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https://www.readbyqxmd.com/read/28319408/turmeric-extract-inhibits-apoptosis-of-hippocampal-neurons-of-trimethyltin-exposed-rats
#1
S Yuliani, S Widyarini, Mustofa, G Partadiredja
OBJECTIVES: The aim of the present study was to reveal the possible antiapoptotic effect of turmeric (Curcuma longa Linn.) on the hippocampal neurons of rats exposed to trimethyltin (TMT). BACKGROUND: Oxidative damage in the hippocampus can induce the apoptosis of neurons associated with the pathogenesis of dementiaMETHODS. The ethanolic turmeric extract and a citicoline (as positive control) solution were administered to the TMT-exposed rats for 28 days. The body weights of rats were recorded once a week...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#2
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28303780/purity-evaluation-of-curcuminoids-in-the-turmeric-extract-obtained-by-accelerated-solvent-extraction
#3
Dinesh K Yadav, Khushbu Sharma, Anirban Dutta, Aditi Kundu, Akanksha Awasthi, Arnab Goon, Kaushik Banerjee, Supradip Saha
Curcuminoids, the active principle of <i>Curcuma longa </i>L, is one of the most researched subjects worldwide for its broad-spectrum biological activities. Being traditionally known for their anticancer properties and issues related to bioavailability, the curcuminoids, including diferuloylmethane (curcumin), have gained special attention. Thus, the current study focused on the purity profiling of curcuminoids when extracted by accelerated solvent extraction, which was run with turmeric rhizome powder (20 g) at 1500 psi and at 50°C, with a static time of 10 min and with three cycles...
March 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28293392/the-effect-of-hydro-ethanolic-extract-of-curcuma-longa-rhizome-and-curcumin-on-total-and-differential-wbc-and-serum-oxidant-antioxidant-biomarkers-in-rat-model-of-asthma
#4
Farzaneh Shakeri, Mohammad Soukhtanloo, Mohammad Hossein Boskabady
OBJECTIVES: The effects of Curcuma longa (C. longa) and curcumin on total and differential WBC count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. MATERIALS AND METHODS: Total and differential WBC count in the blood, NO2, NO3, MDA, SOD, CAT and thiol levels in serum were examined in control, asthma, Asthmatic rats treated with C. longa (0.75, 1.50, and 3.00 mg/ml), curcumin (0.15, 0.30, and 0.60 mg/ml), and dexamethasone (1.25 μg/ml) rats...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28291961/attenuation-of-oxidative-stress-induced-osteoblast-apoptosis-by-curcumin-is-associated-with-preservation-of-mitochondrial-functions-and-increased-akt-gsk3%C3%AE-signaling
#5
Panpan Dai, Yixin Mao, Xiaoyu Sun, Xumin Li, Ibrahim Muhammad, Weiyan Gu, Dafeng Zhang, Yu Zhou, Jianfeng Ma, Zhenyu Ni, Shengbin Huang
BACKGROUND: Osteoblast apoptosis induced by oxidative stress plays a crucial role in the development and progression of osteoporosis. Curcumin, a natural antioxidant isolated from Curcuma longa, has highly protective effects against osteoporosis. However, the effects of curcumin on oxidative stress-induced osteoblast apoptosis remain unclear. This study aimed to explore the effect of curcumin on hydrogen peroxide (H2O2) induced osteoblast apoptosis and the underlying mechanisms. METHODS: An osteoblastic cell line (Saos-2) was exposed to various concentrations of H2O2 with or without curcumin treatment...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28288756/antiparasitic-efficacy-of-curcumin-from-curcuma-longa-against-ichthyophthirius-multifiliis-in-grass-carp
#6
Yan-Meng Liu, Qi-Zhong Zhang, De-Hai Xu, Yao-Wu Fu, De-Jie Lin, Sheng-Yu Zhou, Jian-Pei Li
Ichthyophthirius multifiliis is a ciliated parasite that elicits great economic losses in aquaculture. In the present study, a polyphenol compound, curcumin, was obtained from the rhizome of Curcuma longa by bioassay-guided isolation based on the efficacy of anti-I. multifiliis theronts. Anti-I. multifiliis efficacy of curcumin was evaluated in vitro and in vivo. Curcumin resulted in 100% mortality of I. multifiliis theronts at a concentration of 1mg/L within 21.7±1.2min and killed all tomonts at 8mg/L within 31...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28287280/comparison-of-antioxidant-anticholinesterase-and-antidiabetic-activities-of-three-curcuminoids-isolated-from-curcuma-longa-l
#7
Zeynep Kalaycıoğlu, Işıl Gazioğlu, F Bedia Erim
Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity...
March 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28283087/bisdemethoxycurcumin-enhances-x-ray-induced-apoptosis-possibly-through-p53-bcl-2-pathway
#8
Atsushi Enomoto, Junko Yamada, Akinori Morita, Kiyoshi Miyagawa
Bisdemethoxycurcumin (BDMC), which is isolated from the rhizomes of Curcuma longa, has anti-inflammatory and anti-carcinogenic activities. Here we found that BDMC enhanced X-ray-induced apoptosis in human T-cell leukemia MOLT-4 cells. Knockdown of p53 significantly attenuated the radiosensitizing effect of BDMC. However, BDMC did not enhance X-ray-mediated activation of the p53 signaling pathway via p53's transactivation or mitochondrial translocation. On the other hand, BDMC promoted the X-ray-induced dephosphorylation at Ser 70 in Bcl-2's flexible loop regulatory domain and Bcl-2 binding to p53...
March 2017: Mutation Research
https://www.readbyqxmd.com/read/28281678/a-glycyrrhetinic-acid-modified-curcumin-supramolecular-hydrogel-for-liver-tumor-targeting-therapy
#9
Guoqin Chen, Jinliang Li, Yanbin Cai, Jie Zhan, Jie Gao, Mingcai Song, Yang Shi, Zhimou Yang
Curcumin (Cur), a phenolic anti-oxidant compound obtained from Curcuma longa plant, possesses a variety of therapeutic properties. However, it is suffered from its low water solubility and low bioavailability property, which seriously restricts its clinical application. In this study, we developed a glycyrrhetinic acid (GA) modified curcumin supramolecular pro-gelator (GA-Cur) and a control compound Nap-Cur by replacing GA with the naphthylacetic acid (Nap). Both compounds showed good water solubility and could form supramolecular gels by disulfide bond reduction triggered by glutathione (GSH) in vitro...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28278495/antioxidant-supplements-and-gastrointestinal-diseases-a-critical-appraisal
#10
Islam Khan, Sue E Samson, Ashok Kumar Grover
The gastrointestinal tract digests and absorbs dietary nutrients; protects the body against physical and chemical damage from contents in its lumen; provides immunity against external antigens and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome, inflammatory bowel disease which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions...
March 8, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#11
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28274852/curcumin-as-a-potential-protective-compound-against-cardiac-diseases
#12
REVIEW
Shuai Jiang, Jing Han, Tian Li, Zhenlong Xin, Zhiqiang Ma, Wencheng Di, Wei Hu, Bing Gong, Shouyin Di, Dongjin Wang, Yang Yang
Curcumin, which was first used 3000 years ago as an anti-inflammatory agent, is a well-known bioactive compound derived from the active ingredient of turmeric (Curcuma longa). Previous research has demonstrated that curcumin has immense therapeutic potential in a variety of diseases via anti-oxidative, anti-apoptotic, and anti-inflammatory pathways. Cardiac diseases are the leading cause of mortality worldwide and cause considerable harm to human beings. Numerous studies have suggested that curcumin exerts a protective role in the human body whereas its actions in cardiac diseases remain elusive and poorly understood...
March 6, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28274631/curcumolide-reduces-diabetic-retinal-vascular-leukostasis-and-leakage-partly-via-inhibition-of-the-p38mapk-nf-%C3%AE%C2%BA-b-signaling
#13
Yuan Cai, Wencan Li, Hongfeng Tu, Nanmei Chen, Zhipeng Zhong, Pengcheng Yan, Jianyong Dong
Retinal inflammation in a hyperglycemic condition is believed to play a crucial role in the development of diabetic retinopathy, and targeting inflammatory mediators is a promising strategy for the control of diabetic retinopathy. Curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from Curcuma wenyujin. In this study, we demonstrate that treatment with curcumolide alleviated retinal inflammatory activities both in vitro and in vivo in a STZ-induced diabetic rat model and in TNF-α-stimulated HUVECs...
February 22, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28274102/production-of-curcuminoids-in-engineered-escherichia-coli
#14
Eun Ji Kim, Mi Na Cha, Bog-Gyu Kim, Joong-Hoon Ahn
Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa, possesses diverse pharmacological properties including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activity. Two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in Escherichia coli. PAL (phenylalanine ammonia lyase) or TAL (tyrosine ammonia lyase), along with Os4CL (p-coumaroyl-CoA ligase) and CUS (curcumin synthase), were introduced in to E. coli, and each strain produced dicinnamoylmethane or bisdemethoxycurcumin, respectively...
March 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28272691/the-effect-of-curcumin-on-bladder-tumor-in-rat-model
#15
Z-J Pan, N Deng, Z-H Zou, G-X Chen
OBJECTIVE: Bladder cancer is the most commonly malignant tumor in the urogenital tract, only next to prostate cancer with a higher incidence in China. Curcumin is the major component of curcuma longa and has multiple biological effects including anti-tumor. This study aimed to investigate the effect of curcumin on bladder cancer. MATERIALS AND METHODS: SPF-grade Wistar rats were used for establishing bladder cancer model through injection of N-methyl-N-nitrosourea (MNU)...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28272397/-phaeocaulin-a-d-four-pairs-of-new-enantiomeric-germacrane-type-sesquiterpenes-from-curcuma-phaeocaulis-as-natural-nitric-oxide-inhibitors
#16
Gui-Yang Xia, De-Juan Sun, Jiang-Hao Ma, Yue Liu, Feng Zhao, Paul Owusu Donkor, Li-Qin Ding, Li-Xia Chen, Feng Qiu
Germacrane-type sesquiterpenes, with a flexible 10-membered ring unit as the structural and conformational features, play a central role in the biosynthesis and synthesis of other sesquiterpenes. In this report, two pairs of new sesquiterpene alkaloids, (+)/(-)-phaeocaulin A [(+)-1/(-)-1] and B [(+)-2/(-)-2], and two pairs of new sesquiterpenes, (+)/(-)-phaeocaulin C [(+)-3/(-)-3] and D [(+)-4/(-)-4], along with one related known analog (5), were isolated from the rhizomes of Curcuma phaeocaulis. The absolute configurations of (+)-1/(-)-1, (+)-2/(-)-2, (+)-3/(-)-3 and (+)-4/(-)-4 were unambiguously determined by analysis of single-crystal X-ray diffractions and quantum chemical electronic circular dichroism (ECD) method...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264204/new-curcumin-loaded-chitosan-nanocapsules-in-vivo-evaluation
#17
Edgar Marin, Maria Isabel Briceño, Alicia Torres, Catherina Caballero-George
The medicinal applications of curcumin, the major component of Curcuma longa, are limited by its poor solubility and low oral bioavailability. In order to overcome this limitation, a method to produce nanocapsules of chitosan loaded with curcumin was developed. Three different molecular weight and deacetylation degree chitosan polymers were used in the formulation in order to prepare curcumin-loaded nanocapsules (mass ratio 1 : 1.4). The best results were achieved using chitosan-Bi with a molecular weight of 710 000 Da...
March 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28259961/microrna-7-functions-as-a-tumor-suppressor-gene-by-regulating-ilf2-in-pancreatic-carcinoma
#18
Yiliang Bi, Wei Shen, Min Min, Yan Liu
Interleukin enhancer binding factor 2 (ILF2) has been found to be markedly upregulated in pancreatic carcinoma and is involved in the pathogenesis of pancreatic carcinoma. Thus, ILF2 may be a potential target for therapy. Yet, the regulatory mechanisms of ILF2 in pancreatic carcinoma remain largely elusive. In the present study, we demonstrated that ILF2 functioned as an oncogene and regulated epithelial-mesenchymal transition (EMT)-associated genes in pancreatic carcinoma PANC-1 cells. MicroRNA-7 (miR-7) suppressed ILF2 mRNA expression and the protein level in PANC-1 cells...
February 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28258675/cancer-chemoprevention-selected-molecular-mechanisms
#19
Katarzyna Walczak, Sebastian Marciniak, Grażyna Rajtar
The effect of diet on cancer formation and prevention of carcinogenesis has attracted considerable attention for years and is the subject of several studies. Some components of the daily diet, such as resveratrol, curcumin, genistein, gingerol, can significantly reduce the risk of cancer or affect the rate of tumor progression. Cancer chemoprevention assumes the use of natural or synthetic biologically active substances in order to prevent, inhibit or reverse the progression of cancer. There are many biologically active compounds in several natural products, i...
March 2, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28255816/morphological-analysis-of-vessel-elements-for-systematic-study-of-three-zingiberaceae-tribes
#20
Kathlyn Vasconcelos Gevú, Helena Regina Pinto Lima, John Kress, Maura Da Cunha
Zingiberaceae containing over 1,000 species that are divided into four subfamilies and six tribes. In recent decades, there has been an increase in the number of studies about vessel elements in families of monocotyledon. However, there are still few studies of Zingiberaceae tribes. This study aims to establish systematic significance of studying vessel elements in two subfamilies and three tribes of Zingiberaceae. The vegetative organs of 33 species processed were analysed by light and scanning electron microscopy and Principal Component Analysis was used to elucidate genera boundaries...
March 2, 2017: Journal of Plant Research
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