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JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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JOURNAL ARTICLE
Mitchell K Ng, Ariel Rodriguez, Aaron Lam, Ahmed Emara, Ian J Wellington, Nicholas U Ahn, Amrit S Khalsa, John K Houten, Ahmed Saleh, Afshin E Razi
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: The study aimed to (1) compare baseline demographics of patients undergoing surgery for SEA who were/were not readmitted; (2) identify risk factors for 90-day readmissions; and (3) quantify 90-day episode-of-care health care costs. BACKGROUND: Spinal epidural abscess (SEA), while rare, occurring ~2.5-5.1/10,000 admissions, may lead to permanent neurologic deficits and mortality. Definitive treatment often involves surgical intervention via decompression...
March 12, 2024: Clinical Spine Surgery
#3
Eric Ortlund, Chih-Yu Chen, Kristal Maner-Smith, Manoj Khadka, Jun Ahn, Xueyun Gulbin, Anna Ivanova, Eric Dammer, Nicholas Seyfried, David Bennett, Ihab Hajjar
The biology of individual lipid species and their relevance in Alzheimer's disease (AD) remains incompletely understood. We utilized non-targeted mass spectrometry to examine brain lipids variations across 316 post-mortem brains from participants in the Religious Orders Study (ROS) or Rush Memory and Aging Project (MAP) cohorts classified as either control, asymptomatic AD (AAD), or symptomatic AD (SAD) and integrated the lipidomics data with untargeted proteomic characterization on the same individuals. Lipid enrichment analysis and analysis of variance identified significantly lower abundance of lysophosphatidylethanolamine (LPE) and lysophosphatidylcholine (LPC) species in SAD than controls or AAD...
February 27, 2024: Research Square
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JOURNAL ARTICLE
Jerry Y Du, Karim Shafi, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, Randall E Marcus, Todd J Albert
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The purpose of this study is to compare the impact of anterior cervical decompression and fusion (ACDF) versus posterior cervical decompression and fusion (PCDF) for the treatment of acute traumatic central cord syndrome (CCS) on hospital episodes of care in terms of (1) cost, (2) length of hospital stay, and (3) discharge destination. SUMMARY OF BACKGROUND DATA: Acute traumatic CCS is the most common form of spinal cord injury in the United States...
March 1, 2024: Clinical Spine Surgery
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JOURNAL ARTICLE
Simon P Horslen, Yoon Son Ahn, Nicholas L Wood, Erin M Schnellinger, Katrina Gauntt, Meghan McDermott
Intestine remains the least frequently transplanted solid organ, although the survival and quality-of-life benefits of transplant to individuals with irreversible intestinal failure have been well demonstrated. The trend seen over the past 15 years of fewer listings and fewer transplants appears to be continuing, most noticeably in infants, children, and adolescents. There were only 146 additions to the intestine waiting list in 2022, and the proportion of adult candidates continues to increase, so that now 61% of the intestine waiting list are adult candidates...
February 2024: American Journal of Transplantation
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JOURNAL ARTICLE
Jerry Y Du, Karim Shafi, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, Randall E Marcus, Todd J Albert
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare elective single-level anterior cervical discectomy and fusion (ACDF) versus posterior cervical decompression and fusion (PCDF) for degenerative cervical myelopathy (DCM) in terms of (1) cost, (2) length of hospital stay, and (3) discharge destination in Medicare patients. A sub-analysis of potential cost drivers was also performed. BACKGROUND: In the era of value-based medicine, there is substantial interest in reducing the cost of care...
February 22, 2024: Clinical Spine Surgery
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JOURNAL ARTICLE
Nicole Naumann, Martina Rudelius, Johannes Lübke, Deborah Christen, Jakob Bresser, Karl Sotlar, Georgia Metzgeroth, Alice Fabarius, Wolf-Karsten Hofmann, Jens Panse, Hans-Peter Horny, Nicholas C P Cross, Andreas Reiter, Juliana Schwaab
Within our nationwide registry, we identified a KIT D816V mutation ( KIT D816Vpos.) in 280/299 (94%) patients with advanced systemic mastocytosis (AdvSM). Age, cytopenias and the presence of additional somatic mutations confer inferior overall survival (OS). However, little is known about the characteristics of KIT D816V-negative (D816Vneg. ) AdvSM. In 19 D816Vneg. patients, a combination of clinical, morphological and genetic features revealed three subgroups: (a) KIT D816H- or Y-positive SM ( KIT D816H/Ypos...
January 30, 2024: Cancers
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JOURNAL ARTICLE
Andrew C Strine, David I Chu, Megan A Brockel, Duncan T Wilcox, Gino J Vricella, Douglas E Coplen, Erica J Traxel, Rajeev Chaudhry, Brian A VanderBrink, Elizabeth B Yerkes, Yvonne Y Chan, Nicholas E Burjek, Rebecca S Zee, C D Anthony Herndon, Jennifer J Ahn, Paul A Merguerian, Bhalaajee Meenakshi-Sundaram, Adam J Rensing, Dominic Frimberger, Kyle O Rove
INTRODUCTION/BACKGROUND: Enhanced Recovery After Surgery (ERAS) is a fundamental shift in perioperative care that has consistently demonstrated an improved outcome for a wide variety of surgeries in adults but has only limited evidence in the pediatric population. OBJECTIVE: We aimed to assess the success with and barriers to implementation of ERAS in a prospective, multi-center study on patients undergoing complex lower urinary tract reconstruction. STUDY DESIGN: Centers were directed to implement an ERAS protocol using a multidisciplinary team and quality improvement methodologies...
December 30, 2023: Journal of Pediatric Urology
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JOURNAL ARTICLE
Gyutae Nam, Chihyun Hwang, Haeseong Jang, Nicholas Kane, Yoojin Ahn, Myung-Jun Kwak, Zheyu Luo, Tongtong Li, Min-Gyu Kim, Nian Liu, Meilin Liu
Rechargeable aqueous zinc-ion batteries (ZIBs) have emerged as an alternative to lithium-ion batteries due to their affordability and high level of safety. However, their commercialization is hindered by the low mass loading and irreversible structural changes of the cathode materials during cycling. Here, a disordered phase of a manganese nickel cobalt dioxide cathode material derived from wastewater via a coprecipitation process is reported. When used as the cathode for aqueous ZIBs , the developed electrode delivers 98% capacity retention at a current density of 0...
December 8, 2023: Small
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JOURNAL ARTICLE
Idris Hanidu, Ryan Johnson, Peter Ahorukomeye, Nicholas U Ahn
Introduction Hypercholesterolemia is known to be a major contributor to the morbidity associated with cardiovascular disease and has been hypothesized to result in degenerative changes to the spine through atherosclerosis of segmental lumbar vessels. The purpose of this study is to determine the relationship between hypercholesterolemia and degenerative lumbar spine conditions in a U.S. cohort. Methods A total of 30,461 participated in the 2018 Medicare Expenditure Panel Survey (MEPS). Of those, 1,063 subjects responded to whether a diagnosis of lumbar disorders with low back pain was present...
October 2023: Curēus
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JOURNAL ARTICLE
Paola Neri, Benjamin G Barwick, David Jung, Jonathan C Patton, Ranjan Maity, Ines Tagoug, Caleb K Stein, Remi Tilmont, Noemie Leblay, Sungwoo Ahn, Holly Lee, Seth J Welsh, Daniel L Riggs, Nicholas Stong, Erin Flynt, Anjan Thakurta, Jonathan J Keats, Sagar Lonial, P Leif Bergsagel, Lawrence H Boise, Nizar J Bahlis
Immunomodulatory Drugs (IMiDs) are a backbone therapy for multiple myeloma (MM). Despite their efficacy, most patients develop resistance, and the mechanism(s) are not fully defined. Here, we show that IMiD responses are directed by IMiD-dependent degradation of IKZF1 and IKZF3 that bind to enhancers necessary to sustain the expression of MYC and other myeloma oncogenes. IMiD treatment universally depleted chromatin-bound IKZF1, but eviction of P300 and BRD4 co-activators only occurred in IMiD-sensitive cells...
November 7, 2023: Blood cancer discovery
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JOURNAL ARTICLE
Seung Hyeon Bang, Carlos Gonzalez, Junhyeok Ahn, Nicholas Paine, Luis Sentis
In this paper, we introduce a new teen-sized humanoid platform dubbed DRACO 3, custom-built by Apptronik and altered for practical use by the Human Centered Robotics Laboratory at The University of Texas at Austin. The form factor of DRACO 3 is such that it can operate safely in human environments while reaching objects at human heights. To approximate the range of motion of humans, this robot features proximal actuation and mechanical artifacts to provide a high range of hip, knee, and ankle motions. In particular, rolling contact mechanisms on the lower body are incorporated using a proximal actuation principle to provide an extensive vertical pose workspace...
2023: Frontiers in Robotics and AI
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REVIEW
Matthew Quinn, Rory A Byrne, J Alex Albright, Edward Testa, Benjamin Ahn, Nicholas Lemme, Logan Petit, Brad Blankenhorn, Brett D Owens
PURPOSE: To examine the available literature to better understand the objective and patient-reported outcomes using peroneus longus tendon (PLT) autograft compared with more commonly used autografts, such as the quadrupled hamstring tendons (HT), in patients undergoing primary for anterior cruciate ligament reconstruction (ACLR). METHODS: A comprehensive search of published literature in PubMed, Web of Science, Cochrane Library, Ovid, and EMBASE databases was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
October 26, 2023: Arthroscopy
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JOURNAL ARTICLE
Green Ahn, Nicholas M Riley, Roarke A Kamber, Simon Wisnovsky, Salvador Moncayo von Hase, Michael C Bassik, Steven M Banik, Carolyn R Bertozzi
Targeted protein degradation can provide advantages over inhibition approaches in the development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to direct extracellular proteins to lysosomes. In this work, we used a genome-wide CRISPR knockout approach to identify modulators of LYTAC-mediated membrane protein degradation in human cells. We found that disrupting retromer genes improved target degradation by reducing LYTAC recycling to the plasma membrane...
October 20, 2023: Science
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JOURNAL ARTICLE
Mark Canney, Dilshani Induruwage, Mila Tang, Natalia Alencar de Pinho, Lee Er, Yinshan Zhao, Ognjenka Djurdjev, Yo Han Ahn, Rouven Behnisch, Viviane Calice-Silva, Nicholas C Chesnaye, Martin H de Borst, Laura M Dember, Janis Dionne, Natalie Ebert, Susanne Eder, Anthony Fenton, Masafumi Fukagawa, Susan L Furth, Wendy E Hoy, Takahiro Imaizumi, Kitty J Jager, Vivekanand Jha, Hee Gyung Kang, Chagriya Kitiyakara, Gert Mayer, Kook-Hwan Oh, Ugochi Onu, Roberto Pecoits-Filho, Helmut Reichel, Anna Richards, Franz Schaefer, Elke Schaeffner, Johannes B Scheppach, Laura Sola, Ifeoma Ulasi, Jinwei Wang, Ashok K Yadav, Jianzhen Zhang, Harold I Feldman, Maarten W Taal, Bénédicte Stengel, Adeera Levin
INTRODUCTION: Despite recognized geographic and sex-based differences in hemoglobin in the general population, these factors are typically ignored in patients with chronic kidney disease (CKD) in whom a single therapeutic range for hemoglobin is recommended. We sought to compare the distribution of hemoglobin across international nondialysis CKD populations and evaluate predictors of hemoglobin. METHODS: In this cross-sectional study, hemoglobin distribution was evaluated in each cohort overall and stratified by sex and estimated glomerular filtration rate (eGFR)...
October 2023: KI Reports
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JOURNAL ARTICLE
Nicholas C Bruno, Ronita Mathias, Young Joo Lee, Guanghui Zhu, Yun-Ho Ahn, Neel D Rangnekar, J R Johnson, Scott Hoy, Irene Bechis, Andrew Tarzia, Kim E Jelfs, Benjamin A McCool, Ryan Lively, M G Finn
The thermal distillation of crude oil mixtures is an energy-intensive process, accounting for nearly 1% of global energy consumption. Membrane-based separations are an appealing alternative or tandem process to distillation due to intrinsic energy efficiency advantages. We developed a family of spirocyclic polytriazoles from structurally diverse monomers for membrane applications. The resulting polymers were prepared by a convenient step-growth method using copper-catalysed azide-alkyne cycloaddition, providing very fast reaction rates, high molecular weights and solubilities in common organic solvents and non-interconnected microporosity...
October 16, 2023: Nature Materials
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JOURNAL ARTICLE
Sourav K Bose, John D Stratigis, Nicholas Ahn, Jennifer Pogoriler, Holly L Hedrick, Natalie E Rintoul, Emily A Partridge, Alan W Flake, Nahla Khalek, Julianna Gebb, Christina Paidas Teefey, Shelly Soni, Ryoko Hamaguchi, Julie Moldenhauer, N Scott Adzick, William H Peranteau
INTRODUCTION: Fetuses with large lung lesions including congenital cystic adenomatoid malformations (CCAMs) are at risk for cardiopulmonary compromise. Prenatal maternal betamethasone and cyst drainage for micro- and macrocystic lesions respectively have improved outcomes yet some lesions remain large and require resection before birth (open fetal surgery, OFS), at delivery via an Ex Utero Intrapartum Treatment (EXIT), or immediately post cesarean section (section-to-resection, STR). We sought to compare prenatal characteristics and outcomes in fetuses undergoing OFS, EXIT, or STR to inform decision-making and prenatal counseling...
September 9, 2023: Journal of Pediatric Surgery
#18
JOURNAL ARTICLE
Nicholas Humniski, Justin S Ahn, Rahim Manji, Daniel J Kim
No abstract text is available yet for this article.
June 19, 2023: Journal of Emergency Medicine
#19
JOURNAL ARTICLE
Kempland C Walley, Nicholas R Farrar, Aditya Muralidharan, Demetri A Monovoukas, Jack Eichman, Michael P Klueh, Anthony N Baumann, Aaron M Perdue, Mark E Hake, Jaimo Ahn
Disuse osteopenia is a well-recognized consequence of prolonged physical inactivity, but its rate after orthopaedic injuries necessitating non-weight-bearing is not well studied. The purpose of this study was to estimate the rate of disuse osteopenia at the lumbar spine and proximal femur in patients with lower extremity trauma admitted to the hospital. We performed a retrospective chart review of patients with lower extremity trauma with a period of strict non-weight-bearing between completion of two computed tomography (CT) scans...
October 7, 2023: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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JOURNAL ARTICLE
Ashok Agarwal, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid Hamoda, Gianmaria Salvio, Florence Boitrelle, Ahmed M Harraz, Ramy Abou Ghayda, Parviz Kavoussi, Murat Gül, Tuncay Toprak, Giorgio Ivan Russo, Damayanthi Durairajanayagam, Amarnath Rambhatla, Ponco Birowo, Rossella Cannarella, Nguyen Ho Vinh Phuoc, Armand Zini, Mohamed Arafa, Christine Wyns, Kelton Tremellen, Selçuk Sarıkaya, Sheena Lewis, Donald P Evenson, Edmund Ko, Aldo E Calogero, Fahmi Bahar, Marlon Martínez, Rafael F Ambar, Giovanni M Colpi, Mustafa Emre Bakircioglu, Ralf Henkel, Hussein Kandil, Ege Can Serefoglu, Abdullah Alfakhri, Akira Tsujimura, Alireza Kheradmand, Angelo Marino, Aram Adamyan, Birute Zilaitiene, Cevahir Ozer, Edoardo Pescatori, Paraskevi Vogiatzi, Gian Maria Busetto, Giancarlo Balercia, Haitham Elbardisi, Hamed Akhavizadegan, Hesamoddin Sajadi, Hisanori Taniguchi, Hyun Jun Park, Israel Maldonado Rosas, Mohamed Al-Marhoon, Mohammad Ali Sadighi Gilani, Naif Alhathal, Nguyen Quang, Germar-Michael Pinggera, Priyank Kothari, Sava Micic, Sheryl Homa, Tran Quang Tien Long, Wael Zohdy, Widi Atmoko, Wael Ibrahim, Marjan Sabbaghian, Saad Mohammed Abumelha, Eric Chung, Muhammet Rasit Ugur, Mehmet Serkan Ozkent, Osama Selim, Mahsa Darbandi, Shinichiro Fukuhara, Mounir Jamali, Jean de la Rosette, Shinnosuke Kuroda, Ryan P Smith, Aykut Baser, Arif Kalkanli, Nicholas N Tadros, Kaan Aydos, Tiago Cesar Mierzwa, Kareim Khalafalla, Vineet Malhotra, Mohamad Moussa, Federica Finocchi, Rinaldo Indra Rachman, Carlo Giulioni, Tomer Avidor-Reiss, Oguzhan Kahraman, Gökhan Çeker, Cătălina Zenoaga-Barbăroşie, Trenton L Barrett, Mehmet Yilmaz, Ates Kadioglu, Sunil Jindal, Huda Omran, Kadir Bocu, Vilvapathy Senguttuvan Karthikeyan, Giorgio Franco, Jesús Fernando Solorzano, Ranjit B Vishwakarma, Eko Arianto, Nicolas Garrido, Divyanu Jain, Nazim Gherabi, Ioannis Sokolakis, Ayad Palani, Gokhan Calik, Deniz Kulaksiz, Vaida Simanaviciene, Mara Simopoulou, Nur Dokuzeylül Güngör, Gideon Blecher, Marco Falcone, Davor Jezek, Mirko Preto, Edouard Amar, Tan V Le, Sun Tae Ahn, Andri Rezano, Keerti Singh, Lucia Rocco, Missy Savira, Osvaldo Rajmil, Sara Darbandi, Emrullah Sogutdelen, Luca Boeri, Guadalupe Hernández, Lukman Hakim, Yoshiharu Morimoto, Andrian Japari, Nikolaos Sofikitis, Baris Altay, Asli Metin Mahmutoglu, Manaf Al Hashimi, Imad Ziouziou, Christina Anagnostopoulou, Haocheng Lin, Rupin Shah
PURPOSE: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches...
August 24, 2023: World Journal of Men's Health
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