NIHA

Apigenin is a natural polyphenolic compound widely distributed as a glycoside in fruits and vegetables. Apigenin belongs to BCS class II with low solubility, which leads to poor absorption and bioavailability. It is mostly absorbed from the small intestine and extensively metabolized through glucuronidation and sulfation processes. Apigenin is known for its antioxidant and anti-inflammatory properties. It is also used as a chemopreventive drug in the management of various cancers. Pharmacological effects of apigenin have a wide range, from neuroprotective to treating renal disorders...

PURPOSE: This study was done to find the hidden balance problem in individuals across age groups using perceptual measure (Dizziness Index of Impairment in Activities of Daily Living Scale questionnaire, DII-ADL) and vestibulospinal-cerebellar function tests (Sharpened Romberg test, Fukuda stepping test, Tandem gait test, and Finger-to-nose test). METHODS: A total of 150 individuals in three age groups, young adults (20-40 years), middle-aged adults (40-60 years), and older adults (> 60 years) were considered...

INTRODUCTION: Transdermal drug delivery is limited by the stratum corneum, inhibiting the therapeutic potential of the permeants. Microneedles (MNs) have opened new frontiers in transdermal drug delivery systems. These micro-sized needles offer painless and accentuated delivery of drugs even with high molecular weights. AREAS COVERED: The review embodies drug delivery strategies with MNs with a description of MN types and fabrication techniques using various materials...

Almost half of NHS doctors are junior doctors, while high proportions are women and/or Black, Asian, and Minority Ethnic (BAME) individuals. Discrimination against this population is associated with poorer career-related outcomes and unequal representation. We aimed to qualitatively explore junior doctors' experience of workplace racial and gender-based discrimination, and its impact on their psychological distress (PD). In this study, we carried out a secondary analysis of data from a UK-based parent study about junior doctors' working cultures and conditions...

Secondary datasets of 42 low organic loading Vertical flow constructed wetlands (LOLVFCWs) were assessed to optimize their area requirements for N and P (nutrients) removal. Significant variations in removal rate coefficients (k20 ) (0.002-0.464 m d-1 ) indicated scope for optimization. Data classification based on nitrogen loading rate, temperature and depth could reduce the relative standard deviations of the k20 values only in some cases. As an alternative method of deriving k20 values, the effluent concentrations of the targeted pollutants were predicted using two machine learning approaches, MLR and SVR...

Varying the depth of HFCW media causes differences in the redox status within the system, and hence the community structure and diversity of bacteria, affecting removal rates of different pollutants. The key functional microorganisms of CWs that remove contaminants belong to the phyla Proteobacteria, Bacteroidetes, Actinobacteria, and Firmicutes. Secondary data of 111 HFCWs (1232 datasets) were analyzed to deduce the relationship between volumetric removal rate coefficients (KBOD , KTN , KTKN , and KTP ) and depth...

In today's digital world, and in light of the growing pandemic, many yoga instructors opt to teach online. However, even after learning or being trained by the best sources available, such as videos, blogs, journals, or essays, there is no live tracking available to the user to see if he or she is holding poses appropriately, which can lead to body posture issues and health issues later in life. Existing technology can assist in this regard; however, beginner-level yoga practitioners have no means of knowing whether their position is good or poor without the instructor's help...

Selinexor (KPT-330) is a small molecule inhibitor of XPO1 (exportin 1, Chromosome Region Maintenance 1/CRM1), which mediates the transport of tumor suppressor proteins, oncogene mRNAs and other proteins involved in governing cell growth, from the cell nucleus to the cytoplasm. It is often overexpressed in many cancer types. Since eukaryotic translation initiator factor 4E (eIF4E) plays a critical role in cancer protein translation in multiple myeloma (MM), we evaluated the effectiveness of combined inhibition of protein translation and with a nuclear export inhibitor in MM...

Timor-Leste is a small nation of 1.3 million people which shares a land border with Indonesia and is 550 km from Darwin, Australia. It is one of the poorest nations in Asia. The National Health Laboratory (NHL) and its network of smaller laboratories in Timor-Leste had limited capacity to perform molecular diagnostic testing before the coronavirus disease 2019 (COVID-19) pandemic began. With the support of international development partners, the NHL rapidly expanded its molecular testing service. From March 2020 to February 2022, over 200,000 molecular tests were performed; COVID-19 testing sites were established in hospital and community health center laboratories and all 13 municipalities, and the number of scientists and technicians at the molecular diagnostic laboratory at the NHL increased from five to 28 between 2019 and 2022...

OBJECTIVE: To develop a Deep Learning (DL) Artificial Intelligence (AI) model for the instance segmentation and numbering of teeth on Orthopantomograms (OPGs). METHODS: Forty OPGs were manually annotated to lay down the ground truth for training two Convolutional Neural Networks (CNNs), U-net, and Faster RCNN. These algorithms were concurrently trained and validated on a dataset of 1,280 teeth (40 OPGs) each. The U-net algorithm was trained on OPGs specifically annotated with fluid margins to label all 32 teeth via instance segmentation allowing each tooth to be denoted as a separate entity from the surrounding structures...

INTRODUCTION: Nanobubble is an innovative ultrasound contrast agent that triggers the development of targeted imaging of HER2-positive breast cancer by combining with HER2 affibody and IR783. HPPH is a second-generation photosensitiser that is effective in treating tumours. Hence, the nanobubble-IR783-HPPH-affibody (NIHA) complex demonstrates considerable potential in the treatment of HER2-positive breast cancer. METHODS: We fabricated the NIHA complex via an advanced thin-film hydration method and detected its characteristics such as particle size, morphology, stability, and cytotoxicity...

Timor-Leste, a small, mountainous half-island nation which shares a land border with Indonesia and which is 550 km from Australia, has a population of 1.3 million and achieved independence for the second time in 2002. It is one of the poorest nations in Asia. In response to the global coronavirus disease 2019 (COVID-19) pandemic, the Timor-Leste Ministry of Health undertook surveillance and contact tracing activities on all notified COVID-19 cases. Between 1 January 2020 and 30 June 2022, there were 22,957 cases of COVID-19 notified which occurred in three waves, the first which was delayed until April 2021 (community transmission of B...

This study aimed to analyze the existing literature on how artificial intelligence is being used to support the identification of cephalometric landmarks. The systematic analysis of literature was carried out by performing an extensive search in PubMed/MEDLINE, Google Scholar, Cochrane, Scopus, and Science Direct databases. Articles published in the last ten years were selected after applying the inclusion and exclusion criteria. A total of 17 full-text articles were systematically appraised. The Cochrane Handbook for Systematic Reviews of Interventions (CHSRI) and Newcastle-Ottawa quality assessment scale (NOS) were adopted for quality analysis of the included studies...

BACKGROUND: The Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp) is a widely used measure of spiritual wellbeing. However, consensus on the best factor structure for this measure has not been reached. Both a 2-factor (Meaning/Peace, Faith) and a 3-factor (Meaning, Peace, Faith) structure are reported in the literature. In this study, we examined the factorial structure of the FACIT-Sp in a population of patients with severe and/or life-limiting medical illnesses...

Treatment of skin cancer demands targeted delivery without minimal systemic circulation for maximum therapeutic window. Dermal delivery with nano-formulation offers such advantages. Therefore, present study aims to formulate Lyotropic liquid crystalline nanoparticles (LLC NPs) loaded with Apigenin (API) for dermal delivery using quality by design (QbD) approach for effective permeation resulting in improved bioavailability. Apigenin loaded LLC NPs (API-LLC NPs) were formulated and optimized by applying risk assessment and design of experiments (Box-Behnken Design)...

Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder caused by impaired B-cell function and antibody production. It commonly presents with chronic sinopulmonary and gastrointestinal manifestations. It is also associated with transformation to acute myeloid leukemia. However, the association of CVID with myelodysplastic syndrome (MDS) is rare. This case report aims to present one such rare association in a 26-year-old patient presenting with severe thrombocytopenia. Bone marrow biopsy revealed hypercellular marrow with 80-90% cellularity along with an increase in CD34 blasts...

Attention is a complex cognitive process with innate resource management and information selection capabilities for maintaining a certain level of functional awareness in socio-cognitive service agents. The human-machine society depends on creating illusionary believable behaviors. These behaviors include processing sensory information based on contextual adaptation and focusing on specific aspects. The cognitive processes based on selective attention help the agent to efficiently utilize its computational resources by scheduling its intellectual tasks, which are not limited to decision-making, goal planning, action selection, and execution of actions...

Present study aims to investigate how is soil affected following irrigation with treated effluents of different origins by analysing the bacterial diversity, metabolic diversity and antibiotic resistance genes (ARGs). Comparative analysis with previously reported ARGs in effluents was performed to understand the mobility of ARGs from treated wastewater to the irrigated soil with respect to the control soil regimen. Acinetobacter, Burkholderia and Pseudomonas were observed as the most abundant genera in all the samples...

Though chlorine is a cost-effective disinfectant for water and wastewaters, the bacteria surviving after chlorination pose serious public health and environmental problems. This review critically assesses the mechanism of chlorine disinfection as described by various researchers; factors affecting chlorination efficacy; and the re-growth potential of microbial contaminations in treated wastewater post chlorination to arrive at meaningful doses for ensuring health safety. Literature analysis shows procedural inconsistencies in the assessment of chlorine tolerant bacteria, making it extremely difficult to compare the tolerance characteristics of different reported tolerant bacteria...

PURPOSE: Dry eye disease (DED) is a common age-related ocular surface disease. However, it is unknown how aging influences the ocular surface microenvironment. This systematic review aims to investigate how the aging process changes the ocular surface microenvironment and impacts the development of DED. METHODS: An article search was performed in PubMed, EMBASE, and Web of Science. 44 studies reporting on age-related ocular changes and 14 large epidemiological studies involving the prevalence of DED were identified...