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Coagulase negative sepsis and neonate

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https://www.readbyqxmd.com/read/28440985/-early-neonatal-sepsis-and-associated-factors
#1
Roberto Anaya-Prado, Cuauhtémoc Valero-Padilla, Augusto Sarralde-Delgado, Jorge Manuel Sánchez-González
BACKGROUND: Early-onset neonatal sepsis (EONS) is an infectious disease of low incidence but high morbidity and mortality with severe consequences to the newborn prognosis. Identifying the associated factors related to EONS allows to start a timely treatment and to take preventive measures. METHODS: In this case and controls study we identified all the newborns (NB) with and without EONS (cases and controls), diagnosed through blood culture in a period of three years...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28421643/empiric-antibiotic-regimens-for-neonatal-sepsis-in-australian-and-new-zealand-neonatal-intensive-care-units
#2
Jeremy P Carr, David P Burgner, Rohan S Hardikar, Jim P Buttery
AIM: Neonatal sepsis remains an important cause of morbidity and mortality, and requires prompt empiric treatment. However, only a minority of babies who receive antibiotics for suspected sepsis have an infection. Antimicrobial exposure in infancy has important short- and long-term consequences. There is no consensus regarding empirical antimicrobial regimens. METHODS: The study included a survey of empiric antimicrobial regimens in all tertiary neonatal intensive care units in Australia and New Zealand in 2013-2014...
April 19, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28272077/changing-trend-in-bacterial-etiology-and-antibiotic-resistance-in-sepsis-of-intramural-neonates-at-a-tertiary-care-hospital
#3
M P Roy, M Bhatt, V Maurya, S Arya, R Gaind, H K Chellani
BACKGROUND: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates. MATERIALS AND METHODS: A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999-2014, divided into five phases...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28221122/worldwide-endemicity-of-a-multidrug-resistant-staphylococcus-capitis-clone-involved-in-neonatal-sepsis
#4
Marine Butin, Patricia Martins-Simões, Jean-Philippe Rasigade, Jean-Charles Picaud, Frédéric Laurent
A multidrug-resistant Staphylococcus capitis clone, NRCS-A, has been isolated from neonatal intensive care units in 17 countries throughout the world. S. capitis NRCS-A prevalence is high in some neonatal intensive care units in France. These data highlight the worldwide endemicity and epidemiologic relevance of this multidrug-resistant, coagulase-negative staphylococci clone.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28196391/pentoxifylline-treatment-of-very-low-birth-weight-neonates-with-nosocomial-sepsis
#5
Şahin Hamilçıkan, Emrah Can, Övgü Büke, Meltem Erol, Özlem Bostan Gayret
Objective The objective of this study was to assess the result of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in very low birth weight (VLBW) preterm neonates with nosocomial sepsis. Methods For the 18 VLBW preterm neonates, as an adjunct therapy to antibiotics regimens, pentoxifylline (5 mg/kg/h for 6 hours) was administered to premature infants with sepsis on 3 successive days. Clinical and laboratory parameters were recorded before and after treatment. Results Following pentoxifylline therapy, the immature-to-total neutrophil ratio and C-reactive protein (CRP) levels were significantly decreased, while the blood pH and base excess were significantly increased (p < 0...
February 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28178107/late-onset-neonatal-sepsis-a-10-year-review-from-north-queensland-australia
#6
Harsha Gowda, Robert Norton, Andrew White, Yogavijayan Kandasamy
OBJECTIVE: Late-onset sepsis (LOS) in neonates contributes significantly to both morbidity and mortality. To determine the incidence of LOS, risk factors for disease, and the impact on subsequent hospital course, we evaluated a cohort of 6340 neonates admitted to the neonatal intensive care unit and of neonates (3-28 days) admitted from the community between January 2005 and January 2016. METHODS: This was a retrospective case review of all neonates admitted with suspected LOS who had positive blood culture and/or cerebrospinal fluid (CSF) cultures, for an organism determined to be a pathogen...
February 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28159945/simultaneous-two-site-blood-culture-in-diagnosis-of-neonatal-sepsis
#7
Priya Tomar, Amit Garg, Rashee Gupta, Abhishek Singh, Navratan Kumar Gupta, Amit Upadhyay
OBJECTIVE: To evaluate efficacy of two blood cultures taken simultaneously from two different sites as compared to standard practice of single blood culture in diagnosis of neonatal sepsis. Study. DESIGN: Prospective cohort study. SETTING: A tertiary care center of North India from August 2014-July 2015. PARTICIPANTS: 475 neonates admitted to our intensive care unit with suspected sepsis. INTERVENTION: Two blood cultures drawn from two different peripheral veins in patients with suspected neonatal sepsis...
February 2, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28143490/pathogenic-bacteria-distributions-and-drug-resistance-analysis-in-96-cases-of-neonatal-sepsis
#8
Huaifu Dong, Huiping Cao, Haiyan Zheng
BACKGROUND: This study aimed to summarize common pathogens and associated drug resistance in neonatal sepsis (NS). METHODS: Blood culture and drug sensitivity results from 96 NS cases treated from January 2010 to August 2014 were retrospectively analyzed. RESULTS: A total of 97 pathogenic bacteria were detected from these 96 NS cases; Gram-positive cocci accounted for 76.3% of the cases, among which 70.1% involved coagulase-negative staphylococcus (CONS), whereas Gram-negative bacilli and fungi accounted for 19...
February 1, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28088587/late-onset-neonatal-sepsis-in-arab-states-in-the-gulf-region-two-year-prospective-study
#9
Majeda S Hammoud, Abdullah Al-Taiar, Sameer Y Al-Abdi, Hussain Bozaid, Anwar Khan, Laila M AlMuhairi, Moghis Ur Rehman
OBJECTIVES: This study aimed to investigate the incidence of late-onset sepsis (LOS) in neonatal intensive care units (NICUs) in Arab states in the Gulf region and to describe the main causative organisms and their antibiotic resistance. METHODS: This observational prospective cohort study was conducted over a 2-year period in five NICUs in Kuwait, Saudi Arabia, and the United Arab Emirates. LOS was defined as the growth of a single potentially pathogenic organism from blood or cerebrospinal fluid in infants >3days of age with clinical and laboratory findings consistent with infection...
February 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28018320/single-molecule-sequencing-pacbio-of-the-staphylococcus-capitis-nrcs-a-clone-reveals-the-basis-of-multidrug-resistance-and-adaptation-to-the-neonatal-intensive-care-unit-environment
#10
Patrícia Martins Simões, Hajar Lemriss, Yann Dumont, Sanâa Lemriss, Jean-Philippe Rasigade, Sophie Assant-Trouillet, Azeddine Ibrahimi, Saâd El Kabbaj, Marine Butin, Frédéric Laurent
The multi-resistant Staphylococcus capitis clone NRCS-A has recently been described as a major pathogen causing nosocomial, late-onset sepsis (LOS) in preterm neonates worldwide. NRCS-A representatives exhibit an atypical antibiotic resistance profile. Here, the complete closed genome (chromosomal and plasmid sequences) of NRCS-A prototype strain CR01 and the draft genomes of three other clinical NRCS-A strains from Australia, Belgium and the United Kingdom are annotated and compared to available non-NRCS-A S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27931193/coagulase-negative-staphylococcal-sepsis-in-neonates-do-we-need-to-adapt-vancomycin-dose-or-target
#11
Helgi Padari, Kersti Oselin, Tõnis Tasa, Tuuli Metsvaht, Krista Lõivukene, Irja Lutsar
BACKGROUND: Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets of vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed for the attainment of AUC/MIC > 400 and AUC/MIC > 300 in neonates with sepsis and correlate these targets with recommended doses and treatment outcome. METHODS: Neonates who had Vancomycin therapeutic drug monitoring (TDM) performed between January 1, 2010 and December 31, 2012 were studied...
December 8, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27776490/neonatal-bloodstream-infections-in-a-ghanaian-tertiary-hospital-are-the-current-antibiotic-recommendations-adequate
#12
Appiah-Korang Labi, Noah Obeng-Nkrumah, Stephanie Bjerrum, Christabel Enweronu-Laryea, Mercy Jemima Newman
BACKGROUND: Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS: A review of neonatal blood cultures submitted to the microbiology department of the Korle-Bu Teaching Hospital was conducted from January 2010 through December 2013. We assessed the prevalence of bacteria and fungi involved in BSI and the susceptibility coverage of recommended empiric antibiotics by Ghana Standard Treatment guidelines and the WHO recommendations for managing neonatal sepsis...
October 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27721284/the-rising-trend-of-coagulase-negative-staphylococci-in-neonatal-septicemia
#13
Vijaya Shivanna, S R Sunkappa, D Venkatesha
Neonatal septicemia is one of the leading causes of neonatal mortality and morbidity worldwide. Hence, the present study was undertaken to isolate the bacteria causing neonatal sepsis and determine their antibiotic susceptibility pattern. Fifty neonates suspected to have septicemia were screened for 2 months (July and August 2014). Out of 50 specimen, 15 (30%) were blood culture positive. Coagulase-negative staphylococci was the most common isolate (10, 66.6%), with 60% (6 isolates) methicillin resistance. In view of the increasing antibiotic resistance, periodic surveillance should be conducted to control the emergence and spread of antimicrobial resistance...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27633433/characterisation-and-antimicrobial-resistance-of-sepsis-pathogens-in-neonates-born-in-tertiary-care-centres-in-delhi-india-a-cohort-study
#14
(no author information available yet)
BACKGROUND: Sepsis is one of the most common causes of neonatal deaths globally. Most sepsis-related deaths occur in low-income and middle-income countries, where the epidemiology of neonatal sepsis remains poorly understood. Most of these countries lack proper surveillance networks, hampering accurate assessment of the burden of sepsis, implementation of preventive measures, and investment in research. We report results of neonates born in hospital from a multicentre collaboration on neonatal sepsis...
October 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27583393/association-between-birth-route-and-late-onset-sepsis-in-very-preterm-neonates
#15
F Olivier, V Bertelle, P S Shah, C Drolet, B Piedboeuf
OBJECTIVE: To evaluate the association between birth route and late-onset sepsis (LOS), and coagulase-negative Staphylococcal (CONS)-related LOS in preterm neonates. STUDY DESIGN: In this observational study, data from 20,038 infants born between 22 and 32 weeks' gestation and admitted to Canadian neonatal intensive care units between 2010 and 2014 were analyzed retrospectively. The impact of birth route on LOS was assessed using univariate analysis and multiple logistic regression...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27539482/the-impact-of-a-sepsis-quality-improvement-project-on-neurodisability-rates-in-very-low-birthweight-infants
#16
Jonathan W Davis, David Odd, Sally Jary, Karen Luyt
OBJECTIVE: Very low birthweight (VLBW; <1500 g) infants with late-onset sepsis (LOS) have an increased risk of neurodisability. Care bundles to reduce bloodstream infections in neonatal intensive care unit (NICU) are effective in reducing LOS. Our aim was to determine if a sepsis reduction bundle introduced through a quality improvement project would impact neurodevelopmental outcomes in VLBW infants. DESIGN: Cohort study. SETTING: Level 3 regional NICU in the South West of England...
August 18, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27527563/serum-levels-of-vancomycin-is-there-a-prediction-using-doses-in-mg-kg-day-or-m-2-day-for-neonates
#17
Roberta Maia de Castro Romanelli, Lêni Márcia Anchieta, Juliana Chaves Abreu Fernandes, Mariana Antunes Faria Lima, Taís Marina de Souza, Viviane Rosado, Wanessa Trindade Clemente, Paulo Augusto Moreira Camargos
Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m(2)/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013...
September 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27500793/pathogen-and-antimicrobial-resistance-profiles-of-culture-proven-neonatal-sepsis-in-southwest-china-1990-2014
#18
Qi Lu, Min Zhou, Yan Tu, Yao Yao, Jialin Yu, Shupeng Cheng
AIM: Neonatal sepsis (NS) sustains high mortality and morbidity in China, but data on the epidemiology and antimicrobial resistance patterns of NS pathogens are limited. METHODS: The clinical features, aetiology and antimicrobial resistance of culture-proven NS were analysed over a period of 25 years in the metropolitan city of Chongqing in Southwest China. RESULTS: The occurrence rates of neonatal early-onset sepsis (EOS) were found to gradually decrease while late-onset sepsis (LOS) was kept stable from 1990 to 2014...
October 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27472282/clinical-relevance-of-pathogens-detected-by-multiplex-pcr-in-blood-of-very-low-birth-weight-infants-with-suspected-sepsis-multicentre-study-of-the-german-neonatal-network
#19
Birte Tröger, Christoph Härtel, Jan Buer, Michael Dördelmann, Ursula Felderhoff-Müser, Thomas Höhn, Nico Hepping, Georg Hillebrand, Angela Kribs, Janina Marissen, Dirk Olbertz, Peter-Michael Rath, Susanne Schmidtke, Jens Siegel, Egbert Herting, Wolfgang Göpel, Joerg Steinmann, Anja Stein
INTRODUCTION: In the German Neonatal Network (GNN) 10% of very-low-birth weight infants (VLBWI) suffer from blood-culture confirmed sepsis, while 30% of VLBWI develop clinical sepsis. Diagnosis of sepsis is a difficult task leading to potential over-treatment with antibiotics. This study aims to investigate whether the results of blood multiplex-PCR (SeptiFast®) for common sepsis pathogens are relevant for clinical decision making when sepsis is suspected in VLBWI. METHODS: We performed a prospective, multi-centre study within the GNN including 133 VLBWI with 214 episodes of suspected late onset sepsis (LOS)...
2016: PloS One
https://www.readbyqxmd.com/read/27384625/-microbiological-and-therapeutic-characteristics-of-confirmed-neonatal-sepsis-at-a-hospital-in-lima-peru
#20
Giancarlo Alvarado-Gamarra, Katherine M Alcalá-Marcos, Diego M Abarca-Alfaro, Victoria Bao-Castro
OBJECTIVES: To describe the microbiological and therapeutic characteristics of confirmed neonatal sepsis, and determineits incidence and mortality, at the National Hospital Arzobispo Loayza (HNAL) from 2011 to 2012, Lima, Peru. MATERIALS AND METHODS: Retrospective longitudinal study. It was performed a monitoring to newborns with probable sepsis, and assessed the results from positive blood cultures. The newborns' characteristics were obtained from medical records...
March 2016: Revista Peruana de Medicina Experimental y Salud Pública
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