshua J Solano, Jovana Rutherford, Scott M Alter
INTRODUCTION: Traumatic vertebral artery dissections resulting in stroke are relatively rare occurrences, especially in the absence of classic physical examination findings. CASE REPORT: We present the case of a 30-year-old male with chest pain following a car axle falling onto his chest while trying to change a tire. He was discharged from the emergency department after having a negative workup for thoracic injury. Six hours later, the patient returned with headache and was found to have a cerebellar stroke secondary to vertebral artery dissection...
November 2023: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38352449/histological-comparison-of-repeated-mild-weight-drop-and-lateral-fluid-percussion-injury-models-of-traumatic-brain-injury-tbi-in-female-and-male-rats
#15
Sydney M Vita, Shealan C Cruise, Nicholas W Gilpin, Patricia E Molina
Traumatic brain injury (TBI) heterogeneity has led to the development of several preclinical models, each modeling a distinct subset of outcomes. Selection of an injury model should be guided by the research question and the specific outcome measures of interest. Consequently, there is a need for conducting direct comparisons of different TBI models. Here, we used immunohistochemistry to directly compare the outcomes from two common models, lateral fluid percussion (LFP) and repeat mild weight drop (rmWD), on neuropathology in adult female and male Wistar rats...
February 2, 2024: bioRxiv
https://read.qxmd.com/read/38338936/traumatic-brain-injury-induces-nociceptin-orphanin-fq-and-nociceptin-opioid-peptide-receptor-expression-within-24-hours
#16
JOURNAL ARTICLE
Omar N Al Yacoub, Yong Zhang, Panini S Patankar, Kelly M Standifer
Traumatic brain injury (TBI) is a major cause of mortality and disability around the world, for which no treatment has been found. Nociceptin/Orphanin FQ (N/OFQ) and the nociceptin opioid peptide (NOP) receptor are rapidly increased in response to fluid percussion, stab injury, and controlled cortical impact (CCI) TBI. TBI-induced upregulation of N/OFQ contributes to cerebrovascular impairment, increased excitotoxicity, and neurobehavioral deficits. Our objective was to identify changes in N/OFQ and NOP receptor peptide, protein, and mRNA relative to the expression of injury markers and extracellular regulated kinase (ERK) 24 h following mild (mTBI) and moderate TBI (ModTBI) in wildtype (WT) and NOP receptor-knockout (KO) rats...
January 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38313581/knockdown-of-foxo4-protects-against-ogd-r%C3%A2-induced-cerebral-microvascular-endothelial-cell-injury-and-regulates-the-ampk-nrf2-ho%C3%A2-1-pathway-through-transcriptional-activation-of-ctrp6
#17
JOURNAL ARTICLE
Xiangting Cui, Zhili Li, Yuhua Yuan
Cerebral ischemia is a type of cerebrovascular disease with high disability and mortality rates. The expression of forkhead box protein O4 (FOXO4) in the brain is increased following traumatic brain injury. To the best of our knowledge, however, the role of FOXO4 as well as its mechanism in cerebral ischemia has not been reported so far. For the establishment of an in vitro cellular injury model, human brain microvascular endothelial HCMEC/D3 cells were induced by oxygen-glucose deprivation/reoxygenation (OGD/R)...
March 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38306650/a-comparison-of-computed-tomography-angiography-and-digital-subtraction-angiography-for-the-diagnosis-of-penetrating-cerebrovascular-injury-a-prospective-multicenter-study
#18
JOURNAL ARTICLE
R Michael Meyer, Ramesh Grandhi, Do H Lim, Walid K Salah, Malia McAvoy, Zachary A Abecassis, Robert H Bonow, Melanie Walker, Basavaraj V Ghodke, Sarah T Menacho, Sharon Durfy, Randall M Chesnut, Louis J Kim, Randy S Bell, Michael R Levitt
OBJECTIVE: In this research, the authors sought to characterize the incidence and extent of cerebrovascular lesions after penetrating brain injury in a civilian population and to compare the diagnostic value of head computed tomography angiography (CTA) and digital subtraction angiography (DSA) in their diagnosis. METHODS: This was a prospective multicenter cohort study of patients with penetrating brain injury due to any mechanism presenting at two academic medical centers over a 3-year period (May 2020 to May 2023)...
February 2, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38305993/cerebrovascular-reactivity-prx-and-optimal-cerebral-perfusion-pressure-in-elderly-with-traumatic-brain-injury
#19
JOURNAL ARTICLE
Samuel Lenell, Teodor Svedung Wettervik, Timothy Howells, Anders Hånell, Anders Lewén, Per Enblad
PURPOSE: Cerebral perfusion pressure (CPP) guidance by cerebral pressure autoregulation (CPA) status according to PRx (correlation mean arterial blood pressure (MAP) and intracranial pressure (ICP)) and optimal CPP (CPPopt = CPP with lowest PRx) is promising but little is known regarding this approach in elderly. The aim was to analyze PRx and CPPopt in elderly TBI patients. METHODS: A total of 129 old (≥ 65 years) and 342 young (16-64 years) patients were studied using monitoring data for MAP and ICP...
February 2, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38304806/ginkgolide-a-attenuated-apoptosis-via-inhibition-of-oxidative-stress-in-mice-with-traumatic-brain-injury
#20
JOURNAL ARTICLE
Lei Zhu, Zhengwei Li, Liping Sheng, Fengfei Zhang, Wei Ji
Traumatic brain injury (TBI) is the main cause of death among young adults and the main cause of mortality and disability for all ages groups worldwide. Ginkgolides terpenoid compounds unique to Ginkgo biloba, which have protective effects on cardiovascular and cerebrovascular diseases. The aim of this study is to investigate whether ginkgolide A (GA) can improve TBI in mice and whether it can alleviate cell apoptosis in the brain of TBI mice by reducing oxidative stress. Mice received TBI and GA administration for 7 days...
January 30, 2024: Heliyon
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