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https://www.readbyqxmd.com/read/29776891/chronic-recurrent-multifocal-osteomyelitis-in-pediatrics-a-diagnostic-challenge
#1
N Roig-Abraham, M Méndez-Hernández, M Martínez-Morillo
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disease that presents with aseptic bone inflammation and can be accompanied by multisystemic symptoms. We present the case of a 14-year-old male with a 2-week history of pain located at the tibial metaphysis and fever. X-ray revealed a lytic lesion in the tibial metaphysis. MRI revealed an intramedullary bone lesion with perilesional bone oedema. CT-guided biopsy discounted malignancy and microbiological cultures were negative. The patient's symptoms and fever worsened after the biopsy; therefore antibiotherapy was commenced for a suspected superinfection...
May 15, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29774559/modeling-effects-of-risk-and-social-distance-on-vaccination-choice
#2
David P Jarmolowicz, Derek D Reed, Alex J Francisco, Jared M Bruce, Shea M Lemley, Amanda S Bruce
Despite vaccines' consistently demonstrated effectiveness, vaccination rates remain suboptimal due to vaccine refusal. Low vaccination rates are particularly problematic for individuals who cannot be vaccinated for medical reasons and thus must rely on herd immunity (i.e., protection of vulnerable individuals due to the high rate of vaccination of other-often socially distant-individuals). The current study uses a novel decision-making task to examine how three variables impacted participants' highest acceptable probability of side effects to their children: 1) the severity of the side effects their children experience, 2) the social distance to the beneficiary of the vaccination, and 3) the probability that the vaccine will prevent disease for that designated beneficiary...
May 17, 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29773969/cost-effectiveness-of-umeclidinium-compared-with-tiotropium-and-glycopyrronium-as-monotherapy-for-chronic-obstructive-pulmonary-disease-a-uk-perspective
#3
Dhvani Shah, Maurice Driessen, Nancy Risebrough, Timothy Baker, Ian Naya, Andrew Briggs, Afisi S Ismaila
Background: Cost-effectiveness of once-daily umeclidinium bromide (UMEC) was compared with once-daily tiotropium (TIO) and once-daily glycopyrronium (GLY) in patients with chronic obstructive pulmonary disease (COPD) from a UK National Health Service (NHS) perspective. Methods: A linked-equation model was implemented to estimate COPD progression, associated healthcare costs, exacerbations rates, life years (LY) and quality-adjusted LY (QALYs). Statistical risk equations for endpoints and resource use were derived from the ECLIPSE and TORCH studies, respectively...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29771574/is-adding-maternal-vaccination-to-prevent-whooping-cough-cost-effective-in-australia
#4
Laure-Anne Van Bellinghen, Alex Dimitroff, Michael Haberl, Xiao Li, Andrew Manton, Karen Moeremans, Nadia Demarteau
Pertussis or whooping cough, a highly infectious respiratory infection, causes significant morbidity and mortality in infants. In adolescents and adults, pertussis presents with atypical symptoms often resulting in under-diagnosis and under-reporting, increasing the risk of transmission to more vulnerable groups. Maternal vaccination against pertussis protects mothers and newborns. This evaluation assessed the cost-effectiveness of adding maternal dTpa (reduced antigen diphtheria, Tetanus, acellular pertussis) vaccination to the 2016 nationally-funded pertussis program (DTPa [Diphtheria, Tetanus, acellular Pertussis] at 2, 4, 6, 18 months, 4 years and dTpa at 12-13 years) in Australia...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29769294/pulmonary-function-tests-as-outcomes-for-systemic-sclerosis-interstitial-lung-disease
#5
REVIEW
Melissa Caron, Sabrina Hoa, Marie Hudson, Kevin Schwartzman, Russell Steele
Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc). We performed a systematic review to characterise the use and validation of pulmonary function tests (PFTs) as surrogate markers for systemic sclerosis-associated interstitial lung disease (SSc-ILD) progression.Five electronic databases were searched to identify all relevant studies. Included studies either used at least one PFT measure as a longitudinal outcome for SSc-ILD progression ( i.e. outcome studies) and/or reported at least one classical measure of validity for the PFTs in SSc-ILD ( i...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29766592/scoring-the-best-deal-quantity-discounts-and-street-price-variation-of-diverted-oxycodone-and-oxymorphone
#6
Jacob A Lebin, David L Murphy, Stevan Geoffrey Severtson, Gabrielle E Bau, Nabarun Dasgupta, Richard C Dart
BACKGROUND: Diverted prescription opioids are significant contributors to drug overdose mortality. Street price has been suggested as an economic metric of the diverted prescription opioid black market. This study examined variables that may influence the street price of diverted oxycodone and oxymorphone. METHODS: A cross-sectional study was conducted utilizing data from the previously validated, crowdsourcing website StreetRx. Street price reports of selected oxycodone and oxymorphone products, between August 22, 2014 and June 30, 2016, were considered for analysis...
May 15, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29766471/self-control-as-measured-by-delay-discounting-is-greater-among-successful-weight-losers-than-controls
#7
Warren K Bickel, Lara N Moody, Mikhail Koffarnus, J Graham Thomas, Rena Wing
Long-term weight loss maintenance is likely to require strong self-control in order to sustain changes in behavior patterns. We, therefore, tested the hypothesis that those who have successfully maintained weight loss may have superior self-control compared to control participants. Self-control was assessed using a delay discounting task through a webbased assessment of members of the National Weight Control Registry (NWCR: N = 757; non-obese = 605; obese = 152) and control participants (Control N = 443; nonobese = 236; obese = 207) from Amazon's Mechanical Turk...
May 15, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29765343/questionnaire-based-maladaptive-decision-coping-patterns-involved-in-binge-eating-among-1013-college-students
#8
Wan-Sen Yan, Ran-Ran Zhang, Yan Lan, Zhi-Ming Li, Yong-Hui Li
Binge Eating Disorder (BED), considered a public health problem because of its impact on psychiatric, physical, and social functioning, merits much attention given its elevation to an independent diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Similar with substance use disorders, some neuropsychological and personality constructs are potentially implicated in the onset and development of BED, in which poor decision-making has been suggested to facilitate overeating and BED...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29765102/the-effects-of-cannabidiol-on-impulsivity-and-memory-during-abstinence-in-cigarette-dependent-smokers
#9
C Hindocha, T P Freeman, M Grabski, H Crudgington, A C Davies, J B Stroud, R K Das, W Lawn, C J A Morgan, H V Curran
Acute nicotine abstinence in cigarette smokers results in deficits in performance on specific cognitive processes, including working memory and impulsivity which are important in relapse. Cannabidiol (CBD), the non-intoxicating cannabinoid found in cannabis, has shown pro-cognitive effects and preliminary evidence has indicated it can reduce the number of cigarettes smoked in dependent smokers. However, the effects of CBD on cognition have never been tested during acute nicotine withdrawal. The present study therefore aimed to investigate if CBD can improve memory and reduce impulsivity during acute tobacco abstinence...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764690/inter-ray-variation-in-metatarsal-strength-properties-in-humans-and-african-apes-implications-for-inferring-bipedal-biomechanics-in-the-olduvai-hominid-8-foot
#10
Biren A Patel, Tea Jashashvili, Stephanie H Bui, Kristian J Carlson, Nicole L Griffin, Ian J Wallace, Caley M Orr, Randall L Susman
When measured as a ratio of mean midshaft diameter to bone length, the OH 8 fossil hominin foot exhibits a metatarsal (Mt) robusticity pattern of 1 > 5 > 3 > 4 > 2, which differs from the widely perceived "common" modern human pattern (1 > 5 > 4 > 3 > 2); African apes generally exhibit a third pattern (1 > 2 > 3 > 4 > 5). Largely because of the relative ranking of Mt2 and Mt5, OH 8 metatarsals structurally resemble the pattern exhibited by bipedal humans more than the pattern of quadrupedal and climbing African apes...
May 12, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29762756/prevalence-antimicrobial-resistance-profile-and-comparison-of-selective-plating-media-for-the-isolation-of-salmonella-spp-in-free-ranging-waterfowl-from-entre-rios-argentina
#11
F I Rodríguez, J M Osinalde, S C Gómez, D G Pulido, M I Caffer, F C Nicolau, D J Bueno
The present study was conducted to estimate the apparent prevalence of Salmonella spp. in free-ranging waterfowl that inhabitant Entre Ríos, Argentina, determine the antimicrobial resistance of the isolated, and compare the performance of two selective plating media used for Salmonella isolation. Five hundred ninety nine free-living waterfowl were sampled one time by cloacal swab from April 2014 to July 2016. Only 6 samples from waterfowl belonged to all counties sampled were positive to Salmonella spp., so the apparent prevalence was 1%...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29760060/corticoinsular-circuits-encode-subjective-value-expectation-and-violation-for-effortful-goal-directed-behavior
#12
Amanda R Arulpragasam, Jessica A Cooper, Makiah R Nuutinen, Michael T Treadway
We are presented with choices each day about how to invest our effort to achieve our goals. Critically, these decisions must frequently be made under conditions of incomplete information, where either the effort required or possible reward to be gained is uncertain. Such choices therefore require the development of potential value estimates to guide effortful goal-directed behavior. To date, however, the neural mechanisms for this expectation process are unknown. Here, we used computational fMRI during an effort-based decision-making task where trial-wise information about effort costs and reward magnitudes was presented separately over time, thereby allowing us to model distinct effort/reward computations as choice-relevant information unfolded...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29757460/evaluating-behavioral-economic-models-of-heavy-drinking-among-college-students
#13
Samuel F Acuff, Kathryn E Soltis, Ashley A Dennhardt, Kristoffer S Berlin, James G Murphy
Heavy drinking among college students is a significant public health concern that can lead to profound social and health consequences, including alcohol use disorder. Behavioral economics posits that low future orientation and high valuation of alcohol (alcohol demand) combined with deficits in alternative reinforcement increase the likelihood of alcohol misuse (Bickel et al., 2011). Despite this, no study has examined the incremental utility of all three variables simultaneously in a comprehensive model METHOD: The current study uses structural equation modeling to test the associations between behavioral economic variables - alcohol demand (latent), future orientation (measured with a delay discounting task and the Consideration of Future Consequences (CFC) scale), and proportionate substance-related reinforcement - and alcohol consumption and problems among 393 heavy drinking college students...
May 14, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29755932/family-food-purchases-of-high-and-low-calorie-foods-in-full-service-supermarkets-and-other-food-retailers-by-black-women-in-an-urban-us-setting
#14
Benjamin W Chrisinger, Katherine Isselmann DiSantis, Amy E Hillier, Shiriki K Kumanyika
Public health interventions to increase supermarket access assume that shopping in supermarkets is associated with healthier food purchases compared to other store types. To test this assumption, we compared purchasing patterns by store-type for certain higher-calorie, less healthy foods (HCF) and lower-calorie, healthier foods (LCF) in a sample of 35 black women household shoppers in Philadelphia, PA. Data analyzed were from 450 food shopping receipts collected by these shoppers over four-week periods in 2012...
June 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29754037/evaluation-of-the-long-term-impact-of-improving-care-for-people-with-type-2-diabetes-in-china
#15
Limin Wang, Qing Ye, Ole Kjerkegaard Nielsen, Anne Gadegaard, William J Valentine, Barnaby Hunt, Linhong Wang
BACKGROUND: The member states of the United Nations launched 17 sustainable development goals (SDGs) as part of the 2030 Sustainable Development Agenda. SDG target 3.4 focused on reducing premature mortality from noncommunicable diseases by one-third by 2030 through prevention and treatment and promoting mental health and well-being. Diabetes is associated with significant clinical and economic burden in China. OBJECTIVES: To examine the impact of improving care for people with diabetes in China, and how this relates to achieving SDG target 3...
May 10, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29753586/cost-effectiveness-of-sensor-augmented-pump-therapy-in-two-different-patient-populations-with-type-1-diabetes-in-italy
#16
A Nicolucci, M C Rossi, D D'Ostilio, A Delbaere, S de Portu, S Roze
BACKGROUND AND AIMS: Sensor-augmented pump therapy (SAP) combines real time continuous glucose monitoring (CGM) with Continuous Subcutaneous Insulin Infusion (CSII) and provides additional benefits beyond those provided by CSII alone. SAP with automated insulin suspension provides early warning of the onset of hyperglycemia and hypoglycemia and has the functionality to suspend insulin delivery if sensor glucose levels are predicted to fall below a predefined threshold. Aim of this study was to assess the cost-effectiveness of SAP with automated insulin suspension versus CSII alone in type 1 diabetes...
April 5, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29752675/estimating-drug-costs-how-do-manufacturer-net-prices-compare-with-other-common-us-price-references
#17
T Joseph Mattingly, Joseph F Levy, Julia F Slejko, Nneka C Onwudiwe, Eleanor M Perfetto
BACKGROUND: Drug costs are frequently estimated in economic analyses using wholesale acquisition cost (WAC), but what is the best approach to develop these estimates? Pharmaceutical manufacturers recently released transparency reports disclosing net price increases after accounting for rebates and other discounts. OBJECTIVE: Our objective was to determine whether manufacturer net prices (MNPs) could approximate the discounted prices observed by the U.S. Department of Veterans Affairs (VA)...
May 12, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29752479/publisher-correction-genome-wide-association-study-of-delay-discounting-in-23-217-adult-research-participants-of-european-ancestry
#18
Sandra Sanchez-Roige, Pierre Fontanillas, Sarah L Elson, Anita Pandit, Ellen M Schmidt, Johanna R Foerster, Gonçalo R Abecasis, Joshua C Gray, Harriet de Wit, Lea K Davis, James MacKillop, Abraham A Palmer
In the version of this article initially published, the consortium authorship was not presented correctly. The 23andMe Research Team was listed as the last author, rather than the fourth, and a line directing readers to the Supplementary Note for a list of members did appear but was not directly associated with the consortium name. Also, the Supplementary Note description stated that both member names and affiliations were included; in fact, only names are given. Finally, the URL for S-PrediXcan was given in the Methods as https://github...
May 11, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29751618/a-cost-benefit-analysis-of-an-active-travel-intervention-with-health-and-carbon-emission-reduction-benefits
#19
Ralph Chapman, Michael Keall, Philippa Howden-Chapman, Mark Grams, Karen Witten, Edward Randal, Alistair Woodward
Active travel (walking and cycling) is beneficial for people’s health and has many co-benefits, such as reducing motor vehicle congestion and pollution in urban areas. There have been few robust evaluations of active travel, and very few studies have valued health and emissions outcomes. The ACTIVE before-and-after quasi-experimental study estimated the net benefits of health and other outcomes from New Zealand’s Model Communities Programme using an empirical analysis comparing two intervention cities with two control cities...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29749040/editors-introduction-miscommunication
#20
Patrick G T Healey, Jan P de Ruiter, Gregory J Mills
Miscommunication is a neglected issue in the cognitive sciences, where it has often been discounted as noise in the system. This special issue argues for the opposite view: Miscommunication is a highly structured and ubiquitous feature of human interaction that systematically underpins people's ability to create and maintain shared languages. Contributions from conversation analysis, computational linguistics, experimental psychology, and formal semantics provide evidence for these claims. They highlight the multi-modal, multi-person character of miscommunication...
April 2018: Topics in Cognitive Science
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