keyword
https://read.qxmd.com/read/38521423/biosimilars-of-anti-vascular-endothelial-growth-factor-for-ophthalmic-diseases-a-review
#21
REVIEW
Neil M Bressler, Peter K Kaiser, Diana V Do, Quan Dong Nguyen, Kyu Hyung Park, Se Joon Woo, Min Sagong, Mario Bradvica, Mercy Yeeun Kim, Seungkee Kim, SriniVas R Sadda
The development of intravitreally injected biologic medicines (biologics) acting against vascular endothelial growth factor (VEGF) substantially improved the clinical outcomes of patients with common VEGF-driven retinal diseases. The relatively high cost of branded agents, however, represents a financial burden for most healthcare systems and patients, likely resulting in impaired access to treatment and poorer clinical outcomes for some patients. Biosimilar medicines (biosimilars) are clinically equivalent, potentially economic alternatives to reference products...
March 21, 2024: Survey of Ophthalmology
https://read.qxmd.com/read/38521154/eight-years-and-beyond-longitudinal-changes-of-peripapillary-structures-on-oct-in-adult-myopia
#22
JOURNAL ARTICLE
Yi Dai Md PhD, Li Wang Md PhD, Jie Hong Ms, Xinghuai Sun Md PhD
PURPOSE: To investigate the long-term changes of peripapillary structures detected by enhanced depth imaging of OCT in adult myopia. DESIGN: Observational case series. METHODS: Myopic participants who had undergone a full baseline ophthalmologic examination and followed up with a minimum of 8 years were included. Using enhanced depth imaging of OCT, scans around the optic disc in the follow-up mode which enabled capturing of the same positions were performed in 65 eyes...
March 21, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38521148/edi-oct-as-an-auxiliary-examination-for-the-differential-diagnosis-of-bullous-csc-and-vogt-koyanagi-harada-a-case-report
#23
Yuanyuan Zhang, Chenwei Gui, Tianyu Wang, Jianhao Bai, Zhongqi Wan, Lei Gao, Qing Peng
A 46-year-old male patient visited our clinic with a complaint of blurred vision in the right eye accompanied by headache and insomnia. The fundus examination showed three bullous retinal detachments in the right eye. Considering the prodromal symptoms and other fundus characteristics such as vitreous cells in the posterior pole and multifocal fluorescence leakages on fundus fluorescein angiography (FFA), initial diagnosis was considered as Vogt-Koyanagi-Harada (VKH). However, oral glucocorticoids didn't improve patient's vision...
March 21, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38521134/volume-enlargement-of-the-choroid-plexus-and-brain-ventricles-in-drug-na%C3%A3-ve-first-episode-major-depressive-disorder
#24
JOURNAL ARTICLE
Gaku Hayakawa, Enkmurun Chibaatar, Keita Watanabe, Naomichi Okamoto, Patrick M Quinn, Atsuko Ikenouchi, Takahiro Shinkai, Shingo Kakeda, Reiji Yoshimura
BACKGROUND: We investigated volumetric alterations in the bilateral choroid plexus (ChP) and brain ventricles of patients during their first episode of major depressive disorder (MDD) prior to antidepressant treatment. METHODS: Seventy-one first-episode drug-naïve patients with MDD and seventy-four healthy control (HC) subjects were recruited. MRI data were obtained, and bilateral ChP and brain ventricle volumes were evaluated using segmentation, based on the adaptive multiscale and expectation maximization method...
March 21, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38518991/diagnostic-utility-of-quantiferon-gold-testing-in-patients-with-ocular-inflammation-in-a-low-endemic-tuberculosis-region
#25
JOURNAL ARTICLE
Julia Xia, Alan G Palestine, Amit K Reddy
PURPOSE: To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. DESIGN: Diagnostic utility analysis. METHODS: A review was performed for all uveitis patients who underwent QFT-G testing at the University of Colorado Eye Center from 2009-2022. Records were reviewed to assess QFT-G positivity rate and to identify which patients were tested for diagnostic purposes, defined as meeting the Standardization of Uveitis Nomenclature (SUN) criteria for tubercular uveitis (TBU): anterior uveitis with iris nodules, serpiginous-like choroiditis, choroidal nodule resembling a tuberculoma, multifocal choroiditis, or occlusive retinal vasculitis...
March 20, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38516463/longitudinal-retinal-and-choroidal-image-analysis-in-a-set-of-monozygotic-twins
#26
Angela M Hemesath, Justin P Ma, Bryce W Polascik, Dilraj Grewal, Sharon Fekrat
We analyzed multimodal retinal and choroidal imaging, including optical coherence tomography (OCT) and OCT angiography (OCTA), to assess differences and characterize variations in the retinal and choroidal structure and microvasculature between healthy monozygotic twins without ocular or systemic pathology over a five-year period. Retinal imaging of both subjects revealed normal age-related changes. There was up to an 11% difference in OCT and OCTA variables within the subjects, both at baseline and at five years, and there was up to an 18% difference in OCT and OCTA parameters between the subjects for both time points...
February 2024: Curēus
https://read.qxmd.com/read/38514123/-selection-of-appropriate-approaches-to-preserve-brain-function-for-deep-seated-brain-tumors-our-experience-of-two-posterior-thalamic-cases
#27
JOURNAL ARTICLE
Masazumi Fujii
What is the most important factor to achieve successful surgery for deep-seated brain tumors with preservation of brain functions? Definitely, it is to identify the tumor origin site at which a tumor arose and select appropriate surgical approaches that immediately lead directly to the site in the early stage of surgery, minimizing damages of cortices and important white matter bundles, and controlling main arterial supply to the tumor. For this, neurosurgeons must have thorough knowledge of brain anatomy and function, and tailor the best surgical approach for each patient, based on three-dimensional anatomical simulation...
March 2024: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/38512510/optical-coherence-tomography-angiography-suggests-choriocapillaris-perfusion-deficit-as-etiology-of-acute-macular-neuroretinopathy
#28
JOURNAL ARTICLE
Claus von der Burchard, Arved Gruben, Johann Roider
PURPOSE: Acute macular neuroretinopathy (AMN) can cause sudden-onset and permanent scotoma in healthy young patients. Analysis of optical coherence tomography (OCT) and OCT angiography (OCTA) of AMN patients may provide insights into disease mechanism. METHODS: We conducted a retrospective study of consecutive SARS-Cov-2-related AMN patients that presented in our clinic between Jan 1st, 2022, and April 30th, 2023, within 30 days of symptom onset. Retinal vessel area density (VAD) of AMN lesions in OCTA was quantified and compared to an adjacent tissue control (ATC)...
March 21, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38512284/choroidal-vascularity-index-and-choroidal-structural-changes-in-children-with-nephrotic-syndrome
#29
JOURNAL ARTICLE
Wenbo Zhang, Junmeng Li, Lei Zhu, Shuang Zeng, Yanye Lu, Yadi Zhang, Xiaopeng Gu, Hailong Wu, Liu Yang
PURPOSE: To investigate the choroidal vascularity index (CVI) and choroidal structural changes in children with nephrotic syndrome. METHODS: This was a cross-sectional study involving 45 children with primary nephrotic syndrome and 40 normal controls. All participants underwent enhanced depth imaging-optical coherence tomography examinations. An automatic segmentation method based on deep learning was used to segment the choroidal vessels and stroma, and the choroidal volume (CV), vascular volume (VV), and CVI within a 4...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38511753/comparison-of-choroidal-thickness-and-choroidal-vascular-index-in-normotensive-dippers-and-nondippers
#30
JOURNAL ARTICLE
Doğukan Cömerter, Taha Baysal, Selami Doğan, Almina Erdem, Tufan Çınar
OBJECTIVE: The aim of this study was to evaluate the choroidal thickness and choroidal vascular index in normotensive individuals with dipping and nondipping patterns. METHODS: Patients who applied to the cardiology clinic for routine checkups and underwent 24-h blood pressure monitoring were included in our study. They were divided into two groups based on their dipper status. The patients in whom systolic blood pressure decreased during the nocturnal time by 10% or more of the daily blood pressure were defined as dippers...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38510631/a-rare-trifocal-presentation-of-a-choroid-plexus-papilloma-case-report-and-review-of-the-literature
#31
REVIEW
Senne Broekx, Mania De Praeter
INTRODUCTION: CPP's present as slow-growing intraventricular neoplasms arising from epithelium of choroid plexus. They account for approximately 0.5-4% of intracranial neoplasms in adults and children, respectively. A trifocal presentation is exceedingly rare. RESEARCH QUESTION: We describe the case of a trifocal presentation of a CPP and explored the importance of genetic analyses. MATERIAL AND METHODS: We present the case of an 18-year old adolescent who was treated for a fourth ventricular and suprasellar neoplasm...
2024: Brain Spine
https://read.qxmd.com/read/38509616/uveal-effusion-syndrome-a-case-report
#32
JOURNAL ARTICLE
Brittany Hodges, Felix Omoruyi, Karen Allison
BACKGROUND: This case report is applicable to the field of ophthalmology because there is a paucity of medical literature related to the clinical presentation, diagnosis, and management of uveal effusion syndrome. This is an urgent concern because there are severe complications associated with this disease, including non-rhegmatogenous retinal detachment, angle closure glaucoma, and possible blindness. This report will fill clinical knowledge gaps using a patient example. CASE PRESENTATION: A 68-year-old white male with multiple cardiovascular risk factors initially presented to the Eye Institute Urgent Care Clinic with new onset visual symptoms, including eye pain, eye lid swelling, redness, and tearing of his left eye...
March 21, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38507191/evaluation-of-a-digital-amsler-grid-pocdoc-for-macular-disease-screening-a-comparative-analysis-with-the-conventional-method
#33
JOURNAL ARTICLE
Joewee Boon, William Rojas-Carabali, Yusra Asad, Jonathan Tzien Yih Lim, Rajesh Rajagopalan, Rupesh Agrawal
INTRODUCTION: Macular diseases are major contributors to visual impairment and blindness worldwide. This study introduces PocDoc, a digital version of the conventional Amsler grid, aimed at enhancing the screening and monitoring of macular diseases. We conducted a comprehensive evaluation to compare the effectiveness of PocDoc against the conventional method. METHODS: Our comparative analysis involved two distinct phases. Initially, we assessed the capability of both PocDoc and the conventional method in detecting central visual field abnormalities...
March 20, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38504966/choroid-and-retinal-effects-of-epilepsy-and-epilepsy-subgroups
#34
JOURNAL ARTICLE
Isil Merve Torun, Taha Baysal, Mirac Aysen Unsal, Murat Sonmez
OBJECTIVES: The objective were to evaluate structural alterations in the retina and choroid tissue of epilepsy patients and subtypes using enhanced depth imaging optic coherence tomography (EDI-OCT). METHODS: 46 epilepsy patients and 50 sex- and age-matched control patients were analyzed in the study. Patients' epilepsy types were recorded. The central macular thickness (CMT), retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and choroidal thickness (CT) were investigated through the Spectralis-OCT device (SD-OCT)...
2024: Beyoglu eye journal
https://read.qxmd.com/read/38504959/bilateral-iris-metastasis-in-a-patient-with-small-cell-lung-carcinoma-a-case-report
#35
Mukaddes Damla Ciftci, Sinan Ezirmik, Banu Yaman, Melis Palamar
Small cell lung carcinoma (SCLC) is a neuroendocrine tumor with high probability of early disseminated disease and paraneoplastic syndromes. Choroid is the most common uveal tissue affected by metastatic disease followed by iris and ciliary body. Herein, we present a 46-year-old male with bilateral multiple iris metastasis. Once diagnosed, the patient already had diagnosis of SCLC with cranial and bone metastases.
2024: Beyoglu eye journal
https://read.qxmd.com/read/38504269/clinicopathological-study-of-ophthalmic-cutaneous-and-mucocutaneous-non-langerhans-cell-histiocytic-lesions
#36
JOURNAL ARTICLE
Hind Manaa Alkatan, Dalal R Fatani, Azza M Y Maktabi, Tariq A Alzahem
BACKGROUND: The "C group" of the histiocytic disorders is characterized by non-Langerhans-cell histiocytic lesions in the skin, mucosal surfaces, or both, out of which Juvenile xanthogranuloma (JXG) is the most common typically affecting the skin. The eye is the most common extra-cutaneous site of JXG., we aim at providing our clinical and histopathological experience with this group of diseases including the adult-onset xanthogranuloma (AXG). METHODS: This is a retrospective cohort study of all patients with the tissue diagnosis of ocular and periocular cutaneous and mucocutaneous non-LCH disorders who presented to us over a period of 25 years (January 1993 to December 2018)...
March 19, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38502258/diagnostic-and-therapeutic-considerations-in-patients-with-bilateral-diffuse-uveal-melanocytic-proliferation
#37
REVIEW
Dimitrios Kalogeropoulos, Farid Afshar, Gabriella De Salvo, Christina A Rennie, Andrew John Lotery
PURPOSE: This review aims to summarize the current knowledge concerning the clinical features, diagnostic work-up, and therapeutic approach of bilateral diffuse uveal melanocytic proliferation (BDUMP). METHODS: A meticulous literature search was performed in the PubMed database. A supplementary search was made in Google Scholar to complete the collected items. Our search strategy utilized the following keywords: "bilateral diffuse uveal melanocytic proliferation", "BDUMP", and "Paraneoplastic Syndrome"...
March 19, 2024: International Ophthalmology
https://read.qxmd.com/read/38500936/ventriculoperitoneal-shunt-failure-and-cerebrospinal-fluid-protein-a-meta-analysis-and-systematic-review
#38
REVIEW
Kyle M Rei, Muhammad S Ghauri, Mohammed B Uddin, Javed Siddiqi
Ventriculoperitoneal shunts (VPS) are used to manage hydrocephalus but suffer from high failure rates. Our objectives were to (1) conduct a meta-analysis to objectively weigh this conflicting evidence, and (2) conduct a systematic review compiling and synthesizing what is known about the association between CSF proteins and shunt failure. A literature search was performed in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Embase, PubMed, and CENTRAL databases were searched from inception to June 2023...
February 2024: Curēus
https://read.qxmd.com/read/38499856/the-potential-key-role-of-choroidal-non-perfusion-and-rod-degeneration-in-the-pathogenesis-of-macular-neovascularization-type-3
#39
REVIEW
Bilal Haj Najeeb, Ursula Schmidt-Erfurth
Macular neovascularization type 3 (MNV3) is a multifactorial disease with distinct epidemiological, clinical, pathomorphological and topographical characteristics. This review of the literature discusses the latest experimental and clinical outcomes that could explain the pathogenesis of retinal neovascularization. Although patients with MNV3 are usually older than those with MNV1 or 2, their lesions do not coexist with, precede, or follow other types in the same eye. The regional distribution of MNV3 lesions is characterized as confined to the parafoveal macula without any involvement of the rod-free foveal area...
March 18, 2024: Eye
https://read.qxmd.com/read/38499842/gnt-v-mediated-aberrant-n-glycosylation-of-timp-1-promotes-diabetic-retinopathy-progression
#40
JOURNAL ARTICLE
Xiaoting Xi, Yanni Yang, Qianbo Chen, Jia Ma, Xuewei Wang, Yachun Deng, Xi Wang, Yan Li
BACKGROUND: Vascular endothelial growth factor (VEGF) signaling pathway plays an important role in the progression of diabetic retinopathy (DR). The glycosylation modification process of many key functional proteins in DR patients is abnormal. However, the potential involvement of abnormal N-glycoproteins in DR progression remains unclear. METHODS: Glycoproteomic profiling of the vitreous humor was performed. The level of protein and N-glycoprotein was confirmed by Western blot and Lectin blot, respectively...
March 18, 2024: Molecular Biology Reports
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