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Coagulase negative sepsis and neonate

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https://www.readbyqxmd.com/read/28088587/late-onset-neonatal-sepsis-in-arab-states-in-the-gulf-region-two-year-prospective-study
#1
Majeda S Hammoud, Abdullah Al-Taiar, Sameer Y Al-Abdi, Hussain Bozaid, Anwar Khan, Laila M AlMuhairi, Moghis Ur Rehman
OBJECTIVES: This study aimed to investigate the incidence of Late-Onset Sepsis (LOS) in neonatal intensive care units (NICUs) in Arab states in the gulf region and describe the main causative organisms and their antibiotic resistance. METHODS: Observational prospective cohort study was conducted over two-year period in five NICUs in Kuwait, Saudi Arabia and United Arab Emirates. LOS was defined as the growth of a single potentially pathogenic organism from blood or cerebrospinal fluid in infants >3days of age with clinical and laboratory findings consistent with infection...
January 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28018320/single-molecule-sequencing-pacbio-of-the-staphylococcus-capitis-nrcs-a-clone-reveals-the-basis-of-multidrug-resistance-and-adaptation-to-the-neonatal-intensive-care-unit-environment
#2
Patrícia Martins Simões, Hajar Lemriss, Yann Dumont, Sanâa Lemriss, Jean-Philippe Rasigade, Sophie Assant-Trouillet, Azeddine Ibrahimi, Saâd El Kabbaj, Marine Butin, Frédéric Laurent
The multi-resistant Staphylococcus capitis clone NRCS-A has recently been described as a major pathogen causing nosocomial, late-onset sepsis (LOS) in preterm neonates worldwide. NRCS-A representatives exhibit an atypical antibiotic resistance profile. Here, the complete closed genome (chromosomal and plasmid sequences) of NRCS-A prototype strain CR01 and the draft genomes of three other clinical NRCS-A strains from Australia, Belgium and the United Kingdom are annotated and compared to available non-NRCS-A S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27931193/coagulase-negative-staphylococcal-sepsis-in-neonates-do-we-need-to-adapt-vancomycin-dose-or-target
#3
Helgi Padari, Kersti Oselin, Tõnis Tasa, Tuuli Metsvaht, Krista Lõivukene, Irja Lutsar
BACKGROUND: Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets of vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed for the attainment of AUC/MIC > 400 and AUC/MIC > 300 in neonates with sepsis and correlate these targets with recommended doses and treatment outcome. METHODS: Neonates who had Vancomycin therapeutic drug monitoring (TDM) performed between January 1, 2010 and December 31, 2012 were studied...
December 8, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27776490/neonatal-bloodstream-infections-in-a-ghanaian-tertiary-hospital-are-the-current-antibiotic-recommendations-adequate
#4
Appiah-Korang Labi, Noah Obeng-Nkrumah, Stephanie Bjerrum, Christabel Enweronu-Laryea, Mercy Jemima Newman
BACKGROUND: Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS: A review of neonatal blood cultures submitted to the microbiology department of the Korle-Bu Teaching Hospital was conducted from January 2010 through December 2013. We assessed the prevalence of bacteria and fungi involved in BSI and the susceptibility coverage of recommended empiric antibiotics by Ghana Standard Treatment guidelines and the WHO recommendations for managing neonatal sepsis...
October 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27721284/the-rising-trend-of-coagulase-negative-staphylococci-in-neonatal-septicemia
#5
Vijaya Shivanna, S R Sunkappa, D Venkatesha
Neonatal septicemia is one of the leading causes of neonatal mortality and morbidity worldwide. Hence, the present study was undertaken to isolate the bacteria causing neonatal sepsis and determine their antibiotic susceptibility pattern. Fifty neonates suspected to have septicemia were screened for 2 months (July and August 2014). Out of 50 specimen, 15 (30%) were blood culture positive. Coagulase-negative staphylococci was the most common isolate (10, 66.6%), with 60% (6 isolates) methicillin resistance. In view of the increasing antibiotic resistance, periodic surveillance should be conducted to control the emergence and spread of antimicrobial resistance...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27633433/characterisation-and-antimicrobial-resistance-of-sepsis-pathogens-in-neonates-born-in-tertiary-care-centres-in-delhi-india-a-cohort-study
#6
(no author information available yet)
BACKGROUND: Sepsis is one of the most common causes of neonatal deaths globally. Most sepsis-related deaths occur in low-income and middle-income countries, where the epidemiology of neonatal sepsis remains poorly understood. Most of these countries lack proper surveillance networks, hampering accurate assessment of the burden of sepsis, implementation of preventive measures, and investment in research. We report results of neonates born in hospital from a multicentre collaboration on neonatal sepsis...
October 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27583393/association-between-birth-route-and-late-onset-sepsis-in-very-preterm-neonates
#7
F Olivier, V Bertelle, P S Shah, C Drolet, B Piedboeuf
OBJECTIVE: To evaluate the association between birth route and late-onset sepsis (LOS), and coagulase-negative Staphylococcal (CONS)-related LOS in preterm neonates. STUDY DESIGN: In this observational study, data from 20,038 infants born between 22 and 32 weeks' gestation and admitted to Canadian neonatal intensive care units between 2010 and 2014 were analyzed retrospectively. The impact of birth route on LOS was assessed using univariate analysis and multiple logistic regression...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27539482/the-impact-of-a-sepsis-quality-improvement-project-on-neurodisability-rates-in-very-low-birthweight-infants
#8
Jonathan W Davis, David Odd, Sally Jary, Karen Luyt
OBJECTIVE: Very low birthweight (VLBW; <1500 g) infants with late-onset sepsis (LOS) have an increased risk of neurodisability. Care bundles to reduce bloodstream infections in neonatal intensive care unit (NICU) are effective in reducing LOS. Our aim was to determine if a sepsis reduction bundle introduced through a quality improvement project would impact neurodevelopmental outcomes in VLBW infants. DESIGN: Cohort study. SETTING: Level 3 regional NICU in the South West of England...
August 18, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27527563/serum-levels-of-vancomycin-is-there-a-prediction-using-doses-in-mg-kg-day-or-m-2-day-for-neonates
#9
Roberta Maia de Castro Romanelli, Lêni Márcia Anchieta, Juliana Chaves Abreu Fernandes, Mariana Antunes Faria Lima, Taís Marina de Souza, Viviane Rosado, Wanessa Trindade Clemente, Paulo Augusto Moreira Camargos
Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m(2)/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013...
September 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27500793/pathogen-and-antimicrobial-resistance-profiles-of-culture-proven-neonatal-sepsis-in-southwest-china-1990-2014
#10
Qi Lu, Min Zhou, Yan Tu, Yao Yao, Jialin Yu, Shupeng Cheng
AIM: Neonatal sepsis (NS) sustains high mortality and morbidity in China, but data on the epidemiology and antimicrobial resistance patterns of NS pathogens are limited. METHODS: The clinical features, aetiology and antimicrobial resistance of culture-proven NS were analysed over a period of 25 years in the metropolitan city of Chongqing in Southwest China. RESULTS: The occurrence rates of neonatal early-onset sepsis (EOS) were found to gradually decrease while late-onset sepsis (LOS) was kept stable from 1990 to 2014...
October 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27472282/clinical-relevance-of-pathogens-detected-by-multiplex-pcr-in-blood-of-very-low-birth-weight-infants-with-suspected-sepsis-multicentre-study-of-the-german-neonatal-network
#11
Birte Tröger, Christoph Härtel, Jan Buer, Michael Dördelmann, Ursula Felderhoff-Müser, Thomas Höhn, Nico Hepping, Georg Hillebrand, Angela Kribs, Janina Marissen, Dirk Olbertz, Peter-Michael Rath, Susanne Schmidtke, Jens Siegel, Egbert Herting, Wolfgang Göpel, Joerg Steinmann, Anja Stein
INTRODUCTION: In the German Neonatal Network (GNN) 10% of very-low-birth weight infants (VLBWI) suffer from blood-culture confirmed sepsis, while 30% of VLBWI develop clinical sepsis. Diagnosis of sepsis is a difficult task leading to potential over-treatment with antibiotics. This study aims to investigate whether the results of blood multiplex-PCR (SeptiFast®) for common sepsis pathogens are relevant for clinical decision making when sepsis is suspected in VLBWI. METHODS: We performed a prospective, multi-centre study within the GNN including 133 VLBWI with 214 episodes of suspected late onset sepsis (LOS)...
2016: PloS One
https://www.readbyqxmd.com/read/27384625/-microbiological-and-therapeutic-characteristics-of-confirmed-neonatal-sepsis-at-a-hospital-in-lima-peru
#12
Giancarlo Alvarado-Gamarra, Katherine M Alcalá-Marcos, Diego M Abarca-Alfaro, Victoria Bao-Castro
OBJECTIVES: To describe the microbiological and therapeutic characteristics of confirmed neonatal sepsis, and determineits incidence and mortality, at the National Hospital Arzobispo Loayza (HNAL) from 2011 to 2012, Lima, Peru. MATERIALS AND METHODS: Retrospective longitudinal study. It was performed a monitoring to newborns with probable sepsis, and assessed the results from positive blood cultures. The newborns' characteristics were obtained from medical records...
March 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27262336/treatment-options-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-neonates
#13
REVIEW
Despoina Gkentzi, Soultana Kolyva, Iris Spiliopoulou, Markos Marangos, Gabriel Dimitriou
BACKGROUND: Coagulase-negative staphylococci (CoNS) are the leading cause of late-onset sepsis in neonatal intensive-care units (NICUs). Despite adequate therapeutic levels and in vivo susceptibility, vancomycin is not always adequate in clearing CoNS bacteremias and other theurapeutic regimens are warranted especially when dealing with persistent CoNS bacteremias. METHODS: Retrospective analysis of neonates with persistent CoNS bacteremias in a tertiary NICU in two study periods (January 2006 to December 2007 and January 2011 to December 2012)...
2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27183717/-ability-of-staphylococcus-of-various-strains-to-create-biofilms-and-their-effect-on-human-body-cells
#14
M A Kornienko, V N Kopyltsov, N V Shevlyagina, L V Didenko, L A Lyubasovskaya, T V Priputnevich, E N Ilina
The urgency of the staphylococcus research is due to its ability to cause severe infections: softtissue infections, endocarditis, sepsis, toxic shock syndrome, and food poisoning. Coagulase-positive Staphylococcus aureus is the main infection agent of intrahospital infections. This agent has many factors of pathogenicity, which are well known. Among the coagulase-negative staphylococcus (CNS) strains, S. haemolyticus and S. epidermidis are clinically important, because they cause infections in patients with weak immune system...
2016: Molekuliarnaia Genetika, Mikrobiologiia i Virusologiia
https://www.readbyqxmd.com/read/27112033/empirical-antimicrobial-therapy-for-late-onset-sepsis-in-a-neonatal-unit-with-high-prevalence-of-coagulase-negative-staphylococcus
#15
Roberta Maia de Castro Romanelli, Lêni Márcia Anchieta, Ana Carolina Bueno E Silva, Lenize Adriana de Jesus, Viviane Rosado, Wanessa Trindade Clemente
OBJECTIVE: The aim of this study was to compare two different empiric treatments for late-onset neonatal sepsis, vancomycin and oxacillin, in a neonatal intensive care unit with a high prevalence of coagulase-negative Staphylococcus. METHODS: A cross-sectional study was conducted in an neonatal intensive care unit from 2011 to 2014. Data from the medical records of at-risk newborns were collected daily. Infections were defined according to the National Health Surveillance Agency criteria...
September 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27031259/etiology-antibiotic-resistance-and-risk-factors-for-neonatal-sepsis-in-a-large-referral-center-in-zambia
#16
Mwila Kabwe, John Tembo, Lophina Chilukutu, Moses Chilufya, Francis Ngulube, Chileshe Lukwesa, Monica Kapasa, Virve Enne, Hannah Wexner, Lawrence Mwananyanda, Davidson H Hamer, Sylvestor Sinyangwe, Yusuf Ahmed, Nigel Klein, Markus Maeurer, Alimuddin Zumla, Matthew Bates
BACKGROUND: In sub-Saharan Africa, there is scanty data on the causes of neonatal sepsis and antimicrobial resistance among common invasive pathogens that might guide policy and practice. METHODS: A cross-sectional observational prevalence and etiology study of neonates with suspected sepsis admitted to the neonatal intensive care unit, University Teaching Hospital, Lusaka, Zambia, between October 2013 and May 2014. Data from blood cultures and phenotypic antibiotic susceptibility testing were compared with multivariate analysis of risk factors for neonatal sepsis...
July 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27005713/bacteriological-profile-of-neonatal-sepsis-in-neonatal-intermediate-care-unit-of-central-paediatric-referral-hospital-in-nepal
#17
R H Chapagain, R Acharya, N Shrestha, B R Giri, B B Bagale, M Kayastha
BACKGROUND: Sepsis is one of the leading causes of neonatal morbidity and mortality. Because of difference in local epidemiology and possible variation with time, regular monitoring and updates on pathogen and their antimicrobial sensitivity pattern is important for prevention and treatment. METHODS: A retrospective descriptive study was carried out among cases of neonatal sepsis admitted in neonatal intermediate care unit of Kanti Children's hospital from August 2014 to August 2015...
September 2015: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/26984074/the-clinical-characteristics-of-neonatal-sepsis-infection-in-southwest-china
#18
Yongmei Jiang, Linghan Kuang, Haijuan Wang, Lingping Li, Wei Zhou, Mingyuan Li
OBJECTIVE: To identify the pathogens responsible for neonatal sepsis in a high-volume women and children's hospital in Southwest China. METHODS: We retrospectively studied 133 neonates who were admitted to the West China Women and Children's Hospital between 2008 and 2012 for sepsis. The clinical characteristics of the patients were recorded, and the antibiotic sensitivities of the isolated bacteria were determined. RESULTS: All of the included patients had clinical symptoms of sepsis, and subsequent blood cultures confirmed the infection...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26858036/bacteriological-spectrum-and-antimicrobial-susceptibility-pattern-of-neonatal-septicaemia-in-a-tertiary-care-hospital-of-north-india
#19
Mamta Lamba, Rajni Sharma, Deepak Sharma, Mukesh Choudhary, Rakesh Kumar Maheshwari
BACKGROUND: Neonatal septicaemia is a clinical entity that is characterised by systemic signs and symptoms of infection and accompanied by bacteraemia in first 4 weeks of life and is one of the four leading causes of neonatal mortality and morbidity in India. AIM: To determine the bacterial spectrum and antimicrobial susceptibility pattern of neonatal septicaemia in a tertiary care hospital of North India. MATERIALS AND METHODS: In this prospective observational study, 850 blood samples were collected and processed from clinically suspected neonates according to standard laboratory protocol...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26776121/bacteriological-profile-and-antibiotic-sensitivity-pattern-of-neonatal-septicaemia-in-a-rural-tertiary-care-hospital-in-north-india
#20
S Thakur, K Thakur, A Sood, S Chaudhary
BACKGROUND: There is not much published literature on neonatal septicemia available for the Sub-Himalayan region of North India. Hence, we undertook this study to find out the bacteriological profile and antibiotic sensitivity pattern of neonatal septicemia in the neonatal Intensive Care Unit. MATERIAL AND METHODS: Blood cultures were performed for all clinically suspected neonatal septicemia cases for 1-year. Identification of all pathogenic isolates was followed by antibiotic sensitivity testing...
January 2016: Indian Journal of Medical Microbiology
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