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https://www.readbyqxmd.com/read/28444757/hypocobalaminaemia-as-a-cause-of-bone-marrow-failure-and-pancytopenia-in-a-cat
#1
E L Stanley, A E Eatroff
CASE REPORT: A male Domestic Short-hair cat was presented for chronic weight loss, lethargy and hyporexia. Complete haematological examination revealed non-regenerative anaemia, neutropenia and thrombocytopenia, as well as Howell-Jolly bodies, anisocytosis, polychromasia and macrocytosis on blood smear evaluation. Histopathological evaluation of bone marrow biopsy disclosed hypocellularity consistent with bone marrow failure. Concurrent hypocobalaminaemia was identified and treated with parenteral cyanocobalamin supplementation...
May 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28442873/anagen-effluvium-following-acute-colchicine-poisoning
#2
Andrea Combalia, Carola Baliu-Piqué, Adriana Fortea, Juan Ferrando
We present a case of a 17-year-old girl admitted to the Psychiatric Department recovering from a suicide attempt with colchicine. One week after poisoning, a sudden onset of hair loss was observed. Positive hair pull test and trichoscopy demonstrated the presence of anagen hairs with pigmented long roots covered by the root sheaths. Colchicine poisoning is an uncommon, but potentially life-threatening toxicologic emergency. An overdose of colchicine inhibits cell division, and thus the most affected organs are those which have a high rate of cell turnover...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28427959/beneficial-effects-of-heparin-and-l-arginine-on-dermonecrosis-effect-induced-by-vipera-lebetina-venom-involvement-of-no-in-skin-regeneration
#3
Nouara Bennacef-Heffar, Fatima Laraba-Djebari
It is well known that snake venoms such as Viperidae caused severe local effects such as hemorrhage, myonecrosis and dermonecrosis which can lead to permanent tissue loss or the disability. The aim of this study is to evaluate the skin regeneration using heparin and l-arginine as well as the dermonecrotic effects induced by Vipera lebetina venom (VLV). To better understand the toxic effects induced by VLV and to prevent or treat these effects, we evaluate the local effects and the skin regeneration with or without drugs...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28427493/hair-mercury-levels-and-their-relationship-with-seafood-consumption-among-preschool-children-in-shanghai
#4
Jin Yan, Zhen Yan Gao, Ju Wang, Chong Huai Yan
Mercury is a global pollutant. Children are vulnerable to environmental toxicants. Seafood consumption is a major source of methylmercury exposure. In order to ascertain children's mercury exposure levels and study their relationship with seafood consumption, we conducted a cross-sectional study among preschool children in Shanghai. According to our data, the geometric mean of the mercury levels in children's hair was 191.9 (95% CI: 181.8, 202.4) μg/kg. These results indicate that high income may be a predictor of elevated mercury levels in children's hair...
March 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28418431/body-burdens-sources-and-interrelations-of-selected-toxic-and-essential-elements-among-the-nine-cree-first-nations-of-eeyou-istchee-james-bay-region-of-northern-quebec-canada
#5
Evert Nieboer, Ian D Martin, Eric N Liberda, Eric Dewailly, Elizabeth Robinson, Leonard J S Tsuji
BACKGROUND: this article constitutes a report on the comprehensive Nituuchischaayihtitaau Aschii multi-community environment-and-health study conducted among the Cree peoples (Eeyouch) of northern Quebec, Canada. OBJECTIVES: to interpret observed concentrations of a suite of chemical elements in a multi-media biological monitoring study in terms of sources and predictors. METHODS: the concentrations of 5 essential and 6 toxic chemical elements were measured in whole blood, and/or in urine or hair by ICP-MS...
April 18, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28412580/a-non-toxic-dose-of-cobalt-chloride-blocks-hair-cells-of-the-zebrafish-lateral-line
#6
William J Stewart, Jacob L Johansen, James C Liao
Experiments on the flow-sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line hair cells and measure how behavior changes. Cobalt chloride (CoCl2) blocks the lateral line by inhibiting calcium movement through the membrane channels of hair cells, but high concentrations can be toxic, making it unclear whether changes in behavior are due to a blocked lateral line or poor health...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28412472/preparation-and-characterization-of-dutasteride-loaded-nanostructured-lipid-carriers-coated-with-stearic-acid-chitosan-oligomer-for-topical-delivery
#7
Norhayati Mohamed Noor, Khalid Sheikh, Satyanarayana Somavarapu, Kevin Mg Taylor
Dutasteride, used for treating benign prostate hyperplasia (BPH), promotes hair growth. To enhance delivery to the hair follicles and reduce systemic effects, in this study dutasteride has been formulated for topical application, in a nanostructured lipid carrier (NLC) coated with chitosan oligomer-stearic acid (CSO-SA). CSO-SA has been successfully synthesized, as confirmed using (1)H NMR and FTIR. Formulation of dutasteride-loaded nanostructured lipid carriers (DST-NLCs) was optimised using 2(3) full factorial design...
April 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28399085/-the-development-of-the-method-for-enzymatic-hydrolysis-for-the-extraction-of-toxic-substances-from-the-hair-samples
#8
Yu V Slustovskaya, M V Krys'ko, O Yu Strelova
The objective of the present study was to develop and validate the method for the extraction of toxic substances from the hair samples as exemplified by enzymatic hydrolysis of barbituric acid derivatives. The experiments were carried out with the use of laboratory animals (white female rats and albino guinea pigs) that had been daily given a phenobarbital solution per os during 4 months preceding the study. The hairs obtained from the experimental animals were subjected to acid hydrolysis with a 6 mole hydrochloric acid and enzymatic hydrolysis with the use of chymopsin, trypsin, chymotrypsin, and papain solutions...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28394490/synthesis-and-validation-of-functional-nanogels-as-ph-sensors-in-the-hair-follicle
#9
Mathias Dimde, Fitsum Feleke Sahle, Virginia Wycisk, Dirk Steinhilber, Luis Cuellar Camacho, Kai Licha, Jürgen Lademann, Rainer Haag
In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: ICC) and crosslinked via a mild and surfactant-free Thiol-Michael reaction using an inverse nanoprecipitation method. With this method, it is possible to prepare tailor-made particles in the range of 100 nm to 1 µm with a narrow polydispersity...
April 10, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28390615/protective-effects-of-1-2-3-triazole-derivative-kpr-a020-against-cisplatin-induced-ototoxicity-in-murine-cochlear-cultures
#10
Ye-Ri Kim, Da Jung Jung, Se-Kyung Oh, Taeho Lee, In-Kyu Lee, Kyu-Yup Lee, Un-Kyung Kim
Cisplatin (cis-diaminedichloridoplatinum(II), cis-[PtCl2(NH3)2]) is an effective chemotherapeutic agent in the treatment of several types of malignant solid tumors but its clinical use is associated with ototoxicity. Several studies have investigated the effect of antioxidants on cisplatin-induced ototoxicity in mice. The triazole KPR-A020 has been shown to play a protective role against mitochondrial dysfunction by reducing the production of mitochondrial reactive oxygen species (ROS). The effect of KPR-A020 on cisplatin-induced ototoxicity was examined using cultures of cochlear explants...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28390300/bisphenol-a-and-phthalates-in-utero-and-in-childhood-association-with-child-bmi-z-score-and-adiposity
#11
Tiffany C Yang, Karen E Peterson, John D Meeker, Brisa N Sánchez, Zhenzhen Zhang, Alejandra Cantoral, Maritsa Solano, Martha M Tellez-Rojo
OBJECTIVE: To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. METHODS: Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8-14 years...
April 5, 2017: Environmental Research
https://www.readbyqxmd.com/read/28384320/direct-administration-of-2-hydroxypropyl-beta-cyclodextrin-into-guinea-pig-cochleae-effects-on-physiological-and-histological-measurements
#12
J T Lichtenhan, K Hirose, C A Buchman, R K Duncan, A N Salt
2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheimer's disease, and atherosclerosis. But, a consequence is that HPβCD can cause hearing loss. HPβCD was recently found to be toxic to outer hair cells (OHCs) in the organ of Corti. Previous studies on the chronic effects of in vivo HPβCD toxicity did not know the intra-cochlear concentration of HPβCD and attributed variable effects on OHCs to indirect drug delivery to the cochlea. We studied the acute effects of known HPβCD concentrations administered directly into intact guinea pig cochleae...
2017: PloS One
https://www.readbyqxmd.com/read/28379072/biomarkers-of-mercury-toxicity-past-present-and-future-trends
#13
Vasco Branco, Sam Caito, Marcelo Farina, João Teixeira da Rocha, Michael Aschner, Cristina Carvalho
Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial compounds (methylmercury through fish, mercury vapor from dental amalgams, and ethylmercury from vaccines), the need for more sensitive and refined tools to assess the effects and/or susceptibility to adverse metal-mediated health risks remains. Traditional biomarkers, such as hair or blood Hg levels, are practical and provide a reliable measure of exposure, but given intra-population variability, it is difficult to establish accurate cause-effect relationships...
April 5, 2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28366956/study-of-arsenic-exposure-in-oral-oropharyngeal-carcinoma-in-west-bengal
#14
Pritha Pal, Ranjan Raychowdhury, Tuphan Kanti Dolai, Sanchita Roy, Rinini Dastidar, Ajanta Halder
OBJECTIVES: To study any possible correlation between arsenic toxicity and the development of oral carcinoma in West Bengal population. MATERIAL AND METHODS: Ethical clearance for this study was obtained from the Vivekananda Institute of Medical Sciences. Out of 30 785 patients attending our hospital from November 2012 to July 2015, 107 cases and 50 control individuals were selected. The hair and buccal smear samples were obtained upon their consent for the purpose of the analysis of arsenic count and cytogenetic damage, respectively...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28366955/signs-and-symptoms-of-mercury-exposed-gold-miners
#15
Stephan Bose-O'Reilly, Ludovic Bernaudat, Uwe Siebert, Gabriele Roider, Dennis Nowak, Gustav Drasch
OBJECTIVES: Gold miners use mercury to extract gold from ore adding liquid mercury to the milled gold-containing ore. This results in a mercury-gold compound, called amalgam. Miners smelt this amalgam to obtain gold, vaporizing it and finally inhaling the toxic mercury fumes. The objective was to merge and analyze data from different projects, to identify typical signs and symptoms of chronic inorganic mercury exposure. MATERIAL AND METHODS: Miners and community members from various artisanal small-scale gold mining areas had been examined (Philippines, Mongolia, Tanzania, Zimbabwe, Indonesia)...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28365236/the-assessment-of-the-chronic-hepatotoxicity-induced-by-polygoni-multiflori-radix-in-rats-a-pilot-study-by-using-untargeted-metabolomics-method
#16
Xin-Hua Xia, Yuan-Yuan Yuan, Mei Liu
Polygoni Multiflori Radix is the dried root of Polygonum multiflorum Thunb officially recorded in the Chinese Pharmacopoeia as HeShouWu (HSW) in Chinese pinyin. The processed HSW are commonly used in TCM to treat liver disease and Chinese Pharmacopoeia has described the actions of it to tonify liver-kidney, replenish essence and blood, blacken beard and hair, strengthen sinew and bone, and resolve turbidity and lower lipid hence making it use not only as a herbal medicine in TCM but also as supplementary food in health care...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28351555/taiwanese-dermatological-association-consensus-for-the-prevention-and-management-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-related-skin-toxicities
#17
Chia-Yu Chu, Kuan-Yu Chen, John Wen-Cheng Chang, Yu-Fong Wei, Chih-Hung Lee, Wei-Ming Wang
BACKGROUND/PURPOSE: This report describes the 2016 consensus of the Taiwanese Dermatological Association (TDA) regarding the definition, classification, diagnosis, prevention, and management of skin toxicities resulting from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This consensus is distributed to practices throughout Taiwan to provide recommendations for the diagnosis and treatment of such skin toxicities in order to improve the quality of life of patients undergoing EGFR-TKI treatment...
March 25, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28343039/study-of-trace-metal-imbalances-in-the-blood-scalp-hair-and-nails-of-oral-cancer-patients-from-pakistan
#18
Muhammad Abdul Qayyum, Munir H Shah
Oral cancer is an important cause of cancer morbidity and mortality globally and exposure to trace metals alongside tobacco, alcohol and HPV are the important etiological factors in its development. Selected essential and toxic trace metals (Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) were measured in the blood, scalp hair and nails of oral cancer patients and counterpart controls by atomic absorption spectrometry. Mean concentrations of Cd, Ni and Pb were found to be significantly higher (p<0.05) and those of Cu, Fe and Zn were considerably lower in the blood, scalp hair and nails of the patients than the controls...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28321398/unveiling-the-metabolic-changes-on-muscle-cell-metabolism-underlying-p-phenylenediamine-toxicity
#19
Igor Marín de Mas, Silvia Marín, Gisela Pachón, Juan C Rodríguez-Prados, Pedro Vizán, Josep J Centelles, Romà Tauler, Amaya Azqueta, Vitaly Selivanov, Adela López de Ceraín, Marta Cascante
Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase (CK) and myoglobulin, and is frequently accompanied by myoglobinuria. In the present work, we evaluated the toxicity of p-phenylenediamine (PPD), a main component of hair dyes which is reported to induce rhabdomyolysis. We studied the metabolic effect of this compound in vivo with Wistar rats and in vitro with C2C12 muscle cells...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28303511/macro-and-microelement-status-in-animal-and-human-hypertension-the-role-of-the-ace-gene-i-d-polymorphism
#20
Olena Pavlyushchik, Viktor Afonin, Svetlana Fatykhava, Polina Shabunya, Viktoryia Sarokina, Aliaksandr Khapaliuk
Genetic factors that predispose to hypertension may contribute to element disturbances observed in hypertensive patients. We tested the hypothesis that the deletion allele of the angiotensin-converting enzyme (ACE) gene is associated with element imbalances in hypertension. The concentrations of elements in genetically predisposed to hypertension rats (SHRs) and their controls (WKY rats) were also examined. ICP-MS was used for elemental analysis of human hair and animal fur. Genotyping was performed by PCR...
March 16, 2017: Biological Trace Element Research
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