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Nicholas Ahn

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https://www.readbyqxmd.com/read/27893897/imaging-of-glial-cell-activation-and-white-matter-integrity-in-brains-of-active-and-recently-retired-national-football-league-players
#1
Jennifer M Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B Ambinder, Xin Xu, Matthew E Peters, John W Dougherty, Melin Vranesic, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, Chris Cottrell, Haris I Sair, Akira Sawa, Cynthia A Munro, Christopher J Nowinski, Robert F Dannals, Constantine G Lyketsos, Michael Kassiou, Gwenn Smith, Brian Caffo, Susumu Mori, Tomas R Guilarte, Martin G Pomper
Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27831969/decompression-vs-decompression-and-fusion-for-degenerative-lumbar-stenosis-dls-in-a-workers-compensation-setting
#2
Erik Y Tye, Joshua Anderson, Arnold Haas, Rick Percy, Stephen T Woods, Nicholas Ahn
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare outcomes in Workers' compensation (WC) subjects receiving decompression alone versus decompression and fusion for the indication of degenerative spinal stenosis (DLS) without deformity or instability. SUMMARY OF BACKGROUND DATA: The use of a fusion procedure during lumbar decompression for DLS alone remains controversial. We hypothesize that WC subjects receiving fusion and decompression will return to work less and incur greater medical costs compared to subjects receiving decompression alone...
November 9, 2016: Spine
https://www.readbyqxmd.com/read/27797182/stable-metal-organic-framework-supported-niobium-catalysts
#3
Sol Ahn, Nicholas E Thornburg, Zhanyong Li, Timothy C Wang, Leighanne C Gallington, Karena W Chapman, Justin M Notestein, Joseph T Hupp, Omar K Farha
Developing structurally well-defined, supported oxide catalysts remains a significant challenge. Here, we report the grafting of Nb(V) oxide sites onto the nodes of the Zr-based metal organic framework (MOF) NU-1000 as a stable, well-defined catalyst support. Nb(V) oxide was deposited with loadings up to 1.6 mmol/g via two postsynthetic methods: atomic layer deposition in a MOF, and solution-phase grafting in a MOF. Difference envelope density measurements indicated that the two synthetic methods resulted in different local structures of the Nb(V) ions within NU-1000...
October 31, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27755643/neck-pain-preoperative-opioids-and-functionality-after-cervical-fusion
#4
Mhamad Faour, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
The use of opioids among patients with workers' compensation claims is associated with tremendous costs, especially for patients who undergo spinal surgery. This study compared return-to-work rates after single-level cervical fusion for degenerative disk disease between patients who received opioids before surgery and patients who underwent fusion with no previous opioid use. All study subjects qualified for workers' compensation benefits for injuries sustained at work between 1993 and 2011. The study population included 281 subjects who underwent single-level cervical fusion for degenerative disk disease with International Classification of Diseases, Ninth Revision, and Current Procedural Terminology code algorithms...
October 18, 2016: Orthopedics
https://www.readbyqxmd.com/read/27684084/spondylolysis-and-end-plate-arthrosis-at-l5-s1-a-cadaveric-study
#5
Peter T McCunniff, Hojun Yoo, Charles Yu, Navkirat S Bajwa, Jason O Toy, Uri M Ahn, Nicholas Ahn
This study examined the effect of bilateral and unilateral L5 pars defects on the degree of disk degeneration at the L5-S1 level in cadaveric specimens. An observational study was performed of 690 cadaveric specimens selected at random. These specimens represent individuals who died between 1893 and 1938. The study included 558 male and 132 female cadavers. Of the 120 specimens with L5 spondylolysis, 95 cases were bilateral and 25 were unilateral. The remaining 544 specimens were used as the control cohort...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27575040/calcaneocuboid-joint-arthritis-of-the-midfoot-precedes-tibiotalar-joint-arthritis
#6
Anthony Dugarte, Sahil Bharwani, HoJun Yoo, Alexander Vondra Boiwka, Charles C Yu, Navkirat S Bajwa, Jason O Toy, Jonathan E Tang, Uri Ahn, Nicholas Ahn
Surgical models have best shown the relationship between ankle and mid-foot osteoarthritis, although findings regarding the calcaneocuboid joint have varied. To the authors' knowledge, no studies have evaluated the relationship between degenerative changes across the tibiotalar and calcaneocuboid joints. The goal of this study was to determine whether such a relationship exists and which joint degenerates first. A single examiner evaluated 694 tibiotalar and calcaneocuboid joints to determine the presence of osteoarthritis...
November 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27398795/return-to-work-rates-after-single-level-cervical-fusion-for-degenerative-disc-disease-compared-with-fusion-for-radiculopathy-in-a-workers-compensation-setting
#7
Mhamad Faour, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: A retrospective comparative cohort study. OBJECTIVE: To compare return to work (RTW) rates for patients who underwent single-level cervical fusion for radiculopathy compared with fusion for degenerative disc disease (DDD) as an indication for surgery. SUMMARY OF BACKGROUND DATA: Studies have shown that workers' compensation subjects have less favorable surgical and functional outcomes compared with the general population. Cervical decompression and fusion have provided great results with relieving radicular symptoms...
July 15, 2016: Spine
https://www.readbyqxmd.com/read/27391855/discovery-of-a-selective-covalent-inhibitor-of-lysophospholipase-like-1-lyplal1-as-a-tool-to-evaluate-the-role-of-this-serine-hydrolase-in-metabolism
#8
Kay Ahn, Markus Boehm, Matthew F Brown, Jessica Calloway, Ye Che, Jinshan Chen, Kimberly F Fennell, Kieran F Geoghegan, Adam M Gilbert, Jemy A Gutierrez, Amit S Kalgutkar, Adhiraj Lanba, Chris Limberakis, Thomas V Magee, Inish O'Doherty, Robert Oliver, Brandon Pabst, Jayvardhan Pandit, Kevin Parris, Jeffrey A Pfefferkorn, Timothy P Rolph, Rushi Patel, Brandon Schuff, Veerabahu Shanmugasundaram, Jeremy T Starr, Alison H Varghese, Nicholas B Vera, Cecile Vernochet, Jiangli Yan
Lysophospholipase-like 1 (LYPLAL1) is an uncharacterized metabolic serine hydrolase. Human genome-wide association studies link variants of the gene encoding this enzyme to fat distribution, waist-to-hip ratio, and nonalcoholic fatty liver disease. We describe the discovery of potent and selective covalent small-molecule inhibitors of LYPLAL1 and their use to investigate its role in hepatic metabolism. In hepatocytes, selective inhibition of LYPLAL1 increased glucose production supporting the inference that LYPLAL1 is a significant actor in hepatic metabolism...
September 16, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27286049/ipsilateral-tibiotalar-joint-osteoarthritis-transferred-to-the-contralateral-tibiotalar-joint
#9
Anthony Dugarte, Sahil Bharwani, HoJun Yoo, Alexander Vondra Boiwka, Jonathan E Tang, Uri M Ahn, Nicholas U Ahn
Classically, it is thought that pain or disability in one leg can stress the contralateral leg, leading to similar symptoms. The mechanism of action for subsequent dysfunction in the healthy limb is thought to involve compensatory changes that are used as a means to reduce stance phase time on the injured limb. This is believed to increase the forces distributed across the healthy limb, ultimately leading to injury. This belief has been challenged, as supportive literature is sparse. The goal of this study was to determine whether an association between tibiotalar (TT) osteoarthritis (OA) in the right vs left lower extremity exists, and whether injury to one lower extremity leads to degeneration in the contralateral lower extremity...
July 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27224882/prolonged-preoperative-opioid-therapy-associated-with-poor-return-to-work-rates-after-single-level-cervical-fusion-for-radiculopathy-for-patients-receiving-workers-compensation-benefits
#10
Mhamad Faour, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective comparative cohort study. OBJECTIVE: Examine the impact of prolonged preoperative opioid use on return to work status after single-level cervical fusion for radiculopathy. SUMMARY OF BACKGROUND DATA: The use of opioids has a dramatic impact in a workers' compensation population. The costs of claims that involved opioids in the management plan are catastrophic particularly for those undergoing spinal surgical procedure...
July 8, 2016: Spine
https://www.readbyqxmd.com/read/27224880/return-to-work-and-multi-level-versus-single-level-cervical-fusion-for-radiculopathy-in-a-workers-compensation-setting
#11
Mhamad Faour, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective comparative cohort study. OBJECTIVE: Examine the impact of multi-level fusion on return to work (RTW) status and compare RTW status after multi- vs. single-level cervical fusion for patients with work-related injury. SUMMARY OF BACKGROUND DATA: Patients with work-related injuries in the workers' compensation systems have less favorable surgical outcomes. Cervical fusion provides a greater than 90% likelihood of relieving radiculopathy and stabilizing or improving myelopathy...
May 24, 2016: Spine
https://www.readbyqxmd.com/read/27111080/chronic-antiplatelet-use-associated-with-increased-blood-loss-in-lumbar-spinal-surgery-despite-adherence-to-protocols
#12
Peter T McCunniff, Ernest S Young, Kasra Ahmadinia, David J Kusin, Uri M Ahn, Nicholas U Ahn
There are conflicting reports regarding postoperative bleeding risks associated with discontinuation of antiplatelet therapy at least 7 days preoperatively. Most of the studies in the spine literature are based on surveys or anecdotal evidence. The majority of surgeons discontinue therapy 7 days preoperatively, but this varies widely from 5 to 21 days. The purpose of this retrospective study was to assess whether chronic antiplatelet use is associated with increased intraoperative blood loss, need for transfusion, and perioperative complications...
July 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27043195/does-tobacco-use-attenuate-benefits-of-early-decompression-in-patients-with-cervical-myelopathy
#13
David J Kusin, Samuel Q Li, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective Cohort OBJECTIVE.: This study investigates the interplay between duration of preoperative symptoms and smoking status with respect to postoperative outcomes in patients with cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: Many studies have established the harms of smoking and several have identified the benefits of early decompression in patients with cervical myelopathy, but to our knowledge none have assessed the relationship between these two variables...
March 31, 2016: Spine
https://www.readbyqxmd.com/read/26974831/the-influence-of-diabetes-on-surgical-outcomes-in-cervical-myelopathy
#14
David J Kusin, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: A retrospective cohort. OBJECTIVE: The objective of the study was to determine what effect, if any, diabetes has on surgical outcomes in patients with cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: Diabetes is known to impair healing and has been shown to affect outcomes in lumbar surgery, but few studies have assessed outcomes in cervical surgery, and cervical myelopathy in particular. METHODS: The records of 113 patients operated on by one surgeon were reviewed...
September 15, 2016: Spine
https://www.readbyqxmd.com/read/26709561/workers-compensation-return-to-work-and-lumbar-fusion-for-spondylolisthesis
#15
Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
Lumbar fusion for spondylolisthesis is associated with consistent outcomes in the general population. However, workers' compensation is a risk factor for worse outcomes. Few studies have evaluated prognostic factors within this clinically distinct population. The goal of this study was to identify prognostic factors for return to work among patients with workers' compensation claims after fusion for spondylolisthesis. The authors used International Classification of Diseases, Ninth Revision, and Current Procedural Terminology codes to identify 686 subjects from the Ohio Bureau of Workers' Compensation who underwent fusion for spondylolisthesis from 1993 to 2013...
January 2016: Orthopedics
https://www.readbyqxmd.com/read/26691988/a-large-genome-wide-association-study-of-age-related-macular-degeneration-highlights-contributions-of-rare-and-common-variants
#16
Lars G Fritsche, Wilmar Igl, Jessica N Cooke Bailey, Felix Grassmann, Sebanti Sengupta, Jennifer L Bragg-Gresham, Kathryn P Burdon, Scott J Hebbring, Cindy Wen, Mathias Gorski, Ivana K Kim, David Cho, Donald Zack, Eric Souied, Hendrik P N Scholl, Elisa Bala, Kristine E Lee, David J Hunter, Rebecca J Sardell, Paul Mitchell, Joanna E Merriam, Valentina Cipriani, Joshua D Hoffman, Tina Schick, Yara T E Lechanteur, Robyn H Guymer, Matthew P Johnson, Yingda Jiang, Chloe M Stanton, Gabriëlle H S Buitendijk, Xiaowei Zhan, Alan M Kwong, Alexis Boleda, Matthew Brooks, Linn Gieser, Rinki Ratnapriya, Kari E Branham, Johanna R Foerster, John R Heckenlively, Mohammad I Othman, Brendan J Vote, Helena Hai Liang, Emmanuelle Souzeau, Ian L McAllister, Timothy Isaacs, Janette Hall, Stewart Lake, David A Mackey, Ian J Constable, Jamie E Craig, Terrie E Kitchner, Zhenglin Yang, Zhiguang Su, Hongrong Luo, Daniel Chen, Hong Ouyang, Ken Flagg, Danni Lin, Guanping Mao, Henry Ferreyra, Klaus Stark, Claudia N von Strachwitz, Armin Wolf, Caroline Brandl, Guenther Rudolph, Matthias Olden, Margaux A Morrison, Denise J Morgan, Matthew Schu, Jeeyun Ahn, Giuliana Silvestri, Evangelia E Tsironi, Kyu Hyung Park, Lindsay A Farrer, Anton Orlin, Alexander Brucker, Mingyao Li, Christine A Curcio, Saddek Mohand-Saïd, José-Alain Sahel, Isabelle Audo, Mustapha Benchaboune, Angela J Cree, Christina A Rennie, Srinivas V Goverdhan, Michelle Grunin, Shira Hagbi-Levi, Peter Campochiaro, Nicholas Katsanis, Frank G Holz, Frédéric Blond, Hélène Blanché, Jean-François Deleuze, Robert P Igo, Barbara Truitt, Neal S Peachey, Stacy M Meuer, Chelsea E Myers, Emily L Moore, Ronald Klein, Michael A Hauser, Eric A Postel, Monique D Courtenay, Stephen G Schwartz, Jaclyn L Kovach, William K Scott, Gerald Liew, Ava G Tan, Bamini Gopinath, John C Merriam, R Theodore Smith, Jane C Khan, Humma Shahid, Anthony T Moore, J Allie McGrath, Reneé Laux, Milam A Brantley, Anita Agarwal, Lebriz Ersoy, Albert Caramoy, Thomas Langmann, Nicole T M Saksens, Eiko K de Jong, Carel B Hoyng, Melinda S Cain, Andrea J Richardson, Tammy M Martin, John Blangero, Daniel E Weeks, Bal Dhillon, Cornelia M van Duijn, Kimberly F Doheny, Jane Romm, Caroline C W Klaver, Caroline Hayward, Michael B Gorin, Michael L Klein, Paul N Baird, Anneke I den Hollander, Sascha Fauser, John R W Yates, Rando Allikmets, Jie Jin Wang, Debra A Schaumberg, Barbara E K Klein, Stephanie A Hagstrom, Itay Chowers, Andrew J Lotery, Thierry Léveillard, Kang Zhang, Murray H Brilliant, Alex W Hewitt, Anand Swaroop, Emily Y Chew, Margaret A Pericak-Vance, Margaret DeAngelis, Dwight Stambolian, Jonathan L Haines, Sudha K Iyengar, Bernhard H F Weber, Gonçalo R Abecasis, Iris M Heid
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4...
February 2016: Nature Genetics
https://www.readbyqxmd.com/read/26652326/return-to-work-after-diskogenic-fusion-in-workers-compensation-subjects
#17
Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
Lumbar fusion for degenerative disk disease (DDD) is associated with variable clinical outcomes. Patients with workers' compensation claims often have worse fusion outcomes than the general population. Few studies have evaluated the risk factors for poor outcomes within this clinically distinct population. The goal of this study was to identify preoperative predictors of return to work status after fusion for DDD in a workers' compensation setting. The authors used International Classification of Diseases, Ninth Revision (ICD-9), diagnosis and Current Procedural Terminology (CPT) procedural codes to identify 1037 subjects from the Ohio Bureau of Workers' Compensation database who underwent fusion for DDD between 1993 and 2013...
December 2015: Orthopedics
https://www.readbyqxmd.com/read/26642788/smoking-is-associated-with-increased-blood-loss-and-transfusion-use-after-lumbar-spinal-surgery
#18
Peter T McCunniff, Ernest S Young, Kasra Ahmadinia, Uri M Ahn, Nicholas U Ahn
BACKGROUND: Little is known about the association between smoking and intraoperative blood loss and perioperative transfusion use in patients undergoing spinal surgery. However, we found that although many of the common complications and deleterious effects of smoking on surgical patients had been well documented, the aspect of blood loss seemingly had been overlooked despite data reported in nonorthopaedic sources to suggest a possible connection. QUESTIONS/PURPOSES: We asked: (1) Is smoking associated with increased estimated blood loss during surgery in patients undergoing lumbar spine surgery? (2) Is smoking associated with increased perioperative transfusion usage? METHODS: Between 2005 and 2009, 581 lumbar decompression procedures (with or without fusion) were performed at one academic spine center...
April 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26558673/lumbar-diskography-and-failed-back-syndrome-in-patients-receiving-workers-compensation
#19
Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
Lumbar diskography (LD) is frequently used in the evaluation of patients with degenerative disk disease and diskogenic low back pain. Its safety and diagnostic accuracy are a topic of debate. No study has evaluated the efficacy of LD within the clinically distinct workers' compensation population. Within this setting, the authors wished to determine the effect of undergoing LD before diskogenic fusion on rates of postoperative failed back surgery syndrome (FBSS). Also, the authors compared opioid analgesic use between patients undergoing LD and patients not undergoing LD...
November 2015: Orthopedics
https://www.readbyqxmd.com/read/26426709/the-effect-of-smoking-on-spinal-cord-healing-following-surgical-treatment-of-cervical-myelopathy
#20
David J Kusin, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective cohort. OBJECTIVE: The purpose of this study was to compare outcomes of surgical treatment of cervical myelopathy between smokers and nonsmokers as assessed by the Nurick score. SUMMARY OF BACKGROUND DATA: The harmful effects of smoking on healing have been well established. However, the effect of smoking on postoperative outcomes for cervical myelopathy has not been specifically evaluated. METHODS: The medical records of 212 patients who underwent surgery for cervical spondylotic myelopathy were reviewed...
September 15, 2015: Spine
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