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https://www.readbyqxmd.com/read/29677414/a-multistep-approach-to-address-clinican-knowledge-attitudes-and-behavior-around-opioid-prescribing
#1
Sara Kohlbeck, Brenna Akert, Caroline Pace, Amy Zosel
INTRODUCTION: The Wisconsin Prescription Drug Monitoring Program (PDMP) was implemented in 2013 to reduce the misuse, abuse, and diversion of controlled substance prescriptions. OBJECTIVE: To evaluate provider knowledge, attitudes, and behaviors regarding the Wisconsin PDMP before and after study interventions. METHODS: An initial survey of clinicians, a focus group, pre- and posttests for an educational session, and a 3-month follow-up survey were utilized...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29618620/orthoxenografts-of-testicular-germ-cell-tumors-demonstrate-genomic-changes-associated-with-cisplatin-resistance-and-identify-pdmp-as-a-re-sensitizing-agent
#2
Josep Maria Piulats, August Vidal, Francisco J García-Rodríguez, Clara Muñoz, Marga Nadal, Catia Moutinho, Maria Martínez-Iniesta, Josefina Mora, Agnes Figueras, Elisabet Guinó, Laura Padullés, Àlvaro Aytés, David G Mollevi, Sara Puertas, Carmen Martínez-Fernández, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificacion Muñoz, Milica Stefanovic, Miguel Angel Pujana, Enric Condom, Manel Esteller, Josep R Germà-LLuch, Gabriel Capella, Lourdes Farré, Albert Morales, Francesc Viñals, Xavier Garcia Del Muro, Julián Cerón, Alberto Villanueva
PURPOSE: To investigate the genetic basis of cisplatin resistance. Efficacy of cisplatin chemotherapy in the treatment of distinct malignancies is often hampered by intrinsic/ acquired drug resistance of tumors. EXPERIMENTAL DESIGN: We produced 14 orthoxenograft transplanting human nonseminomatous (NSE) testicular germ cell tumors (TGCTs) to mice, keeping the primary tumor features (genotype, phenotype and sensitivity to cisplatin). Chromosomal and genetic alterations were evaluated in matched cisplatin-sensitive and their counterpart orthoxenografts that developed resistance to cisplatin in vivo...
April 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29618105/physician-time-burden-associated-with-querying-prescription-drug-monitoring-programs
#3
Marcus A Bachhuber, Brendan Saloner, Marc LaRochelle, Jessica S Merlin, Brandon C Maughan, Dan Polsky, Naum Shaparin, Sean M Murphy
Objective: Prescription drug monitoring programs (PDMPs) enable prescribers to review patient prescription histories, and their use is mandatory in many states. We estimated the cost of physicians retrieving PDMP patient reports compared with a model where a delegate (i.e., administrative staff) retrieves reports. Methods: We performed a cost analysis with a one-year time horizon, from the perspective of physicians' employers. We obtained specialty-specific estimates of controlled substance prescribing frequency from the National Ambulatory Medical Care Survey, 2012-2014...
March 30, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29599017/opioid-prescribing-practices-from-2010-through-2015-among-dentists-in-the-united-states-what-do-claims-data-tell-us
#4
Niodita Gupta, Marko Vujicic, Andrew Blatz
BACKGROUND: Dentists wrote 6.4% of all opioid prescriptions in the United States in 2012. The purpose of this study was to examine opioid prescription rates, dosage of opioids prescribed, type of opioid drug prescribed, and type of dental visit at which dentists prescribe opioids. METHODS: The authors used the 2010 through 2015 Truven Health Marketscan Research databases and the Prescription Drug Monitoring Program (PDMP) Training and Technical Assistance Center conversion data set...
April 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29560070/optimal-implementation-of-prescription-drug-monitoring-programs-in-the-emergency-department
#5
REVIEW
Joshua W Elder, Garrett DePalma, Jesse M Pines
The opioid epidemic is the most significant modern-day, public health crisis. Physicians and lawmakers have developed methods and practices to curb opioid use. This article describes one method, prescription drug monitoring programs (PDMP), through the lens of how to optimize use for emergency departments (ED). EDs have rapidly become a central location to combat opioid abuse and drug diversion. PDMPs can provide emergency physicians with comprehensive prescribing information to improve clinical decisions around opioids...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29550022/opioid-prescribing-and-risk-mitigation-implementation-in-the-management-of-acute-pain-results-from-the-national-dental-practice-based-research-network
#6
Jenna L McCauley, Renata S Leite, Valeria V Gordan, Roger B Fillingim, Gregg H Gilbert, Cyril Meyerowitz, David Cochran, D Brad Rindal, Kathleen T Brady
BACKGROUND: Minimal information exists regarding the consistency and correlates of dentists' implementation of risk mitigation strategies when prescribing opioids, including risk screening, prescription drug monitoring program (PDMP) use, and patient education. METHODS: The authors conducted a Web-based, cross-sectional survey among practicing dentist members of The National Dental Practice-Based Research Network. The authors used the survey to assess pain management prescribing practices and risk mitigation implementation...
March 14, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29525483/an-opioid-dispensing-and-misuse-prevention-algorithm-for-community-pharmacy-practice
#7
Nathaniel M Rickles, Amy L Huang, Michelle B Gunther, Winney J Chan
BACKGROUND: Prescription opioid abuse has rapidly increased in recent years and is now considered a national epidemic by the United States government. Community pharmacies are at the forefront of opioid abuse, given their role in dispensing opioid prescriptions. Despite this role, however, there are few known guidelines to help community pharmacists navigate the process of detecting and managing prescription opioid abuse. OBJECTIVES: To develop and evaluate a candidate guideline, based on clinical experience and existing literature, to help community pharmacists monitor and manage potential opioid prescription abuse...
February 21, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29520747/physicians-perspectives-regarding-prescription-drug-monitoring-program-use-within-the-department-of-veterans-affairs-a-multi-state-qualitative-study
#8
Thomas R Radomski, Felicia R Bixler, Susan L Zickmund, KatieLynn M Roman, Carolyn T Thorpe, Jennifer A Hale, Florentina E Sileanu, Leslie R M Hausmann, Joshua M Thorpe, Katie J Suda, Kevin T Stroupe, Adam J Gordon, Chester B Good, Michael J Fine, Walid F Gellad
BACKGROUND: The Department of Veterans Affairs (VA) has implemented robust strategies to monitor prescription opioid dispensing, but these strategies have not accounted for opioids prescribed by non-VA providers. State-based prescription drug monitoring programs (PDMPs) are a potential tool to identify VA patients' receipt of opioids from non-VA prescribers, and recent legislation requires their use within VA. OBJECTIVE: To evaluate VA physicians' perspectives and experiences regarding use of PDMPs to monitor Veterans' receipt of opioids from non-VA prescribers...
March 8, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29490325/suboptimal-opioid-prescribing-a-practice-change-project
#9
Linda S Young, Robert S Crausman, John P Fulton
In the U.S. in 2015, the proportion of people dependent on opioids approached one percent, and opioid overdose rivaled auto accidents as the leading cause of accidental death. The literature suggests a credible link between increased opioid prescribing and increased opioid addiction. Accordingly, some have suggested that limiting the number of opioid prescriptions (and the number of doses per prescription) might be effective in reducing the number of opioid-related deaths. Toward this end, we designed and piloted an evidence-based quality-improvement project in four urgent care clinics...
March 1, 2018: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/29485950/estimating-the-direct-costs-of-outpatient-opioid-prescriptions-a-retrospective-analysis-of-data-from-the-rhode-island-prescription-drug-monitoring-program
#10
Hilary Aroke, Ashley Buchanan, Xuerong Wen, Peter Ragosta, Jennifer Koziol, Stephen Kogut
BACKGROUND: Overuse and misuse of prescription opioids is associated with increased morbidity and mortality and places a significant cost burden on health systems. OBJECTIVE: To estimate annual statewide spending for prescription opioids in Rhode Island. METHODS: A cross-sectional study of opioids dispensed from retail pharmacies using data from the Rhode Island Prescription Drug Monitoring Program (PDMP) was performed. The study sample consisted of 651,227 opioid prescriptions dispensed to 197,062 patients between January 1, 2015, and December 31, 2015...
March 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29482599/protocol-mixed-methods-study-to-evaluate-implementation-enforcement-and-outcomes-of-u-s-state-laws-intended-to-curb-high-risk-opioid-prescribing
#11
Emma E McGinty, Elizabeth A Stuart, G Caleb Alexander, Colleen L Barry, Mark C Bicket, Lainie Rutkow
BACKGROUND: The U.S. opioid epidemic has been driven by the high volume of opioids prescribed by healthcare providers. U.S. states have recently enacted four types of laws designed to curb high-risk prescribing practices, such as high-dose and long-term opioid prescribing, associated with opioid-related mortality: (1) mandatory Prescription Drug Monitoring Program (PDMP) enrollment laws, which require prescribers to enroll in their state's PDMP, an electronic database of patients' controlled substance prescriptions, (2) mandatory PDMP query laws, which require prescribers to query the PDMP prior to prescribing an opioid, (3) opioid prescribing cap laws, which limit the dose and/or duration of opioid prescriptions, and (4) pill mill laws, which strictly regulate pain clinics to prevent nonmedical opioid prescribing...
February 26, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29416613/efficient-inhibition-of-cervical-cancer-by-dual-drugs-loaded-in-biodegradable-thermosensitive-hydrogel-composites
#12
Shan Xu, Xiaobo Du, Gang Feng, Yu Zhang, Jie Li, Binwei Lin, Linglin Yang, Shaozhi Fu, Jingbo Wu
Background and Purpose: We aimed to explore the anti-tumor effect and mechanism of the combination of cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG, or PECE) and paclitaxel (PTX)-loaded MPEG-PCL polymeric micelles called PDMP on human cervical carcinoma (HeLa) cell. In our previous studies, we found that PDMP in situ treatment of lung cancer will be liable to have potential in Lung cancer patients. Results: Compared with other treatments, PDMP was most effective in prolonging survival time (P < 0...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29403323/evaluation-of-thrombosis-related-biomarkers-before-and-after-therapy-in-patients-with-multiple-myeloma
#13
Shosaku Nomura, Tomoki Ito, Hideaki Yoshimura, Masaaki Hotta, Takahisa Nakanishi, Shinya Fujita, Aya Nakaya, Atsushi Satake, Kazuyoshi Ishii
Background: Thrombosis is one of the complications in the clinical course of multiple myeloma (MM). Vascular endothelial cells and/or the hemostatic-coagulatory system are thought to play an important role in thrombosis of MM. In addition to melphalan-prednisone (Mel-P) therapy, several new therapeutic drugs such as lenalidomide or bortezomib have been developed and show effectiveness against MM. However, these new drugs also have risk of therapy-related thrombosis. Methods: We assessed 103 MM patients and 30 healthy controls, using enzyme-linked immunosorbent assays to evaluate five biomarkers: platelet-derived microparticles (PDMP), plasminogen activator inhibitor-1 (PAI-1), high mobility group box protein-1 (HMGB1), endothelial protein C receptor (EPCR), and soluble vascular cell adhesion molecule-1 (sVCAM-1)...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29402676/features-of-prescription-drug-monitoring-programs-associated-with-reduced-rates-of-prescription-opioid-related-poisonings
#14
N J Pauly, S Slavova, C Delcher, P R Freeman, J Talbert
BACKGROUND: The United States is in the midst of an opioid epidemic. In addition to other system-level interventions, all states have responded during the crisis by implementing prescription drug monitoring programs (PDMPs). This study examines associations between specific administrative features of PDMPs and changes in the risk of prescription opioid-related poisoning (RxORP) over time. METHODS: This longitudinal, observational study utilized a 'natural experiment' design to assess associations between PDMP features and risk of RxORP in a nationally-representative population of privately-insured adults from 2004 to 2014...
January 11, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29386401/efficient-analysis-of-stochastic-gene-dynamics-in-the-non-adiabatic-regime-using-piecewise-deterministic-markov-processes
#15
Yen Ting Lin, Nicolas E Buchler
Single-cell experiments show that gene expression is stochastic and bursty, a feature that can emerge from slow switching between promoter states with different activities. In addition to slow chromatin and/or DNA looping dynamics, one source of long-lived promoter states is the slow binding and unbinding kinetics of transcription factors to promoters, i.e. the non-adiabatic binding regime. Here, we introduce a simple analytical framework, known as a piecewise deterministic Markov process (PDMP), that accurately describes the stochastic dynamics of gene expression in the non-adiabatic regime...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29347984/the-effects-of-state-rules-on-opioid-prescribing-in-indiana
#16
Morhaf Al Achkar, Shaun Grannis, Debra Revere, Palmer MacKie, Meredith Howard, Sumedha Gupta
BACKGROUND: Prescription opioids have been linked to over half of the 28,000 opioid overdose deaths in 2014. High rates of prescription opioid non-medical use have continued despite nearly all states implementing large-scale prescription drug monitoring programs (PDMP), which points to the need to examine the impact of state PDMP's on curbing inappropriate opioid prescribing. In the short-term, PDMPs have been associated with short-term prescribing declines. Yet little is known about how such policies differentially impact patient subgroups or are interpreted by prescribing providers...
January 18, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29323819/the-use-of-a-statewide-prescription-drug-monitoring-program-by-emergency-department-physicians
#17
Jennifer L Hernandez-Meier, Rachel Muscott, Amy Zosel
BACKGROUND: Little is known about how emergency physicians have used Wisconsin's Prescription Drug Monitoring Program (PDMP). OBJECTIVE: To characterize emergency physician knowledge and utilization of the program and how it modifies practice. METHODS: Online survey data were collected 1 year after program implementation. Descriptive statistics were generated and qualitative responses were grouped by content. RESULTS: Of the 63 respondents, 64...
June 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29297725/prescription-drug-monitoring-programs-and-pharmacist-orientation-toward-dispensing-controlled-substances
#18
Michael Fendrich, Janelle K Bryan, Katinka Hooyer
OBJECTIVES: We sought to understand how pharmacists viewed and used a newly implemented prescription drug monitoring program (PDMP). We also sought to understand pharmacist orientation toward dispensing of controlled substances and the people who obtain them. METHODS: We conducted three mini focus groups. The focus group findings were used to inform the design of a structured survey. We emailed a survey to 160 pharmacists who were employed in one statewide community chain store; we obtained 48 survey responses...
January 3, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29241835/the-effect-of-a-statewide-mandatory-prescription-drug-monitoring-program-on-opioid-prescribing-by-emergency-medicine-providers-across-15-hospitals-in-a-single-health-system
#19
Brian Suffoletto, Michael Lynch, Charissa B Pacella, Donald M Yealy, Clifton W Callaway
Prescription drug monitoring programs (PDMPs) enable registered prescribers to obtain real-time information on patients' prescription history of controlled medications. We sought to describe the effect of a state-mandated PDMP on opioid prescribing by emergency medicine providers. We retrospectively analyzed electronic medical records of 122,732 adult patients discharged with an opioid prescription from 15 emergency departments in a single health system in Pennsylvania from July 2015 to March, 2017. We used an interrupted time series design to evaluate the percentage of patients discharged each month with an opioid prescription before and after state law-mandated PDMP use on August 25, 2016...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29199394/trends-in-florida-s-prescription-drug-monitoring-program-registration-and-utilization-implications-for-increasing-voluntary-use
#20
Chris Delcher, Yanning Wang, Henry W Young, Bruce A Goldberger, Siegfried Schmidt, Gary M Reisfield
OBJECTIVE: Effective use of state prescription drug monitoring programs (PDMPs) to track controlled substance prescribing and dispensing may help mitigate the current opioid crisis. Our objective was to examine trends in registration for and use of Florida's PDMP by physicians and pharmacists, from 2013 to 2016. We discuss implications for PDMP uptake and policy. DESIGN: Key measures, such as cumulative number of registrants per license type and monthly utilization intensity, are presented...
September 2017: Journal of Opioid Management
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