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histone acetyltransferase

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https://www.readbyqxmd.com/read/29457866/epigenetic-effects-of-metformin-from-molecular-mechanisms-to-clinical-implications
#1
REVIEW
S C Bridgeman, G C Ellison, P E Melton, P Newsholme, Cds Mamotte
There is a growing body of evidence that links epigenetic modifications to type 2 diabetes. Researchers have more recently investigated effects of commonly used medications, including those prescribed for diabetes, on epigenetic processes. This work reviews the influence of the widely used antidiabetic drug metformin on epigenomics, microRNA levels and subsequent gene expression and potential clinical implications. Metformin may influence the activity of numerous epigenetic modifying enzymes, mostly via modulating the activation of AMP-activated protein kinase (AMPK)...
February 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29455928/transcriptional-regulation-of-the-warburg-effect-in-cancer-by-six1
#2
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth...
February 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29454793/p300-acetyltransferase-mediates-stiffness-induced-activation-of-hepatic-stellate-cells-into-tumor-promoting-myofibroblasts
#3
Changwei Dou, Zhikui Liu, Kangsheng Tu, Hongbin Zhang, Chen Chen, Usman Yaqoob, Yuanguo Wang, Jialing Wen, Jan van Deursen, Delphine Sicard, Daniel Tschumperlin, Hongzhi Zou, Wei-Chien Huang, Raul Urrutia, Vijay H Shah, Ningling Kang
BACKGROUND & AIMS: Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of liver metastases by differentiating into matrix-producing myofibroblasts. We investigated whether stiffness due to the presence of tumors increases activation of HSCs into myofibroblasts and their tumor-promoting effects, as well as the role of E1A binding protein p300 (EP300 or p300), a histone acetyltransferase that regulates transcription, in these processes. METHODS: HSCs were isolated from liver tissues of patients, mice in which the p300 gene was flanked by 2 loxP sites (p300F/F mice), and p300+/+ mice (controls)...
February 15, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29453316/brd1-mediated-acetylation-promotes-integrin-%C3%AE-v-gene-expression-via-interaction-with-sulfatide
#4
Qian Qian Cai, Yi Wei Dong, Bing Qi, Xiao-Ting Shao, Rong Wang, Zhong Yi Chen, Bao Mei He, Xing Zhong Wu
Integrin αV (ITGAV) gene expression is often dysregulated in cancers especially in hepatocellular carcinoma (HCC); however, the mechanism of regulation is poorly understood. Here, it is demonstrated that sulfatide activated integrin αV gene transcription, through histone H3K9/14 acetylation at the promoter, and high integrin αV expression are closely associated with poor prognosis. To elucidate the mechanism of regulation of acetylation, sulfatide-bound proteins were screened by mass spectrometry (MS), and BRD1 (bromodomain containing protein 1) was identified as an interacting protein that also co-localized with sulfatide in HCC cells...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29448097/selective-degradation-of-bet-proteins-with-dbet1-a-proteolysis-targeting-chimera-potently-reduces-pro-inflammatory-responses-in-lipopolysaccharide-activated-microglia
#5
Kelly M DeMars, Changjun Yang, Carolina I Castro-Rivera, Eduardo Candelario-Jalil
Bromodomain and extraterminal (BET) proteins are essential to pro-inflammatory gene transcription. The BET family proteins, BRD2, BRD3, BRD4, and testis-specific BRDT, couple chromatin remodeling to gene transcription, acting as histone acetyltransferases, scaffolds for transcription complexes, and markers of histone acetylation. To initiate an inflammatory response, cells undergo de novo gene transcription requiring histone-modifying proteins to make DNA wrapped around histones more or less readily available to transcription complexes...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29432129/identification-of-two-distinct-classes-of-the-human-ino80-complex-genome-wide
#6
John S Runge, Jesse R Raab, Terry Magnuson
Chromatin remodeling and histone modifying enzymes play a critical role in shaping the regulatory output of a cell. Although much is known about these classes of proteins, identifying the mechanisms by which they coordinate gene expression programs remains an exciting topic of investigation. One factor that may contribute to the targeting and activity of chromatin regulators is local chromatin landscape. We leveraged genomic approaches and publically-available datasets to characterize the chromatin landscape at targets of the human INO80 chromatin remodeling complex (INO80-C)...
February 5, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29431744/a-histone-deacetylase-3-dependent-pathway-delimits-peripheral-myelin-growth-and-functional-regeneration
#7
Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski, Q Richard Lu
Deficits in Schwann cell-mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain elusive. Here, through small-molecule screening focusing on epigenetic modulators, we identified histone deacetylase 3 (HDAC3; a histone-modifying enzyme) as a potent inhibitor of peripheral myelinogenesis. Inhibition of HDAC3 enhanced myelin growth and regeneration and improved functional recovery after peripheral nerve injury in mice...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29423916/epiproteome-profiling-of-cadmium-transformed-human-bronchial-epithelial-cells-by-quantitative-histone-post-translational-modification-enzyme-linked-immunosorbent-assay
#8
Zhan-Ling Liang, Dan-Dan Wu, Yue Yao, Fei-Yuan Yu, Lei Yang, Heng Wee Tan, Machteld N Hylkema, Marianne G Rots, Yan-Ming Xu, Andy T Y Lau
Cadmium (Cd), a carcinogenic toxic metal, is pervasively distributed in the soil, water and air. Chronic exposure to Cd has been correlated to lung disease development including cancers. Although many studies have been conducted to investigate the proteome response of cells challenged with Cd, the epiproteomic responses (i.e., global histone post-translational modifications [PTMs]), particularly in human lung cells, are largely unexplored. Here, we provide an epiproteome profiling of human bronchial epithelial cells (BEAS-2B) chronically treated with cadmium chloride (CdCl2 ), with the aim of identifying global epiproteomic signatures in response to Cd epigenotoxicity...
February 9, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29423010/inhibition-of-n-acetyltransferase-10-using-remodelin-attenuates-doxorubicin-resistance-by-reversing-the-epithelial-mesenchymal-transition-in-breast-cancer
#9
Ji Wu, Hong Zhu, Jianqiang Wu, Wei Chen, Xiaoqing Guan
Development of resistance to doxorubicin-based chemotherapy limits curative effect in breast cancer (BC). N-acetyltransferase 10 (NAT10), a nucleolar protein involved in histone acetylation, is overexpressed in several cancers. We investigated whether NAT10 is involved in doxorubicin resistance in BC and explored the potential mechanisms. Remodelin, a NAT10 inhibitor, and a NAT10 small interfering RNA (siRNA) were used to inhibit NAT10; both remodelin and the NAT10 siRNA reduced cell viability and attenuated doxorubicin resistance in four BC cell lines...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29421311/cross-pathway-control-gene-cpc1-gcn4-coordinates-with-histone-acetyltransferase-gcn5-to-regulate-catalase-3-expression-under-oxidative-stress-in-neurospora-crassa
#10
Shaohua Qi, Lingaonan He, Qin Zhang, Qing Dong, Yajun Wang, Qiuying Yang, Chaoguang Tian, Qun He, Ying Wang
Catalase is an important enzyme found in nearly all aerobic organisms and plays an essential role in protecting cells from oxidative damage by catalyzing the degradation of hydrogen peroxide into water and oxygen. In filamentous fungus Neurospora crassa, the expression levels of catalases are rigorously regulated by morphogenetic transition during growth and development in cells. Our study revealed that catalase-3 transcription is positively regulated by histone acetyltransferase GCN5 and the cross-pathway control gene cpc-1, as the cat-3 expression level is significantly decreased in gcn5KO and cpc-1 (j-5) mutants...
February 5, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29417710/gcn5-dependent-histone-h3-acetylation-and-gene-activity-is-required-for-the-asexual-development-and-virulence-of-beauveria-bassiana
#11
Qing Cai, Juan-Juan Wang, Bo Fu, Sheng-Hua Ying, Ming-Guang Feng
Gcn5 is a core histone acetyltransferase that catalyzes histone H3 acetylation on N-terminal lysine residues in yeasts and was reported to catalyze H3K9/K14 acetylation required for activating asexual development in Aspergillus. Here, we report a localization of Gcn5 ortholog in the nucleus and cytoplasm of Beauveria bassiana, a fungal insect pathogen. Deletion of gcn5 led to hypoacetylated H3 at K9/14/18/27 and 97% reduction in conidiation capacity as well as severe defects in colony growth and conidial thermotolerance...
February 7, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29416009/epigenetic-inhibition-of-wnt-pathway-suppresses-osteogenic-differentiation-of-bmscs-during-osteoporosis
#12
Huan Jing, Xiaoxia Su, Bo Gao, Yi Shuai, Ji Chen, Zhihong Deng, Li Liao, Yan Jin
Disrupted Wnt signaling in osteoblastic-lineage cells leads to bone formation defect in osteoporosis. However, the factors repressing Wnt signaling are unclear. In our study, we found that Wnt signaling was suppressed persistently in bone marrow-derived mesenchymal stem cells (BMSCs) during osteoporosis. Accordingly, histone acetylation levels on Wnt genes (Wnt1, Wnt6, Wnt10a, and Wnt10b) were declined in BMSCs from OVX mice. By screening the family of histone acetyltransferase, we identified that GCN5 expression increased during osteogenic differentiation of BMSCs, whereas decreased after osteoporosis...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29414790/histone-acetyltransferase-7-kat7-dependent-intragenic-histone-acetylation-regulates-endothelial-cell-gene-regulation
#13
Matthew S Yan, Paul J Turgeon, Hon Sum Jeffrey Man, Michelle K Dubinsky, Jr Jyun David Ho, Suzan El-Rass, You-Dong Wang, Xiao-Yan Wen, Philip A Marsden
Although the functional role of chromatin marks at promoters in mediating cell-restricted gene expression has been well characterized, the role of intragenic chromatin marks is not well understood, especially in endothelial cell (EC) gene expression. Here, we characterized the histone H3 and H4 acetylation profiles of 19 genes with EC-enriched expression via loci-wide chromatin immunoprecipitation followed by ultra high resolution (5 bp) tiling array analysis in ECs versus non-ECs throughout their genomic loci...
February 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29412739/mc1568-enhances-histone-acetylation-during-oocyte-meiosis-and-improves-development-of-somatic-cell-nuclear-transfer-embryos-in-pig
#14
Huili Wang, Wei Cui, Chunhua Meng, Jun Zhang, Yinxia Li, Yong Qian, Guangdong Xing, Dongmin Zhao, Shaoxian Cao
An increasing number of studies have revealed that histone deacetylase (HDAC) mediated histone deacetylation is important for mammalian oocyte development. However, nonselective HDAC inhibitors (HDACi) were applied in most studies; the precise functions of specific HDAC classes during meiosis are poorly defined. In this study, the class IIa-specific HDACi MC1568 was used to reveal a crucial role of class IIa HDACs in the regulation of histone deacetylation during porcine oocyte meiosis. Besides, the functions of HDACs and histone acetyltransferases in regulating the balance of histone acetylation/deacetylation were also confirmed during oocyte maturation...
February 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29396115/a-lipid-transfer-protein-signaling-axis-exerts-dual-control-of-cell-cycle-and-membrane-trafficking-systems
#15
Jin Huang, Carl J Mousley, Louis Dacquay, Nairita Maitra, Guillaume Drin, Chong He, Neale D Ridgway, Ashutosh Tripathi, Michael Kennedy, Brian K Kennedy, Wenshe Liu, Kristin Baetz, Michael Polymenis, Vytas A Bankaitis
Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits phosphatidylinositol transfer protein (Sec14)-dependent membrane trafficking through the trans-Golgi (TGN)/endosomal network. We now report that Kes1, and select other ORPs, execute cell-cycle control activities as functionally non-redundant inhibitors of the G1/S transition when cells confront nutrient-poor environments and promote replicative aging. Kes1-dependent cell-cycle regulation requires the Greatwall/MASTL kinase ortholog Rim15, and is opposed by Sec14 activity in a mechanism independent of Kes1/Sec14 bulk membrane-trafficking functions...
January 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29382722/the-scaffolding-protein-jade1-physically-links-the-acetyltransferase-subunit-hbo1-with-its-histone-h3-h4-substrate
#16
Joseph Han, Catherine Lachance, Michael D Ricketts, Cheryl E McCullough, Morgan Gerace, Ben E Black, Jacques Côté, Ronen Marmorstein
The human enzyme histone acetyltransferase binding to ORC1 (HBO1) regulates DNA replication, cell proliferation, and development. HBO1 is part of a multiprotein histone acetyltransferase (HAT) complex that also contains inhibitor of growth family member (ING) 4/5, MYST/Esa1-associated factor (MEAF) 6, and the scaffolding proteins Jade family PHD finger (JADE) 1/2/3 or bromodomain and PHD finger-containing protein (BRPF) 2/3 to acetylate histone H4 H4K5/8/12 or H3K14, respectively. Within this four-protein complex, JADE1  determines histone H4 substrate specificity of the HBO1-HAT complex...
January 30, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29382514/-epigenetic-alterations-in-acute-lymphoblastic-leukemia
#17
REVIEW
María Del Pilar Navarrete-Meneses, Patricia Pérez-Vera
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. It is well-known that genetic alterations constitute the basis for the etiology of ALL. However, genetic abnormalities are not enough for the complete development of the disease, and additional alterations such as epigenetic modifications are required. Such alterations, like DNA methylation, histone modifications, and noncoding RNA regulation have been identified in ALL. DNA hypermethylation in promoter regions is one of the most frequent epigenetic modifications observed in ALL...
July 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29366253/nadph-oxidase-5-expression-is-regulated-by-histone-acetyltransferase-1-and-p300-dependent-in-human-macrophages
#18
Mihaela-Loredana Antonescu, Simona-Adriana Manea, Maya Simionescu, Adrian Manea
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29362481/enhancer-of-polycomb-maintains-germline-activity-and-genome-integrity-in-drosophila-testis
#19
Lijuan Feng, Zhen Shi, Jing Xie, Binbin Ma, Xin Chen
Tissue homeostasis depends on the ability of tissue-specific adult stem cells to maintain a balance between proliferation and differentiation, as well as ensure DNA damage repair. Here, we use the Drosophila male germline stem cell system to study how a chromatin factor, enhancer of polycomb [E(Pc)], regulates the proliferation-to-differentiation (mitosis-to-meiosis) transition and DNA damage repair. We identified two critical targets of E(Pc). First, E(Pc) represses CycB transcription, likely through modulating H4 acetylation...
January 23, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29362416/creb-binding-protein-plays-key-roles-in-juvenile-hormone-action-in-the-red-flour-beetle-tribolium-castaneum
#20
Jingjing Xu, Amit Roy, Subba Reddy Palli
Juvenile hormones (JH) and ecdysteroids regulate many biological and metabolic processes. CREB-binding protein (CBP) is a transcriptional co-regulator with histone acetyltransferase (HAT) activity. Therefore, CBP is involved in activation of many transcription factors that regulate expression of genes associated with postembryonic development in insects. However, the function of CBP in JH action in insects is not well understood. Hence, we studied the role of CBP in JH action in the red flour beetle, Tribolium castaneum and the Tribolium cell line...
January 23, 2018: Scientific Reports
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