keyword
https://read.qxmd.com/read/38536558/a-deep-learning-model-for-translating-ct-to-ventilation-imaging-analysis-of-accuracy-and-impact-on-functional-avoidance-radiotherapy-planning
#1
JOURNAL ARTICLE
Zhen Hou, Youyong Kong, Junxian Wu, Jiabing Gu, Juan Liu, Shanbao Gao, Yicai Yin, Ling Zhang, Yongchao Han, Jian Zhu, Shuangshuang Li
PURPOSE: Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study introduces a novel deep-learning model directly translating planning CT images into CTVI. We investigated the accuracy of generated images and the impact on functional avoidance planning. MATERIALS AND METHODS: Paired planning CT and 4DCT scans from 48 patients with NSCLC were randomized to training (n = 41) and testing (n = 7) data sets...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#2
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38530208/fitness-level-and-sex-related-differences-in-pulmonary-limitations-to-maximal-exercise-in-normoxia-and-hypoxia
#3
JOURNAL ARTICLE
Antoine Raberin, Giorgio Manferdelli, Forrest Schorderet, Nicolas Bourdillon, Grégoire P Millet
PURPOSE: Both maximal-intensity exercise and altitude exposure challenge the pulmonary system that may reach its maximal capacities. Expiratory flow limitation (EFL) and exercise-induced hypoxemia (EIH) are common in endurance-trained athletes. Furthermore, due to their smaller airways and lung size, women, independently of their fitness level, may be more prone to pulmonary limitations during maximal-intensity exercise; particularly when performed in hypoxic conditions. The objective of this study was to investigate the impact of sex and fitness level on pulmonary limitations during maximal exercise in normoxia and their consequences in acute hypoxia...
March 25, 2024: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38528524/respiratory-entrainment-related-reverse-triggering-in-mechanically-ventilated-children
#4
JOURNAL ARTICLE
Robert G T Blokpoel, Ruben B R Brandsema, Alette A Koopman, Jefta van Dijk, Martin C J Kneyber
BACKGROUND: The underlying pathophysiological pathways how reverse triggering is being caused are not fully understood. Respiratory entrainment may be one of these mechanisms, but both terms are used interchangeably. We sought to characterize reverse triggering and the relationship with respiratory entrainment among mechanically ventilated children with and without acute lung injury. METHODS: We performed a secondary phyiology analysis of two previously published data sets of invasively mechanically ventilated children < 18 years with and without lung injury mechanically ventilated in a continuous or intermittent mandatory ventilation mode...
March 25, 2024: Respiratory Research
https://read.qxmd.com/read/38528264/two-lung-ventilation-with-artificial-pneumothorax-on-cerebral-desaturation-and-early-postoperative-cognitive-outcome-a-randomized-controlled-trial
#5
JOURNAL ARTICLE
Lihua Lei, Yanlin Wu, Wencong Chen, Min Chen, Qiaoping Liu, Wenshu Chen, Qun Lin
BACKGROUND: The effect of two lung ventilation (TLV) with carbon dioxide artificial pneumothorax on cerebral desaturation and postoperative neurocognitive changes in elderly patients undergoing elective minimally invasive esophagectomy (MIE) is unclear. OBJECTIVES: The first aim of this study was to compare the effect of TLV and one lung ventilation (OLV) on cerebral desaturation. The second aim was to assess changes in early postoperative cognitive outcomes of two ventilation methods...
March 25, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38523925/surgical-resection-of-a-pneumothorax-in-an-adult-patient-with-a-history-of-wilson-mikity-syndrome-diagnosed-in-childhood
#6
Ryusei Yoshino, Masaki Nakatsubo, Nanami Ujiie, Masahiro Kitada
Wilson-Mikity syndrome (WMS) is a rare condition characterized by various respiratory and pulmonary abnormalities in neonates and infants. However, the diagnosis is based on the findings of physiological tests, such as respiratory function tests. Reports describing the histopathological features of WMS are limited. The patient was a 22-year-old woman with a history of WMS. She had been on a ventilator for the first three months of life due to pulmonary hypertension after early delivery at 24 weeks of gestation and required oxygen therapy until three years of age...
February 2024: Curēus
https://read.qxmd.com/read/38523877/effect-of-dexmedetomidine-on-oxygen-and-intrapulmonary-shunt-qs-qt-during-one-lung-ventilation-in-pediatric-surgery-a-randomized-controlled-trial
#7
JOURNAL ARTICLE
Ayham Khddam, Faten Rostom, Mohammad Y Hajeer
Background One-lung ventilation (OLV) is a common ventilation technique used during thoracic surgery. It can cause serious complications in children, and hypoxic pulmonary vasoconstriction (HPV) is a protective mechanism against the resulting hypoxia. Dexmedetomidine does not affect HPV, so we will investigate its impact on the partial pressure of oxygen in arterial blood (PaO2) and pulmonary shunt fraction (Qs/Qt). Methods Children who underwent OLV were divided into two equal groups. The Dex group received 0...
March 2024: Curēus
https://read.qxmd.com/read/38521944/breath-metabolomics-for-diagnosis-of-acute-respiratory-distress-syndrome
#8
JOURNAL ARTICLE
Shiqi Zhang, Laura A Hagens, Nanon F L Heijnen, Marry R Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J Schultz, Dennis C J J Bergmans, Ronny M Schnabel, Lieuwe D J Bos
BACKGROUND: Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation. AIM: To evaluate the diagnostic accuracy of breath metabolites for ARDS in invasively ventilated intensive care unit (ICU) patients. METHODS: This two-center observational study included critically ill patients receiving invasive ventilation. Gas chromatography and mass spectrometry (GC-MS) was used to quantify the exhaled metabolites...
March 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38515189/investigation-of-the-appropriate-viscosity-of-fibrinogen-in-repairing-pleural-defects-using-ventilation-and-anchoring-in-an-ex-vivo-pig-model
#9
JOURNAL ARTICLE
Akihiro Fukuda, Masaki Hashimoto, Yoshitaka Takegawa, Nobuyuki Kondo, Seiki Hasegawa
OBJECTIVE: Our previous study revealed that the viscosity of fibrinogen could influence the effectiveness of ventilation and anchoring (V/A) methods for controlling air leakages. Here, we examined the association between the viscosity of fibrinogen and effectiveness using an ex vivo pig model. METHODS: The fibrin glue used in this study was BOLHEAL® (KM Biologics Co., Ltd., Kumamoto, Japan). We prepared three types of fibrinogen with different viscosities (higher and lower than normal), including one without additives...
March 21, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38509614/multicentre-randomised-controlled-trial-of-physiological-based-cord-clamping-versus-immediate-cord-clamping-in-infants-with-a-congenital-diaphragmatic-hernia-pinc-statistical-analysis-plan
#10
RANDOMIZED CONTROLLED TRIAL
Emily J J Horn-Oudshoorn, Marijn J Vermeulen, Ronny Knol, Rebekka Bout-Rebel, Arjan B Te Pas, Stuart B Hooper, Suzan C M Cochius-den Otter, Rene M H Wijnen, Kelly J Crossley, Neysan Rafat, Thomas Schaible, Willem P de Boode, Anne Debeer, Berndt Urlesberger, Calum T Roberts, Florian Kipfmueller, Irma Capolupo, Carmen M Burgos, Bettina E Hansen, Irwin K M Reiss, Philip L J DeKoninck
BACKGROUND: Infants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine practice includes immediate clamping of the umbilical cord and endotracheal intubation. Experimental animal studies suggest that clamping the umbilical cord guided by physiological changes and after the lungs have been aerated, named physiological-based cord clamping (PBCC), could enhance the fetal-to-neonatal transition in CDH. We describe the statistical analysis plan for the clinical trial evaluating the effects of PBCC versus immediate cord clamping on pulmonary hypertension in infants with CDH (PinC trial)...
March 20, 2024: Trials
https://read.qxmd.com/read/38505033/veno-venous-extra-corporeal-membrane-oxygenation-in-complex-tracheobronchial-resection
#11
JOURNAL ARTICLE
Luca Voltolini, Alberto Salvicchi, Alessandro Gonfiotti, Sara Borgianni, Giovanni Cianchi, Giovanni Mugnaini, Stefano Bongiolatti
BACKGROUND: Elective extra-corporeal membrane oxygenation (ECMO) is rarely used in thoracic surgery, apart from lung transplantation. The purpose of this study was to summarize our institutional experience with the intraoperative use of veno-venous (VV) ECMO in selected cases of main airway surgery. METHODS: We retrospectively analyzed the data of 10 patients who underwent main airway surgery with the support of VV-ECMO between June 2013 and August 2022. RESULTS: Surgical procedures included: three carinal resection and reconstruction with complete preservation of the lung parenchyma, one right upper double-sleeve lobectomy and hemi-carinal resection, and one sleeve resection of the left main bronchus after previous right lower bilobectomy, for thoracic malignancies; four tracheal/carinal repair for extensive traumatic laceration; one extended tracheal resection due to post-tracheostomy stenosis in a patient who had previously undergone a left pneumonectomy...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505021/the-association-between-patient-preoperative-disposition-and-outcomes-after-diagnostic-lung-biopsy
#12
JOURNAL ARTICLE
Adam R Dyas, Christina M Stuart, Yizhou Fei, Jake L Cotton, Kathryn L Colborn, Michael J Weyant, Simran K Randhawa, Elizabeth A David, John D Mitchell, Christopher D Scott, Robert A Meguid
BACKGROUND: Surgical diagnostic lung biopsy (DLB) is performed to guide the management of pulmonary disease with unclear etiology. However, the utilization of surgical DLB in critically ill patients remains unclear. The purpose of this study was to determine if patient preoperative disposition impacts complication rates after DLB. METHODS: This was retrospective cohort study using electronic health record (EHR) data at one academic institution [2013-2021]. Patients who underwent DLB were identified using current procedural terminology (CPT) codes and cohorted based on preoperative disposition...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38500955/respiratory-function-after-30-years-following-sulfur-mustard-exposure-in-survivors-in-sweden
#13
JOURNAL ARTICLE
Faraidoun Moradi, Sanna Kjellberg, Ying Li, Bledar Daka, Anna-Carin Olin
BACKGROUND: Sulfur mustard (SM) exposure causes acute and chronic respiratory diseases. The extent of small airway dysfunction (SAD) in individuals exposed to SM is unclear. This study evaluated and compared SAD in SM-exposed and SM-unexposed participants using noninvasive lung function tests assessing small airway function. METHODS: This retrospective cohort study involved SM-exposed ( n = 15, mean age: 53 ± 8 years) and SM-unexposed ( n = 15, mean age: 53 ± 7 years) Kurdish-Swedish individuals in Sweden...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38500106/lung-tissue-expression-of-epithelial-injury-markers-is-associated-with-acute-lung-injury-severity-but-does-not-discriminate-sepsis-from-ards
#14
JOURNAL ARTICLE
Natália de Souza Xavier Costa, Giovana da Costa Sigrist, Alexandre Santos Schalch, Luciano Belotti, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage (DAD) is considered its histological hallmark. Sepsis is one of the most common aetiology of ARDS with the highest case-fatality rate. Identifying ARDS patients and differentiate them from other causes of acute respiratory failure remains a challenge. To address this, many studies have focused on identifying biomarkers that can help assess lung epithelial injury...
March 18, 2024: Respiratory Research
https://read.qxmd.com/read/38500033/positive-effects-of-low-dose-s-ketamine-on-preventing-myocardial-injury-after-thoracoscopic-lobectomy-in-patients-aged-70-to-85
#15
JOURNAL ARTICLE
Ziqiang Bi, Lijuan Kong, Jiahui Zhao, Dongdong Song, Fengmei Duan
OBJECTIVE: To investigate the effects of low-dose S-ketamine on marker of myocardial injury (BNP, hs-cTnT and HFABP) after thoracoscopic lobectomy in patients aged 70 to 85. METHODS: One hundred patients (four cases excluded) aged 70-85 years, with body mass index 18-24 kg·m-2 and American Society of Anesthesiologists physical status II-III, scheduled for elective lobectomy from April 2022 to April 2023, were selected. The patients were divided into two groups by a random number table method, namely, the low-dose S-ketamine combined with GDFT group (group S) and the control group (group C), with 48 cases in each group...
March 19, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38496202/forced-expiratory-volume-in-one-second-quotient-fev1q-as-a-prognostic-factor-in-amyotrophic-lateral-sclerosis-patients-comparing-its-predictive-value-to-other-lung-function-measurements
#16
JOURNAL ARTICLE
Carolina da Silva Alves, Tiago Barroso, António Gerardo, Tânia Almeida, Silvia Maduro, José Pedro Boléo-Tomé, Hedi Liberato
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting the first and second motor neurons. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) have conventionally served as indicators of respiratory muscle strength. Recently, FEV1Q (FEV1 divided by the sex-specific first percentile values of absolute FEV1 in adults with lung disease) has been suggested as a predictor of mortality. While FVC has been utilized as a prognostic factor, FEV1Q has not yet been examined...
February 2024: Curēus
https://read.qxmd.com/read/38492818/determinants-of-radiological-patterns-and-severity-in-immunocompromised-adults-with-metapneumovirus-infection
#17
JOURNAL ARTICLE
A Al-Hamoud, N Pansu, A-L Brun, N Etienne, E Farfour, V Avettand-Fenoel, C Rouzaud, A Roux, F Suarez, H Salvator, A Serris, E Catherinot, O Lortholary
BACKGROUND: Human Metapneumovirus (HMPV) belongs to the Pneumoviridae family and is responsible for respiratory infections. Mild infections are well-recognized in children, while its precise impact in various categories of immunocompromised adults has not been well addressed. RESEARCH QUESTION: We retrospectively studied HMPV infections in immunocompromised adults followed in two large French university medical centers. STUDY DESIGN AND METHODS: We identified immunocompromised adults with positive HMPV Polymerase Chain Reaction (PCR) for 36 months and reviewed their medical charts...
March 14, 2024: Respiratory Medicine
https://read.qxmd.com/read/38492243/patient-characteristics-associated-with-posttraumatic-stress-symptoms-in-intensive-care-unit-survivors-during-a-one-year-follow-up-a-multicenter-study
#18
JOURNAL ARTICLE
Klara Friberg, Kristin Hofsø, Tone Rustøen, Johan Ræder, Milada Hagen, Kathleen Puntillo, Brita Fosser Olsen
BACKGROUND: Intensive care unit (ICU) patients are at risk of suffering from posttraumatic stress symptoms (PTSS) after ICU survival. OBJECTIVES: To describe the prevalence of high levels of PTSS the first year after ICU admission. Further, to identify specific combinations of patient characteristics (latent classes based on pre-ICU data, demographics, and clinical characteristics), and to investigate possible associations among these classes and PTSS at 3, 6, and 12 months after ICU admission...
March 15, 2024: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/38488667/down-regulating-lncrna-kcnq1ot1-relieves-type-ii-alveolar-epithelial-cell-apoptosis-during-one-lung-ventilation-via-modulating-mir-129-5p-hmgb1-axis-induced-pulmonary-endothelial-glycocalyx
#19
JOURNAL ARTICLE
Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
OBJECTIVE: Endothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one-lung ventilation (OLV)-induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV-induced lung injury and LPS-induced type II alveolar epithelial cell (AECII) apoptosis. METHODS: The rat OLV model was established, and the effects of KCNQ1OT1 on OLV-induced ALI in vivo were explored...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38481465/a-split-lung-ex-vivo-perfusion-model-for-time-and-cost-effective-evaluation-of-therapeutic-interventions-to-the-human-donor-lung
#20
JOURNAL ARTICLE
Nicholas J S Chilvers, Jenny Gilmour, Marnie L Brown, Lucy Bates, Chong Yun Pang, Henning Pauli, John Dark, Andrew J Fisher
With the ongoing shortage of donor lungs, ex vivo lung perfusion (EVLP) offers the opportunity for objective assessment and potential therapeutic repair of marginal organs. There is a need for robust research on EVLP interventions to increase the number of transplantable organs. The use of human lungs, which have been declined for transplant, for these studies is preferable to animal organs and is indeed essential if clinical translation is to be achieved. However, experimental human EVLP is time-consuming and expensive, limiting the rate at which promising interventions can be assessed...
2024: Transplant International
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