Anna Beckmeyer-Borowko, Medea Imboden, Faisal I Rezwan, Matthias Wielscher, Andre F S Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C Sharp, Caroline Relton, Alexander J Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W Holloway, Nicole M Probst-Hensch
BACKGROUND: The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants. A family based study of predominantly smoking adults found methylation at two Cytosine-phosphate-Guanine sites (CpGs) in SERPINA1 gene to be associated with chronic obstructive pulmonary disease risk. The objective of this study was to confirm the association of lung function with SERPINA1 methylation in general population samples by testing a comprehensive set of CpGs in the SERPINA gene cluster...
August 22, 2018: Respiratory Research