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https://www.readbyqxmd.com/read/29708891/frequency-and-acceptability-of-adverse-events-after-anterior-cervical-discectomy-and-fusion-a-survey-study-from-the-cervical-spine-research-society
#1
Jefferson R Wilson, Kris Radcliff, Gregory Schroeder, Madison Booth, Christopher Lucasti, Michael Fehlings, Nassr Ahmad, Alexander Vaccaro, Paul Arnold, Daniel Sciubba, Alex Ching, Justin Smith, Christopher Shaffrey, Kern Singh, Bruce Darden, Scott Daffner, Ivan Cheng, Zoher Ghogawala, Steven Ludwig, Jacob Buchowski, Darrel Brodke, Jeffrey Wang, Ronald A Lehman, Alan Hilibrand, Tim Yoon, Jonathan Grauer, Andrew Dailey, Michael Steinmetz, James S Harrop
PURPOSE: Anterior cervical discectomy and fusion has a low but well-established profile of adverse events. The goal of this study was to gauge surgeon opinion regarding the frequency and acceptability of these events. METHODS: A 2-page survey was distributed to attendees at the 2015 Cervical Spine Research Society (CSRS) meeting. Respondents were asked to categorize 18 anterior cervical discectomy and fusion-related adverse events as either: "common and acceptable," "uncommon and acceptable," "uncommon and sometimes acceptable," or "uncommon and unacceptable...
April 27, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29708570/longer-operative-time-is-associated-with-increased-adverse-events-after-anterior-cervical-diskectomy-and-fusion-15-minute-intervals-matter
#2
Nathaniel T Ondeck, Daniel D Bohl, Ryan P McLynn, Jonathan J Cui, Patawut Bovonratwet, Kern Singh, Jonathan N Grauer
Little is known about the impact of operative time, as an independent and interval variable, on general health perioperative outcomes following anterior cervical diskectomy and fusion. Therefore, patients undergoing a 1-level anterior cervical diskectomy and fusion were identified in the American College of Surgeons National Surgical Quality Improvement Program. Operative time (as an interval variable) was tested for association with perioperative outcomes using a multivariate regression that was adjusted for differences in baseline characteristics...
April 27, 2018: Orthopedics
https://www.readbyqxmd.com/read/29707876/maintenance-dose-conversion-between-oral-risperidone-and-paliperidone-palmitate-1-month-practical-guidance-based-on-pharmacokinetic-simulations
#3
Alberto Russu, Jennifer Kern Sliwa, Paulien Ravenstijn, Arun Singh, Maju Mathews, Edward Kim, Srihari Gopal
AIM: We assessed the dosage strengths of paliperidone palmitate 1-month (PP1M) long-acting injectable resulting in similar steady-state (SS) exposures to the dosage strengths of oral risperidone using pharmacokinetic (PK) simulations. METHODS: Population PK simulations of SS PK were performed using the PK models of oral risperidone and PP1M. The concentrations of active moiety (risperidone + paliperidone) from risperidone were compared to paliperidone concentrations resulting from PP1M administration...
April 30, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29652236/validity-of-promis-in-minimally-invasive-transforaminal-lumbar-interbody-fusion-a-preliminary-evaluation
#4
Brittany E Haws, Benjamin Khechen, Jordan A Guntin, Kaitlyn L Cardinal, Daniel D Bohl, Kern Singh
OBJECTIVE Patient-reported outcomes are commonly used to evaluate treatment efficacy. Inefficiencies in standard measurement tools often prove to be a barrier to data collection. The Patient-Reported Outcomes Measurement Information System (PROMIS) was developed to overcome these limitations. This tool implements computer-adaptive testing, which enables the assessment of physical function in fewer questions than those required for "static" metrics. In spine surgery patients, moderate to strong correlations with Oswestry Disability Index (ODI) and the 36-Item Short Form Survey (SF-36) scores have been reported for PROMIS...
April 13, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29608450/does-day-of-surgery-affect-hospital-length-of-stay-and-charges-following-minimally-invasive-transforaminal-lumbar-interbody-fusion
#5
Fady Y Hijji, Ankur S Narain, Brittany E Haws, Benjamin Khechen, Krishna T Kudaravalli, Kelly H Yom, Kern Singh
STUDY DESIGN: Retrospective Cohort. OBJECTIVE: To determine if an association exists between surgery day and length of stay or hospital costs after minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARYOF BACKGROUND DATA: Length of inpatient stay after orthopedic procedures has been identified as a primary cost driver, and previous research has focused on determining risk factors for prolonged length of stay. In the arthroplasty literature, surgery performed later in the week has been identified as a predictor of increased length of stay...
March 31, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29605236/youtube-as-a-source-of-information-for-obstructive-sleep-apnea
#6
Sameer K Singh, Stanley Liu, Robson Capasso, Robert C Kern, Christopher J Gouveia
PURPOSE: Assess the quality of information on obstructive sleep apnea (OSA) presented on YouTube for patients. MATERIALS AND METHODS: "Obstructive sleep apnea" was entered into the YouTube search. Two independent reviewers categorized and analyzed videos utilizing a customized scoring-system along with search position, likes, and views. RESULTS: Forty-eight videos were analyzed. Most were educational (52.1%). Educational and news videos had significantly higher scores, but had no significant differences in search position, likes/day, or views/day...
March 19, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29494348/methodological-challenges-in-indirect-treatment-comparisons-spotlight-on-a-recent-comparison-of-long-acting-injectable-aripiprazole-versus-paliperidone-palmitate-in-the-treatment-of-schizophrenia
#7
Arun Singh, Srihari Gopal, Edward Kim, Maju Mathews, Jennifer Kern-Sliwa, Ibrahim Turkoz, Annette Wooller, Jesse Berlin
In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative advantages for aripiprazole once monthly over paliperidone palmitate once monthly in the short-term treatment of schizophrenia. However, the validity of the study is compromised as an indirect treatment comparison using extant data may violate important assumptions...
March 1, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29465423/patient-perceptions-of-minimally-invasive-versus-open-spine-surgery
#8
Ankur S Narain, Fady Y Hijji, Gabriel Duhancioglu, Brittany E Haws, Benjamin Khechen, Blaine T Manning, Matthew W Colman, Kern Singh
STUDY DESIGN: Prospective questionnaire. OBJECTIVE: To describe patient perceptions of minimally invasive spine (MIS) versus open surgery, and to determine which factors are most heavily considered by the patient when choosing between approaches. SUMMARY OF BACKGROUND DATA: MIS surgery has increased in popularity due to proposed advantages in the perioperative and immediate postoperative periods. However, patient preferences and understanding with regard to the differences between MIS and open surgery have not been elucidated...
April 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29462060/iliac-crest-bone-graft-for-minimally-invasive-transforaminal-lumbar-interbody-fusion-a-prospective-analysis-of-inpatient-pain-narcotics-consumption-and-costs
#9
Brittany E Haws, Benjamin Khechen, Ankur S Narain, Fady Y Hijji, Kaitlyn L Cardinal, Jordan A Guntin, Kern Singh
STUDY DESIGN: Retrospective Analysis OBJECTIVE.: The aim of this study was to determine whether an association between increased acute pain, postoperative time, and direct hospital costs exists between the use of iliac crest bone grafting (ICBG) and bone morphogenic protein (BMP)-2 following a primary, single-level minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: ICBG has been associated with enhanced fusion rates...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29419716/authorship-trends-in-spine-publications-from-2000-to-2015
#10
Brittany E Haws, Benjamin Khechen, Kamran Movassaghi, Kelly H Yom, Jordan A Guntin, Kaitlyn L Cardinal, Noah B Shoshana, Kern Singh
STUDY DESIGN: Literature review. OBJECTIVE: To examine changes in authorship characteristics for Spine publications from the year 2000-2015. SUMMARY OF BACKGROUND DATA: Scientific publications are considered an indication of academic achievement for physicians. Recently, authorship trends have been investigated, however, limited information is available on this topic within spine-specific literature. METHODS: Original research articles published in Spine in the years 2000, 2005, 2010, and 2015 were evaluated...
February 6, 2018: Spine
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#11
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
April 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29215497/gender-differences-for-anterior-cervical-fusion-complications-and-length-of-stay
#12
Bryce A Basques, Fady Y Hijji, Benjamin Khechen, Brittany E Haws, Benjamin C Mayo, Dustin H Massel, Philip K Louie, Kaitlyn L Cardinal, Jordan A Guntin, Kern Singh
STUDY DESIGN: Retrospective cohort OBJECTIVE.: To assess differences in baseline characteristics between genders of patients undergoing anterior cervical discectomy and fusion (ACDF) and risk factors for adverse outcomes according to gender. SUMMARY OF BACKGROUND DATA: ACDF is a common treatment for cervical spine disease. To reduce the rate of complications, risk factors associated for adverse events have been identified. However, few studies have examined the risk for inferior outcomes or complications following ACDF by gender...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29192877/impact-of-body-mass-index-on-surgical-outcomes-narcotics-consumption-and-hospital-costs-following-anterior-cervical-discectomy-and-fusion
#13
Ankur S Narain, Fady Y Hijji, Brittany E Haws, Krishna T Kudaravalli, Kelly H Yom, Jonathan Markowitz, Kern Singh
OBJECTIVE Given the increasing prevalence of obesity, more patients with a high body mass index (BMI) will require surgical treatment for degenerative spinal disease. In previous investigations of lumbar spine pathology, obesity has been associated with worsened postoperative outcomes and increased costs. However, few studies have examined the association between BMI and postoperative outcomes following anterior cervical discectomy and fusion (ACDF) procedures. Thus, the purpose of this study was to compare surgical outcomes, postoperative narcotics consumption, complications, and hospital costs among BMI stratifications for patients who have undergone primary 1- to 2-level ACDF procedures...
February 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29049131/comparison-of-surgical-outcomes-narcotics-utilization-and-costs-after-an-anterior-cervical-discectomy-and-fusion-stand-alone-cage-versus-anterior-plating
#14
Ehsan Tabaraee, Junyoung Ahn, Daniel D Bohl, Michael J Collins, Dustin H Massel, Khaled Aboushaala, Kern Singh
STUDY DESIGN: Retrospective cohort analysis of a prospectively maintained registry. OBJECTIVE: To compare the surgical outcomes, narcotic utilization, and costs between a stand-alone (SA) cage and anterior plating (AP) with an interbody device for 1-level anterior cervical discectomy and fusion (ACDF). BACKGROUND DATA: ACDF with a SA cage has gained popularity as a potential alternative to anterior cervical plating. Few studies have compared the surgical outcomes, narcotic utilization, and costs of ACDF utilizing a SA cage versus AP with an interbody device...
November 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29027622/minimally-invasive-techniques-for-lumbar-decompressions-and-fusions
#15
REVIEW
Ankur S Narain, Fady Y Hijji, Jonathan S Markowitz, Krishna T Kudaravalli, Kelly H Yom, Kern Singh
PURPOSE OF REVIEW: The purpose of this study is to summarize the recent literature investigating the use of minimally invasive (MIS) techniques in the treatment of lumbar degenerative stenosis, spondylolisthesis, and scoliosis. RECENT FINDINGS: MIS lumbar decompression and fusion techniques for degenerative pathology are associated with reduced operative morbidity, shortened length of hospital stay, and reduced postoperative pain and narcotics utilization. Recent studies with long-term clinical follow-up have demonstrated equivalence in clinical outcomes between open and MIS surgical procedures...
December 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28953711/incidence-risk-factors-and-impact-of-clostridium-difficile-colitis-after-spine-surgery-an-analysis-of-a-national-database
#16
Patawut Bovonratwet, Daniel D Bohl, Glenn S Russo, Nathaniel T Ondeck, Kern Singh, Jonathan N Grauer
STUDY DESIGN: Retrospective study of prospectively collected data. OBJECTIVE: To utilize a large national database with post-hospitalization follow-up data (National Surgical Quality Improvement Program [NSQIP]) to determine the incidence, risk factors, timing, and clinical impact of C. difficile colitis in spine surgery patients. SUMMARY OF BACKGROUND DATA: Recent literature has suggested an increased incidence of C. difficile infections...
September 26, 2017: Spine
https://www.readbyqxmd.com/read/28945643/variation-in-spine-surgeon-selection-criteria-between-neurosurgery-and-orthopedic-surgery-patients
#17
Fady Y Hijji, Ankur S Narain, Brittany E Haws, Christopher D Witiw, Krishna T Kudaravalli, Kelly H Yom, Harel Deutsch, Kern Singh
STUDY DESIGN: A cross-sectional survey study. OBJECTIVE: The objective of this study is to determine if there are any differences in spine surgeon selection criteria between neurosurgery patients and orthopedic patients. BACKGROUND INFORMATION: The evolution of the health care delivery system has allowed for increased patient autonomy in provider selection. However, the process and criteria by which patients choose particular spine surgeons is not well understood...
March 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28857969/assessing-online-patient-education-readability-for-spine-surgery-procedures
#18
William W Long, Krishna D Modi, Brittany E Haws, Benjamin Khechen, Dustin H Massel, Benjamin C Mayo, Kern Singh
BACKGROUND CONTEXT: Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the American Medical Association and National Institute of Health, spine fusion articles should be written for a 4th-6th-grade reading level to increase patient comprehension, which may improve postoperative outcomes. PURPOSE: The purpose of this study is to determine the readability of online health care education information relating to anterior cervical discectomy and fusion (ACDF) and lumbar fusion procedures...
March 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28856354/severity-weighting-of-postoperative-adverse-events-in-orthopedic-surgery
#19
Daniel D Bohl, Junyoung Ahn, Adam M Lukasiewicz, Andre M Samuel, Matthew L Webb, Bryce A Basques, Nicholas S Golinvaux, Kern Singh, Jonathan N Grauer
Studies of adverse events (AEs) after orthopedic surgery commonly use composite AE outcomes. An example of such an outcome is any AE. These types of outcomes treat AEs with different clinical significance (eg, death, urinary tract infection) similarly. We conducted a study to address this shortcoming in research methodology by creating a single severity-weighted outcome that can be used to characterize the overall severity of a given patient's postoperative course. All orthopedic faculty members at 2 academic institutions were invited to complete a severity-weighting exercise in which AEs were assigned a percentage severity of death...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28808622/radiation-exposure-and-reduction-in-the-operating-room-perspectives-and-future-directions-in-spine-surgery
#20
REVIEW
Ankur S Narain, Fady Y Hijji, Kelly H Yom, Krishna T Kudaravalli, Brittany E Haws, Kern Singh
Intraoperative imaging is vital for accurate placement of instrumentation in spine surgery. However, the use of biplanar fluoroscopy and other intraoperative imaging modalities is associated with the risk of significant radiation exposure in the patient, surgeon, and surgical staff. Radiation exposure in the form of ionizing radiation can lead to cellular damage via the induction of DNA lesions and the production of reactive oxygen species. These effects often result in cell death or genomic instability, leading to various radiation-associated pathologies including an increased risk of malignancy...
July 18, 2017: World Journal of Orthopedics
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