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https://www.readbyqxmd.com/read/29147872/fluidized-bed-hot-melt-granulation-as-a-tool-to-improve-curcuminoid-solubility
#1
Cristiane C C Teixeira, Elias de Paiva Junior, Luis Alexandre Pedro de Freitas
Curcumin is the main bioactive component of Curcuma longa L. and has recently aroused growing interest from the scientific community. Unfortunately, the medicinal properties attributed to curcuminoids are impaired by their low oral bioavailability or low solubility in aqueous solutions. Many strategies have been studied to improve curcumin solubility; however, the preparation of granules using hydrophilic materials has never been attempted. The aim of this work was to develop curcumin granules by fluidized bed hot-melt granulation using the hydrophilic carrier Gelucire® 50:13...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29146529/inhibitory-effect-of-the-extract-of-rhizome-of-curcuma-longa-l-in-gelatinase-activity-and-its-effect-on-human-skin
#2
Keiko Muta, Shinji Inomata, Tadao Fukuhara, Junko Nomura, Toshio Nishiyama, Yoh-Ichi Tagawa, Satoshi Amano
Exposure to UV radiation to human skin up-regulates the synthesis of matrix metalloproteinase (MMP) family. Gelatinases are member of MMPs which have been suggested to play an important role in photoaging such as wrinkle formation. To inhibit gelatinase activity is regarded to be very important to keep healthy skin and to protect wrinkle formation. On the other hand, anti-photoaging agents are expected to be derived from natural resources, especially plants. Plant extracts having gelatinase-inhibitory effect that might be used as safe anti-photoaging ingredient were widely screened...
November 13, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29142438/molecular-simulation-based-combinatorial-modeling-and-antioxidant-activities-of-zingiberaceae-family-rhizomes
#3
Talambedu Usha, Sushen Pradhan, Arvind Kumar Goyal, Shanmugarajan Dhivya, H P Prashanth Kumar, Manoj Kumar Singh, Neelu Joshi, Bharat Chandra Basistha, K R Siddalinga Murthy, Saravanakumar Selvaraj, Sushil Kumar Middha
Objective: The main aim of this scientific report was to investigate a series of phytochemicals in silico and the pharmacology of four plants found at higher altitude in the ginger family, Zingiberaceae (incl. Costaceae) from North-East India, particularly Sikkim. First, the goal was to determine the biological activities of the four herbs (used under Zingiberaceae family) using antioxidant assays to identify the best species. Second, previously reported compounds in litero were subsequently screened for their anticancerous activities using in silico methods...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142426/in-silico-and-in-vitro-anticancer-activity-of-isolated-novel-marker-compound-from-chemically-modified-bioactive-fraction-from-curcuma-longa-nccl
#4
Arshi Naqvi, Richa Malasoni, Swati Gupta, Akansha Srivastava, Rishi R Pandey, Anil Kumar Dwivedi
Background: Turmeric (Curcuma longa) is reported to possess wide array of biological activities. Herbal Medicament (HM) is a standardized hexane-soluble fraction of C. longa and is well known for its neuroprotective effect. Objective: In this study, we attempted to synthesize a novel chemically modified bioactive fraction from HM (NCCL) along with isolation and characterization of a novel marker compound (I). Materials and Methods: NCCL was prepared from HM...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142423/bioactive-turmerosaccharides-from-curcuma-longa-extract-nr-inf-02-potential-ameliorating-effect-on-osteoarthritis-pain
#5
Bharathi Bethapudi, Sasikumar Murugan, Ramanaiah Illuri, Deepak Mundkinajeddu, Chandrasekaran Chinampudur Velusami
Background: Curcuma longa has long history of medicinal use in Ayurveda. A unique product NR-INF-02 was prepared from C. longa that was standardized to contain turmerosaccharides. Objective: The present study investigated the effect of turmerosaccharides rich fraction of NR-INF-02 on monosodium iodoacetate (MIA)-induced OA pain animal model that mimics human OA. Further, the analgesic effect of turmerosaccharides rich fraction was compared to turmerosaccharides less fraction of NR-INF-02...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29136820/fluorescent-ligand-fishing-combination-with-in-situ-imaging-and-characterizing-to-screen-hsp-90-inhibitors-from-curcuma-longa-l-based-on-inp-zns-quantum-dots-embedded-mesoporous-nanoparticles
#6
Yue Hu, Anchen Fu, Zhaoyi Miao, Xiaojing Zhang, Tianlin Wang, An Kang, Jinjun Shan, Dong Zhu, Wei Li
Although ligand fishing has been shown to be an efficient technique for the identification of bioactive components from complex mixtures such as natural products, it cannot be applied to biomedical image processing. Herein, a specific fluorescent ligand fishing combined with in situ imaging approach is presented for the identification of heat shock protein 90 (Hsp 90) inhibitors from complex matrixes, Curcuma longa L., using N-terminus immobilized Hsp 90α functionalized InP/ZnS quantum dots embedded mesoporous nanoparticles (i...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29126713/turmeric-curcuma-longa-mirnas-and-their-regulating-targets-are-involved-in-development-and-secondary-metabolite-pathways
#7
Noopur Singh, Ashok Sharma
Turmeric has been used as a therapeutic herb over centuries in traditional medicinal systems due to the presence of several secondary metabolite compounds. microRNAs are known to regulate gene expression at the post-transcriptional level by transcriptional cleavage or translation repression. miRNAs have been demonstrated to play an active role in secondary metabolism regulation. The present work was focused on the identification of the miRNAs involved in the regulation of secondary metabolite and development process of turmeric...
November 7, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29115589/anti-neuroinflammatory-effect-of-curcumin-on-pam3csk4-stimulated-microglial-cells
#8
Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
Curcumin is the main curcuminoid present in Curcuma longa and it has been previously reported to exhibit a wide range of pharmacological activities. In the present study, the inhibitory effects of curcumin on the inflammatory mediators released by Pam3CSK4-stimulated BV-2 microglial cells were investigated. The production of pro-inflammatory mediators and cytokines, including tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2), were measured by enzyme‑linked immunosorbent assay (ELISA). The expression of inflammatory genes, including inducible nitric oxide synthase and cyclooxygenase-2, were further investigated using reverse transcription-quantitative polymerase chain reaction...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114361/meiotic-behaviour-and-its-implication-on-species-inter-relationship-in-the-genus-curcuma-linnaeus-1753-zingiberaceae
#9
Judith Mary Lamo, Satyawada Rama Rao
In this paper, detailed meiotic analysis was investigated in seven species of Curcuma (Linnaeus, 1753) which can contribute significantly to our understanding about species inter-relationship, speciation and evolution. The species were divided into two groups viz., Group I having 2n = 42 (C. comosa Roxburgh, 1810, C. haritha Mangaly & M.Sabu, 1993, C. mangga Valeton & Zijp, 1917, and C. motana Roxburgh, 1800) and Group II with 2n = 63 (C. caesia Roxburgh, 1810, C. longa Linnaeus, 1753 and C. sylvatica Valeton, 1918)...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/29102767/curcuzedoalide-contributes-to-the-cytotoxicity-of-curcuma-zedoaria-rhizomes-against-human-gastric-cancer-ags-cells-through-induction-of-apoptosis
#10
Eun Bee Jung, Tuy An Trinh, Tae Kyoung Lee, Noriko Yamabe, Ki Sung Kang, Ji Hoon Song, Sungyoul Choi, Sang Hyun Lee, Tae Su Jang, Ki Hyun Kim, Gwi Seo Hwang
ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma zedoaria Roscoe (Zingiberaceae), also known as white turmeric or zedoaria, has been used in Ayurveda and traditional Chinese medicine to treat various cancers, and it possesses several sesquiterpenoid compounds. OBJECTIVE: This study aimed to evaluate the therapeutic effects of a methanolic (MeOH) extract of C. zedoaria rhizomes, as well as its active constituents, against gastric cancer, which is a frequently diagnosed cancer in South Korea...
November 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29095653/curcuma-longa-turmeric-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-pilot-study
#11
Vanessa Armenio Scontre, Janine Capobiango Martins, Claudia Vaz de Melo Sette, Haila Mutti, Daniel Cubero, Fernando Fonseca, Auro Del Giglio
Hand-foot syndrome (HFS) is common and frequently occurs in the first cycle of treatment in approximately 40% to 50% of patients who receive capecitabine. Turmeric (Curcuma longa) is a plant used in Ayurvedic medicine with clinical activity in various inflammatory conditions. Our objective was to evaluate whether turmeric was active for the prevention of capecitabine-induced HFS. We included patients older than 18 years of age without previous exposure to capecitabine who were scheduled to receive this medication...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29080615/antiviral-activity-of-five-asian-medicinal-pant-crude-extracts-against-highly-pathogenic-h5n1-avian-influenza-virus
#12
Benjaporn Sornpet, Teerapong Potha, Yingmanee Tragoolpua, Kidsadagon Pringproa
OBJECTIVE: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus (H5N1). METHODS: Crude extracts of Andrographis paniculata, Curcuma longa (C. longa), Gynostemma pentaphyllum, Kaempferia parviflora (K. parviflora), and Psidium guajava obtained by both water and ethanol extractions were investigated for their cytotoxicity in the Madin-Darby canine kidney cells. Thereafter, they were investigated in vitro for antiviral activity and cytokine response upon H5N1 virus infection...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29080464/curcumin-and-endometriosis-review-on-potential-roles-and-molecular-mechanisms
#13
REVIEW
Tahereh Arablou, Roya Kolahdouz-Mohammadi
Endometriosis, an estrogen-dependent inflammatory disease, is one of the most common chronic gynecological disorders affecting women in reproductive age. It is characterized by the presence of endometrial-like tissue outside the uterus. The exact pathophysiology of endometriosis is not still well-known, but the immune system and inflammation have been considered as pivotal factors in disease progression. Turmeric, an important spice all around the world, is obtained from the rhizomes of Curcuma longa, a member of the Zingiberaceae family...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080451/curcumin-sensitizes-lymphoma-cells-to-dna-damage-agents-through-regulating-rad51-dependent-homologous-recombination
#14
Qian Zhao, Jiawei Guan, Yuanhua Qin, Peng Ren, Zhiwei Zhang, Jian Lv, Shijie Sun, Cuili Zhang, Weifeng Mao
Curcumin is a natural compound isolated from the rhizome of Curcuma longa. It possesses anti-tumor activity through arresting cell cycles and promoting cell apoptosis. However, the effect of curcumin on DNA damage is not well defined. In this study, we investigated the effect of curcumin on inducing DNA damage and on sensitizing lymphoma cells to anti-tumoral DNA damage drugs. Western blot showed curcumin induced γ-H2AX foci in CH12F3 lymphoma cells, which suggests curcumin induces DNA breaks. In addition, curcumin decreased the expression of Rad51, which suggests curcumin induces DNA damage through regulating Rad51-dependant homologous recombination...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29070773/determination-of-the-marker-diarylheptanoid-phytoestrogens-in-curcuma-comosa-roxb-rhizomes-and-selected-herbal-medicinal-products-by-hplc-dad
#15
Bancha Yingngam, Adelheid H Brantner, Damrongsak Jinarat, Rawiwun Kaewamatawong, Wandee Rungseevijitprapa, Apichart Suksamrarn, Pawinee Piyachaturawat, Ratchanaporn Chokchaisiri
A method for quantification of diarylheptanoids in Curcuma comosa rhizomes and selected pharmaceutical preparations was established by using HPLC-DAD. The chromatographic separation of three diarylheptanoids [(3S)-1-(3,4-dihydroxy-phenyl)-7-phenyl-(6E)-6-hepten-3-ol (1), (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (2), and (3S)-1,7-diphenyl-(6E)-6-hepten-3-ol (3)] was performed on a Luna C18 analytical column using gradient elution with 0.5% acetic acid in water and acetonitrile with a flow rate of 1 mL/min and a column temperature of 35 °C...
October 26, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29070088/effect-of-turmeric-on-the-viability-ovarian-folliculogenesis-fecundity-ovarian-hormones-and-response-to-luteinizing-hormone-of-rabbits
#16
A V Sirotkin, A Kadasi, A Stochmalova, A Balazi, M Földesiová, P Makovicky, P Chrenek, A H Harrath
The present study investigated whether dietary turmeric (Curcuma longa L.) can improve rabbit reproduction, ovarian function, growth, or viability. Female New Zealand White rabbits were either fed a standard diet (n=15) or a diet enriched with 5 g (group E1) or 20 g (group E2) turmeric powder per 100 kg feed mixture (n=16 or 15, respectively). After 295 days, weight gain, conception and kindling rates, pup and mother viability, ovarian macro- and micro-morphometric indices, release of leptin in response to the addition LH, and the release of progesterone, testosterone and leptin by isolated ovarian fragments were analyzed...
October 26, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29055920/curcumin-in-hepatobiliary-disease-pharmacotherapeutic-properties-and-emerging-potential-clinical-applications
#17
Robert W Hu, Elizabeth J Carey, Keith D Lindor, James H Tabibian
Curcumin, an aromatic phytoextract from the turmeric (Curcuma longa) rhizome, has been used for centuries for a variety of purposes, not the least of which is medicinal. A growing body of evidence suggests that curcumin has a broad range of potentially therapeutic pharmacological properties, including anti-inflammatory, anti-fibrotic, and anti-neoplastic effects, among others. Clinical applications of curcumin have been hampered by quality control concerns and limited oral bioavailability, although novel formulations appear to have largely overcome these issues...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#18
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29052850/curcumin-hemostasis-thrombosis-and-coagulation
#19
REVIEW
Faeze Keihanian, Amin Saeidinia, Ramin Khameneh Bagheri, Thomas P Johnston, Amirhossein Sahebkar
Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particularly in hemostasis and the coagulation process, as well as altering platelet function tests and some coagulation parameters. Curcumin is a polyphenol derived from the Curcuma longa plant and has been used extensively in complementary and alternative medicine, as it is nontoxic and safe with various therapeutic properties...
October 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29048630/metastatic-genes-targeted-by-an-antioxidant-in-an-established-radiation-%C3%A2-and-estrogen-breast-cancer-model
#20
Gloria M Calaf, Debasish Roy
Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates that relapses occurring after radiotherapy are associated with increased metastatic potential and poor prognosis in the breast. Among the anticarcinogenic and antiproliferative agents, curcumin is a well-known major dietary natural yellow pigment derived from the rhizome of the herb Curcuma longa (Zingiberaceae)...
September 14, 2017: International Journal of Oncology
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