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Adam j. Schell

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https://www.readbyqxmd.com/read/26305897/genome-wide-association-and-trans-ethnic-meta-analysis-for-advanced-diabetic-kidney-disease-family-investigation-of-nephropathy-and-diabetes-find
#1
Sudha K Iyengar, John R Sedor, Barry I Freedman, W H Linda Kao, Matthias Kretzler, Benjamin J Keller, Hanna E Abboud, Sharon G Adler, Lyle G Best, Donald W Bowden, Allison Burlock, Yii-Der Ida Chen, Shelley A Cole, Mary E Comeau, Jeffrey M Curtis, Jasmin Divers, Christiane Drechsler, Ravi Duggirala, Robert C Elston, Xiuqing Guo, Huateng Huang, Michael Marcus Hoffmann, Barbara V Howard, Eli Ipp, Paul L Kimmel, Michael J Klag, William C Knowler, Orly F Kohn, Tennille S Leak, David J Leehey, Man Li, Alka Malhotra, Winfried März, Viji Nair, Robert G Nelson, Susanne B Nicholas, Stephen J O'Brien, Madeleine V Pahl, Rulan S Parekh, Marcus G Pezzolesi, Rebekah S Rasooly, Charles N Rotimi, Jerome I Rotter, Jeffrey R Schelling, Michael F Seldin, Vallabh O Shah, Adam M Smiles, Michael W Smith, Kent D Taylor, Farook Thameem, Denyse P Thornley-Brown, Barbara J Truitt, Christoph Wanner, E Jennifer Weil, Cheryl A Winkler, Philip G Zager, Robert P Igo, Robert L Hanson, Carl D Langefeld
Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry...
August 2015: PLoS Genetics
https://www.readbyqxmd.com/read/24998914/bone-marrow-adipose-tissue-is-an-endocrine-organ-that-contributes-to-increased-circulating-adiponectin-during-caloric-restriction
#2
William P Cawthorn, Erica L Scheller, Brian S Learman, Sebastian D Parlee, Becky R Simon, Hiroyuki Mori, Xiaomin Ning, Adam J Bree, Benjamin Schell, David T Broome, Sandra S Soliman, Jenifer L DelProposto, Carey N Lumeng, Aditi Mitra, Sandeep V Pandit, Katherine A Gallagher, Joshua D Miller, Venkatesh Krishnan, Susanta K Hui, Miriam A Bredella, Pouneh K Fazeli, Anne Klibanski, Mark C Horowitz, Clifford J Rosen, Ormond A MacDougald
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT...
August 5, 2014: Cell Metabolism
https://www.readbyqxmd.com/read/21616665/triazoles-as-%C3%AE-secretase-modulators
#3
Christian Fischer, Susan L Zultanski, Hua Zhou, Joey L Methot, W Colby Brown, Dawn M Mampreian, Adam J Schell, Sanjiv Shah, Hugh Nuthall, Bethany L Hughes, Nadja Smotrov, Candia M Kenific, Jonathan C Cruz, Deborah Walker, Melanie Bouthillette, George N Nikov, Dan F Savage, Valentina V Jeliazkova-Mecheva, Damaris Diaz, Alexander A Szewczak, Nathan Bays, Richard E Middleton, Benito Munoz, Mark S Shearman
Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for olefins commonly found in non-acid GSMs. 1,2,3-C-aryl-triazoles were identified as suitable replacements which exhibited good modulation of γ-secretase activity, excellent pharmacokinetics and good central lowering of Aβ42 in Sprague-Dawley rats.
July 1, 2011: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/19118815/infection-triggered-familial-or-recurrent-cases-of-acute-necrotizing-encephalopathy-caused-by-mutations-in-a-component-of-the-nuclear-pore-ranbp2
#4
Derek E Neilson, Mark D Adams, Caitlin M D Orr, Deborah K Schelling, Robert M Eiben, Douglas S Kerr, Jane Anderson, Alexander G Bassuk, Ann M Bye, Anne-Marie Childs, Antonia Clarke, Yanick J Crow, Maja Di Rocco, Christian Dohna-Schwake, Gregor Dueckers, Alfonso E Fasano, Artemis D Gika, Dimitris Gionnis, Mark P Gorman, Padraic J Grattan-Smith, Annette Hackenberg, Alice Kuster, Markus G Lentschig, Eduardo Lopez-Laso, Elysa J Marco, Sotiria Mastroyianni, Julie Perrier, Thomas Schmitt-Mechelke, Serenella Servidei, Angeliki Skardoutsou, Peter Uldall, Marjo S van der Knaap, Karrie C Goglin, David L Tefft, Cristin Aubin, Philip de Jager, David Hafler, Matthew L Warman
Acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy that can occur in otherwise healthy children after common viral infections such as influenza and parainfluenza. Most ANE is sporadic and nonrecurrent (isolated ANE). However, we identified a 7 Mb interval containing a susceptibility locus (ANE1) in a family segregating recurrent ANE as an incompletely penetrant, autosomal-dominant trait. We now report that all affected individuals and obligate carriers in this family are heterozygous for a missense mutation (c...
January 2009: American Journal of Human Genetics
https://www.readbyqxmd.com/read/17908558/a-conserved-role-for-phosphatidylinositol-3-kinase-but-not-akt-signaling-in-mitochondrial-adaptations-that-accompany-physiological-cardiac-hypertrophy
#5
Brian T O'Neill, Jaetaek Kim, Adam R Wende, Heather A Theobald, Joseph Tuinei, Jonathan Buchanan, Aili Guo, Vlad G Zaha, Don K Davis, John C Schell, Sihem Boudina, Benjamin Wayment, Sheldon E Litwin, Tetsuo Shioi, Seigo Izumo, Morris J Birnbaum, E Dale Abel
Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1alpha and increased fatty acid oxidative (FAO) capacity. It is widely accepted that phosphatidylinositol 3-kinase (PI3K) signaling to Akt1 is required for physiological cardiac growth. However, the signaling pathways that coordinate physiological hypertrophy and metabolic remodeling are incompletely understood. We show here that activation of PI3K is sufficient to increase myocardial FAO capacity and that inhibition of PI3K signaling prevents mitochondrial adaptations in response to physiological hypertrophic stimuli despite increased expression of PGC-1alpha...
October 2007: Cell Metabolism
https://www.readbyqxmd.com/read/15158627/whole-brain-radiation-therapy-with-or-without-stereotactic-radiosurgery-boost-for-patients-with-one-to-three-brain-metastases-phase-iii-results-of-the-rtog-9508-randomised-trial
#6
RANDOMIZED CONTROLLED TRIAL
David W Andrews, Charles B Scott, Paul W Sperduto, Adam E Flanders, Laurie E Gaspar, Michael C Schell, Maria Werner-Wasik, William Demas, Janice Ryu, Jean-Paul Bahary, Luis Souhami, Marvin Rotman, Minesh P Mehta, Walter J Curran
BACKGROUND: Brain metastases occur in up to 40% of all patients with systemic cancer. We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG). METHODS: Patients with one to three newly diagnosed brain metastases were randomly allocated either whole brain radiation therapy (WBRT) or WBRT followed by stereotactic radiosurgery boost. Patients were stratified by number of metastases and status of extracranial disease...
May 22, 2004: Lancet
https://www.readbyqxmd.com/read/11494337/role-of-canine-basal-cells-in-postnatal-prostatic-development-induction-of-hyperplasia-and-sex-hormone-stimulated-growth-and-the-ductal-origin-of-carcinoma
#7
I Leav, K H Schelling, J Y Adams, F B Merk, J Alroy
BACKGROUND: The canine prostate has often been proposed as a model for abnormal growth of the human gland. Hyperplasia of the prostate is common in aging men and has been estimated to be present in 100% of old intact dogs. While prostatic carcinoma is common in older men, it appears to be rare in dogs and unlike the disease in humans, it occurs with relatively high frequency in castrated animals. Since basal cells are thought to be key participants in normal and abnormal growth of the human gland, we used immunohistochemistry to investigate the role that they may play in canine prostatic development, the evolution of hyperplasia and carcinoma, and the effects of sex hormones on these cells...
August 1, 2001: Prostate
https://www.readbyqxmd.com/read/11351344/role-of-canine-basal-cells-in-prostatic-post-natal-development-induction-of-hyperplasia-sex-hormone-stimulated-growth-and-the-ductal-origin-of-carcinoma
#8
I Leav, K H Schelling, J Y Adams, F B Merk, J Alroy
BACKGROUND: The canine prostate has often been proposed as a model for abnormal growth of the human gland. Hyperplasia of the prostate is common in aging men and has been estimated to be present in 100% of old intact dogs. While prostatic carcinoma is common in older men it appears to be rare in dogs and unlike the disease in humans it occurs with relatively high frequency in castrated animals. Since basal cells are thought to be key participants in normal and abnormal growth of the human gland, we used immunohistochemistry to investigate the role that they may play in canine prostatic development, the evolution of hyperplasia and carcinoma, and the effects of sex hormones on these cells...
May 15, 2001: Prostate
https://www.readbyqxmd.com/read/9675902/transcription-of-the-arabidopsis-cpd-gene-encoding-a-steroidogenic-cytochrome-p450-is-negatively-controlled-by-brassinosteroids
#9
J Mathur, G Molnár, S Fujioka, S Takatsuto, A Sakurai, T Yokota, G Adam, B Voigt, F Nagy, C Maas, J Schell, C Koncz, M Szekeres
The Arabidopsis CPD gene encodes a cytochrome P450 steroid side-chain hydroxylase (CYP90) that plays an essential role in the biosynthesis of the plant hormone brassinolide. Expression of the CPD gene is confined to cotyledons and leaf primordia in etiolated seedlings and detectable in the adaxial parenchyma of expanding leaves in light-grown plants. Transcription of the CPD gene is not affected by the plant growth factors auxin, ethylene, gibberellin, cytokinin, jasmonic acid and salicylic acid, but is specifically down-regulated by brassinolide in both dark and light...
June 1998: Plant Journal: for Cell and Molecular Biology
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