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https://www.readbyqxmd.com/read/28643430/platinum-containing-regimens-for-metastatic-breast-cancer
#1
REVIEW
Sam J Egger, Melina L Willson, Jenna Morgan, Harriet S Walker, Sue Carrick, Davina Ghersi, Nicholas Wilcken
BACKGROUND: Studies have reported high tumour response rates for platinum-containing regimens in the treatment of women with metastatic breast cancer. Most of these studies were conducted prior to the 'intrinsic subtype' era, and did not specifically focus on metastatic triple-negative breast cancers (mTNBCs). OBJECTIVES: To identify and review the evidence from randomised trials comparing platinum-containing chemotherapy regimens with regimens not containing platinum in the management of women with metastatic breast cancer...
June 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28628971/occurrence-of-phthalate-diesters-in-indoor-air-from-several-northern-cities-in-vietnam-and-its-implication-for-human-exposure
#2
Tri Manh Tran, Hanh Thi Le, Tu Binh Minh, Kurunthachalam Kannan
Phthalates are used as plasticizers to impart flexibility of plastics. Because of their toxicity, human exposure to phthalates is a concern. Little is known on the occurrence of and inhalation exposure to phthalates in indoor air. In this study, ten phthalates were measured in 97 indoor air samples collected from Northern Vietnam during September 2016 to January 2017. The mean concentrations of total phthalates (i.e., sum of ten phthalates) in particulate and gas phases ranged from 95.2 to 13,100μgg(-1) and from 57...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28624929/latex-peptidases-of-calotropis-procera-for-dehairing-of-leather-as-an-alternative-to-environmentally-toxic-sodium-sulfide-treatment
#3
Laura M I Lopéz, Carolina A Viana, María E Errasti, María L Garro, José E Martegani, Germán A Mazzilli, Cléverson D T Freitas, Ídila M S Araújo, Rafaela O da Silva, Márcio V Ramos
Dehairing of crude leather is a critical stage performed at the beginning of its processing to obtain industrially useful pieces. Tanneries traditionally apply a chemical process based on sodium sulfide. Since this chemical reactive is environmentally toxic and inefficiently recycled, innovative protocols for reducing or eliminating its use in leather depilation are welcomed. Therefore, latex peptidases from Calotropis procera (CpLP) and Cryptostegia grandiflora (CgLP) were assayed for this purpose. Enzyme activity on substrates representative of skin such as hide powder azure (UHPA), elastin (UE), azocollagen (UAZOCOL), keratin (UK), and epidermis (UEP) was determined, while depilation activity was assayed on cow hide...
June 17, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28603488/hypothesis-of-k-recycling-defect-is-not-a-primary-deafness-mechanism-for-cx26-gjb2-deficiency
#4
REVIEW
Hong-Bo Zhao
K(+)-recycling defect is a long-standing hypothesis for deafness mechanism of Connexin26 (Cx26, GJB2) mutations, which cause the most common hereditary deafness and are responsible for >50% of nonsyndromic hearing loss. The hypothesis states that Cx26 deficiency may disrupt inner ear gap junctions and compromise sinking and recycling of expelled K(+) ions after hair cell excitation, causing accumulation of K(+)-ions in the extracellular space around hair cells producing K(+)-toxicity, which eventually induces hair cell degeneration and hearing loss...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28601996/risk-assessment-for-human-health-in-a-seleniferous-area-shuang-an-china
#5
Zewei Cui, Jie Huang, Qin Peng, Dasong Yu, Songshan Wang, Dongli Liang
Shuang'an in Ziyang is a typical high-selenium (Se) area in China, where human selenium (Se) poisoning was reported 30 years ago. To assess the risk of Se poisoning in the area, the Se content in agricultural soil, plant, and water in Naore, Shuang Hekou, and Lin Benhe villages of Ziyang was systematically investigated. The probable daily intake (PDI) was calculated on the basis of Se contents in food, water, and dietary habits to evaluate the risk of selenosis. Se content in hair from local habitants (32 men and 34 women) was determined to further verify the risk...
June 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28601433/characterization-of-xenobiotic-metabolizing-enzymes-of-a-reconstructed-human-epidermal-model-from-adult-hair-follicles
#6
Daniel Bacqueville, Carine Jacques, Laure Duprat, Emilien L Jamin, Beatrice Guiraud, Elisabeth Perdu, Sandrine Bessou-Touya, Daniel Zalko, Hélène Duplan
In this study, a comprehensive characterization of xenobiotic metabolizing enzymes (XMEs) based on gene expression and enzyme functionality was made in a reconstructed skin epidermal model derived from the outer root sheath (ORS) of hair follicles (ORS-RHE). The ORS-RHE model XME gene profile was consistent with native human skin. Cytochromes P450 (CYPs) consistently reported to be detected in native human skin were also present at the gene level in the ORS-RHE model. The highest Phase I XME gene expression levels were observed for alcohol/aldehyde dehydrogenases and (carboxyl) esterases...
June 7, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28577409/the-role-of-cadmium-in-obesity-and-diabetes
#7
REVIEW
Alexey A Tinkov, Tommaso Filippini, Olga P Ajsuvakova, Jan Aaseth, Yordanka G Gluhcheva, Juliana M Ivanova, Geir Bjørklund, Margarita G Skalnaya, Eugenia R Gatiatulina, Elizaveta V Popova, Olga N Nemereshina, Marco Vinceti, Anatoly V Skalny
Multiple studies have shown an association between environmental exposure to hazardous chemicals including toxic metals and obesity, diabetes, and metabolic syndrome. At the same time, the existing data on the impact of cadmium exposure on obesity and diabetes are contradictory. Therefore, the aim of the present work was to review the impact of cadmium exposure and status on the risk and potential etiologic mechanisms of obesity and diabetes. In addition, since an effect of cadmium exposure on incidence of diabetes mellitus and insulin resistance was suggested by several epidemiologic studies, we carried out a meta-analysis of all studies assessing risk of prevalence and incidence of diabetes...
May 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28576325/distinct-physiological-and-molecular-responses-in-arabidopsis-thaliana-exposed-to-aluminum-oxide-nanoparticles-and-ionic-aluminum
#8
Yujian Jin, Xiaoji Fan, Xingxing Li, Zhenyan Zhang, Liwei Sun, Zhengwei Fu, Michel Lavoie, Xiangliang Pan, Haifeng Qian
Nano-aluminium oxide (nAl2O3) is one of the most widely used nanomaterials. However, nAl2O3 toxicity mechanisms and potential beneficial effects on terrestrial plant physiology remain poorly understood. Such knowledge is essential for the development of robust nAl2O3 risk assessment. In this study, we studied the influence of a 10-d exposure to a total selected concentration of 98 μM nAl2O3 or to the equivalent molar concentration of ionic Al (AlCl3) (196 μM) on the model plant Arabidopsis thaliana on the physiology (e...
May 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28572727/organic-effects-of-associating-paclitaxel-with-a-lipid-based-nanoparticle-system-on-a-nonhuman-primate-cebus-apella
#9
Danielle Cristinne Azevedo Feio, Nayara Cristina Lima de Oliveira, Edmundo Luis Rodrigues Pereira, Aleksandra Tiemi Morikawa, José Augusto Pereira Carneiro Muniz, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Patrícia Danielle Lima de Lima, Raul Cavalcante Maranhão, Rommel Rodríguez Burbano
Lipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella, documenting the toxicity as measured by serum biochemistry, which is a detailed analysis of blood and tissue. Eighteen C. apella were studied: three animals were treated with cholesterol-rich nanoemulsion (LDE) only, without PTX, administered intravenously every 3 weeks, during six treatment cycles; six animals were treated with PTX associated with LDE at the same administration scheme, three with lower (175 mg/m(2)) and three with higher (250 mg/m(2)) PTX doses; and six animals were treated with commercial PTX, three with the lower and three with the higher doses...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28568705/hair-analysis-for-the-detection-of-drug-use-is-there-potential-for-evasion
#10
Shanna Marrinan, Andres Roman-Urrestarazu, Declan Naughton, Emerlinda Levari, John Collins, Robert Chilcott, Giuseppe Bersani, Ornella Corazza
BACKGROUND: Hair analysis for illicit substances is widely used to detect chronic drug consumption or abstention from drugs. Testees are increasingly seeking ways to avoid detection by using a variety of untested adulterant products (e.g., shampoos, cleansers) widely sold online. This study aims to investigate adulteration of hair samples and to assess effectiveness of such methods. METHODS: The literature on hair test evasion was searched for on PubMed or MEDLINE, Psycinfo, and Google Scholar...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28558421/phthalate-metabolites-in-norwegian-mothers-and-children-levels-diurnal-variation-and-use-of-personal-care-products
#11
Amrit Kaur Sakhi, Azemira Sabaredzovic, Enrique Cequier, Cathrine Thomsen
Exposure to phthalates has been associated with reproductive and developmental toxicity. Data on levels of these compounds in the Norwegian population is limited. In this study, urine samples were collected from 48 mothers and their children in two counties in Norway. Eleven different phthalate metabolites originating from six commonly used phthalates in consumer products were determined. Concentrations of phthalate metabolites were significantly higher in children compared to mothers except for mono-ethyl phthalate (MEP)...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28547667/metalloproteomics-approach-to-analyze-mercury-in-breast-milk-and-hair-samples-of-lactating-women-in-communities-of-the-amazon-basin-brazil
#12
M R Cerbino, José Cavalcante Souza Vieira, C P Braga, G Oliveira, I F Padilha, T M Silva, L F Zara, N J Silva, P M Padilha
Mercury is a potentially toxic element that is present in the environment of the Brazilian Amazon and is responsible for adverse health effects in humans. This study sought to assess possible protein biomarkers of mercury exposure in breast milk samples from lactating women in the Madeira and Negro Rivers in the Brazilian Amazon. The mercury content of hair samples of lactating women was determined, and the proteome of breast milk samples was obtained using two-dimensional electrophoresis after protein precipitation with acetone...
May 25, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28545513/cross-sectional-assessment-of-infants-exposure-to-toxic-metals-through-breast-milk-in-a-prospective-cohort-study-of-mining-communities-in-ghana
#13
David Kwaku Bansa, Adolf Kofi Awua, Rose Boatin, Theodosia Adom, Edward Christian Brown-Appiah, Kennedy Kwame Amewosina, Akusika Diaba, Dominic Datoghe, Wilhelmina Okwabi
BACKGROUND: Although breastfeeding of infants is recommended globally, the fact that maternal toxic metal stores are mobilised into breast milk implies infants, whose mothers live and work in mining communities, are at risk of multiple exposure to mining related toxic metals, such as Lead (Pb), Mercury (Hg), Cadmium (Cd) and Arsenic (As), through breast milk intake, in addition to in utero exposure. METHOD: A total of 114 mother-baby pairs, recruited from two community hospitals servicing mining communities in two different regions in Ghana (57 each), were involved in this study...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28533160/cancer-treatment-side-effects-a-meta-analysis-of-the-relationship-between-response-expectancies-and-experience
#14
REVIEW
Elise J Devlin, Linley A Denson, Hayley S Whitford
CONTEXT: Although previous research has, overall, suggested a moderate relationship between response expectancies (REs) and cancer treatment-related side-effects, empirical results have been mixed. OBJECTIVES: We aimed to further explore these relationships, hypothesizing that REs would predict subsequent toxicities with the inclusion of more recent studies, across a broader range of side-effects, while incorporating the impact of potential moderators including patients' experience with treatment and measurement methods...
May 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28503992/dose-dependent-effects-of-ouabain-on-spiral-ganglion-neurons-and-schwann-cells-in-mouse-cochlea
#15
Zhi-Jian Zhang, Hong-Xia Guan, Kun Yang, Bo-Kui Xiao, Hua Liao, Yang Jiang, Tao Zhou, Qing-Quan Hua
OBJECTIVE: This study aimed in fully investigating the toxicities of ouabain to mouse cochlea and the related cellular environment, and providing an optimal animal model system for cell transplantation in the treatment of auditory neuropathy (AN) and sensorineural hearing loss (SNHL). METHODS: Different dosages of ouabain were applied to mouse round window. The auditory brainstem responses and distortion product otoacoustic emissions were used to evaluate the cochlear function...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28503132/protecting-mammalian-hair-cells-from-aminoglycoside-toxicity-assessing-phenoxybenzamine-s-potential
#16
Paromita Majumder, Paulette A Moore, Guy P Richardson, Jonathan E Gale
Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic, causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering agents that protect against aminoglycoside ototoxicity have focused on inhibiting apoptosis or more recently, on preventing antibiotic uptake by the hair cells. Recent screens for ototoprotective compounds using the larval zebrafish lateral line identified phenoxybenzamine as a potential protectant for aminoglycoside-induced hair cell death...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28481096/cuo-and-zno-nanoparticles-modify-interkingdom-cell-signaling-processes-relevant-to-crop-production-a-review
#17
Anne Anderson, Joan E McLean, Astrid Rosa Jacobson, David Britt
As the world population increases, strategies for sustainable agriculture are needed to fulfill the global need for plants for food and other commercial products. Nanoparticle formulations are likely to be part of the developing strategies. CuO and ZnO nanoparticles (NPs) offer potential as fertilizers, as they provide bioavailable essential metals, and as pesticides, because of dose-dependent toxicity. Effects of these metal oxide NPs on rhizosphere functions are the focus of this review. These NPs at doses of 10 mg metal/kg and above change production of key metabolites involved in plant protection in a root-associated microbe, Pseudomonas chlororaphis O6...
May 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28470226/flexible-and-highly-interconnected-multi-scale-patterned-chitosan-porous-membrane-produced-in-situ-from-mussel-shell-to-accelerate-wound-healing
#18
Xiaoping Song, Jie Mei, Xingying Zhang, Leyu Wang, Gurankit Singh, Malcolm M Q Xing, Xiaozhong Qiu
Utilization of the underlying mechanisms of biological systems is the principal endeavor of biomimetics, the primary goal of which is to treat on-going biological processes. From the perspective of tissue engineering, one purpose of biomimetics is to create highly cellular- or tissue-favored environments for bio-defect repair. Marine creatures such as mussels have inspired bioengineers to design ideal cellular substrates, strong adhesives, and other bioengineering materials. Herein, we report a novel mussel shell-derived membrane for wound dressing...
May 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28463045/mitigation-of-epidermal-growth-factor-receptor-inhibitor-induced-side-effects-utilizing-melanin-and-vascular-specific-lasers-a-case-report-series
#19
Karen Y Kuo, Bernice Kwong, Zakia Rahman
The advent of targeted chemotherapy has led to the emergence of new dermatologic toxicities. We sought to use lasers and light devices to treat recalcitrant cutaneous adverse effects related to cancer treatment. Three stage III or IV cancer patients with cutaneous complications due to epidermal growth factor receptor (EGFR) inhibitors were treated with melanin and vascular-specific laser and light technologies. Two patients reported reduction in papulopustular eruption following pulse dye laser (PDL) treatment...
March 2, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28447188/chemometric-evaluation-of-elemental-imbalances-in-the-scalp-hair-of-valvular-heart-disease-patients-in-comparison-with-healthy-donors
#20
Asim Ilyas, Munir H Shah
The present study deals with the plausible association between the trace elemental imbalances and the emergence of valvular heart disease (VHD). A total of 14 elements including Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Pb, Sr and Zn in the scalp hair of VHD patients and healthy donors were analysed by flame atomic absorption spectrophometry employing wet acid digestion methodology. Median levels of Cu, Fe, Mg, Mn and Sr in the scalp hair of patients were significantly higher compared to those of the healthy donors, while the median concentrations of K and Na were found to be considerably higher in the scalp hair of the healthy donors...
April 26, 2017: Biological Trace Element Research
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