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Pathologic myopia

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https://www.readbyqxmd.com/read/28432184/management-of-a-case-of-myopic-foveoschisis-with-phakic-intraocular-lens-piol-in-situ-intraoperative-challenges
#1
Atul Kumar, Aditi Mehta, Raghav Dinesh Ravani, Prateek Kakkar
We describe the case of a 30-year-old man with pathological myopia with a phakic intraocular lens (IOL) (Visian ICL V4c model; STAAR, Monrovia, California, USA) in situ having complaints of metamorphopsia in the left eye with documented myopic foveoschisis on swept-source optical coherence tomography (DRI OCT Triton; Topcon, Tokyo, Japan). The patient underwent pars plana vitrectomy with internal limiting membrane peeling. This report discusses the intraoperative challenges occurring as a result of increased optical aberrations in the presence of a phakic IOL...
April 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28393596/-intravitreal-ranibizumab-therapy-for-choroidal-neovascularization-secondary-to-pathological-myopia
#2
Regina Lukács, Gábor Sándor, Miklós Resch, Antal Szabó, György Barcsay, Mónika Ecsedy, Zsuzsanna Szepessy, Zoltán Zsolt Nagy, András Papp
INTRODUCTION: Pathological myopia is one of the leading causes of vision loss worldwide, especially among young people of working age. Choroidal neovascularization is one of the most important cause of visual impairment in pathological myopia. AIM: To evaluate the efficacy of intravitreal ranibizumab for the treatment of myopic choroidal neovascularization. METHOD: In this retrospective analysis 14 eyes of 14 patients (mean age: 61 ± 17 years) with myopic choroidal neovascularization were treated with intravitreal ranibizumab as needed...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28376046/autologous-internal-limiting-membrane-fragment-transplantation-for-rhegmatogenous-retinal-detachment-due-to-paravascular-or-juxtapapillary-retinal-breaks-over-patchy-chorioretinal-atrophy-in-pathologic-myopia
#3
Stanislao Rizzo, Ruggero Tartaro, Francesco Barca, Daniela Bacherini, Fabrizio Franco, Tomaso Caporossi
No abstract text is available yet for this article.
April 3, 2017: Retina
https://www.readbyqxmd.com/read/28366874/impaired-vitreous-composition-and-retinal-pigment-epithelium-function-in-the-foxg1-lrp2-myopic-mice
#4
Olivier Cases, Antoine Obry, Sirine Ben-Yacoub, Sébastien Augustin, Antoine Joseph, Géraldine Toutirais, Manuel Simonutti, Annabel Christ, Pascal Cosette, Renata Kozyraki
High myopia (HM) is one of the main causes of visual impairment and blindness all over the world and an unsolved medical problem. Persons with HM are predisposed to other eye pathologies such as retinal detachment, myopic retinopathy or glaucomatous optic neuropathy, complications that may at least partly result from the extensive liquefaction of the myopic vitreous gel. To identify the involvement of the liquid vitreous in the pathogenesis of HM we here analyzed the vitreous of the recently described highly myopic low density lipoprotein receptor-related protein 2 (Lrp2)-deficient eyes...
March 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28345561/insight-into-high-myopia-and-the-macula
#5
REVIEW
Atul Kumar, Rohan Chawla, Devesh Kumawat, Ganesh Pillay
The incidence of myopia is constantly on the rise. Patients of high myopia and pathological myopia are young and can lose vision due to a number of degenerative changes occurring at the macula. With the emergence of new technologies such as swept-source optical coherence tomography (OCT) and OCT angiography, our understanding of macular pathology in myopia has improved significantly. New conditions such as myopic traction maculopathy have been defined. Early, noninvasive detection of myopic choroidal neovascularization and its differentiation from lacquer cracks is possible with a greater degree of certainty...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28330571/use-of-3d-orbital-reconstruction-in-the-assessment-of-orbital-sexual-dimorphism-and-its-pathological-consequences
#6
N Graillon, C Boulze, P Adalian, A Loundou, L Guyot
INTRODUCTION: Surrounded by a variety of structures including the facial sinuses and the brain, the human orbit displays unique anatomical features. It is known that orbital volume correlates with age and sex. The aim of this study was to evaluate sexual dimorphism of orbital volume relative to the size of the skull, and to establish criteria for gender determination. METHODS: Orbital volume was measured from 3D models of the orbits. The volumes were expressed in relation to the centroid size of the skull, to ensure that any sexual dimorphism in orbital volume was not simply due to a difference in skull size...
February 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28282059/regarding-advances-of-optical-coherence-tomography-in-myopia-and-pathologic-myopia
#7
E H Wood, M A Powers, S R Sanislo, M W Gaynon
No abstract text is available yet for this article.
March 10, 2017: Eye
https://www.readbyqxmd.com/read/28225373/outer-retinal-tubulation-a-case-series
#8
Leticia A Rousso, Julie A Rodman, Brad Sutton, Diana L Shechtman
PURPOSE: The advent of spectral domain optical coherence tomography has led to superb imaging capabilities in addition to enhanced visualization of the retinal layers. Such advancements have led to the identification of a variety of new retinal conditions, including outer retinal tubulations (ORTs). ORTs are ovoid hyporeflective spaces located in the outer retina. The pathogenesis is unclear but seems to involve sublethal injury to the photoreceptors leading to a compensatory reorganization of the photoreceptor layer with the neighboring ellipsoid zone resulting in a hyperreflective border surrounding a central lumen...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28192841/6-year-results-of-cnv-secondary-to-pathological-myopia-treated-with-ranibizumab
#9
L Hefner, H Gerding
Background The current standard treatment of choroidal neovascularisation (CNV) secondary to pathological myopia (PM) is intravitreal injection of VEGF antagonists. We now present our 6-year results after treating patients with CNV secondary to PM with ranibizumab. Patients and Methods We retrospectively analysed 15 treatment-naive eyes of 13 patients (10 women, 3 men, mean age 59.2; standard deviation (SD) 11.1; range 41-78 years) with visual impairment related to CNV secondary to PM, who were treated with at least 1 injection of ranibizumab...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28166316/is-choroidal-or-scleral-thickness-related-to-myopic-macular-degeneration
#10
Chee Wai Wong, Val Phua, Shu Yen Lee, Tien Yin Wong, Chui Ming Gemmy Cheung
Purpose: The relative contribution of mechanical and vascular factors to the pathogenesis of myopic macular degeneration (MMD) is unclear. To address this gap, we examined the association of choroidal thickness (CT) and scleral thickness (ST) with MMD. Methods: Prospective, clinic-based case series of 62 eyes of 41 patients with high myopia (≤-6 diopters or axial length ≥26.5 mm). Swept-source optical coherence tomography (SSOCT) was performed to measure subfoveal CT and ST...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28164597/visual-system-homeobox-1-vsx1-gene-analysis-in-keratoconus-design-of-specific-primers-and-dna-amplification-protocols-for-accurate-molecular-characterization
#11
Jun B Ng, Rozaida Y Y Poh, Kenneth R Lee, Visvaraja Subrayan, Jenny P Deva, Amy Y L Lau, Jin A M A Tan
BACKGROUND: Keratoconus is an ocular degeneration characterized by the thinning of corneal stroma that may lead to varying degrees of myopia and visual impairment. Genetic factors have been reported in the pathology of keratoconus where Asians have a higher incidence, earlier onset, and undergo earlier corneal grafts compared to Caucasians. The visual system homeobox 1 (VSX1) gene forms part of a paired-like homeodomain transcription factor which is responsible for ocular development...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162199/-relation-between-ultrasonographic-characteristics-of-pathologic-myopia-posterior-staphyloma-and-retinoschisis
#12
Q Liu, S Y Li, X Chen
Objective: To study the ultrasonographic characteristics of pathologic myopia posterior staphyloma and the relation with retinoschisis. Methods: Retrospective case series study. Eighty-seven eyes of 66 pathologic myopia patients with posterior staphyloma were included. Staphyloma morphology and anteroposterior axis of the eyeball were observed by B-scan ultrasonography. Optical coherence tomography was used to explore the retinoschisis. Results: Arc-shaped (10.35%), cone-shaped (22.99%), wedge-shaped (33.33%) and rectangle-shaped (33...
January 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159853/vascular-flow-density-in-pathological-myopia-an-optical-coherence-tomography-angiography-study
#13
Jing Mo, Anli Duan, Szyyann Chan, Xuefei Wang, Wenbin Wei
OBJECTIVES: To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. DESIGN: A prospective comparative study was conducted from December 2015 to March 2016. SETTING: Participants were recruited in Beijing Tongren Hospital. PARTICIPANTS: A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28145971/subthreshold-laser-treatment-for-serous-retinal-detachment-in-dome-shaped-macula-associated-with-pathologic-myopia
#14
Maurizio Battaglia Parodi, Pierluigi Iacono, Francesco Bandello
PURPOSE: To evaluate the effects of the subthreshold laser treatment as a therapeutic option in the treatment of serous retinal detachment secondary to dome-shaped macula. METHODS: Prospective pilot study with 12-month follow-up. Each patient underwent a complete ophthalmologic examination, including best-corrected visual acuity, fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography. Eyes with persistent serous retinal detachment lasting for a minimum of 12 months and absence of best-corrected visual acuity improvement underwent subthreshold laser treatment in a single session...
January 31, 2017: Retina
https://www.readbyqxmd.com/read/28100480/detection-of-posterior-vortex-veins-in-eyes-with-pathologic-myopia-by-ultra-widefield-indocyanine-green-angiography
#15
Muka Moriyama, Kejia Cao, Satoko Ogata, Kyoko Ohno-Matsui
AIMS: To analyse the characteristics of posterior vortex veins detected in highly myopic eyes by wide-field indocyanine green angiography (ICGA). METHODS: One hundred and fifty-eight consecutive patients (302 eyes) with high myopia (myopic refractive error >8.0 dioptres (D) or axial length ≥26.5 mm) were studied. Wide-field ICGA was performed with the Spectralis HRA module. RESULTS: Posterior vortex veins were found in 80 eyes (26%)...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28009400/optical-coherence-tomography-imaging-in-the-management-of-the-argus-ii-retinal-prosthesis-system
#16
Francesco Parmeggiani, Katia De Nadai, Angela Piovan, Andrea Binotto, Sara Zamengo, Marzio Chizzolini
PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol...
January 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003976/application-of-optical-coherence-tomography-angiography-in-assessment-of-posterior-scleral-reinforcement-for-pathologic-myopia
#17
Jing Mo, An-Li Duan, Szy-Yann Chan, Xue-Fei Wang, Wen-Bin Wei
AIM: To investigate the effect of posterior scleral reinforcement (PSR) on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography (OCTA). METHODS: The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR (PSR group) for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary (RPC) flow density were measured by OCTA, and the measurements were compared between groups...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003787/pseudoduplication-of-the-optic-disc-in-moderate-myopia
#18
Zeynep Eylül Ercan, Aylin Karalezli, Gokcen Coban
We report a case of optic disc pseudoduplication without pathological myopia. A 79-year-old woman presented with gradually decreased vision. Fundus examination showed macular drusen in both eyes and subretinal haemorrhage in the left eye. Both optic discs appeared to be tilted and the left optic disc was seen to be inferiorly duplicated. Pseudodoubling of the optic discs can be caused by optic disc and peripapillary chorioretinal colobomas and pathological myopia. Considering that our patient did not have enough axial length to merit a diagnosis of pathological myopia and no pathological fundus lesions typical of elongated sclera, we suggest that acquired pseudoduplication is not a condition unique to pathological myopia, but can occur in all myopic patients...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27995965/identification-of-novel-x-linked-gain-of-function-rpgr-orf15-mutation-in-italian-family-with-retinitis-pigmentosa-and-pathologic-myopia
#19
Francesco Parmeggiani, Vanessa Barbaro, Katia De Nadai, Enrico Lavezzo, Stefano Toppo, Marzio Chizzolini, Giorgio Palù, Cristina Parolin, Enzo Di Iorio
The aim of this study was to describe a new pathogenic variant in the mutational hot spot exon ORF15 of retinitis pigmentosa GTPase regulator (RPGR) gene within an Italian family with X-linked retinitis pigmentosa (RP), detailing its distinctive genotype-phenotype correlation with pathologic myopia (PM). All members of this RP-PM family underwent a complete ophthalmic examination. The entire open reading frames of RPGR and retinitis pigmentosa 2 genes were analyzed by Sanger sequencing. A novel frame-shift mutation in exon ORF15 of RPGR gene (c...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977064/anti-vascular-endothelial-growth-factor-for-choroidal-neovascularisation-in-people-with-pathological-myopia
#20
REVIEW
Ying Zhu, Ting Zhang, Gezhi Xu, Lijun Peng
BACKGROUND: Choroidal neovascularisation (CNV) is a common complication of pathological myopia. Once developed, most eyes with myopic CNV (mCNV) experience a progression to macular atrophy, which leads to irreversible vision loss. Anti-vascular endothelial growth factor (anti-VEGF) therapy is used to treat diseases characterised by neovascularisation and is increasingly used to treat mCNV. OBJECTIVES: To assess the effects of anti-vascular endothelial growth factor (anti-VEGF) therapy for choroidal neovascularisation (CNV), compared with other treatments, sham treatment or no treatment, in people with pathological myopia...
December 15, 2016: Cochrane Database of Systematic Reviews
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