Shaimaa Maher, Daniel Gerber, Brian Balog, Lan Wang, Mei Kuang, Brett Hanzlicek, Tejasvini Malakalapalli, Cassandra Van Etten, Roger Khouri, Margot S Damaser
Urinary incontinence is a common complication following radical prostatectomy, as the surgery disturbs critical anatomical structures. This study explored how pudendal nerve (PN) injury affects urinary continence in male rats. In an acute study, leak point pressure (LPP) and external urethral sphincter electromyography (EMG) were performed on six male rats with an intact urethra, the urethra exposed (UE), the PN exposed (NE), and after PN transection (PNT). In a chronic study, LPP and EMG were tested in 67 rats 4 days, 3 weeks, or 6 weeks after sham PN injury, PN crush (PNC), or PNT...
March 28, 2024: Scientific Reports