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Ronald lehman

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https://www.readbyqxmd.com/read/27847678/a-systematic-review-of-treatment-strategies-for-degenerative-lumbar-spine-fusion-surgery-in-patients-with-osteoporosis
#1
Charla R Fischer, Gregory Hanson, Melinda Eller, Ronald A Lehman
PURPOSE: To evaluate the current evidence in the literature on treatment strategies for degenerative lumbar spine fusion in patients with osteoporosis. METHODS: A systematic review of the literature from 1950 to 2015. RESULTS: The review of the literature yielded 15 studies on the effect of treatment options for osteoporosis on lumbar fusion rates. This study evaluated only degenerative lumbar spine conditions and excluded deformity patients...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27605692/reversible-intraoperative-neurophysiologic-monitoring-alerts-in-patients-undergoing-arthrodesis-for-adolescent-idiopathic-scoliosis-what-are-the-outcomes-of-surgery
#2
Amer F Samdani, James T Bennett, Robert J Ames, Jahangir K Asghar, Giuseppe Orlando, Joshua M Pahys, Burt Yaszay, Firoz Miyanji, Baron S Lonner, Ronald A Lehman, Peter O Newton, Patrick J Cahill, Randal R Betz
BACKGROUND: Confidence in intraoperative neurophysiologic monitoring (IONM) data can allow scoliosis surgeons to proceed with surgery even after a monitoring alert, assuming the recovery of signals. We sought to determine the outcomes of surgical treatment of adolescent idiopathic scoliosis (AIS) after a notable IONM alert. METHODS: We identified 676 patients who underwent arthrodesis with use of IONM for the treatment of AIS. The patients were divided into 2 cohorts: those who experienced a lower-extremity IONM alert and those who did not...
September 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27543397/return-to-play-after-cervical-disc-surgery
#3
REVIEW
Daniel G Kang, Justin C Anderson, Ronald A Lehman
Criteria for return to sports and athletic activities after cervical spine surgery are unclear. There is limited literature regarding the outcomes and optimal criteria. Determining return to play criteria remains a challenge and continues to depend on the experience and good judgment of the treating surgeon. There is strong consensus in the literature, despite lack of evidence-based data, that athletes after single-level anterior cervical discectomy and fusion (ACDF) may safely return to collision and high-velocity sports...
October 2016: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27398621/the-genetic-architecture-of-type-2-diabetes
#4
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups...
August 4, 2016: Nature
https://www.readbyqxmd.com/read/27356620/prosaposin-is-a-regulator-of-progranulin-levels-and-oligomerization
#5
Alexandra M Nicholson, NiCole A Finch, Marcio Almeida, Ralph B Perkerson, Marka van Blitterswijk, Aleksandra Wojtas, Basar Cenik, Sergio Rotondo, Venette Inskeep, Laura Almasy, Thomas Dyer, Juan Peralta, Goo Jun, Andrew R Wood, Timothy M Frayling, Christian Fuchsberger, Sharon Fowler, Tanya M Teslovich, Alisa K Manning, Satish Kumar, Joanne Curran, Donna Lehman, Goncalo Abecasis, Ravindranath Duggirala, Cyril Pottier, Haaris A Zahir, Julia E Crook, Anna Karydas, Laura Mitic, Ying Sun, Dennis W Dickson, Guojun Bu, Joachim Herz, Gang Yu, Bruce L Miller, Shawn Ferguson, Ronald C Petersen, Neill Graff-Radford, John Blangero, Rosa Rademakers
Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic for multiple disorders. To uncover novel PGRN regulators, we linked whole-genome sequence data from 920 individuals with plasma PGRN levels and identified the prosaposin (PSAP) locus as a new locus significantly associated with plasma PGRN levels...
2016: Nature Communications
https://www.readbyqxmd.com/read/27343731/operative-management-of-complex-lumbosacral-dissociations-in-combat-injuries
#6
Peter M Formby, Scott C Wagner, Daniel G Kang, Gregory S Van Blarcum, Ronald A Lehman
BACKGROUND CONTEXT: As war injury patterns have changed throughout Operations Iraqi and Enduring Freedom (OIF and OEF), a relative increase in the incidence of complex lumbosacral dissociation (LSD) injuries has been noted. Lumbosacral dissociation injuries are an anatomical separation of the spinal column from the pelvis, and represent a manifestation of severe, high-energy trauma. PURPOSE: This study aimed to assess the clinical outcomes of combat-related LSD injuries at a mean of 7 years following operative treatment...
June 22, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27063497/decision-making-for-upper-instrumented-vertebra-in-thoracolumbar-lumbar-adolescent-idiopathic-scoliosis-can-we-stop-below-the-end-vertebra
#7
COMMENT
Comron Saifi, Daniel G Kang, Ronald A Lehman
Sudo H, Kaneda K, Shono Y, Iwasaki N. Selection of the upper vertebra to be instrumented in the treatment of thoracolumbar and lumbar adolescent idiopathic scoliosis by anterior correction and fusion surgery using dual-rod instrumentation: a minimum 12-year follow-up study. Spine J. 2016:16:281-7 (in this issue).
March 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26949033/persistent-axial-neck-pain-after-cervical-disc-arthroplasty-a-radiographic-analysis
#8
Scott C Wagner, Peter M Formby, Daniel G Kang, Gregory S Van Blarcum, John P Cody, Robert W Tracey, Ronald A Lehman
BACKGROUND CONTEXT: There is very little literature examining optimal radiographic parameters for placement of cervical disc arthroplasty (CDA), nor is there substantial evidence evaluating the relationship between persistent postoperative neck pain and radiographic outcomes. PURPOSE: We set out to perform a single-center evaluation of the radiographic outcomes, including associated complications, of CDA. DESIGN: This is a retrospective review...
July 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26877156/tissue-engineering-advances-in-spine-surgery
#9
Melvin C Makhni, Jon-Michael E Caldwell, Comron Saifi, Charla R Fischer, Ronald A Lehman, Lawrence G Lenke, Francis Y Lee
Autograft, while currently the gold standard for bone grafting, has several significant disadvantages including limited supply, donor site pain, hematoma formation, nerve and vascular injury, and fracture. Bone allografts have their own disadvantages including reduced osteoinductive capability, lack of osteoprogenitor cells, immunogenicity and risk of disease transmission. Thus demand exists for tissue-engineered constructs that can produce viable bone while avoiding the complications associated with human tissue grafts...
March 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/26639623/reoperation-after-in-theater-combat-spine-surgery
#10
Peter M Formby, Scott C Wagner, Daniel G Kang, Gregory S Van Blarcum, Alfred J Pisano, Ronald A Lehman
BACKGROUND CONTEXT: The ideal timing of surgical decompression or stabilization following combat-related spine injury remains unclear. PURPOSE: The study aims to determine the etiology and factors related to reoperation following evacuation to the United States after undergoing in-theater spine surgery. STUDY DESIGN: This is a retrospective analysis. PATIENT SAMPLE: The sample includes 13 patients with combat-related spine injuries undergoing revision spine surgery...
March 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26116849/extremity-war-injuries-ix-reducing-disability-within-the-military
#11
Col Romney C Andersen, Andrew H Schmidt, Capt Brian T Fitzgerald, Lcdr Scott M Tintle, Maj Melvin D Helgeson, Ltc Ronald A Lehman, Col Jeffrey N Davila, Benjamin K Potter, Maj Travis C Burns, Marc F Swiontkowski, Col James R Ficke
Extremity War Injury Symposium IX focused on reducing disability within the military, centering on cartilage defects, amputations, and spinal cord injury. Many areas of upper and lower extremity trauma and disability were discussed, including segmental nerve injuries, upper extremity allotransplantation, and the importance of patient-reported functional outcomes compared with the traditionally reported measures. Strategic planning addressed progression toward clinical solutions by setting clear objectives and goals and outlining pathways to address the "translation gap" that often prevents bridging of basic science to clinical application...
August 2015: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/26020848/outcomes-after-operative-management-of-combat-related-low-lumbar-burst-fractures
#12
Peter M Formby, Scott C Wagner, Alfred J Pisano, Gregory S Van Blarcum, Daniel G Kang, Ronald A Lehman
STUDY DESIGN: Retrospective review. OBJECTIVE: Report the 2-year operative and clinical outcomes of these service members with low lumbar fractures. SUMMARY OF BACKGROUND DATA: The majority of spinal fractures occur at the thoracolumbar level, with fractures caudal to L2 accounting for only 1% of spine fractures. A previous report from this institution regarding combat-related spine burst fractures documented an increased incidence of low lumbar burst fractures in injured service members...
September 15, 2015: Spine
https://www.readbyqxmd.com/read/25939103/characteristics-of-combat-related-spine-injuries-a-review-of-recent-literature
#13
Joshua D Bernstock, Connor M Caples, Scott C Wagner, Daniel G Kang, Ronald A Lehman
Injuries to the spinal column in combat casualties sustained during the conflicts in Iraq and Afghanistan are common, and the highest in reported wartime history. High-energy blast mechanisms from improved explosive devices have resulted in complex polytrauma and injury patterns, which are often markedly different from those injuries encountered in civilian trauma. Herein, we review the most current literature with regard to the distinct types of combat-related spine injuries/concomitant comorbidities sustained in Operations Enduring Freedom, Iraqi Freedom and New Dawn...
May 2015: Military Medicine
https://www.readbyqxmd.com/read/25808687/management-of-osteoporosis-in-spine-surgery
#14
REVIEW
Ronald A Lehman, Daniel Gene Kang, Scott Cameron Wagner
Osteoporosis is a burgeoning clinical problem that is characterized by decreased bone strength and density. It predisposes patients to fragility fractures and debilitating spine deformities. Several complications are associated with spine surgery in patients with osteoporosis, and there is currently no treatment algorithm to guide the spine surgeon. A multidisciplinary approach to treatment of patients with osteoporosis and spine deformity or fracture is encouraged, and preoperative planning is crucial for successful surgical outcomes...
April 2015: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/25771755/biomechanical-stability-of-transverse-connectors-in-the-setting-of-a-thoracic-pedicle-subtraction-osteotomy
#15
Ronald A Lehman, Daniel G Kang, Scott C Wagner, Haines Paik, Mario J Cardoso, Joshua D Bernstock, Anton E Dmitriev
BACKGROUND CONTEXT: Transverse connectors (TCs) are often used to improve the rigidity of posterior spinal instrumentation as previous investigations have suggested that TCs enhance torsional rigidity in long-segment thoracic constructs. Posterior osteotomies, such as pedicle subtraction osteotomy (PSO), are used in severe thoracic deformities and provide a significant amount of correction; as a consequence, however, PSOs also induce three-column spinal instability. In theory, augmentation of longitudinal constructs with TC after a thoracic PSO may provide additional rigidity, but the concept has not been previously evaluated...
July 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/25662524/prevalence-of-hypovitaminosis-d-and-its-association-with-comorbidities-of-childhood-obesity
#16
Ronald Williams, Marsha Novick, Erik Lehman
PURPOSE: Our study sought to further delineate the prevalence of hypovitaminosis D and its relationship to comorbidities of childhood obesity. METHODS: We conducted a retrospective chart review from 155 obese children aged 5 to 19 years who attended the Penn State Children’s Hospital Pediatric Multidisciplinary Weight Loss Program from November 2009 through November 2010. We determined the incidence of hypovitaminosis D and examined its association with comorbidities including elevated blood pressure, diabetes, acanthosis nigricans, depression, hyperlipidemia, hyperinsulinemia, and abnormal liver function test results, as well as age, sex, and geographic location...
2014: Permanente Journal
https://www.readbyqxmd.com/read/25643379/operative-treatment-of-new-onset-radiculopathy-secondary-to-combat-injury
#17
Scott C Wagner, Gregory S Van Blarcum, Daniel G Kang, Ronald A Lehman
We set out to describe combat-related spine trauma over a 10-year period, and thereby determine the frequency of new onset radiculopathy secondary to injuries sustained in support of combat operations. We performed a retrospective analysis of a surgical database at three military institutions. Patients undergoing spine surgery following a combat-related injury in Afghanistan or Iraq between July 2003 and July 2013 were evaluated. We identified 105 patients with combat-related (Operations Enduring and Iraqi Freedom) spine trauma requiring operative intervention...
February 2015: Military Medicine
https://www.readbyqxmd.com/read/25637469/intrasite-vancomycin-powder-for-the-prevention-of-surgical-site-infection-in-spine-surgery-a-systematic-literature-review
#18
REVIEW
Daniel G Kang, Terrence F Holekamp, Scott C Wagner, Ronald A Lehman
BACKGROUND CONTEXT: Deep surgical site infections (SSIs) following spinal surgery are a significant burden to the patient, patient's family, and the health-care system. Because of increasing pressures to reduce SSIs and control costs, some spine surgeons have begun placing lyophilized vancomycin powder directly into the surgical wound at the conclusion of the procedure. However, the literature supporting this practice remains limited. PURPOSE: To review the current literature examining the use of prophylactic intrasite vancomycin powder to control SSIs in spinal surgery and determine if any standard recommendations can be made...
April 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/25568392/pulmonary-function-following-adult-spinal-deformity-surgery-minimum-two-year-follow-up
#19
Ronald A Lehman, Daniel G Kang, Lawrence G Lenke, Jeremy J Stallbaumer, Brenda A Sides
BACKGROUND: The literature regarding pulmonary function in adult patients with spinal deformity is limited, and the effect of spinal deformity surgery on pulmonary function has not been clearly understood. We hypothesized that adult patients with spinal deformity who had preoperative pulmonary impairment (a percent-predicted value of <65% forced expiratory volume in one second [FEV1] as measured by pulmonary function test) or who were undergoing revision surgery may be at risk for exacerbated decline in pulmonary function...
January 7, 2015: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/25150917/bone-morphogenetic-protein-use-in-the-cervical-spine-questions-about-safety-and-effectiveness
#20
COMMENT
Scott C Wagner, Ronald A Lehman, John M Rhee
No abstract text is available yet for this article.
September 1, 2014: Spine Journal: Official Journal of the North American Spine Society
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