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John M. Rhee

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https://www.readbyqxmd.com/read/28201764/seasonal-variations-in-transition-mortality-and-kidney-transplantation-among-patients-with-end-stage-renal-disease-in-the-usa
#1
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Elani Streja, Connie M Rhee, Uttam G Reddy, Melissa Soohoo, Yaping Wang, Vanessa Ravel, Amy S You, Jennie Jing, John J Sim, Danh V Nguyen, Daniel L Gillen, Rajiv Saran, Bruce Robinson, Csaba P Kovesdy
No abstract text is available yet for this article.
February 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28201698/transition-of-care-from-pre-dialysis-prelude-to-renal-replacement-therapy-the-blueprints-of-emerging-research-in-advanced-chronic-kidney-disease
#2
Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Elani Streja, Connie M Rhee, Melissa Soohoo, Joline L T Chen, Miklos Z Molnar, Yoshitsugu Obi, Daniel Gillen, Danh V Nguyen, Keith C Norris, John J Sim, Steve S Jacobsen
No abstract text is available yet for this article.
February 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28139171/correlation-between-subjective-nasal-patency-and-intranasal-airflow-distribution
#3
Kevin P Casey, Azadeh A T Borojeni, Lisa J Koenig, John S Rhee, Guilherme J M Garcia
Objectives (1) Analyze the relationship between intranasal airflow distribution and subjective nasal patency in healthy and nasal airway obstruction (NAO) cohorts using computational fluid dynamics (CFD). (2) Determine whether intranasal airflow distribution is an important objective measure of airflow sensation that should be considered in future NAO virtual surgery planning. Study Design Cross-sectional. Setting Academic tertiary medical center and academic dental clinic. Subjects and Methods Three-dimensional models of nasal anatomy were created based on computed tomography scans of 15 patients with NAO and 15 healthy subjects and used to run CFD simulations of nasal airflow and mucosal cooling...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28092341/unilateral-spinous-process-non-covering-hook-type-patient-specific-drill-template-for-thoracic-pedicle-screw-fixation-a-pilot-clinical-trial-and-template-classification
#4
Sang Bum Kim, Yougun Won, Hyun Jin Yoo, Lee Jae Sin, John M Rhee, Sang Wook Lee, Gi-Soo Lee
STUDY DESIGN: Prospective Clinical Pilot tudy OBJECTIVE.: To confirm the accuracy of thoracic pedicle screw placement by using the unilateral spinous non-covering hook type patient-specific drill template (PSDT) made through rapid prototyping (RP) and to analyze previously reported PSDT designs and their characteristics. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is the most common form of the posterior instrumentation of the thoracic and lumbar spine. Various techniques have been introduced to improve pedicle screw placement...
January 13, 2017: Spine
https://www.readbyqxmd.com/read/28089607/estimates-of-nasal-airflow-at-the-nasal-cycle-mid-point-improve-the-correlation-between-objective-and-subjective-measures-of-nasal-patency
#5
Courtney Gaberino, John S Rhee, Guilherme J M Garcia
INTRODUCTION: The nasal cycle represents a significant challenge when comparing pre- and post-surgery objective measures of nasal airflow. METHODS: Computational fluid dynamics (CFD) simulations of nasal airflow were conducted in 12 nasal airway obstruction patients showing significant nasal cycling between pre- and post-surgery computed tomography scans. To correct for the nasal cycle, mid-cycle models were created virtually. Subjective scores of nasal patency were obtained via the Nasal Obstruction Symptom Evaluation (NOSE) and unilateral visual analog scale (VAS)...
April 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28018601/the-society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-hematologic-malignancies-multiple-myeloma-lymphoma-and-acute-leukemia
#6
Michael Boyiadzis, Michael R Bishop, Rafat Abonour, Kenneth C Anderson, Stephen M Ansell, David Avigan, Lisa Barbarotta, Austin John Barrett, Koen Van Besien, P Leif Bergsagel, Ivan Borrello, Joshua Brody, Jill Brufsky, Mitchell Cairo, Ajai Chari, Adam Cohen, Jorge Cortes, Stephen J Forman, Jonathan W Friedberg, Ephraim J Fuchs, Steven D Gore, Sundar Jagannath, Brad S Kahl, Justin Kline, James N Kochenderfer, Larry W Kwak, Ronald Levy, Marcos de Lima, Mark R Litzow, Anuj Mahindra, Jeffrey Miller, Nikhil C Munshi, Robert Z Orlowski, John M Pagel, David L Porter, Stephen J Russell, Karl Schwartz, Margaret A Shipp, David Siegel, Richard M Stone, Martin S Tallman, John M Timmerman, Frits Van Rhee, Edmund K Waller, Ann Welsh, Michael Werner, Peter H Wiernik, Madhav V Dhodapkar
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27922577/is-it-in-or-out-the-optimal-fluoroscopic-views-for-intraoperative-determination-of-proper-lateral-mass-screw-placement
#7
Sang Bum Kim, John M Rhee, Byung Hak Oh, You Gun Won, Yousun Jung, Kun Young Park, William C Hutton, Chulmin Kim
STUDY DESIGN: Cadaveric OBJECTIVE.: Determine optimal fluoroscopic views for detecting cervical lateral mass screw (LMS) violations SUMMARY OF BACKGROUND DATA.: Single plane intraoperative xrays are commonly used but frequently inadequate due to its complex trajectory. Fluoroscopy can be taken in multiple planes, but the ideal fluoroscopic view to assess malposition is not known: depending on the view, any given screw may look "in" or "out". METHODS: C3-6 LMS were inserted in 3 cadavers...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27807125/a-genetic-epidemiological-mega-analysis-of-smoking-initiation-in-adolescents
#8
Hermine H Maes, Elizabeth Prom-Wormley, Lindon J Eaves, Soo Hyun Rhee, John K Hewitt, Susan Young, Robin Corley, Matt McGue, William G Iacono, Lisa Legrand, Diana R Samek, E Lenn Murrelle, Judy L Silberg, Donna R Miles, Richard M Schieken, Gaston P Beunen, Martine Thomis, Richard J Rose, Danielle M Dick, Dorret I Boomsma, Meike Bartels, Jacqueline M Vink, Paul Lichtenstein, Victoria White, Jaakko Kaprio, Michael C Neale
INTRODUCTION: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation (SI) across adolescence. METHODS: Mega-analysis of pooled genetically informative data on SI was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N = 19 313 pairs) between ages 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the United States, Europe, and Australia...
November 2, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27525807/creation-of-an-idealized-nasopharynx-geometry-for-accurate-computational-fluid-dynamics-simulations-of-nasal-airflow-in-patient-specific-models-lacking-the-nasopharynx-anatomy
#9
Azadeh A T Borojeni, Dennis O Frank-Ito, Julia S Kimbell, John S Rhee, Guilherme J M Garcia
Virtual surgery planning based on computational fluid dynamics (CFD) simulations has the potential to improve surgical outcomes for nasal airway obstruction patients, but the benefits of virtual surgery planning must outweigh the risks of radiation exposure. Cone beam computed tomography (CT) scans represent an attractive imaging modality for virtual surgery planning due to lower costs and lower radiation exposures compared with conventional CT scans. However, to minimize the radiation exposure, the cone beam CT sinusitis protocol sometimes images only the nasal cavity, excluding the nasopharynx...
August 15, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27358272/serum-sodium-and-mortality-in-a-national-peritoneal-dialysis-cohort
#10
Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, John J Sim, Kevin Harley, Juan Carlos Ayus, Alpesh N Amin, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Sodium disarrays are common in peritoneal dialysis (PD) patients, and may be associated with adverse outcomes in this population. However, few studies of limited sample size have examined the association of serum sodium with mortality in PD patients, with inconsistent results. We hypothesized that both hypo- and hypernatremia are associated with higher death risk in a nationally representative cohort of US PD patients. METHODS: We sought to examine the association of serum sodium over time and mortality among 4687 adult incident PD patients from a large US dialysis organization who underwent one or more serum sodium measurements within the first 3 months of dialysis over January 2007 to December 2011...
June 29, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27352376/-inline-axial-reconstructed-ct-scans-provide-a-significantly-larger-assessment-of-c2-pedicle-diameter-for-screw-placement-compared-with-standard-axial-scans-implications-for-surgical-planning
#11
David E Vizurraga, John M Rhee, Timothy C Borden, Ashton S Mansour
STUDY DESIGN: Radiologic analysis. OBJECTIVE: The objective was to compare C2 pedicle diameter and screw feasibility on reconstructed axial computed tomography (CT) cuts created "Inline" (IL) with the intended pedicle screw tract versus unaltered "Standard" (STD) axial cuts. BACKGROUND DATA: Axial CT cuts through the C2 pedicle are commonly evaluated when planning pedicle screw fixation as medial aberrancies of the vertebral artery can significantly narrow pedicle diameter...
June 27, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27165673/impact-of-middle-versus-inferior-total-turbinectomy-on-nasal-aerodynamics
#12
Anupriya Dayal, John S Rhee, Guilherme J M Garcia
OBJECTIVES: This computational study aims to (1) use virtual surgery to theoretically investigate the maximum possible change in nasal aerodynamics after turbinate surgery, (2) quantify the relative contributions of the middle and inferior turbinates to nasal resistance and air conditioning, and (3) quantify to what extent total turbinectomy impairs the nasal air-conditioning capacity. STUDY DESIGN: Virtual surgery and computational fluid dynamics. SETTING: Academic tertiary medical center...
September 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27083059/the-relationship-between-nasal-resistance-to-airflow-and-the-airspace-minimal-cross-sectional-area
#13
Guilherme J M Garcia, Benjamin M Hariri, Ruchin G Patel, John S Rhee
The relationship between nasal resistance (R) and airspace minimal cross-sectional area (mCSA) remains unclear. After the introduction of acoustic rhinometry, many otolaryngologists believed that mCSA measurements would correlate with subjective perception of nasal airway obstruction (NAO), and thus could provide an objective measure of nasal patency to guide therapy. However, multiple studies reported a low correlation between mCSA and subjective nasal patency, and between mCSA and R. This apparent lack of correlation between nasal form and function has been a long-standing enigma in the field of rhinology...
June 14, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/26975457/surgical-management-of-gorham-disease-involving-the-upper-cervical-spine-with-occipito-cervical-thoracic-fusion-a-case-report
#14
Adam Schell, John M Rhee, Abigail Allen, Lindsay Andras, Feifei Zhou
BACKGROUND CONTEXT: Gorham disease is a rare osteolytic condition, with only 17 reported cases primarily affecting the cervical spine. PURPOSE: We report the case of a 31-year-old woman with severe kyphotic instability and myelopathy of the upper cervical spine secondary to massive osteolysis of the posterior elements. The surgical management, clinical outcome, and review of the relevant literature are discussed. STUDY DESIGN: This is a case report and a literature review...
July 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26925525/us-renal-data-system-2015-annual-data-report-epidemiology-of-kidney-disease-in-the-united-states
#15
REVIEW
Rajiv Saran, Yi Li, Bruce Robinson, Kevin C Abbott, Lawrence Y C Agodoa, John Ayanian, Jennifer Bragg-Gresham, Rajesh Balkrishnan, Joline L T Chen, Elizabeth Cope, Paul W Eggers, Daniel Gillen, Debbie Gipson, Susan M Hailpern, Yoshio N Hall, Kevin He, William Herman, Michael Heung, Richard A Hirth, David Hutton, Steven J Jacobsen, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Yee Lu, Miklos Z Molnar, Hal Morgenstern, Brahmajee Nallamothu, Danh V Nguyen, Ann M O'Hare, Brett Plattner, Ronald Pisoni, Friedrich K Port, Panduranga Rao, Connie M Rhee, Ankit Sakhuja, Douglas E Schaubel, David T Selewski, Vahakn Shahinian, John J Sim, Peter Song, Elani Streja, Manjula Kurella Tamura, Francesca Tentori, Sarah White, Kenneth Woodside, Richard A Hirth
No abstract text is available yet for this article.
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26833127/stk11-lkb1-deficiency-promotes-neutrophil-recruitment-and-proinflammatory-cytokine-production-to-suppress-t-cell-activity-in-the-lung-tumor-microenvironment
#16
Shohei Koyama, Esra A Akbay, Yvonne Y Li, Amir R Aref, Ferdinandos Skoulidis, Grit S Herter-Sprie, Kevin A Buczkowski, Yan Liu, Mark M Awad, Warren L Denning, Lixia Diao, Jing Wang, Edwin R Parra-Cuentas, Ignacio I Wistuba, Margaret Soucheray, Tran Thai, Hajime Asahina, Shunsuke Kitajima, Abigail Altabef, Jillian D Cavanaugh, Kevin Rhee, Peng Gao, Haikuo Zhang, Peter E Fecci, Takeshi Shimamura, Matthew D Hellmann, John V Heymach, F Stephen Hodi, Gordon J Freeman, David A Barbie, Glenn Dranoff, Peter S Hammerman, Kwok-Kin Wong
STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppressor genes, such as STK11/LKB1, exerts similar effects. In this study, we investigated the consequences of STK11/LKB1 loss on the immune microenvironment in a mouse model of KRAS-driven NSCLC. Genetic ablation of STK11/LKB1 resulted in accumulation of neutrophils with T-cell-suppressive effects, along with a corresponding increase in the expression of T-cell exhaustion markers and tumor-promoting cytokines...
March 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26828011/where-should-a-laminoplasty-start-the-effect-of-the-proximal-level-on-post-laminoplasty-loss-of-lordosis
#17
Keith W Michael, Thomas M Neustein, John M Rhee
BACKGROUND CONTEXT: Open-door laminoplasty is a useful operation in the surgical management of cervical myelopathy with favorable outcomes and relatively low complications. One potential undesirable outcome is a decrease in cervical lordosis postoperatively. It is unknown whether the most proximal level undergoing laminoplasty affects the magnitude of loss of lordosis. PURPOSE: This study aimed to compare the loss of cervical lordosis postoperatively in patients for whom the most proximal level undergoing laminoplasty is C3 versus C4...
June 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26786601/longitudinal-heritability-of-childhood-aggression
#18
Robert M Porsch, Christel M Middeldorp, Stacey S Cherny, Eva Krapohl, Catharina E M van Beijsterveldt, Anu Loukola, Tellervo Korhonen, Lea Pulkkinen, Robin Corley, Soo Rhee, Jaakko Kaprio, Richard R Rose, John K Hewitt, Pak Sham, Robert Plomin, Dorret I Boomsma, Meike Bartels
The genetic and environmental contributions to the variation and longitudinal stability in childhood aggressive behavior were assessed in two large twin cohorts, the Netherlands Twin Register (NTR), and the Twins Early Development Study (TEDS; United Kingdom). In NTR, maternal ratings on aggression from the Child Behavior Checklist (CBCL) were available for 10,765 twin pairs at age 7, for 8,557 twin pairs at age 9/10, and for 7,176 twin pairs at age 12. In TEDS, parental ratings of conduct disorder from the Strength and Difficulty Questionnaire (SDQ) were available for 6,897 twin pairs at age 7, for 3,028 twin pairs at age 9 and for 5,716 twin pairs at age 12...
July 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26774486/ergothioneine-maintains-redox-and-bioenergetic-homeostasis-essential-for-drug-susceptibility-and-virulence-of-mycobacterium-tuberculosis
#19
Vikram Saini, Bridgette M Cumming, Loni Guidry, Dirk A Lamprecht, John H Adamson, Vineel P Reddy, Krishna C Chinta, James H Mazorodze, Joel N Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J C Steyn
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT to Mtb redox homeostasis and virulence remains unknown. We report that Mtb WhiB3, a 4Fe-4S redox sensor protein, regulates EGT production and maintains bioenergetic homeostasis. We show that central carbon metabolism and lipid precursors regulate EGT production and that EGT modulates drug sensitivity...
January 26, 2016: Cell Reports
https://www.readbyqxmd.com/read/26746717/a-1-3-1-4-%C3%AE-glucan-utilization-regulon-in-paenibacillus-sp-strain-jdr-2
#20
Virginia Chow, Young Sik Kim, Mun Su Rhee, Neha Sawhney, Franz J St John, Guang Nong, John D Rice, James F Preston
Paenibacillus sp. strain JDR-2 (Paenibacillus JDR-2) secretes a multimodular cell-associated glycoside hydrolase family 10 (GH10) endoxylanase (XynA10A1) that catalyzes the depolymerization of methylglucuronoxylan (MeGXn) and rapidly assimilates the products of depolymerization. Efficient utilization of MeGXn has been postulated to result from the coupling of the processes of exocellular depolymerization and assimilation of oligosaccharide products, followed by intracellular metabolism. Growth and substrate utilization patterns with barley glucan and laminarin similar to those observed with MeGXn as a substrate suggest similar processes for 1,3-1,4-β-glucan and 1,3-β-glucan depolymerization and product assimilation...
January 8, 2016: Applied and Environmental Microbiology
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