Camille Fédou, Mylène Camus, Ophélie Lescat, Guylène Feuillet, Ilka Mueller, Bryony Ross, Marie Buléon, Eric Neau, Melinda Alves, Dominique Goudounéche, Benjamin Breuil, Franck Boizard, Quentin Bardou, Audrey Casemayou, Ivan Tack, Sophie Dreux, Julie Batut, Patrick Blader, Odile Burlet-Schiltz, Stéphane Decramer, Brunhilde Wirth, Julie Klein, Jean Sébastien Saulnier-Blache, Bénédicte Buffin-Meyer, Joost P Schanstra
Congenital anomalies of the kidney and the urinary tract (CAKUT) are the first cause of chronic kidney disease in childhood. Several genetic and environmental origins are associated with CAKUT, but most pathogenic pathways remain elusive. Considering the amniotic fluid (AF) composition as a proxy for fetal kidney development, we analyzed the AF proteome from non-severe CAKUT (n=19), severe CAKUT (n=14), and healthy control (n=22) fetuses using LC-MS/MS. We identified 471 significant proteins that discriminated the 3 AF groups with 81% precision...
May 13, 2021: Journal of Pathology