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https://www.readbyqxmd.com/read/29764123/the-folding-pathways-and-thermodynamics-of-semiflexible-polymers
#1
Jing Wu, Chenqian Cheng, Gaoyuan Liu, Ping Zhang, Tao Chen
Inspired by the protein folding and DNA packing, we have systematically studied the thermodynamic and kinetic behaviors of single semiflexible homopolymers by Langevin dynamics simulations. In line with experiments, a rich variety of folding products, such as rod-like bundles, hairpins, toroids, and a mixture of them, are observed in the complete diagram of states. Moreover, knotted structures with a significant population are found in a certain range of bending stiffness in thermal equilibrium. As the solvent quality becomes poorer, the population of the intermediate occurring in the folding process increases, which leads to a severe chevron rollover for the folding arm...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29759788/novel-extravascular-defibrillation-configuration-with-a-coil-in-the-substernal-space-the-asd-clinical-study
#2
Joseph Y S Chan, Jacek Lelakowski, Francis D Murgatroyd, Lucas V Boersma, Jian Cao, Vladimir Nikolski, Griet Wouters, Mark C S Hall
OBJECTIVES: This study assessed the defibrillation efficacy of the substernal-lateral electrode configuration. BACKGROUND: Subcutaneous implantable cardioverter-defibrillators (ICDs) are regarded as alternatives to transvenous ICDs in certain subjects. However, substantially higher shock energy of up to 80 J may be required. Proposed is a new defibrillation method of placing the shock coil into the substernal space. METHODS: This prospective, nonrandomized, feasibility study was conducted in subjects scheduled for midline sternotomy or implant of ICD...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759436/single-and-dual-coil-defibrillator-leads-the-electrophysiology-social-network-in-action
#3
EDITORIAL
Fred Kusumoto
No abstract text is available yet for this article.
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759435/temporal-trends-in-and-factors-associated-with-use-of-single-versus-dual-coil-implantable-cardioverter-defibrillator-leads-data-from-the-ncdr-icd-registry
#4
Sean D Pokorney, Craig S Parzynski, James P Daubert, Donald D Hegland, Paul D Varosy, Jeptha P Curtis, Sana M Al-Khatib
OBJECTIVES: This analysis evaluated temporal trends and factors associated with the use of dual-coil implantable cardioverter-defibrillator (ICD) leads. BACKGROUND: Data suggest that dual-coil ICD leads are not associated with lower mortality and can be more difficult to extract than single-coil leads. METHODS: A total of 435,772 patients at 1,690 hospitals underwent ICD lead insertion in the National Cardiovascular Data Registry's ICD Registry between April 2010 and December 2015...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29749066/direct-nano-spectroscopic-verification-of-the-amyloid-aggregation-pathway
#5
Ewelina Lipiec, David Perez-Guaita, Janina Kaderli, Bayden Wood, Renato Zenobi
The aggregation pathways of neurodegenerative peptides determine the disease etiology and their better understanding can lead to strategies for early disease treatment. Previous research has allowed modelling of hypothetic aggregation pathways. However, their direct experimental observation has been elusive due to methodological limitations. Here we demonstrate that nanoscale chemical mapping by Tip-Enhanced Raman Spectroscopy of single amyloid fibrils at various stages of aggregation captures the fibril formation process...
May 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29736426/stent-assisted-treatment-of-ruptured-intracranial-aneurysms-in-the-acute-phase-a-single-center-experience
#6
Michael J Ho, Sophia L Göricke, Petra Mummel, Christoph Mönninghoff, Karsten Wrede, Isabel Wanke
Introduction: The purpose of this study was to analyze the results of patients with ruptured aneurysms who were treated with a specific microstent in the acute phase of subarachnoid hemorrhage. Methods: Data from patients with acutely-ruptured intracranial aneurysm treated with the Neuroform stent in the period between 2003 and 2016 were retrospectively assessed, addressing aneurysm occlusion and clinical outcome with a focus on periprocedural complications. Results: Twenty-nine consecutive patients with ruptured intracranial aneurysms were included in the analysis...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29670177/proton-decoupled-carbon-magnetic-resonance-spectroscopy-in-human-calf-muscles-at-7-t-using-a-multi-channel-radiofrequency-coil
#7
Sigrun Goluch, Roberta Frass-Kriegl, Martin Meyerspeer, Michael Pichler, Jürgen Sieg, Martin Gajdošík, Martin Krššák, Elmar Laistler
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29596906/atrial-electrogram-quality-in-single-pass-defibrillator-leads-with-floating-atrial-bipole-in-patients-with-permanent-atrial-fibrillation-and-cardiac-resynchronization-therapy
#8
Christian Sticherling, Dirk Müller, Beat A Schaer, Silke Krüger, Christof Kolb
Many patients receiving cardiac resynchronization therapy (CRT) suffer from permanent atrial fibrillation (AF). Knowledge of the atrial rhythm is important to direct pharmacological or interventional treatment as well as maintaining AV-synchronous biventricular pacing if sinus rhythm can be restored. A single pass single-coil defibrillator lead with a floating atrial bipole has been shown to obtain reliable information about the atrial rhythm but has never been employed in a CRT-system. The purpose of this study was to assess the feasibility of implanting a single coil right ventricular ICD lead with a floating atrial bipole and the signal quality of atrial electrograms (AEGM) in CRT-defibrillator recipients with permanent AF...
March 26, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29572716/comparison-of-single-coil-lead-versus-dual-coil-lead-of-implantable-cardioverter-defibrillator-on-lead-related-venous-complications-in-a-canine-model
#9
Ziqing Yu, Yuan Wu, Shengmei Qin, Jingfeng Wang, Xueying Chen, Ruizhen Chen, Yangang Su, Junbo Ge
PURPOSE: Dual- coil lead (DCL) of implantable cardioverter defibrillator (ICD) is preferred clinically in patients. However, it is related to higher risk of venous stenosis and thrombosis. The present study was done to compare the fibrosis and extraction of the leads between the single-coil lead (SCL) and DCL in animal models. METHODS: This was a chronic animal study with a follow-up duration of 6 months. Twenty mongrel dogs were randomly divided into DCL group or SCL group...
March 23, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29504190/advancing-transcranial-magnetic-stimulation-methods-for-complex-regional-pain-syndrome-an-open-label-study-of-paired-theta-burst-and-high-frequency-stimulation
#10
Mark Gaertner, Jiang-Ti Kong, Kristen H Scherrer, Alyssa Foote, Sean Mackey, Kevin A Johnson
INTRODUCTION: Complex Regional Pain Syndrome (CRPS), a rare and severe chronic pain condition, often responds poorly to existing treatments. Previous studies demonstrated Transcranial Magnetic Stimulation (TMS) provided short-term pain relief for upper extremity CRPS. METHODS: Building on previous methodologies, we employed a TMS protocol that may lead to significant pain relief for upper and lower extremity CRPS in a nonrandomized open label pilot trial involving 21 participants...
March 4, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29483506/a-dual-mechanism-promotes-switching-of-the-stormorken-stim1-r304w-mutant-into-the-activated-state
#11
Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, Christoph Romanin
STIM1 and Orai1 are key components of the Ca2+ -release activated Ca2+ (CRAC) current. Orai1, which represents the subunit forming the CRAC channel complex, is activated by the ER resident Ca2+ sensor STIM1. The genetically inherited Stormorken syndrome disease has been associated with the STIM1 single point R304W mutant. The resulting constitutive activation of Orai1 mainly involves the CRAC-activating domain CAD/SOAR of STIM1, the exposure of which is regulated by the molecular interplay between three cytosolic STIM1 coiled-coil (CC) domains...
February 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29465821/quantitative-magnetic-resonance-spectroscopy-at-3t-based-on-the-principle-of-reciprocity
#12
Niklaus Zoelch, Andreas Hock, Anke Henning
Quantification of magnetic resonance spectroscopy signals using the phantom replacement method requires an adequate correction of differences between the acquisition of the reference signal in the phantom and the measurement in vivo. Applying the principle of reciprocity, sensitivity differences can be corrected at low field strength by measuring the RF transmitter gain needed to obtain a certain flip angle in the measured volume. However, at higher field strength the transmit sensitivity may vary from the reception sensitivity, which leads to wrongly estimated concentrations...
May 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29453324/incidence-and-predictors-of-perioperative-complications-with-transvenous-lead-extractions-real-world-experience-with-national-cardiovascular-data-registry
#13
Nitesh Sood, David T Martin, Rachel Lampert, Jeptha P Curtis, Craig Parzynski, Jude Clancy
BACKGROUND: Transvenous lead extraction is an integral part of management of patients with cardiovascular implantable electronic devices. Real-world incidence and predictors of perioperative complications in extractions involving implantable cardioverter-defibrillator leads have not been described in detail. METHODS AND RESULTS: Data from the National Cardiovascular Data Registry Implantable Cardioverter-Defibrillator Registry were analyzed. Lead extraction was defined as removal of leads implanted for >1 year...
February 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29428142/should-single-coil-implantable-cardioverter-defibrillator-leads-be-used-in-all-patients
#14
REVIEW
Fahad Almehmadi, Jaimie Manlucu
The historical preference for dual-coil implantable cardioverter defibrillator leads stems from high defibrillation thresholds associated with old device platforms. The high safety margins generated by contemporary devices have rendered the modest difference in defibrillation efficacy between single- and dual-coil leads clinically insignificant. Cohort data demonstrating worse lead extraction outcomes and higher all-cause mortality have brought the incremental utility of an superior vena cava coil into question...
March 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29423476/knots-modify-the-coil-stretch-transition-in-linear-dna-polymers
#15
Beatrice W Soh, Vivek Narsimhan, Alexander R Klotz, Patrick S Doyle
We perform single-molecule DNA experiments to investigate the relaxation dynamics of knotted polymers and examine the steady-state behavior of knotted polymers in elongational fields. The occurrence of a knot reduces the relaxation time of a molecule and leads to a shift in the molecule's coil-stretch transition to larger strain rates. We measure chain extension and extension fluctuations as a function of strain rate for unknotted and knotted molecules. The curves for knotted molecules can be collapsed onto the unknotted curves by defining an effective Weissenberg number based on the measured knotted relaxation time in the low extension regime, or a relaxation time based on Rouse/Zimm scaling theories in the high extension regime...
February 28, 2018: Soft Matter
https://www.readbyqxmd.com/read/29227914/design-and-use-of-a-folded-four-ring-double-tuned-birdcage-coil-for-rat-brain-sodium-imaging-at-9-4-t
#16
YongHyun Ha, Chang-Hoon Choi, Wieland A Worthoff, Aliaksandra Shymanskaya, Michael Schöneck, Antje Willuweit, Jörg Felder, N Jon Shah
A folded four-ring quadrature birdcage coil was designed and constructed with a double-tune configuration of an outer high-pass coil for1 H (400 MHz) and inner low-pass coil for23 Na (105.72 MHz at 9.4 T). The coil was evaluated on the bench and in the scanner, comparing its performance with that of single-tuned coils and a large four-ring coil. All coils were tuned and matched and the isolation between two quadrature ports was found to be better than -13.7 dB for1 H and -27 dB for23 Na. Signal-to-noise ratios (SNRs) were calculated and23 Na flip angle maps were acquired...
January 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29218341/templated-co-assembly-into-nanorods-of-polyanions-and-artificial-virus-capsid-proteins
#17
A Hernandez-Garcia, M A Cohen Stuart, R de Vries
Recombinant triblock polypeptides C-Sn -B, where C is a 400 amino acid long hydrophilic random coil block, Sn is a multimer of the silk-like octapeptide S = (GAGAGAGQ), and B = K12 is an oligolysine, have previously been shown to encapsulate double stranded DNA into rod-shaped, virus-like particles. In order to gain insight of the co-assembly process, and in order to be able to use these proteins for templating other types of nanorods, we here explore their co-assembly with a range of polyanionic templates: poly(acrylic acids) (PAA) of a wide range of lengths, poly(styrene sulphonate) (PSS) and the stiff anionic polysaccharide xanthan...
December 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/29215564/piezoelectric-potential-in-single-crystalline-zno-nanohelices-based-on-finite-element-analysis
#18
Huimin Hao, Kory Jenkins, Xiaowen Huang, Yiqian Xu, Jiahai Huang, Rusen Yang
Electric potential produced in deformed piezoelectric nanostructures is of significance for both fundamental study and practical applications. To reveal the piezoelectric property of ZnO nanohelices, the piezoelectric potential in single-crystal nanohelices was simulated by finite element method calculations. For a nanohelix with a length of 1200 nm, a mean coil radius of 150 nm, five active coils, and a hexagonal coiled wire with a side length 100 nm, a compressing force of 100 nN results in a potential of 1...
December 7, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29131633/effect-of-the-helix-coil-transition-in-bovine-skin-gelatin-on-its-associative-phase-separation-with-lysozyme
#19
Yurij A Antonov, Irina Zhuravleva, Alexander Volodine, Paula Moldenaers, Ruth Cardinaels
It is known that the formation of electrostatic polyelectrolyte complexes can induce conformational changes in the interacting macromolecules. However, the opposite effect, namely, that of the helix-coil transition of one of the interacting polyelectrolytes on its associative phase separation with another polyelectrolyte and the possible phase transitions in such systems, has not been determined. Atomic force and confocal laser scanning microscopy, phase analysis, dynamic and electrophoretic light scattering, turbidimetry, absorption, and fluorescence measurements as well as differential scanning calorimetry and rheology were used to study the effect of the helix-coil transition in bovine skin gelatin (Gel) on its associative phase separation with hen egg white lysozyme (Lys) at different temperatures (18-40 °C) and various Lys/Gel weight ratios (0...
November 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29107755/interaction-between-shock-coils-increased-the-incidence-of-inappropriate-therapies-and-lead-failure-in-implantable-cardioverter-defibrillator
#20
Mohammad El Garhy, Marc-Alexander Ohlow, Bernward Lauer
AIMS: Shock coil interaction in patients with multiple implantable cardioverter defibrillator (ICD) leads is occasionally observed. We aimed to evaluate the incidence of shock coil interaction and its clinical relevance. METHODS AND RESULTS: All ICD patients (646 patients) who came to follow up control in our ICD ambulance between January 1, 2011, and December 31, 2011 in the department of cardiology in Bad Berka hospital were retrospectively evaluated in this study...
January 2018: Indian Pacing and Electrophysiology Journal
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