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https://www.readbyqxmd.com/read/28202726/two-tonoplast-mate-proteins-function-as-turgor-regulating-chloride-channels-in-arabidopsis
#1
Haiwen Zhang, Fu-Geng Zhao, Ren-Jie Tang, Yuexuan Yu, Jiali Song, Yuan Wang, Legong Li, Sheng Luan
The central vacuole in a plant cell occupies the majority of the cellular volume and plays a key role in turgor regulation. The vacuolar membrane (tonoplast) contains a large number of transporters that mediate fluxes of solutes and water, thereby adjusting cell turgor in response to developmental and environmental signals. We report that two tonoplast Detoxification efflux carrier (DTX)/Multidrug and Toxic Compound Extrusion (MATE) transporters, DTX33 and DTX35, function as chloride channels essential for turgor regulation in Arabidopsis Ectopic expression of each transporter in Nicotiana benthamiana mesophyll cells elicited a large voltage-dependent inward chloride current across the tonoplast, showing that DTX33 and DTX35 each constitute a functional channel...
February 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28199947/environmental-biomonitoring-of-essential-and-toxic-elements-in-human-scalp-hair-using-accelerated-microwave-assisted-sample-digestion-and-inductively-coupled-plasma-optical-emission-spectroscopy
#2
Hope Kumakli, A'ja V Duncan, Kiara McDaniel, Tsdale F Mehari, Jamira Stephenson, Lareisha Maple, Zaria Crawford, Calvin L Macemore, Carol M Babyak, Sayo O Fakayode
Human scalp hair samples were collected and used to assess exposure to toxic elements and essential elements in the state of North Carolina, USA using accelerated microwave assisted acid digestion and inductively coupled plasma optical emission spectroscopy (ICP-OES). The figures-of-merit of the ICP-OES were appropriate for elemental analysis in scalp hair with detection limits as low as 0.0001 mg/L for Cd, good linearity (R(2) > 0.9978), and percent recoveries that ranged from 96 to 106% for laboratory-fortified-blanks and 88-112% for sample spike recovery study...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28174041/occurrence-origin-and-toxicity-of-disinfection-byproducts-in-chlorinated-swimming-pools-an-overview
#3
REVIEW
Tarek Manasfi, Bruno Coulomb, Jean-Luc Boudenne
Disinfection treatments are critical to conserve the microbiological quality of swimming pool water and to prevent water-borne infections. The formation of disinfection byproducts (DBPs) in swimming pools is an undesirable consequence resulting from reactions of disinfectants (e.g. chlorine) with organic and inorganic matter present in pool water, mainly brought by bathers. A considerable body of occurrence studies has identified several classes of DBPs in swimming pools with more than 100 compounds detected, mainly in chlorinated freshwater pools...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28163078/manganese-superoxide-dismutase-influences-the-extent-of-noise-induced-hearing-loss-in-mice
#4
Ayinuer Tuerdi, Makoto Kinoshita, Teru Kamogashira, Chisato Fujimoto, Shinnichi Iwasaki, Takahiko Shimizu, Tatsuya Yamasoba
Reactive oxygen species (ROS) generation is one of the mechanisms underlying noise-induced hearing loss (NIHL). Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme acting within the mitochondria, converts toxic superoxide to hydrogen peroxide. We investigated the role of Mn-SOD in NIHL by examining the extent of hearing loss and hair cell damage after noise exposure in C57BL/6 wild-type (WT) mice and Mn-SOD heterozygous knockout (HET) mice (n=6 each). Both HET and WT mice were exposed to 120dB sound pressure level at 4kHz octave band noise for 4h...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28134037/destiny-rides-again-the-reappearance-of-silicone-gel-filled-breast-implant-toxicity
#5
A E Brawer
Background Twenty-five years ago attorneys representing ailing women in class action litigation against silicone breast implant manufacturers made the procedural error of defining silicone-induced toxicity in the courtroom before it was properly studied in the exam room. This aberrant methodology perverted the proper research process, rendered verification of any real disease elusive, and cemented the groundwork for a repeat public health crisis potentially affecting two million women in the USA who possess new silicone gel devices inserted over the past 10 years...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28111002/more-surprises-in-the-global-greenhouse-human-health-impacts-from-recent-toxic-marine-aerosol-formations-due-to-centennial-alterations-of-world-wide-coastal-food-webs
#6
REVIEW
J J Walsh, J M Lenes, R H Weisberg, L Zheng, C Hu, K A Fanning, R Snyder, J Smith
Reductions of zooplankton biomasses and grazing pressures were observed during overfishing-induced trophic cascades and concurrent oil spills at global scales. Recent phytoplankton increments followed, once Fe-, P-, and N-nutrient limitations of commensal diazotrophs and dinoflagellates were also eliminated by respective human desertification, deforestation, and eutrophication during climate changes. Si-limitation of diatoms instead ensued during these last anthropogenic perturbations of agricultural effluents and sewage loadings...
January 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28108668/ultraviolet-and-yellow-reflectance-but-not-fluorescence-is-important-for-visual-discrimination-of-conspecifics-by-heliconius-erato
#7
Susan D Finkbeiner, Dmitry A Fishman, Daniel Osorio, Adriana D Briscoe
Toxic Heliconius butterflies have yellow hindwing bars that - unlike their closest relatives - reflect ultraviolet (UV) and long wavelength light, and also fluoresce. The pigment in the yellow scales is 3-hydroxy-DL-kynurenine (3-OHK), found also in the hair and scales of a variety of animals. In other butterflies like pierids with color schemes characterized by independent sources of variation in UV and human-visible yellow/orange, behavioral experiments have generally implicated the UV component as most relevant to mate choice...
January 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28103938/the-gastro-protective-effects-of-cibotium-barometz-hair-on-ethanol-induced-gastric-ulcer-in-sprague-dawley-rats
#8
Nahla Saeed Al-Wajeeh, Maryam Hajerezaie, Suzita Mohd Noor, Mohammed Farouq Halabi, Nawal Al-Henhena, Ainnul Hamidah Syahadah Azizan, Sareh Kamran, Pouya Hassandarvish, Abdrabuh N Shwter, Hamed Karimian, Hapipah Mohd Ali, Mahmood Ameen Abdulla
BACKGROUND: Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer effects of C. barometz hair on ethanol-induced stomach hemorrhagic abrasions in animals. Seven groups of Sprague Dawley (SD) rats were administered 10% Tween 20 in the normal control and ulcer control groups, and omeprazole 20 mg/kg and 62.5, 125, 250, and 500 mg/kg of C. barometz hair extract in the experimental groups...
January 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28093694/comparative-analysis-on-the-effect-of-plantago-species-aqueous-extracts-on-tissue-trace-element-content-in-rats
#9
Evgenia R Gatiatulina, Olga N Nemereshina, Joanna Suliburska, Tejo Prakash Nagaraja, Anastasia A Skalnaya, Alexandr A Nikonorov, Anatoly V Skalny, Alexey A Tinkov
The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry...
January 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28069428/high-concentrations-of-lead-and-barium-in-hair-of-the-rural-population-caused-by-water-pollution-in-the-thar-jath-oilfields-in-south-sudan
#10
Fritz Pragst, Klaus Stieglitz, Hella Runge, Klaus-Dietrich Runow, David Quig, Robert Osborne, Christian Runge, John Ariki
In the oil fields of Thar Jath, South Sudan, increasing salinity of drinking water was observed together with human incompatibilities and rise in livestock mortalities. Hair analysis was used to characterize the toxic exposure of the population. Hair samples of volunteers from four communities with different distance from the center of the oil field (Koch 23km, n=24; Leer 50km, n=26; Nyal 110km, n=21; and Rumbek 220km, n=25) were analyzed for altogether 39 elements by inductively coupled plasma-mass spectrometry...
December 23, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28049063/activity-of-pericampylus-glaucus-and-periglaucine-a-in-vitro-against-nasopharangeal-carcinoma-and-anti-inflammatory-activity
#11
Fiona Natalia Shipton, Teng-Jin Khoo, Md Shahadat Hossan, Christophe Wiart
ETHNOPHARMACOLOGICAL RELEVANCE: P. glaucus is a climbing plant found across Asia and used in traditional medicine to treat a number of conditions including splenomegaly, fever, cough, laryngitis, pulmonary disease, asthma, headache, hair loss, snake bite, boar bite, factures, boils, tumours, tetanus, rheumatic pain, itches and eclampsia. AIM OF THE STUDY: To test extracts of P. glaucus in a number of bioassays and determine the legitimacy of its traditional use...
December 31, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28046145/effects-of-cows-grazing-toxic-endophyte-infected-tall-fescue-or-novel-endophyte-infected-tall-fescue-in-late-gestation-on-cow-performance-reproduction-and-progeny-growth-performance-and-carcass-characteristics
#12
L M Shoup, L M Miller, M Srinivasan, F A Ireland, D W Shike
Very little is known regarding the effects of cow exposure to toxic ergot alkaloids in late gestation and the subsequent, long-term effects on progeny. Therefore, the objectives were to determine the effects of grazing toxic endophyte-infected tall fescue () or novel endophyte-infected tall fescue during late gestation on cow BW, BCS, hair coat score (HCS), respiration rates, milk production, and reproduction and on growth performance and carcass characteristics of progeny. Eighty gestating, Angus × Simmental cows (age = 6...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28035605/the-level-of-toxic-and-essential-trace-elements-in-hair-of-petrochemical-workers-involved-in-different-technological-processes
#13
Anatoly V Skalny, Galina A Kaminskaya, Tatyana I Krekesheva, Sholpan K Abikenova, Margarita G Skalnaya, Elena S Berezkina, Andrei R Grabeklis, Alexey A Tinkov
The objective of the investigation is comparative analysis of hair trace element content in workers of different departments of petrochemical plant. A total of 75 men working in office (engineers), and departments 1 (D1), 3 (D3), and 4 (D4) of the petrochemical plant, as well as occupationally non-exposed persons, were examined. Hair trace element levels were analyzed using inductively coupled plasma mass spectrometry. The office workers were characterized by the highest hair As, Hg, Sn, I, and Si content as compared to the workers of other departments, whereas the level of those elements did not differ significantly from the control values...
December 29, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28024579/keratose-poly-vinyl-alcohol-blended-nanofibers-fabrication-and-biocompatibility-assessment
#14
Ju Wang, Shilei Hao, Tiantian Luo, Tao Zhou, Xin Yang, Bochu Wang
Increasing interest in using keratin-based materials for biomedical application has prompted the development of keratin/PVA nanofibers. To date, several kinds of keratins (including wool, feather, and human hair reductive keratins)/PVA blended nanofibers have been fabricated but limited to the in vitro studies. However, few studies focused on the in vivo biocompatibility test of keratin/PVA nanofibers. Herein, the keratose (oxidative keratin)/PVA nanofiber, a novel type of keratin/PVA nanofiber, was fabricated with an electrospinning technique...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28013217/strain-and-sex-differences-in-the-vestibular-and-systemic-toxicity-of-3-3-iminodipropionitrile-in-mice
#15
Pere Boadas-Vaello, Lara Sedó-Cabezón, Enrique Verdú, Jordi Llorens
The nitrile 3,3'-iminodipropionitrile (IDPN) causes a loss of hair cells in the vestibular epithelium of the inner ear in several species of both mammals and nonmammals. It is of interest as a model compound in ototoxicity and vestibular regeneration research, but its effects on the mouse, including the potential relevance of strain and sex differences for susceptibility, have not yet been thoroughly characterized. In this study, we compared the vestibular toxicity of IDPN in dose-response studies (0, 8, 12, 16, and 24 mmol/kg IDPN p...
December 24, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28004652/cutaneous-changes-in-internal-malignancy-study-from-a-tertiary-care-center
#16
Iffat Hassan, Sumaya Zeerak, Sanaullah Kuchay, Safia Bashir, Yasmeen J Bhat, Syed Mubashir, Farhan Rasool, Gousia Sheikh, Peerzada Sajad
BACKGROUND: A wide variety of systemic diseases and internal malignancies have cutaneous manifestations. In the context of internal malignancy, many cutaneous changes are highly specific to the underlying malignancy, while other changes are nonspecific. Some changes are also due to the modalities employed in the treatment of malignancies. METHODS: Two hundred and fifty patients who were diagnosed with internal malignancy and who were attending the department of radiation oncology, were evaluated at the Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Government Medical College, Srinagar...
December 20, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27999217/a-survey-on-lifestyle-and-level-of-biomarkers-of-environmental-exposure-in-residents-in-civitavecchia-italy
#17
Carla Ancona, Lisa Bauleo, Giovanni Biscotti, Beatrice Bocca, Stefano Caimi, Fabio Cruciani, Sabrina Di Lorenzo, Morena Petrolati, Anna Pino, Giovanna Piras, Augusto Pizzabiocca, Silvia Rabbiosi, Flavia Ruggieri, Chelo Salatino, Alessandro Alimonti, Francesco Forastiere
BACKGROUND: The assessment of individual exposure to toxicants in industrially contaminated areas is difficult when multiple productions are active close to residential areas. Two thermoelectric power plants and a large harbor have been operating since the '60s in the area of Civitavecchia (North of Rome). METHODS: The ABC (Ambiente e Biomonitoraggio nell'area di Civitavecchia, Environment and Biomonitoring in Civitavecchia) program involved, in the period 2013-2014, residents in Civitavecchia and in the nearby municipalities (Santa Marinella, Allumiere, Tolfa and Tarquinia)...
October 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27997709/the-role-of-allogenic-keratin-derived-dressing-in-wound-healing-in-a-mouse-model
#18
Marek Konop, Dorota Sulejczak, Joanna Czuwara, Piotr Kosson, Aleksandra Misicka, Aandrzej W Lipkowski, Lidia Rudnicka
: Keratin is an interesting protein needed for wound healing and tissue recovery. We have recently proposed a new, simple and inexpensive method to obtain fur and hair keratin-derived biomaterials suitable for medical application. The aim of the study was to evaluate the role of the fur keratin derived protein (FKDP) dressing in the allogenic full-thickness surgical skin wound model. RESULTS: The data obtained using scanning electron microscopy showed that employed processed biomaterial had higher surface porosity compared to control raw material...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27991862/fluorescent-aminoglycosides-reveal-intracellular-trafficking-routes-in-mechanosensory-hair-cells
#19
Dale W Hailey, Robert Esterberg, Tor H Linbo, Edwin W Rubel, David W Raible
Aminoglycosides (AGs) are broad-spectrum antibiotics that are associated with kidney damage, balance disorders, and permanent hearing loss. This damage occurs primarily by killing of proximal tubule kidney cells and mechanosensory hair cells, though the mechanisms underlying cell death are not clear. Imaging molecules of interest in living cells can elucidate how molecules enter cells, traverse intracellular compartments, and interact with sites of activity. Here, we have imaged fluorescently labeled AGs in live zebrafish mechanosensory hair cells...
February 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27981612/cutaneous-reactions-in-children-treated-with-the-mitogen-activated-protein-kinase-extracellular-signal-regulated-kinase-inhibitor-trametinib-for-neural-tumors
#20
Christina Boull, Kristen Hook, Christopher Moertel, Sheilagh Maguiness
BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children. METHODS: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. All children were evaluated by a pediatric dermatologist with documentation of cutaneous findings...
January 2017: Pediatric Dermatology
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