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https://www.readbyqxmd.com/read/29868715/an-experimental-test-of-the-effectivess-of-unsolicited-reporting-by-a-prescription-drug-monitoring-program-in-reducing-inappropriate-acquisition-of-opioids
#1
Douglas C McDonald, Kenneth E Carlson, Sarah Kuck Jalbert
Objectives: This research looked at whether notifying prescribers and pharmacies about patients who use multiple providers to obtain opioids reduces their prescribing activity (including use of multiple providers, numbers of opioid prescriptions, or amounts of opioids obtained). Design: Nevada's prescription drug monitoring program (PDMP) identified patients using multiple providers to obtain opioids and assigned them alternately to an intervention or control group...
May 30, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29863921/four-states-with-robust-prescription-drug-monitoring-programs-reduced-opioid-dosages
#2
Rebecca L Haffajee, Michelle M Mello, Fang Zhang, Alan M Zaslavsky, Marc R Larochelle, J Frank Wharam
State prescription drug monitoring programs (PDMPs) aim to reduce risky controlled-substance prescribing, but early programs had limited impact. Several states implemented robust features in 2012-13, such as mandates that prescribers register with the program and regularly check its registry database. Some states allow prescribers to fulfill the latter requirement by designating delegates to check the registry. The effects of robust PDMP features have not been fully assessed. We used commercial claims data to examine the effects of implementing robust PDMPs in four states on overall and high-risk opioid prescribing, comparing those results to trends in similar states without robust PDMPs...
June 2018: Health Affairs
https://www.readbyqxmd.com/read/29801093/association-between-prescription-drug-monitoring-programs-and-nonfatal-and-fatal-drug-overdoses-a-systematic-review
#3
David S Fink, Julia P Schleimer, Aaron Sarvet, Kiran K Grover, Chris Delcher, Alvaro Castillo-Carniglia, June H Kim, Ariadne E Rivera-Aguirre, Stephen G Henry, Silvia S Martins, Magdalena Cerdá
Background: Prescription drug monitoring programs (PDMPs) are a key component of the president's Prescription Drug Abuse Prevention Plan to prevent opioid overdoses in the United States. Purpose: To examine whether PDMP implementation is associated with changes in nonfatal and fatal overdoses; identify features of programs differentially associated with those outcomes; and investigate any potential unintended consequences of the programs. Data Sources: Eligible publications from MEDLINE, Current Contents Connect (Clarivate Analytics), Science Citation Index (Clarivate Analytics), Social Sciences Citation Index (Clarivate Analytics), and ProQuest Dissertations indexed through 27 December 2017 and additional studies from reference lists...
May 8, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29778769/mandatory-review-of-a-prescription-drug-monitoring-program-and-impact-on-opioid-and-benzodiazepine-dispensing
#4
Erin L Winstanley, Yifan Zhang, Rebecca Mashni, Sydney Schnee, Jonathan Penm, Jill Boone, Cameron McNamee, Neil J MacKinnon
BACKGROUND: The purpose of this study is to determine whether Ohio House Bill 341, which mandated the use of Ohio's Prescription Drug Monitoring Program (PDMP), was an effective regulatory strategy to reduce opioid and benzodiazepine dispensing. METHOD: Secondary analysis of Ohio's PDMP data on prescription opioids and benzodiazepines dispensed from November 2014 to March 2017. An interrupted time series analysis was conducted to determine if there was a significant change in the quantity of opioids and benzodiazepines dispensed...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29762757/how-are-real-time-opioid-prescribing-cognitions-by-emergency-providers-influenced-by-reviewing-the-state-prescription-drug-monitoring-program
#5
Aaron Landau, Michael Lynch, Clifton Callaway, Brian Suffoletto
Objective: To understand how real-time opioid prescribing cognitions by emergency medicine (EM) providers are influenced by review of the state prescription drug monitoring program (PDMP). Methods: We collected prospective data from a convenience sample of 103 patient encounters for pain from 23 unique EM providers. After seeing the patient, before and immediately after reviewing the PDMP, EM providers answered how much they thought "the patient need[ed] an opioid to help manage their pain?", how concerned they were "about drug abuse and/or diversion?", and whether they planned to prescribe an opioid (yes/no)...
May 11, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29757920/alaska-nurse-practitioners-barriers-to-use-of-prescription-drug-monitoring-programs
#6
Heath Christianson, Elizabeth Driscoll, Aicha Hull
BACKGROUND AND PURPOSE: Prescription drug monitoring programs (PDMPs) have begun to demonstrate themselves as useful tools in enhancing safe and responsible prescription of controlled substances. The purpose of this project was to describe current practice, beliefs, and barriers of Alaska nurse practitioners (NPs) regarding the Alaska PDMP. METHODS: A questionnaire was sent to 635 Alaskan NPs with a 33% return rate. The data depicted prescribing habits, barriers to use, barriers to registering, and opinions on how to make the PDMP more clinically useful...
January 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29733095/assessment-of-outcomes-following-high-dose-opioid-tapering-in-a-veterans-healthcare-system
#7
Lauren Hundley, Shelley Spradley, Scott Donelenko
OBJECTIVE: To assess the impact of tapering of chronic high dose opioid therapy in veterans prompted by the implementation of the Opioid Safety Initiative in 2013. DESIGN: IRB and VA Office of Research and Development-approved retrospective, observational chart review. SETTING: North Florida/South Georgia Veterans Health System Patients: Veterans on high dose opioid therapy (≥300 mg of morphine equivalents per day) for chronic non-cancer pain as of 1/1/2012 with an opioid agreement discontinuation note documented in the medical record were included...
March 2018: Journal of Opioid Management
https://www.readbyqxmd.com/read/29703240/temporal-phenotyping-of-circulating-microparticles-after-trauma-a-prospective-cohort-study
#8
Matthias Fröhlich, Nadine Schäfer, Michael Caspers, Julia K Böhm, Ewa K Stürmer, Bertil Bouillon, Marc Maegele
BACKGROUND: After severe polytrauma the dynamic process of coagulation may deteriorate towards a trauma-induced coagulopathy (TIC) promoting a dramatic increase in morbidity and mortality. Recent evidence suggests that microparticles (MPs) play a pivotal role at the interface between cellular and plasmatic coagulation systems. However, the impact of MPs on functional coagulation has not been clarified yet in the setting of traumatic injuries. We assessed the temporal patterns of circulating MP concentrations including their cellular origin in the context of clinical presentation and global coagulation assays...
April 27, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29677414/a-multistep-approach-to-address-clinican-knowledge-attitudes-and-behavior-around-opioid-prescribing
#9
Sara Kohlbeck, Brenna Akert, Caroline Pace, Amy Zosel
INTRODUCTION: The Wisconsin Prescription Drug Monitoring Program (PDMP) was implemented in 2013 to reduce the misuse, abuse, and diversion of controlled substance prescriptions. OBJECTIVE: To evaluate provider knowledge, attitudes, and behaviors regarding the Wisconsin PDMP before and after study interventions. METHODS: An initial survey of clinicians, a focus group, pre- and posttests for an educational session, and a 3-month follow-up survey were utilized...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29618620/orthoxenografts-of-testicular-germ-cell-tumors-demonstrate-genomic-changes-associated-with-cisplatin-resistance-and-identify-pdmp-as-a-re-sensitizing-agent
#10
Josep Maria Piulats, August Vidal, Francisco J García-Rodríguez, Clara Muñoz, Marga Nadal, Catia Moutinho, Maria Martínez-Iniesta, Josefina Mora, Agnes Figueras, Elisabet Guinó, Laura Padullés, Àlvaro Aytés, David G Mollevi, Sara Puertas, Carmen Martínez-Fernández, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificacion Muñoz, Milica Stefanovic, Miguel Angel Pujana, Enric Condom, Manel Esteller, Josep R Germà-LLuch, Gabriel Capella, Lourdes Farré, Albert Morales, Francesc Viñals, Xavier Garcia Del Muro, Julián Cerón, Alberto Villanueva
PURPOSE: To investigate the genetic basis of cisplatin resistance. Efficacy of cisplatin chemotherapy in the treatment of distinct malignancies is often hampered by intrinsic/ acquired drug resistance of tumors. EXPERIMENTAL DESIGN: We produced 14 orthoxenograft transplanting human nonseminomatous (NSE) testicular germ cell tumors (TGCTs) to mice, keeping the primary tumor features (genotype, phenotype and sensitivity to cisplatin). Chromosomal and genetic alterations were evaluated in matched cisplatin-sensitive and their counterpart orthoxenografts that developed resistance to cisplatin in vivo...
April 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29618105/physician-time-burden-associated-with-querying-prescription-drug-monitoring-programs
#11
Marcus A Bachhuber, Brendan Saloner, Marc LaRochelle, Jessica S Merlin, Brandon C Maughan, Dan Polsky, Naum Shaparin, Sean M Murphy
Objective: Prescription drug monitoring programs (PDMPs) enable prescribers to review patient prescription histories, and their use is mandatory in many states. We estimated the cost of physicians retrieving PDMP patient reports compared with a model where a delegate (i.e., administrative staff) retrieves reports. Methods: We performed a cost analysis with a one-year time horizon, from the perspective of physicians' employers. We obtained specialty-specific estimates of controlled substance prescribing frequency from the National Ambulatory Medical Care Survey, 2012-2014...
March 30, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29599017/opioid-prescribing-practices-from-2010-through-2015-among-dentists-in-the-united-states-what-do-claims-data-tell-us
#12
Niodita Gupta, Marko Vujicic, Andrew Blatz
BACKGROUND: Dentists wrote 6.4% of all opioid prescriptions in the United States in 2012. The purpose of this study was to examine opioid prescription rates, dosage of opioids prescribed, type of opioid drug prescribed, and type of dental visit at which dentists prescribe opioids. METHODS: The authors used the 2010 through 2015 Truven Health Marketscan Research databases and the Prescription Drug Monitoring Program (PDMP) Training and Technical Assistance Center conversion data set...
April 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29560070/optimal-implementation-of-prescription-drug-monitoring-programs-in-the-emergency-department
#13
REVIEW
Joshua W Elder, Garrett DePalma, Jesse M Pines
The opioid epidemic is the most significant modern-day, public health crisis. Physicians and lawmakers have developed methods and practices to curb opioid use. This article describes one method, prescription drug monitoring programs (PDMP), through the lens of how to optimize use for emergency departments (ED). EDs have rapidly become a central location to combat opioid abuse and drug diversion. PDMPs can provide emergency physicians with comprehensive prescribing information to improve clinical decisions around opioids...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29550022/opioid-prescribing-and-risk-mitigation-implementation-in-the-management-of-acute-pain-results-from-the-national-dental-practice-based-research-network
#14
Jenna L McCauley, Renata S Leite, Valeria V Gordan, Roger B Fillingim, Gregg H Gilbert, Cyril Meyerowitz, David Cochran, D Brad Rindal, Kathleen T Brady
BACKGROUND: Minimal information exists regarding the consistency and correlates of dentists' implementation of risk mitigation strategies when prescribing opioids, including risk screening, prescription drug monitoring program (PDMP) use, and patient education. METHODS: The authors conducted a Web-based, cross-sectional survey among practicing dentist members of The National Dental Practice-Based Research Network. The authors used the survey to assess pain management prescribing practices and risk mitigation implementation...
May 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29525483/an-opioid-dispensing-and-misuse-prevention-algorithm-for-community-pharmacy-practice
#15
Nathaniel M Rickles, Amy L Huang, Michelle B Gunther, Winney J Chan
BACKGROUND: Prescription opioid abuse has rapidly increased in recent years and is now considered a national epidemic by the United States government. Community pharmacies are at the forefront of opioid abuse, given their role in dispensing opioid prescriptions. Despite this role, however, there are few known guidelines to help community pharmacists navigate the process of detecting and managing prescription opioid abuse. OBJECTIVES: To develop and evaluate a candidate guideline, based on clinical experience and existing literature, to help community pharmacists monitor and manage potential opioid prescription abuse...
February 21, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29520747/physicians-perspectives-regarding-prescription-drug-monitoring-program-use-within-the-department-of-veterans-affairs-a-multi-state-qualitative-study
#16
Thomas R Radomski, Felicia R Bixler, Susan L Zickmund, KatieLynn M Roman, Carolyn T Thorpe, Jennifer A Hale, Florentina E Sileanu, Leslie R M Hausmann, Joshua M Thorpe, Katie J Suda, Kevin T Stroupe, Adam J Gordon, Chester B Good, Michael J Fine, Walid F Gellad
BACKGROUND: The Department of Veterans Affairs (VA) has implemented robust strategies to monitor prescription opioid dispensing, but these strategies have not accounted for opioids prescribed by non-VA providers. State-based prescription drug monitoring programs (PDMPs) are a potential tool to identify VA patients' receipt of opioids from non-VA prescribers, and recent legislation requires their use within VA. OBJECTIVE: To evaluate VA physicians' perspectives and experiences regarding use of PDMPs to monitor Veterans' receipt of opioids from non-VA prescribers...
March 8, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29490325/suboptimal-opioid-prescribing-a-practice-change-project
#17
Linda S Young, Robert S Crausman, John P Fulton
In the U.S. in 2015, the proportion of people dependent on opioids approached one percent, and opioid overdose rivaled auto accidents as the leading cause of accidental death. The literature suggests a credible link between increased opioid prescribing and increased opioid addiction. Accordingly, some have suggested that limiting the number of opioid prescriptions (and the number of doses per prescription) might be effective in reducing the number of opioid-related deaths. Toward this end, we designed and piloted an evidence-based quality-improvement project in four urgent care clinics...
March 1, 2018: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/29485950/estimating-the-direct-costs-of-outpatient-opioid-prescriptions-a-retrospective-analysis-of-data-from-the-rhode-island-prescription-drug-monitoring-program
#18
Hilary Aroke, Ashley Buchanan, Xuerong Wen, Peter Ragosta, Jennifer Koziol, Stephen Kogut
BACKGROUND: Overuse and misuse of prescription opioids is associated with increased morbidity and mortality and places a significant cost burden on health systems. OBJECTIVE: To estimate annual statewide spending for prescription opioids in Rhode Island. METHODS: A cross-sectional study of opioids dispensed from retail pharmacies using data from the Rhode Island Prescription Drug Monitoring Program (PDMP) was performed. The study sample consisted of 651,227 opioid prescriptions dispensed to 197,062 patients between January 1, 2015, and December 31, 2015...
March 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29482599/protocol-mixed-methods-study-to-evaluate-implementation-enforcement-and-outcomes-of-u-s-state-laws-intended-to-curb-high-risk-opioid-prescribing
#19
Emma E McGinty, Elizabeth A Stuart, G Caleb Alexander, Colleen L Barry, Mark C Bicket, Lainie Rutkow
BACKGROUND: The U.S. opioid epidemic has been driven by the high volume of opioids prescribed by healthcare providers. U.S. states have recently enacted four types of laws designed to curb high-risk prescribing practices, such as high-dose and long-term opioid prescribing, associated with opioid-related mortality: (1) mandatory Prescription Drug Monitoring Program (PDMP) enrollment laws, which require prescribers to enroll in their state's PDMP, an electronic database of patients' controlled substance prescriptions, (2) mandatory PDMP query laws, which require prescribers to query the PDMP prior to prescribing an opioid, (3) opioid prescribing cap laws, which limit the dose and/or duration of opioid prescriptions, and (4) pill mill laws, which strictly regulate pain clinics to prevent nonmedical opioid prescribing...
February 26, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29416613/efficient-inhibition-of-cervical-cancer-by-dual-drugs-loaded-in-biodegradable-thermosensitive-hydrogel-composites
#20
Shan Xu, Xiaobo Du, Gang Feng, Yu Zhang, Jie Li, Binwei Lin, Linglin Yang, Shaozhi Fu, Jingbo Wu
Background and Purpose: We aimed to explore the anti-tumor effect and mechanism of the combination of cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG, or PECE) and paclitaxel (PTX)-loaded MPEG-PCL polymeric micelles called PDMP on human cervical carcinoma (HeLa) cell. In our previous studies, we found that PDMP in situ treatment of lung cancer will be liable to have potential in Lung cancer patients. Results: Compared with other treatments, PDMP was most effective in prolonging survival time ( P < 0...
January 2, 2018: Oncotarget
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