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https://www.readbyqxmd.com/read/28231388/structural-characterization-and-antifatigue-effect-in-vivo-of-maca-lepidium-meyenii-walp-polysaccharide
#1
Weimin Tang, Lu Jin, Lianghua Xie, Juqing Huang, Nan Wang, Bingquan Chu, Xulin Dai, Yu Liu, Rui Wang, Ying Zhang
Maca (Lepidium meyenii Walp) polysaccharides (MP) with purity of 99.2% were obtained to investigate their structural characteristics and antifatigue effect in vivo. The physicochemical properties of MP were analyzed through high-performance gel filtration chromatography, IR, monosaccharide composition, methylation, GC-MS, and NMR analyses. The antifatigue effect of MP was evaluated by using a mouse weight-loaded swimming model. MP is an acidic heteropolysaccharide with an average molecular weight (Mw ) of 793...
February 23, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28231066/valuing-environmental-health-for-informed-policy-making
#2
Vojtěch Máca, Jan Melichar, Milan Ščasný, Markéta Braun Kohlová
BACKGROUND: Monetized environmental health impact assessments help to better evaluate the environmental burden of a wide range of economic activities. Apart from the limitations and uncertainties in physical and biological science used in such assessments, assumptions taken from economic valuation may also substantially influence subsequent policy-making considerations. AIM: This study attempts to demonstrate the impact of normative policy assumptions on quantified external costs using a case study of recently discussed variants of future coal mining and use of extracted coal in electricity and heat generation in the Czech Republic...
February 23, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28212012/-meyeniins-a-c-novel-hexahydroimidazo-1-5-c-thiazole-derivatives-from-the-tubers-of-lepidium-meyenii-complete-structural-elucidation-by-biomimetic-synthesis-and-racemic-crystallization
#3
Min Zhou, Hang-Ying Ma, Zhi-Hua Liu, Guang-Yu Yang, Gang Du, Yan-Qing Ye, Gan-Peng Li, Qiu-Fen Hu
(+)-Meyeniins A-C (1-3), a novel class of sulfur-containing hexahydroimidazo[1,5-c]thiazole derivatives, were isolated from the tubers of Lepidium meyenii (maca) cultivated in Lijiang, Yunnan province, China. Guided by their biosynthetic hypothesis, a stereocontrolled biomimetic synthesis of meyeniins A-C and their individual enantiomers was efficiently accomplished by a combination of a condensation reaction and Edman degradation. The formation of high-quality crystals for X-ray crystallography occurred much more readily from a racemic mixture of (±)-meyeniin A than with the single enantiomer alone in this case...
February 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28174084/protective-effect-of-polysaccharide-from-maca-lepidium-meyenii-on-hep-g2-cells-and-alcoholic-liver-oxidative-injury-in-mice
#4
Lijun Zhang, Qingsheng Zhao, Liwei Wang, Mingxia Zhao, Bing Zhao
To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%. In order to assess the antioxidant activities of MP-1, four kinds of methods were used, including scavenging hydroxyl radical, DPPH, superoxide anion radical, and FRAP, and the results indicated high antioxidant activities. Furthermore, hepatoprotective activity of MP-1 was studied both in vitro and vivo...
February 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28117590/structural-characterization-of-a-novel-polysaccharide-from-lepidium-meyenii-maca-and-analysis-of-its-regulatory-function-in-macrophage-polarization-in-vitro
#5
Mengmeng Zhang, Wenjia Wu, Yao Ren, Xiaofeng Li, Yuqian Tang, Tian Min, Furao Lai, Hui Wu
In our previous study, three novel polysaccharides, named MC-1, MC-2, and MC-3, were separated from the roots of maca (Lepidium meyenii), which is a food source from the Andes region. The structural information and immunomodulatory activity of MC-1 were then investigated. The structure and activity of MC-2 are still unknown. In this study, structural characterization revealed that MC-2 has an average molecular weight of 9.83 kDa and is composed of arabinose (20.9%), mannose (4.5%), glucose (71.9%), and galactose (2...
February 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28078724/application-of-multi-block-analysis-and-mixture-design-with-process-variable-for-development-of-chocolate-cake-containing-yacon-smallanthus-sonchifolius-and-maca-lepidium-meyenii
#6
Marcela Marta Lazaretti Tormena, Luana Tabalipa de Medeiros, Patrícia Casarin de Lima, Gabriela Possebon, Renata Hernandez Barros Fuchs, Evandro Bona
BACKGROUND: In this study, a chocolate cake formulation was developed with partial substitution of wheat flour by yacon and maca flour. A simplex-centroid design was applied to determine the proportions of the three flours and the amount of water was included as a process variable at three distinct levels. According to the overall acceptability of the cakes, the tasters were separated into two groups using the k-means. RESULTS: After segmentation, regression models were constructed for overall acceptability of each group, it is obtained R(2)ajusted values of 92...
January 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28075333/magnetic-resonance-study-of-bulk-and-thin-film-eutio3
#7
V V Laguta, S Kamba, M Maryško, B Andrzejewski, M Kachlík, K Maca, J H Lee, D G Schlom
Magnetic resonance spectra of EuTiO3 in both bulk and thin film form were taken at temperatures from 3-350 K and microwave frequencies from 9.2-9.8 and 34 GHz. In the paramagnetic phase, magnetic resonance spectra are determined by magnetic dipole and exchange interactions between Eu(2+) spins. In the film, a large contribution arises from the demagnetization field. From detailed analysis of the linewidth and its temperature dependence, the parameters of spin-spin interactions were determined: the exchange frequency is 10...
March 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28007001/antioxidant-and-neuroprotector-effect-of-lepidium-meyenii-maca-methanol-leaf-extract-against-6-hydroxy-dopamine-6-ohda-induced-toxicity-in-pc12-cells
#8
Ángel Rodríguez-Huamán, Sandra Casimiro-Gonzales, Jorge Antonio Chávez-Pérez, Carla Gonzales-Arimborgo, Richard Cisneros-Fernández, Luis Ángel Aguilar-Mendoza, Gustavo F Gonzales
Reactive oxygen species (ROS) are normally produced during cell metabolism, there is strong evidence to suggest that ROS produced in excess impair the cell and may be etiologically related to various neurodegenerative diseases. This study was undertaken to examine the effects of Lepidium meyenii (MACA) methanol leaf extract on neurotoxicity in PC12 cell exposed to 6-hydroxydopamine (6-OHDA). Fresh samples of "maca" leaves were processed in order to obtain foliar extracts and to evaluate the neurobiological activity on PC12 cells, subjected to the cytotoxic effect of 6-OHDA through the determination of the capacity antioxidant, cell viability and cytotoxicity assays on PC12 cells...
January 8, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27999448/thrombosis-related-abo-f5-mthfr-and-fgg-gene-polymorphisms-in-morbidly-obese-patients
#9
Kristina Kupcinskiene, Martyna Murnikovaite, Greta Varkalaite, Simonas Juzenas, Darius Trepenaitis, Ruta Petereit, Almantas Maleckas, Juozas Kupcinskas, Andrius Macas
Objective. Obesity is a well-known risk factor for thrombotic complications. The aim of the present study was to determine the frequency of thrombosis related ABO, F5, MTHFR, and FGG gene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals. Methods. Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m(2)) and 303 control individuals (BMI < 30 kg/m(2)) of European descent. ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) SNPs were genotyped by RT-PCR...
2016: Disease Markers
https://www.readbyqxmd.com/read/27803355/past-and-present-ards-mortality-rates-a-systematic-review
#10
REVIEW
Jan Máca, Ondřej Jor, Michal Holub, Peter Sklienka, Filip Burša, Michal Burda, Vladimír Janout, Pavel Ševčík
ARDS is severe form of respiratory failure with significant impact on the morbidity and mortality of critical care patients. Epidemiological data are crucial for evaluating the efficacy of therapeutic interventions, designing studies, and optimizing resource distribution. The goal of this review is to present general aspects of mortality data published over the past decades. A systematic search of the MEDLINE/PubMed was performed. The articles were divided according to their methodology, type of reported mortality, and time...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27793105/assessment-of-risk-factors-for-cerebral-oxygen-desaturation-during-neonatal-and-infant-general-anesthesia-an-observational-prospective-study
#11
Ilona Razlevice, Danguole C Rugyte, Loreta Strumylaite, Andrius Macas
BACKGROUND: Cerebral oxygen saturation (rSO2c) decrease from baseline greater than 20 % during infant cardiac surgery was associated with postoperative neurologic changes and neurodevelopmental impairment at 1 year of age. So far, there is no sufficient evidence to support the routine monitoring of rSO2c during general surgical procedures in children. We aimed to find out the frequency of cerebral desaturation 20 % or more from baseline and to identify possible predictors of change in cerebral oxygen saturation during neonatal and infant general surgery...
October 28, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27761703/intraoperative-floppy-iris-syndrome-and-its-association-with-various-concurrent-medications-bulbus-length-patient-age-and-gender
#12
Michael Wahl, Saskia M Tipotsch-Maca, Pia V Vecsei-Marlovits
PURPOSE: To evaluate the association between intraoperative floppy iris syndrome (IFIS) and concurrent medications containing selective alpha1A receptor antagonists as well as nonselective alpha1-adrenergic receptor antagonists, bulbus length, patient age and gender. METHODS: We performed a prospective data acquisition of IFIS occurrence and grading, and retrospective evaluation of concurrent medications, bulbus length, patient age and gender of all patients undergoing cataract surgery over a 6-month period...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27754971/perinatal-health-in-the-danube-region-new-birth-cohort-justified
#13
Lisbeth E Knudsen, Zorana J Andersen, Radim J Sram, Markéta Braun Kohlová, Eugen S Gurzau, Aleksandra Fucic, Laura Gribaldo, Pavel Rossner, Andrea Rossnerova, Vojtěch Máca, Iva Zvěřinová, Dagmar Gajdosova, Hanns Moshammer, Peter Rudnai, Milan Ščasný
In 2013-2015, a consortium of European scientists - NEWDANUBE - was established to prepare a birth cohort in the Danube region, including most of the countries with the highest air pollution in Europe, the area being one-fifth of the European Union's (EU's) territory, including 14 countries (nine EU member states), over 100 million inhabitants, with numerous challenges: big socioeconomic disparities, and a region-specific environmental pollution. The consortium reflects the EU Strategy for the Danube Region Strategy (2010), which identified 11 thematic Priority Areas - one of which is the environmental risks...
October 18, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27721369/applicability-of-impedance-cardiography-during-heart-failure-flare-ups
#14
Saulius Sadauskas, Albinas Naudžiūnas, Alvydas Unikauskas, Edita Mašanauskienė, Giedrė Bakšytė, Andrius Macas
BACKGROUND Heart failure (HF) accounts for about 5% of all causes of urgent hospital admissions, and the overall mortality of HF patients within 1 year after hospitalization is 17-45%. Transthoracic impedance cardiography (ICG) is a safe, non-invasive diagnostic technique that helps to detect various parameters that define different cardiac functions. The aim of this study was to investigate the value of ICG parameters in patients hospitalized due to HF flare-ups. MATERIAL AND METHODS The study included 60 patients (24 women and 36 men) who were admitted to intensive care units because of an acute episode of HF without signs of myocardial infarction...
October 9, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27719949/physicochemical-properties-of-maca-starch
#15
Ling Zhang, Guantian Li, Sunan Wang, Weirong Yao, Fan Zhu
Maca (Lepidium meyenii Walpers) is gaining research attention due to its unique bioactive properties. Starch is a major component of maca roots, thus representing a novel starch source. In this study, the properties of three maca starches (yellow, purple and black) were compared with commercially maize, cassava, and potato starches. The starch granule sizes ranged from 9.0 to 9.6μm, and the granules were irregularly oval. All the maca starches presented B-type X-ray diffraction patterns, with the relative degree of crystallinity ranging from 22...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27714596/analysis-of-the-appendicularia-class-subphylum-urochordata-as-a-possible-tool-for-biomonitoring-four-estuaries-of-the-tropical-region
#16
Pedro Freitas de Carvalho, Sérgio Luiz Costa Bonecker, Cristina Aparecida Gomes Nassar
This study aims to characterize the differences between physical and chemical parameters of water quality indicators and eutrophication in four estuaries of the state of Rio de Janeiro and relate them to full density of the species that belong to the Appendicularia class with the purpose of seeking bioindicators for estuarine areas. The estuaries studied were from the rivers Macaé, São João, Bracuí, and Perequê-Açu. The physicochemical parameters monitored for evaluation of the water bodies and used for the correlation with the appendicularians were pH, temperature, nitrite, nitrate, N-ammonia, total nitrogen, phosphate, total phosphorus, dissolved oxygen (DO), suspended particulate matter (SPM), chlorophyll a, heterotrophic bacteria, and fecal coliform...
November 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27708692/in-silico-profiling-for-secondary-metabolites-from-lepidium-meyenii-maca-by-the-pharmacophore-and-ligand-shape-based-joint-approach
#17
Fan Yi, Xiao-Lei Tan, Xin Yan, Hai-Bo Liu
BACKGROUND: Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS: The pharmacophore-based PharmaDB targets database screening joint the ligand shape similarity-based WEGA validation approach is proposed to predict the targets of these unique constituents and was performed using Discovery Studio 4...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27689623/alarmins-and-clinical-outcomes-after-major-abdominal-surgery-a-prospective-study
#18
Jan Máca, Filip Burša, Pavel Ševčík, Peter Sklienka, Michal Burda, Michal Holub
PURPOSE: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes. MATERIALS AND METHODS: We analyzed serum levels of alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, and S100A12; high-mobility group box 1; and heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days after surgery...
September 30, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27681650/effect-of-lepidium-meyenii-maca-on-testicular-function-of-mice-with-chemically-and-physically-induced-subfertility
#19
M Valdivia Cuya, K Yarasca De La Vega, G Lévano Sánchez, J Vásquez Cavero, H Temoche García, L Torres Torres, V Cruz Ornetta
The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice. After 35 days, the following groups of mice were evaluated: control, sham, chemical subfertility, chemical subfertility-maca-supplemented, physical subfertility, physical subfertility-maca-supplemented and maca-supplemented only. Motility (32.36% ± 5.34%) and sperm count (44.4 ± 5.37 × 10(6) /ml) in the chemically and physically subfertile mice (11.81% ± 4.06%, 17.34 ± 13...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27681649/red-maca-lepidium-meyenii-did-not-affect-cell-viability-despite-increased-androgen-receptor-and-prostate-specific-antigen-gene-expression-in-the-human-prostate-cancer-cell-line-lncap
#20
P Díaz, H Cardenas, P A Orihuela
We examined whether aqueous extract of Lepidium meyenii (red Maca) could inhibit growth, potentiate apoptotic activity of two anticancer drugs Taxol and 2-methoxyestradiol (2ME) or change mRNA expression for the androgen target genes, androgen receptor (Ar) and prostate-specific antigen (Psa) in the human prostate cancer cell line LNCaP. Red Maca aqueous extract at 0, 10, 20, 40 or 80 μg/ml was added to LNCaP cells, and viability was evaluated by the MTS assay at 24 or 48 hr after treatment. Furthermore, LNCaP cells were treated with 80 μg/ml of red Maca plus Taxol or 2ME 5 μM and viability was assessed 48 hr later...
October 2016: Andrologia
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