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https://www.readbyqxmd.com/read/29344912/capillary-leak-syndrome-as-a-complication-of-antibody-mediated-rejection-treatment-a-case-report
#1
Juan C Ramirez-Sandoval, Ricardo Varela-Jimenez, Luis E Morales-Buenrostro
We report a case of capillary leak that developed during treatment of antibody-mediated rejection in a kidney transplant recipient. A 53-year-old female transplant recipient experienced an increase in serum creatinine from 1.1 to 1.8 mg/dL. Antibody-mediated rejection was diagnosed by graft biopsy. She was treated with five plasmapheresis sessions (on alternate days with albumin replacement), five doses of immunoglobulin (5 g/dose at 100 mg/kg), a single dose of rituximab (500 mg), and four doses of bortezomib on days 1, 4, 7, and 10 (1...
January 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29344793/the-role-of-bone-secreted-factors-in-burn-induced-muscle-cachexia
#2
REVIEW
Gordon L Klein
PURPOSE OF REVIEW: Burn injury results in resorptive bone loss, failure to make new bone, and muscle protein breakdown resulting in cachexia. The purpose of this review is to examine the relationship between bone loss and muscle atrophy in burn injury with a view to understanding the process at work and how it may apply to other conditions that have similar features. RECENT FINDINGS: We present data suggesting that the use of bisphosphonates in the first 10 days following the burn prevents not only the resorptive bone loss but also the muscle wasting...
January 17, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29341113/prospective-emotion-enables-episodic-prospection-to-shift-time-preference
#3
Shunmin Zhang, Juan Peng, LingLing Qin, Tao Suo, Tingyong Feng
The episodic effect suggests that episodic prospection (imagining future events) can effectively reduce time discounting, the propensity to discount the value of delayed rewards relative to immediate ones. However, less clear is how episodic prospection modulates time preference. As engagement in episodic prospection usually evokes prospective emotions, it was proposed that episodic prospection might work by inducing prospective emotions. Although one previous study has attempted to provide evidence to the emotional account of the episodic effect, shortcomings in its experimental design make its conclusion questionable...
January 16, 2018: British Journal of Psychology
https://www.readbyqxmd.com/read/29338013/dynamical-networks-of-influence-in-small-group-discussions
#4
Mehdi Moussaïd, Alejandro Noriega Campero, Abdullah Almaatouq
In many domains of life, business and management, numerous problems are addressed by small groups of individuals engaged in face-to-face discussions. While research in social psychology has a long history of studying the determinants of small group performances, the internal dynamics that govern a group discussion are not yet well understood. Here, we rely on computational methods based on network analyses and opinion dynamics to describe how individuals influence each other during a group discussion. We consider the situation in which a small group of three individuals engages in a discussion to solve an estimation task...
2018: PloS One
https://www.readbyqxmd.com/read/29337585/narrative-theory-ii-self-generated-and-experimenter-provided-negative-income-shock-narratives-increase-delay-discounting
#5
Alexandra M Mellis, Sarah E Snider, Warren K Bickel
Reading experimenter-provided narratives of negative income shock has been previously demonstrated to increase impulsivity, as measured by discounting of delayed rewards. We hypothesized that writing these narratives would potentiate their effects of negative income shock on decision-making more than simply reading them. In the current study, 193 cigarette-smoking individuals from Amazon Mechanical Turk were assigned to either read an experimenter-provided narrative or self-generate a narrative describing either the negative income shock of job loss or a neutral condition of job transfer...
January 15, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29334549/cost-effectiveness-of-alternative-strategies-for-provision-of-hiv-pre-exposure-prophylaxis-for-people-who-inject-drugs
#6
Rui Fu, Douglas K Owens, Margaret L Brandeau
BACKGROUND: Oral HIV pre-exposure prophylaxis (PrEP) has been recommended as a means of HIV prevention among people who inject drugs (PWID) but, at current prices, is unlikely to be cost-effective for all PWID. OBJECTIVE: To determine the cost-effectiveness of alternative strategies for enrolling PWID in PrEP. DESIGN: Dynamic network model that captures HIV transmission and progression among PWID in a representative US urban center. OUTCOME MEASURES: HIV infections averted, discounted costs and quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29332996/optimal-population-and-exhaustible-resource-constraints
#7
Nicholas Lawson, Dean Spears
A large literature considers the optimal size and growth rate of the human population, trading off the utility value of additional people with the costs of a larger population. In this literature, an important parameter is the social weight placed on population size; a standard result is that a planner with a larger weight on population chooses larger population levels and growth rates. We demonstrate that this result is conditionally overturned when an exhaustible resource constraint is introduced: if the discount rate is small enough, the optimal population today decreases with the welfare weight on population size...
January 2018: Journal of Population Economics
https://www.readbyqxmd.com/read/29331626/implicit-individual-discount-rate-in-china-a-contingent-valuation-study
#8
Hua Wang, Jie He
Two contingent valuation (CV) surveys were conducted in Kunming, China, to estimate households' willingness to pay (WTP) for the Panlong River rehabilitation project. The two surveys were conducted using the same procedures and questionnaires except for the payment schedule arrangements, which permitted a calculation of respondents' implicit discount rate. The surveys provided two estimates of WTP, one with a mean of 23 Yuan in monthly payment over 5 years and the other with a mean of 311 Yuan in a lump-sum payment that will cover all the expenses for a period of 5 years...
January 10, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#9
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29323506/demand-characteristics-in-episodic-future-thinking-delay-discounting-and-healthy-eating
#10
Jillian M Rung, Gregory J Madden
Steep delay discounting, or rapid devaluation of future outcomes, is one mechanism that can account for the chronic selection of smaller-sooner over larger-later outcomes; that is, impulsive choice. Because steep delay discounting is correlated with maladaptive behavior, researchers have explored methods for reducing discounting. One empirically supported method is episodic future thinking (EFT), or vividly imagining one's future before completing the discounting task. However, EFT procedures may include demand characteristics, which could account for some its beneficial effects...
January 11, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29321628/realizing-mitigation-efficiency-of-european-commercial-forests-by-climate-smart-forestry
#11
Rasoul Yousefpour, Andrey Lessa Derci Augustynczik, Christopher P O Reyer, Petra Lasch-Born, Felicitas Suckow, Marc Hanewinkel
European temperate and boreal forests sequester up to 12% of Europe's annual carbon emissions. Forest carbon density can be manipulated through management to maximize its climate mitigation potential, and fast-growing tree species may contribute the most to Climate Smart Forestry (CSF) compared to slow-growing hardwoods. This type of CSF takes into account not only forest resource potentials in sequestering carbon, but also the economic impact of regional forest products and discounts both variables over time...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316514/risk-based-cost-benefit-analysis-for-evaluating-microbial-risk-mitigation-in-a-drinking-water-system
#12
Viktor Bergion, Andreas Lindhe, Ekaterina Sokolova, Lars Rosén
Waterborne outbreaks of gastrointestinal diseases can cause large costs to society. Risk management needs to be holistic and transparent in order to reduce these risks in an effective manner. Microbial risk mitigation measures in a drinking water system were investigated using a novel approach combining probabilistic risk assessment and cost-benefit analysis. Lake Vomb in Sweden was used to exemplify and illustrate the risk-based decision model. Four mitigation alternatives were compared, where the first three alternatives, A1-A3, represented connecting 25, 50 and 75%, respectively, of on-site wastewater treatment systems in the catchment to the municipal wastewater treatment plant...
December 27, 2017: Water Research
https://www.readbyqxmd.com/read/29314035/economic-evaluation-of-floseal-compared-to-nasal-packing-for-the-management-of-anterior-epistaxis
#13
Andre Le, Kednapa Thavorn, Andrea Lasso, Shaun J Kilty
OBJECTIVES/HYPOTHESIS: To evaluate the cost-effectiveness of Floseal, a topically applied hemostatic agent, and nasal packing for the management of epistaxis in Canada. STUDY DESIGN: Outcomes research, a cost-utility analysis. METHODS: We developed a Markov model to compare the costs and health outcomes of Floseal with nasal packing over a lifetime horizon from the perspective of a publicly funded healthcare system. A cycle length of 1 year was used...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29313408/in-honor-of-jurgen-ruesch-remembering-his-work-in-psychiatry
#14
Francisco Balbuena Rivera
BACKGROUND: In a highly technical civilization like ours, in which the interest in human communication transcends academic barriers and clinical practice, it seems necessary to look back to Ruesch's work in psychiatry. The main reason of it rests upon the idea that he was one of the few truly outstanding clinicians, researchers, and theoretical in the field of normal and abnormal communication. In fact, he did not only present a wealth of observational and clinical data; more importantly, he used these data to formulate creative hypotheses about the conflict between man and other human beings...
January 1, 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29310723/iatrogenic-creutzfeldt-jakob-disease-with-amyloid-%C3%AE-pathology-an-international-study
#15
Ignazio Cali, Mark L Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J Collins, Diane Kofskey, Han Wang, Catriona A McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D Belay, Ryan A Maddox, Fabrizio Tagliavini, Maurizio Pocchiari, Ellen Leschek, Brian S Appleby, Jiri G Safar, Lawrence B Schonberger, Pierluigi Gambetti
The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of cadaveric dura mater (DM) grafts.To investigate this phenomenon further, a cohort of 27 iCJD cases - 21 with adequate number of histopathological sections - originating from Australia, France, Italy, and the Unites States, were examined by immunohistochemistry, amyloid staining, and Western blot analysis of the scrapie prion protein (PrPSc), and compared with age-group matched cases of sporadic CJD (sCJD), Alzheimer disease (AD) or free of neurodegenerative diseases (non-ND)...
January 8, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29306836/the-effect-of-hydrocortisone-administration-on-intertemporal-choice
#16
Michala Iben Riis-Vestergaard, Vanessa van Ast, Sandra Cornelisse, Marian Joëls, Johannes Haushofer
Intertemporal choices - decisions involving trade-offs of outcomes at different points in time - are often made under stress. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the release of corticosteroids. Recent studies provide evidence that corticosteroids can induce rapid non-genomic effects focused on immediate resolution of the stressful situation, followed by slower genomic effects focused on long-term recovery after stress. It remains unknown, however, how corticosteroids affect intertemporal choice...
November 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29305628/dissecting-drug-effects-in-preclinical-models-of-impulsive-choice-emphasis-on-glutamatergic-compounds
#17
REVIEW
Justin R Yates
RATIONALE: Impulsive choice is often measured with delay discounting paradigms. Because there are multiple discounting procedures, as well as different statistical analyses that can be applied to data generated from these paradigms, there are some inconsistencies in the literature regarding drug effects on impulsive choice. OBJECTIVES: The goal of the current paper is to review the methodological and analytic approaches used to measure discounting and to discuss how these differences can account for differential drug effects observed across studies...
January 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29303403/i-am-quite-mellow-but-i-wouldn-t-say-everyone-else-is-how-uk-students-compare-their-drinking-behavior-to-their-peers
#18
Emma L Davies, Emma-Ben C Lewis, Sarah E Hennelly
BACKGROUND: Excessive drinking is commonplace at UK Universities. Individuals may misperceive how much they drink compared to others and are less likely to think that they will suffer adverse consequences. Young people often distance themselves and their friends from 'problem drinkers'. OBJECTIVES: The aim of the study was to explore how student drinkers compared their own drinking behaviors to the drinking behaviors of others. METHODS: An online survey was completed by 416 students aged 18-30 (68...
January 5, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29300754/mobile-and-traditional-cognitive-behavioral-therapy-programs-for-generalized-anxiety-disorder-a-cost-effectiveness-analysis
#19
Shefali Kumar, Megan Jones Bell, Jessie L Juusola
BACKGROUND: Generalized anxiety disorder (GAD) is a debilitating mental health illness that affects approximately 3.1% of U.S. adults and can be treated with cognitive behavioral therapy (CBT). With the emergence of digital health technologies, mobile CBT may be a cost-effective way to deliver care. We developed an analysis framework to quantify the cost-effectiveness of internet-based CBT for individuals with GAD. As a case study, we examined the potential value of a new mobile-delivered CBT program for GAD...
2018: PloS One
https://www.readbyqxmd.com/read/29300348/when-veterinarians-support-canine-therapy-bidirectional-benefits-for-clinics-and-therapy-programs
#20
John-Tyler Binfet, Haley J Silas, Sean W Longfellow, Katrina Widmaier-Waurechen
This paper proposes a mutually beneficial model of collaboration between veterinarians and canine therapy programs. Veterinarians and the clinics for whom they work routinely establish collaborations with multiple and varied stakeholders. This might include a laboratory for processing samples and the corresponding courier company needed to deliver samples to the lab or a partnership with a local dog rescue organization for whom discounted rates are offered. One community partnership that stands to benefit both the clinic and the community agency, is for veterinarians to work in tandem with a local canine-assisted therapy program...
January 4, 2018: Veterinary Sciences
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