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John M. Rhee

Hermine H Maes, Elizabeth Prom-Wormley, Lindon J Eaves, Soo Hyun Rhee, John K Hewitt, Susan Young, Robin Corley, Matt McGue, William G Iacono, Lisa Legrand, Di Samek, E Lenn Murrelle, Judy L Silberg, Donna Miles, Richard M Schieken, Gaston P Beunen, Martine Thomis, Richard J Rose, Danielle M Dick, Dorret I Boomsma, Meike Bartels, Jacqueline M Vink, Paul Lichtenstein, Victoria White, Jaakko Kaprio, Michael C Neale
INTRODUCTION: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation across adolescence. METHODS: Mega-analysis of pooled genetically informative data on smoking initiation was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N=19 313 pairs) between age 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the US, Europe and Australia RESULTS: Although prevalences differed between samples, twin correlations did not, suggesting similar etiology of smoking initiation across developed countries...
November 2, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Azadeh A T Borojeni, Dennis O Frank-Ito, Julia S Kimbell, John S Rhee, Guilherme J M Garcia
Virtual surgery planning based on computational fluid dynamics (CFD) simulations has the potential to improve surgical outcomes for nasal airway obstruction (NAO) patients, but the benefits of virtual surgery planning must outweigh the risks of radiation exposure. Cone beam computed tomography (CBCT) scans represent an attractive imaging modality for virtual surgery planning due to lower costs and lower radiation exposures compared with conventional CT scans. However, to minimize the radiation exposure, the CBCT sinusitis protocol sometimes images only the nasal cavity, excluding the nasopharynx...
August 15, 2016: International Journal for Numerical Methods in Biomedical Engineering
Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, John J Sim, Kevin Harley, Juan Carlos Ayus, Alpesh N Amin, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Sodium disarrays are common in peritoneal dialysis (PD) patients, and may be associated with adverse outcomes in this population. However, few studies of limited sample size have examined the association of serum sodium with mortality in PD patients, with inconsistent results. We hypothesized that both hypo- and hypernatremia are associated with higher death risk in a nationally representative cohort of US PD patients. METHODS: We sought to examine the association of serum sodium over time and mortality among 4687 adult incident PD patients from a large US dialysis organization who underwent one or more serum sodium measurements within the first 3 months of dialysis over January 2007 to December 2011...
June 29, 2016: Nephrology, Dialysis, Transplantation
David E Vizurraga, John M Rhee, Timothy C Borden, Ashton S Mansour
STUDY DESIGN: Radiologic analysis. OBJECTIVE: The objective was to compare C2 pedicle diameter and screw feasibility on reconstructed axial computed tomography (CT) cuts created "Inline" (IL) with the intended pedicle screw tract versus unaltered "Standard" (STD) axial cuts. BACKGROUND DATA: Axial CT cuts through the C2 pedicle are commonly evaluated when planning pedicle screw fixation as medial aberrancies of the vertebral artery can significantly narrow pedicle diameter...
June 27, 2016: Clinical Spine Surgery
Anupriya Dayal, John S Rhee, Guilherme J M Garcia
OBJECTIVES: This computational study aims to (1) use virtual surgery to theoretically investigate the maximum possible change in nasal aerodynamics after turbinate surgery, (2) quantify the relative contributions of the middle and inferior turbinates to nasal resistance and air conditioning, and (3) quantify to what extent total turbinectomy impairs the nasal air-conditioning capacity. STUDY DESIGN: Virtual surgery and computational fluid dynamics. SETTING: Academic tertiary medical center...
September 2016: Otolaryngology—Head and Neck Surgery
Guilherme J M Garcia, Benjamin M Hariri, Ruchin G Patel, John S Rhee
The relationship between nasal resistance (R) and airspace minimal cross-sectional area (mCSA) remains unclear. After the introduction of acoustic rhinometry, many otolaryngologists believed that mCSA measurements would correlate with subjective perception of nasal airway obstruction (NAO), and thus could provide an objective measure of nasal patency to guide therapy. However, multiple studies reported a low correlation between mCSA and subjective nasal patency, and between mCSA and R. This apparent lack of correlation between nasal form and function has been a long-standing enigma in the field of rhinology...
June 14, 2016: Journal of Biomechanics
Adam Schell, John M Rhee, Abigail Allen, Lindsay Andras, Feifei Zhou
BACKGROUND CONTEXT: Gorham disease is a rare osteolytic condition, with only 17 reported cases primarily affecting the cervical spine. PURPOSE: We report the case of a 31-year-old woman with severe kyphotic instability and myelopathy of the upper cervical spine secondary to massive osteolysis of the posterior elements. The surgical management, clinical outcome, and review of the relevant literature are discussed. STUDY DESIGN: This is a case report and a literature review...
July 2016: Spine Journal: Official Journal of the North American Spine Society
Rajiv Saran, Yi Li, Bruce Robinson, Kevin C Abbott, Lawrence Y C Agodoa, John Ayanian, Jennifer Bragg-Gresham, Rajesh Balkrishnan, Joline L T Chen, Elizabeth Cope, Paul W Eggers, Daniel Gillen, Debbie Gipson, Susan M Hailpern, Yoshio N Hall, Kevin He, William Herman, Michael Heung, Richard A Hirth, David Hutton, Steven J Jacobsen, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Yee Lu, Miklos Z Molnar, Hal Morgenstern, Brahmajee Nallamothu, Danh V Nguyen, Ann M O'Hare, Brett Plattner, Ronald Pisoni, Friedrich K Port, Panduranga Rao, Connie M Rhee, Ankit Sakhuja, Douglas E Schaubel, David T Selewski, Vahakn Shahinian, John J Sim, Peter Song, Elani Streja, Manjula Kurella Tamura, Francesca Tentori, Sarah White, Kenneth Woodside, Richard A Hirth
No abstract text is available yet for this article.
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Shohei Koyama, Esra A Akbay, Yvonne Y Li, Amir R Aref, Ferdinandos Skoulidis, Grit S Herter-Sprie, Kevin A Buczkowski, Yan Liu, Mark M Awad, Warren L Denning, Lixia Diao, Jing Wang, Edwin R Parra-Cuentas, Ignacio I Wistuba, Margaret Soucheray, Tran Thai, Hajime Asahina, Shunsuke Kitajima, Abigail Altabef, Jillian D Cavanaugh, Kevin Rhee, Peng Gao, Haikuo Zhang, Peter E Fecci, Takeshi Shimamura, Matthew D Hellmann, John V Heymach, F Stephen Hodi, Gordon J Freeman, David A Barbie, Glenn Dranoff, Peter S Hammerman, Kwok-Kin Wong
STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppressor genes, such as STK11/LKB1, exerts similar effects. In this study, we investigated the consequences of STK11/LKB1 loss on the immune microenvironment in a mouse model of KRAS-driven NSCLC. Genetic ablation of STK11/LKB1 resulted in accumulation of neutrophils with T-cell-suppressive effects, along with a corresponding increase in the expression of T-cell exhaustion markers and tumor-promoting cytokines...
March 1, 2016: Cancer Research
Keith W Michael, Thomas M Neustein, John M Rhee
BACKGROUND CONTEXT: Open-door laminoplasty is a useful operation in the surgical management of cervical myelopathy with favorable outcomes and relatively low complications. One potential undesirable outcome is a decrease in cervical lordosis postoperatively. It is unknown whether the most proximal level undergoing laminoplasty affects the magnitude of loss of lordosis. PURPOSE: This study aimed to compare the loss of cervical lordosis postoperatively in patients for whom the most proximal level undergoing laminoplasty is C3 versus C4...
June 2016: Spine Journal: Official Journal of the North American Spine Society
Robert M Porsch, Christel M Middeldorp, Stacey S Cherny, Eva Krapohl, Catharina E M van Beijsterveldt, Anu Loukola, Tellervo Korhonen, Lea Pulkkinen, Robin Corley, Soo Rhee, Jaakko Kaprio, Richard R Rose, John K Hewitt, Pak Sham, Robert Plomin, Dorret I Boomsma, Meike Bartels
The genetic and environmental contributions to the variation and longitudinal stability in childhood aggressive behavior were assessed in two large twin cohorts, the Netherlands Twin Register (NTR), and the Twins Early Development Study (TEDS; United Kingdom). In NTR, maternal ratings on aggression from the Child Behavior Checklist (CBCL) were available for 10,765 twin pairs at age 7, for 8,557 twin pairs at age 9/10, and for 7,176 twin pairs at age 12. In TEDS, parental ratings of conduct disorder from the Strength and Difficulty Questionnaire (SDQ) were available for 6,897 twin pairs at age 7, for 3,028 twin pairs at age 9 and for 5,716 twin pairs at age 12...
July 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Vikram Saini, Bridgette M Cumming, Loni Guidry, Dirk A Lamprecht, John H Adamson, Vineel P Reddy, Krishna C Chinta, James H Mazorodze, Joel N Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J C Steyn
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT to Mtb redox homeostasis and virulence remains unknown. We report that Mtb WhiB3, a 4Fe-4S redox sensor protein, regulates EGT production and maintains bioenergetic homeostasis. We show that central carbon metabolism and lipid precursors regulate EGT production and that EGT modulates drug sensitivity...
January 26, 2016: Cell Reports
Virginia Chow, Young Sik Kim, Mun Su Rhee, Neha Sawhney, Franz J St John, Guang Nong, John D Rice, James F Preston
Paenibacillus sp. strain JDR-2 (Paenibacillus JDR-2) secretes a multimodular cell-associated glycoside hydrolase family 10 (GH10) endoxylanase (XynA10A1) that catalyzes the depolymerization of methylglucuronoxylan (MeGXn) and rapidly assimilates the products of depolymerization. Efficient utilization of MeGXn has been postulated to result from the coupling of the processes of exocellular depolymerization and assimilation of oligosaccharide products, followed by intracellular metabolism. Growth and substrate utilization patterns with barley glucan and laminarin similar to those observed with MeGXn as a substrate suggest similar processes for 1,3-1,4-β-glucan and 1,3-β-glucan depolymerization and product assimilation...
March 2016: Applied and Environmental Microbiology
Connie M Rhee, Vanessa A Ravel, Juan Carlos Ayus, John J Sim, Elani Streja, Rajnish Mehrotra, Alpesh N Amin, Danh V Nguyen, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND: A consistent association between low serum sodium measured at a single-point-in-time (baseline sodium) and higher mortality has been observed in hemodialysis patients. We hypothesized that both low and high time-varying sodium levels (sodium levels updated at quarterly intervals as a proxy of short-term exposure) are independently associated with higher death risk in hemodialysis patients. METHODS: We examined the association of baseline and time-varying pre-dialysis serum sodium levels with all-cause mortality among adult incident hemodialysis patients receiving care from a large national dialysis organization during January 2007-December 2011...
June 2016: Nephrology, Dialysis, Transplantation
Lac Tran, Michael Batech, Connie M Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Steven J Jacobsen, John J Sim
BACKGROUND: We hypothesized that phosphorus has an effect on anemia in both normal kidney function and early chronic kidney disease (CKD). We sought to determine whether higher phosphorus levels are associated with anemia in a large diverse population without CKD and early CKD. METHODS: This study is a historical population-based study within the Kaiser Permanente Southern California health system (1 January 1998 to 31 December 2013) among individuals aged 18 years and older with estimated glomerular filtration rate >30 mL/min/1...
April 2016: Nephrology, Dialysis, Transplantation
Jung-Hoon Kim, John M Rhee, Yoshio Enyo, William C Hutton, Sung-Soo Kim
BACKGROUND: To date, there has been no adequate biomechanical model that would allow a quantitative comparison in terms of stability/stiffness between a corpectomy with the posterior column preserved and a total spondylectomy with the posterior column sacrificed. The objective of this study was to perform a biomechanical comparison of 360° stabilizations for corpectomy and total spondylectomy, using the human thoracolumbar spine. METHODS: Five human cadaveric thoracolumbar spines (T8-L2) were tested according to the following loading protocol: axial compression, flexion, extension, lateral bending to the right and left, and axial rotation to the right and left...
2015: Journal of Orthopaedic Surgery and Research
Rajiv Saran, Yi Li, Bruce Robinson, John Ayanian, Rajesh Balkrishnan, Jennifer Bragg-Gresham, Joline T L Chen, Elizabeth Cope, Debbie Gipson, Kevin He, William Herman, Michael Heung, Richard A Hirth, Steven S Jacobsen, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Alan B Leichtman, Yee Lu, Miklos Z Molnar, Hal Morgenstern, Brahmajee Nallamothu, Ann M O'Hare, Ronald Pisoni, Brett Plattner, Friedrich K Port, Panduranga Rao, Connie M Rhee, Douglas E Schaubel, David T Selewski, Vahakn Shahinian, John J Sim, Peter Song, Elani Streja, Manjula Kurella Tamura, Francesca Tentori, Paul W Eggers, Lawrence Y C Agodoa, Kevin C Abbott
No abstract text is available yet for this article.
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Evan O Baird, John M Rhee, Shah-Nawaz M Dodwad, Alpesh A Patel
No abstract text is available yet for this article.
July 2015: Journal of Spinal Disorders & Techniques
Michael B Gottschalk, Ajay Premkumar, Kyle Sweeney, Scott D Boden, John Heller, S Tim Yoon, John M Rhee, Steven K Leckie, Brett Braly, Andrew K Simpson, Eric Lenehan
STUDY DESIGN: Independent retrospective review of prospectively collected data, comparative cohort study. OBJECTIVE: The objective of this study was to compare the clinical, radiographical, and cost/value of the addition of an interbody arthrodesis (IBA) to a posterolateral arthrodesis (PLA) in the surgical treatment of L4-L5 degenerative spondylolisthesis (DS). The authors hypothesized that the addition of IBA to PLA would produce added value while incurring minimal additional costs...
June 15, 2015: Spine
Paungpaga Lertdumrongluk, Elani Streja, Connie M Rhee, John J Sim, Daniel Gillen, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND AND OBJECTIVES: Pulse pressure has been shown as a risk factor for mortality in patients on maintenance hemodialysis (MHD). However, the effect of change in pulse pressure during hemodialysis on survival in a large cohort of patients on MHD has not been sufficiently investigated. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined the association between time-varying Δ pulse pressure (postdialysis minus predialysis pulse pressure) and mortality in a cohort of 98,577 patients on MHD (July 2001-June 2006) using Cox proportional hazard models with restricted cubic splines...
July 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
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