keyword
https://read.qxmd.com/read/38492818/determinants-of-radiological-patterns-and-severity-in-immunocompromised-adults-with-metapneumovirus-infection
#1
JOURNAL ARTICLE
A Al-Hamoud, N Pansu, A-L Brun, N Etienne, E Farfour, V Avettand-Fenoel, C Rouzaud, A Roux, F Suarez, H Salvator, A Serris, E Catherinot, O Lortholary
BACKGROUND: Human Metapneumovirus (HMPV) belongs to the Pneumoviridae family and is responsible for respiratory infections. Mild infections are well-recognized in children, while its precise impact in various categories of immunocompromised adults has not been well addressed. RESEARCH QUESTION: We retrospectively studied HMPV infections in immunocompromised adults followed in two large French university medical centers. STUDY DESIGN AND METHODS: We identified immunocompromised adults with positive HMPV Polymerase Chain Reaction (PCR) for 36 months and reviewed their medical charts...
March 14, 2024: Respiratory Medicine
https://read.qxmd.com/read/38492243/patient-characteristics-associated-with-posttraumatic-stress-symptoms-in-intensive-care-unit-survivors-during-a-one-year-follow-up-a-multicenter-study
#2
JOURNAL ARTICLE
Klara Friberg, Kristin Hofsø, Tone Rustøen, Johan Ræder, Milada Hagen, Kathleen Puntillo, Brita Fosser Olsen
BACKGROUND: Intensive care unit (ICU) patients are at risk of suffering from posttraumatic stress symptoms (PTSS) after ICU survival. OBJECTIVES: To describe the prevalence of high levels of PTSS the first year after ICU admission. Further, to identify specific combinations of patient characteristics (latent classes based on pre-ICU data, demographics, and clinical characteristics), and to investigate possible associations among these classes and PTSS at 3, 6, and 12 months after ICU admission...
March 15, 2024: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/38488667/down-regulating-lncrna-kcnq1ot1-relieves-type-ii-alveolar-epithelial-cell-apoptosis-during-one-lung-ventilation-via-modulating-mir-129-5p-hmgb1-axis-induced-pulmonary-endothelial-glycocalyx
#3
JOURNAL ARTICLE
Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
OBJECTIVE: Endothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one-lung ventilation (OLV)-induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV-induced lung injury and LPS-induced type II alveolar epithelial cell (AECII) apoptosis. METHODS: The rat OLV model was established, and the effects of KCNQ1OT1 on OLV-induced ALI in vivo were explored...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38481465/a-split-lung-ex-vivo-perfusion-model-for-time-and-cost-effective-evaluation-of-therapeutic-interventions-to-the-human-donor-lung
#4
JOURNAL ARTICLE
Nicholas J S Chilvers, Jenny Gilmour, Marnie L Brown, Lucy Bates, Chong Yun Pang, Henning Pauli, John Dark, Andrew J Fisher
With the ongoing shortage of donor lungs, ex vivo lung perfusion (EVLP) offers the opportunity for objective assessment and potential therapeutic repair of marginal organs. There is a need for robust research on EVLP interventions to increase the number of transplantable organs. The use of human lungs, which have been declined for transplant, for these studies is preferable to animal organs and is indeed essential if clinical translation is to be achieved. However, experimental human EVLP is time-consuming and expensive, limiting the rate at which promising interventions can be assessed...
2024: Transplant International
https://read.qxmd.com/read/38475719/placement-of-bronchial-occluder-outside-the-tracheal-tube-in-a-patient-combined-with-airway-compression-undergoing-mediastinal-tumors-resection-a-case-report
#5
JOURNAL ARTICLE
Yihu Zhou, Yueyi Jiang, Yuyan Ding, Lianbing Gu, Jing Tan
BACKGROUND: Mediastinal tumors pose a challenging respiratory and circulatory management during anesthesia procedures, there is a risk of circulatory collapse or complete airway obstruction, which in severe cases can lead to cardiac arrest. We reported a case of anesthetic management using a bronchial blocker placed outside the tracheal tube. In this case report, the patient's trachea was so severely compressed that the airway was extremely narrow, only 4 mm at its narrowest point...
March 12, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38468998/dyselectrolytemia-in-children-with-severe-pneumonia-a-prospective-study
#6
JOURNAL ARTICLE
Vineeta Pande, Renuka Jadhav, Md Ilyaz, Shailaja Mane, Jasleen Dua
Background Pneumonia is a condition characterized by inflammation of the lung parenchyma. It is one of the leading causes of mortality in children below five years of age. While predominantly prevalent in developing countries, it is also associated with significant healthcare-associated costs in developed countries. Among the many risk factors for childhood pneumonia, incomplete immunization, nonexclusive breastfeeding for less than six months, delayed weaning, poor household air quality, malnutrition, and low birth weight are the most commonly found...
February 2024: Curēus
https://read.qxmd.com/read/38457595/laryngeal-mask-airway-combined-with-bronchial-blocker-achieved-1-lung-ventilation-in-a-patient-with-bilateral-vocal-cord-paralysis-a-case-report
#7
JOURNAL ARTICLE
Yi Li, Yudong Zhang, Yu Zhang, Lei Meng, Chong Li, Jianli Li
INTRODUCTION: One-lung ventilation (OLV) is a commonly used technique to facilitate surgical visualization during thoracic surgical procedures. Double-lumen endotracheal tubes and one-lumen tracheal tube combined with bronchial blocker might lead to intubation-related laryngeal injury. PATIENT CONCERNS: In the perioperative period, how to avoid further damage to the vocal cord while achieving OLV during operation is challenging work. DIAGNOSIS: She was diagnosed with systemic lupus erythematosus, bilateral vocal cord paralysis, and lung tumor...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457009/lung-ultrasound-score-predicts-outcomes-in-patients-with-acute-respiratory-failure-secondary-to-covid-19-treated-with-non-invasive-respiratory-support-a-prospective-cohort-study
#8
JOURNAL ARTICLE
Mauro Castro-Sayat, Nicolás Colaianni-Alfonso, Luigi Vetrugno, Gustavo Olaizola, Cristian Benay, Federico Herrera, Yasmine Saá, Guillermo Montiel, Santiago Haedo, Ignacio Previgliano, Ada Toledo, Catalina Siroti
BACKGROUND: Lung ultrasound has demonstrated its usefulness in several respiratory diseases management. One derived score, the Lung Ultrasound (LUS) score, is considered a good outcome predictor in patients with Acute Respiratory Failure (ARF). Nevertheless, it has not been tested in patients undergoing non-invasive respiratory support (NIRS). Taking this into account, the aim of this study is to evaluate LUS score as a predictor of 90-day mortality, ETI (Endotracheal intubation) and HFNC (High Flow Nasal Cannula) failure in patients with ARF due to COVID-19 admitted to a Respiratory Intermediate Care Unit (RICU) for NIRS management...
March 8, 2024: The ultrasound journal
https://read.qxmd.com/read/38448844/effects-of-positive-end-expiratory-pressure-on-regional-cerebral-oxygen-saturation-in-elderly-patients-undergoing-thoracic-surgery-during-one-lung-ventilation-a-randomized-crossover-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Liying Zhao, Shuang Lv, Qian Xiao, Yuan Zhang, Wenbo Yi, Yu Bai, Kangping Lu, Kevin C Bermea, Jessica Semel, Xiaomei Yang, Jianbo Wu
BACKGROUND: A significant reduction in regional cerebral oxygen saturation (rSO2 ) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO2 , pulmonary oxygenation, and hemodynamics during OLV. METHODS: Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH2 O, 5 cmH2 O, and 10 cmH2 O...
March 6, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38433037/re-evaluating-cross-contamination-additional-trials-on-co-ventilation
#10
JOURNAL ARTICLE
Jonathan W McMahon, Donald J Doukas, Christopher Hanuscin, John Quale, Julie Eason, Habtamu Asrat, Mark Silverberg, Lorenzo Paladino
BACKGROUND: Medical equipment can become scarce in disaster scenarios. Prior work has reported that four sheep could be ventilated together on a single ventilator. Others found that this maneuver is possible when needed, but no one has yet investigated whether cross-contamination occurs in co-ventilated individuals. OBJECTIVE: Our goal was to investigate whether an infection could spread between co-ventilated individuals. METHODS: Four 2-L anesthesia bags were connected to a sterilized ventilator circuit that used heat and moisture exchange filters and bacterial and viral filters, as would be expected in this dire scenario...
October 4, 2023: Journal of Emergency Medicine
https://read.qxmd.com/read/38431593/the-impact-of-obesity-on-ventilator-associated-pneumonia-a-us-nationwide-study
#11
JOURNAL ARTICLE
Mohamad El Labban, Michella Abi Zeid Daou, Hiba Smaily, Abbas Hammoud, Ghandi Hassan, Syed Khan, Imad Bou Akl
BACKGROUND: Ventilator-associated pneumonia (VAP) is one of the leading causes of mortality in patients with critical care illness. Since obesity is highly prevalent, we wanted to study its impact on the outcomes of patients who develop VAP. METHODS: Using the National Inpatient Sample (NIS) database from 2017 to 2020, we conducted a retrospective study of adult patients with a principal diagnosis of VAP with a secondary diagnosis with or without obesity according to 10th revision of the International Statistical Classification of Diseases (ICD-10) codes...
March 2, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38423986/sampling-pattern-discrepancy-in-the-application-of-compressed-sensing-hyperpolarized-xenon-129-lung-mri
#12
JOURNAL ARTICLE
Mitra Tavakkoli, Sarah Svenningsen, Yonni Friedlander, Norman B Konyer, Parameswaran Nair, Michael D Noseworthy
Although hyperpolarized (HP) 129 Xe ventilation MRI can be carried out within a breath hold, it is still challenging for many sick patients. Compressed sensing (CS) is a viable alternative to accelerate this approach. However, undersampled images with identical sampling ratios differ from one another. Twenty subjects (n = 10 healthy and n = 10 patients with asthma) were scanned using a GE MR750 3 T scanner, acquiring fully sampled 2D multi-slice HP 129 Xe lung ventilation images (10 s breath hold, 128 × 80 (FE × PE-frequency encoding × phase encoding) and 16 slices)...
February 29, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38422512/respiratory-gating-improves-correlation-between-pulse-wave-transit-time-and-pulmonary-artery-pressure-in-experimental-pulmonary-hypertension
#13
JOURNAL ARTICLE
Fabian Mueller-Graf, Paul Frenkel, Jonas Merz, Susanne Reuter, Brigitte Vollmar, Gerardo Tusman, Sven Pulletz, Stephan Böhm, Amelie Zitzmann, Daniel A Reuter, Andy Adler
Since pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases it was suggested as a potential non-invasive surrogate for PAP. The state of tidal lung filling is also known to affect PWTT independently of PAP. The aim of this retrospective analysis was to test whether respiratory gating improved the correlation coefficient between PWTT and PAP. In each one of five anesthetized and mechanically ventilated pigs two high-fidelity pressure catheters were placed, one directly behind the pulmonary valve, and the second one in a distal branch of the pulmonary artery...
February 29, 2024: Physiological Measurement
https://read.qxmd.com/read/38414172/use-of-an-endobronchial-blocker-in-a-patient-with-tracheobronchial-anomaly-for-minimally-invasive-cardiac-surgery-a-case-report
#14
JOURNAL ARTICLE
Emine Nilgün Zengin, Nevriye Salman, Ayşegül Özgök
Tracheal bronchi (TB) is a rare anomaly and is usually asymptomatic. Although it is generally not a problem when a single lumen tube is used, it may cause ventilation difficulties in the intraoperative period in procedures requiring one lung ventilation, such as minimally invasive cardiac surgery. Therefore, these difficulties may cause intraoperative and postoperative complications. While a double-lumen tube is recommended as the primary choice for one-lung ventilation in patients with TB, bronchial blockers can be used to avoid the need for tube exchange in patients who will remain intubated in the postoperative period...
February 28, 2024: Turkish Journal of Anaesthesiology and Reanimation
https://read.qxmd.com/read/38410536/ve-vco-2-slope-threshold-optimization-for-preoperative-evaluation-in-lung-cancer-surgery-identifying-true-high-and-low-risk-groups
#15
JOURNAL ARTICLE
Karolina Kristenson, Johan Hylander, Miklos Boros, Kristofer Hedman
BACKGROUND: Cardiopulmonary exercise testing (CPET) enables measurement of the slope of the increase in minute ventilation in relation to carbon dioxide elimination during exercise (the VE/VCO2 slope). Several studies have shown that the VE/VCO2 slope is a strong marker for postoperative complications and mortality. However, current thresholds for adverse outcomes are generated from historical data in heart failure patients. METHODS: This was a retrospective analysis of 158 patients with lung cancer who underwent lobectomy or pneumonectomy during 2008-2020...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38407216/prediction-of-bronchopulmonary-dysplasia-by-the-chest-radiographic-thoracic-area-on-day-one-in-infants-with-exomphalos
#16
JOURNAL ARTICLE
Mirna Krishnan, Theodore Dassios, Zoe Bothamley, Saira Haque, Callum Watson, Mark Davenport, Christopher Harris, Anne Greenough
OBJECTIVES: To determine if infants with exomphalos had abnormal antenatal lung growth as indicated by lower chest radiographic thoracic areas (CRTA) on day one compared to controls and whether the CRTA could predict the development of bronchopulmonary dysplasia (BPD). METHODS: Infants with exomphalos cared for between January 2004 and January 2023 were included. The controls were term, newborn infants ventilated for absent respiratory drive at birth, without lung disease and had no supplemental oxygen requirement by 6 h of age...
February 27, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38406334/role-of-simulation-based-training-in-thoracic-anaesthesia
#17
JOURNAL ARTICLE
Swapnil Y Parab, Priya Ranganathan, Madhavi Shetmahajan, Anila Malde
Simulation-based training (SBT) aims to acquire technical and non-technical skills in a simulated fashion without harming the patient. Simulation helps the anaesthesiologist acquire procedural competence and non-technical abilities. In thoracic anaesthesia, various simulators are available with varying degrees of fidelity and costs. Apart from improving bronchoscopy-related skills, other potential applications of SBT include the practice of lung isolation in normal and difficult airway scenarios, troubleshooting complications during surgeries, and certification of the proficiency of anaesthesiologists...
January 2024: Indian Journal of Anaesthesia
https://read.qxmd.com/read/38404046/improved-survival-in-covid-19-related-sepsis-and-ards-treated-with-a-unique-triple-therapy-including-therapeutic-plasma-exchange-a-single-center-retrospective-analysis
#18
JOURNAL ARTICLE
Philip Keith, Rebecca Inez Caldino Bohn, Trung Nguyen, L Keith Scott, Monty Richmond, Matthew Day, Carol Choe, Linda Perkins, Rebecca Burnside, Richard Pyke, Ben Rikard, Amanda Guffey, Arun Saini, H J Park, Joseph Carcillo
BACKGROUND: Throughout the COVID-19 pandemic, the mortality of critically ill patients remained high. Our group developed a treatment regimen targeting sepsis and ARDS which we labeled "triple therapy" consisting of (1) corticosteroids, (2) therapeutic plasma exchange (TPE), and (3) timely intubation with lung protective ventilation. Our propensity analysis assesses the impact of triple therapy on survival in COVID-19 patients with sepsis and ARDS. METHODS: Retrospective propensity analysis comparing triple therapy to no triple therapy in adult critically ill COVID-19 patients admitted to the Intensive Care Unit at Lexington Medical Center from 1 March 2020 through 31 October 2021...
February 2024: Journal of Clinical Apheresis
https://read.qxmd.com/read/38399595/use-of-lung-ultrasound-in-reducing-radiation-exposure-in-neonates-with-respiratory-distress-a-quality-management-project
#19
JOURNAL ARTICLE
Alexandra Floriana Nemes, Adrian Ioan Toma, Vlad Dima, Sorina Crenguta Serboiu, Andreea Ioana Necula, Roxana Stoiciu, Alexandru Ioan Ulmeanu, Andreea Marinescu, Coriolan Ulmeanu
Background and Objectives: Our quality management project aims to decrease by 20% the number of neonates with respiratory distress undergoing chest radiographs as part of their diagnosis and monitoring. Materials and Methods: This quality management project was developed at Life Memorial Hospital, Bucharest, between 2021 and 2023. Overall, 125 patients were included in the study. The project consisted of a training phase, then an implementation phase, and the final results were measured one year after the end of the implementation phase...
February 10, 2024: Medicina
https://read.qxmd.com/read/38394060/tau-and-a%C3%AE-42-in-lavage-fluid-of-pneumonia-patients-are-associated-with-end-organ-dysfunction-a-prospective-exploratory-study
#20
JOURNAL ARTICLE
Phoibe Renema, Jean-Francois Pittet, Angela P Brandon, Sixto M Leal, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T Lin, K Adam Morrow, Jessica Bell, Jonathon P Audia, Diego Alvarez, Troy Stevens, Brant M Wagener
BACKGROUND: Bacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data demonstrate that bacterial pneumonia and sepsis elicit the production of cytotoxic tau and amyloids from pulmonary endothelial cells, which cause lung and brain injury in naïve animal subjects, independent of the primary infection. The contribution of infection-elicited cytotoxic tau and amyloids to end-organ dysfunction has not been examined in the clinical setting...
2024: PloS One
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