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https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#1
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29454168/genetic-and-environmental-influences-on-pubertal-hormones-in-human-hair-across-development
#2
Andrew D Grotzinger, Daniel A Briley, Laura E Engelhardt, Frank D Mann, Megan W Patterson, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
Puberty is a complex biopsychosocial process that can affect an array of psychiatric and medical disorders emerging in adolescence. Although the pubertal process is driven by neuroendocrine changes, few quantitative genetic studies have directly measured puberty-relevant hormones. Hair samples can now be assayed for accumulation of hormones over several months. In contrast to more conventional salivary measures, hair measures are not confounded by diurnal variation or hormonal reactivity. In an ethnically and socioeconomically diverse sample of 1286 child and adolescent twins and multiples from 672 unique families, we estimated genetic and environmental influences on hair concentrations of testosterone, DHEA, and progesterone across the period of 8-18 years of age...
April 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29338844/sfe-sfedp-adrenal-insufficiency-french-consensus-introduction-and-handbook
#3
Yves Reznik, Pascal Barat, Jérôme Bertherat, Claire Bouvattier, Frédéric Castinetti, Olivier Chabre, Philippe Chanson, Christine Cortet, Brigitte Delemer, Bernard Goichot, Damien Gruson, Laurence Guignat, Emmanuelle Proust-Lemoine, Marie-Laure Raffin Sanson, Rachel Reynaud, Dinane Samara Boustani, Dominique Simon, Antoine Tabarin, Delphine Zenaty
The French endocrinology society (SFE) and the French pediatric endocrinology society (DFSDP) have drawn up recommendations for the management of primary and secondary adrenal insufficiency in the adult and child, based on an analysis of the literature by 19 experts in 6 work-groups. A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms except hyperpigmentation which is observed in primary adrenal insufficiency. Diagnosis rely on plasma cortisol and ACTH measurement at 8am and/or the cortisol increase after synacthen administration...
February 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29323690/premature-adrenarche
#4
Laura Novello, Phyllis W Speiser
Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs of pubarche by conversion to more potent androgens, testosterone, and dihydrotestosterone. DHEA's extra-adrenal sulfation product, dehydroepiandrosterone sulfate, is a stable marker for adrenal androgenic activity. Pubarche is the physical manifestation of androgenic hormone production, and includes the development of pubic and axillary hair, adult body odor, and acne...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29171317/basal-blood-dhea-s-cortisol-levels-predicts-emdr-treatment-response-in-adolescents-with-ptsd
#5
Mirac Baris Usta, Yusuf Yasin Gumus, Gokce Nur Say, Abdullah Bozkurt, Berkan Şahin, Koray Karabekiroğlu
OBJECTIVE: In literature, recent evidence has shown that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in patients with post-traumatic stress disorder (PTSD) and HPA axis hormones may predict the psychotherapy treatment response in patients with PTSD. In this study, it was aimed to investigate changing cortisol and DHEA-S levels post-eye movement desensitization and reprocessing (EMDR) therapy and the relationship between treatment response and basal cortisol, and DHEA-S levels before treatment...
April 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28948822/changes-to-fetal-steroidogenesis-caused-by-maternal-smoking
#6
K Adamcová, L Kolátorová, T Chlupáčová, M Šimková, H Jandíková, A Pařízek, L Stárka, M Dušková
Smoking during pregnancy presents health risks for both the mother and her child. In this study we followed changes in the production of steroid hormones in pregnant smokers. We focused on changes in steroidogenesis in the blood of mothers in their 37(th) week of pregnancy and in mixed cord blood from their newborns. The study included 88 healthy women with physiological pregnancies (17 active smokers and 71 non-smokers). We separately analyzed hormonal changes associated with smoking according to the sex of newborns...
September 26, 2017: Physiological Research
https://www.readbyqxmd.com/read/28686893/a-relationship-in-adrenal-androgen-levels-between-mothers-and-their-children-from-a-dioxin-exposed-region-in-vietnam
#7
Le Thai Anh, Teruhiko Kido, Seijiro Honma, Ho Dung Manh, Ikue Koike, Yuko Oyama, Hoang Duc Phuc, Rie Okamoto, Hideaki Nakagawa, Shoji F Nakayama, Dang Duc Nhu, Nguyen Hung Minh, Ngo Van Toan, Le Ke Son
Over the past decades, southern Vietnam has been burdened by dioxins from contaminated herbicides sprayed during the Vietnam War. In a previous study, we found that dioxin exposure decreased levels of salivary dehydroepiandrosterone (DHEA), an adrenal androgen, in 3-year-old children. In present study, to assess the relationship between adrenal hormones disruption in lactating mothers and in children, we compared mother-child pairs from dioxin- and nondioxin-contaminated regions. In 2010 and 2011, mother-child pairs from a dioxin hotspot region (n=37) and a non-contaminated region (n=47) were recruited and donated breast milk and serum samples for dioxin and steroid hormones determination...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28587668/alterations-of-hair-cortisol-and-dehydroepiandrosterone-in-mother-infant-dyads-with-maternal-childhood-maltreatment
#8
K Schury, A M Koenig, D Isele, A L Hulbert, S Krause, M Umlauft, S Kolassa, U Ziegenhain, A Karabatsiakis, F Reister, H Guendel, J M Fegert, I-T Kolassa
BACKGROUND: Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition...
June 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28584276/persistent-lhpa-activation-in-german-individuals-raised-in-an-overprotective-parental-behavior
#9
E Ullmann, J Licinio, A Barthel, K Petrowski, T Stalder, S R Bornstein, C Kirschbaum
Parental upbringing may affect their offspring's mental state across the entire lifespan. Overprotective parental child-rearing style may increase the disease burden in the offspring. Furthermore, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-related disorders (TSRD) across generations. Studies with animals have demonstrated that the mother's immediate and expansive protection of the newborn decreases the limbic-hypothalamic-pituitary-adrenal (LHPA) axis activity in the offspring...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071011/the-effects-of-a-low-calorie-diet-or-an-isocaloric-diet-combined-with-metformin-on-sex-hormones-in-obese-women-of-child-bearing-age
#10
RANDOMIZED CONTROLLED TRIAL
Ewelina Swora-Cwynar, Magdalena Kujawska-Łuczak, Joanna Suliburska, Julita Reguła, Angelika Kargulewicz, Matylda Kręgielska-Narożna, Emilia Marcinkowska, Alina Kanikowska, Marzena Bielas, Marian Grzymisławski, Paweł Bogdański
BACKGROUND: The influence of weight loss treatment on sex hormones profile has been studied mainly in women with polycystic ovary syndrome (PCOS), but in obese premenopausal women without PCOS it still remains unclear. The aim of the study was to evaluate the effect of two approaches to obesity treatment on the serum level of sex hormones in obese women of child-bearing age without PCOS. METHODS: 77 obese Caucasian women (aged 31.2 ±8.3 years) were randomized into two groups: 39 women received a low-calorie diet (LC) and 38 received an isocaloric diet plus metformin (IM), for 12 weeks...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/27343975/effects-of-adrenal-androgens-during-the-prenatal-period-on-the-second-to-fourth-digit-ratio-in-school-aged-children
#11
Takahiko Mitsui, Atsuko Araki, Houman Goudarzi, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Nobuo Shinohara, Masayuki Takeda, Katsuya Nonomura
OBJECTIVES: We investigated the relationship between the levels of adrenal steroid hormones in cord blood and the second to fourth digit ratio (2D/4D), which is regarded as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. MATERIALS AND METHODS: Of the 514 mother-child pairs who participated in the prospective cohort study of birth in Sapporo between 2002 and 2005, the following adrenal steroid hormone levels in 294 stored cord blood samples (135 males and 159 females) were measured; cortisol, cortisone, androstenedione and dehydroepiandrosterone (DHEA)...
September 2016: Steroids
https://www.readbyqxmd.com/read/26820928/inverse-association-of-highly-chlorinated-dioxin-congeners-in-maternal-breast-milk-with-dehydroepiandrosterone-levels-in-three-year-old-vietnamese-children
#12
Teruhiko Kido, Seijiro Honma, Dang Duc Nhu, Ho Dung Manh, Dao Van Tung, Sun Xian Liang, Le Thai Anh, Rie Okamoto, Shoko Maruzeni, Hideaki Nakagawa, Nguyen Ngoc Hung, Le Ke Son
This study aims to evaluate the endocrine-disrupting effect of dioxin congeners on adrenal steroid hormones in mother-child pairs. In our previous study, we found that cortisol and cortisone levels were higher in the blood and the saliva of mothers living in a dioxin hotspot area than in mothers from a non-exposed region in Vietnam. In this follow-up study, we determined the salivary steroid hormone levels in 49 and 55 three-year-old children of these mothers in the hotspot and non-exposed region, respectively...
April 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26174795/decreased-dehydroepiandrosterone-sulphate-levels-in-adolescents-with-post-traumatic-stress-disorder-after-single-sexual-trauma
#13
Mirac Baris Usta, Ozgur Korhan Tuncel, Seher Akbas, Berna Aydin, Gokce Nur Say
BACKGROUND: Recent evidence shows that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in chronic sexual abuse victims with post-traumatic stress disorder (PTSD). We hypothesized that PTSD in adolescents exposed to a single sexual trauma may function as a chronic stressor leading to HPA-axis dysregulation. AIMS: The objective of this study was to assess dehydroepiandrosterone sulphate (DHEA-S) and cortisol levels in female adolescents |with single sexual trauma-related PTSD compared to healthy controls...
2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/25462892/tactics-for-modeling-multiple-salivary-analyte-data-in-relation-to-behavior-problems-additive-ratio-and-interaction-effects
#14
Frances R Chen, Adrian Raine, Douglas A Granger
Individual differences in the psychobiology of the stress response have been linked to behavior problems in youth yet most research has focused on single signaling molecules released by either the hypothalamic-pituitary-adrenal axis or the autonomic nervous system. As our understanding about biobehavioral relationships develops it is clear that multiple signals from the biological stress systems work in coordination to affect behavior problems. Questions are raised as to whether coordinated effects should be statistically represented as ratio or interactive terms...
January 2015: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/25450675/identification-of-cyp3a7-for-glyburide-metabolism-in-human-fetal-livers
#15
Diana L Shuster, Linda J Risler, Bhagwat Prasad, Justina C Calamia, Jenna L Voellinger, Edward J Kelly, Jashvant D Unadkat, Mary F Hebert, Danny D Shen, Kenneth E Thummel, Qingcheng Mao
Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have short- and long-term consequences for the health of the child. Glyburide can cross the placenta; fetal concentrations at term are nearly comparable to maternal levels. Whether or not glyburide is metabolized in the fetus and by what mechanisms has yet to be determined. In this study, we determined the kinetic parameters for glyburide depletion by CYP3A isoenzymes; characterized glyburide metabolism by human fetal liver tissues collected during the first or early second trimester of pregnancy; and identified the major enzyme responsible for glyburide metabolism in human fetal livers...
December 15, 2014: Biochemical Pharmacology
https://www.readbyqxmd.com/read/25336708/evidence-for-gonadotrophin-secretory-and-steroidogenic-abnormalities-in-brothers-of-women-with-polycystic-ovary-syndrome
#16
D M Liu, L C Torchen, Y Sung, R Paparodis, R S Legro, S K Grebe, R J Singh, R L Taylor, A Dunaif
STUDY QUESTION: Are there abnormalities in gonadotrophin secretion, adrenal steroidogenesis and/or testicular steroidogenesis in brothers of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Brothers of women with PCOS have increased gonadotrophin responses to gonadotrophin releasing hormone (GnRH) agonist stimulation and alterations in adrenal and gonadal steroidogenesis. WHAT IS KNOWN ALREADY: PCOS is a complex genetic disease...
December 2014: Human Reproduction
https://www.readbyqxmd.com/read/25213098/coupling-of-the-hpa-and-hpg-axes-in-the-context-of-early-life-adversity-in-incarcerated-male-adolescents
#17
Andrew R Dismukes, Megan M Johnson, Michael J Vitacco, Florencia Iturri, Elizabeth A Shirtcliff
The effects of early life adversity can be observed across the lifespan, and the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes could be mechanistic intermediaries underlying this phenomenon. The current study examined 50 adolescent males aged 12-18 in a maximum-security correctional and treatment setting. Saliva samples were collected five times a day for 2 days and assayed for cortisol, testosterone, and DHEA. Youth completed semi-structured life stress interviews and self-reports of child maltreatment to index adversity...
September 2015: Developmental Psychobiology
https://www.readbyqxmd.com/read/25173057/in-utero-and-peripubertal-exposure-to-phthalates-and-bpa-in-relation-to-female-sexual-maturation
#18
Deborah J Watkins, Martha Maria Téllez-Rojo, Kelly K Ferguson, Joyce M Lee, Maritsa Solano-Gonzalez, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
The age of pubertal onset for girls has declined over past decades. Research suggests that endocrine disrupting chemicals (EDCs) may play a role but exposure at multiple stages of development has not been considered. We examined in utero and peripubertal exposure to bisphenol-A (BPA) and phthalates in relation to serum hormones and sexual maturation among females in a Mexico City birth cohort. We measured phthalate metabolite and BPA concentrations in urine collected from mothers during their third trimester (n=116) and from their female children at ages 8-13 years (n=129)...
October 2014: Environmental Research
https://www.readbyqxmd.com/read/25140921/maternal-distress-in-early-life-predicts-the-waist-to-hip-ratio-in-schoolchildren
#19
A L Kozyrskyj, Y Zeng, I Colman, K T HayGlass, E A C Sellers, A B Becker, B J MacNeil
We report on life course stress determinants of overweight in children, using data from the longitudinal follow-up of the nested case-control arm of the SAGE (study of asthma genes and the environment) birth cohort in Manitoba, Canada. Waist and hip measurements were obtained during a clinic visit at age 9-11 years. Multiple linear regression was conducted to determine the relationship between the waist-to-hip ratio and maternal smoking during pregnancy, postpartum maternal distress and stress reactivity in children (cortisol, cortisol-DHEA [dihydroepiandrostrenone] ratio quartiles) following a clinic stressor at age 8-10 years...
April 2011: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/25029416/hormone-changes-in-peripubertal-girls
#20
COMPARATIVE STUDY
Frank M Biro, Susan M Pinney, Bin Huang, Erin R Baker, Donald Walt Chandler, Lorah D Dorn
CONTEXT: Studies of hormone changes in the peripubertal period note increases in adrenal hormones prior to increases in sex steroids. It is unclear how these processes are related to each other, except through this temporal relationship. OBJECTIVE: Examine relationships in adrenal and sex hormones in 252 peripubertal girls. SETTING AND DESIGN: Longitudinal observation study. School districts, at the Cincinnati site of the Breast Cancer and the Environment Research Centers, between 2004-2010...
October 2014: Journal of Clinical Endocrinology and Metabolism
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