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Discounting

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https://www.readbyqxmd.com/read/28523480/2-methoxylated-fa-display-unusual-antibacterial-activity-towards-clinical-isolates-of-methicillin-resistant-staphylococcus-aureus-cimrsa-and-escherichia-coli
#1
Néstor M Carballeira, Nashbly Montano, Christian Morales, Joseph Mooney, Xiomara Torres, Dakeishla Díaz, David J Sanabria-Rios
The naturally occurring (6Z)-(±)-2-methoxy-6-hexadecenoic acid (1) and (6Z)-(±)-2-methoxy-6-octadecenoic acid (2) were synthesized in 7-8 steps with 38 and 13% overall yields, respectively, by using an acetylide coupling approach, which made it possible to obtain a 100% cis-stereochemistry for the double bonds. In a similar fashion, the acetylenic analogs (±)-2-methoxy-6-hexadecynoic acid (3) and (±)-2-methoxy-6-octadecynoic acid (4) were also synthesized in 6-7 steps with 48 and 16% overall yields, respectively...
May 18, 2017: Lipids
https://www.readbyqxmd.com/read/28522031/-the-french-medecine-pricing-committee-and-the-medicine-economic-policy-rules-and-competences
#2
D Giorgi
The French medicine pricing committee (CEPS), a governmental and inter-institutional body exercises essential competences for the regulation of the economy of the reimbursable drugs in France. It provides a good example of administered price regulation. It also supervises the proper use of products (control of promotion, conventional control of sales volumes). Finally, it regulates the annual envelope of drug expenditures by means of discounts paid by pharmaceutical companies. The article presents the legal criteria and the doctrine of price setting used in France...
May 15, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28515767/cost-effectiveness-evaluation-of-aspirin-in-primary-prevention-of-myocardial-infarction-amongst-males-with-average-cardiovascular-risk-in-iran
#3
Mohammadreza Amirsadri, Mohammad Javad Sedighi
Aspirin is one of the certified medicines commonly used for the secondary prevention of myocardial infarction (MI). Aspirin side effects and gastrointestinal bleeding, in particular, have arisen debates on its use for the primary prevention of MI. The present research evaluates the cost-effectiveness of the use of aspirin in the primary prevention of MI among Iranian men with average cardiovascular disease (CVD) risk, using Markov modeling technique. The incremental cost-effectiveness ratios (ICERs) estimated to be 864 USA dollars (USD) per quality-adjusted life years (QALY) gained and 782 USD per life years gained (LYG) for each patient in the base-case scenario (public tariffs and no discounting)...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28515183/modeling-lifetime-costs-and-health-outcomes-attributable-to-secondhand-smoke-exposure-at-home-among-korean-adult-women
#4
Jiyae Lee, Ah Ram Han, Dalwoong Choi, Kyung-Min Lim, SeungJin Bae
PURPOSE: The aim of this research is to estimate lifetime costs and health consequences for Korean adult women who were exposed to secondhand smoke (SHS) at home. METHODS: A Markov model was developed to project the lifetime healthcare costs and health outcomes of a hypothetical cohort of Korean women who are 40 years old and were married to current smokers. The Korean epidemiological data were used to reflect the natural history of SHS-exposed and non-exposed women...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28514962/revisiting-annual-screening-for-latent-tuberculosis-infection-in-healthcare-workers-a-cost-effectiveness-analysis
#5
Guillaume A Mullie, Kevin Schwartzman, Alice Zwerling, Dieynaba S N'Diaye
BACKGROUND: In North America, tuberculosis incidence is now very low and risk to healthcare workers has fallen. Indeed, recent cohort data question routine annual tuberculosis screening in this context. We compared the cost-effectiveness of three potential strategies for ongoing screening of North American healthcare workers at risk of exposure. The analysis did not evaluate the cost-effectiveness of screening at hiring, and considered only workers with negative baseline tests. METHODS: A decision analysis model simulated a hypothetical cohort of 1000 workers following negative baseline tests, considering duties, tuberculosis exposure, testing and treatment...
May 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28508382/think-fast-rapid-assessment-of-the-effects-of-episodic-future-thinking-on-delay-discounting-in-overweight-obese-participants
#6
Jeffrey S Stein, Yan Yan Sze, Liqa Athamneh, Mikhail N Koffarnus, Leonard H Epstein, Warren K Bickel
Accumulating laboratory-based evidence indicates that reducing delay discounting (devaluation of delayed outcomes) with the use of episodic future thinking (EFT; mental simulation of future events) improves dietary decision-making and other maladaptive behaviors. Recent work has adapted EFT for use in the natural environment to aid in dietary and weight control by engaging participants in EFT repeatedly throughout the day. These efforts may benefit from minimizing the amount of time required for measurement and implementation of EFT...
May 15, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28507654/cost-effectiveness-of-pharmacist-care-for-managing-hypertension-in-canada
#7
Carlo Marra, Karissa Johnston, Valerie Santschi, Ross T Tsuyuki
BACKGROUND: More than half of all heart disease and stroke are attributable to hypertension, which is associated with approximately 10% of direct medical costs globally. Clinical trial evidence has demonstrated that the benefits of pharmacist intervention, including education, consultation and/or prescribing, can help to reduce blood pressure; a recent Canadian trial found an 18.3 mmHg reduction in systolic blood pressure associated with pharmacist care and prescribing. The objective of this study was to evaluate the economic impact of such an intervention in a Canadian setting...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28506225/healthrecsys-a-semantic-content-based-recommender-system-to-complement-health-videos
#8
Carlos Luis Sanchez Bocanegra, Jose Luis Sevillano Ramos, Carlos Rizo, Anton Civit, Luis Fernandez-Luque
BACKGROUND: The Internet, and its popularity, continues to grow at an unprecedented pace. Watching videos online is very popular; it is estimated that 500 h of video are uploaded onto YouTube, a video-sharing service, every minute and that, by 2019, video formats will comprise more than 80% of Internet traffic. Health-related videos are very popular on YouTube, but their quality is always a matter of concern. One approach to enhancing the quality of online videos is to provide additional educational health content, such as websites, to support health consumers...
May 15, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28502850/cost-effectiveness-of-a-bronchial-genomic-classifier-for-the-diagnostic-evaluation-of-lung-cancer
#9
David Feller-Kopman, Shan Liu, Benjamin P Geisler, Malcolm M DeCamp, Jan B Pietzsch
BACKGROUND: The use of a bronchial genomic classifier has been shown to improve the diagnostic accuracy of bronchoscopy for suspected lung cancer by identifying patients who may be more suitable for radiographic surveillance as opposed to undergoing invasive procedures. Our objective was to assess the cost-effectiveness of bronchoscopy plus genomic classifier versus bronchoscopy alone in the diagnostic work-up of patients at intermediate risk for lung cancer. METHODS: A decision-analytic Markov model was developed to project the costs and effects of two competing strategies, using test performance from the AEGIS-1 and AEGIS-2 studies...
May 9, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28502579/point-of-sale-cigarette-purchase-patterns-among-u-s-adult-smokers-national-adult-tobacco-survey-2012-2014
#10
Judy Kruger, Amal Jama, Joseph G L Lee, Sara Kennedy, Asha Banks, Saida Sharapova, Israel Agaku
Tobacco products are ubiquitous in most U.S. retail environments. Given that data on preferred point-of-sale purchase locations among U.S. adult tobacco users are limited, an enhanced understanding of tobacco purchase locations can help inform tobacco control policy, planning, and practice. We investigated prevalence and sociodemographic characteristics associated with cigarette purchase location among U.S. adult smokers. Pooled data came from the 2012-2013 (N=60,192) and 2013-2014 (N=75,233) National Adult Tobacco Surveys...
May 11, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28501421/-what-time-is-my-next-meal-delay-discounting-individuals-choose-smaller-portions-under-conditions-of-uncertainty
#11
Annie R Zimmerman, Danielle Ferriday, Sarah R Davies, Ashley A Martin, Peter J Rogers, Alice Mason, Jeffrey M Brunstrom
'Dietary' delay discounting is typically framed as a trade-off between immediate rewards and long-term health concerns. Our contention is that prospective thinking also occurs over shorter periods, and is engaged to select portion sizes based on the interval between meals (inter-meal interval; IMI). We sought to assess the extent to which the length of an IMI influences portion-size selection. We predicted that delay discounters would show 'IMI insensitivity' (relative lack of concern about hunger or fullness between meals)...
May 10, 2017: Appetite
https://www.readbyqxmd.com/read/28500504/delay-discounting-and-parental-monitoring-in-adolescents-with-poorly-controlled-type-1-diabetes
#12
Amy Hughes Lansing, Catherine Stanger, Rebecca Crochiere, Ann Carracher, Alan Budney
In a sample of adolescents with poorly controlled type 1 diabetes, this study examined if delay discounting, the extent to which individuals prefer immediate over delayed rewards, was associated with severity of non-adherence and poor glycemic control, and if parental monitoring of diabetes management moderated those associations. Sixty-one adolescents (M age = 15.08 years, SD 1.43) with poorly controlled type 1 diabetes completed a delayed discounting task and an HbA1c blood test. Adherence was assessed via self-monitoring of blood glucose (SMBG) data from adolescents' glucometers...
May 12, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28500481/pathways-linking-adverse-childhood-experiences-to-cigarette-smoking-among-young-black-men-a-prospective-analysis-of-the-role-of-sleep-problems-and-delayed-reward-discounting
#13
Assaf Oshri, Steven Kogan, Sihong Liu, Lawrence Sweet, James Mackillop
BACKGROUND: African American men experience increases in smoking during the young adult transition. Exposure to childhood adversity, a risk factor which disproportionately affects African American men, has been identified as a robust precursor to health risk behavior in general and cigarette smoking in particular. The intermediate mechanisms that transmit the influence of early adversity to smoking behavior are not well understood. PURPOSE: We tested a model of the escalation of smoking behaviors among young adult African American men, investigating sleep disturbance and delayed reward discounting as intermediate factors linking adverse childhood experiences with smoking...
May 12, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28499887/what-is-the-impact-on-the-healthcare-system-if-access-to-bariatric-surgery-is-delayed
#14
Ricardo V Cohen, Alexandre Luque, Silvio Junqueira, Rodrigo Antonini Ribeiro, Carel W Le Roux
BACKGROUND: Bariatric surgery has been available as part of the Brazilian Public Health System for patients with body mass index>40 kg/m(2) (or>35 kg/m(2) with co-morbidities) since 1999. However, access to surgery is challenging, with eligible patients waiting up to 7 years before surgery. OBJECTIVE: Our objective was to compare costs and effectiveness of different waiting times before surgery versus prompt surgery. SETTINGS: Public practice...
March 31, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28498515/brain-structure-linking-delay-discounting-and-academic-performance
#15
Song Wang, Feng Kong, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Qiyong Gong
As a component of self-discipline, delay discounting refers to the ability to wait longer for preferred rewards and plays a pivotal role in shaping students' academic performance. However, the neural basis of the association between delay discounting and academic performance remains largely unknown. Here, we examined the neuroanatomical substrates underlying delay discounting and academic performance in 214 adolescents via voxel-based morphometry (VBM) by performing structural magnetic resonance imaging (S-MRI)...
May 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28494412/long-term-reliability-and-stability-of-behavioral-measures-among-adolescents-the-delay-discounting-and-stroop-tasks
#16
Víctor Martínez-Loredo, José Ramón Fernández-Hermida, José Luis Carballo, Sergio Fernández-Artamendi
Delay Discounting (DD) and the Stroop test are two fundamental tasks for the assessment of impulsivity and inhibitory control, core features of several behavioral disorders. Although the study of reliability and temporal stability is important, only studies with adults and small samples have been carried out. The aim of this study is to assess the one-year reliability and temporal stability of both tasks among adolescents. A total of 1375 adolescents (M = 13.08 years old, SD = 0.51) made up the final sample (53...
May 8, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28494225/what-about-me-the-loss-of-self-through-the-experience-of-traumatic-childbirth
#17
Veronica Byrne, Jonathan Egan, Pádraig Mac Neela, Kiran Sarma
BACKGROUND AND OBJECTIVE: birth trauma has become an increasingly recognised maternal mental health issue and has important implications for both mother and infant. The importance of subjective birth experience in the development of birth trauma has been identified and may mediate the lack of theoretical consistency in this area. The current study aims to explore the subjective experience of birth trauma among first time mothers in Ireland. It aims to separate the potential effects of peripartum depression (PPD) from this in limiting this qualitative investigation to women who reported birth trauma, without PPD...
May 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28493993/mechanism-of-down-regulation-of-na-h-exchanger-2-in-experimental-colitis
#18
Amal Ali Soleiman, Farook Thameem, Islam Khan
BACKGROUND: The Na-H exchanger [NHE] performs an electroneutral uptake of NaCl and water from the lumen of the gastrointestinal tract. There are several distinct NHE isoforms, some of which show an altered expression in the inflammatory bowel diseases (IBD). In this study, we examined a role of NHE-2 in experimental colitis. METHODS: Colitis was induced in male Sprague-Dawley rats by intra-rectal administration of trinitrobenzenesulphonic acid (TNBS). On day 6 post-TNBS, the animals were sacrificed, colonic and ileal segments were taken out, cleaned with phosphate buffered saline and used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28487067/selective-and-interactive-effects-of-d2-receptor-antagonism-and-positive-allosteric-mglur4-modulation-on-waiting-impulsivity
#19
Sarah N Isherwood, Trevor W Robbins, Janet R Nicholson, Jeffrey W Dalley, Anton Pekcec
BACKGROUND: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D2 receptor antagonist eticlopride, on two distinct forms of impulsivity...
May 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28486708/withdrawal-related-changes-in-delay-discounting-predict-short-term-smoking-abstinence
#20
Rickie Miglin, Joseph W Kable, Maureen E Bowers, Rebecca L Ashare
Introduction: Impulsive decision making is associated with smoking behavior and reflects preferences for smaller, immediate rewards and intolerance of temporal delays. Nicotine withdrawal may alter impulsive decision making and time perception. However, little is known about whether withdrawal-related changes in decision making and time perception predict smoking relapse. Methods: Forty-five smokers (14 female) completed two laboratory sessions, one following 24-hour abstinence and one smoking-as-usual (order counterbalanced; biochemically verified abstinence)...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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