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https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#1
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29682574/baseline-predictors-of-visual-acuity-outcome-in-patients-with-wet-age-related-macular-degeneration
#2
REVIEW
Xinyuan Zhang, Timothy Y Y Lai
Age-related macular degeneration (AMD) is one of the leading causes of severe vision loss in people over 60 years. Wet AMD (wAMD) causes more severe visual acuity (VA) loss compared with the dry form due to formation of choroidal neovascularization (CNV). Antivascular endothelial growth factor (anti-VEGF) agents such as ranibizumab and aflibercept are now the standard of care treatment for wAMD. Unfortunately, up to a quarter of anti-VEGF-treated wAMD patients might not fully benefit from intravitreal injections and CNV activity may not respond to the treatment and these patients are called anti-VEGF nonresponders...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682078/a-case-of-vago-glossopharyngeal-neuralgia-caused-by-choroid-plexus
#3
Ali Akay, Mete Rükşen, Sertaç İşlekel
Vascular compression has been reported to be the most common reason for vago-glossopharyngeal neuralgia (VGN). The treatment may include medications, ganglion blockade with a radiofrequency ablation, and microvascular decompression (MVD). A review of the literature reveals that VGN may develop due to choroid plexus compression, and the number of reported cases is very limited. The current case is the fifth in the relevant literature. In this paper, choroid plexus compression has been shown intraoperatively during the treatment of rare idiopathic VGN using MVD...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682069/ruptured-distal-anterior-choroidal-artery-aneurysm-presenting-as-isolated-intraventricular-hemorrhage-case-report-and-comprehensive-review-of-the-literature
#4
Chi Hau Tan, Leon T Lai, Ronil V Chandra
Distal anterior choroidal artery (AChA) aneurysms are infrequent. We discuss the case of a 59-year-old patient who presented with an isolated intraventricular hemorrhage (IVH) secondary to a ruptured distal AChA aneurysm. Initial noninvasive cerebral computed tomography angiography revealed no evidence of an underlying vascular pathology. The patient underwent further digital subtraction cerebral angiography, which revealed an aneurysm arising from the distal AChA segment. The aneurysm was successfully treated with surgical clip ligation...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682048/choroidal-type-of-vein-of-galen-aneurysmal-malformation-in-adult-patient-with-unusual-presentation-of-orthostatic-headache
#5
Kapil Pareek, Trilochan Shrivastava, Virendra Deo Sinha
Vein of Galen aneurysmal malformations (VGAMs) are rare vascular malformations occurring commonly in the pediatric age group. They comprise only 1% of all intracranial vascular malformations, but in pediatric population, they represent 30% of all intracranial vascular malformations. They are of two types-mural and choroidal. Choroidal type of VGAM is more primitive and most severe form of disease. It usually causes high cardiac output failure in newborn period because of multiple high flow fistulas. Adult presentation of choroidal type VGAM is very rare, and only few cases have been reported in literature so far...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#6
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681832/one-year-outcome-of-aflibercept-and-photodynamic-therapy-in-a-caucasian-patient-with-polypoidal-choroidal-vasculopathy-refractory-to-ranibizumab-and-photodynamic-therapy
#7
Marta Medina-Baena, María Jesús Huertos-Carrillo, Laura Rodríguez, Juan Ignacio García-Pulido, Carlos Cornejo-Castillo, José María Calandria-Amiguetti
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration characterised by an abnormal branching vascular network with aneurysmal polypoidal choroidal vascular lesions. PCV is more prevalent in Asian populations than in Caucasians, which may explain its underdiagnosis in Western countries. Evidence regarding the efficacy of different anti-vascular endothelial growth factor (anti-VEGF) agents on PCV is scarce, with most of these studies being conducted in Asian treatment-naïve patients...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681825/arterial-spin-labeling-imaging-of-a-giant-aneurysm-leading-to-subarachnoid-hemorrhage-following-cerebral-infarction
#8
Tatsuya Ueno, Tatsuya Sasaki, Masatoshi Iwamura, Tomoya Kon, Jin-Ichi Nunomura, Hiroshi Midorikawa, Masahiko Tomiyama
An 83-year-old Japanese man was admitted with dysarthria and right hemiparesis. He had had a large intracranial aneurysm on the left internal carotid artery 5 years before admission and had been followed up under conservative treatment. On admission, diffusion-weighted imaging revealed a hyperintense signal on the left anterior choroidal artery territory. Time-of-flight magnetic resonance angiography demonstrated poor visibility of the middle and anterior cerebral arteries and the inferior giant aneurysm, suggesting distal emboli from aneurysm thrombosis or a reduction of blood outflow due to aneurysm thrombosis...
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29681725/the-effects-of-bevacizumab-treatment-in-a-rat-model-of-retinal-ischemia-and-perfusion-injury
#9
Maryo Cenk Kohen, Sinan Tatlipinar, Alev Cumbul, Ünal Uslu
Purpose: To create a model of an ischemic retina with temporary ischemia and reperfusion (IR) and to examine the possible antiapoptotic and neurodegenerative effects of a vascular endothelial growth factor (VEGF) antagonist. Methods: Three groups were formed. Rats were subjected to continued ischemia for 45 min, and then reperfusion was allowed for 2 days. For the first group, ischemia was induced, but an anti-VEGF agent was not administered. For the second group, 2 days before ischemia, 0...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29681297/predicting-choroidal-melanoma-regression-after-brachytherapy
#10
EDITORIAL
Bertil Damato
No abstract text is available yet for this article.
May 2018: Ophthalmology
https://www.readbyqxmd.com/read/29680322/dose-response-in-choroidal-melanoma
#11
Alex De Caluwé, Karolien Termote, Dirk Van Gestel, Erik Van Limbergen
PURPOSE: In choroidal melanoma the radiation threshold dose for local control remains largely unknown. The present study examined a group of patients that received a wide range of minimum tumor dose in order to investigate a dose-response relationship. A literature review is performed to compare our results with available evidence in brachytherapy and charged particle external beam radiotherapy. MATERIALS AND METHODS: A retrospective study was conducted on all choroidal melanomas treated with Strontium-90 (Sr-90) at the University Hospital of Leuven between 1983 and 2012...
April 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29679669/n-acetylcysteine-protects-against-chorioretinal-damage-induced-by-photodynamic-therapy-for-experimental-choroidal-neovascularization-in-a-rat-model
#12
Tae Wan Kim, Jun Woong Moon, Hyeong Gon Yu
We explored the protective effects of N -acetylcysteine (NAC) on chorioretinal damage induced by photodynamic therapy (PDT) in an experimental rat model of choroidal neovascularization (CNV). METHODS: Experimental CNV was induced by an argon laser in 24 Brown Norway rats 7 days prior to PDT. Commencing 1 day after CNV induction, 0.5 mL of NAC was orally administered daily to the NAC+ group (12 rats), and 0.5 mL of normal saline to the NAC- group (12 rats). Diode laser treatment was delivered for 42 s (total energy, 25 J/cm2) to the left eye prior to verteporfin infusion (PDT-) and to the right eye 15-20 min after such infusion (PDT+)...
April 18, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#13
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29678603/chebulagic-acid-chebulinic-acid-and-gallic-acid-the-active-principles-of-triphala-inhibit-tnf%C3%AE-induced-pro-angiogenic-and-pro-inflammatory-activities-in-retinal-capillary-endothelial-cells-by-inhibiting-p38-erk-and-nfkb-phosphorylation
#14
Sivasankar Shanmuganathan, Narayanasamy Angayarkanni
Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and neovascular age related macular degeneration (NV-AMD). Hence, inhibition of TNFα mediated changes can benefit the management of DR and NV-AMD. Triphala, an ayurvedic herbal preparation is known to have immunomodulatry functions. In this study we evaluated the alcoholic extract of triphala (AlE) and its compounds Chebulagic acid (CA), Chebulinic acid (CI) and Gallic acid (GA) for their anti-TNFα activity...
April 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29678592/retina-compatible-interactions-and-effective-modulation-of-blood-ocular-barrier-p-gp-activity-by-third-generation-inhibitors-improves-ocular-penetration-of-loperamide
#15
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P Lamichhane, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar
Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance (MDR) efflux proteins, beside tight junction proteins, in the blood ocular barriers (BOB). Hence, the purpose of the current research was to investigate the ability of the third-generation efflux protein inhibitors, elacridar (EQ) and tariquidar (TQ), to diminish P-glycoprotein (P-gp) mediated efflux transport of loperamide (LOP), a P-gp substrate, across the BOB in SD rats...
April 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29677375/characteristics-of-retinal-structural-and-microvascular-alterations-in-early-type-2-diabetic-patients
#16
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677362/deep-layer-microvasculature-dropout-by-optical-coherence-tomography-angiography-and-microstructure-of-parapapillary-atrophy
#17
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Tadamichi Akagi, Alberto Diniz-Filho, Luke Saunders, Robert N Weinreb
Purpose: To investigate the association between the microstructure of β-zone parapapillary atrophy (βPPA) and parapapillary deep-layer microvasculature dropout assessed by optical coherence tomography angiography (OCT-A). Methods: Thirty-seven eyes with βPPA devoid of the Bruch's membrane (BM) (γPPA) ranging between completely absent and discontinuous BM were matched by severity of the visual field (VF) damage with 37 eyes with fully intact BM (βPPA+BM) based on the spectral-domain (SD) OCT imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677356/volume-rendered-projection-resolved-oct-angiography-3d-lesion-complexity-is-associated-with-therapy-response-in-wet-age-related-macular-degeneration
#18
Peter L Nesper, Brian T Soetikno, Alison D Treister, Amani A Fawzi
Purpose: To explore whether quantitative three-dimensional (3D) analysis of choroidal neovascularization (CNV) using projection-resolved optical coherence tomography angiography (PR-OCTA) is associated with treatment response in neovascular age-related macular degeneration (nAMD). Methods: Retrospective, cross-sectional study of 51 eyes of 49 patients undergoing individualized anti-VEGF therapy for nAMD. Patients were classified as "good" or "poor" responders, requiring injections at less or more frequently than 6-week intervals, respectively...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29676172/macular-telangiectasia-type-ii-with-pachychoroid-spectrum-of-macular-disorders
#19
Vinod Kumar, Pradeep Kumar, Raghav Ravani, Prasad Gupta
PURPOSE: To report the cases with features of macular telangiectasia type II and pachychoroid spectrum of macular disorders simultaneously. METHODS: It is a retrospective case series from a tertiary eye care center. Multimodal imaging features of these eyes including color fundus photographs, red free imaging, short-wave autofluorescence, fundus fluorescein angiography, indocyanine green angiography, and optical coherence tomography were studied. RESULTS: Six eyes of three patients having combination of macular telangiectasia type II and pachychoroid group of disorders were found...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675907/age-related-scattered-hypofluorescent-spots-on-late-phase-indocyanine-green-angiography-the-multimodal-imaging-and-relevant-factors
#20
Ling Chen, Xiongze Zhang, Bing Liu, Lan Mi, Feng Wen
IMPORTANCE: Fundus aging and its imaging features BACKGROUND: To characterize the demographic and multimodal-imaging features of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA). DESIGN: A hospital-based retrospective study. PARTICIPANTS: 875 normal fundi fellow eyes from 875 patients underwent indocyanine green angiography (ICGA), fluorescence angiography (FA), autofluorescence (AF) and spectral-domain optical coherence tomography (OCT)...
April 19, 2018: Clinical & Experimental Ophthalmology
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