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https://www.readbyqxmd.com/read/28808386/in-vitro-inhibitory-effects-of-andrographis-paniculata-gynura-procumbens-ficus-deltoidea-and-curcuma-xanthorrhiza-extracts-and-constituents-on-human-liver-glucuronidation-activity
#1
Zulhilmi Husni, Sabariah Ismail, Mohd Halimhilmi Zulkiffli, Atiqah Afandi, Munirah Haron
BACKGROUND: Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza are commonly consumed as herbal medicines. However their effects on human liver glucuronidation activity are not yet evaluated. OBJECTIVE: In this study, we evaluate the inhibitory Effects of Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza extracts and their constituents on human liver glucuronidation activity. MATERIALS AND METHODS: Herbal extracts (aqueous, methanolic and ethanolic extracts) and their constituents were incubated with human liver microsomes with the addition of UDPGA to initiate the reaction...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807161/phytochemical-modulation-of-apoptosis-and-autophagy-strategies-to-overcome-chemoresistance-in-leukemic-stem-cells-in-the-bone-marrow-microenvironment
#2
Helen C Owen, Sandra Appiah, Noor Hasan, Lucy Ghali, Ghada Elayat, Celia Bell
Advances in scientific research and targeted treatment regimes have improved survival rates for many cancers over the past few decades. However, for some types of leukemia, including acute lymphoblastic and acute myeloid leukemia, mortality rates have continued to rise, with chemoresistance in leukemic stem cells (LSCs) being a major contributing factor. Most cancer drug therapies act by inducing apoptosis in dividing cells but are ineffective in targeting quiescent LSCs. Niches in the bone marrow, known as leukemic niches, behave as "sanctuaries" where LSCs acquire drug resistance...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801864/isolation-and-characterization-of-iron-chelators-from-turmeric-curcuma-longa-selective-metal-binding-by-curcuminoids
#3
Donald J Messner, Christine Surrago, Celia Fiordalisi, Wing Yin Chung, Kris V Kowdley
Iron overload disorders may be treated by chelation therapy. This study describes a novel method for isolating iron chelators from complex mixtures including plant extracts. We demonstrate the one-step isolation of curcuminoids from turmeric, the medicinal food spice derived from Curcuma longa. The method uses iron-nitrilotriacetic acid (NTA)-agarose, to which curcumin binds rapidly, specifically, and reversibly. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin each bound iron-NTA-agarose with comparable affinities and a stoichiometry near 1...
August 11, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28795782/variation-on-composition-and-bioactivity-of-essential-oils-of-four-common-curcuma-herbs
#4
Lanyue Zhang, Zhiwen Yang, Dingkang Chen, Zebin Huang, Yongliang Li, Xinzi Lan, Ping Su, Wanyi Pan, Wei Zhou, Xi Zheng, Zhiyun Du
Chemical compositions, antioxidative, antimicrobial, anti-inflammatory and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin and Curcuma kwangsiensis) rhizomes in China are comparatively studied. In total, 47, 49, 35 and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin and C. kwangsiensis essential oils by GC-MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36...
August 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28782139/low-doses-of-curcuma-longa-modulates-cell-migration-and-cell-cell-adhesion
#5
Paloma Santos de Campos, Bibiana Franzen Matte, Leonardo Francisco Diel, Luciano Henrique Jesus, Lisiane Bernardi, Alessandro Menna Alves, Pantelis Varvaki Rados, Marcelo Lazzaron Lamers
Cell invasion and metastasis are involved in clinical failures in cancer treatment, and both events require the acquisition of a migratory behavior by tumor cells. Curcumin is a promising natural product with anti-proliferative activity, but its effects on cell migration are still unclear. We evaluated the effects of curcumin on the proliferation, apoptosis, migration, and cell-cell adhesion of keratinocyte, oral squamous cell carcinoma (OSCC), and fibroblast cell lines, as well as in a xenograft model of OSCC...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28766664/tetrahydrocurcumin-is-more-effective-than-curcumin-in-inducing-the-apoptosis-of-h22-cells-via-regulation-of-a-mitochondrial-apoptosis-pathway-in-ascites-tumor-bearing-mice
#6
Weihai Liu, Zhenbiao Zhang, Guosheng Lin, Dandan Luo, Hanbin Chen, Hongmei Yang, Jiali Liang, Yuhong Liu, Jianhui Xie, Ziren Su, Hongying Cao
Curcumin (CUR), a widely used food additive, is derived mainly from Curcuma species that has been applied traditionally for the treatment of various diseases, including hepatocellular carcinoma (HCC). However, its poor systemic bioavailability hampers its clinical application, which may be related to its wide metabolism. Tetrahydrocurcumin (THC) is a major metabolite of CUR and has been reported to have multiple biologic activities. We investigated, for the first time, the efficacy and associated mechanism of action of THC and CUR in a H22 ascites tumor-bearing model in mice...
August 2, 2017: Food & Function
https://www.readbyqxmd.com/read/28764078/application-of-chemometrics-in-quality-control-of-turmeric-curcuma-longa-based-on-ultra-violet-fourier-transform-infrared-and-1-h-nmr-spectroscopy
#7
Haidy A Gad, Amel Bouzabata
Turmeric (Curcuma longa L.) belongs to the family Zingiberaceae that is widely used as a spice in food preparations in addition to its biological activities. UV, FT-IR, (1)H NMR in addition to HPLC were applied to construct a metabolic fingerprint for Turmeric in an attempt to assess its quality. 30 samples were analyzed, and then principal component analysis (PCA) and hierarchical clustering analysis (HCA) were utilized to assess the differences and similarities between collected samples. PCA score plot based on both HPLC and UV spectroscopy showed the same discriminatory pattern, where the samples were segregated into four main groups depending on their total curcuminoids content...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28761413/curcuma-longa-l-extract-improves-the-cortical-neural-connectivity-during-the-aging-process
#8
REVIEW
Gonzalo Flores
Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28747775/curcumin-and-curcuma-longa-l-extract-ameliorate-lipid-accumulation-through-the-regulation-of-the-endoplasmic-reticulum-redox-and-er-stress
#9
Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi, Han-Wool Chung, Yong-Chul Lee, Hyung-Ryong Kim, Ho Jeong Kwon, Han-Jung Chae
For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl4 treatment) and chronic-stress (every other day/4week CCl4 treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747591/assessment-of-genetic-and-chemical-variability-in-curcumae-longae-rhizoma-curcuma-longa-l-based-on-dna-barcoding-markers-and-hplc-fingerprints
#10
Zhonggang Duan, Wei Song, Kuan Chen, Xue Qiao, Min Ye
Curcumae Longae Rhizoma (Curcuma Longa L.) is an important traditional Chinese medicine with multiple beneficial effects. To elucidate the genetic and chemical differences among Curcumae Longae Rhizoma samples, three DNA barcoding markers (rbcL, matK, and ITS-LSU D1/D3) and HPLC fingerprinting were employed in this study. The discriminatory power of rbcL and matK was low, as they only detected one sequence type that showed 100% similarity with more than 20 congeneric species in the BOLD database. In contrast, ITS-LSU D1/D3 showed sufficient discriminatory power to precisely identify all of the market samples as C...
July 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28733192/pharmacological-evaluation-of-phytochemicals-from-south-indian-black-turmeric-curcuma-caesia-roxb-to-target-cancer-apoptosis
#11
K S Mukunthan, R S Satyan, T N Patel
Curcuma caesia Roxb. (Black turmeric), a perennial herb of the family Zingiberaceae is indigenous to India. C. caesia is used as a spice, food preservative and coloring agent commonly in the Indian subcontinent. Functional parametric pharmacological evaluations like drug ability and toxicity profile of this endangered species is poorly documented. In our present study, among all the extracts of dried C. caesia rhizome viz- hexane, ethyl acetate, methanol and water tested for free radical scavenging capacity by total antioxidant activity (TAO) method, Hexane Rhizome Extract (HRE) was found to possess remarkable activity (1200mg ascorbic acid equivalent/100g)...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28732813/a-randomized-double-blind-placebo-controlled-study-on-the-anti-haemostatic-effects-of-curcuma-longa-angelica-sinensis-and-panax-ginseng
#12
Foon Yin Fung, Wan Hui Wong, Seng Kok Ang, Hwee Ling Koh, Mei Ching Kun, Lai Heng Lee, Xiaomei Li, Heng Joo Ng, Chuen Wen Tan, Yan Zhao, Yeh Ching Linn
PURPOSE: Herbs with "blood-activating" properties by traditional medicine theory often raise concerns for their possible anti-platelet or anticoagulation effects based on reports from in vitro studies. Such herbs have been implicated for bleeding manifestations based on only anecdotal reports. In particular, the combination of such herbs with anti-platelet agents is often empirically advised against despite lack of good clinical evidence. Here we studied 3 commonly used herbal preparations Curcuma longa, Angelica sinensis and Panax ginseng on their respective anti-platelet and anticoagulation effect, alone and in combination with aspirin...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28726500/chemical-constituents-from-curcuma-longa-l-and-their-inhibitory-effects-of-nitric-oxide-production
#13
Ting Yuan, Cuiyun Zhang, Chongyue Qiu, Guiyang Xia, Fei Wang, Bin Lin, Hua Li, Lixia Chen
A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using (1)H NMR, (13)C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1-7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264...
July 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28724959/hepatic-metabolic-effects-of-curcuma-longa-extract-supplement-in-high-fructose-and-saturated-fat-fed-rats
#14
Fabrice Tranchida, Zo Rakotoniaina, Laetitia Shintu, Léopold Tchiakpe, Valérie Deyris, Mehdi Yemloul, Pierre Stocker, Nicolas Vidal, Odile Rimet, Abel Hiol, Stefano Caldarelli
The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724858/antibacterial-effect-of-azadirachta-indica-neem-or-curcuma-longa-turmeric-against-enterococcus-faecalis-compared-with-that-of-5-sodium-hypochlorite-or-2-chlorhexidine-in-vitro
#15
Dakshita Joy Sinha, Kanwar D S Nandha, Natasha Jaiswal, Agrima Vasudeva, Shashi Prabha Tyagi, Udai Pratap Singh
The purpose of this study was to compare the antibacterial properties of Azadirachta indica (neem) or Curcuma longa (turmeric) against Enterococcus faecalis with those of 5% sodium hypochlorite or 2% chlorhexidine as root canal irrigants in vitro. The activity of neem, chlorhexidine, sodium hypochlorite, or turmeric against E. faecalis was measured on agar plates using the agar diffusion method. The tube dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the irrigants used...
2017: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/28723615/nanoformulations-of-curcumin-an-emerging-paradigm-for-improved-remedial-application
#16
REVIEW
Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722473/distribution-and-diversity-of-twelve-curcuma-species-in-china
#17
Lanyue Zhang, Jingwen Wei, Zhiwen Yang, Feng Chen, Qiqiu Xian, Ping Su, Wanyi Pan, Kun Zhang, Xi Zheng, Zhiyun Du
Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces. The simulated current distributions are close to the actual distribution regions...
July 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28721737/a-new-water-soluble-nanomicelle-formed-through-self-assembly-of-pectin-curcumin-conjugates-preparation-characterization-and-anticancer-activity-evaluation
#18
Feng Bai, Jiajing Diao, Ying Wang, Shixin Sun, Hongmei Zhang, Yunyun Liu, Yanqing Wang, Jian Cao
Curcumin is a dominating active component of Curcuma longa and has been studied widely because of its prominent biological activities. The extremely low aqueous solubility, stability, and bioavailability of curcumin limit its application in the field of medicine. In this study, we developed pectin-curcumin (PEC-CCM) conjugates that could self-assemble water-soluble nanomicelles in aqueous solution. The structure of PEC-CCM conjugates was characterized by ultraviolet-visible spectra, fluorescence spectra, Fourier transform infrared spectroscopy, and (1)H nuclear magnetic resonance spectroscopy...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28719145/preparation-of-carbon-dot-based-ratiometric-fluorescent-probes-for-cellular-imaging-from-curcuma-longa
#19
Zihnil Adha Islamy Mazrad, Eun Bi Kang, Insik In, Sung Young Park
This work derived biocompatible and stable probes based on fluorescent nanoparticles (FNPs) from a natural source, Curcuma longa. The multi-color fluorescence emissions from carbonized Curcuma longa (C-FNPs) obtained through defined dehydration conditions are soluble in water and have a small particle size (~17 nm). The surface passivation with polyethylene glycol (PEG) capped with amine groups in FNPs (P-FNPs) generated a probe with a higher quantum yield and longer fluorescence lifetime than obtained with C-FNPs...
July 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28716085/the-protective-effect-of-fermented-curcuma-longa-l-on-memory-dysfunction-in-oxidative-stress-induced-c6-gliomal-cells-proinflammatory-activated-bv2-microglial-cells-and-scopolamine-induced-amnesia-model-in-mice
#20
Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee, Seun-Ah Yang
BACKGROUND: Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented C. longa (FCL) has not been reported. Therefore, in this study, the effectiveness of FCL for the regulation of memory dysfunction was investigated in two brain cell lines (rat glioma C6 and murine microglia BV2) and scopolamine-treated mice. METHODS: C. longa powder was fermented by 5% Lactobacillus plantarum K154 containing 2% (w/v) yeast extract at 30 °C for 72 h followed by sterilization at 121 °C for 15 min...
July 17, 2017: BMC Complementary and Alternative Medicine
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