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https://www.readbyqxmd.com/read/29785585/poisoning-associated-with-inappropriate-use-of-a-eutectic-mixture-of-lidocaine-and-prilocaine-before-laser-assisted-hair-removal-about-3-cases
#1
Weniko Caré, Islam-Amine Larabi, Jérôme Langrand, Chantal Medernach, Jean-Claude Alvarez, Antoine Villa
BACKGROUND: Eutectic mixtures of lidocaine and prilocaine are used during painful dermatological procedures. Poisoning is rarely reported in adults. MATERIAL AND METHOD: We report three cases of women who experienced lidocaine and prilocaine poisoning after laser-assisted hair removal. Plasma levels of local anesthetics were assayed by a fully validated liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method. CASE REPORTS: The rules of application of the anesthetic cream were observed apart from the maximum dose and/or maximum surface area...
May 21, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29785318/role-of-nanotechnology-in-cosmeceuticals-a-review-of-recent-advances
#2
REVIEW
Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, Upendra Nagaich
Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use...
2018: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29747313/-clinical-observation-of-apatinib-mesylate-for-the-treatment-of-multi-drug-resistant-advanced-breast-cancer
#3
H M Lü, M W Zhang, L M Niu, H A Zeng, M Yan
Objective: To assess the clinical efficacy and adverse outcomes of apatinib mesylate for the treatment of multi-drug resistant advanced breast cancer. Methods: A total of 24 patients with multi-drug-resistant advanced breast cancer who underwent apatinib mesylate treatment were retrospectively analyzed at the Diagnosis and Treatment Center for Breast Cancer of Henan Cancer Hospital. Patients were reviewed every 4 weeks after initial treatment and then every 8 weeks after stable disease. Objective response rate (ORR), progression free survival (PFS), overall survival (OS) , toxicity and adverse outcomes of apatinib mesylate treatment were evaluated by imaging examinations...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29734052/critical-analysis-of-forensic-cut-offs-and-legal-thresholds-a-coherent-approach-to-inference-and-decision
#4
A Biedermann, F Taroni, S Bozza, M Augsburger, C G G Aitken
In this paper we critically discuss the definition and use of cut-off values by forensic scientists, for example in forensic toxicology, and point out when and why such values - and ensuing categorical conclusions - are inappropriate concepts for helping recipients of expert information with their questions of interest. Broadly speaking, a cut-off is a particular value of results of analyses of a target substance (e.g., a toxic substance or one of its metabolites in biological sample from a person of interest), defined in a way such as to enable scientists to suggest conclusions regarding the condition of the person of interest...
April 25, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29722443/biomonitoring-of-bisphenol-a-triclosan-and-perfluorooctanoic-acid-in-hair-samples-of-children-and-adults
#5
Vasiliki Karzi, Manolis N Tzatzarakis, Elena Vakonaki, Thanasis Alegakis, Ioanna Katsikantami, Stavros Sifakis, Apostolos Rizos, Aristidis M Tsatsakis
Bisphenol A (BPA), triclosan (TCS) and perfluorooctanoic acid (PFOA) are endocrine disruptors linked with negative health effects such as developmental, reproductive and cardiovascular toxicity. The aim of this study was to determine simultaneously the concentration of BPA, TCS and PFOA in hair from children and adults and examine possible associations between biomonitoring data and age, gender, dietary habits and body mass index. Methanolic extraction was applied and the compounds were determined by liquid chromatography-mass spectrometry...
May 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29719206/neuromast-hair-cells-retain-the-capacity-of-regeneration-during-heavy-metal-exposure
#6
G Montalbano, G Capillo, R Laurà, F Abbate, M Levanti, M C Guerrera, E Ciriaco, A Germanà
The neuromast is the morphological unit of the lateral line of fishes and is composed of a cluster of central sensory cells (hair cells) surrounded by support and mantle cells. Heavy metals exposure leads to disruption of hair cells within the neuromast. It is well known that the zebrafish has the ability to regenerate the hair cells after damage caused by toxicants. The process of regeneration depends on proliferation, differentiation and cellular migration of sensory and non-sensory progenitor cells. Therefore, our study was made in order to identify which cellular types are involved in the complex process of regeneration during heavy metals exposure...
April 29, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29709849/sources-behaviour-and-environmental-and-human-health-risks-of-high-technology-rare-earth-elements-as-emerging-contaminants
#7
REVIEW
Willis Gwenzi, Lynda Mangori, Concilia Danha, Nhamo Chaukura, Nothando Dunjana, Edmond Sanganyado
Recent studies show that high-technology rare earth elements (REEs) of anthropogenic origin occur in the environment including in aquatic systems, suggesting REEs are contaminants of emerging concern. However, compared to organic contaminants, there is a lack of comprehensive reviews on the anthropogenic sources, environmental behaviour, and public and ecological health risks of REEs. The current review aims to: (1) identify anthropogenic sources, transfer mechanisms, and environmental behaviour of REEs; (2) highlight the human and ecological health risks of REEs and propose mitigation measures; and (3) identify knowledge gaps and future research directions...
April 26, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29700610/methylboronic-acid-fertilization-alleviates-boron-deficiency-symptoms-in-arabidopsis-thaliana
#8
Catherine Duran, Patricio Arce-Johnson, Felipe Aquea
Our results showed that methylboronic acid is capable of alleviating boron deficiency, enhancing plant growth, and is less toxic than boric acid at higher concentrations. Boron is an essential plant micronutrient and its deficiency occurs in several regions globally, resulting in impaired plant growth. Boron fertilization is a common agricultural practice, but the action range of boron is narrow, sharply transitioning from deficiency to toxicity. Boric acid (BA) is the most common chemical form used in agriculture...
April 26, 2018: Planta
https://www.readbyqxmd.com/read/29699754/topically-applied-curcumin-loaded-nanoparticles-treat-erectile-dysfunction-in-a-rat-model-of-type-2-diabetes
#9
Andrew Draganski, Moses T Tar, Guillermo Villegas, Joel M Friedman, Kelvin P Davies
BACKGROUND: Curcumin, a naturally occurring anti-inflammatory compound, has shown promise in pre-clinical studies to treat erectile dysfunction (ED) associated with type-1 diabetes. However, poor bioavailability following oral administration limits its efficacy. The present study evaluated the potential of topical application of curcumin-loaded nanoparticles (curc-np) to treat ED in a rat model of type-2 diabetes (T2D). AIM: Determine if topical application of curc-np treats ED in a T2D rat model and modulates expression of inflammatory markers...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29665641/evaluation-of-the-toxicity-of-colocasia-esculenta-aracaceae-preliminary-study-of-leaves-infected-by-phytophthora-colocasiae-on-wistar-albinos-rats
#10
Doriane Camille Nyonseu Nzebang, Marie Ide Ngaha Njila, Emma Fortune Bend, Pierre Claver Oundoum Oundoum, Brice Landry Koloko, Calvin Bogning Zangueu, Philippe Belle Ekedi, Modeste Sameza, Dieudonné Massoma Lembè
This study was designed to investigate the acute and subacute toxicity of the aqueous extract from colocasia esculenta (CE) leaves infected by Phytophthora colocsiae (PC) in rats. Toxicity of the aqueous extract was evaluated in both male and female wistar rats after a single administration (Acute model) and during 21 days (subacute model). Acute administration of the extract up to a dose 4000 mg/kg did not induce treatment related signs of toxicity or mortality of any rat tested. Therefore, LD50 was estimated to be more than 4000 mg/kg...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29643913/hair-dye-poisoning-an-early-intervention
#11
Syed Farrukh Umair, Imrana Amin, Ata Urrehman
The use of hair dye has been emerging worldwide however usage of Paraphenylenediamine (PPD) in making hair dye is generally restricted to underdeveloped and developing countries. In particular, prevalence of accidental and suicidal ingestion is more in low socioeconomic areas. The spectra of hair dye toxicity is wide, however, it presents more commonly with severe angioedema of face and neck leading to respiratory failure, rhabdomyolysis complicating into acute kidney injury, myocarditis and acute liver injury...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29621677/svalbard-reindeer-as-an-indicator-of-ecosystem-changes-in-the-arctic-terrestrial-ecosystem
#12
Aneta Dorota Pacyna, Katarzyna Koziorowska, Stanisław Chmiel, Jan Mazerski, Żaneta Polkowska
Over the years, noticeable effort has been directed towards contaminant determination in multiple biotic samples collected from the inhabitants of the Arctic. Little consideration has been given to polar herbivores, however, especially those from the European parts of the Arctic. To provide a broader perspective, we aimed to decipher trace element concentration in hairs of the key species in the Arctic, namely the Svalbard reindeer (Rangifer tarandus platyrhynchus), and to recognise whether diet variations could correspond with forward exposure...
March 23, 2018: Chemosphere
https://www.readbyqxmd.com/read/29619567/ecotoxicological-evaluation-of-two-anti-dandruff-hair-shampoos-using-lemna-minor
#13
Azizullah Azizullah, Shakirullah Khan Shakir, Shahana Shoaib, Halima Bangash, Nadia Taimur, Waheed Murad, Muhammad Khan Daud
Hair shampoos, a mixture of various organic and organic compounds, are commonly used personnel care products. Since shampoos are used in almost every household and beauty shop, their ingredients are common components of domestic and municipal wastewater. However, studies on the effect of shampoos to aquatic plants can hardly be found in literature. Therefore, the present study was conducted to investigate the phytotoxic effects of two commonly used anti-dandruff shampoos (named here AD 1 and AD 2) using Lemna minor as a biotest organism...
April 4, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29615003/role-of-cytarabine-in-paediatric-acute-promyelocytic-leukemia-treated-with-the-combination-of-all-trans-retinoic-acid-and-arsenic-trioxide-a-randomized-controlled-trial
#14
Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu
BACKGROUND: The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C) in APL was controversial. The aim of this study was to test the efficacy and safety of ATRA and ATO in paediatric APL patients. Also, we assessed whether Ara-C could be omitted in ATO and ATRA- based trials in children. METHODS: We performed a randomized controlled trial in paediatric APL patients (≤14 years of age) in our hospital from May 2010 to December 2016...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29609715/segmental-hair-testing-of-triazolam-to-unmask-a-suspected-case-of-idiopathic-recurrent-stupor
#15
Emanuela Postiglione, Elena Antelmi, Monica Moresco, Simona Pichini, Fabio Pizza, Giuseppe Plazzi, Francesco Paolo Busardò
Stupor is a diagnostic challenge at emergency department. Differential diagnosis includes idiopathic recurrent stupor, formerly attributed to "endozepine-4" accumulation. This condition has been recently questioned because many suspected cases resulted in exogenous benzodiazepine intake that eludes the conventional toxicological assay. In case of unexplained recurrent stupor, to extend the benzodiazepine search in nonconventional matrices can allow unmasking of hidden toxic behavior.
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29609517/pd-1-inhibition-minimally-affects-cisplatin-induced-toxicities-in-a-murine-model
#16
Katie Spielbauer, Lisa Cunningham, Nicole Schmitt
Immune checkpoint inhibition used in combination with standard cisplatin-based chemotherapy regimens is currently under evaluation in clinical trials for head and neck squamous cell carcinoma (HNSCC). The impact of anti-PD-1 therapy on cisplatin-induced ototoxicity and nephrotoxicity has not been established. Here we use a murine model of cisplatin-induced hearing loss to investigate the impact of anti-PD-1 immunotherapy on auditory brainstem responses (ABRs), distortion product otoacoustic emissions (DPOAEs), serum creatinine, and hair cell and renal histology...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29607753/histopathology-of-cutaneous-inflammatory-disorders-in-children
#17
Andy C Hsi, Ilana S Rosman
Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Exceptions include erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis, where the etiology is often due to infection or ingested medications, but the histologic features are almost exclusively confined to the epidermis and dermoepidermal junction...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29590104/autophagy-is-essential-for-maintaining-the-growth-of-a-human-mini-organ-evidence-from-scalp-hair-follicle-organ-culture
#18
Chiara Parodi, Jonathan A Hardman, Giulia Allavena, Roberto Marotta, Tiziano Catelani, Marta Bertolini, Ralf Paus, Benedetto Grimaldi
Autophagy plays a crucial role in health and disease, regulating central cellular processes such as adaptive stress responses, differentiation, tissue development, and homeostasis. However, the role of autophagy in human physiology is poorly understood, highlighting a need for a model human organ system to assess the efficacy and safety of strategies to therapeutically modulate autophagy. As a complete, cyclically remodelled (mini-)organ, the organ culture of human scalp hair follicles (HFs), which, after massive growth (anagen), spontaneously enter into an apoptosis-driven organ involution (catagen) process, may provide such a model...
March 2018: PLoS Biology
https://www.readbyqxmd.com/read/29577855/nanoparticles-in-cancer-treatment-opportunities-and-obstacles
#19
Rajendra Awasthi, Ariane Roseblade, Philip Michael Hansbro, Michael John Rathbone, Kamal Dua, Mary Bebawy
In the United States, the estimated number of new cancer cases in 2018 was approx. 1.7 million. Historically, combination chemotherapy has been the primary choice of treatment. However, chemotherapeutics have pharmaceutical limitations, among which include problems with stability and aqueous solubility. Likewise, dose limiting toxicity is significant with nonspecific toxicity to healthy cells, hair loss, loss of appetite, peripheral neuropathy and diarrhea being typical side effects. The emergence of Multidrug resistance (MDR) also presents s a significant challenge for the successful treatment of cancer whereby cancer cells become cross resistant to many of the chemotherapeutic agents used...
March 26, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29576427/dermatologic-toxicity-occurring-during-anti-egfr-monoclonal-inhibitor-therapy-in-patients-with-metastatic-colorectal-cancer-a-systematic-review
#20
REVIEW
Mario E Lacouture, Milan Anadkat, Aminah Jatoi, Tamer Garawin, Chet Bohac, Edith Mitchell
Monoclonal antibody inhibitors of the epidermal growth factor receptor (EGFR) have been shown to improve outcomes for patients with metastatic colorectal cancer (mCRC) without RAS gene mutations. However, treatment with anti-EGFR agents can be associated with toxicities of the skin, nails, hair, and eyes. Because these dermatologic toxicities can result in treatment discontinuation and affect patient quality of life, their management is an important focus when administering anti-EGFR monoclonal antibodies. The present systematic review describes the current data reporting the nature and incidence of, and management and treatment options for, dermatologic toxicities occurring during anti-EGFR treatment of mCRC...
December 13, 2017: Clinical Colorectal Cancer
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