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https://www.readbyqxmd.com/read/28321398/unveiling-the-metabolic-changes-on-muscle-cell-metabolism-underlying-p-phenylenediamine-toxicity
#1
Igor Marín de Mas, Silvia Marín, Gisela Pachón, Juan C Rodríguez-Prados, Pedro Vizán, Josep J Centelles, Romà Tauler, Amaya Azqueta, Vitaly Selivanov, Adela López de Ceraín, Marta Cascante
Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase (CK) and myoglobulin, and is frequently accompanied by myoglobinuria. In the present work, we evaluated the toxicity of p-phenylenediamine (PPD), a main component of hair dyes which is reported to induce rhabdomyolysis. We studied the metabolic effect of this compound in vivo with Wistar rats and in vitro with C2C12 muscle cells...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28303511/macro-and-microelement-status-in-animal-and-human-hypertension-the-role-of-the-ace-gene-i-d-polymorphism
#2
Olena Pavlyushchik, Viktor Afonin, Svetlana Fatykhava, Polina Shabunya, Viktoryia Sarokina, Aliaksandr Khapaliuk
Genetic factors that predispose to hypertension may contribute to element disturbances observed in hypertensive patients. We tested the hypothesis that the deletion allele of the angiotensin-converting enzyme (ACE) gene is associated with element imbalances in hypertension. The concentrations of elements in genetically predisposed to hypertension rats (SHRs) and their controls (WKY rats) were also examined. ICP-MS was used for elemental analysis of human hair and animal fur. Genotyping was performed by PCR...
March 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28290603/fenofibrate-exerts-protective-effects-against-gentamicin-induced-toxicity-in-cochlear-hair-cells-by-activating-antioxidant-enzymes
#3
Channy Park, Hye-Min Ji, Se-Jin Kim, Sung-Hee Kil, Joon No Lee, Seongae Kwak, Seong-Kyu Choe, Raekil Park
Fenofibrate, an activator of peroxisome proliferator-activated receptors (PPARs), has been shown to protect the kidneys and brain cells from oxidative stress; however, its role in preventing hearing loss has not been reported to date, at least to the best of our knowledge. In this study, we demonstrated the protective effects of fenofibrate against gentamicin (GM)-induced ototoxicity. We found that the auditory brainstem response threshold which was increased by GM was significantly reduced by pre-treatment with fenofibrate in rats...
March 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28283951/relationships-between-element-contents-in-polish-children-s-and-adolescents-hair
#4
Maria Długaszek, Wojciech Skrzeczanowski
Environment, sex, and age are the main factors which determine the elemental composition of hair. The objective of the study is to determine the contents of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in girls' and boys' hair in five age groups (within 1-19-year range) corresponding to successive human ontogenesis phases as well as to evaluate the relationships between these elements. Quantitative analysis has been carried out using atomic absorption spectrometry (AAS)...
March 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28274810/non-clinical-safety-evaluation-and-risk-assessment-to-human-of-aleglitazar-a-dual-ppar-%C3%AE-%C3%AE-agonist-and-its-major-human-metabolite
#5
Martin Bopst, Elke-Astrid Atzpodien
The non-clinical safety profile of aleglitazar, a peroxisome proliferator activated receptor alpha/gamma agonist, and its major human metabolite M6 was studied in a complete package consisting of drug metabolism and pharmacokinetics characterization, safety pharmacology, genotoxicity, repeat dose toxicity, reproductive toxicity and carcinogenicity studies. These studies identified the following main targets similar to other PPAR agonists: red blood cell parameters, liver, heart, kidney, ovaries, testes, bone marrow, adipose tissue, and fluid accumulation...
March 6, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28257948/cadmium-induced-changes-in-vacuolar-aspects-of-arabidopsis-thaliana
#6
Shanti S Sharma, Kotaro Yamamoto, Kohei Hamaji, Miwa Ohnishi, Aya Anegawa, Shashi Sharma, Sveta Thakur, Vijay Kumar, Tomohiro Uemura, Akihiko Nakano, Tetsuro Mimura
We have examined the changes due to Cd treatment in the vacuolar form in root tip cortical cells in Arabidopsis thaliana employing a transformant with GFP fused to a tonoplast protein. A Cd-induced enhancement in complexity with general expansion of vacuolar system within 24 h was evident. The changes in the vacuolar form were dependent on the applied Cd concentrations. Concomitantly, as revealed through dithizone staining, Cd accumulated in the seedling roots exhibiting abundance of Cd-dithizone complexes in root tip, root hairs and vasculature...
February 23, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28257910/biomonitoring-of-toxic-metals-in-incinerator-workers-a-systematic-review
#7
Maria Chiara Mauriello, Carmine Sbordone, Paolo Montuori, Rossella Alfano, Maria Triassi, Ivo Iavicoli, Maurizio Manno
Exposure to chemicals released during urban waste disposal and treatment is increasingly regarded as a potential occupational health issue. Indeed, several toxic metals emitted by an incinerator, including As, Be, Cd, Cr, Pb, Mn, Hg, Ni and V, have potentially toxic properties and their exposure, therefore, may be of concern for the health of the workers involved. The levels of exposure should therefore be carefully measured. Environmental monitoring, however, may be unable, alone, to assess true exposure, due to its intrinsic limitations mainly concerning its inability to assess oral and dermal absorption...
March 1, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28250894/alcoholic-extract-of-eclipta-alba-shows-in-vitro-antioxidant-and-anticancer-activity-without-exhibiting-toxicological-effects
#8
Navneet Kumar Yadav, Rakesh Kumar Arya, Kapil Dev, Chetan Sharma, Zakir Hossain, Sanjeev Meena, K R Arya, J R Gayen, Dipak Datta, R K Singh
As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28243487/diet-and-hair-loss-effects-of-nutrient-deficiency-and-supplement-use
#9
Emily L Guo, Rajani Katta
Patients presenting with hair loss should be screened by medical history, dietary history and physical exam for risk factors for nutrient deficiency. If warranted, laboratory studies may be performed. In patients with no risk factors, further laboratory evaluation searching for nutritional deficiencies is not warranted. For patients with nutritional deficiencies, it is clear that those deficiencies should be corrected. Further research is required to determine whether any benefit exists for nutrient supplementation in the absence of documented deficiency...
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28237569/preparation-and-characterization-of-novel-super-artificial-hair-fiber-based-on-biomass-materials
#10
Lijun Yang, Jing Guo, Sen Zhang, Yumei Gong
A novel super-artificial hair fiber basing on sodium alginate (SA) and Antarctic Krill protein (AKP) was prepared by wet spinning successfully. Such SA/AKP fiber did not only have similar crystalline structure with human hair, but also had super flame resistance and mechanical performance. It should be noted that the whole preparation process was green without any incorporation of non-toxic solution. Moreover, comparing with human hair, the SA/AKP fiber had a lot of unique groove upon the fiber surface, which contributed a lot to excellent hygroscopicity...
February 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28223157/dose-dependent-cochlear-and-vestibular-toxicity-of-trans-tympanic-cisplatin-in-the-rat
#11
Angela Callejo, Amandine Durochat, Stéphanie Bressieux, Aurélie Saleur, Christian Chabbert, Ivan Domènech Juan, Jordi Llorens, Sophie Gaboyard-Niay
In vivo studies are needed to study cisplatin ototoxicity and to evaluate candidate protective treatments. Rats and mice are the preferred species for toxicological and pharmacological pre-clinical research, but systemic administration of cisplatin causes high morbidity in these species. We hypothesized that trans-tympanic administration of cisplatin would provide a good model for studying its auditory and vestibular toxicity in the rat. Cisplatin was administered by the trans-tympanic route in one ear (50μl, 0...
February 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28202726/two-tonoplast-mate-proteins-function-as-turgor-regulating-chloride-channels-in-arabidopsis
#12
Haiwen Zhang, Fu-Geng Zhao, Ren-Jie Tang, Yuexuan Yu, Jiali Song, Yuan Wang, Legong Li, Sheng Luan
The central vacuole in a plant cell occupies the majority of the cellular volume and plays a key role in turgor regulation. The vacuolar membrane (tonoplast) contains a large number of transporters that mediate fluxes of solutes and water, thereby adjusting cell turgor in response to developmental and environmental signals. We report that two tonoplast Detoxification efflux carrier (DTX)/Multidrug and Toxic Compound Extrusion (MATE) transporters, DTX33 and DTX35, function as chloride channels essential for turgor regulation in Arabidopsis Ectopic expression of each transporter in Nicotiana benthamiana mesophyll cells elicited a large voltage-dependent inward chloride current across the tonoplast, showing that DTX33 and DTX35 each constitute a functional channel...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28199947/environmental-biomonitoring-of-essential-and-toxic-elements-in-human-scalp-hair-using-accelerated-microwave-assisted-sample-digestion-and-inductively-coupled-plasma-optical-emission-spectroscopy
#13
Hope Kumakli, A'ja V Duncan, Kiara McDaniel, Tsdale F Mehari, Jamira Stephenson, Lareisha Maple, Zaria Crawford, Calvin L Macemore, Carol M Babyak, Sayo O Fakayode
Human scalp hair samples were collected and used to assess exposure to toxic elements and essential elements in the state of North Carolina, USA using accelerated microwave assisted acid digestion and inductively coupled plasma optical emission spectroscopy (ICP-OES). The figures-of-merit of the ICP-OES were appropriate for elemental analysis in scalp hair with detection limits as low as 0.0001 mg/L for Cd, good linearity (R(2) > 0.9978), and percent recoveries that ranged from 96 to 106% for laboratory-fortified-blanks and 88-112% for sample spike recovery study...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28174041/occurrence-origin-and-toxicity-of-disinfection-byproducts-in-chlorinated-swimming-pools-an-overview
#14
REVIEW
Tarek Manasfi, Bruno Coulomb, Jean-Luc Boudenne
Disinfection treatments are critical to conserve the microbiological quality of swimming pool water and to prevent water-borne infections. The formation of disinfection byproducts (DBPs) in swimming pools is an undesirable consequence resulting from reactions of disinfectants (e.g. chlorine) with organic and inorganic matter present in pool water, mainly brought by bathers. A considerable body of occurrence studies has identified several classes of DBPs in swimming pools with more than 100 compounds detected, mainly in chlorinated freshwater pools...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28163078/manganese-superoxide-dismutase-influences-the-extent-of-noise-induced-hearing-loss-in-mice
#15
Ayinuer Tuerdi, Makoto Kinoshita, Teru Kamogashira, Chisato Fujimoto, Shinnichi Iwasaki, Takahiko Shimizu, Tatsuya Yamasoba
Reactive oxygen species (ROS) generation is one of the mechanisms underlying noise-induced hearing loss (NIHL). Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme acting within the mitochondria, converts toxic superoxide to hydrogen peroxide. We investigated the role of Mn-SOD in NIHL by examining the extent of hearing loss and hair cell damage after noise exposure in C57BL/6 wild-type (WT) mice and Mn-SOD heterozygous knockout (HET) mice (n=6 each). Both HET and WT mice were exposed to 120dB sound pressure level at 4kHz octave band noise for 4h...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28134037/destiny-rides-again-the-reappearance-of-silicone-gel-filled-breast-implant-toxicity
#16
A E Brawer
Background Twenty-five years ago attorneys representing ailing women in class action litigation against silicone breast implant manufacturers made the procedural error of defining silicone-induced toxicity in the courtroom before it was properly studied in the exam room. This aberrant methodology perverted the proper research process, rendered verification of any real disease elusive, and cemented the groundwork for a repeat public health crisis potentially affecting two million women in the USA who possess new silicone gel devices inserted over the past 10 years...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28111002/more-surprises-in-the-global-greenhouse-human-health-impacts-from-recent-toxic-marine-aerosol-formations-due-to-centennial-alterations-of-world-wide-coastal-food-webs
#17
REVIEW
J J Walsh, J M Lenes, R H Weisberg, L Zheng, C Hu, K A Fanning, R Snyder, J Smith
Reductions of zooplankton biomasses and grazing pressures were observed during overfishing-induced trophic cascades and concurrent oil spills at global scales. Recent phytoplankton increments followed, once Fe-, P-, and N-nutrient limitations of commensal diazotrophs and dinoflagellates were also eliminated by respective human desertification, deforestation, and eutrophication during climate changes. Si-limitation of diatoms instead ensued during these last anthropogenic perturbations of agricultural effluents and sewage loadings...
January 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28108668/ultraviolet-and-yellow-reflectance-but-not-fluorescence-is-important-for-visual-discrimination-of-conspecifics-by-heliconius-erato
#18
Susan D Finkbeiner, Dmitry A Fishman, Daniel Osorio, Adriana D Briscoe
Toxic Heliconius butterflies have yellow hindwing bars that - unlike their closest relatives - reflect ultraviolet (UV) and long wavelength light, and also fluoresce. The pigment in the yellow scales is 3-hydroxy-DL-kynurenine (3-OHK), found also in the hair and scales of a variety of animals. In other butterflies like pierids with color schemes characterized by independent sources of variation in UV and human-visible yellow/orange, behavioral experiments have generally implicated the UV component as most relevant to mate choice...
January 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28103938/the-gastro-protective-effects-of-cibotium-barometz-hair-on-ethanol-induced-gastric-ulcer-in-sprague-dawley-rats
#19
Nahla Saeed Al-Wajeeh, Maryam Hajerezaie, Suzita Mohd Noor, Mohammed Farouq Halabi, Nawal Al-Henhena, Ainnul Hamidah Syahadah Azizan, Sareh Kamran, Pouya Hassandarvish, Abdrabuh N Shwter, Hamed Karimian, Hapipah Mohd Ali, Mahmood Ameen Abdulla
BACKGROUND: Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer effects of C. barometz hair on ethanol-induced stomach hemorrhagic abrasions in animals. Seven groups of Sprague Dawley (SD) rats were administered 10% Tween 20 in the normal control and ulcer control groups, and omeprazole 20 mg/kg and 62.5, 125, 250, and 500 mg/kg of C. barometz hair extract in the experimental groups...
January 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28093694/comparative-analysis-on-the-effect-of-plantago-species-aqueous-extracts-on-tissue-trace-element-content-in-rats
#20
Evgenia R Gatiatulina, Olga N Nemereshina, Joanna Suliburska, Tejo Prakash Nagaraja, Anastasia A Skalnaya, Alexandr A Nikonorov, Anatoly V Skalny, Alexey A Tinkov
The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry...
January 16, 2017: Biological Trace Element Research
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