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Separation Anxiety

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https://www.readbyqxmd.com/read/29156991/repeated-mild-traumatic-brain-injury-produces-neuroinflammation-anxiety-like-behaviour-and-impaired-spatial-memory-in-mice
#1
John I Broussard, Laura Acion, Héctor De Jesús-Cortés, Terry Yin, Jeremiah K Britt, Ramiro Salas, Mauro Costa-Mattioli, Claudia Robertson, Andrew A Pieper, David B Arciniegas, Ricardo Jorge
PRIMARY OBJECTIVE: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. RESEARCH DESIGN: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29143890/paternal-anxiety-in-relation-to-toddler-anxiety-the-mediating-role-of-maternal-behavior
#2
Robert C Gibler, Anne E Kalomiris, Elizabeth J Kiel
Despite robust investigations examining the impact of maternal anxiety and parenting behaviors and child anxiety risk, less is understood about the impact of paternal anxiety and parenting behaviors on child anxiety risk, particularly within the broader family context. An Actor Partner Interdependence Model (APIM) was used to examine whether paternal anxiety longitudinally predicted child anxiety risk indirectly through maternal and paternal parenting behaviors, while controlling for maternal anxiety. Both fathers and mothers of 12- to 30-month-olds (n = 94) provided self-report of their anxiety and parenting behaviors...
November 16, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29143889/beyond-pathologizing-harm-understanding-ptsd-in-the-context-of-war-experience
#3
Patricia Benner, Jodi Halpern, Deborah R Gordon, Catherine Long Popell, Patricia W Kelley
An alternative to objectifying approaches to understanding Post-traumatic Stress Disorder (PTSD) grounded in hermeneutic phenomenology is presented. Nurses who provided care for soldiers injured in the Iraq and Afghanistan wars, and sixty-seven wounded male servicemen in the rehabilitation phase of their recovery were interviewed. PTSD is the one major psychiatric diagnosis where social causation is established, yet PTSD is predominantly viewed in terms of the usual neuro-physiological causal models with traumatic social events viewed as pathogens with dose related effects...
November 16, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29136515/associations-between-feelings-of-social-anxiety-and-emotion-perception
#4
Spencer K Lynn, Eric Bui, Susanne S Hoeppner, Emily B O'Day, Sophie A Palitz, Lisa Feldman Barrett, Naomi M Simon
BACKGROUND: Abnormally biased perceptual judgment is a feature of many psychiatric disorders. Thus, individuals with social anxiety disorder are biased to recall or interpret social events negatively. Cognitive behavioral therapy addresses such bias by teaching patients, via verbal instruction, to become aware of and change pathological misjudgment. The present study examined whether targeting verbal instruction to specific decision parameters that influence perceptual judgment may affect changes in anger perception...
October 4, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29132110/comprehensive-phospholipid-and-sphingomyelin-profiling-of-different-brain-regions-in-mouse-model-of-anxiety-disorder-using-online-two-dimensional-hilic-rp-lc-ms-method
#5
Róbert Berkecz, Ferenc Tömösi, Tímea Körmöczi, Viktor Szegedi, János Horváth, Tamás Janáky
A novel online system including two-dimensional liquid chromatography coupled to high-resolution mass spectrometry (2D-LC/MS) was developed and applied for comprehensive phospholipid (PL) and sphingomyelin (SM) profiling of dorsal hippocampus (DHPC), ventral (VHPC) and prefrontal cortex (PFC) brain regions in a mouse model of anxiety disorder. In the first dimension, lipid classes were distinguished by hydrophilic interaction liquid chromatography (HILIC), while the second dimensional separation of individual PL and SM species was achieved by reversed-phase (RP) chromatography...
November 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29124290/predicting-psychiatric-readmission-sex-specific-models-to-predict-30-day-readmission-following-acute-psychiatric-hospitalization
#6
Lucy Church Barker, Andrea Gruneir, Kinwah Fung, Nathan Herrmann, Paul Kurdyak, Elizabeth Lin, Paula A Rochon, Dallas Seitz, Valerie H Taylor, Simone N Vigod
PURPOSE: Psychiatric readmission is a common negative outcome. Predictors of readmission may differ by sex. This study aimed to derive and internally validate sex-specific models to predict 30-day psychiatric readmission. METHODS: We used population-level health administrative data to identify predictors of 30-day psychiatric readmission among women (n = 33,353) and men (n = 32,436) discharged from all psychiatric units in Ontario, Canada (2008-2011). Predictor variables included sociodemographics, health service utilization, and clinical characteristics...
November 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29123215/observer-s-anxiety-facilitates-magnocellular-processing-of-clear-facial-threat-cues-but-impairs-parvocellular-processing-of-ambiguous-facial-threat-cues
#7
Hee Yeon Im, Reginald B Adams, Jasmine Boshyan, Noreen Ward, Cody A Cushing, Kestutis Kveraga
Facial expression and eye gaze provide a shared signal about threats. While a fear expression with averted gaze clearly points to the source of threat, direct-gaze fear renders the source of threat ambiguous. Separable routes have been proposed to mediate these processes, with preferential attunement of the magnocellular (M) pathway to clear threat, and of the parvocellular (P) pathway to threat ambiguity. Here we investigated how observers' trait anxiety modulates M- and P-pathway processing of clear and ambiguous threat cues...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29120948/parvalbumin-containing-gaba-cells-and-schizophrenia-experimental-model-based-on-targeted-gene-delivery-through-adeno-associated-viruses
#8
Marta U Woloszynowska-Fraser, Peer Wulff, Gernot Riedel
Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29118713/corticotropin-releasing-factor-in-the-bed-nucleus-of-the-stria-terminalis-in-socially-defeated-and-non-stressed-mice-with-a-history-of-chronic-alcohol-intake
#9
Lucas Albrechet-Souza, Thiago W Viola, Rodrigo Grassi-Oliveira, Klaus A Miczek, Rosa M M de Almeida
Stress exposure has been identified as one risk factor for alcohol abuse that may facilitate the transition from social or regulated use to the development of alcohol dependence. Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. The bed nucleus of the stria terminalis (BNST) contains CRF-producing neurons which seem to be sensitive to stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29114559/demographic-and-psychological-predictors-of-recovery-from-coronary-artery-bypass-graft
#10
Mehran Sadeghi, Mohammad Hashemi, Reza Bagherian Sararoudi, Mohammad Reza Merasi, Mitra Molaeinezhad, Hamid Shamsolketabi
OBJECTIVES: Worldwide, i.e. in Iran, coronary artery bypass grafting (CABG) is one of the most common and expensive surgeries. This study was designed to explore the demographic and psychological factors which predict the recovery process in CABG patients. MATERIALS AND METHODS: During a prospective correlational study, 250 CABG patients, in two public and private hospitals, investigated for indexes of recovery during hospital stay and 4 weeks after discharge. Demographic and psychological variables were collected through checklist and Farsi validated and reliable versions of type D personality, the multidimensional scale of perceived social support, revised illness perception questionnaire (IPQ-R)...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29114273/formulation-and-characterization-of-nanomedicine-solid-lipid-nanoparticle-associate-with-the-extract-of-pterospermum-acerifolium-for-the-screening-of-neurochemicals-and-neuroendocrine-effects
#11
Ankur Choubey, Ritu Gilhotra, Santosh Kumar Singh, Gopal Garg
Background: Nanotechnology has given the likelihood of conveying medications to particular cells utilizing nanoparticles. Nanosystems can convey the dynamic constituent at an adequate fixation amid the whole treatment time frame, guiding it to the fancied site of activity. Traditional medications do not meet these necessities. The fundamental motivation behind creating elective medication conveyance advancements is to expand effectiveness of medication conveyance and security during the time spent medication conveyance and give more accommodation to the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29114211/microglial-over-activation-by-social-defeat-stress-contributes-to-anxiety-and-depressive-like-behaviors
#12
REVIEW
Dirson J Stein, Mailton F Vasconcelos, Lucas Albrechet-Souza, Keila M M Ceresér, Rosa M M de Almeida
Hyper activation of the neuroimmune system is strongly related to the development of neuropsychiatric disorders. Psychosocial stress has been postulated to play an important role in triggering anxiety and major depression. In preclinical models, there is mounting evidence that social defeat stress activates microglial cells in the central nervous system. This type of stress could be one of the major factors in the development of these psychopathologies. Here, we reviewed the most recent literature on social defeat and the associated immunological reactions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29113737/voluntary-alcohol-intake-after-noise-exposure-in-adolescent-rats-hippocampal-related-behavioral-alterations
#13
M Miceli, S J Molina, A Forcada, G B Acosta, L R Guelman
Different physical or chemical agents, such as noise or alcohol, can induce diverse behavioral and biochemical alterations. Considering the high probability of young people to undergo a successive or simultaneous exposure, the aim of the present work was to investigate in an animal model if noise exposure at early adolescence could induce hippocampal-related behavioral changes that might be modified after alcohol intake. MaleWistarrats(28-days-old)were exposed tonoise(95-97 dB, 2 h).Afterwards, animals were allowed to voluntarily drink alcohol(10% ethanol in tap water)for three consecutive days, using the two-bottle free choice paradigm...
November 4, 2017: Brain Research
https://www.readbyqxmd.com/read/29112884/appearance-based-rejection-sensitivity-as-a-mediator-of-the-relationship-between-symptoms-of-social-anxiety-and-disordered-eating-cognitions-and-behaviors
#14
Jake Linardon, Rachel Braithwaite, Rachel Cousins, Leah Brennan
Previous research has established a robust relationship between symptoms of social anxiety and disordered eating. However, the mechanisms that may underpin this relationship are unclear. Appearance-based rejection sensitivity (ABRS)-the tendency to anxiously expect and overreact to signs of appearance-based rejection-may be a crucial explanatory mechanism, as ABRS has been shown to maintain social anxiety symptoms and predict disordered eating. We therefore tested whether ABRS mediated the relationship between social anxiety symptoms and various indices of disordered eating (over-evaluation of weight/shape, restraint, binge eating, compulsive exercise, and vomiting)...
October 31, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29108803/factor-analysis-of-symptom-dimensions-psychotic-affective-and-obsessive-compulsive-symptoms-in-schizophrenia
#15
Sandeep Grover, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
AIM: To carryout factor analysis of symptom profile of patients with schizophrenia assessed by using positive and negative syndrome scale (PANSS), Calgary depression rating scale (CDSS), Young mania rating scale (YMRS) and YBOCS checklist. METHODOLOGY: 181 patients of schizophrenia were assessed on PANSS, CDSS, YMRS and YBOCS checklist. RESULTS: Factor analysis of PANSS yielded 3 factor structure (positive, negative, anxiety). When the items of CDSS were added to the PANSS items, total number of factors increased to 4 with depression emerging as a separate factor...
October 23, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29107042/measuring-participation-after-stroke-in-africa-development-of-the-participation-measurement-scale
#16
Oyéné Kossi, Félix Nindorera, Charles Sèbiyo Batcho, Thierry Adoukonou, Massimo Penta, Jean-Louis Thonnard
OBJECTIVE: To develop a valid stroke-specific tool for the measurement of participation in Africa, named the Participation Measurement Scale (PM-Scale). DESIGN: Observational study and questionnaire development. SETTING: Outpatient Rehabilitation centers. PARTICIPANTS: Stroke patients (N = 276); mean age ± standard deviation of 58.5 ± 11.1 years; 57% male. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Participants completed a 100-item experimental questionnaire of the PM-Scale...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29104331/experiential-avoidance-and-bordering-psychological-constructs-as-predictors-of-the-onset-relapse-and-maintenance-of-anxiety-disorders-one-or-many
#17
Philip Spinhoven, Albert M van Hemert, Brenda W J H Penninx
To investigate (a) the incremental predictive validity of experiential avoidance over and above bordering psychological constructs (i.e., rumination, worry, neuroticism and anxiety sensitivity) in predicting onset, relapse and maintenance of anxiety disorders; and (b) whether these related constructs can be represented by a single, higher-order latent factor with similar predictive power as the separate psychological constructs while offering a more parsimonious predictive model. Longitudinal cohort study with repeated assessments after 4 years in a sample of 2157 adults aged 18-65, consisting of 1614 persons with past or current anxiety disorder (Panic Disorder with or without Agoraphobia, Social Anxiety Disorder, Generalized Anxiety Disorder, Agoraphobia without panic) according to the Composite Interview Diagnostic Instrument (CIDI) and 543 controls...
2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/29099625/prevalence-of-depression-and-anxiety-among-bisexual-people-compared-to-gay-lesbian-and-heterosexual-individuals-a-systematic-review-and-meta-analysis
#18
Lori E Ross, Travis Salway, Lesley A Tarasoff, Jenna M MacKay, Blake W Hawkins, Charles P Fehr
Over the past decade, evidence has accumulated to suggest that bisexual people experience higher rates of poor mental health outcomes compared to both heterosexual and gay/lesbian individuals. However, no previous meta-analyses have been conducted to establish the magnitude of these disparities. To address this research gap, we conducted a systematic review and meta-analysis of studies that reported bisexual-specific data on standardized measures of depression or anxiety. Of the 1,074 full-text articles reviewed, 1,023 were ineligible, predominantly because they did not report separate data for bisexual people (n = 562 studies)...
November 3, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29096207/avoidant-personality-disorder-and-social-phobia-does-mindreading-make-the-difference
#19
Giovanni Pellecchia, Fabio Moroni, Livia Colle, Antonio Semerari, Antonino Carcione, Teresa Fera, Donatella Fiore, Giuseppe Nicolò, Roberto Pedone, Michele Procacci
OBJECTIVE: Avoidant personality disorder (AvPD) is closely related to and partially overlaps with social phobia (SP). There is an ongoing debate as to whether AvPD and SP can be classified as separate and distinct disorders or whether these diagnoses rather reflect different degrees of severity of social anxiety. The hypothesis of this study is that in patients with AvPD and in those with AvPD and comorbid SP both interpersonal functioning and metacognitive abilities (the ability to understand mental states) are more severely impaired than they are in patients with SP only...
September 28, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29083538/functional-dyspepsia-and-duodenal-eosinophilia-a-new-disease-model
#20
REVIEW
Kening Fan, Nicholas J Talley
Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the conceptual underpinning of FD has begun to change, and new data are unraveling the underlying pathophysiological mechanisms of this disorder with a focus on the duodenum. The Rome IV criteria were published in 2016, and notably suggests that gastroesophageal reflux disease and irritable bowel syndrome may all be part of the same disease spectrum as FD. Helicobacter pylori explains a minority of FD cases and in Rome IV is considered a separate entity...
October 30, 2017: Journal of Digestive Diseases
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