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https://www.readbyqxmd.com/read/29163159/larvicidal-histopathological-efficacy-of-penicillium-daleae-against-larvae-of-culex-quinquefasciatus-and-aedes-aegypti-plus-biotoxicity-on-artemia-nauplii-a-non-target-aquatic-organism
#1
C Ragavendran, T Mariappan, Devarajan Natarajan
Mosquitoes can transmit the terrible diseases to human beings. Soil-borne fungal products act as potential source for low-cost chemicals, used for developing eco-friendly control agents against mosquito-vector borne diseases. The prime aim of study was to check the larvicidal potential of fungus mycelia (by ethyl acetate solvent) extract from Penicillium daleae (KX387370) against Culex quinquefasciatus and Aedes aegypti and to test the toxicity of brine shrimp Artemia nauplii, by observing the physiological activity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29160686/human-hair-keratin-for-biocompatible-flexible-and-transient-electronic-devices
#2
Jieun Ko, Luong Thi Hieun Nguyen, Abhijith Surendran, Bee Yi Tan, Kee Woei Ng, Wei Lin Leong
Biomaterials have been attracting attention as a useful building block for biocompatible and bioresorbable electronics due to its non-toxic property and solution processabillity. In this work, we report the integration of biocompatible keratin from human hair as dielectric layer for organic thin-film transistors (TFTs), with high performance, flexibility and transient property. The keratin dielectric layer exhibited a high capacitance value above 1.27 μF/cm2 at 20 Hz due to the formation of electrical double layer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29156601/acute-toxicity-and-ecological-risk-assessment-of-benzophenone-3-bp-3-and-benzophenone-4-bp-4-in-ultraviolet-uv-filters
#3
Yang Du, Wen-Qian Wang, Zhou-Tao Pei, Fahmi Ahmad, Rou-Rou Xu, Yi-Min Zhang, Li-Wei Sun
Ultraviolet (UV)-absorbing chemicals (UV filters) are used in personal care products for the protection of human skin and hair from damage by UV radiation. Although these substances are released into the environment in the production and consumption processes, little is known about their ecotoxicology effects. The acute toxicity and potential ecological risk of UV filters benzophenone-3 (BP-3) and benzophenone-4 (BP-4) on Chlorella vulgaris, Daphnia magna, and Brachydanio rerio were analyzed in the present study...
November 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156328/role-of-hair-pigmentation-in-drug-incorporation-into-hair
#4
Hyerim Yu, Won-Jun Jang, Jung-Hee Jang, Byoungduck Park, Young Ho Seo, Chul-Ho Jeong, Sooyeun Lee
Hair analysis has notably expanded its application as a bio-monitor for drug or toxicant exposure. Hair pigmentation is proposed as a major factor affecting drug incorporation into hair; however, the mechanisms underlying the incorporation of drugs into hair are still unclear. In the present study, the effect of hair pigmentation on drug incorporation into hair was examined using rats carrying hair with different melanin status and human cells (SK-Mel-28 cells, HaCaT cells and the co-cultured HaCaT cells with SK-Mel-28 cells) representing the main pigmentary unit in hair...
November 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29154796/treatment-of-cancer-by-low-intensity-laser-radiation-therapy
#5
REVIEW
Sahar E Abo-Neima
Cancer treatment is one of the main challenges that face the scientific centers all over the world. The cancer incidence percentage increases year after year. The most used treatment for cancer is chemotherapy which is an application of systemic cytotoxic drug inside the patient. There are two main problems in chemotherapy that the cytotoxic drug is given systematically and cannot be localized in the tumor region in most cases that lead to killing the cancer cells as well as normal cells; and that cause the chemotherapy side effects like anemia, decrease in all blood cells count and platelets, nausea, vomiting, diarrhea, hair and nails loss and may cause a kind of blood toxicity...
November 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29151127/permeability-of-hair-to-cadmium-copper-and-lead-in-five-species-of-terrestrial-mammals-and-implications-in-biomonitoring
#6
A N Rendón-Lugo, P Santiago, I Puente-Lee, L León-Paniagua
The capacity of mammal hair to absorb toxic metals and its utility in biomonitoring has been broadly studied. Though these metal-binding properties has generally been attributed to the sulphur contained in cysteine, an amino acid that forms part of keratin, there are not many experimental studies that analyze the role of sulphur in the external deposition of potentially toxic metallic elements in order to better understand the potential of hair in biomonitoring and generate better tools for differentiating between internal and external deposition of contaminants...
November 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29145616/variation-in-methylmercury-metabolism-and-elimination-status-mermes-in-humans-following-fish-consumption
#7
Samuel W Caito, Brian P Jackson, Tracy Punshon, Thomas Scrimale, Alex Grier, Steven R Gill, Tanzy M Love, Gene E Watson, Edwin van Wijngaarden, Matthew D Rand
Evaluating the potential for methylmercury (MeHg) toxicity relies on accurately predicting the mercury (Hg) body burden that results from eating fish. Hg body burden is directly determined by the slow elimination kinetics of MeHg in the human body (kel ∼0.014days-1 or t1/2∼ 50days). Existing studies on MeHg half-life in humans demonstrate a wide range values (t1/2 = 30 to > 150days) and has lead to uncertainty in the derivation of a regulatory standard for acceptable daily oral intake. The causes of variation in MeHg toxicokinetics in humans remain little explored...
November 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29145270/study-on-the-adverse-effects-following-chemotherapy-for-breast-cancer-diagnosis-during-pregnancy-the-first-case-report-in-china
#8
Xin Ye, Qi He, Xiaoyun Zhou
RATIONALE: Treatment of breast cancer during pregnancy (BCP) remains a challenge to physicians. Surgery and chemotherapy during pregnancy are widely used for the treatment of BCP. Herein, we reported 3 Chinese patients with BCP who underwent chemotherapy during pregnancy and were followed up for adverse effects. PATIENT CONCERNS: Three female patients (case 1, case 2, and case 3) of 37-, 32-, and 28-year-old with breast masses were enrolled. Case 1 had been pregnant for over 4 months, case 2 over 7 months, and case 3 for 7 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29131041/skin-manifestations-of-targeted-antineoplastic-therapy
#9
Onofre Sanmartín
The management of oncology patients has changed significantly over recent years, with the development of new targeted anticancer therapies. Cutaneous adverse effects are among the most frequently observed toxicities with many targeted agents; their intensity can be dose-limiting or lead to the discontinuation of therapy. Tyrosine kinase inhibitors can cause maculopapular rash and hand-foot reaction, whereas papulopustular rash, paronychia, regulatory changes in hair, and dryness are caused by epidermal growth factor receptor inhibitors...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29130636/efficacy-of-subcutaneous-injection-of-platelet-rich-plasma-in-alopecia-a-clinical-and-histological-pilot-study-on-a-rat-model-with-a-six-month-long-term-follow-up-experience
#10
Sophie Orliac, Jean-Michel Serfaty, Anne Perozziello, Olivier Zurlinden, Liliane Louedec, Benjamin Dallaudière
PURPOSE: To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity. MATERIALS-METHODS: Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). We initiated subcutaneous injection using either PRP in PRPQ+, platelet-poor plasma (PPP) in PPPQ+, physiological serum (PS) in PSQ+, or no treatment (Q4). At D7, D14, D21, and D28 but also second month (M2), M3, M4, M5, rats had exactly the same injection procedure...
November 11, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29126482/identification-of-new-tetrahydroxylated-metabolites-of-polycyclic-aromatic-hydrocarbons-in-hair-as-biomarkers-of-exposure-and-signature-of-dna-adduct-levels
#11
Nathalie Grova, Jean-Philippe Antignac, Emilie M Hardy, Fabrice Monteau, Karine Pouponneau, Bruno Le Bizec, Brice M R Appenzeller
The present study addresses the hypothesis that the concentration of tetrahydroxylated Polycylic Aromatic Hydrocarbons (tetra-OH-PAHs) in hair might be a useful biomarker of human exposure to PAHs, providing quantitative assessment of the internal dose, as well as information on the associated toxicity in relation to individual's specific metabolism. By means of animal models, this work aimed at identifying new tetra-OH-PAHs which can be released from the hydrolysis of DNA-adducts and can also be directly detected in biological matrices usually used in the field of biomonitoring such as hair and urine...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29118527/unusual-pattern-of-whitening-of-eyebrows-following-sunitinib-therapy-a-case-report-with-brief-review-of-literature
#12
Chaturbhuj R Agrawal, Vineet Talwar, Venkata Pradeep Babu, Parveen Jain, Pankaj Goyal
Sunitinib is a vascular endothelial growth factor receptor inhibitor which has shown high activity in metastatic renal cell carcinoma (mRCC) patients and is now widely used for the same. It is generally well tolerated, but sometimes, it exhibits a distinct pattern of novel side effects that require monitoring and management. Important known side effect of sunitinib includes fatigue, diarrhea, anorexia, skin toxicity, and hypertension which need special mention. Considering its effectiveness in first-line setting in mRCC and paucity of other good options, utmost efforts are made to continue it with identification of side effects which may require only slight dose modification or no dose alteration...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29107366/correlations-between-hair-and-tissue-mercury-concentrations-in-icelandic-arctic-foxes-vulpes-lagopus
#13
Gabriele Treu, Oliver Krone, Ester Rut Unnsteinsdóttir, Alex D Greenwood, Gábor Á Czirják
Monitoring organic pollutants in wildlife is a common approach to evaluate environmental health, chemical exposure and to make hazard assessments. However, pollutant concentrations measured from different tissue types among studies impede direct comparisons of levels and toxicity benchmarks among species and regions. For example, mercury (Hg) is a metal of both natural and anthropogenic origin which poses health risks for marine and arctic biota in particular. Although hair is recognized as the least invasive sample type for Hg exposure measurement in wildlife, measurements in previous studies have used different tissues among individuals and species...
October 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29106930/topical-inhibition-of-the-electron-transport-chain-can-stimulate-the-hair-cycle
#14
M Miranda, H Christofk, D L Jones, W E Lowry
While many signaling pathways have been implicated in control of activation of adult hair follicle stem cells and the hair cycle, less is known about cell intrinsic mechanisms of stem cell control. We previously identified lactate production as a key cell intrinsic regulator of hair follicle stem cell activity, suggesting that cellular metabolism is important in stem cell activation. Others have used transgenic methods to suggest that transgenic blockade of the Electron Transport Chain (ETC) leads to degeneration of the hair follicle...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29094220/ibrutinib-associated-nail-plate-abnormalities-case-reports-and-review
#15
Lucas A Heldt Manica, Philip R Cohen
Chronic lymphocytic leukemia is a lymphoproliferative disorder characterized by a gradual accumulation of neoplastic B-lymphocytes. Ibrutinib is a novel therapy for chronic lymphocytic leukemia. Ibrutinib therapy has been associated with nail plate abnormalities. Other common cutaneous adverse events caused by ibrutinib appear to be bruising, hair changes, pruritus, and rashes. We describe the clinical features of two patients with chronic lymphocytic leukemia: a 79-year-old woman and a 53-year-old man who developed nail plate abnormalities approximately 6 and 4 months, respectively, after beginning ibrutinib therapy...
November 1, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29093665/pi3k-and-inhibitor-of-apoptosis-proteins-modulate-gentamicin-induced-hair-cell-death-in-the-zebrafish-lateral-line
#16
Heather Wiedenhoft, Lauren Hayashi, Allison B Coffin
Inner ear hair cell death leads to sensorineural hearing loss and can be a direct consequence of aminoglycoside antibiotic treatment. Aminoglycosides such as gentamicin are effective therapy for serious Gram-negative bacterial infections such as some forms of meningitis, pneumonia, and sepsis. Aminoglycosides enter hair cells through mechanotransduction channels at the apical end of hair bundles and initiate intrinsic cell death cascades, but the precise cell signaling that leads to hair cell death is incompletely understood...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29081812/peptide-inhibitor-of-complement-c1-inhibits-the-peroxidase-activity-of-hemoglobin-and-myoglobin
#17
Pamela S Hair, Kenji M Cunnion, Neel K Krishna
Hemoglobin is the natural carrier of oxygen in red blood cells (RBCs). While intracellular hemoglobin provides life-sustaining oxygen transport, extracellular free hemoglobin displays toxicity due to inherent peroxidase activity generating reactive oxygen species that subsequently react with the hemoglobin molecule to produce toxic heme degradation products resulting in free radicals, oxidative stress damage, and lipid peroxidation. We have recently demonstrated that Peptide Inhibitor of Complement C1 (PIC1) inhibits peroxidase activity of the heme-based enzyme myeloperoxidase...
2017: International Journal of Peptides
https://www.readbyqxmd.com/read/29078194/desorption-of-sulphur-mustard-simulants-methyl-salicylate-and-2-chloroethyl-ethyl-sulphide-from-contaminated-scalp-hair-after-vapour-exposure
#18
Marie Spiandore, Mélanie Souilah-Edib, Anne Piram, Alexandre Lacoste, Denis Josse, Pierre Doumenq
Chemical warfare agents have been used to incapacitate, injure or kill people, in a context of war or terrorist attack. It has previously been shown that hair could trap the sulphur mustard simulants methyl salicylate and 2-chloroethyl ethyl sulphide. In order to investigate simulants persistency in hair after intense vapour exposure, their desorption kinetics were studied by using two complementary methods: hair residual content measurement and desorbed vapour monitoring. Results showed that both simulants were detected in air and could be recovered from hair 2 h after the end of exposure...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29073515/high-risk-of-misinterpreting-hair-analysis-results-for-children-tested-for-methadone
#19
Pascal Kintz, Audrey Farrugia, Alice Ameline, Aude Eibel, Jean-Sébastien Raul
The major problem after testing the hair of a child for drugs is the interpretation of the findings. In 2016, the laboratory received several hair specimens with the request to verify if there was any evidence of previous methadone exposure by the donor of the sample. Case 1 was a child admitted to the Emergency Unit for intense sedation and breathing difficulties. Cases 2-4 involved children found dead at home. In all cases, methadone and EDDP, its metabolite, were found in blood. After decontamination, the hair was analysed with LC-MS/MS for methadone and EDDP...
November 2017: Forensic Science International
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#20
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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