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Pathologic myopia

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https://www.readbyqxmd.com/read/29453956/frequent-mutations-of-retnet-genes-in-eohm-further-confirmation-in-325-probands-and-comparison-with-late-onset-high-myopia-based-on-exome-sequencing
#1
Lin Zhou, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Qingjiong Zhang
In our previous study, potential pathological mutations of RetNet genes were detected in 23.8% (71/298) of probands with early-onset high myopia (eoHM), based on whole exome sequencing (WES). The current study aimed to confirm this finding in an additional 325 probands with eoHM and to clarify its specificity by comparison of 195 probands with late-onset high myopia (loHM). Variants in the 234 RetNet genes were selected from whole-exome sequencing data and were filtered using multistep bioinformatics analyses...
February 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29443802/full-thickness-macular-hole-with-macular-intrachoroidal-cavitation-in-a-patient-with-pathologic-myopia
#2
Nurgül Örnek, Kemal Örnek
PURPOSE: To describe a full-thickness macular hole (MH) opening to macular intrachoroidal cavitation in a patient with pathologic myopia. METHODS: Full ophthalmologic examination, fundus camera (Topcon TRC; Topcon Co, Tokyo, Japan), optical coherence tomography (RetinaScan Advanced RS-3000; NIDEK, Gamagori, Japan) imaging, and cataract surgery. RESULTS: A 61-year-old woman admitted with decreased vision in the left eye. Visual acuity was counting fingers from 30 cm...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29437569/myopia-its-historical-contexts
#3
REVIEW
Paulus T V M de Jong
Worldwide, and especially in Asia, myopia is a major vision-threatening disorder. From AD 1600 on, to prevent myopia, authors warned against near work without sufficient pauses. There was an abundance of theories about the causes of myopia, the most common one being the necessity of extra convergence on nearby work with thickened extraocular muscles and elevated intraocular pressure. Ocular tenotomies against myopia were in vogue for a while. Axial lengthening of the eye in myopia was mentioned around 1700, but it took 150 years to become accepted as the most prevalent sign of high myopia...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29397539/acquired-myopia-in-vogt-koyanagi-harada-disease
#4
Hiroyuki Takahashi, Hiroshi Takase, Yukiko Terada, Manabu Mochizuki, Kyoko Ohno-Matsui
PURPOSE: To analyze the change in refractive error and the axial length of chronic Vogt-Koyanagi-Harada (VKH) disease. METHODS: Medical records of 106 eyes of 54 adult VKH patients were analyzed. The refractive error and the axial length were compared between the baseline (defined as the time point at least 2 weeks after acute stage of VKH) and the final visit. The rate of the eyes with significant myopia progression [defined as refraction change toward myopia > 1 diopter (D)] was examined...
February 3, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29390361/comparison-of-the-efficacy-of-intravitreal-ranibizumab-for-choroidal-neovascularization-due-to-pathological-myopia-with-and-without-a-dome-shaped-macula
#5
Bincui Cai, Jin Yang, Shuang Li, Linni Wang, Lu Chen, Xiaorong Li, Zhiqing Li
Ranibizumab injection in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) with and without a dome-shaped macula (DSM).Prospective observational study.A total of 24 patients (24 eyes) with angiographic evidence of CNV secondary to PM were divided into 2 groups: eyes with a DSM and eyes without DSM. All patients received a baseline intravitreal ranibizumab injection. Additional injections were considered at each follow-up visit. Best-corrected visual acuity (BCVA) and optical coherence tomography were tested monthly through 12 months of follow-up...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29371011/progression-of-myopic-maculopathy-during-18-year-follow-up
#6
Yuxin Fang, Tae Yokoi, Natsuko Nagaoka, Kosei Shinohara, Yuka Onishi, Tomoka Ishida, Takeshi Yoshida, Xian Xu, Jost B Jonas, Kyoko Ohno-Matsui
PURPOSE: To examine the progression pattern of myopic maculopathy. DESIGN: Retrospective, observational case series. PARTICIPANTS: Highly myopic patients who had been followed up for 10 years or more. METHODS: Using fundus photographs, myopic features were differentiated according to Meta-analysis of Pathologic Myopia (META-PM) Study Group recommendations. MAIN OUTCOME MEASURES: Progression pattern of maculopathy...
January 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29369230/longitudinal-changes-in-disc-and-retinal-lesions-among-highly-myopic-adolescents-in-singapore-over-a-10-year-period
#7
Yee-Ling Wong, Yang Ding, Charumathi Sabanayagam, Chee-Wai Wong, Pavan Verkicharla, Kyoko Ohno-Matsui, Donald Tan, Anna Chwee-Hong Yeo, Quan V Hoang, Ecosse Lamoureux, Seang-Mei Saw
OBJECTIVES: To examine the progression pattern of disc and retinal lesions in highly myopic Chinese adolescents over a 10-year period in Singapore. METHODS: This longitudinal study included Chinese participants who showed high myopia (spherical equivalent [SE] worse than or equal to -5 diopters [D]), no history of refractive surgery, and available fundus photographs at both 2006 (baseline) and 2016 (10-year follow-up) visits. Forty-four adolescents (aged 12-16 years at baseline) who were re-examined later at follow-up were included...
January 22, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29288031/prevalence-and-characteristics-of-myopic-degeneration-in-an-adult-chinese-american-population-the-chinese-american-eye-study
#8
Farzana Choudhury, Stacy M Meuer, Ronald Klein, Dandan Wang, Mina Torres, Xuejuan Jiang, Roberta McKean-Cowdin, Rohit Varma
PURPOSE: To characterize and provide population-based prevalence estimates of myopic degeneration (MD) among Chinese Americans, the fastest growing minority population in the United States in the last decade. DESIGN: Population-based, cross-sectional study. METHODS: 1523 Chinese American adults with myopia, aged 50 years and older, residing in the City of Monterey Park, California, underwent an interview and comprehensive eye exam, including subjective and objective refraction, and stereoscopic fundus photography...
December 26, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260192/patchy-chorioretinal-atrophy-changes-at-the-posterior-pole-after-ranibizumab-for-myopic-choroidal-neovascularization
#9
Mariacristina Parravano, Fabio Scarinci, Marta Gilardi, Lea Querques, Monica Varano, Francesco Oddone, Francesco Bandello, Giuseppe Querques
Purpose: To investigate the potential role of ranibizumab treatment on the development or enlargement of chorioretinal atrophy (CRA) at the posterior pole in eyes with myopic choroidal neovascularization (mCNV). Methods: This observational case series included patients having high myopia spherical equivalent refractive error ≥ -6.00 diopters, axial length (AxL) ≥ 26.0 mm in both eyes, and mCNV treated with ranibizumab 0.5 mg in one eye, who were retrospectively enrolled...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29259393/the-retina-rpe-proteome-in-chick-myopia-and-hyperopia-models-commonalities-with-inherited-and-age-related-ocular-pathologies
#10
Nina Riddell, Pierre Faou, Melanie Murphy, Loretta Giummarra, Rachael A Downs, Harinda Rajapaksha, Sheila G Crewther
Purpose: Microarray and RNA sequencing studies in the chick model of early optically induced refractive error have implicated thousands of genes, many of which have also been linked to ocular pathologies in humans, including age-related macular degeneration (AMD), choroidal neovascularization, glaucoma, and cataract. These findings highlight the potential relevance of the chick model to understanding both refractive error development and the progression to secondary pathological complications...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29232337/retinal-telangiectasia-in-patients-with-pathologic-myopia-a-case-series
#11
Boya Lei, Ruiping Gu, Chen Jiang, Gezhi Xu
PURPOSE: To describe the characteristics of retinal telangiectasia in eyes with pathologic myopia. METHODS: The study included 10 patients (18 eyes) who were diagnosed with pathologic myopia combined with retinal telangiectasia. The patients visited our retinal clinic every 3 months. Nine eyes underwent vitrectomy for vision-threatening complications after diagnosis. All eyes underwent comprehensive ophthalmologic examinations including multimodal retinal imaging at presentation and at each follow-up...
December 8, 2017: Retina
https://www.readbyqxmd.com/read/29190623/axial-length-corneal-radius-of-curvature-ratio-assessment-of-posterior-sclera-reinforcement-for-pathologic-myopia
#12
Huiling Hu, Guangyu Zhao, Ruifeng Wu, Huahong Zhong, Min Fang, Hongwei Deng
PURPOSE: The aim of this study was to assess the axial length/corneal radius of curvature ratio changes after posterior scleral reinforcement (PSR) for pathologic myopia. PROCEDURES: This study enrolled 32 pathologically myopic eyes treated with PSR and 35 untreated pathologically myopic eyes. Axial length, refractive error, best corrected visual acuity, corneal radius of curvature, and the axial length/corneal radius of curvature ratio were evaluated during the 1-year follow-up...
November 30, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29183904/inverse-hypopyon-hyperoleon-at-the-posterior-segment-in-pathological-myopia
#13
Koushik Tripathy, Rohan Chawla
No abstract text is available yet for this article.
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29111299/diagnosis-and-treatment-guideline-for-myopic-choroidal-neovascularization-due-to-pathologic-myopia
#14
REVIEW
Kyoko Ohno-Matsui, Yasushi Ikuno, Timothy Y Y Lai, Chui Ming Gemmy Cheung
Pathologic myopia is a leading cause of visual impairment. Development of myopic choroidal neovascularization (CNV) is one of the most common complications that leads to central vision loss in patients with pathologic myopia. If left untreated, it can cause scarring with expanding macular atrophy leading to irreversible visual loss in a period as short as 5 years. Advancements in multimodal imaging technology have furthered our understanding of the condition; however, further studies are necessary to extend its utility in the diagnosis of myopic CNV...
October 27, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29096121/the-elastic-modulus-and-collagen-of-sclera-increase-during-the-early-growth-process
#15
Congcong Wang, Yongfang Xie, Guohui Wang
The aim of this study was to investigate the changes in the elastic modulus and collagen in scleral tissues of different ages. The eyeballs of 1-, 2- and 3-month-old New Zealand white rabbits were obtained to assess three regions of the sclera-anterior, equatorial and posterior. The three regions of the scleral tissues were then separately divided into four groups. The first group was made into scleral strips for elastic modulus measurement using an Instron 5544. The second group was HE stained for observation of the scleral structures...
October 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29057641/anti-vascular-endothelial-growth-factor-therapy-for-myopic-choroidal-neovascularization
#16
REVIEW
Danny S C Ng, Timothy Y Y Lai, Chui Ming Gemmy Cheung, Kyoko Ohno-Matsui
Myopic choroidal neovascularization (CNV) is one of the most vision-impairing complications in patients with pathologic myopia. It is also one of the most frequently encountered non.age-related macular degeneration causes of CNV and affects young patients in the working age group. Fluorescein angiography (FA) and spectral domain optical coherence tomography (OCT) are generally indicated to confirm the diagnosis of active myopic CNV before initiation of treatment. Without treatment, natural history studies have shown that the vision outcome can be very poor...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29054766/rethinking-genotype-phenotype-correlations-in-papillorenal-syndrome-a-case-report-on-an-unusual-congenital-camptodactyly-and-skeletal-deformity-with-a-heterogeneous-pax2-mutation-of-hexanucleotide-duplication
#17
Jiewei Liu, Ping Wang, Juan Huang, Zihua Yu
Papillorenal syndrome (PRS), an autosomal dominant inherited condition, is clinically featured by renal hypoplasia and optic nerve dysplasia. Based on current knowledge of genotype-phenotype correlations in PRS, mutations in the Paired box 2 (PAX2) gene have been recognized as a critical pathogenesis of typical renal and optic disease manifestations. However, little information is currently available on the skeletal abnormalities of PRS and the potential contribution of PAX2 mutations. Here, we present a case of a 10-year-old female PRS patient with the typical features of chronic renal failure and severe myopia, but was unexpectedly discovered camptodactyly of her left middle finger which affects the proximal interphalangeal joint...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29026284/anti-vascular-endothelial-growth-factor-therapy-for-the-treatment-of-myopic-choroidal-neovascularization
#18
REVIEW
Colin S Tan, SriniVas R Sadda
Myopic choroidal neovascularization (CNV) is a sight-threatening condition which occurs in eyes with myopia, particularly in those with pathologic myopia. It is the most common cause of CNV among patients younger than 50 years. Hemorrhage and exudation from the CNV lesion may eventually result in scarring or chorioretinal atrophy. While myopic CNV was previously treated with focal laser photocoagulation or photodynamic therapy (PDT), the current treatment of choice is anti-vascular endothelial growth factor (VEGF) agents...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29021916/vitrectomy-in-high-myopia-a-narrative-review
#19
REVIEW
Michele Coppola, Alessandro Rabiolo, Maria Vittoria Cicinelli, Giuseppe Querques, Francesco Bandello
Pathologic myopia is associated with degenerative changes of the globe, especially at the posterior pole. Eyes affected by pathologic myopia have higher odds to undergo posterior segment surgery and, in those eyes, vitreoretinal surgery is challenging. Many practical tips and tricks can make the surgical procedures simpler, significantly preventing sight-threatening intra- and post-operative complications. Moreover, novel surgical techniques and technological advancements (i.e. ad-hoc instrumentation, minimally invasive vitreoretinal surgery, filters, dye staining, intraoperative optical coherence tomography and 3-dimensional surgery) may play role in highly myopic eyes...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28951126/the-epidemics-of-myopia-aetiology-and-prevention
#20
REVIEW
Ian G Morgan, Amanda N French, Regan S Ashby, Xinxing Guo, Xiaohu Ding, Mingguang He, Kathryn A Rose
There is an epidemic of myopia in East and Southeast Asia, with the prevalence of myopia in young adults around 80-90%, and an accompanying high prevalence of high myopia in young adults (10-20%). This may foreshadow an increase in low vision and blindness due to pathological myopia. These two epidemics are linked, since the increasingly early onset of myopia, combined with high progression rates, naturally generates an epidemic of high myopia, with high prevalences of "acquired" high myopia appearing around the age of 11-13...
September 23, 2017: Progress in Retinal and Eye Research
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